From that great medical reference site, Wikipedia. http://en.wikipedia.org/wiki/Cytokine_storm
Hey, it's easy to understand. LOL
From Wikipedia, the free encyclopedia
A cytokine storm is a potentially fatal immune reaction consisting of a positive feedback loop between cytokines and immune cells, with highly elevated levels of various cytokines.
The primary symptoms of a cytokine storm are a high fever, swelling and redness, extreme fatigue, and nausea.
When the immune system is fighting pathogens, cytokines signal immune cells such as T-cells and macrophages to travel to the site of infection. In addition, cytokines activate those cells, stimulating them to produce more cytokines. Normally this feedback loop is kept in check by the body. However, in some instances, the reaction becomes uncontrolled, and too many immune cells are activated in a single place. The precise reason for this is not entirely understood, but may be caused by an exaggerated response when the immune system encounters a new and highly pathogenic invader. Cytokine storms have potential to do significant damage to body tissues and organs. If a cytokine storm occurs in the lungs, for example, fluids and immune cells such as macrophages may accumulate and eventually block off the airways, potentially resulting in death.
The cytokine storm (hypercytokinemia) is the systemic expression of a healthy and vigorous immune system resulting in the release of more than 150 inflammatory mediators (cytokines, oxygen free radicals, and coagulation factors). Both pro-inflammatory cytokines (such as Tumor necrosis factor-alpha, Interleukin-1, and Interleukin-6) and anti-inflammatory cytokines (such as interleukin 10, and interleukin 1 receptor antagonist) are elevated in the serum of patients experiencing a cytokine storm.
Cytokine storms can occur in a number of infectious and non-infectious diseases including graft versus host disease (GVHD), adult respiratory distress syndrome (ARDS), sepsis, avian influenza, smallpox, and systemic inflammatory response syndrome (SIRS).
The first reference to the term "cytokine storm" in the published medical literature appears to be by Ferrara et al in GVHD, in February 1993.
Then another person's take (not mine, but it's interesting)
I'll ignore the references to the Marshall Protocol and Benicar as not pertinent to this forum.
A new medical term, immunopathology, is being used to replace Jarisch-Herxheimer among the scientific community. Immunopathology refers to a branch of medicine that deals with the study of how the body fights off disease and the study of immunodeficiency diseases. Although the Herxheimer reaction and immunopathology have similar meanings, there is an important difference. Therefore, in order to be taken seriously by researchers who appreciate the difference, we must discard the use of Herxheimer as too vague and begin to use 'immunopathology' because its meaning is more accurate and acceptable.
According to wikipedia, "immunopathology refers to diseases of or caused by the immune system, such as autoimmune (hypersensitivity) diseases such as type I diabetes, allergies. In this sense 'immunopathogenic' diseases are those which infect the immune system such as HIV, and leukemias.
Immunopathology is used to denote malaise (disease) caused by the immune system during normal function. As the intraphagocytic bacteria are killed, the cells they lived in also die (apoptosis), and as the immune system tries to clear them up, patients experience malaise. Malaise comes not just from the 'cytokine storm', but also from the changes in CBC (Complete Blood Count). This explains the malaise we see as Benicar starts to kick in and activate the VDR and the reaction to the MP antibiotics, both direct and indirect from bacteria which have been killed.
The term immunopathology provides a far more detailed description of what is happening in, and during recovery from, chronic Th1 inflammatory diseases than the Herxheimer response which does not describe the collateral effects on the body and is commonly thought to occur only during acute bacterial illnesses.
Immunopathology means all the pathological changes, hormonal, endocrine, cell death and CBC changes, which occur as the immune system is doing its job and this is a critical distinction.
Jarisch-Herxheimer is correctly used only when describing an acute immunopathologic reaction such as was first seen in syphilis and is often noted with the initial treatment of acute Lyme disease. If doctors are familiar with the Herx reaction, it is in the context of treatment of an acute infection.
The Herxheimer reaction does not describe all the immunopathologic changes seen with continued effective treatment of chronic inflammation due to intracellular bacteria.
It is important for patients to differentiate between symptoms due to the initial profound hormonal changes when the Benicar blockade is put in place, symptoms provoked by stimulation due to sun exposure and symptoms due to bacterial kill because awareness leads to better management of symptoms during treatment.
Hormonal, endocrine, cell death and CBC changes, manifested in symptoms, will take place as long as CWD bacteria are being killed. Scientists understand these effects of the immune system reaction as immunopathology, a term which encompasses the total phenomenon of this continued response to long-term treatment.