Lyme Disease News & Current Medical Research

The latest publications of scientific medical research, articles and news on Lyme disease from many resources are automatically displayed here.

List of latest Lyme news and medical research

Friday 2 December 2016

Gold Coast Lyme disease sufferer writhes in pain in confronting video

At the age of 19, Rachel Battersby (pictured) from the Gold Coast was a  bright, fun-loving and healthy young woman, but today the girl who had the world at her feet now has her life in tatters. (Source: the Mail online | Health)

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Thursday 1 December 2016

Use of a tick-borne disease manual increases accuracy of tick identification among primary care providers in Lyme disease endemic areas

Publication date: Available online 23 November 2016 Source:Ticks and Tick-borne Diseases Author(s): Amber D. Butler, Meredith L. Carlson, Christina A. Nelson Given the high incidence of tick bites and tick-borne diseases in the United States, it is important for primary care providers to recognize common ticks and the pathogens they may transmit. If a patient has removed and saved an attached tick, identifying the tick helps guide clinical management and determine whether antibiotic prophylaxis for Lyme disease is appropriate. To investigate providers’ ability to recognize common ticks and the pathogens they may transmit, we asked 76 primary care providers from Lyme disease endemic areas to identify the common name or genus of preserved ticks found in their area. At baseline, 10.5%, 46....

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Wednesday 30 November 2016

Incidence and antibiotic treatment of erythema migrans in Norway 2005 –2009

Publication date: January 2017 Source:Ticks and Tick-borne Diseases, Volume 8, Issue 1 Author(s): Knut Eirik Eliassen, Dag Berild, Harald Reiso, Nils Grude, Karen Sofie Christophersen, Cecilie Finckenhagen, Morten Lindbæk The first stage of Lyme borreliosis (LB) is mainly the typical skin lesion, erythema migrans (EM), which is estimated to comprise 80–90% of all LB cases. However, the reporting of, and the actual incidence of LB varies throughout Europe. Studies from Sweden and Holland have found EM incidences varying from 53 to 464 EM/100,000 inhabitants/year. Under-reporting of LB is common and a coefficient of three to reach a realistic estimate is suggested. In Norway, it is mandatory to report only the second and third LB stages to the National Institute of Public Health. To find...


Wednesday 30 November 2016

IJERPH, Vol. 13, Pages 1194: Immunogenetic Markers Definition in Latvian Patients with Lyme Borreliosis and Lyme Neuroborreliosis

The aim of this study was to determine the human leukocyte antigen (HLA)-DRB1 alleles in two groups of patients in Latvia: patients with Lyme borreliosis and patients with Lyme neuroborreliosis. The study included 216 patients with Lyme borreliosis, 29 patients with Lyme neuroborreliosis and 282 control persons. All surveyed persons were residents of Latvia. The HLA-DR genotyping was performed by polymerase chain reaction- sequence specific primer (PCR-SSP). The predisposition to the Lyme borreliosis is associated with the HLA-DRB1*07, -DRB1*17(03), -DRB1*04, -DRB1*15(02) alleles. The allele -DRB1*11(05), -DRB1*14(06) and -DRB1*13(06) were significantly more frequent in controls. In-group with Lyme neuroborreliosis differences were found for the -DRB1*07 and -DRB1*04 alleles, but only HLA-...


Tuesday 29 November 2016

Progress in the molecular diagnosis of Lyme disease.

Authors: Ružić-Sabljić E, Cerar T Abstract INTRODUCTION: Current laboratory testing of Lyme borreliosis mostly relies on serological methods with known limitations. Diagnostic modalities enabling direct detection of pathogen at the onset of the clinical signs could overcome some of the limitations. Molecular methods detecting borrelial DNA seem to be the ideal solution, although there are some aspects that need to be considered. Areas covered: This review represent summary and discussion of the published data obtained from literature searches from PubMed and The National Library of Medicine (USA) together with our own experience on molecular diagnosis of Lyme disease. Expert commentary: Molecular methods are promising and currently serve as supporting diagnostic testing in Lyme ...


Monday 28 November 2016

The Potential of Omics Technologies in Lyme Disease Biomarker Discovery and Early Detection

This article reviews the findings within the field of omics relevant to LB and its prospective utility in developing an array of biomarkers that can be employed in LB diagnosis and detection particularly at the early disease stages. (Source: Infectious Diseases and Therapy)


Sunday 27 November 2016

Acarological Risk of Borrelia burgdorferi Sensu Lato Infections Across Space and Time in The Netherlands

Vector-Borne and Zoonotic Diseases , Vol. 0, No. 0. (Source: Vector-Borne and Zoonotic Diseases)

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Friday 25 November 2016

Established Population of Blacklegged Ticks with High Infection Prevalence for the Lyme Disease Bacterium, Borrelia burgdorferi Sensu Lato, on Corkscrew Island, Kenora District, Ontario.

Authors: Scott JD, Foley JE, Clark KL, Anderson JF, Durden LA, Manord JM, Smith ML Abstract We document an established population of blacklegged ticks, Ixodes scapularis, on Corkscrew Island, Kenora District, Ontario, Canada. Primers of the outer surface protein A (OspA) gene, the flagellin (fla) gene, and the flagellin B (flaB) gene were used in the PCR assays to detect Borrelia burgdorferi sensu lato (s.l.), the Lyme disease bacterium. In all, 60 (73%) of 82 adult I. scapularis, were infected with B. burgdorferi s.l. As well, 6 (43%) of 14 unfed I. scapularis nymphs were positive for B. burgdorferi s.l. An I. scapularis larva was also collected from a deer mouse, and several unfed larvae were gathered by flagging leaf litter. Based on DNA sequencing of randomly selected Borrelia ...


Friday 25 November 2016

The impact of temperature and precipitation on blacklegged tick activity and Lyme disease incidence in endemic and emerging regions

The incidence of Lyme disease shows high degrees of inter-annual variation in the northeastern United States, but the factors driving this variation are not well understood. Complicating matters, it is also po... (Source: Parasites and Vectors)


Thursday 24 November 2016

Pathogenetic implications of the age at time of diagnosis and skin location for acrodermatitis chronica atrophicans

Conclusions ACA is more likely to be diagnosed in older individuals than any other manifestation of Lyme borreliosis. ACA is more likely than EM to be localized anatomically to the extremities. Available data favor the hypothesis that ACA occurs most often on the extremities of older individuals because of predisposing age-related anatomic or physiologic changes, but more data are needed to define the latency period and other aspects of the pathogenesis of this skin condition. (Source: Ticks and Tick borne Diseases)


Thursday 24 November 2016

University of Sydney discovers 1500 viruses in insects

University of Sydney has discovered 1500 viruses in common insects, spiders, worms. New technology can also answer questions about the controversial Lyme disease. Surprising results released Thursday. (Source: the Mail online | Health)


Wednesday 23 November 2016

Use of tick-borne disease manual increases accuracy of tick identification among primary care providers in Lyme disease endemic areas

Publication date: Available online 23 November 2016 Source:Ticks and Tick-borne Diseases Author(s): Amber D. Butler, Meredith L. Carlson, Christina A. Nelson Given the high incidence of tick bites and tick-borne diseases in the United States, it is important for primary care providers to recognize common ticks and the pathogens they may transmit. If a patient has removed and saved an attached tick, identifying the tick helps guide clinical management and determine whether antibiotic prophylaxis for Lyme disease is appropriate. To investigate providers’ ability to recognize common ticks and the pathogens they may transmit, we asked 76 primary care providers from Lyme disease endemic areas to identify the common name or genus of preserved ticks found in their area. At baseline, 10.5%, 46....


Tuesday 22 November 2016

Linear Sclerodermoid Lupus Erythematosus Profundus in a Child

In this study, the authors present a 9-year-old girl with linear arrangement of subcutaneous nodules on her left forearm. Microscopic findings from 2 biopsies included lymphocytes at the dermoepidermal junction with mild interface dermatitis, a dense lymphocytic infiltrate that was concentrated around adnexae and subcutaneous fat in concert with thickened collagen bundles and mild widening of fibrous septae surrounding fat lobules. Although the clinical differential diagnosis included panniculitis or a sporotrichoid infection, 1 biopsy showed a dense lymphocytic infiltrate histologically bordered on that of cutaneous lymphoid hyperplasia or a late stage of Lyme disease, and a second also demonstrated more prominent sclerodermoid collagen bundles rendering the diagnosis of linear scleroderm...

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Tuesday 22 November 2016

Ability of an oral formulation of afoxolaner to protect dogs from Borrelia burgdorferi infection transmitted by wild Ixodes scapularis ticks.

In this study, all dogs treated with NexGard(®) 28days prior to challenge with wild caught I. scapularis ticks were protected from B. burgdorferi infection, while nine out of the ten untreated control dogs were infected. PMID: 27865266 [PubMed - in process] (Source: Comparative immunology, microbiology and infectious diseases.)


Tuesday 22 November 2016

Heterogeneity in the abundance and distribution of Ixodes ricinus and Borrelia burgdorferi (sensu lato) in Scotland: implications for risk prediction

Cases of Lyme borreliosis, a vector-borne zoonosis caused by bacteria in the Borrelia burgdorferi (sensu lato) species group, have increased in recent years in Europe. Knowledge of environmental factors associate... (Source: Parasites and Vectors)


Monday 21 November 2016

Molecular evidence for Toxoplasma gondii in feeding and questing Ixodes ricinus ticks

Publication date: Available online 21 November 2016 Source:Ticks and Tick-borne Diseases Author(s): Małgorzata Adamska, Bogumiła Skotarczak The aim of the present study was to detect Toxoplasma gondii in ticks collected from ponies and field vegetation and to determine the role of Shetland ponies as a potential reservoir host for T. gondii. A total of 1737 feeding Ixodes ricinus collected from 49 horses and 371 questing ticks were tested by PCR and sequencing for the presence and genotyping of T. gondii. All ticks were examined in a previous study to detect and identify pathogenic bacterial species. The aim of this study was also to detect co-infection of ticks with these bacteria and T. gondii. Genotyping of the sequenced B1 gene revealed that detected T. gondii strains represented gen...



Friday 18 November 2016

Commercial test kits for detection of Lyme borreliosis: a meta-analysis of test accuracy

(Source: International Journal of General Medicine)

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Wednesday 16 November 2016

Herbal Medicine for Lyme Disease and Other Tick-Borne Infections

Alternative and Complementary Therapies , Vol. 0, No. 0. (Source: Alternative and Complementary Therapies)


Wednesday 16 November 2016

Detection of Lyme disease and anaplasmosis pathogens via PCR in Pennsylvania deer ked

This study confirms the presence of B. burgdorferi and A. phagocytophilum in deer keds (Lipoptena cervi) removed from white‐tailed deer using PCR. Detection of these pathogens in deer ked represents a potential novel susceptibility of wildlife and also suggests the risk of transmission of these pathogens to humans and animals alike through the bite of an infected ectoparasite. This study represents the first instance in the U.S. of detection of tick‐borne pathogens in a member of the Hippoboscid family. (Source: Journal of Vector Ecology)


Wednesday 16 November 2016

Claims-Based Diagnostic Patterns of Patients Evaluated for Lyme Disease and Given Extended Antibiotic Therapy

Vector-Borne and Zoonotic Diseases , Vol. 0, No. 0. (Source: Vector-Borne and Zoonotic Diseases)


Wednesday 16 November 2016

Education on tick bite and Lyme borreliosis prevention, aimed at schoolchildren in the Netherlands: comparing the effects of an online educational video game versus a leaflet or no intervention

Lyme disease or Lyme borreliosis (LB) is the most common tick-borne disease both in the United States and Europe. Children, in particular, are at high risk of contracting LB. Since child-specific educational t... (Source: BMC Public Health)


Tuesday 15 November 2016

The 9 Sneaky Things That Are Causing Your Knee Pain

SPECIAL FROM Next Avenue Whether it came on suddenly when you were playing tennis or more gradually over many years, knee pain can keep you from doing even the most basic of activities. At the very least, it can limit your ability to move as easily or quickly, or sit in one place for an extended time.   Arthritis is the most common cause of knee pain for older adults, said Dr. Julie Switzer, an orthopedic surgeon at Regions Hospital in St. Paul, Minn. Arthritis comes in three main forms, she said: osteoarthritis, inflammatory arthritis and post-traumatic arthritis. We’ll examine these types, as well as other causes of knee pain, below. The others include Lyme arthritis, torn cartilage or ligament, tendinitis, bursitis, gout and spontaneous osteonecrosis of the knee. Then, we&...


Monday 14 November 2016

[Challenge of neuroborreliosis].

Authors: Spreer A, Rauer S, Wilking H, Fingerle V Abstract Lyme borreliosis is the most frequent tick-borne infection in Europe. It is a multisystemic disease affecting the skin, joints, heart, in rare cases the eyes and regularly the nervous system. Taking current clinical and microbiological guidelines into account, neuroborreliosis can in general be diagnosed and treated successfully. An appropriate guideline-conform antibiotic treatment is effective and in most cases recovery from acute neuroborreliosis is complete. Nevertheless, the evidence base regarding pharmacological treatment needs reform and improvement. Contrary to this scientifically based medical opinion, divergent opinions presented in the media cause uncertainty and confusion among patients and also some physicians...

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Monday 14 November 2016

Howard England from Essex asks Daily Mail if a Lyme disease test is necessary

Howard England from Essex consults our expert about his daughters fatigue, which may be connected to a tick bite she got in 2005. She was told the disease can only be treated in Germany. (Source: the Mail online | Health)


Friday 11 November 2016

A Density Map of the Tick-Borne Encephalitis and Lyme Borreliosis Vector Ixodes ricinus (Acari: Ixodidae) for Germany

The castor bean tick Ixodes ricinus (L.) is the principal vector for a variety of viral, bacterial, and protozoan pathogens causing a growing public-health issue over the past decades. However, a national density map of I. ricinus is still missing. Here, I. ricinus nymphs in Germany were investigated by compiling a high-resolution map depicting the mean annually accumulated nymphal density, as observed by monthly flagging an area of 100 m2. Input data comprise ticks collected at 69 sampling sites. The model domain covers an area of about 357,000 km2 (regional scale). Two negative binomial regression models were fitted to the data to interpolate the tick densities to unsampled locations using bioclimatic variables and land cover, which were selected according to their significance by the Ak...


Friday 11 November 2016

A Critical Appraisal of the Mild Axonal Peripheral Neuropathy of Late Neurologic Lyme Disease

In older studies, a chronic distal symmetric sensory neuropathy was reported as a relatively common manifestation of late Lyme disease in the United States. However, the original papers describing this entity had notable inconsistencies and certain inexplicable findings, such as reports that this condition developed in patients despite prior antibiotic treatment known to be highly effective for other manifestations of Lyme disease. More recent literature suggests that this entity is seen rarely, if at all. (Source: Diagnostic Microbiology and Infectious Disease)


Friday 11 November 2016

Expression of C-Reactive Protein and Serum Amyloid A in Early to Late Manifestations of Lyme Disease

Conclusions. These findings indicate that circulating CRP and SAA levels are highest when the concentration of spirochetes is greatest in skin and/or blood and that levels decline after the dissemination of the organism to extracutaneous sites in subsequent stages of infection. The data also suggest that antibiotic-refractory Lyme arthritis and post-treatment Lyme disease syndrome are associated with elevated CRP responses that are driven by inflammatory mechanisms distinct from those in active infection. (Source: Clinical Infectious Diseases)


Thursday 10 November 2016

Detection of borrelia genomospecies 2 in ixodes spinipalpis ticks collected from a rabbit in canada.

DETECTION OF BORRELIA GENOMOSPECIES 2 IN IXODES SPINIPALPIS TICKS COLLECTED FROM A RABBIT IN CANADA. J Parasitol. 2016 Nov 11; Authors: Scott JD, Clark KL, Foley JE, Anderson JF, Durden LA, Manord JM, Smith ML Abstract Lyme disease is a serious health problem with many patients requiring in-depth clinical assessment and extended treatment. In the present study, we provide the first records of the western blacklegged tick, Ixodes pacificus, and Ixodes spinipalpis parasitizing eastern cottontails, Sylvilagus floridanus. We also documented a triple co-infestation of 3 tick species (Ixodes angustus, I. pacificus, I. spinipalpis) feeding on an eastern cottontail. Notably, we discovered a unique member of the Lyme disease bacterium, Borrelia burgdorferi sensu lato (s.l.) in ...


Wednesday 9 November 2016

Phospholipidomic Analysis Reveals Changes in Sphingomyelin and Lysophosphatidylcholine Profiles in Plasma from Patients with Neuroborreliosis

AbstractIn recent years, the number of patients suffering from Lyme Disease (LD) has significantly increased. The most dangerous manifestation of LD is neuroborreliosis associated with invasion of the central nervous system byBorrelia burgdorferi. Phospholipids (PL) and their metabolites are involved in inflammation, which plays a dominant, but still unclear, role in the pathogenesis of neuroborreliosis. We analyzed the plasma PL profiles of neuroborreliosis patients (n = 8) and healthy volunteers (n = 8) using a lipidomic approach. Significant increases in the lysophosphatidylcholines LysoPtdCho 16:0 and LysoPtdCho 18:2 were observed. The plasma of neuroborreliosis patients appeared to have an increased relative abundance of sphingomyelin CerPCho d18:1/24:1 and a decrease in CerPCho d...

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Tuesday 8 November 2016

Antibody profiling of canine IgG responses to the OspC protein of the Lyme disease spirochetes supports a multivalent approach in vaccine and diagnostic assay development

In this study, the specificity of antibody (Ab) responses to OspC was profiled to define the antigenic determinants during infection and after vaccination. Several OspC variants or ‘types’ were screened with serum from SNAP4Dx C6 positive dogs and with serum from rabbits hyperimmunized with OspC proteins. The OspC type-specific nature of the Ab response revealed that variable domains of OspC are immunodominant during infection and upon vaccination. To assess the potential of OspC to elicit Ab in the context of a bacterin vaccine, OspC production in strains cultivated in vitro was assessed. Immunoblot and indirect immunofluorescent antibody analyses demonstrated that production is low and that only a subset of cells actively produce OspC in vitro, raising questions about the potential o...


Tuesday 8 November 2016

Seroprevalence of Borrelia burgdorferi, Anaplasma phagocytophilum, and Francisella tularensis Infections in Belgium: Results of Three Population-Based Samples

Vector-Borne and Zoonotic Diseases , Vol. 0, No. 0. (Source: Vector-Borne and Zoonotic Diseases)



Sunday 6 November 2016

No association between Borrelia burgdorferi antibodies and amyotrophic lateral sclerosis in a case –control study

ConclusionThis large case–control study provides evidence for a lack of association between B. burgdorferi antibodies and ALS, and therefore does not support the inclusion of routine testing for these antibodies in the diagnostic work‐up in patients with classical ALS. (Source: European Journal of Neurology)


Sunday 6 November 2016

Lyme in the coconut: Paediatric neuroborreliosis

(Source: Journal of Paediatrics and Child Health)

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Saturday 5 November 2016

Duration of Borrelia mayonii infectivity in an experimental mouse model for feeding Ixodes scapularis larvae

In this study, we demonstrate that an experimental spirochete host, the CD-1 strain outbred white mouse, can maintain active infection with B. mayonii for up to 1year: infected mice consistently yielded ear biopsies containing motile spirochetes from 29–375days after they were first infected via tick bite. Infection rates in resultant nymphal ticks varied greatly both over time for larvae fed on the same individual mouse at different time points after infection (2–42%) and for larvae fed on different mice at a given time point up to 8 months after infection (0–48%). Infection rates were lower in nymphs fed as larvae on mice 10–12 months after infection (2–3% for 5 mice and 9.8% for 1 mouse). In addition to ear biopsies, B. mayonii was detected from bladder, heart, and spinal cord...


Saturday 5 November 2016

Does Lyme disease exist in Australia?

Authors: Collignon PJ, Lum GD, Robson JM Abstract There is no convincing evidence that classic Lyme disease occurs in Australia, nor is there evidence that the causative agent, Borrelia burgdorferi, is found in Australian animals or ticks. Lyme disease, however, can be acquired overseas but diagnosed in Australia; most people presenting with laboratory-confirmed Lyme disease in Australia were infected in Europe. Despite the lack of evidence that Lyme disease can be acquired in Australia, growing numbers of patients, their supporters, and some politicians demand diagnoses and treatment according to the protocols of the "chronic Lyme disease" school of thought. Antibiotic therapy for chronic "Lyme disease-like illness" can cause harm to both the individual (eg, cannula-related intrav...


Friday 4 November 2016

Genes and age determine susceptibility to Lyme disease

People react very differently to an infection with the Borrelia bacterium that causes Lyme disease. Researchers have investigated this varying response, concluding that age, genetic disposition and previous Lyme infections play an important role. However, despite the large differences observed, the Borrelia bacterium has a clear effect on the immune system ’s energy regulation, opening up opportunities for research into better detection of Borrelia infections. (Source: ScienceDaily Headlines)


Wednesday 2 November 2016

T cells exacerbate Lyme borreliosis in TLR2-deficient mice

Carrie E. Lasky, Carmela Louise Pratt, Kinsey A Hilliard, Jacob J Jones, Charles Robert Brown (Source: Frontiers in Immunology)


Wednesday 2 November 2016

Identification and molecular survey of Borrelia burgdorferi sensu lato in sika deer (Cervus nippon) from Jilin Province, north-eastern China.

In this study, the existence and prevalence of Borrelia sp. in sika deer from four regions of Jilin Province in China was assessed. Seventy-one blood samples of sika deer were collected and tested by nested-PCRs based on 16S ribosomal RNA (16S rRNA), outer surface protein A (OspA), flagenllin (fla), and 5S-23S rRNA intergenic spacer (5S-23S rRNA) genes of B. burgdorferi s.l. Six (8.45%) samples were positive for Borrelia sp. based on sequences of 4 genes. The positive samples were detected 18 for 16S rRNA, 10 for OspA, 16 for fla and 6 for 5S-23S, with the positive rates 25.35 (95% CI=3.8-35.6), 14.08 (95% CI=3.0-21.6), 22.54 (95% CI=4.3-36.9) and 8.45 (95% CI=1.7-22.9), respectively. Sequence analysis of the positive PCR products revealed that the partial 4 genes sequences in this study w...


Wednesday 2 November 2016

Emily Muldoon told she was suffering depression discovers she has Lyme disease

Queensland woman Emily Muldoon, 27, has opened up about her long  undiagnosed battle with Lyme disease after she endured excruciating pain for a decade. (Source: the Mail online | Health)

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Tuesday 1 November 2016

Hemifacial Spasm From Lyme Disease: Antibiotic Treatment Points to the Cause

Abstract: A wide range of etiologies can cause hemifacial spasm (HFS), including infection. In this case report, a 44-year-old woman developed HFS and was explored surgically 7 years later. No abnormalities were found. Afterward, treatment of a surgical wound infection with an oral cephalosporin resulted in a temporary HFS remission that had never occurred previously. This antibiotic experience prompted further workup for an underlying infection, which ultimately led to diagnosis of Lyme disease. Presentation of HFS due to Lyme disease has not been reported. Because its diagnosis can be occult and antibiotic therapy can be both diagnostic and therapeutic, Lyme disease should be a consideration for cases of HFS. (Source: Clinical Neuropharmacology)

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Tuesday 1 November 2016

Controversies in Persistent (Chronic) Lyme Disease

The Centers for Disease Control and Prevention estimates that more than 300 000 new cases of Lyme disease occur each year in the United States and that 10% to 20% of these patients will remain symptomatic despite receiving appropriate antibiotic therapy. Many elements of the disease are poorly understood and have generated considerable controversy. This paper discusses the medical controversies related to posttreatment manifestations and their potential impact on infusion nurses. (Source: Journal of Infusion Nursing)


Monday 31 October 2016

Lyme Disease.

Authors: Weiss D, Weiss MF PMID: 27802470 [PubMed - in process] (Source: Annals of Internal Medicine)


Monday 31 October 2016

Functional and Genomic Architecture of Borrelia burgdorferi-Induced Cytokine Responses in Humans.

In conclusion, functional genomics approaches reveal the architecture of cytokine production induced by Borrelia infection of human primary leukocytes and suggest a connection between cellular glucose metabolism and Borrelia-induced cytokine production. PMID: 27818078 [PubMed - as supplied by publisher] (Source: Cell Host and Microbe)


Monday 31 October 2016

Improve Kidney Function With IV Laser Treatment

If you're one of the more than 20 million Americans who suffer from chronic kidney disease (CKD), your doctor has probably told you there isn't much they can do for you. Mainstream medicine doesn't have a cure for CKD. What they do have is a lot of drugs to treat the symptoms of it. And most of the drugs will leave you worse off than before you started taking them… Like ESAs, which are prescribed to treat anemia caused by chronic kidney disease. These dangerous drugs can cause strokes, heart attacks, blood clots and seizures. And if your kidneys fail, your only options are dialysis or a kidney transplant. It's enough to leave you feeling hopeless… But I'm here to tell you there IS hope. It's called intravenous laser blood therapy, or IV laser treatment. ...


