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by duncan
Sun 4 Dec 2016 21:47
Forum: Published Studies
Topic: Ceftriaxone Pulse Dosing Fails to Eradicate Biofilm-Like Bb Persisters
Replies: 118
Views: 29086

Re: Ceftriaxone Pulse Dosing Fails to Eradicate Biofilm-Like Bb Persisters

The ethical principal at stake here is denying patients, who are not cured by a controversial treatment regimen, of future treatments even if they have evidence of infection. You cannot say, "Hey, to get diagnosed, you must meet these requirements", then discard those requirements AFTER a treatment ...
by duncan
Sun 4 Dec 2016 19:00
Forum: Published Studies
Topic: Ceftriaxone Pulse Dosing Fails to Eradicate Biofilm-Like Bb Persisters
Replies: 118
Views: 29086

Re: Ceftriaxone Pulse Dosing Fails to Eradicate Biofilm-Like Bb Persisters

Henry, where does it say that someone needs direct evidence to be diagnosed with early Lyme (is even an EM required here?), early disseminated, or late stage? What do the IDSA Guidelines suggest? Have you seen what they generally have to say relative to PCR testing? And no, I have not tried "the Sap...
by duncan
Sun 4 Dec 2016 17:43
Forum: Published Studies
Topic: Ceftriaxone Pulse Dosing Fails to Eradicate Biofilm-Like Bb Persisters
Replies: 118
Views: 29086

Re: Ceftriaxone Pulse Dosing Fails to Eradicate Biofilm-Like Bb Persisters

Would the NIH make any monies off those patents, theoretically?
by duncan
Sun 4 Dec 2016 17:23
Forum: Published Studies
Topic: Ceftriaxone Pulse Dosing Fails to Eradicate Biofilm-Like Bb Persisters
Replies: 118
Views: 29086

Re: Ceftriaxone Pulse Dosing Fails to Eradicate Biofilm-Like Bb Persisters

Sorry, Henry, we were posting/editing at about the same time. I had asked Henry how large the TBD diagnostic market was, but then decided it was irrelevent. Thank you for the explanation. Let me ask you this, while we are on this subject: What happens if a govt agency like the NIH is involved in the...
by duncan
Sun 4 Dec 2016 15:41
Forum: Published Studies
Topic: Ceftriaxone Pulse Dosing Fails to Eradicate Biofilm-Like Bb Persisters
Replies: 118
Views: 29086

Re: Ceftriaxone Pulse Dosing Fails to Eradicate Biofilm-Like Bb Persisters

Wow. You really are cozy with that nifty little handbook, aren't you, Henry? :) I'm not buying what you're selling. And that handbook needs updating. Henry, somewhere in the IDSA Guidelines there is a line - and I am paraphrasing from memory here, so excuse me if I'm off a bit - that basically says ...
by duncan
Sat 3 Dec 2016 22:17
Forum: Published Studies
Topic: Ceftriaxone Pulse Dosing Fails to Eradicate Biofilm-Like Bb Persisters
Replies: 118
Views: 29086

Re: Ceftriaxone Pulse Dosing Fails to Eradicate Biofilm-Like Bb Persisters

Bull. You are describing Steere's disease. As for the studies, you need to be looking at more variables than just the abx - duration of treatment, for example. I suspect in the US the principal manifestations of late stage Borreliosis are neurological. I am talking real-world here, Henry. Not some m...
by duncan
Sat 3 Dec 2016 21:30
Forum: Published Studies
Topic: Ceftriaxone Pulse Dosing Fails to Eradicate Biofilm-Like Bb Persisters
Replies: 118
Views: 29086

Re: Ceftriaxone Pulse Dosing Fails to Eradicate Biofilm-Like Bb Persisters

Apples and oranges, Henry. I'm not talking about some manufactured syndrome. I'm talking late stage Lyme. I also am familiar with those studies, and imo they have so many holes in them they'd sink if ever forced to float on their own merits.
by duncan
Sat 3 Dec 2016 20:20
Forum: Published Studies
Topic: Ceftriaxone Pulse Dosing Fails to Eradicate Biofilm-Like Bb Persisters
Replies: 118
Views: 29086

Re: Ceftriaxone Pulse Dosing Fails to Eradicate Biofilm-Like Bb Persisters

Which cannot be done. Forget about culturing. PCR is a joke - indeed even the IDSA notes its low yield. So, how do you go about proving abx therapy has failed? It's devilishly difficult to do with the outrageously high bar organizations like the IDSA have set even just to get acknowledged with Lyme ...
by duncan
Sat 3 Dec 2016 17:42
Forum: Published Studies
Topic: Ceftriaxone Pulse Dosing Fails to Eradicate Biofilm-Like Bb Persisters
Replies: 118
Views: 29086

Re: Ceftriaxone Pulse Dosing Fails to Eradicate Biofilm-Like Bb Persisters

This discussion is not about me, but I will indulge you, Henry, but I hope not at the expense of this thread. I am currently: ELISA positive; WB IgG positive in accordance with CDC requirements, ie, five or more of their stipulated bands; and C6 positive. I was also at one time documented IgM positi...
by duncan
Sat 3 Dec 2016 0:21
Forum: Published Studies
Topic: Ceftriaxone Pulse Dosing Fails to Eradicate Biofilm-Like Bb Persisters
Replies: 118
Views: 29086

Re: Ceftriaxone Pulse Dosing Fails to Eradicate Biofilm-Like Bb Persisters

I have tried to explain. It's not important. I test positive for the ELISA. I have always tested positive for the ELISA. I test positive for the WB. Now try to focus back on the thread, which demonstrates once again that traditional abx are not a sure thing when it comes to treatment success - which...