Conspicuous impacts of inconspicuous hosts on LD. epidemic

General or non-medical topics with information and discussion related to Lyme disease and other tick-borne diseases.
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Yvonne
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Conspicuous impacts of inconspicuous hosts on LD. epidemic

Post by Yvonne » Sun 24 Feb 2008 11:52

1: Proc Biol Sci. 2008 Jan 22;275(1631):227-35. Links

Conspicuous impacts of inconspicuous hosts on the Lyme disease epidemic.

Brisson D, Dykhuizen DE, Ostfeld RS.
Department of Biology, University of Pennsylvania, Leidy Laboratories, 326, 433 South University Avenue, Philadelphia, PA 19104-6018, USA.

Emerging zoonotic pathogens are a constant threat to human health throughout the world. Control strategies to protect public health regularly fail, due in part to the tendency to focus on a single host species assumed to be the primary reservoir for a pathogen. Here, we present evidence that a diverse set of species can play an important role in determining disease risk to humans using Lyme disease as a model. Host-targeted public health strategies to control the Lyme disease epidemic in North America have focused on interrupting Borrelia burgdorferi sensu stricto (ss) transmission between blacklegged ticks and the putative dominant reservoir species, white-footed mice. However, B. burgdorferi ss infects more than a dozen vertebrate species, any of which could transmit the pathogen to feeding ticks and increase the density of infected ticks and Lyme disease risk. Using genetic and ecological data, we demonstrate that mice are neither the primary host for ticks nor the primary reservoir for B. burgdorferi ss, feeding 10% of all ticks and 25% of B. burgdorferi-infected ticks. Inconspicuous shrews feed 35% of all ticks and 55% of infected ticks. Because several important host species influence Lyme disease risk, interventions directed at a multiple host species will be required to control this epidemic.

PMID: 18029304 [PubMed - in process]


http://journals.royalsociety.org/conten ... 1568p10h6/
Listen to all,
plucking a feather from every passing goose,
but follow no one absolutely

cave76
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Joined: Sun 12 Aug 2007 2:27

Re: Conspicuous impacts of inconspicuous hosts on LD. epidemic

Post by cave76 » Sun 24 Feb 2008 16:15

I'm breaking up this abstract in case others have the same problem as I do with dense copy. :) And adding emphasis. It's has too many important points to make to take a chance it isn't read.

Thanks Yvonne!

Emerging zoonotic pathogens are a constant threat to human health throughout the world.

Control strategies to protect public health regularly fail, due in part to the tendency to focus on a single host species assumed to be the primary reservoir for a pathogen.

Here, we present evidence that a diverse set of species can play an important role in determining disease risk to humans using Lyme disease as a model.

Host-targeted public health strategies to control the Lyme disease epidemic in North America have focused on interrupting Borrelia burgdorferi sensu stricto (ss) transmission between blacklegged ticks and the putative dominant reservoir species, white-footed mice.

However, B. burgdorferi ss infects more than a dozen vertebrate species, any of which could transmit the pathogen to feeding ticks and increase the density of infected ticks and Lyme disease risk.

Using genetic and ecological data, we demonstrate that mice are neither the primary host for ticks nor the primary reservoir for B. burgdorferi ss, feeding 10% of all ticks and 25% of B. burgdorferi-infected ticks.

Inconspicuous shrews feed 35% of all ticks and 55% of infected ticks.

Because several important host species influence Lyme disease risk, interventions directed at a multiple host species will be required to control this epidemic.

PMID: 18029304 [PubMed - in process]

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Yvonne
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Re: Conspicuous impacts of inconspicuous hosts on LD. epidemic

Post by Yvonne » Sun 2 Mar 2008 12:05

Listen to all,
plucking a feather from every passing goose,
but follow no one absolutely

cave76
Posts: 3182
Joined: Sun 12 Aug 2007 2:27

Re: Conspicuous impacts of inconspicuous hosts on LD. epidemic

Post by cave76 » Sun 2 Mar 2008 16:11

Very interesting, Yvonne. It will take me a bit to wade through it all. Thanks for posting it.

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