Friday 7 October 2016

The eye and tick-borne disease in the United States

Purpose of review: Tick-borne diseases are increasing in incidence and geographic distribution. Several diseases endemic to the United States have ophthalmic manifestations, including the most common tick-borne disease, Lyme borreliosis. As ocular complaints may lead a patient to seek medical evaluation, it is important to be aware of the systemic and ophthalmic manifestations of tick-borne diseases in order to make the correct diagnosis. Recent findings: Vision-threatening ophthalmic manifestations are relatively common in Lyme disease and Rocky Mountain spotted fever. Ocular involvement is rare in babesiosis, tick-borne relapsing fever, Powassan encephalitis, ehrlichiosis, anaplasmosis, and Colorado tick fever. There are clear guidelines for diagnosis and treatment of Lyme disease; how...

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Wednesday 5 October 2016

Technical and clinical validation of three commercial real-time PCR kits for the diagnosis of neuroborreliosis in cerebrospinal fluid on three different real-time PCR platforms

This study reports the evaluation of the technical and clinical validation of the O-DiaBorburg kit (DIA),Borrelia burgdorferi PCR kit, ISEX (GENE), andBorrelia burgdorferi sensu lato Real-TM (SAC) for the diagnosis of neuroborreliosis in cerebrospinal fluid based on bothBorrelia DNA and CSF samples from patients with clinical suspicion of neuroborreliosis. This validation study was done by analysing the kits on the Rotorgene Q (RGQ), CFX96, and LightCycler480 (LC480). For all kits, the linear range was larger on RGQ than on CFX96 and LC480. A good reproducibility was obtained for all assays on all instruments. Storage at −20 °C resulted in a decreased reproducibility for SAC. Results of the limit of detection (LOD95) experiments indicated a better sensitivity than described in the kit ...


Tuesday 4 October 2016

RNA-Seq of < i > Borrelia burgdorferi < /i > in Multiple Phases of Growth Reveals Insights into the Dynamics of Gene Expression, Transcriptome Architecture, and Noncoding RNAs

by William K. Arnold, Christina R. Savage, Catherine A. Brissette, Janakiram Seshu, Jonathan Livny, Brian StevensonBorrelia burgdorferi, the agent of Lyme disease, differentially expresses numerous genes and proteins as it cycles between mammalian hosts and tick vectors. Insights on regulatory mechanisms have been provided by earlier studies that examinedB.burgdorferi gene expression patterns during cultivation. However, prior studies examined bacteria at only a single time point of cultivation, providing only a snapshot of what is likely a dynamic transcriptional program drivingB.burgdorferi adaptations to changes during culture growth phases. To address that concern, we performed RNA sequencing (RNA-Seq) analysis ofB.burgdorferi cultures at early-exponential, mid-exponential, and early-s...


Tuesday 4 October 2016

Molecular Detection of Tick-Borne Pathogens in Humans with Tick Bites and Erythema Migrans, in the Netherlands

ConclusionsBased on molecular detection techniques, the probability of infection with a tick-borne pathogen other than Lyme spirochetes after a tick bite is roughly 2.4%, in the Netherlands. Similarly, among patients with erythema migrans, the probability of a co-infection with another tick-borne pathogen is approximately 2.7%. How often these infections cause disease symptoms or to what extend co-infections affect the course of Lyme borreliosis needs further investigations. (Source: PLoS Neglected Tropical Diseases)

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Tuesday 4 October 2016

A Review of the Centers for Disease Control and Prevention ’s Guidelines for the Clinical Laboratory Diagnosis of Lyme Disease

The purpose of this paper is to review information regarding the current guidelines for the clinical laboratory diagnosis of Lyme disease as set forth by the Centers for Disease Control and Prevention (CDC) to chiropractic physicians and to discuss the clinical utility of this testing. (Source: Journal of Chiropractic Medicine)


Tuesday 4 October 2016

Homogeneous Inflammatory Gene Profiles Induced in Human Dermal Fibroblasts in Response to the Three Main Species of < i > Borrelia  burgdorferi < /i > sensu lato

In this study, using whole transcriptome microarray chips, we aimed to compare the transcriptional response of normal human dermal fibroblasts stimulated by 3Borrelia burgdorferi sensu lato strains belonging to 3 main pathogenic species (B.afzelii,B.garinii andB.burgdorferi sensu stricto) in order to determine whether “species-related” inflammatory pathways could be identified. The threeBorrelia strains tested exhibited similar transcriptional profiles, and no species-specific fingerprint of transcriptional changes in fibroblasts was observed. Conversely, a common core of chemokines/cytokines (CCL2, CXCL1, CXCL2, CXCL6, CXCL10, IL-6, IL-8) and interferon-related genes was stimulated by all the 3 strains. Dermal fibroblasts appear to play a key role in the cutaneous infection withBorrel...


Sunday 2 October 2016

< i > Borrelia burgdorferi < /i > Induces TLR2-Mediated Migration of Activated Dendritic Cells in an < i > Ex Vivo < /i > Human Skin Model

by Lauren M. K. Mason, Alex Wagemakers, Cornelis van ‘t Veer, Anneke Oei, Wouter J. van der Pot, Kalam Ahmed, Tom van der Poll, Teunis B. H. Geijtenbeek, Joppe W. R. HoviusBorrelia burgdorferi is transmitted into the skin of the host where it encounters and interacts with two dendritic cell (DC) subsets; Langerhans cells (LCs) and dermal DCs (DDCs). These cells recognize pathogens via pattern recognition receptors, mature and migrate out of the skin into draining lymph nodes, where they orchestrate adaptive immune responses. In order to investigate the response of skin DCs during the early immunopathogenesis of Lyme borreliosis, we injectedB.burgdorferi intradermally into full-thickness human skin and studied the migration of DCs out of the skin, the activation profile and phenotype of m...


Saturday 1 October 2016

Lyme disease in modern Ireland: the importance of home imaging.

Authors: Forman E, Rice M, Neylon O PMID: 27685494 [PubMed - as supplied by publisher] (Source: Ir Med J)


Friday 30 September 2016

A novel glycan modifies the flagellar filament proteins of the oral bacterium Treponema denticola

This article is protected by copyright. All rights reserved. Swimming with sugar: We demonstrate that the flagellar filament proteins of oral bacterium Treponema denticola are modified with a novel glycan (a C7‐acylated pseudaminic acid derivative, m/z 451.2) and that such a modification is essential for flagellar assembly and motility. (Source: Molecular Microbiology)


Friday 30 September 2016

Climate change and the epidemiology of selected tick ‐borne and mosquito‐borne diseases: update from the International Society of Dermatology Climate Change Task Force

Abstract Climate change refers to variation in the climate of a specific region or globally over time. A change has been reported in the epidemiology of tick‐ and mosquito‐borne diseases in recent decades. Investigators have postulated that this effect may be associated with climate change. We reviewed the English‐language literature describing changes in the epidemiology of specific tick‐ and mosquito‐borne diseases, including the tick‐borne diseases of Lyme disease, tularemia, Crimean‐Congo hemorrhagic fever, Mediterranean spotted fever, and Rocky Mountain spotted fever and the mosquito‐borne diseases of dengue, malaria, West Nile virus infection, Ross River virus disease, and Barmah Forest virus disease. We postulate that the changing epidemiology of tick‐ and mosquito...


Friday 30 September 2016

The putative Walker A and Walker B motifs of Rrp2 are required for the growth of Borrelia burgdorferi

This article is protected by copyright. All rights reserved. Rrp2 acts in concert with BosR to activate σ54‐dependent rpoS transcription in Borrelia burgdorferi. In contrast to canonical bacterial enhancer binding proteins, Rrp2 is essential for the growth of B. burgdorferi. We demonstrate that the Walker A and B motifs constituting ATP binding and hydrolysis activities of Rrp2 are required for borrelial growth, suggesting that the Walker motifs are involved in Rrp2's control over another unknown RpoS‐independent gene product(s) associated with cell replication. (Source: Molecular Microbiology)

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Thursday 29 September 2016

Pulmonary mucosa-associated lymphoid tissue lymphoma revisited

We read with great interest the review of Borie et al. [1] on pulmonary lymphoma of the mucosa-associated lymphoid tissue (MALT). We agree with the hypothesis that chronic antigen stimulation of microbial origin may lead to the development of pulmonary MALT lymphoma. Indeed, MALT lymphoma has been associated with various chronic infections in extrapulmonary localisations. This link has previously been demonstrated between Helicobacter pylori infection and gastric MALT lymphoma, and suggested with Campylobacter jejuni, Chlamydia psittaci and Borrelia burgdorferi with small intestine lymphoma, ocular annexa lymphoma and cutaneous lymphoma, respectively. Similarly a link has recently been suggested between infection with Achromobacter xylosoxidans and pulmonary MALT lymphoma [2]. (Source: Eur...


Thursday 29 September 2016

Bilateral Facial Paralysis: A 13-Year Experience

Conclusions: Bilateral facial palsy is a rare medical condition, and treatment often requires a multidisciplinary approach. The authors outline diagnostic and therapeutic algorithms of a tertiary care center to provide clinicians with a systematic approach to managing these complicated patients. (Source: Plastic and Reconstructive Surgery)


Thursday 29 September 2016

Efficacy and safety of pharmacological treatments for Lyme neuroborreliosis in children: a systematic review

Many aspects of pharmacological treatment of Lyme neuroborreliosis in children, such as choice of drug, dosage, and duration are subject to intense debates, leading to uncertainties in patients ’ parents and he... (Source: BMC Neurology)


Wednesday 28 September 2016

Ability of an oral formulation of afoxolaner to protect dogs from Borrelia burgdorferi infection transmitted by wild Ixodes scapularis ticks

In this study, all dogs treated with NexGard® 28days prior to challenge with wild caught I. scapularis ticks were protected from B. burgdorferi infection, while nine out of the ten untreated control dogs were infected. (Source: Comparative Immunology, Microbiology and Infectious Diseases)

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Wednesday 28 September 2016

BORRELIA-BABESIA HOMOCHORD (Babesia Microti, Borrelia Burgdorferi Nosode) Liquid [Deseret Biologicals, Inc.]

Updated Date: Sep 28, 2016 EST (Source: DailyMed Drug Label Updates)


Tuesday 27 September 2016

Hide and Seek: How Lyme Disease Spirochetes Overcome Complement Attack

Peter Kraiczy (Source: Frontiers in Immunology)


Monday 26 September 2016

Post-Lyme Arthritis: More than Lyme? (CME/CE)

(MedPage Today) -- Persistent joint symptoms may represent a new-onset autoimmune disease (Source: MedPage Today Geriatrics)


Saturday 24 September 2016

Borrelia burgdorferi DNA absent, multiple Rickettsia spp. DNA present in ticks collected from a teaching forest in North Central Florida

Publication date: Available online 24 September 2016 Source:Ticks and Tick-borne Diseases Author(s): Katherine Sayler, Jessica Rowland, Carisa Boyce, Emma Weeks Tick-borne diseases are an emerging public health threat in the United States. In Florida, there has been public attention directed towards the possibility of locally acquired Borrelia burgdorferi sensu stricto, the causative agent of Lyme disease, in association with the lone star tick. The aim of this study was to determine the prevalence of ticks and the pathogens they carry and potentially transmit, such as B. burgdorferi, in a highly utilized teaching and research forest in North Central Florida. Ticks were collected by dragging and flagging methods over a four month period in early 2014, identified, and tested by PCR for mul...


Friday 23 September 2016

What 1989 And The Golden Girls Tell Us About Medicine Today

Today, 1989 may be most associated with Taylor Swift: It is the album that won her a second Grammy for Album of the Year. Not only that, it happens to be the year Swift was born--such a long, long time ago! People under 35 have no personal memory of 1980s pop culture, which is ironic since Swift's album in part pays homage to it. In the real 1989 (no offense to Swift and the 10 co-producers who made the album), all sorts of revolutions took place: Mr. Gorbachev tore down that pesky wall, for example. America's greatest antagonist, the Soviet Union, collapsed in 1989. Brazil conducted its first democratic presidential election since 1960. And so on. Today, it's hard to say whether America's greatest existential threat may be Vladimir Putin or his Number-One American Fan, Donald Trump...


Friday 23 September 2016

Nested coevolutionary networks shape the ecological relationships of ticks, hosts, and the Lyme disease bacteria of the Borrelia burgdorferi (s.l.) complex

The bacteria of the Borrelia burgdorferi (s.l.) (BBG) complex constitute a group of tick-transmitted pathogens that are linked to many vertebrate and tick species. The ecological relationships between the pathoge... (Source: Parasites and Vectors)


Thursday 22 September 2016

Canon buys $40m stake in T2 Biosystems

Canon U.S.A. (NYSE:CAJ) said today it made a $40 million dollar equity investment into diagnostic developer T2 Biosystems Inc. (NSDQ:TTOO), giving Canon a 19.9% stake. Canon said it purchased approximately $40 million of T2’s stock at $6.56 per share through a private placement. The investment isn’t the 1st pairing for Canon and T2, as both companies have been collaborating to develop a diagnostic test panel for rapidly detecting Lyme disease since February 2015. “We recognize that both T2 Biosystems and Canon U.S.A. are aligned in working towards the same goal and as such, we are pleased to strengthen our relationship and look forward to bringing future innovative diagnostic products to market that can improve patient health. Investments to companies like T2 is anot...

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Wednesday 21 September 2016

Identification and functional characterization of a pyrokinin neuropeptide receptor in the Lyme disease vector, Ixodes scapularis

This study sets the stage for future research to examine the prospective tissue targets identified in order to resolve the physiological roles of this family of peptides in Ixodid ticks. (Source: Peptides)


Monday 19 September 2016

Evaluation of two assays for CXCL13 analysis in cerebrospinal fluid for laboratory diagnosis of Lyme neuroborreliosis

We evaluated the diagnostic performance of two assays, one bead‐based assay and one enzyme‐linked immunosorbent assay (ELISA), for the determination of CXCL13 levels in cerebrospinal fluid (CSF) from patients with suspected Lyme neuroborreliosis (LNB). Patients investigated for LNB were retrospectively included (n = 132): 35 with definite LNB, 8 with possible LNB with CSF pleocytosis but normal antibody index (AI), 6 with possible LNB with elevated AI but no CSF pleocytosis and 83 non‐LNB patients. CSF samples had been drawn before antibiotic treatment and were analysed for CXCL13 by Quantikine ELISA (R&D Systems) and recomBead (Mikrogen). Receiver operating characteristic analyses based on the definite LNB and non‐LNB groups revealed a best performance cut‐off of 56 pg/mL fo...

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Monday 19 September 2016

Ehrlichia sp. infection in carthorses of low-income owners, Southern Brazil.

Authors: Vieira TS, Vieira RF, Krawczak FS, Soares HS, Guimarães AM, Barros-Filho IR, Marcondes M, Labruna MB, Biondo AW, Vidotto O Abstract Although well established in dogs, Ehrlichia sp. infection has been scarcely reported in horses. The aim was to perform a comprehensive serological and molecular survey for the detection of Ehrlichia spp. in carthorses from Southern Brazil. Blood samples from 190 carthorses from Paraná State were sampled. Horses were also tested for Borrelia burgdorferi and Anaplasma phagocytophilum. Anti-Ehrlichia sp. antibodies were detected by a commercial rapid ELISA, and immunofluorescence antibody assays (IFA) with E. chaffeensis and E. canis as crude antigens. The molecular and phylogenetic analysis of Ehrlichia sp. was based on 16S rRNA and dsb genes...


Saturday 17 September 2016

Analysis of the human population bitten by Ixodes scapularis ticks in Quebec, Canada: Increasing risk of Lyme disease

Publication date: Available online 13 September 2016 Source:Ticks and Tick-borne Diseases Author(s): Salima Gasmi, Nicholas H. Ogden, Patrick A. Leighton, L. Robbin Lindsay, Karine Thivierge Ixodes scapularis, the main vector of Borrelia burgdorferi, the spirochetal agent of Lyme disease, is expanding its range in southern Canada and bringing risk to the public from Lyme disease. The aims of this study were to (i) describe how risk of Lyme disease in Quebec, Canada, has changed from 2008 to 2014 by analysis of the number of tick submissions, the geographic scope of ticks submitted and the prevalence of B. burgdorferi in ticks removed from people and submitted through the Quebec passive tick surveillance program and (ii) explore whether exposure to ticks is influenced by age and sex. Ticks...


Saturday 17 September 2016

Evidence of rapid changes in Lyme disease awareness in Canada

Publication date: Available online 18 September 2016 Source:Ticks and Tick-borne Diseases Author(s): Cécile Aenishaenslin, Catherine Bouchard, Jules K. Koffi, Yann Pelcat, Nicholas H. Ogden Lyme disease (LD) is emerging in Canada. A key preventive strategy is promoting the adoption by the general public of personal preventive behaviors regarding tick bites. The aim of this study was to measure the changes in public awareness toward ticks and LD before and after the launch of a national communication campaign in Canada using data from two surveys conducted in March and December 2014. The results show a significant increase in awareness of LD after compared to before the campaign, but also suggest that the importance of this increase is not equal amongst Canadian regions. Moreover, respond...


Thursday 15 September 2016

Autoimmune Arthritides, Rheumatoid Arthritis, Psoriatic Arthritis, or Peripheral Spondyloarthropathy, Following Lyme Disease

Conclusion: Systemic autoimmune joint diseases, RA, PsA/SpA, may follow Lyme disease. Development of polyarthritis after antibiotic‐treated erythema migrans, previous psoriasis, or low‐titer B. burgdorferi antibodies are clues to the correct diagnosis. This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)


Thursday 15 September 2016

Prevalence of Borrelia burgdorferi sensu lato in synanthropic rodents in two rural communities of Yucat án, México.

CONCLUSIONS: We concluded that rodents have a high prevalence of B. burgdorferi s.l. infection, and both species of rodents, M. musculus and R. rattus, might be playing an important role in the maintenance of this bacterium in rural communities of Yucatán, México. PMID: 27622631 [PubMed - in process] (Source: Biomedica : Revista del Instituto Nacional de Salud)

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Thursday 15 September 2016

Is ‘concerning’ high temperature LYME disease? This Morning's Dr Sara explains

DR SARA KAYAT has given a second opinion to a caller concerned she could be suffering with Lyme disease. (Source: Daily Express - Health)


Wednesday 14 September 2016

[Tick-borne encephalitis in a child in a nonendemic country: A case report].

Authors: Levy M, Abi-Warde MT, Rameau AC, Fafi-Kremer S, Hansmann Y, Fischbach M, Higel L Abstract Tick-borne encephalitis (TBE) is an arbovirus induced by tick-borne encephalitis virus (TBEV) transmitted by tick bite. The disease is rare in France (two to three cases per year) but endemic zones extend from Western Europe to the east coast of Asia (10,000-15,000 cases per year). An 8-year-old boy was admitted to our pediatric ward in Strasbourg (France) for febrile headache with diplopia. Four days after a tick bite, he declared a febrile headache together with maculopapular rash on the elbows, knees, and cheeks. Fourteen days after the outbreak of symptoms, he showed confusion, drowsiness, and binocular diplopia. Brain MRI was normal and the electroencephalogram found diffuse slow...


Wednesday 14 September 2016

Is The Shocking News of the Sugar Industry's Influence Over Harvard Researchers Really Shocking?

Hey, Sugar, pay no attention to the man behind the curtain. Today, the Journal of the American Medical Association dropped an alleged bombshell when it disclosed that the sugar industry lobby influenced research on coronary heart disease by effectively bribing Harvard researchers to promote the theory that dietary fat, and not sugar, causes heart disease. The story is trending on Facebook at this very moment, and the JAMA Facebook post states that "Policymaking committees should consider giving less weight to food industry-funded studies, and include mechanistic and animal studies as well as studies appraising the effect of added sugars on multiple CHD biomarkers and disease development." All of this is well and good (actually, no, not really), but I've got to ask you--are you really s...


Tuesday 13 September 2016

Analysis of the human population bitten by Ixodes scapularis ticks in Qu ébec, Canada: increasing risk of Lyme disease

Publication date: Available online 13 September 2016 Source:Ticks and Tick-borne Diseases Author(s): Salima Gasmi, Nicholas H. Ogden, Patrick A. Leighton, L. Robbin Lindsay, Karine Thivierge Ixodes scapularis, the main vector of Borrelia burgdorferi, the spirochetal agent of Lyme disease, is expanding its range in southern Canada and bringing risk to the public from Lyme disease. The aims of this study were to i) describe how risk of Lyme disease in Quebec, Canada, has changed from 2008 to 2014 by analysis of the number of tick submissions, the geographic scope of ticks submitted and the prevalence of B. burgdorferi in ticks removed from people and submitted through the Quebec passive tick surveillance program and ii) explore whether exposure to ticks is influenced by age and sex. Ticks w...


Tuesday 13 September 2016

Lyme disease: the promise of Big Data, companion diagnostics and precision medicine

(Source: Infection and Drug Resistance)


Sunday 11 September 2016

Evaluation of the C6 Lyme Enzyme Immunoassay for the Diagnosis of Lyme Disease in Children and Adolescents

Conclusions. For children and adolescents undergoing evaluation for Lyme disease, the C6 EIA could guide initial clinical decision making, although a supplemental immunoblot should still be performed. (Source: Clinical Infectious Diseases)

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Sunday 11 September 2016

Borrelial Lymphocytoma in Adult Patients

Conclusions. BL is a rare manifestation of early localized LB. Fourteen-day antibiotic treatment, as used for erythema migrans, is effective. (Source: Clinical Infectious Diseases)


Friday 9 September 2016

Do Invisible Health Problems Exist?

This morning, I awoke to find that I had been copied on dozens of Twitter message exchanges among several people who were discussing the pathology of Borrelia burgdorferi, the bacterium that causes Lyme disease, among human beings and mice. My first thought was "Seriously?! It's too early for this!" My second thought was "well, David, your Twitter sure has evolved from your pre-Lyme days when you used it mostly to promote vapid celebrity interviews." As I began my morning caffeine ritual and read through each of the messages, I gained a new appreciation for some of the real complexities of "invisible" illnesses. If you are connected with anyone on social media who lives with a chronic ailment, you've probably seen memes such as the ones peppered throughout this post. People who suf...


Thursday 8 September 2016

It ' s Past Time For Lyme Disease Vaccine, Says Vaccine Developer Stanley Plotkin

With more than 300,000 new infections of Lyme disease each year, a vaccine is warranted, argues researcher. (Source: Forbes.com Healthcare News)


Wednesday 7 September 2016

[Lyme disease: The French Infectious Diseases Society's statement].

Authors: Hansmann Y, Chirouze C, Tattevin P, Alfandari S, Caumes E, Christmann D, Salomon J, Michelet C, Rabaud C, Roblot F, Société de pathologie infectieuse de langue française PMID: 27592140 [PubMed - as supplied by publisher] (Source: Medecine et Maladies Infectieuses)


Wednesday 7 September 2016

The Nucleotide Excision Repair Pathway Protects Borrelia burgdorferi from Nitrosative Stress in Ixodes scapularis Ticks

Travis J. Bourret, Kevin A. Lawrence, Jeff A. Shaw, Tao Lin, Steven J. Norris, Frank C. Gherardini (Source: Frontiers in Microbiology)


Tuesday 6 September 2016

Steroid use linked to worse outcomes in Lyme disease-associated facial paralysis

Researchers have found that patients who were prescribed corticosteroids as part of treatment for Lyme disease-associated facial paralysis had worse long-term outcomes of regaining facial function than those who were prescribed antibiotic therapy alone. Based on these findings the researchers urge caution in prescribing corticosteroids to patients with acute Lyme disease-associated facial paralysis. (Source: ScienceDaily Headlines)

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Tuesday 6 September 2016

Expression Profiles of Toll-Like Receptors in the Differentiation of an Infection with Borrelia burgdorferi Sensu Lato Spirochetes

AbstractThe similarity of Lyme borreliosis to other diseases and its complex pathogenesis present diagnostic and therapeutic difficulties. The changes that occur at the cellular and molecular levels after aBorrelia sp. infection still remain poorly understood. Therefore, the present study focused on the expression ofTLR andTLR-signaling genes in human dermal fibroblasts in the differentiation of an infection withBorrelia burgdorferi sensu lato spirochetes. Normal human dermal fibroblasts were cultured with the spirochetes ofBorrelia burgdorferi sensu stricto,Borrelia afzelii andBorrelia garinii. Total RNA was extracted from the cells using TRIzol reagent. The analysis of the expression profiles ofTLRs andTLR-related genes was performed using commercially available oligonucleotide microarra...


Tuesday 6 September 2016

Longer-Term Therapy for Symptoms Attributed to Lyme Disease

New England Journal of Medicine,Volume 375, Issue 10, Page 997-998, September 2016. (Source: New England Journal of Medicine)

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Tuesday 6 September 2016

Need for a New Lyme Disease Vaccine

New England Journal of Medicine,Volume 375, Issue 10, Page 911-913, September 2016. (Source: New England Journal of Medicine)


Tuesday 6 September 2016

Groundbreaking Lyme Researcher: 'We Need To Do A Better Job At Communicating'

The following Q&A is a continuation of an interview with Tara Moriarty, proprietor of the Moriarty Lab, an infectious diseases research lab that studies primarily Borrelia burgdorferi (Bb) the bacterium that causes Lyme disease. Moriarty is the principal investigator of a new academic paper from the University of Toronto that details the mechanism by which Bb "crawl" through the body -- a scholarly article that turned out to be unexpectedly popular. Tara Moriarty (Photo by Jeff Comber) How do you think your findings about the biomechanics of Lyme disease bacteria may affect treatment of the disease? Your research shows that Bb uses specialized adhesive bonds to "crawl" along the insides of blood vessels.  Tara Moriarty: Absolutely, targeting this adhesion mechanism could be very i...


Tuesday 6 September 2016

Steroid use linked to worse outcomes in Lyme disease-associated facial paralysis

(Massachusetts Eye and Ear Infirmary) Researchers from Massachusetts Eye and Ear/Harvard Medical School have found that patients who were prescribed corticosteroids as part of treatment for Lyme disease-associated facial paralysis had worse long-term outcomes of regaining facial function than those who were prescribed antibiotic therapy alone. Based on these findings, which were published online today in Laryngoscope, the researchers urge caution in prescribing corticosteroids to patients with acute Lyme disease-associated facial paralysis. (Source: EurekAlert! - Infectious and Emerging Diseases)


Monday 5 September 2016

Not All Erythema Migrans Lesions are Lyme Disease

Lyme disease is the number one arthropod-transmitted disease in the U.S., and one of the diagnostic criteria for the illness is development of an erythematous bull ’s eye rash around a tick bite which may expand over time, hence the term erythema migrans. However, there are other erythema migrans-like rashes such as those from a condition known as southern tick-associated rash illness. This paper describes a patient with an erythema migrans-like lesion simil ar to that associated with Lyme disease, resulting from a bite by a nymphal stage lone star tick, Amblyomma americanum. (Source: The American Journal of Medicine)


Friday 2 September 2016

Critical Evaluation of the Linkage Between Tick-Based Risk Measures and the Occurrence of Lyme Disease Cases

The nymphal stage of the blacklegged tick, Ixodes scapularis Say, is considered the primary vector to humans in the eastern United States of the Lyme disease spirochete Borrelia burgdorferi sensu stricto. The abundance of infected host-seeking nymphs is commonly used to estimate the fundamental risk of human exposure to B. burgdorferi, for the purpose of environmental risk assessment and as an outcome measure when evaluating environmentally based tick or pathogen control methods. However, as this tick-based risk measure does not consider the likelihoods of either human encounters with infected ticks or tick bites resulting in pathogen transmission, its linkage to the occurrence of Lyme disease cases is worth evaluating. In this Forum article, we describe different tick-based risk measures,...


Friday 2 September 2016

Modeling the Geographic Distribution of Ixodes scapularis and Ixodes pacificus (Acari: Ixodidae) in the Contiguous United States

In addition to serving as vectors of several other human pathogens, the black-legged tick, Ixodes scapularis Say, and western black-legged tick, Ixodes pacificus Cooley and Kohls, are the primary vectors of the spirochete (Borrelia burgdorferi) that causes Lyme disease, the most common vector-borne disease in the United States. Over the past two decades, the geographic range of I. pacificus has changed modestly while, in contrast, the I. scapularis range has expanded substantially, which likely contributes to the concurrent expansion in the distribution of human Lyme disease cases in the Northeastern, North-Central and Mid-Atlantic states. Identifying counties that contain suitable habitat for these ticks that have not yet reported established vector populations can aid in targeting limite...


Friday 2 September 2016

Evidence for Personal Protective Measures to Reduce Human Contact With Blacklegged Ticks and for Environmentally Based Control Methods to Suppress Host-Seeking Blacklegged Ticks and Reduce Infection with Lyme Disease Spirochetes in Tick Vectors and Rodent Reservoirs

In the 1980s, the blacklegged tick, Ixodes scapularis Say, and rodents were recognized as the principal vector and reservoir hosts of the Lyme disease spirochete Borrelia burgdorferi in the eastern United States, and deer were incriminated as principal hosts for I. scapularis adults. These realizations led to pioneering studies aiming to reduce the risk for transmission of B. burgdorferi to humans by attacking host-seeking ticks with acaricides, interrupting the enzootic transmission cycle by killing immatures infesting rodent reservoirs by means of acaricide-treated nesting material, or reducing deer abundance to suppress tick numbers. We review the progress over the past three decades in the fields of: 1) prevention of human–tick contact with repellents and permethrin-treated cloth...


Friday 2 September 2016

Why Is An Obscure Study About Lyme Disease-Causing Bacteria So Popular Online?

"Who knew there would be so much interest in a biomechanics paper??!!" Those are the words--and the multiple exclamation points--of Tara Moriarty, proprietor of the Moriarty Lab, an infectious diseases research lab that studies primarily Borrelia burgdorferi (Bb) the bacterium that causes Lyme disease. Moriarty is the principal investigator of a new academic paper from the University of Toronto that details the mechanism by which Bb "crawl" through the body. Scientific American is among the many mainstream outlets that discussed the findings, which may represent a major step in making the ever-gray world of Lyme disease science more black and white. Understanding the movement of an infectious disease agent may seem unnecessarily technical to many people, but Lyme disease patients a...


Thursday 1 September 2016

The TamB ortholog of Borrelia burgdorferi interacts with the β‐barrel assembly machine (BAM) complex protein BamA

This article is protected by copyright. All rights reserved. Borrelia burgdorferi encodes a TamB‐like protein. TamB proteins from Proteobacteria interact with TamA to form the translocation and assemble module (TAM). Spirochetes and many other organisms, however, do not contain a TamA protein, although they encode TamB homologs. Here, we show that the TamB homolog from B. burgdorferi interacts with the BamA protein of the β‐barrel assembly machine (BAM) and suggest this may be a common interaction in organisms that lack TamA and a TAM. (Source: Molecular Microbiology)

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Thursday 1 September 2016

So THAT'S When You Should See A Doctor For A Bug Bite

The Question: When does a bug bite require serious medical attention? The Answer: Sometimes that pesky mosquito bite just needs a little hydrocortisone cream and time to heal. But occasionally, it’s not so simple. While most bug bites and stings are harmless, some can be dangerous if not treated properly — especially if you have an undiagnosed allergy to a particular bug venom or if that bug is a disease carrier. The summer months seem to be stocked with extra critters crawling and buzzing around us, upping the chances that you, a friend or a family member might need a dermatologist’s expertise. Here’s how the experts determine the difference between a nuisance and a health concern that requires attention. One of the first steps to differentiating between a ...


Wednesday 31 August 2016

Impact of white ‐tailed deer on the spread of Borrelia burgdorferi

This study examines the pathogen prevalence rate of Borrelia in adult Ixodes scapularis (Ixodida: Ixodidae), the black‐legged tick, collected from white‐tailed deer and compares it with pathogen prevalence rates in adult ticks gathered by dragging vegetation in two contiguous counties west of the Hudson Valley in upstate New York. In both Broome and Chenango Counties, attached and unattached ticks harvested from white‐tailed deer had significantly lower prevalences of B. burgdorferi than those collected from vegetation. No attached ticks on deer (n = 148) in either county, and only 2.4 and 7.3% of unattached ticks (n = 389) in Broome and Chenango Counties, respectively, were harbouring the pathogen. This contrasts with the finding that 40.8% of ticks in Broome County and 46...


Wednesday 31 August 2016

The modular nature of the β‐barrel assembly machinery, illustrated in Borrelia burgdorferi

This article is protected by copyright. All rights reserved. (Source: Molecular Microbiology)

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Wednesday 31 August 2016

Steroid use in Lyme disease ‐associated facial palsy is associated with worse long‐term outcomes

ConclusionAn association between corticosteroid use in acute LDFP and worse long‐term facial function outcomes has been demonstrated. Care should be taken in differentiating viral or idiopathic facial palsy (e.g., Bell palsy) from LDFP. Level of Evidence4. Laryngoscope, 2016 (Source: The Laryngoscope)


Wednesday 31 August 2016

Demonstration of the Ability of a Canine Lyme Vaccine to Reduce the Incidence of Histological Synovial Lesions Following Experimentally-Induced Canine Lyme Borreliosis

Publication date: Available online 31 August 2016 Source:Veterinary Immunology and Immunopathology Author(s): Deborah A. Grosenbaugh, Daniel R. Rissi, Paula M. Krimer Lyme disease in dogs can be effectively prevented by vaccination against antigens expressed by the spirochete Borrelia burgdorferi during transmission by the tick vector Ixodes sp. Lyme vaccine efficacy has traditionally been based on indicators of infection following wild-caught tick challenge whereas most other types of vaccine are required to demonstrate protection from clinical signs of disease. In this vaccination-challenge study we sought to demonstrate the ability of a nonadjuvanted, outer surface protein A (OspA) vaccine to protect from infection and to prevent synovial lesions consistent with Borreliosis. Thirty, pu...


Wednesday 31 August 2016

Poster 362 Osmotic Demyelination in Lyme Disease: A Case Report

Arpit Arora: I Have No Relevant Financial Relationships To Disclose (Source: PM and R)


Wednesday 31 August 2016

Lyme Disease Surveillance in New York State: an Assessment of Case Underreporting

Summary Despite the mandatory nature of Lyme disease (LD) reporting in New York State (NYS), it is believed that only a fraction of the LD cases diagnosed annually are reported to public health authorities. Lack of complete LD case reporting generally stems from (i) lack of report of provider‐diagnosed cases where supportive laboratory testing is not ordered or results are negative (i.e. provider underreporting) and (ii) incomplete case information (clinical laboratory reporting only with no accompanying clinical information) such that cases are considered ‘suspect’ and not included in national and statewide case counts (i.e. case misclassification). In an attempt to better understand LD underreporting in NYS, a two‐part study was conducted in 2011 using surveillance data from thre...


Wednesday 31 August 2016

Lyme disease risk in dogs in New Brunswick.

This study assessed the seroprevalence of anti-Borrelia burgdorferi antibodies in New Brunswick dogs. Testing of 699 serum samples from dogs across the province revealed a 6% province-wide seropositivity, more than 6 times higher than that found in 2008. The rapid increase in seropositivity indicates increased Lyme disease risk to both canine and human health. PMID: 27587892 [PubMed - in process] (Source: The Canadian Veterinary Journal)


Monday 29 August 2016

Occurrence of Borrelia burgdorferi Sensu Lato in Ixodes ricinus Ticks with First Identification of Borrelia miyamotoi in Vojvodina, Serbia

Vector-Borne and Zoonotic Diseases , Vol. 0, No. 0. (Source: Vector-Borne and Zoonotic Diseases)


Thursday 25 August 2016

Biomechanics of Borrelia burgdorferi Vascular Interactions

Publication date: Available online 25 August 2016 Source:Cell Reports Author(s): Rhodaba Ebady, Alexandra F. Niddam, Anna E. Boczula, Yae Ram Kim, Nupur Gupta, Tian Tian Tang, Tanya Odisho, Hui Zhi, Craig A. Simmons, Jon T. Skare, Tara J. Moriarty Systemic dissemination of microbes is critical for progression of many infectious diseases and is associated with most mortality due to bacterial infection. The physical mechanisms mediating a key dissemination step, bacterial association with vascular endothelia in blood vessels, remain unknown. Here, we show that endothelial interactions of the Lyme disease spirochete Borrelia burgdorferi under physiological shear stress mechanistically resemble selectin-dependent leukocyte rolling. Specifically, these interactions are mediated by tra...


Thursday 25 August 2016

How Lyme disease bacteria spread through the body

Researchers have developed a live-cell-imaging-based system that provides insights into how Lyme disease bacteria latch onto and move along the inside surface of blood vessels to reach key destinations in the body where they may be able to persist longer and avoid treatment. Ironically, the same strategies that these bacteria use to spread through the body are also used by immune cells to protect against infectious disease. (Source: ScienceDaily Headlines)

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Thursday 25 August 2016

Something to Grapple with: How Wily Lyme Disease Prowls the Body

The sneaky germ uses a mechanism like that of white blood cells to reach vulnerable tissues and hide from antibiotics -- Read more on ScientificAmerican.com (Source: Scientific American)

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Thursday 25 August 2016

Research note: Lyme bacteria mark out cell division locations for their progeny

Among bacteria, the spirochetes are characterized by their spiral shape and remarkable length — as much 50 times longer than most other bacteria. This can make cell elongation and division a laborious process. One of those spirochetes, Borrelia burgdorferi, which causes Lyme Disease, has evolved an unusual way of doing this process: Borrelia cells mark the location where their daughters wi ll divide before dividing themselves.  (Source: Yale Science and Health News)


Thursday 25 August 2016

How Lyme disease bacteria spread through the body

(Cell Press) Researchers have developed a live-cell-imaging-based system that provides insights into how Lyme disease bacteria latch onto and move along the inside surface of blood vessels to reach key destinations in the body where they may be able to persist longer and avoid treatment. Ironically, the same strategies that these bacteria use to spread through the body are also used by immune cells to protect against infectious disease. The study appears Aug. 25 in Cell Reports. (Source: EurekAlert! - Infectious and Emerging Diseases)


Wednesday 24 August 2016

Drought ’ s Good News – Fewer Ticks

CONCORD, N.H. (AP) — The drought conditions that have gripped much of the Northeastern U.S. this summer appear to have a silver lining — fewer ticks. From Maine to Rhode Island, researchers say they expect tick numbers to be down from previous years especially for the blacklegged ticks, known as deer ticks, which transmit Lyme disease. It’s too early to say, however, whether fewer ticks could mean a decline in Lyme disease cases. About 30,000 confirmed cases are reported each year across the country and those numbers have steadily risen. Scientists and state health agencies say they won’t be able to provide an accurate assessment until later this year. “I’m confident that ticks took it on the chin this summer,” said University of Rhode Island’s Thoma...


Wednesday 24 August 2016

Safety and efficacy of intravitreal dexamethasone implants in the management of macular edema secondary to infectious uveitis

Conclusion: In this small case series of eyes with macular edema secondary to infectious uveitis, treatment with dexamethasone intravitreal implants was not associated with reactivation of the infectious ocular disease. Furthermore, significant improvements in visual acuity and macular thickness were observed in our patients. (Source: RETINA)



Tuesday 23 August 2016

Articular Manifestations in Patients With Lyme Disease

Conclusions Lyme disease patients showing articular manifestations should be included in the diagnosis of articular affections in areas of high risk of hard tick bite, in order to establish a suitable and early treatment and to avoid sequels. (Source: Reumatologia Clinica)


Tuesday 23 August 2016

Borrelia mayonii sp. nov., a member of the Borrelia burgdorferi sensu lato complex, detected in patients and ticks in the upper midwestern United States.

Authors: Pritt BS, Respicio-Kingry LB, Sloan LM, Schriefer ME, Replogle AJ, Bjork J, Liu G, Kingry LC, Mead PS, Neitzel DF, Schiffman E, Hoang Johnson DK, Davis JP, Paskewitz SM, Boxrud D, Deedon A, Lee X, Miller TK, Feist MA, Steward CR, Theel ES, Patel R, Irish CL, Petersen JM Abstract Lyme borreliosis (LB) is a multisystem disease caused by spirochetes in the Borrelia burgdorferi sensu lato (Bbsl) genospecies complex. We previously described a novel Borrelia species (type strain MN14-1420T) that causes LB among patients with exposures to ticks in the upper midwestern United States. Patients infected with the novel species demonstrated high levels of spirochetemia and differing clinical symptoms as compared to other Bbsl genospecies. The organism was detected from human specimens...


Tuesday 23 August 2016

A fluid circumstance: Lyme spinal arthritis

A previously unreported sign and related symptoms overshadowed the revelatory clue in a patient with early infection. A 25-year-old man from New England awoke with posterior neck pain that progressively worsened over the next 3 days. He sought treatment at a general medicine clinic where he had an unremarkable physical examination and reported no significant medical history. Results from a complete blood count with differential, a complete metabolic panel, and a cervical spine x-ray were normal. (Source: The American Journal of Medicine)


Tuesday 23 August 2016

Malaria-Like Parasite From Ticks Spreading To U.K. Through Dogs

Mepron, a thick liquid antimicrobial drug used to treat Babesia and malaria, as well as a fungal infection called Pneumocystitis carinii. In 2011, the United Kingdom stopped requiring that dogs brought into the country be inspected for ticks. Earlier this year, several dogs tested positive for babesia, a malaria-like disease transmitted to ticks that previously had only been found in foreign. These dogs had never left the U.K. While babesiosis is a new worry to U.K. dog owners, it's been a threat to human beings for years -- it just hasn't become a health-scare-of-the-week like Zika, West Nile, avian and swine flu. Most people have never heard of it. Babesia microti, the protozoan that causes babesiosis, occurs throughout continental Europe and Asia, as well as throughout New England a...

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Saturday 20 August 2016

Contributing Op-Ed Writer: A Natural Cure for Lyme Disease

Infections have surged, and an out-of-whack ecosystem may be to blame. (Source: NYT Health)


Friday 19 August 2016

Lyme Disease

(Source: eMedicineHealth.com)


Thursday 18 August 2016

Evidence that BosR (BB0647) Is a Positive Autoregulator in Borrelia burgdorferi [Molecular Pathogenesis]

Borrelia burgdorferi survives in nature through a complex tick-mammalian life cycle. During its transit between ticks and mammalian hosts, B. burgdorferi must dramatically alter its outer surface profile in order to interact with and adapt to these two diverse niches. It has been established that the regulator BosR (BB0647) in B. burgdorferi plays important roles in modulating borrelial host adaptation. However, to date, how bosR expression itself is controlled in B. burgdorferi remains largely unknown. Previously, it has been shown that DNA sequences upstream of BosR harbor multiple sites for the binding of recombinant BosR, suggesting that BosR may influence its own expression in B. burgdorferi. However, direct experimental evidence supporting this putative autoregulation of BosR has bee...

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Tuesday 16 August 2016

422 Establishing and validating a new flow cytometric method for diagnosis of Lyme borreliosis

Serological antibody detection tests are standard diagnostic procedure for Lyme disease. Indirect detection of pathogens is performed by ELISA and Immunoblot technique. A new flow cytometric method was developed, which detects human antibodies in serum and provides quantitative results. Our goal was to test out this method and to compare the results with those of the established methods. 101 sera from patients, who presented at the Department of Dermatology and Allergy Biederstein with a clinical diagnosis of Lyme disease were analysed for Borrelia antibodies using both the Immunoblot method (Borrelia ViraStripe ® IgG, IgM Test) and the flow cytometric method (SERION Multianalyt™ Borrelia burgdorferi IgG, IgM test). (Source: Journal of Investigative Dermatology)


Tuesday 16 August 2016

Yale-Trained Doctor Refutes Dangerous Misinformation Given by CDC's Dr. Paul Mead on Fox 5 Lyme Special

This study evaluated antibiotic vs placebo. The study was terminated early due to the determined likelihood that a beneficial effect would not be found. When this was critically analyzed with biostatistical methods, an article was published which I believe demonstrates that Klempner's study was so poorly designed and analyzed that in order for a treatment effect to have been observed, the antibiotic treated patients would have had to improve to a level of health which was a full standard deviation better than the average health of the general population. It's a reasonable hope for antibiotics to return a patient to a somewhat normal life; it's not a reasonable hope that they would improve that patient's health status to better than average. The second study was by Krupp. It showed a reduc...


Monday 15 August 2016

Growth pattern of Borrelia burgdorferi [Microbiology]

Agents that cause Lyme disease, relapsing fever, leptospirosis, and syphilis belong to the phylum Spirochaetae—a unique lineage of bacteria most known for their long, spiral morphology. Despite the relevance to human health, little is known about the most fundamental aspects of spirochete growth. Here, using quantitative microscopy to track peptidoglycan... (Source: Proceedings of the National Academy of Sciences)


Thursday 11 August 2016

Emerging borreliae – Expanding beyond Lyme borreliosis

Publication date: Available online 12 August 2016 Source:Molecular and Cellular Probes Author(s): Sally J. Cutler, Eva Ruzic-Sabljic, Aleksandar Potkonjak Lyme borreliosis (or Lyme disease) has become a virtual household term to the exclusion of other forgotten, emerging or re-emerging borreliae. We review current knowledge regarding these other borreliae, exploring their ecology, epidemiology and pathological potential, for example, for the newly described B. mayonii. These bacteria range from tick-borne, relapsing fever-inducing strains detected in some soft ticks, such as B. mvumii, to those from bat ticks resembling B. turicatae. Some of these emerging pathogens remain unnamed, such as the borrelial strains found in South African penguins and some African cattle ticks. Others, such as...


Thursday 11 August 2016

A Souvenir From France: Acrodermatitis Chronica Atrophicans Presenting in the United States.

Authors: Correa-Selm LM, Bronsnick T, Rao BK, Kirkorian AY, Marcus A, Cha J Abstract A 70-year-old man was referred by his rheumatologist to our dermatology clinic for evaluation of dermatitis on his right arm that appeared 3 months earlier. The skin lesion was asymptomatic and the patient denied current systemic symptoms, including fever, chills, and joint pain; however, 10 months prior to this presentation he experienced arthritis in the left knee. At that time, Borrelia serology revealed positive IgG (6.07; <0.8 negative, 0.8 to 0.99 borderline, ≥1 positive) and negative IgM titers. The patient had not received treatment for Lyme disease in the past. He was referred to rheumatology for evaluation of possible Lyme disease but did not follow up until 10 months later. The arth...


Monday 8 August 2016

Spirochetes flagellar collar protein FlbB has astounding effects in orientation of periplasmic flagella, bacterial shape, motility, and assembly of motors in Borrelia burgdorferi

Summary Borrelia burgdorferi, the causative agent of Lyme disease, is a highly motile spirochete, and motility, which is provided by its periplasmic flagella, is critical for every part of the spirochete's enzootic life cycle. Unlike externally flagellated bacteria, spirochetes possess a unique periplasmic flagellar structure called the collar. This spirochete‐specific novel component is linked to the flagellar basal body; however, nothing is known about the proteins encoding the collar or their function in any spirochete. To identify a collar protein and determine its function, we employed a comprehensive strategy that included genetic, biochemical, and microscopic analyses. We found that BB0286 (FlbB) is a novel flagellar motor protein, which is located around the flagellar basal body....

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Monday 8 August 2016

Investigating the potential role of non-vls genes on linear plasmid 28 –1 in virulence and persistence by Borrelia burgdorferi

The lp28-1 plasmid is required for persistent infection by the Lyme disease spirochete, Borrelia burgdorferi. Mutational studies on this plasmid have shown that the vls locus is important for antigenic variation ... (Source: BMC Microbiology)


Thursday 4 August 2016

Live-vaccinia virus encapsulation in pH-sensitive polymer increases safety of a reservoir-targeted Lyme disease vaccine by targeting gastrointestinal release.

Authors: Kern A, Zhou CW, Jia F, Xu Q, Hu LT Abstract The incidence of Lyme disease has continued to rise despite attempts to control its spread. Vaccination of zoonotic reservoirs of human pathogens has been successfully used to decrease the incidence of rabies in raccoons and foxes. We have previously reported on the efficacy of a vaccinia virus vectored vaccine to reduce carriage of Borrelia burgdorferi in reservoir mice and ticks. One potential drawback to vaccinia virus vectored vaccines is the risk of accidental infection of humans. To reduce this risk, we developed a process to encapsulate vaccinia virus with a pH-sensitive polymer that inactivates the virus until it is ingested and dissolved by stomach acids. We demonstrate that the vaccine is inactive both in vitro and in ...


Thursday 4 August 2016

Validation of Random Sampling as an Estimation Procedure for Lyme Disease Surveillance in Massachusetts and Minnesota

Summary Many disease surveillance programs, including the Massachusetts Department of Public Health and the Minnesota Department of Health, are challenged by marked increases in Lyme disease (LD) reports. The purpose of this study was to retrospectively analyse LD reports from 2005 through 2012 to determine whether key epidemiologic characteristics were statistically indistinguishable when an estimation procedure based on sampling was utilized. Estimates of the number of LD cases were produced by taking random 20% and 50% samples of laboratory‐only reports, multiplying by 5 or 2, respectively, and adding the number of provider‐reported confirmed cases. Estimated LD case counts were compared to observed, confirmed cases each year. In addition, the proportions of cases that were male, we...


Tuesday 2 August 2016

Should Women Have Breast Implants Removed?

It was a story with a bit of irony, as well as ominous health warnings. Crystal Hefner, the 30-year-old wife of Playboy magazine mogul Hugh Hefner, announced in a story in People magazine last month that she'd had her breast implants removed because they were making her sick. Hefner posted a photo of her post-surgery self on Instagram with the caption, "Using 2016 to reclaim my health and embrace and love myself for the real me." The former model, now a DJ, was diagnosed a few months back with Lyme disease. Her symptoms included intolerance to foods and beverages as well as back, neck, and shoulder pain. Hefner also suffered from cognitive dysfunction (brain fog, memory loss), stunted hair growth, fatigue, burning bladder pain, low immunity, and recurring infections and problems with h...


Sunday 31 July 2016

Ehrlichia sp. infection in carthorses of low-income owners, Southern Brazil

Publication date: October 2016 Source:Comparative Immunology, Microbiology and Infectious Diseases, Volume 48 Author(s): Thállitha S. Vieira, Rafael F. Vieira, Felipe S. Krawczak, Herbert S. Soares, Ana M. Guimarães, Ivan R. Barros-Filho, Mary Marcondes, Marcelo B. Labruna, Alexander W. Biondo, Odilon Vidotto Although well established in dogs, Ehrlichia sp. infection has been scarcely reported in horses. The aim was to perform a comprehensive serological and molecular survey for the detection of Ehrlichia spp. in carthorses from Southern Brazil. Blood samples from 190 carthorses from Paraná State were sampled. Horses were also tested for Borrelia burgdorferi and Anaplasma phagocytophilum. Anti-Ehrlichia sp. antibodies were detected by a commercial rapid ELISA, and immunofluorescence an...


Sunday 31 July 2016

Reversible corticospinal tract hyperintensities in neurologic Lyme disease

A 60-year-old man presented with an ataxic and spastic gait with paraparesis, having reported a tick bite. Brain MRI depicted bilateral corticospinal tract hyperintensities (figure). He had a mild lymphocytic meningitis (12 leukocytes/mm3, proteinorachia 1.48 g/L). ELISA was positive for Lyme disease in serum (immunoglobulin G [IgG] 176 UI and immunoglobulin M <4 UI) and CSF (IgG 300 UI) with an intrathecal synthesis (index of CSF/serum-specific antibodies equal to 16 using ELISA [normal value <1.5]). Western blot was positive for Lyme-specific antibodies in serum (18, 22, 32, 41, 60, and 75 kDa) and CSF (41 and 60 kDa). Syphilis serology was negative. After treatment (IV ceftriaxone 2 g daily for 4 weeks), gait improved and brain MRI was normal. This MRI pattern has been previously ...


Sunday 31 July 2016

Molecular survey on the presence of zoonotic arthropod-borne pathogens in wild red deer (Cervus elaphus)

Publication date: August 2016 Source:Comparative Immunology, Microbiology and Infectious Diseases, Volume 47 Author(s): Valentina Virginia Ebani, Guido Rocchigiani, Fabrizio Bertelloni, Simona Nardoni, Alessandro Leoni, Sandro Nicoloso, Francesca Mancianti To estimate the prevalence of some zoonotic tick-borne pathogens in red deer (Cervus elaphus) living in Italian areas with high risk of arthropod exposure, blood samples from 60 red deer were tested by PCR for A. phagocytophilum, Borrelia burgdorferi s.l., Coxiella burnetii, Francisella tularensis, and piroplasms. Thirty-four (56.67%) animals resulted positive for one or more pathogens. In particular, 24 (40%) red deer were positive for A. phagocytophilum, 16 (26.67%) for Babesia divergens, 6 (10%) for C. burnetii, 2 (3.33%) for B. burg...

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Sunday 31 July 2016

Molecular survey on the presence of zoonotic arthropod-borne pathogens in wild red deer (Cervus elaphus).

Authors: Ebani VV, Rocchigiani G, Bertelloni F, Nardoni S, Leoni A, Nicoloso S, Mancianti F Abstract To estimate the prevalence of some zoonotic tick-borne pathogens in red deer (Cervus elaphus) living in Italian areas with high risk of arthropod exposure, blood samples from 60 red deer were tested by PCR for A. phagocytophilum, Borrelia burgdorferi s.l., Coxiella burnetii, Francisella tularensis, and piroplasms. Thirty-four (56.67%) animals resulted positive for one or more pathogens. In particular, 24 (40%) red deer were positive for A. phagocytophilum, 16 (26.67%) for Babesia divergens, 6 (10%) for C. burnetii, 2 (3.33%) for B. burgdorferi s.l. No positive reaction was observed for F. tularensis. Thirteen (21.67%) animals resulted co-infected by two or three pathogens. Red deer ...


Sunday 31 July 2016

Identification of B ‐cell epitopes of Borrelia burgdorferi outer surface protein C by screening a phage‐displayed gene fragment library

ABSTRACT Outer surface protein C of Borrelia stimulates remarkable immune responses during early infection and is currently considered as a leading diagnostic and vaccine candidate. Sensitivity and specificity of serological test based on whole protein OspC is still an issue in the diagnosis of Lyme disease. The minimal B‐cell epitopes are key in the development of reliable immunodiagnostic tool. Using OspC fragments displayed on phage particles (phage library) and anti‐OspC antibodies isolated from sera of naturally infected patients we identified six OspC epitopes capable of distinguishing between LD patient and healthy control sera. Three epitopes are located at N‐terminus (OspC E1 aa19‐27, OspC E2 aa38‐53, OspC E3 aa62‐66) and three at C‐terminal end (OspC E4 aa155‐163,...


Friday 29 July 2016

Characterizing Lyme Disease Surveillance in an Endemic State

Summary Lyme disease (LD) is the most common vector‐borne disease in Maryland and the United States. Surveillance for LD is valuable for understanding the burden of the disease, particularly to assess whether the disease is spreading and to appreciate who is affected. However, not all cases of LD in Maryland are reported, and surveillance practices vary across each of Maryland's 24 local health departments (LHDs). To better understand this variability and to systematically characterize the surveillance process, we surveyed Maryland's LHDs regarding LD surveillance. The Maryland Local Health Department Lyme Disease Surveillance Survey has been administered annually since 2011. Questions asked each year included whether all LD reports are investigated or only a subset, and how many reports...


Friday 29 July 2016

C6 EIA testing can guide Lyme disease treatment in children

The C6 Lyme enzyme immunoassay is an effective diagnostic tool for children who are being tested for Lyme disease, according to Susan C. Lipsett, MD, and her associates. Of the 944 samples collected... (Source: Clinical Neurology News)

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Friday 29 July 2016

Countrywide serological evaluation of canine prevalence for Anaplasma spp., Borrelia burgdorferi (sensu lato), Dirofilaria immitis and Ehrlichia canis in Mexico

Canine vector-borne diseases (CVBD) have become a major concern for canine and human public health. The aim of the study described here is to add epidemiological data regarding four pathogens responsible for C... (Source: Parasites and Vectors)

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Tuesday 26 July 2016

Fatigue in Patients with Erythema Migrans

Fatigue is a common symptom in patients with Lyme disease. (Source: Diagnostic Microbiology and Infectious Disease)


Sunday 24 July 2016

Evaluation of Six Recombinant Proteins for Serological Diagnosis of Lyme Borreliosis in China

Conclusion Three recombinant antigens, OspC B.g, OspC B.a, and VlsE B.a, were useful for ELISAs of LB. Additionally, the interaction between OspC B.a and Fla B.g should be examined in future research. (Source: Biomedical and Environmental Sciences)


Friday 22 July 2016

"It's A Scandal" -Daryl Hall on Doctors Denying Chronic Lyme

Growing up a musically-obsessed child in the 80's, Daryl Hall was one of my biggest inspirations. A masterful, inventive songwriter with an ocean of soul, he set me on the path to being an artist, to never waste a word, and to sing because I mean it. With six number ones and five additional top ten hits throughout the 70's and 80's Daryl Hall and John Oates are the number one duo in music history. Still at the top of his game at 69 years old, Daryl has won legions of new fans with his hit MTV Live show Live From Daryl's House. In February of 2015, at my very sickest from chronic Lyme and Bartonella, after it was missed by eleven NYC doctors, I was homebound and in heart failure. On one of those terrifying, bleary days I caught the last half of a Dan Rather interview with Daryl. Near the...


Friday 22 July 2016

When Lyme disease isn't caught early, fallout can be scary

Undetected cases of Lyme disease can leave patients with a mysterious and debilitating array of symptoms years later < div class="feedflare" > < a href="http://feeds.cbsnews.com/~ff/CBSNewsHealth?a=FrWRfhEp_T4:KFYundsh-w0:w--LzT5DBIM" > < img src="http://feeds.feedburner.com/~ff/CBSNewsHealth?i=FrWRfhEp_T4:KFYundsh-w0:w--LzT5DBIM" border="0" > < /img > < /a > < a href="http://feeds.cbsnews.com/~ff/CBSNewsHealth?a=FrWRfhEp_T4:KFYundsh-w0:yIl2AUoC8zA" > < img src="http://feeds.feedburner.com/~ff/CBSNewsHealth?d=yIl2AUoC8zA" border="0" > < /img > < /a > < a href="http://feeds.cbsnews.com/~ff/CBSNewsHealth?a=FrWRfhEp_T4:KFYundsh-w0:F7zBnMyn0Lo" > < img src="http://feeds.feedburner.com/~ff/CBSNewsHealth?i=FrWRfhEp_T4:KFYundsh-w0:F7zBnMyn0Lo" border="0" > < /img > < /a > < a href="http://feeds.c...


Thursday 21 July 2016

Infections of the Brain and Meninges

Imaging findings for the various typical bacteria infecting the CNS are nonspecific and require correlation with laboratory tests to establish a definitive diagnosis. Mycobacterial and spirochetal infections have a clinical presentation and imaging appearance different from those of typical bacteria. Therefore, the following sections first discuss the various stages of pyogenic infections that occur with the majority of bacteria, followed by a description of mycobacterial (tuberculosis) and spirochetal (Lyme disease) infections (Source: Seminars in Roentgenology)


Thursday 21 July 2016

Lyme disease: You can ' t blame the deer

The last decades the disease Lyme borreliosis that is spread by ticks has been increasing, but this increase cannot be explained by the increasing deer population only, say researchers. (Source: ScienceDaily Headlines)


Wednesday 20 July 2016

Feasibility of a simple microsieve-based immunoassay platform.

In this report, the feasibility of creating a microsieve-based immunoassay platform was explored. Microsieves containing 5μm pores were coupled with poly-acrylic acid chains, and then mounted into a plastic holder to enable rapid reagent exchanges via a wicking mechanism. The mounted microsieves were coated with infectious disease-related antigens at [2.5 and 25μg/mL], [20 and 50μg/mL], and [20 and 100μg/mL] to facilitate detection of serum-derived human antibodies against Rubella (3-day measles), B. burgdorferi (Lyme disease), or T. pallidum (syphilis), respectively. The prototype microsieve-based immunoassay platform was able to distinguish positive control sera containing antibodies against Rubella, T. pallidum, and B. burgdorferi from negative control sera with similar qualitative ...


Wednesday 20 July 2016

Geographical differences in seroprevalence of Borrelia burgdorferi antibodies in Norway, 2011 –2013

Publication date: July 2016 Source:Ticks and Tick-borne Diseases, Volume 7, Issue 5 Author(s): Didrik F. Vestrheim, Richard A. White, Ingeborg S. Aaberge, Audun Aase Detection of specific antibodies against Borrelia burgdorferi sensu lato is a useful aid for the diagnosis of Lyme borreliosis. However, antibodies are present in the general population. The seroprevalence increase with age, and varies according to the prevalence of infected ticks. We performed a seroprevalence study of IgM and IgG antibody reactivity against B. burgdorferi sensu lato in Norway by age-groups and geography, in order to provide a reference set of seroprevalence to inform the interpretation of positive test results. We used two commercially available enzyme immuno assays (EIA) and a multiplexed bead assay t...

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Wednesday 20 July 2016

HtrA, a Temperature- and Stationary Phase-Activated Protease Involved in Maturation of a Key Microbial Virulence Determinant, Facilitates Borrelia burgdorferi Infection in Mammalian Hosts [Bacterial Infections]

High-temperature requirement protease A (HtrA) represents a family of serine proteases that play important roles in microbial biology. Unlike the genomes of most organisms, that of Borrelia burgdorferi notably encodes a single HtrA gene product, termed BbHtrA. Previous studies identified a few substrates of BbHtrA; however, their physiological relevance could not be ascertained, as targeted deletion of the gene has not been successful. Here we show that BbhtrA transcripts are induced during spirochete growth either in the stationary phase or at elevated temperature. Successful generation of a BbhtrA deletion mutant and restoration by genetic complementation suggest a nonessential role for this protease in microbial viability; however, its remarkable growth, morphological, and structural de...


Wednesday 20 July 2016

Kris Kristofferson's Lyme disease misdiagnosed as Alzheimer's

The actor/songwriter struggled with memory issues thought to be dementia, but it turned out to be caused by tick-borne illness (Source: Health News: CBSNews.com)


Wednesday 20 July 2016

Taking The Battle Against Lyme Disease Ticks To The Backyard

Scientists have tested all sorts of strategies to keep Lyme disease ticks from biting us. One is to make it less likely you'll cross paths with the critters in your yard. Sawdust mulch, anyone? (Source: NPR Health and Science)

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Wednesday 20 July 2016

Lyme Disease: The Pharmacist ' s Role Lyme Disease: The Pharmacist ' s Role

Learn about the transmission, diagnosis, and treatment of Lyme disease and its complications in this overview. < br / > < i > U.S. Pharmacist < /i > (Source: Medscape Pathology Headlines)


Wednesday 20 July 2016

Scientists review methods to prevent bites, suppress ticks that transmit Lyme disease

Decades of scientific literature on the effectiveness of various methods of preventing bites and controlling ticks that transmit Lyme disease has been reviewed by a research team, and outlined in a new report. (Source: ScienceDaily Headlines)


Wednesday 20 July 2016

Lyme Disease: The Pharmacist's RoleLyme Disease: The Pharmacist's Role

Learn about the transmission, diagnosis, and treatment of Lyme disease and its complications in this overview. U.S. Pharmacist (Source: Medscape Today Headlines)


Wednesday 20 July 2016

CDC scientists review methods to prevent bites and suppress ticks that transmit Lyme disease

(Entomological Society of America) Dr. Lars Eisen and Marc Dolan of the US Centers for Disease Control and Prevention have reviewed decades of scientific literature on the effectiveness of various methods of preventing bites and controlling ticks that transmit Lyme disease. Their findings are published in the Journal of Medical Entomology. (Source: EurekAlert! - Infectious and Emerging Diseases)


Tuesday 19 July 2016

Field-Adapted Spot Test for Evaluating Materials Treated with Permethrin Insect Repellent

Military uniforms and mosquito nets are treated with permethrin, a repellent and insecticide used for personal protection against biting flies, mosquitoes, and other disease-carrying insects. Vector-borne diseases such as malaria, leishmaniasis (a parasitic infection spread by sandflies), Zika virus, West Nile virus, Lyme disease, and more can be diminished if treated nets or clothing containing the proper amount of permethrin are utilized. Washing and wear depletes the insecticide on the material, eventually rendering it ineffective. Currently, there are no commercially available colorimetric (color-changing) tests available to gauge the amount of permethrin left in fabrics after use and repeated washes. CDC researchers developed a rapid and simple technique using a reagent to quantify th...


Monday 18 July 2016

Long-term antibiotics after ceftriaxone did not improve quality of life in persistent Lyme disease.

Authors: Meyerhoff J PMID: 27429317 [PubMed - in process] (Source: Annals of Internal Medicine)

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Monday 18 July 2016

Paired Real-Time PCR Assays for Detection of Borrelia miyamotoi in North American Ixodes scapularis and Ixodes pacificus (Acari: Ixodidae)

Publication date: Available online 18 July 2016 Source:Ticks and Tick-borne Diseases Author(s): Christine B. Graham, Mark A. Pilgard, Sarah E. Maes, Andrias Hojgaard, Rebecca J. Eisen Borrelia miyamotoi is an emerging, tick-borne human pathogen. In North America, it is primarily associated with Ixodes scapularis and Ixodes pacificus, two species known to bite humans. Here we describe the development and evaluation of a pair of real-time TaqMan PCR assays designed to detect B. miyamotoi in North American ticks. We sought to achieve sensitivity to B. miyamotoi strains associated with ticks throughout North America, the full genetic diversity of which is unknown, by targeting sequences that are largely conserved between B. miyamotoi strains from the eastern United States and geneticall...


Monday 18 July 2016

T2 Biosystems, Bayer ink blood disorder deal

T2 Biosystems (NSDQ:TTOO) said today that it inked a deal with Bayer (ETR:BAYN) for research on blood coagulation disorders. The deal calls for T2 to provide its T2MR magnetic resonance-based diagnostic device to Bayer for a research program for drug and biomarker discovery in hemostasis. “We are very enthusiastic about our collaboration with Bayer and the important validation it represents for our T2MR technology in the field of hemostasis,” T2 CEO John McDonough said in prepared remarks. “Together with Bayer, we look forward to continuing the exploration of the clinical potential of our platform to provide improved patient care in this area of significant unmet need.” The companies have been working together for the last year and recently extended the collabo...

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Thursday 14 July 2016

Global Tn ‐seq analysis of carbohydrate utilization and vertebrate infectivity of Borrelia burgdorferi

Summary Borrelia burgdorferi maintains a complex life cycle between tick and vertebrate hosts. Although some genes have been identified as contributing to bacterial adaptation in the different hosts, the list is incomplete. In this manuscript, we report the first use of transposon mutagenesis combined with high‐throughput sequencing (Tn‐seq) in B. burgdorferi. We utilize the technique to investigate mechanisms of carbohydrate utilization in B. burgdorferi and the role of carbohydrate metabolism during mouse infection. We performed genetic fitness analyses to identify genes encoding factors contributing to growth on glucose, maltose, mannose, trehalose and N‐acetyl‐glucosamine. We obtained insight into the potential functions of proteins predicted to be involved in carbohydrate util...


Thursday 14 July 2016

Students' attitudes to tick risks.

CONCLUSION: Differences in preferences between the two nations appeared in many areas, e.g. the Czechs felt more threatened by all kind of risks and suffered from Lyme disease more frequently. Gaps can still be found in both the knowledge and behaviour among the respondents. It can be expected that the general public knowledge of this issue is rather limited in comparison with the students participating in the study, who are systematically educated in the field. PMID: 27660864 [PubMed - as supplied by publisher] (Source: Annals of Agricultural and Environmental Medicine : AAEM)


Thursday 14 July 2016

First molecular evidence of [i]Borrelia burgdorferi[/i] sensu lato in goats, sheep, cattle and camels in Tunisia.

This study provides the first insight into the presence of B. burgdorferi s.l. DNA in ruminants in Tunisia, and demonstrates that host species such as goats and sheep may play an important role in natural Lyme disease cycles in this country. PMID: 27660865 [PubMed - as supplied by publisher] (Source: Annals of Agricultural and Environmental Medicine : AAEM)


Thursday 14 July 2016

Course and Outcome of Early European Lyme Neuroborreliosis (Bannwarth Syndrome): Clinical and Laboratory Findings

Conclusions. Our patients had fewer pretreatment neurological complications (PFP, pareses) than reported for Bannwarth syndrome decades ago, probably as the result of earlier recognition and prompt antibiotic treatment. Unfavorable outcome was rare and was predicted by the continued presence of symptoms 14 days after commencement of treatment. (Source: Clinical Infectious Diseases)


Tuesday 12 July 2016

New York News Team And Yale-Educated Doctor Question CDC's Lyme Denial

Late last month, FOX5NY broadcast "Lyme and Reason," a precedent-setting news special dedicated to the Lyme disease epidemic. The show was a success by many measures, including--most importantly by TV production standards--ratings wise. The strong viewership reflects a strong interest in learning more about Lyme disease. More and more, people are discovering that they know someone whose life has been profoundly affected by Lyme. More and more, people are discovering that they themselves have been living with undiagnosed Lyme for years. Now the FOX5NY team is calling on the U.S. Centers for Disease Control and prevention to answer questions following up on a conversation between FOX5NY anchor Teresa Priolo and CDC Chief of Epidemiology and Surveillance Activity of The Bacterial Diseases Br...


Monday 11 July 2016

Lyme Disease guidelines.

Authors: Bailey J PMID: 27402647 [PubMed - in process] (Source: cmaj)

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Monday 11 July 2016

Don't be 'ticked' off by Lyme disease

The chief medical officer of Canada's Public Health Agency says cases of Lyme disease could be much higher than reported. @NightshiftMD talks about the symptoms of Lyme and what could be causing the increase in infections. (Source: CBC | Health)


Monday 11 July 2016

What's Really Inside Your Bug Spray?

It’s the height of summer — and if you’ve been spending more time outdoors lately, chances are you’ve got a few (or more) bug bites to show for your time in the sun. And while bites from pests are an inevitable part of summer, it’s important to reduce your risk of bug bites from mosquitoes and ticks. That’s because several species of these insects can carry dangerous disease, including Lyme disease and West Nile virus. “The most effective way to avoid West Nile virus disease is to prevent mosquito bites,” wrote the CDC in their summer health guidelines. “Repellents containing DEET, picaridin, IR3535, and some oil of lemon eucalyptus and para-menthane-diol products provide longer-lasting protection.” The consumer advocacy org...


Sunday 10 July 2016

Woman living with Lyme: Behind my smile I’m in constant pain

LIFE and business coach Janice Haddon describes how a debilitating disease has turned her life upside down. (Source: Daily Express - Health)


Friday 8 July 2016

Immunomodulatory effects of tick saliva on dermal cells exposed to Borrelia burgdorferi, the agent of Lyme disease

The prolonged feeding process of ixodid ticks, in combination with bacterial transmission, should lead to a robust inflammatory response at the blood-feeding site. Yet, factors present in tick saliva may down-... (Source: Parasites and Vectors)


Thursday 7 July 2016

Underreporting of Lyme and Other Tick‐Borne Diseases in Residents of a High‐Incidence County, Minnesota, 2009

Summary Lyme disease (LD), anaplasmosis, babesiosis and other tick‐borne diseases (TBDs) attributed to Ixodes ticks are thought to be widely underreported in the United States. To identify TBD cases diagnosed in 2009, but not reported to the Minnesota Department of Health (MDH), diagnostic and procedural billing codes suggestive of tick‐borne diseases were used to select medical charts for retrospective review in medical facilities serving residents of a highly endemic county in Minnesota. Of 444 illness events, 352 (79%) were not reported. Of these, 102 (29%) met confirmed or probable surveillance case criteria, including 91 (26%) confirmed LD cases with physician‐diagnosed erythema migrans (EM). For each confirmed and probable LD, probable anaplasmosis and confirmed babesiosis case...


Thursday 7 July 2016

Underreporting of Lyme and Other Tick ‐Borne Diseases in Residents of a High‐Incidence County, Minnesota, 2009

Summary Lyme disease (LD), anaplasmosis, babesiosis and other tick‐borne diseases (TBDs) attributed to Ixodes ticks are thought to be widely underreported in the United States. To identify TBD cases diagnosed in 2009, but not reported to the Minnesota Department of Health (MDH), diagnostic and procedural billing codes suggestive of tick‐borne diseases were used to select medical charts for retrospective review in medical facilities serving residents of a highly endemic county in Minnesota. Of 444 illness events, 352 (79%) were not reported. Of these, 102 (29%) met confirmed or probable surveillance case criteria, including 91 (26%) confirmed LD cases with physician‐diagnosed erythema migrans (EM). For each confirmed and probable LD, probable anaplasmosis and confirmed babesiosis case...


Wednesday 6 July 2016

Is Localized Scleroderma Caused by Borrelia burgdorferi?

Vector-Borne and Zoonotic Diseases , Vol. 0, No. 0. (Source: Vector-Borne and Zoonotic Diseases)

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Wednesday 6 July 2016

Incidence and antibiotic treatment of erythema migrans in Norway 2005–2009

Publication date: Available online 30 June 2016 Source:Ticks and Tick-borne Diseases Author(s): Knut Eirik Eliassen, Dag Berild, Harald Reiso, Nils Grude, Karen Sofie Christophersen, Cecilie Finckenhagen, Morten Lindbæk The first stage of Lyme borreliosis (LB) is mainly the typical skin lesion, erythema migrans (EM), which is estimated to comprise 80–90% of all LB cases. However, the reporting of and actual incidence of LB varies throughout Europe. Studies from Sweden and Holland found EM incidences varied from 53–464 EM/100,000 inhabitants/year. Under-reporting of LB is common and a coefficient of three to reach a realistic estimate is suggested. In Norway, it is mandatory to report only the second and third LB stages to the National Institute of Public Health. To find the N...


Wednesday 6 July 2016

5-hydroxytryptamine and Lyme disease. Opportunity for a novel therapy to reduce the cerebellar tremor?

Authors: Maximov GK, Maximov KG, Chokoeva AA, Lotti T, Wollina U, Patterson JW, Guarneri C, Tana C, Fioranelli M, Roccia MG, Kanazawa N, Tchernev G Abstract Lyme boreliosis is caused by the spirochete Borrelia burdorferi, which is transmitted by ticks. A 59 year-old woman developed pyrexia, strong headaches, ataxia, dysarthria and tremor of the limbs after a tick bite. She was unable to work and eat on her own. She was hospitalized three times and diagnosed with cerebellar intention tremor, cerebellar ataxia, dysarthria, bilateral horizontal gaze paralysis and a central lesion of the left facial nerve. There were no pyramidal, sensory or psychiatric disturbances. The brain MRI showed multifocal leucoencephalopathy with many hyperintense areas in both hemispheres, as well as in the ...


Tuesday 5 July 2016

Human Granulocytic Anaplasmosis and Lyme Disease

To the Editor Human granulocytic anaplasmosis (HGA), caused by the rickettsia Anaplasma phagocytophilum, is vectored by the same Ixodes spp ticks that transmit Lyme disease. HGA is associated with fever, headache, cytopenia, and rarely mortality (if the infection occurs in elderly or immunocompromised hosts). HGA is not spread person-to-person by mucocutaneous exposure to the blood of infected patients; does not typically, or perhaps ever, cause bleeding from multiple body sites; is not usually associated with diarrhea; and has never been associated with relative bradycardia. Convalescent phase antibody titers to the etiologic agent reach 640 or greater in more than 90% of culture-confirmed cases in the United States, and morulae are detected on blood smears in more than 70% of such cases....


Sunday 3 July 2016

Efficacy of Antibiotic Prophylaxis for the Prevention of Lyme Disease After Tick Bite

Lyme disease is endemic in several areas in the United States, including the Northeast and mid-Atlantic states, upper mid-West, and the West Coast. It is caused by Borrelia burgdorferi and is transmitted to humans by ticks of the Ixodes species. The question of how to manage patients who have experienced a tick bite arises frequently in clinical practice and includes whether or not to recommend antibiotics either as a single dose or longer course in an effort to prevent development of acute Lyme disease characterized by systemic symptoms and the rash of erythema migrans. (Source: The American Journal of Medicine)


Friday 1 July 2016

Seroprevalence of West Nile virus, Crimean-Congo hemorrhagic fever virus, Francisella tularensis and Borrelia burgdorferi in rural population of Manisa, western Turkey.

CONCLUSION: Seropositivity rates were not found to be higher than the expected rates. Further, studies are needed to evaluate the threat of vector borne zoonoses and associated risk factors in the study area. PMID: 27353580 [PubMed - in process] (Source: Journal of Vector Borne Diseases)


Friday 1 July 2016

Lyme Myocarditis Presenting as Chest Pain in an Adolescent Girl

Abstract: A previously healthy adolescent girl presented to the emergency department with new onset chest and right upper quadrant abdominal pain. Laboratory studies and imaging were consistent with myocarditis. She developed heart block after admission and required stabilization in the cardiac intensive care unit. Lyme serology returned positive, and her condition was diagnosed as Lyme disease-associated myocarditis. (Source: Pediatric Emergency Care)


Thursday 30 June 2016

Erratum to: Bilateral vestibular hypofunction and Lyme disease: a causal link?

(Source: Acta Neurologica Belgica)


Thursday 30 June 2016

Lyme Disease

Abstract Lyme disease is caused by the spirochetal bacteria Borrelia burgdorferi and transmitted by ticks in the genus Ixodes. The key reservoirs for the spirochete include rodents and birds, and the primary hosts for ticks include rodents, birds, and lizards for immature stages and large mammal for the adults. Since its recognition in the USA in the 1970s, it has continued to emerge, increasing both in case numbers and geographic distribution. In the last two decades, a number of new findings have been observed, including a vast increase in disease distribution, additional Borrelia species causing disease in humans, and newly recognized clinical presentations of the disease. Areas of greatest need include (1) new diagnostic tests, including tests that detect Borrelia DNA, antigen...


Thursday 30 June 2016

Spirochetes flagellar collar proteins have astounding effects in orientation of periplasmic flagella, bacterial shape, motility, and stability of motors in Borrelia burgdorferi

This article is protected by copyright. All rights reserved. (Source: Molecular Microbiology)

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Thursday 30 June 2016

Potential flaws in test for Lyme Disease

A new microscopy technique (LM-method) developed to detect Lyme disease is unable to distinguish infected patients from healthy controls, yielding false-positive results that could lead doctors to over-diagnose a patient, according to new research. (Source: ScienceDaily Headlines)

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Wednesday 29 June 2016

First Evidence of an Established Population of Ixodes scapularis (Acari: Ixodidae) in South Dakota

Ixodes scapularis Say (Acari: Ixodidae) is the most important vector of human disease in the United States. Recent efforts by public health officials to determine its presence on a county-by-county basis have been undertaken to assist in Lyme disease risk assessment. Recent modeling efforts show that South Dakota can potentially support populations of I. scapularis based on favorable climatic conditions and presence of suitable hosts to support tick populations within the state. We provide the first documentation of an established population of I. scapularis in Clay County, SD, providing only the third record of the presence of this tick species within the state. (Source: Journal of Medical Entomology)


Wednesday 29 June 2016

Mayo Clinic Minute: On the Trail With Tick Researchers

The most common tick-borne sickness in the U.S. is Lyme disease, but there are other lesser-known illnesses that also can be transmitted by a tick bite. And, although they are sometimes overlooked, the Centers for Disease Control and Prevention says these tick-borne diseases pose an increasing threat to public health. That's why researchers routinely head into the woods to learn more about ticks. Knowing [...] (Source: News from Mayo Clinic)


Wednesday 29 June 2016

Prevalence of Tick-Borne Pathogens in Host-Seeking Amblyomma americanum (Acari: Ixodidae) and Odocoileus virginianus (Artiodactyla: Cervidae) in Florida

Amblyomma americanum (L.), the lone star tick, is an aggressive tick that is expanding its geographic range within the United States. This tick is the vector for the human and veterinary pathogens Ehrlichia chaffeensis and Ehrlichia ewingii and is associated with other microbes of unspecified pathogenicity including Rickettsia amblyommii, Panola Mountain Ehrlichia, and Borrelia lonestari. In Florida, there has been sparse contemporary data on the prevalence of these organisms in host-seeking lone star ticks. To determine the prevalence of this tick and associated microbes in North Central Florida state parks, ~1,500 lone star tick specimens were collected between 2010 and 2012 analyzed by polymerase chain reaction (PCR) sequencing. Additionally, 393 white-tailed deer, Odocoileus virginianu...


Tuesday 28 June 2016

CCL19 as a Chemokine Risk Factor for Post-Treatment Lyme Disease Syndrome: A Prospective Clinical Cohort Study.

The objective of this study is to investigate associations between PTLDS and immune mediator levels during acute illness and at several time points following treatment. Seventy-six participants with physician-documented erythema migrans and 26 healthy controls with no history of Lyme disease were enrolled. Sixty-four cytokines, chemokines, and inflammatory markers were measured at each visit for a total of 6 visits over 1 year. An operationalized definition of PTLDS incorporating symptoms and functional impact was applied at 6 months and 1 year following treatment completion, and clinical outcome groups were defined as Return to Health, Symptoms Only, and PTLDS. Significance analysis of microarrays identified 7 of the 64 immune mediators as differentially regulated by group. Generalized lo...


Tuesday 28 June 2016

Borrelia burgdorferi sensu lato in Ixodes neuquenensis and Ixodes sigelos ticks from the Patagonian region of Argentina.

This study was conducted to detect Borrelia burgdorferi sensu lato infection in ixodid ticks from the Patagonia region in the south of Argentina. Therefore, ticks were collected on rodents in the provinces of Chubut, Río Negro and Santa Cruz. These ticks were identified as nymphs of Ixodes neuquenensis and Ixodes sigelos. The B. burgdorferi s.l. infection was tested by a battery of PCR methods targeting the gene flagellin (fla) and the rrfA-rrlB intergenic spacer region (IGS). Three pools of I. sigelos nymphs from Chubut and Santa Cruz provinces as well as one pool of I. neuquenensis nymphs from Río Negro province were tested positive in the fla-PCR. The samples of I. sigelos were also positive for the IGS-PCR. Phylogenetically, the haplotypes found in the positive ticks belong to the B....


Tuesday 28 June 2016

Cross-Species Interferon Signaling Boosts Microbicidal Activity within the Tick Vector.

Authors: Smith AA, Navasa N, Yang X, Wilder CN, Buyuktanir O, Marques A, Anguita J, Pal U Abstract Evolution of hematophagy in blood-sucking parasites likely involves communication with their hosts. We find that Ixodes ticks are responsive to IFNγ acquired in a blood meal from mice infected with the Lyme disease-causing bacteria Borrelia burgdorferi, leading to induction of antimicrobial responses. Ixodes ticks parasitizing B. burgdorferi-infected mice upregulated an I. scapularis Rho-like GTPase (IGTPase). IGTPase knockdown enhanced B. burgdorferi levels in post-fed ticks, suggesting this protein controls spirochete survival. Notably, IGTPase was only induced during pathogen acquisition from mice and not upon transmission to naive hosts. Microinjection of ticks with IFNγ indu...

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Friday 24 June 2016

Shadick Receives Award of Recognition for Lyme Disease Prevention

Nancy Shadick, MD, MPH, director of the Lyme Disease Prevention Center in the Division of Rheumatology, Immunology and Allergy, recently received an Award of Recognition in the area of Lyme disease prevention and education at MIT’s Lyme Innovation Ha (Source: BWH News)


Friday 24 June 2016

Borrelia sp. phylogenetically different from Lyme disease- and relapsing fever-related Borrelia spp. in Amblyomma varanense from Python reticulatus

Species of the genus Borrelia are causative agents of Lyme disease and relapsing fever. Lyme disease is the most commonly reported vector-borne disease in the northern hemisphere. However, in some parts of the wo... (Source: Parasites and Vectors)


Thursday 23 June 2016

Next‐Generation Sequencing Reveals Restriction and Clonotypic Expansion of Treg Cells in Juvenile Idiopathic Arthritis

ConclusionWe identified restriction and clonotypic expansions in the JIA Treg cell repertoire with sharing of Treg cell clonotypes across patients. These findings suggest that abnormalities in the Treg cell repertoire, possibly engendered by shared antigenic triggers, may contribute to disease pathogenesis in JIA. (Source: Arthritis and Rheumatism)


Thursday 23 June 2016

A method to distinguish morphologically similar Peromyscus species using extracellular RNA and high-resolution melt analysis.

Authors: Nelson VA, Clarke BL, Crossland JP, Bemis LT Abstract A method applying high-resolution melt (HRM) analysis to PCR products copied and amplified from extracellular RNA (exRNA) has been developed to distinguish two morphologically similar Peromyscus species: P. leucopus and P. maniculatus. P. leucopus is considered the primary reservoir host of Borrelia burgdorferi, the causative agent for Lyme disease in North America. In northern Minnesota the habitat ranges of P. leucopus overlaps with that of P. maniculatus. Serum samples from live mice of both species were collected from cheek bleeds, total extracellular RNA (exRNA) was extracted, copied using reverse transcription and amplified by PCR followed by HRM analysis. A circulating ribosomal RNA (rRNA) was identified which di...


Thursday 23 June 2016

Next ‐Generation Sequencing Reveals Restriction and Clonotypic Expansion of Treg Cells in Juvenile Idiopathic Arthritis

ConclusionWe identified restriction and clonotypic expansions in the JIA Treg cell repertoire with sharing of Treg cell clonotypes across patients. These findings suggest that abnormalities in the Treg cell repertoire, possibly engendered by shared antigenic triggers, may contribute to disease pathogenesis in JIA. (Source: Arthritis and Rheumatism)



Wednesday 22 June 2016

Pre-exposure Prophylaxis With OspA-Specific Human Monoclonal Antibodies Protects Mice Against Tick Transmission of Lyme Disease Spirochetes

Conclusions. Our study indicates that OspA-specific HuMabs can prevent the transmission of Borrelia and that administration of these antibodies could be employed as preexposure prophylaxis for Lyme disease. (Source: The Journal of Infectious Diseases)


Wednesday 22 June 2016

Effectiveness of Residential Acaricides to Prevent Lyme and Other Tick-borne Diseases in Humans

Conclusions. Used as recommended, acaricide barrier sprays do not significantly reduce the household risk of tick exposure or incidence of tick-borne disease. Measures for preventing tick-borne diseases should be evaluated against human outcomes to confirm effectiveness. (Source: The Journal of Infectious Diseases)

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Tuesday 21 June 2016

Insights into Borrelia miyamotoi infection from an untreated case demonstrating relapsing fever, monocytosis and a positive C6 Lyme serology

We describe a patient from the United States with PCR- and serology-confirmed Borrelia miyamotoi infection who recovered without antibiotics. Our findings suggest that B. miyamotoi infection may cause relapsing fever, blood monocytosis and antibody reactivity to the C6 peptide. Further studies are required to better define the spectrum of clinical and laboratory findings for this emerging tick-transmitted infection. (Source: Diagnostic Microbiology and Infectious Disease)


Tuesday 21 June 2016

Research Roundup

Study in elderly identifies predictors of remission of depression Meta‐analysis finds omega‐3s effective as adjunctive treatment for depression Citalopram shows effectiveness for range of Alzheimer's disease symptoms Metoclopramide controls hypersalivation associated with clozapine treatment Augmentation therapy with memantine improves symptoms of schizophrenia Cognitive symptoms in Lyme disease fail to respond to antibiotics Psychoactive drug use adds dimension to Islamic terrorist activity (Source: The Brown University Psychopharmacology Update)


Tuesday 21 June 2016

Live Attenuated Borrelia burgdorferi Targeted Mutants in an Infectious Strain Background Protect Mice from Challenge Infection.

Authors: Hahn BL, Padmore LJ, Ristow LC, Curtis MW, Coburn J Abstract Borrelia burgdorferi, B. garinii and B. afzelii are all agents of Lyme disease in different geographic locations. If left untreated, Lyme disease can cause significant and long-term morbidity, which may continue after appropriate antibiotic therapy has been administered and live bacteria are no longer detectable. The increasing incidence and geographic spread of Lyme disease is renewing interest in vaccination of at-risk populations. We took the approach of vaccinating mice with two targeted mutant strains of B. burgdorferi that, unlike the parental strain, are avirulent in mice. Mice vaccinated with both strains were protected against challenge by the parental strain and a heterologous B. burgdorferi strain by e...


Tuesday 21 June 2016

No serological evidence for Borrelia burgdorferi sensu lato infection in patients with dilated cardiomyopathy in Northern France

10.1080/23744235.2016.1193790Yohan N’Guyen (Source: Infectious Diseases)

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Tuesday 21 June 2016

Insights into Borrelia Miyamotoi Infection from an Untreated Case Demonstrating Relapsing Fever, Monocytosis and a Positive C6 Lyme Serology

We describe a patient from the United States with PCR- and serology-confirmed Borrelia miyamotoi infection who recovered without antibiotics. Our findings suggest that B. miyamotoi infection may cause relapsing fever, blood monocytosis and antibody reactivity to the C6 peptide. Further studies are required to better define the spectrum of clinical and laboratory findings for this emerging tick-transmitted infection. (Source: Diagnostic Microbiology and Infectious Disease)


Tuesday 21 June 2016

Decision Support in Medicine: Lyme Disease

1. Are you sure your patient has Lyme disease? What are the typical findings for this disease? The most common manifestation is the rash, termed erythema migrans (early localized Lyme... (Source: Pediatric News)

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Sunday 19 June 2016

Fluorescent membrane markers elucidate the association of Borrelia burgdorferi with tick cell lines.

This study aimed to describe the association of Borrelia burgdorferi s.s. with ixodid tick cell lines by flow cytometry and fluorescence and confocal microscopy. Spirochetes were stained with a fluorescent membrane marker (PKH67 or PKH26), inoculated into 8 different tick cell lines and incubated at 30°C for 24 h. PKH efficiently stained B. burgdorferi without affecting bacterial viability or motility. Among the tick cell lines tested, the Rhipicephalus appendiculatus cell line RA243 achieved the highest percentage of association/internalization, with both high (90%) and low (10%) concentrations of BSK-H medium in tick cell culture medium. Treatment with cytochalasin D dramatically reduced the average percentage of cells with internalized spirochetes, which passed through a dramatic morph...


Saturday 18 June 2016

The Borrelia burgdorferi telomere resolvase, ResT, anneals ssDNA complexed with its cognate ssDNA-binding protein

We report here that ResT promotes single-strand annealing of both free DNA strands and ssDNA complexed with single-stranded DNA binding protein (SSB). The annealing of complementary strands bound by SSB requires a ResT–SSB interaction that is mediated by the conserved amphipathic C-terminal tail of SSB. These properties of ResT are similar to those demonstrated for the recombination mediator protein, RecO, of the RecF pathway. Borrelia burgdorferi is unusual in lacking identifiable homologs of the RecFOR proteins. We propose that ResT may provide missing RecFOR functions. (Source: Nucleic Acids Research)


Friday 17 June 2016

Most Popular NEJM Group Feature This Week: Lyme Disease "Hackathon" (FREE)

By the Editors Here's the most clicked-on item we featured from NEJM Group … (Source: Physician's First Watch current issue)


Thursday 16 June 2016

UPMC unveils Center for Care of Infectious Diseases

UPMC will cut the ribbon Thursday on its $3 million Center for Care of Infectious Diseases, which houses several existing services in a shared, renovated space. The center includes 12 exam rooms and the tools to evaluate patients with potentially contagious airborne diseases. Health care specialists will work with patients on a range of infectious diseases, including HIV and AIDS, bloodstream infections, Lyme disease and even Zika, according to a representative for UPMC. UPMC invested $4.1 million… (Source: bizjournals.com Health Care:Pharmaceuticals headlines)


Wednesday 15 June 2016

Role of phrenic nerve in respiratory distress secondary to Lyme neuroborreliosis

Conclusion This paper reviews the literature pertaining to the importance of the phrenic nerve in Lyme disease. (Source: Polish Annals of Medicine)


Wednesday 15 June 2016

Insect Repellents

Date:  July 4, 2016 Issue #:  1498 Summary:  Use of insect repellents is strongly recommended by the CDC and the EPA to prevent Zika virus infection and other mosquito- and tickborne diseases. Mosquitoes can transmit chikungunya, dengue, West Nile, and yellow fever viruses, and malaria. Ticks can transmit Lyme disease and rickettsial diseases such as Rocky Mountain spotted fever. (Source: The Medical Letter)

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Wednesday 15 June 2016

Current Guidelines, Common Clinical Pitfalls, and Future Directions for Laboratory Diagnosis of Lyme Disease, United States

A. Moore et al. (Source: Emerging Infectious Diseases Journal)


Tuesday 14 June 2016

Treatment of Lyme Disease

This Medical Letter review summarizes antibiotic regimens to treat the dermatological, neurological, cardiac, and rheumatological manifestations of Lyme disease. (Source: JAMA)


Sunday 12 June 2016

Acute isolated partial oculomotor nerve palsy due to Lyme neuroborreliosis in a 5 year old girl.

Authors: Drenckhahn A, Spors B, Knierim E Abstract Lyme neuroborreliosis is a frequent cause of facial nerve palsy in children, isolated oculomotor nerve palsy due to Borrelia-associated nervous system infection however is rarely seen. Here we report a case of isolated oculomotor nerve palsy due to a nervous system infection with Borrelia burgdorferi in childhood and restitutio in integrum after intravenous antibiotic therapy. PMID: 27323659 [PubMed - as supplied by publisher] (Source: European Journal of Paediatric Neurology)


Sunday 12 June 2016

From the Blogs: What's Wrong with Guidelines?; Healthcare "Hackathon" on Lyme; Deciphering Your Benefits Package (FREE)

By the Editors Edited by Susan Sadoughi, MD, and André Sofair, MD, MPH Here's what's happening on the NEJM Journal Watch blogs right now: Clinical Conversations: What's wrong with … (Source: Physician's First Watch current issue)


Sunday 12 June 2016

Seroprevalence of Borrelia burgdorferi antibodies in white-tailed deer from texas

Publication date: Available online 13 June 2016 Source:International Journal for Parasitology: Parasites and Wildlife Author(s): Shakirat A. Adetunji, Rosina C. Krecek, Gabrielle Castellanos, John C. Morrill, Alice Blue-McLendon, Walt E. Cook, Maria D. Esteve-Gassent Lyme Disease is caused by the bacterial pathogen Borrelia burgdorferi, and is transmitted by the tick-vector Ixodes scapularis. It is the most prevalent arthropod-borne disease in the United States. To determine the seroprevalence of B. burgdorferi antibodies in white-tailed deer (Odocoileus virginianus) from Texas, we analyzed serum samples (n = 1493) collected during the 2001–2015 hunting seasons, using indirect ELISA. Samples with higher sero-reactivity (0.803 and above) than the negative control group (0.662) ...


Friday 10 June 2016

Comparing the effect of a leaflet and a movie in preventing tick bites and Lyme disease in The Netherlands

Lyme disease (LD) has become the most common vector borne illness in the Northern hemisphere. Prevention relies predominantly on fostering protective behaviors (e.g., avoiding tick areas, using protective clot... (Source: BMC Public Health)

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Thursday 9 June 2016

Stop Lyme disease - How one woman was cured

(NaturalNews) More than 300,000 people are diagnosed with Lyme disease in the United States - each year. Sadly, many more suffer from this disease but get misdiagnosed with fibromyalgia, multiple sclerosis, chronic fatigue syndrome or any number of the so-called 'psychiatric' conditions... (Source: NaturalNews.com)


Wednesday 8 June 2016

Global Tn‐seq Analysis of Carbohydrate Utilization and Vertebrate Infectivity of Borrelia burgdorferi

This article is protected by copyright. All rights reserved. Abbreviated Summary This work establishes Tn‐seq as a new tool for performing high‐throughput genetic fitness analyses in Borrelia burgdorferi. We used the technique to perform an in vitro screen exploring mechanisms of mannose, maltose, trehalose, and N‐acetyl‐glucosamine metabolism in B. burgdorferi as well as a complementing in vivo screen in mice. In doing so we obtained insight into the potential functions of genes annotated as encoding carbohydrate transporters and an additional function of the response regulator Rrp1. (Source: Molecular Microbiology)


Tuesday 7 June 2016

Trilobites: Fighting Lyme Disease in the Genes of Nantucket’s Mice

Residents there heard a proposal Monday from a M.I.T. scientist to use genetically engineered mice to stop the spread of the tick-borne disease. (Source: NYT Health)

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Monday 6 June 2016

Bilateral vestibular hypofunction and Lyme disease: a causal link?

(Source: Acta Neurologica Belgica)


Monday 6 June 2016

Combination therapy cures tick-borne illness in mice

A novel combination therapy cures an emerging infectious disease, babesiosis, which is transmitted by the same ticks that transmit the agents of Lyme disease, report researchers. This 'radical' therapy not only clears the infection but also prevents the recurrence that often occurs with existing treatments. (Source: ScienceDaily Headlines)



Monday 6 June 2016

Combination therapy cures tick-borne illness in mice

(Yale University) A novel combination therapy cures an emerging infectious disease, babesiosis, which is transmitted by the same ticks that transmit the agents of Lyme disease, said Yale researchers. This 'radical' therapy not only clears the infection but also prevents the recurrence that often occurs with existing treatments. (Source: EurekAlert! - Infectious and Emerging Diseases)


Friday 3 June 2016

Institute for Systems Biology receives another $3M to study chronic Lyme disease

The Institute for Systems Biology’s Lyme disease project has received $3 million to continue its work on the chronic disease. On top of the funding received when the project was initiated last year, ISB now has a total of $6.1 million from Jeff and Liesl Wilke, Jeff and MacKenzie Bezos, the Bay Area Lyme Foundation and the Steven & Alexandra Cohen Foundation. Lyme disease is caused by bacteria transmitted to humans through a tick bite and is often misdiagnosed because people don’t know they… (Source: bizjournals.com Health Care:Biotechnology headlines)

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Thursday 2 June 2016

Well: Think Like a Doctor: The Tired Gardener

What is wrong with a lively 67-year-old gardener who develops a daily fever and shaking chills along with chest pain and a dry cough? (Source: NYT)


Thursday 2 June 2016

Lyme disease.

Authors: Schned ES, Williams DN PMID: 27237181 [PubMed] (Source: Postgraduate Medicine)


Wednesday 1 June 2016

Palisaded neutrophilic and granulomatous dermatitis - cutaneous manifestation of Lyme disease or connected with CTD? Case report.

CONCLUSIONS: Clinical diagnosis of PNGD is difficult, and is based mainly on the histopathological picture. Systemic therapy is incorporated mainly due to the systemic disease. The patient requires further observation in the direction of associated systemic disorders. PMID: 27294654 [PubMed - in process] (Source: Annals of Agricultural and Environmental Medicine : AAEM)

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Wednesday 1 June 2016

Synthesis of Th17 cytokines in the culture of peripheral blood mononuclear cells stimulated with Borrelia burgdorferi sensu lato.

CONCLUSIONS: IL-17A, IL-17F and IL-22 are synthesized simultaneously by PBMC stimulated with B. burgdorferi. There is no antagonism between Th17 response and IL-10 expression. The role of Th17 cytokines seems to differ depending on the clinical stage of Lyme borreliosis and on the B. burgdorferi species. PMID: 27294626 [PubMed - in process] (Source: Annals of Agricultural and Environmental Medicine : AAEM)


Wednesday 1 June 2016

Symptomatic co-infection with Babesia microti and Borrelia burgdorferi in patient after international exposure; a challenging case in Poland.

Authors: Jabłońska J, Żarnowska-Prymek H, Stańczak J, Kozłowska J, Wiercińska-Drapało A Abstract The report presents a well-documented case of symptomatic co-infection of Babesia microti and Borrelia burgdorferi in a Polish immunocompetent patient after travelling to Canada and the USA. PMID: 27294655 [PubMed - in process] (Source: Annals of Agricultural and Environmental Medicine : AAEM)


Wednesday 1 June 2016

Addendum: Doxycycline for Young Children?

Date:  June 20, 2016 Issue #:  1497 Summary:  A reader commenting on our Treatment of Lyme Disease article (Med Lett Drugs Ther 2016; 58:57) objected to a footnote in the table advising against use of doxycycline in children <8 years old. This warning has been included in the labeling of all tetracyclines since 1970 when it was recognized, after decades of use, that these drugs caused permanent staining and enamel hypoplasia of developing teeth. The CDC recently stated that short courses of doxycycline, which was first marketed in the US in 1967 and has less affnity for calcium than other tetracyclines, have not been shown to cause tooth staining.1 That statement was pr...


Wednesday 1 June 2016

Wilke Cohen Lyme Disease Project gets $3 million from the Steven & Alexandra Cohen Foundation

(Institute for Systems Biology) The Institute for Systems Biology has received a transformational, multi-year pledge from the Steven & Alexandra Cohen Foundation to support the Wilke Cohen Lyme Disease Project. In addition to an initial $3.1 million in funding from Jeff and Liesl Wilke, Jeff and MacKenzie Bezos, and the Bay Area Lyme Foundation, the commitments total $6.1 million in pledges and cash. ISB researchers have discovered potential biomarkers, including a set of proteins in the blood known to be important for bone marrow regeneration and stability. (Source: EurekAlert! - Biology)


Tuesday 31 May 2016

Invasion of tick-borne disease

Modelling the spatial spread of vector-borne zoonotic pathogens maintained in enzootic transmission cycles remains a major challenge. The best available spatio-temporal data on pathogen spread often take the form of human disease surveillance data. By applying a classic ecological approach—occupancy modelling—to an epidemiological question of disease spread, we used surveillance data to examine the latent ecological invasion of tick-borne pathogens. Over the last half-century, previously undescribed tick-borne pathogens including the agents of Lyme disease and human babesiosis have rapidly spread across the northeast United States. Despite their epidemiological importance, the mechanisms of tick-borne pathogen invasion and drivers underlying the distinct invasion trajectories o...


Tuesday 31 May 2016

Canine bicavitary carcinomatosis with transient needle tract metastasis diagnosed by multiplex immunocytochemistry

Abstract A 6‐year‐old, male castrated, mixed‐breed dog was referred to the James L. Voss Veterinary Teaching Hospital at Colorado State University for bicavitary effusion. On examination, the dog was tachycardic and tachypneic with bilaterally decreased lung sounds. Thoracic and abdominal ultrasonic examination revealed pleural and peritoneal effusions, which were aspirated and submitted for fluid analysis and cytology. Both cavity fluids were classified as exudates with a large population of vacuolated mononuclear cells. Multiplex immunocytochemistry (ICC) for cytokeratin and vimentin demonstrated exclusively cytokeratin expression, indicating these cells were of epithelial origin. A full diagnostic evaluation was performed, including CBC, clinical chemistry, a pet‐side test for h...


Tuesday 31 May 2016

A School-Based Intervention to Increase Lyme Disease Preventive Measures Among Elementary School-Aged Children

Vector-Borne and Zoonotic Diseases , Vol. 0, No. 0. (Source: Vector-Borne and Zoonotic Diseases)


Tuesday 31 May 2016

Beyond the bull's eye: Recognizing Lyme disease.

Authors: Chaaya G, Jaller-Char JJ, Ali SK Abstract A rash occurs in 80% of Lyme disease cases, but only about a third of the rashes develop into a classic bull's-eye lesion. Here's what to look for and how best to treat. PMID: 27474818 [PubMed - as supplied by publisher] (Source: The Journal of Family Practice)

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Tuesday 31 May 2016

Toll-like receptor cascade and gene polymorphism in host–pathogen interaction in Lyme disease

(Source: Journal of Inflammation Research)


Monday 30 May 2016

Stress level, parasite load, and movement pattern in a small-mammal reservoir host for Lyme disease

Canadian Journal of Zoology, e-First Articles. Occurrence of Lyme disease has increased rapidly in Canada in the past 5 years. The emergence of Lyme disease coincides with the range expansion of the primary host, the white-footed mouse (Peromyscus leucopus (Rafinesque, 1818)), in the region. We evaluated the effects of stress level, parasite load, and forest-patch characteristics on P. leucopus movement pattern. We found negative relations between on the one hand the adrenal gland size, a proxy for stress level, and population density, and on the other hand, home-range area and movement rate of mouse individuals, suggesting that stressed mice cannot maintain a large home range. Population density was also related with excursion (outside the forest patch) and exploration (outside the home r...


Monday 30 May 2016

Prospective study on the chemokine CXCL13 in neuroborreliosis and other aseptic neuroinfections

The study evaluates the clinical significance of CXCL13 (leukocyte chemoattractant synthesized in CSF ) in Lyme neuroborreliosis (LNB) and other aseptic CNS infections.244 patients with symptoms of neuroinfection and/or LNB were divided into groups: A - patients with LNB-positive antibodies in serum and CSF (96) or CSF only (14); B - patients with aseptic non-borrelial neuroinfections (82); C-negative controls (52). Group A was divided into A1-A4 according to pleocytosis in CSF and AIIgG positivity. (Source: Journal of the Neurological Sciences)


Monday 30 May 2016

Facial expressions are key to first impressions. What does that mean for people with facial paralysis?

This article was originally published on The Conversation. Read the original article. -- This feed and its contents are the property of The Huffington Post, and use is subject to our terms. It may be used for personal consumption, but may not be distributed on a website. (Source: Science - The Huffington Post)


Sunday 29 May 2016

Long-term Follow-up of Patients With Lyme Disease: Longitudinal Analysis of Clinical and Quality-of-life Measures

Conclusions. Comorbid conditions can play a role in the reporting of long-term symptoms and overall QOL of Lyme disease patients and should be considered in the evaluation of these patients. Clinical Trials Registration. NCT00028080. (Source: Clinical Infectious Diseases)


Saturday 28 May 2016

First Case of Lyme Arthritis Documented in Prosthetic Knee

(MedPage Today) -- Symptoms started 10 months after joint arthroplasty (Source: MedPage Today Geriatrics)


Friday 27 May 2016

Insect Resilience and Climate Change

Ecosystem tipping points and climate change warning signs are making headlines. Yesterday I read record breaking heat is melting roads in some of India's busiest cities. Scientists predicted a rise in temperature would lead to an increase in the number of insects worldwide, ushering dire consequences to the farming community. Warnings unheeded to our own detriment as now one of Africa's staple crops, cassava, is reeling from super bug infestation. In short climate change has already altered earth's ecological footprint with unstable fluctuating seasons. A longer season means insects have a higher metabolic rate, quicker gestation and more frequent reproduction. According to an EPA report titled Lyme Disease - Climate Change Indicators In the US stated "Between 1991 and 2013 lyme dise...

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Friday 27 May 2016

A Guide to Safety on the Appalachian Trail

“You would think it would be things like wildlife, raging rivers and stuff like that,” an official says. But you should worry about little things like ticks. (Source: NYT Health)


Friday 27 May 2016

Prevalence of the Lyme Disease Spirochete, Borrelia burgdorferi, in Blacklegged Ticks, Ixodes scapularis at Hamilton-Wentworth, Ontario.

This study explores the presence of B. burgdorferi s.l. in blacklegged ticks, Ixodes scapularis, collected at Dundas, Ontario (a locality within the region of Hamilton-Wentworth). Using passive surveillance, veterinarians and pet groomers were asked to collect blacklegged ticks from dogs and cats with no history of travel. Additionally, I. scapularis specimens were submitted from local residents and collected by flagging. Overall, 12 (41%) of 29 blacklegged ticks were infected with B. burgdorferi s.l. Using polymerase chain reaction (PCR) and DNA sequencing, two borrelial amplicons were characterized as B. burgdorferi sensu stricto (s.s.), a genospecies pathogenic to humans and certain domestic animals. Notably, three different vertebrate hosts each had two engorged I. scapularis females r...


Thursday 26 May 2016

DNA‐based identification and OspC serotyping in cultures of Borrelia burgdorferi s.l. isolated from ticks collected in the Moravia (Czech Republic)

ABSTRACT Two different genetic loci, flaB and ospC, were employed to assign genospecies and OspC phylogenetic type to 18 strains isolated from ticks collected in Pisárky, a suburban park in the city of Brno, Czech Republic. The RFLP analysis revealed three different genospecies (B. afzelii, B. garinii, and B. valaisiana). Three samples from the collection contained more than one genospecies. In the other 15 strains, nucleotide sequences of flaB and ospC were determined. The following phylogenetic analysis assigned 12 isolates to genospecies B. garinii and three to B. afzelii. These isolates were further subdivided into seven distinct ospC groups. The most related OspC types were G2, G4, and G5 (B. garinii) and A3 and A8 (B. afzelii). (Source: Journal of Vector Ecology)


Thursday 26 May 2016

DNA ‐based identification and OspC serotyping in cultures of Borrelia burgdorferi s.l. isolated from ticks collected in the Moravia (Czech Republic)

ABSTRACT Two different genetic loci, flaB and ospC, were employed to assign genospecies and OspC phylogenetic type to 18 strains isolated from ticks collected in Pisárky, a suburban park in the city of Brno, Czech Republic. The RFLP analysis revealed three different genospecies (B. afzelii, B. garinii, and B. valaisiana). Three samples from the collection contained more than one genospecies. In the other 15 strains, nucleotide sequences of flaB and ospC were determined. The following phylogenetic analysis assigned 12 isolates to genospecies B. garinii and three to B. afzelii. These isolates were further subdivided into seven distinct ospC groups. The most related OspC types were G2, G4, and G5 (B. garinii) and A3 and A8 (B. afzelii). (Source: Journal of Vector Ecology)

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Thursday 26 May 2016

'Phage' fishing yields new weapon against antibiotic resistance

Researchers were fishing for a new weapon against antibiotic resistance and found one floating in a Connecticut pond. A virus called a bacteriophage, found in Dodge Pond in East Lyme, attacks a common multi-drug resistant bacterial pathogen called Pseudomonas aeruginosa, which can lethally infect people with compromised immune systems. (Source: ScienceDaily Headlines)


Tuesday 24 May 2016

Detection of Borrelia burgdorferi sensu stricto in Amblyomma americanum ticks in the southeastern United States: the case of selective compatibility

Authors: Nataliia Rudenko, Maryna Golovchenko, Kerry Clark, James H Oliver & Libor Grubhoffer (Source: Emerging Microbes and Infections)


Tuesday 24 May 2016

Lyme and Other Tickborne Diseases in New Hampshire Lyme and Other Tickborne Diseases in New Hampshire

New Hampshire continues to have one of the highest rates of Lyme disease in the nation. The state's Division of Public Health Services provides advice on diagnosis and treatment. State Health Alerts (Source: Medscape Medical News Headlines)


Tuesday 24 May 2016

[Correspondence] Borrelia mayonii: prying open Pandora's box of spirochetes – Authors' reply

We thank John Scott for his comments regarding our recent Article1 describing the identification of a novel genospecies of Borrelia burgdorferi sensu lato (Borrelia mayonii) as a new cause of Lyme borreliosis among patients in the upper midwestern USA. We agree with Scott that multiple B burgdorferi sensu lato genospecies can infect human beings. Our wording “nearly all human infections are caused by three B burgdorferi sensu lato genospecies” reflects this, and does not exclude other B burgdorferi sensu lato genospecies. (Source: The Lancet Infectious Diseases)


Tuesday 24 May 2016

[Correspondence] Borrelia mayonii: prying open Pandora's box of spirochetes

Bobbi Pritt and colleagues1 reveal that Borrelia mayonii is a new member of the Borrelia burgdorferi sensu lato complex, and show that this spirochete is pathogenic to human beings. However, the authors err on several key points. They state B burgdorferi sensu stricto was previously the only cause of Lyme borreliosis in the USA. With the discovery of B mayonii, they take credit for describing the first non-B burgdorferi sensu stricto in patients in the USA; this assumption is not true. Girard and colleagues2 reported B bissettii in patients in California and Clark and colleagues3 documented B americana and B andersonii in human blood from residents in the southeastern USA. (Source: The Lancet Infectious Diseases)


Tuesday 24 May 2016

A Drug Combination Screen Identifies Drugs Active against Amoxicillin-Induced Round Bodies of In Vitro Borrelia burgdorferi Persisters from an FDA Drug Library

Jie Feng, Wanliang Shi, Shuo Zhang, David Sullivan, Paul G. Auwaerter, Ying Zhang (Source: Frontiers in Microbiology)


Monday 23 May 2016

Borrelia burgdorferi CheD Promotes Various Functions in Chemotaxis and the Pathogenic Life Cycle of the Spirochete [Molecular Pathogenesis]

Borrelia burgdorferi possesses a sophisticated chemotaxis signaling system; however, the roles of the majority of the chemotaxis proteins in the infectious life cycle have not yet been demonstrated. Specifically, the role of CheD during host colonization has not been demonstrated in any bacterium. Here, we systematically characterized the B. burgdorferi CheD homolog using genetics and biochemical and mouse-tick-mouse infection cycle studies. Bacillus subtilis CheD plays an important role in chemotaxis by deamidation of methyl-accepting chemotaxis protein receptors (MCPs) and by increasing the receptor kinase activity or enhancing CheC phosphatase activity, thereby regulating the levels of the CheY response regulator. Our biochemical analysis indicates that B. burgdorferi CheD significantly...

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Monday 23 May 2016

7 Ways to Give Ticks the Slip

Don't become the next meal for a disease-carrying parasite Source: HealthDay Related MedlinePlus Pages: Lyme Disease, Tick Bites (Source: MedlinePlus Health News)

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Monday 23 May 2016

Decrease in tick bite consultations and stabilization of early Lyme borreliosis in the Netherlands in 2014 after 15 years of continuous increase

Nationwide surveys have shown a threefold increase in general practitioner (GP) consultations for tick bites and early Lyme borreliosis from 1994 to 2009 in the Netherlands. We now report an update on 2014, wi... (Source: BMC Public Health)


Sunday 22 May 2016

Seroprevalence of Borrelia burgdorferi in Horses Presented for Coggins Testing in Southwest Virginia and Change in Positive Test Results Approximately 1 Year Later

ConclusionsHorses seropositive to B. burgdorferi are common in Virginia, and older horses are more likely to have a positive test result for OspF than younger horses. Follow‐up testing indicated that the majority of horses that were positive on initial testing did not have a different test result 5–17 months later. (Source: Journal of Veterinary Internal Medicine)


Saturday 21 May 2016

The Borrelia burgdorferi CheY3 Response Regulator is Essential for Chemotaxis and Completion of its Natural Infection Cycle

Summary Borrelia burgdorferi possesses a sophisticated and complex chemotaxis system but how the organism utilizes this system in its natural enzootic life cycle is poorly understood. Of the three CheY chemotaxis response regulators in B. burgdorferi, we found that only deletion of cheY3 resulted in an altered motility and significantly reduced chemotaxis phenotype. Though ΔcheY3 maintained normal densities in unfed ticks, their numbers were significantly reduced in fed ticks compared to the parental or cheY3‐complemented spirochetes. Importantly, mice fed upon by the ΔcheY3‐infected ticks did not develop a persistent infection. Intravital confocal microscopy analyses discovered that the ΔcheY3 spirochetes were motile, but appeared unable to reverse direction and perform the charact...


Saturday 21 May 2016

Cutaneous Small/Medium CD4+ Pleomorphic T-Cell Lymphoma–Like Nodule in a Patient With Erythema Chronicum Migrans

Abstract: CD4+ small/medium pleomorphic T-cell lymphoma is a relatively rare subtype of cutaneous lymphoproliferative disorder with an indolent clinical behavior. The place of this condition among lymphomas is debatable. The authors describe a rare case of the direct association of CD4 small/medium pleomorphic T-cell lymphoma–like solitary nodule with Borrelia burgdorferi infection in a 5-year-old boy, discuss the reactive nature of this condition, and emphasize the importance of clinicopathological correlation. (Source: The American Journal of Dermatopathology)


Saturday 21 May 2016

Young scientist behind new Lyme disease test

Graduate student Temple Douglas was just a high school intern when she began work on an experimental test that could be a "game-changer" (Source: Health News: CBSNews.com)


Saturday 21 May 2016

Experimental test could spot Lyme disease much faster

The young scientist who helped develop the test came up with the idea during her high school internship at a university lab (Source: Health News: CBSNews.com)


Thursday 19 May 2016

Habitat Suitability Model for the Distribution of Ixodes scapularis (Acari: Ixodidae) in Minnesota

Ixodes scapularis Say, the black-legged tick, is the primary vector in the eastern United States of several pathogens causing human diseases including Lyme disease, anaplasmosis, and babesiosis. Over the past two decades, I. scapularis-borne diseases have increased in incidence as well as geographic distribution. Lyme disease exists in two major foci in the United States, one encompassing northeastern states and the other in the Upper Midwest. Minnesota represents a state with an appreciable increase in counties reporting I. scapularis-borne illnesses, suggesting geographic expansion of vector populations in recent years. Recent tick distribution records support this assumption. Here, we used those records to create a fine resolution, subcounty-level distribution model for I. scapularis us...

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Thursday 19 May 2016

Differential associations of Borrelia species with European badgers (Meles meles) and raccoon dogs (Nyctereutes procyonoides) in western Poland

Publication date: Available online 20 May 2016 Source:Ticks and Tick-borne Diseases Author(s): Beata Wodecka, Jerzy Michalik, Robert S. Lane, Magdalena Nowak-Chmura, Anna Wierzbicka European badgers and raccoon dogs and their associated ticks and lice were assayed for the presence of Lyme borreliosis and relapsing fever-group spirochete DNA in western Poland. Analyses of blood, ear-biopsy and liver samples revealed that 25% of 28 raccoon dogs and 12% of 34 badgers were PCR positive for borreliae. Borrelia garinii was the dominant species in raccoon dogs (62.5%), followed by B. afzelii (25%) and B. valaisiana (12.5%). PCR-positive badgers were infected only with B. afzelii. A total of 351 attached ticks was recovered from 23 (82%) of the raccoon dogs and 13 (38%) of the badgers. Usin...


Thursday 19 May 2016

Lyme disease early-detection test is effective, study shows

After three years and 300 patients, researchers have proof that their early-detection urine test for Lyme disease works. In the case of Lyme disease, some patients may still have active cases but traditional tests don't register it, and these patients may not be receiving the additional round of treatment they need, authors say. (Source: ScienceDaily Headlines)


Thursday 19 May 2016

Pediatric Lyme Neuroborreliosis: Different clinical presentations of the same agent; Single center experience.

CONCLUSION: In this article, we report pediatric LNB patients, B. burgdorferi should also be considered in patients with atypical or severe neurologic involvement or a history of tick bite; it is known that the prognosis is good with appropriate and early treatment. PMID: 27179572 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)


Wednesday 18 May 2016

The joint synovium: A critical determinant of articular cartilage fate in inflammatory joint diseases

Publication date: Available online 19 May 2016 Source:Seminars in Cell & Developmental Biology Author(s): Pallavi Bhattaram, Unnikrishnan Chandrasekharan The synovium constitutes the envelope of articular joints and is a critical provider of synovial fluid components and articular cartilage nutrients. Its inflammation is a predominant feature and cause of joint degeneration in diseases as diverse as rheumatoid, psoriatic, juvenile and idiopathic arthritis, and lupus, gout and lyme disease. These inflammatory joint diseases (IJDs) are due to a wide variety of genetic, epigenetic and environmental factors that trigger, promote, and perpetuate joint destabilization. In spite of this variety of causes, IJDs share main pathological features, namely inflammation of the joint synovium...


Wednesday 18 May 2016

Randomized Trial of Longer-Term Therapy for Symptoms Attributed to Lyme Disease

This randomised trial has been highlighted by DynaMed as a practice changing update. It concludes that longer-term antibiotics for patients with persistent symptoms attributed to Lyme disease may not improve quality of life. (Source: Current Awareness Service for Health (CASH))


Wednesday 18 May 2016

Study shows GMU's Lyme disease early-detection test is effective

(George Mason University) After three years and 300 patients, George Mason University researchers have proof that their early-detection urine test for Lyme disease works. (Source: EurekAlert! - Infectious and Emerging Diseases)

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Tuesday 17 May 2016

Diapause in Ticks of the Medically Important Ixodes ricinus Species Complex

Publication date: Available online 17 May 2016 Source:Ticks and Tick-borne Diseases Author(s): Jeremy S. Gray, Olaf Kahl, Robert S. Lane, Michael L. Levin, Jean I. Tsao Four members of the Ixodes ricinus species complex, I. pacificus, I. persulcatus, I. ricinus and I. scapularis, have, between them, a worldwide distribution within the northern hemisphere. They are responsible for the transmission of several animal and human pathogens, including the causal agents of Lyme borreliosis, tick-borne encephalitis, human granulocytic anaplasmosis and human babesiosis. Despite the importance of these ticks as vectors, the knowledge and understanding of the role that diapause plays in their complex life cycles are confused and incomplete. In view of the continuing geographic spread of these t...

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Tuesday 17 May 2016

Mitogenomes reveal diversity of the European Lyme borreliosis vector Ixodes ricinus in Italy

Publication date: August 2016 Source:Molecular Phylogenetics and Evolution, Volume 101 Author(s): Giovanna Carpi, Andrew Kitchen, Hie Lim Kim, Aakrosh Ratan, Daniela I. Drautz-Moses, John J. McGraw, Maria Kazimirova, Annapaola Rizzoli, Stephan C. Schuster In Europe, the Ixodes ricinus tick is the most important vector of the etiological agents of Lyme borreliosis and several other emerging tick-borne diseases. Because tick-borne pathogens are dependent on their vectors for transmission, understanding the vector population structure is crucial to inform public health research of pathogen dynamics and spread. However, the population structure and dynamics of this important vector species are not well understood as most genetic studies utilize short mitochondrial and nuclear sequen...


Tuesday 17 May 2016

Lyme disease increases in Canada as climate, land use change

It's believed Canada has seen more confirmed cases of Lyme disease because of a combination of greater awareness, increased reporting and climate change. (Source: CBC | Health)


Tuesday 17 May 2016

Lyme disease increase alarms Canada's top doctor

An increase in Lyme disease cases is a concern for Canada's chief public health officer. (Source: CBC | Health)


Monday 16 May 2016

Pleomorphic forms of Borrelia burgdorferi induce distinct immune responses

Publication date: Available online 30 April 2016 Source:Microbes and Infection Author(s): Leena Meriläinen, Heini Brander, Anni Herranen, Armin Schwarzbach, Leona Gilbert Borrelia burgdorferi is the causative agent of tick-borne Lyme disease. As a response to environmental stress B. burgdorferi can change its morphology to a round body form. The role of B. burgdorferi pleomorphic forms in Lyme disease pathogenesis has long been debated and unclear. Here, we demonstrated that round bodies were processed differently in differentiated macrophages, consequently inducing distinct immune responses compared to spirochetes in vitro. Colocalization analysis indicated that the F-actin participates in internalization of both forms. However, round bodies end up less in macrophage lysosomes th...


Sunday 15 May 2016

Lyme disease patients hope conference fixes 'woefully inadequate' healthcare

Canadians living with Lyme disease say they hope a national conference in Ottawa helps fix the many issues they see with the way Canada diagnoses and treats the disease. (Source: CBC | Health)


Saturday 14 May 2016

Charity group wants Justin Trudeau to suck a lime for Lyme disease

A group of Manitobans has challenged Canada's prime minister to post a video of himself sucking on a lime — all in the name of charity. (Source: CBC | Health)


Thursday 12 May 2016

Children with swollen, painful knees: Is it Lyme disease or septic arthritis?

Septic or infectious arthritis of the knee and Lyme disease have similar symptoms in children but require different immediate treatment to ensure optimal recovery. A new study identifies four symptoms that are predictive of septic arthritis when the condition presents itself in a child's knee -- an important distinction in areas where Lyme disease is prevalent. (Source: ScienceDaily Headlines)

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Wednesday 11 May 2016

A case of reversible third-degree AV block due to Lyme carditis

The most common manifestation of Lyme carditis is a varying degree of atrioventricular (AV) conduction block. This case describes a 45-year-old male with third-degree AV block due to Lyme carditis. Treatment with intravenous antibiotics resulted in complete normalization of AV conduction, thereby averting permanent pacemaker implantation. (Source: Journal of Electrocardiology)


Wednesday 11 May 2016

Ceftriaxone-induced immune hemolytic anemia as a life-threatening complication of antibiotic treatment of ‘chronic Lyme disease’

10.1080/17843286.2016.1180829 < br/ > M. De Wilde (Source: Acta Clinica Belgica)


Wednesday 11 May 2016

A case of reversible third-degree AV block due to Lyme carditis

The most common manifestation of Lyme carditis is a varying degree of atrioventricular (AV) conduction block. This case describes a 45-year-old male with third degree AV block due to Lyme carditis. Treatment with intravenous antibiotics resulted in complete normalization of AV conduction, thereby averting permanent pacemaker implantation. (Source: Journal of Electrocardiology)


Tuesday 10 May 2016

New method to stop the spread of Lyme disease

Medication that is normally used to lower cholesterol could stop the spread of Lyme disease, according to a new study. Statins can reduce the burden in mice and can therefore be exploited to reduce the number of Lyme disease bacteria acquired by the feeding ticks. These investigators believe that this could be one of the many strategies to lower the incidence of Lyme disease by restricting bacterial survival at its source. (Source: ScienceDaily Headlines)


Tuesday 10 May 2016

Media Advisory: Integrated Tick Management Symposium

Annapolis, MD; May 10, 2016 – Tick-borne diseases such as Heartland virus, Lyme disease, and Rocky Mountain spotted fever are serious public-health threats. In order to address these threats, the U.S. Centers for Disease Control and Prevention, the Entomological Society of America, the IPM Institute of North America, and the North Central IPM Center will hold the "Integrated Tick Management Symposium: Solving America’s Tick-Borne Disease Problem" in Washington, DC, May 16-17, 2016. read more (Source: ESA News)

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Tuesday 10 May 2016

UTSA professor Janakiram Seshu explores new method to stop the spread of Lyme disease

(University of Texas at San Antonio) Medication that is normally used to lower cholesterol could stop the spread of Lyme disease, according to a new study co-authored by Janakiram Seshu, associate professor of biology at The University of Texas at San Antonio. (Source: EurekAlert! - Medicine and Health)


Monday 9 May 2016

Parents’ guide to spring health

Spring has arrived, which means fun in the sun, but it also brings seasonal health concerns for kids. Do you have questions about allergies, ticks and Lyme disease, sun protection or other springtime health concerns? Click on the images below for handy tips to keep your family safe and healthy this spring. var metaslider_29947 = function($) { $('#metaslider_29947').nivoSlider({ boxCols:7, boxRows:5, pauseTime:4000, effect:"fade", controlNav:true, directionNav:true, pauseOnHover:true, animSpeed:600, prevText:"<", nextText:">", slices:15, manualAdvance:false }); }; var ti...


Sunday 8 May 2016

Housecall: Hand-Washing Do's and Don'ts

THIS WEEK'S TOP STORIES Hand-washing: Do's and don'ts Done properly, hand-washing is a simple way to avoid getting sick. Find out when to wash and whether hand sanitizers can work in a pinch. Lyme disease Grassy and heavily wooded areas can be home to ticks, which can carry Lyme disease. Get tips on how to [...] (Source: News from Mayo Clinic)

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Saturday 7 May 2016

The heat is on: Killing blacklegged ticks in residential washers and dryers to prevent tickborne diseases

Publication date: Available online 28 April 2016 Source:Ticks and Tick-borne Diseases Author(s): Christina A. Nelson, Catherine M. Hayes, Molly A. Markowitz, Jacqueline J. Flynn, Alan C. Graham, Mark J. Delorey, Paul S. Mead, Marc C. Dolan Reducing exposure to ticks can help prevent Lyme disease and other tickborne diseases. Although it is currently recommended to dry clothes on high heat for one hour to kill ticks on clothing after spending time outdoors, this recommendation is based on a single published study of tick survival under various washing conditions and a predetermined one-hour drying time. We conducted a series of tests to investigate the effects of temperature, humidity, and drying time on killing nymphal and adult blacklegged ticks (Ixodes scapularis). Muslin bags ...


Saturday 7 May 2016

Molecular detection of Anaplasma platys, Ehrlichia canis, Hepatozoon canis and Rickettsia monacensis in dogs from Maio Island of Cape Verde archipelago

This study focused on the molecular identification of tick-borne pathogens in blood samples of 153 autochthonous asymptomatic dogs in Maio Island, Cape Verde archipelago. Eighty-four (54.9%) dogs were positive for one or more pathogens. Fifty-five (35.9%) dogs were infected with Hepatozoon canis, 53 (34.6%) with Anaplasma platys, five (3.3%) with Ehrlichia canis and Rickettsia monacensis, an emerging human pathogen, was also identified in a single dog (0.7%). The former three pathogens cause important canine tick-borne diseases that are transmitted or potentially transmitted by Rhipicephalus sanguineus s.l., the only hard tick identified in Cape Verde. Furthermore, Wolbachia spp. was amplified from the blood of one dog. None of the dogs were positive for Anaplasma phagocytophilum, Borrelia...


Friday 6 May 2016

Take the Lyme Disease Challenge: Make My Birthday Wish Come True

Although I have a background in writing about health and mental illness, I had never done so from a personal point of view until last fall when I began to discuss Lyme disease here. Within hours of the first article's publication, I had received a dozen emails, tweets and Facebook messages from Lyme patients, researchers, advocates and others. Within a couple of days, at least a hundred people had contacted me. I never expected such a reaction--but the reason I decided to write about Lyme is that when I was in diagnostic hell, I had no idea where to look for information, or even what to look for. (Yes, I ended a sentence with a preposition. Birthday privilege.) Today is my 38th birthday. While I've felt since about age 21 that birthdays aren't such a big deal for adults, I am celebrating...


Thursday 5 May 2016

David Cameron receives letter from 11-year old who was denied NHS funding for physio

Ben Baddeley, 11, of Newcastle-under-Lyme, has learned to walk for the first time thanks to £2,000-a-month physiotherapy. He is begging David Cameron for NHS funding for the treatment. (Source: the Mail online | Health)


Thursday 5 May 2016

'Please help me Mr Cameron': 11-year-old with cerebral palsy delivers letter to 10 Downing Street after being denied NHS funding for physio to help him walk

Ben Baddeley, 11, of Newcastle-under-Lyme, has learned to walk for the first time thanks to £2,000-a-month physiotherapy. He is begging David Cameron for NHS funding for the treatment. (Source: the Mail online | Health)


Thursday 5 May 2016

Largest Lyme Disease Trial Finds No Benefit with Long-Term Antibiotics

No abstract available (Source: Neurology Today)


Thursday 5 May 2016

Interaction of the Lyme disease spirochete with its tick vector

Summary Borrelia burgdorferi, the causative agent of Lyme disease (along with closely related genospecies), is in the deeply branching spirochete phylum. The bacterium is maintained in nature in an enzootic cycle that involves transmission from a tick vector to a vertebrate host and acquisition from a vertebrate host to a tick vector. During its arthropod sojourn, B. burgdorferi faces a variety of stresses, including nutrient deprivation. Here, we review some of the spirochetal factors that promote persistence, maintenance, and dissemination of B. burgdorferi in the tick, and then focus on the utilization of available carbohydrates as well as the exquisite regulatory systems invoked to adapt to the austere environment between blood meals and to signal species transitions as the bacteria tr...


Thursday 5 May 2016

Human pathogens associated with the blacklegged tick Ixodes scapularis: a systematic review

The blacklegged tick Ixodes scapularis transmits Borrelia burgdorferi (sensu stricto) in eastern North America; however, the agent of Lyme disease is not the sole pathogen harbored by the blacklegged tick. The bl... (Source: Parasites and Vectors)

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Tuesday 3 May 2016

Dramatic response to a 3-week course of ceftriaxone in late neuroborreliosis mimicking atypical dementia and normal pressure hydrocephalus

We report a patient with features of atypical dementia and normal pressure hydrocephalus (NPH), who improved dramatically after a single 3-week course of ceftriaxone. (Source: Journal of the Neurological Sciences)


Tuesday 3 May 2016

Predictive Factors for Differentiating Between Septic Arthritis and Lyme Disease of the Knee in Children

Conclusions: Although septic arthritis of the knee and Lyme monoarthritis share common features that can make them difficult to distinguish clinically, the presence of pain with short arc motion, C-reactive protein of >4.0 mg/L, patient-reported history of fever, and age younger than 2 years were independent predictive factors of septic arthritis in pediatric patients. The more factors that are present, the higher the risk of having septic arthritis. Level of Evidence: Diagnostic Level III. See Instructions for Authors for a complete description of levels of evidence. (Source: JBJS)


Tuesday 3 May 2016

A Borrelia burgdorferi Surface-Exposed Transmembrane Protein Lacking Detectable Immune Responses Supports Pathogen Persistence and Constitutes a Vaccine Target

Borrelia burgdorferi harbors a limited set of transmembrane surface proteins, most of which constitute key targets of humoral immune responses. Here we show that BB0405, a conserved membrane-spanning protein of unknown function, fails to evoke detectable antibody responses despite its extracellular exposure. bb0405 is a member of an operon and ubiquitously expressed throughout the rodent-tick infection cycle. The gene product serves an essential function in vivo, as bb0405-deletion mutants are unable to transmit from ticks and establish infection in mammalian hosts. Despite the lack of BB0405-specific immunoglobulin M or immunoglobulin G antibodies during natural infection, mice immunized with a recombinant version of the protein elicited high-titer and remarkably long-lasting antibody res...


Tuesday 3 May 2016

Diagnosis of Lyme disease in the pediatric acute care setting

Purpose of review: We review the current evidence concerning the diagnosis of Lyme disease in children for application in the acute care setting. Recent findings: Recent studies suggest that Lyme disease incidence is substantially higher than previously described. Although efforts are ongoing to identify alternative testing strategies, two-tiered serologic testing remains the diagnostic standard in children with compatible clinical syndromes. Published clinical prediction rules can assist clinicians caring for children with potential Lyme disease. Summary: Two-tiered serologic testing remains the mainstay of the diagnosis of Lyme disease. To minimize the risk of a false positive test, serologic testing should be limited to those children with symptoms compatible with Lyme disease with po...

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Monday 2 May 2016

Diagnostic pitfalls in a young Romanian ranger with an acute psychotic episode

We present the case of a 35-year-old ranger who had no history of acute or chronic infectious disease or any previous neuropsychiatric symptoms. He arrived at the Psychiatry Clinic and was admitted as an emergency case, displaying bizarre behavior, hallucinations, paranoid ideation, and delusional faults. These symptoms had first appeared 7 days earlier. An objective examination revealed abnormalities of behavior, anxiety, visual hallucinations, choreiform, and tic-like facial movements. After the administration of neuroleptic and antidepressant treatment, he showed an initial improvement, but on day 10 entered into a severe catatonic state with signs of meningeal irritation and was transferred to the intensive care unit. An electroencephalogram showed diffuse irritative changes,...


Monday 2 May 2016

Lyme Disease.

Authors: Hu LT Abstract This issue provides a clinical overview of Lyme disease, focusing on prevention, diagnosis, treatment, and practice improvement. The content of In the Clinic is drawn from the clinical information and education resources of the American College of Physicians (ACP), including MKSAP (Medical Knowledge and Self-Assessment Program). Annals of Internal Medicine editors develop In the Clinic in collaboration with the ACP's Medical Education and Publishing divisions and with the assistance of additional science writers and physician writers. PMID: 27136224 [PubMed - as supplied by publisher] (Source: Annals of Internal Medicine)


Monday 2 May 2016

False Positive Lyme Disease IgM Immunoblots in Children

In our cross-sectional sample of 7289 serologic tests for Lyme disease, we identified 167 instances of a positive IgM immunoblot but a negative IgG immunoblot test result. Considering that only 71% (95% CI 64%-78%) of patients had Lyme disease, a positive IgM immunoblot alone should be interpreted with caution to avoid over-diagnosis of Lyme disease. (Source: The Journal of Pediatrics)


Monday 2 May 2016

Efficacy and safety of pharmacological agents in the treatment of erythema migrans in early Lyme borreliosis—systematic review protocol

Discussion Benefits and harms of pharmacological treatment in erythema migrans have not yet been adequately assessed. This systematic review will evaluate and summarise available evidence addressing benefits and harms of different pharmacological treatments. In addition, this summary of clinical evidence will inform decision-making between clinicians and patients and will play an important part in patient care. Systematic review registration PROSPERO: CRD42016037932 (Source: Systematic Reviews)


Saturday 30 April 2016

Skin infections in pregnancy

A wide array of infectious diseases can occur in pregnancy. Their acquisition, clinical presentation, and course during gestation may be altered due to an impairment of the maternal cellular immunity. Some infectious diseases can lead to serious consequences for the mother or the offspring, including congenital malformations. This review describes in detail the clinical presentation, course, management, and associated maternal and fetal risks of selected viral (varicella-zoster virus infections, condylomata acuminata), fungal (candida vulvovaginitis), bacterial (Lyme borreliosis), and parasitic (scabies) infections. (Source: Clinics in Dermatology)

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Saturday 30 April 2016

Evaluation of Six Recombinant Proteins for Serological Diagnosis of Lyme Borreliosis in China.

CONCLUSION: Three recombinant antigens, OspC B.g, OspC B.a, and VlsE B.a, were useful for ELISAs of LB. Additionally, the interaction between OspC B.a and Fla B.g should be examined in future research. PMID: 27353706 [PubMed - in process] (Source: Biomedical and Environmental Sciences : BES)


Saturday 30 April 2016

Retrospective Evaluation of Horses Diagnosed with Neuroborreliosis on Postmortem Examination: 16 Cases (2004–2015)

Conclusion and Clinical ImportanceDiagnosis of equine NB is challenging due to variable clinical presentation and lack of sensitive and specific diagnostic tests. Negative serology and normal CSF analysis do not exclude the diagnosis of NB. (Source: Journal of Veterinary Internal Medicine)



Thursday 28 April 2016

'Lyme disease is a ticking time bomb'

Dr Hany Elsheikha, associate professor of parasitology at the University of Nottingham, says Lyme disease is one of the fastest-growing diseases in the Western world. (Source: the Mail online | Health)


Wednesday 27 April 2016

What Is Lyme Disease?

You may have seen singer Avril Lavigne’s recent media appearances discussing her experience with Lyme disease.  What is this mysterious illness, and how can you tell if you have it? -- Read more on ScientificAmerican.com (Source: Scientific American)


Tuesday 26 April 2016

Review of Lyme Disease, Human Granulocytic Anaplasmosis, and Babesiosis

This narrative review summarizes published evidence about the diagnosis, treatment, and prevention of Lyme disease, human granulocytic anaplasmosis, and babesiosis. (Source: JAMA)

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Tuesday 26 April 2016

Lyme Disease Serology

A 10-year-old girl’s 2.0-cm annular lesion on the neck persists following 10 days of antifungal therapy, and she undergoes serologic testing for Lyme disease, which shows equivocal enzyme immunoassay results and negative immunoblots. How do you interpret results? (Source: JAMA)


Monday 25 April 2016

Detection of IFN-{gamma} Secretion by T Cells Collected Before and After Successful Treatment of Early Lyme Disease

Conclusions. Our findings suggest that measurement of IFN- after incubating blood with Borrelia antigens could be useful in the laboratory diagnosis of early Lyme disease. Also, after antibiotic treatment, this response appears to be short lived. (Source: Clinical Infectious Diseases)


Monday 25 April 2016

New test for early detection of Lyme disease developed

As part of the EU "ID Lyme" project, an infection immunology team is working on developing of a new test for early detection of Lyme disease (borreliosis). This will improve the ability to detect an active infection more easily than before so that healthy people with Lyme disease antibodies in their blood do not receive unnecessary antibiotic treatment and so that appropriate treatments can be initiated at an early stage. The antibody tests that are currently available only provide a reliable result 3 – 4 weeks after infection has occurred. (Source: ScienceDaily Headlines)

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Monday 25 April 2016

Atrophosclerodermic manifestations of lyme borreliosis

(Bentham Science Publishers) This review summarizes the literature on scleratrophic skin lesions as a manifestation of a Borrelia infection. (Source: EurekAlert! - Medicine and Health)


Sunday 24 April 2016

The Past, Present, and (Possible) Future of Serologic Testing for Lyme Disease [Minireviews]

Lyme disease prevails as the most commonly transmitted tick-borne infection in the United States, and serologic evaluation for antibodies to Borrelia burgdorferi remains the recommended modality for diagnosis. This review presents a brief historical perspective on the evolution of serologic assays for Lyme disease and provides a summary of the performance characteristics for the currently recommended two-tiered testing algorithm (TTTA). Additionally, a recently proposed alternative to the traditional TTTA is discussed, and novel methodologies, including immuno-PCR and metabolic profiling for Lyme disease, are outlined. (Source: Journal of Clinical Microbiology)


Sunday 24 April 2016

Imbalanced presence of Borrelia burgdorferi s.l. multilocus sequence types in clinical manifestations of Lyme borreliosis.

In this study we used typing based on the eight multilocus sequence typing scheme housekeeping genes (MLST) and 5S-23S rDNA intergenic spacer (IGS) to explore the population structure of Borrelia burgdorferi sensu lato isolates from patients with Lyme borreliosis (LB) and to test the association between the B. burgdorferi s.l. sequence types (ST) and the clinical manifestations they cause in humans. Isolates of B. burgdorferi from 183 LB cases across Europe, with distinct clinical manifestations, and 257 Ixodes ricinus lysates from The Netherlands, were analyzed for this study alone. For completeness, we incorporated in our analysis also 335 European B. burgdorferi s.l. MLST profiles retrieved from literature. Borrelia afzelii and Borrelia bavariensis were associated with human cases of LB...

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Sunday 24 April 2016

[Psoriasis migrans : Erythema migrans as Koebner phenomenon in psoriasis].

Authors: Ständer S, Ständer M, Thomas P, Prinz JC, Wolf R Abstract Psoriasis is a chronic inflammatory disorder of the epidermis, which can be induced by systemic factors, such as streptococci infections or drugs. In addition, psoriasis can be caused by a local cutaneus trauma, known as Koebner phenomenon. Here, we describe a woman with psoriasis in remission, who developed a new psoriatic lesion due to a cutaneous infection with Borrelia burgdorferi. After causal therapy with doxycycline, the erythema migrans and psoriasis lesions disappeared. PMID: 27106503 [PubMed - as supplied by publisher] (Source: Der Hautarzt: Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete)


Friday 22 April 2016

Comparison of males versus females with culture-confirmed early Lyme disease at presentation and at 11 –20 years after diagnosis

Lyme disease is the most common vector-borne infection in the United States with 300,000 estimated cases per year. (Source: Diagnostic Microbiology and Infectious Disease)


Friday 22 April 2016

Comparison of Males versus Females with Culture-Confirmed Early Lyme Disease at Presentation and at 11–20 Years After Diagnosis

Lyme disease is the most common vector-borne infection in the United States with 300,000 estimated cases per year. (Source: Diagnostic Microbiology and Infectious Disease)


Friday 22 April 2016

Spring is here! Tick and Lyme disease prevention tips

Springtime temperatures and warmer, sun-filled days are synonymous with outdoor play. Kids of all ages shed their winter jackets; break out their tricycles, bicycles and more, and head outside for playtime. But outdoor activities are also synonymous with tick exposure. So how can you prepare your family for the tick season? The Boston Children’s Hospital’s Director of Infectious Disease Outpatient Practice, Dr. Catherine Lachenauer offers tips on how to avoid tick exposure and steps to take if your child gets a tick bite. “First and foremost, prevention is key,” says Lachenauer. “Avoid areas at the edge of the woods with long grasses. Also, wearing long, light-colored clothing helps keep ticks from getting on the skin and makes it easier to recognize one on your body.” Tic...


Thursday 21 April 2016

Susceptibility to Ticks and Lyme Disease Spirochetes Is Not Affected in Mice Coinfected with Nematodes [Fungal and Parasitic Infections]

Small rodents serve as reservoir hosts for tick-borne pathogens, such as the spirochetes causing Lyme disease. Whether natural coinfections with other macroparasites alter the success of tick feeding, antitick immunity, and the host's reservoir competence for tick-borne pathogens remains to be determined. In a parasitological survey of wild mice in Berlin, Germany, approximately 40% of Ixodes ricinus-infested animals simultaneously harbored a nematode of the genus Heligmosomoides. We therefore aimed to analyze the immunological impact of the nematode/tick coinfection as well as its effect on the tick-borne pathogen Borrelia afzelii. Hosts experimentally coinfected with Heligmosomoides polygyrus and larval/nymphal I. ricinus ticks developed substantially stronger systemic type 2 T helper ce...


Thursday 21 April 2016

Functional Equivalence of OspA and OspB, but Not OspC, in Tick Colonization by Borrelia burgdorferi [Molecular Pathogenesis]

Borrelia burgdorferi, a Lyme disease agent, makes different major outer surface lipoproteins at different stages of its mouse–tick infectious cycle. Outer surface protein A (OspA) coats the spirochetes from the time they enter ticks until they are transmitted to a mammal. OspA is required for normal tick colonization and has been shown to bind a tick midgut protein, indicating that OspA may serve as a tick midgut adhesin. Tick colonization by spirochetes lacking OspA is increased when the infecting blood meal is derived from mice that do not produce antibody, indicating that OspA may protect the spirochetes from host antibody, which will not recognize tick-specific proteins such as OspA. To further study the importance of OspA during tick colonization, we constructed a form of B. bur...

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Thursday 21 April 2016

[Corrections] Corrections

Pritt BS, Mead PS, Hoang Johnson DK, et al. Identification of a novel pathogenic Borrelia species causing Lyme borreliosis with unusually high spirochaetaemia. Lancet Infect Dis 2016; 16: 556–64—In figure 4 of this Article, there were several spelling mistakes. B bisseti DN127 should have read B bissettii DN127, B kurenbachii IL96-255 should have read B kurtenbachii IL96-255, B balaisiana VS116 should have read B valaisiana VS116, B varariensis PZwi should have read B bavariensis PZwi, and B californiensis SCW-22 should have read B carolinensis SCW-22. (Source: The Lancet Infectious Diseases)


Wednesday 20 April 2016

Autophagy suppresses host adaptive immune responses toward Borrelia burgdorferi.

Authors: Buffen K, Oosting M, Li Y, Kanneganti TD, Netea MG, Joosten LA Abstract We have previously demonstrated that inhibition of autophagy increased the ITALIC! Borrelia burgdorferiinduced innate cytokine production in vitro, but little is known regarding the effect of autophagy on in vivo models of ITALIC! Borreliainfection. Here, we showed that ATG7-deficient mice that were intra-articular injected with ITALIC! Borreliaspirochetes displayed increased joint swelling, cell influx, and enhanced interleukin-1β and interleukin-6 production by inflamed synovial tissue. Because both interleukin-1β and interleukin-6 are linked to the development of adaptive immune responses, we examine the function of autophagy on ITALIC! Borreliainduced adaptive immunity. Human peripheral blood mon...


Wednesday 20 April 2016

Post-Lyme Syndrome–Associated Polyneuropathy Treated With Immune Immunoglobulin and a Luteolin-Containing Formulation

No abstract available (Source: Journal of Clinical Psychopharmacology)


Wednesday 20 April 2016

Treatment of Lyme Disease

Date:  May 9, 2016 Issue #:  1494 Summary:  Most cases of Lyme disease in the US occur between May and September in the Northeastern, Mid-Atlantic, and North Central states. (Source: The Medical Letter)


Wednesday 20 April 2016

Genetic and immunological evidences of borrelia burgdorferi in dog in thailand.

GENETIC AND IMMUNOLOGICAL EVIDENCES OF BORRELIA BURGDORFERI IN DOG IN THAILAND. Southeast Asian J Trop Med Public Health. 2016 Jan;47(1):71-7 Authors: Sthitmatee N, Jinawan W, Jaisan N, Tangjitjaroen W, Chailangkarn S, Sodarat C, Ekgatat M, Padungtod P Abstract Lyme disease is a tick-borne zoonotic disease caused by spirochete Borrelia burgdorferi. It is transmitted from animals to humans by the bite of infected ticks of the genus Ixodes. Although Lyme disease has been reported in China and Japan, the disease has never been reported in Thailand. Blood samples and ticks were collected from 402 dogs from 7 and 3 animal clinics in Chiang Mai and Phuket Provinces, Thailand, respectively. Blood samples were tested for antibodies against B. burgdorferi, Anaplasma spp, Ehrlic...

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Tuesday 19 April 2016

Flow-Tolerant Adhesion of a Bacterial Pathogen to Human Endothelial Cells Through Interaction With Biglycan

Conclusions. The proteoglycan biglycan is a receptor molecule for flow-resistant adhesion of the bacterial pathogen B. garinii on human endothelial cells. (Source: The Journal of Infectious Diseases)


Tuesday 19 April 2016

Prevalence of vector-borne pathogens in dogs from Haiti

Publication date: Available online 19 April 2016 Source:Veterinary Parasitology Author(s): Lindsay A. Starkey, Kassie Newton, Jill Brunker, Kelly Crowdis, Emile Jean Pierre Edourad, Pedro Meneus, Susan E. Little Canine vector-borne pathogens are common on some Caribbean islands, but survey data in Haiti are lacking. To determine the prevalence of selected vector-borne pathogens in dogs from Haiti, we tested blood samples collected from 210 owned dogs, 28 (13.3%) of which were infested with Rhipicephalus sanguineus ticks at the time of blood collection. No other tick species were identified on these dogs. A commercially available ELISA identified antibodies to Ehrlichia spp. in 69 (32.9%), antibodies to Anaplasma spp. in 37 (17.6%), and antigen of Dirofilaria immitis in 55 (26.2%);...


Monday 18 April 2016

Yamamoto New Scalp Acupuncture, Applied Kinesiology, and Breathing Exercises for Facial Paralysis in a Young Boy Caused by Lyme Disease—A Case Report

Publication date: Available online 2 March 2016 Source:EXPLORE: The Journal of Science and Healing Author(s): Friedrich Molsberger, C. Raak, M. Teuber The case study reports on the effect of pharmacological, complementary, and alternative medicine including YNSA, Applied Kinesiology, and respiratory exercises in a 9-year-old boy with facial paralysis. The boy suffered from borreliosis and one-sided facial paralysis that occurred 3.5 weeks after being bitten by a tick and persisted despite 4 weeks of medication with antibiotics. In the first treatment, muscle function as assessed by the coachman׳s test was normalized, and improvement in the facial paralysis was observed. Within 8 additional treatments over a period of 2 months, the boy showed complete recovery. The case shows a multim...


Wednesday 13 April 2016

Why We Need New Antibiotics More Than Ever

This article was produced in partnership with Northeastern University and was originally published on Footnote, a website that brings academic research and ideas to a broader audience. A year ago, a group of scientists led by Dr. Kim Lewis, Director of the Antimicrobial Discovery Center at Northeastern University, announced a major breakthrough. They had identified a new antibiotic, teixobactin, capable of destroying several kinds of bacteria, including antibiotic-resistant strains of tuberculosis and staph (i.e. MRSA).1 Antibiotics are so familiar to us that the discovery of a new one may not seem particularly groundbreaking. Yet in reality, most antibiotics were identified over a half-century ago and new discoveries are quite rare. Teixobactin is actually "the first new antibiotic to be ...


Tuesday 12 April 2016

Cary Institute receives $5 million for study on reducing ticks, Lyme disease

(Cary Institute of Ecosystem Studies) The Steven & Alexandra Cohen Foundation has awarded a $5 million leadership grant to the Cary Institute of Ecosystem Studies to support a scientific study, being done in partnership with Bard College, that seeks to reduce Lyme disease in neighborhoods. (Source: EurekAlert! - Medicine and Health)


Sunday 10 April 2016

No Value for Routine Serologic Screening for Borrelia burgdorferi in Patients With Uveitis in the Netherlands

To determine whether routine serologic screening for Borrelia burgdorferi and subsequent aqueous or vitreous humor analysis is useful in patients with uveitis. (Source: American Journal of Ophthalmology)

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Sunday 10 April 2016

No value for routine serological screening for B. burgdorferi in patients with uveitis in the Netherlands

To determine whether routine serological screening for Borrelia burgdorferi and subsequent aqueous or vitreous humour analysis is useful in patient with uveitis. (Source: American Journal of Ophthalmology)


Friday 8 April 2016

Cimetidine as a Novel Adjunctive Treatment for Early Stage Lyme Disease

Lyme disease, caused by the spirochete Borrelia burgdorferi (Bb), is the most common vector-borne illness in the United States. It is a complex disease which may affect the skin, joints, heart, eyes, and central nervous system. Prompt diagnosis and treatment is curative in most instances. However, a significant percentage of patients experience ongoing symptoms after treatment. Currently, there is much controversy regarding the diagnosis, pathophysiology, and treatment of Lyme disease. Pathogen persistence despite treatment lies at the heart of this debate. (Source: Medical Hypotheses)


Friday 8 April 2016

Cimetidine as a novel adjunctive treatment for early stage Lyme disease

Lyme disease, caused by the spirochete Borrelia burgdorferi (Bb), is the most common vector-borne illness in the United States. It is a complex disease which may affect the skin, joints, heart, eyes, and central nervous system. Prompt diagnosis and treatment is curative in most instances. However, a significant percentage of patients experience ongoing symptoms after treatment. Currently, there is much controversy regarding the diagnosis, pathophysiology, and treatment of Lyme disease. Pathogen persistence despite treatment lies at the heart of this debate. (Source: Medical Hypotheses)


Friday 8 April 2016

New Lyme Disease Study Reveals Strong Reporting Bias

This study is a useful contribution to ongoing investigations of how to treat ongoing Lyme disease symptoms among patients who have received the standard 28-day course of doxycycline and continue to experience severe symptoms commonly associated with Lyme disease. This study is also significant because, unlike the majority of Lyme disease-related studies published in peer-reviewed medical journals, it made international headlines in mainstream news outlets. Some publications that specialize in medical and health-related stories covered the story appropriately, such as Medscape, whose headline reads, "Post-Treatment Lyme Disease: Longer Antibiotics May Not Help." Others, perhaps most notably Forbes, created their own exaggerated version of the findings. Forbes contributor Steven Salzberg an...

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Friday 8 April 2016

Treating Lyme disease: when will science catch up?

Cases of Lyme disease appear to be rising but there are still many unanswered questions about the condition, its diagnosis and the available treatment options. (Source: The Pharmaceutical Journal)


Thursday 7 April 2016

Tocilizumab efficacy in a patient with positive anti-CCP chronic Lyme arthritis

Conclusion: Off label treatment by biologic disease modifying antirheumatic drugs can be considered in selected patients with severe antibiotic-resistant Lyme arthritis.C. (Source: North American Journal of Medical Sciences)


Thursday 7 April 2016

Lyme Disease

Title: Lyme DiseaseCategory: Diseases and ConditionsCreated: 12/31/1997 12:00:00 AMLast Editorial Review: 4/7/2016 12:00:00 AM (Source: MedicineNet Arthritis General)


Tuesday 5 April 2016

Lyme Time Is upon Us Again

The arrival of spring means we need to start being careful outside—in more places than ever -- Read more on ScientificAmerican.com (Source: Scientific American)

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Monday 4 April 2016

Long-Term Antibiotic Use For Lyme Disease Doesn't Work, Study Finds

Chronic Lyme Disease is a myth, yet thousands of patients are treated with long-term antibiotics, lasting months or years, by "Lyme literate" doctors who insist that their patients have the disease. A new study examined the question of whether lengthy antibiotic treatments provides any benefit over a simple two-week course, and found no difference. Scientific studies going back to 2001 have found the same thing, but "Lyme literate" docs have banded together to form societies that insist they are right, and that continue to recruit patients, solicit donations, and prescribe antibiotic treatments that last for years. (Source: Forbes.com Healthcare News)


Sunday 3 April 2016

The Evaluation and Management of Alternative Diagnoses in Amyotrophic Lateral Sclerosis (P5.091)

Conclusions: Treatment with intravenous steroids, immunoglobulin and surgical interventions prior to diagnosis of ALS is associated with a significantly prolonged mean ODI.Disclosure: Dr. Kannan has nothing to disclose. Dr. Glass has nothing to disclose. (Source: Neurology)


Sunday 3 April 2016

Human Immunodeficiency Virus Seroconversion Syndrome Presenting as Facial Diplegia and Aseptic Meningitis: A Case Report (P1.327)

We describe an HIV seroconversion syndrome presenting with facial diplegia and aseptic meningitis. DESCRIPTION: Patient is a 44 year old male with known uncontrolled hypertension. Three weeks prior to presentation he suffered a transient febrile illness while vacationing and was treated presumptively for malaria in Côte d’Ivoire. One week later, he experienced a migrainous headache with pronounced bucco-labial dysarthria, meningismus and dysguesia. Examination revealed hypertensive urgency, bilateral lower motor neuron (LMN) facial paralysis, and mild meningeal irritation. Initial investigations revealed renal impairment (acute on chronic) and left ventricular hypertrophy, both ascribed to presumed chronic hypertension. Gradient echo sequence of brain MRI revealed microhemorrha...


Sunday 3 April 2016

Delayed Neuromyelitis Optica Masqueraded as Post Viral Encephalomyelitis (P6.159)

CONCLUSIONS Viral infection can be the triggering mechanism for the development of NMO disease.Disclosure: Dr. Rothstein has nothing to disclose. Dr. Majidi has nothing to disclose. (Source: Neurology)


Sunday 3 April 2016

A Case of Dipeptidyl-Peptidase-Like Protein-6 (DPPX) Autoantibody Mediated Autoimmune Encephalitis with Prominent Abnormal Movements During Sleep (P6.140)

Conclusions: We report a case of autoimmune encephalitis due to antibodies against DPPX, which featured a fluctuating course and prominent abnormal movements, which persisted during sleep. Diarrhea, previously associated with DPPX associated encephalitis, was absent. This case highlights the clinical heterogeneity of autoimmune encephalitis and the diagnostic challenges that can lead to treatment delays.Disclosure: Dr. Gusdon has nothing to disclose. Dr. Kaunzner has nothing to disclose. Dr. Sekar has nothing to disclose. Dr. Jamieson has received personal compensation for activities with Bayer and Boehringer-Ingelheim as a consultant and a speaker. (Source: Neurology)


Sunday 3 April 2016

B-Cell Lymphoma Presenting as Bilateral Facial Nerve Palsy: Case Report and Literature Review (P2.264)

Conclusions: Unlike unilateral facial nerve palsy, Bilateral Facial Nerve Palsy is a rarely idiopathic. It has diverse etiologies and includes life threatening conditions. We reinforce the fact that it needs thorough work up and inpatient admission.Disclosure: Dr. Singh has nothing to disclose. (Source: Neurology)


Sunday 3 April 2016

Isolated Tongue Hemi-Atrophy from Hypoglossal-Vertebral Entrapment Syndrome (P3.377)

Conclusion: Hypoglossal vertebral entrapment syndrome from a structural vascular anomaly or anomalous vascular course is an extremely rare cause of isolated hypoglossal nerve palsy. Only a few cases have been reported in the literature. Imaging studies and careful exclusion of other potential etiologies is essential to establish the diagnosis.Disclosure: Dr. Roy has nothing to disclose. Dr. Bakradze has nothing to disclose. Dr. Ollenschleger has nothing to disclose. Dr. Felice has nothing to disclose. (Source: Neurology)

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Sunday 3 April 2016

Chronic Multifocal Inflammatory Myeloneuropathy: A Novel Immunoresponsive Clinical Entity (P3.142)

Conclusions: We bring to your attention a novel case series of chronic, inflammatory immunoresponsive myeloneuropathy with very unique clinical syndrome.Disclosure: Dr. Mitrabhakdi has nothing to disclose. Dr. Goodman has nothing to disclose. Dr. Laothamatas has nothing to disclose. Dr. Lewis has received personal compensation for activities with CSL Behring, Pharnext, Novartis, and Axelacare. (Source: Neurology)


Sunday 3 April 2016

Unusual Neurological Presentation in a Patient with Known Metastatic Prostate Cancer (P3.369)

We present the interesting case of a 71 year old gentleman, previously diagnosed with metastic prostate cancer, presenting with confusion and Abdominal pain. During his hospital admission he developed Renal Impairment and Spastic paraparesis with a sensory level up to T10 dermatome. Results of Investigations: A wide panel of investigations was performed. The most significant were: Creatinine 329umol/L, Hb 8.4g/dl, platelets 51,000, LDH 395,000. Blood film pointed towards a haemolytic state. MRI spine showed showed abnormal intramedullary T2 signal in the distal cord extends from T8/T9 disk space to the conus likely cord infarct or transverse myelitis. In addition he had stable bony me; MRI brain showed small vessel ischemic changes. CSF was normal. Blood tests were sent for vitamin B12 &am...


Saturday 2 April 2016

PodMed: A Medical News Roundup From Johns Hopkins (with audio)

(MedPage Today) -- This weeks topics include home care and survival, timing of HRT, Lyme disease and long-term antibiotics, and cardiac procedures before surgery (Source: MedPage Today Cardiovascular)


Thursday 31 March 2016

Anterocollis and startle myoclonus due to Lyme meningomyeloradiculitis

(Source: Acta Neurologica Belgica)


Thursday 31 March 2016

April consultation #5

This patient's clinical presentation, with peripheral noninfectious, stromal keratitis, is highly suggestive of and most often associated with an underlying systemic immune-mediated disease, although other etiologies such as neoplasia can masquerade in a similar manner. The contiguous pattern involving several clock hours of the peripheral cornea while maintaining relatively good vision and little inflammation throughout the uninvolved stroma further supports a nonmicrobial cause. Uncommon exceptions to this include ocular tuberculosis, syphilis, leprosy, and Lyme disease, which can all mimic peripheral noninfectious keratitis. (Source: Journal of Cataract and Refractive Surgery)

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Thursday 31 March 2016

Post-Lyme-Disease Syndrome: Longer Antibiotics May Not HelpPost-Lyme-Disease Syndrome: Longer Antibiotics May Not Help

Longer courses of antibiotics do not improve health-related quality of life in patients with post-Lyme-disease syndrome, according to a new study. Medscape Medical News (Source: Medscape Allergy Headlines)


Thursday 31 March 2016

Study: longer-term antibiotics won't ease chronic Lyme disease

Steven Reinberg and HealthDay News People with persistent symptoms associated with Lyme disease are unlikely to find relief from longer-term antibiotic therapy, according to a new Dutch study. (Source: Health News - UPI.com)

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Thursday 31 March 2016

Antibiotics for Lyme Disease -- How Long is Enough?

How long to treat patients with Lyme remains an issue of controversy. With traditional antibiotic therapy, lasting 2-4 weeks, 10-20% of patients will have ongoing symptoms including fatigue, joint pain, insomnia, and complaints of “brain fog.” Indefinite long-term treatment is advocated by ILADS (International Lyme and Associated Diseases Society), based on a patient’s symptoms. In contrast, IDSA (Infectious Disease Society of America ) only recommends 2-4 weeks treatment. The two groups are bitter adversaries. (Source: Forbes.com Healthcare News)


Wednesday 30 March 2016

Study: Longer-Term Antibiotics Won't Ease 'Chronic Lyme Disease'

Dutch trial is latest to show no benefit from extended treatment, but finding unlikely to end the controversy (Source: WebMD Health)


Wednesday 30 March 2016

Prolonged Therapy Shows No Benefit for Persistent Lyme Disease Symptoms (FREE)

By Larry M. Baddour, MD Dr. Baddour is editor-in-chief of NEJM Journal Watch Infectious Diseases, from which this story was adapted. Full coverage is available to subscribers at the link below.Longer-term therapy does not improve quality of life … (Source: Physician's First Watch current issue)


Wednesday 30 March 2016

Long-term antibiotic therapy ineffective for persistent Lyme symptoms

(Reuters Health) - Twelve weeks of antibiotic therapy proved ineffective at combating the long-term symptoms seen in some people who have had Lyme disease, a new test of 280 sufferers found. (Source: Reuters: Health)


Wednesday 30 March 2016

Long-Term Antibiotics Fail Again in Lyme Disease (CME/CE)

(MedPage Today) -- Focus on Lyme and antibiotics for persistent symptoms called unhelpful (Source: MedPage Today Infectious Disease)

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Wednesday 30 March 2016

Study: Longer-Term Antibiotics Won't Ease 'Chronic Lyme Disease'

Dutch trial is latest to show no benefit from extended treatment, but finding unlikely to end the controversy Source: HealthDay Related MedlinePlus Pages: Antibiotics, Lyme Disease (Source: MedlinePlus Health News)


Wednesday 30 March 2016

Long-term antibiotics ineffective for persistent Lyme disease

Long-term is no better than standard antibiotic therapy for persistent symptoms of Lyme disease, according to a report published online March 30 in the New England Journal of Medicine. Randomized... (Source: Clinical Neurology News)


Wednesday 30 March 2016

Study: Longer-Term Antibiotics Won't Ease 'Chronic Lyme Disease'

Dutch trial is latest to show no benefit from extended treatment, but finding unlikely to end the controversy (Source: U.S. News - Health)


Wednesday 30 March 2016

Long-term antibiotics ineffective for persistent Lyme disease

Long-term is no better than standard antibiotic therapy for persistent symptoms of Lyme disease, according to a report published online March 30 in the New England Journal of Medicine. Randomized... (Source: Family Practice News)


Wednesday 30 March 2016

Long-term antibiotics ineffective for persistent Lyme disease

Long-term is no better than standard antibiotic therapy for persistent symptoms of Lyme disease, according to a report published online March 30 in the New England Journal of Medicine. Randomized... (Source: Rheumatology News)


Tuesday 29 March 2016

Spring health cheat sheet

The beginning of spring often brings warm weather and hours of outdoor fun, and many common winter infections recede. Unfortunately, spring weather can bring its own health challenges. As soon as the trees and flowers bloom, flowers bud and the grass grows, susceptible children will start to display symptoms of seasonal allergies. Seasonal allergies cause sneezing, runny nose and itchy red eyes and can trigger flares of asthma and eczema. As children spend more time outdoors, parents also need to watch for exposure to ticks, poison ivy and excess sun. Read on for the parents’ guide to spring health. Seasonal allergies: symptoms to look for Allergic rhinitis About one in five children develops seasonal allergy symptoms. In New England, tree pollen begins affecting susceptible individuals...


Tuesday 29 March 2016

Real-Time PCR studies regarding the borrelia burgdorferi, francisella tularensis, tick borne encephalitis virus (TBEv) and crimeean congo hemorrhagic fever virus (CCHFv) occurrence in the Romanian ticks

Background: Our studies undertaken between 2006-2015 have shown that the most frequent species of ticks in Romania is Ixodes ricinus. It was found that I. ricinus is the main vector in Romania for the Borrelia burgdorferi s.l. and for the TBEv, but no data were available for Francisella tularensis and CCHFv infectious agents occurrence into I.ricinus and Hyalomma sp. (Source: International Journal of Infectious Diseases)


Tuesday 29 March 2016

Researchers investigate four promising new treatments for Lyme disease

(Northeastern University) According to the Cen­ters for Dis­ease Con­trol and Pre­ven­tion, about 300,000 people are diag­nosed with Lyme dis­ease in the US each year. Uni­ver­sity Dis­tin­guished Pro­fessor Kim Lewis, who leads the Lyme dis­ease research team, is now expanding that ther­a­peutic reach with the help of a $1.5 mil­lion grant from the Steven and Alexandra Cohen Foundation. (Source: EurekAlert! - Biology)


Monday 28 March 2016

An Open Letter to the Boston Globe About Lyme Disease

Today, the Boston Globe editorial board spoke out against a bill "that would require insurers in Massachusetts to cover Lyme disease treatments for as long as a doctor says they're needed." The Globe writes: Lawmakers may have good intentions, but they don't possess the expertise to decide whether it's beneficial, cost-efficient, or safe, to keep using strong medicines to treat a condition the medical establishment doubts is real. Such questions should be resolved by a consensus of doctors and researchers -- and buttressed by convincing clinical date [sic] -- not determined by legislative mandate. Who among the Boston Globe editorial board possesses the medical expertise to make this call is not disclosed, but this information would be useful given that the Globe's stance presumes absolute...


Friday 25 March 2016

Susceptibility, likelihood to be diagnosed, worry and fear for contracting Lyme disease

This study investigates the four separate outcomes of susceptibility, likelihood to be diagnosed, worry, and fear for contracting Lyme disease. University students (n=713) were surveyed about demographics, perceived health, Lyme disease knowledge, Lyme disease preventive behaviors, Lyme disease history, and Lyme disease miscellaneous variables. We found that women were associated with increased susceptibility and fear. (Source: Journal of Infection and Public Health)


Friday 25 March 2016

Lyme: Fight Harder For Science and End This War

I just had a flashback. When I was diagnosed with Lyme, I knew little about it. I went to the first infectious disease doctor with my bullseye still present, asking lots of questions. Among them, are you sure this three weeks of doxycycline is enough. He smiled, and with his eyes fixed on his computer, he said, "Yes, it's more than enough. In fact, I could just tell you to take ten days but then you'd come back later if anything went haywire and ask why I didn't give you twenty-one." He looked up, "Call me if anything goes crazy." A month later, I called. I woke up with a very sore throat and fever two days before my brother's wedding and a gland in my neck that felt like a pulsating grape. It was movable but scarily large. He said if it didn't go down in a few weeks, to let him know. It d...


Friday 25 March 2016

Antibiotics Side Effects on the Mitochondria

Science is just beginning to understand how important your mitochondria are to warding off the diseases of aging. And, as usual, mainstream medicine is lagging way behind. Along with your telomeres, the cellular time keepers at the ends of your chromosomes, your mitochondria are another key component of the anti-aging equation. You see, these tiny organelles in your cells are the power plants that turn fuel into energy for your body. Healthy mitochondria keep you young and energetic.  Research shows that damaged mitochondria can lead to: Schizophrenia and bipolar disorder; Alzheimer’s and Parkinson’s disease; Epilepsy, migraines, and nerve pain; Loss of muscle control and balance; Strokes, heart disease, and coronary artery disease; Chronic fatigue syndrome and fibromyalgia;...

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Friday 25 March 2016

The diagnostic accuracy of serological tests for Lyme borreliosis in Europe: a systematic review and meta-analysis

Interpretation of serological assays in Lyme borreliosis requires an understanding of the clinical indications and the limitations of the currently available tests. We therefore systematically reviewed the acc... (Source: BMC Infectious Diseases)


Tuesday 22 March 2016

An 89-year-old man presents with worsening heart failure

Clinical introduction An 89-year-old man with a history of heart failure with preserved ejection fraction presented with worsening dyspnoea, reduced exercise capacity and peripheral oedema. His medical history was significant for hypertension, paroxysmal atrial fibrillation (AF), chronic obstructive pulmonary disease and Lyme disease (1983). Admission cardiovascular medications included aspirin 75 mg once a day, perindopril 6 mg once a day, furosemide 40 mg two times a day, flecainide 100 mg two times a day and simvastatin 40 mg one a night. On examination, he was normothermic and clinically in heart failure with raised jugular venous pressure, bibasal pulmonary crepitations and oedema up to abdomen. Cardiac markers were negative. Other laboratory tests demonstrate...


Tuesday 22 March 2016

Serological survey on some pathogens in wild brown hares (Lepus europaeus) in Central Italy

Conclusion The obtained results showed that B. burgdorferi s.l. N. caninum, T. gondii, A. phagocytophilum and Leishmania sp circulate in wild brown hares in Central Italy, suggesting a possible role of L. europaeus as reservoir of these pathogens. The obtained results showed that autochthonous wild brown hares living in Central Italy have been exposed to several pathogens circulating in this area, suggesting a possible role of L. europaeus as reservoir. (Source: Asian Pacific Journal of Tropical Medicine)



Tuesday 22 March 2016

Tick-borne bacterial pathogens in southwestern Finland

Ixodes ricinus and Ixodes persulcatus are the main vectors of Lyme borreliosis spirochetes and several other zoonotic bacteria in northern Europe and Russia. However, few studies scree... (Source: Parasites and Vectors)

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Monday 21 March 2016

Id: 62: hemophagocytic lymphohistiocytosis caused by infection by ehrlichia chaffeensis: a case report.

We present a case of HLH triggered by severe infection with Ehrlichia chaffeensis in a patient taking methotrexate for seronegative spondyloarthropathy. A 45-year-old man with a history of ankylosing spondylitis taking methotrexate presented to a community hospital with acute onset of nausea, vomiting and diarrhea. Physical examination revealed a febrile patient with diffuse abdominal tenderness with splenomegaly and diffuse maculopapular rash involving the trunk and all extremities. Labs showed leukopenia and thrombocytopenia. Clinical course was complicated by development of acute renal failure, altered mental status and hypoxic respiratory failure requiring endotracheal intubation and mechanical ventilation. Plasmapheresis was initiated due to concern for thrombotic thrombocytopenic pur...


Monday 21 March 2016

Id: 53: sever symptomatic babesiosis co-infection with lyme disease

Discussion Humans are opportunistic hosts to Babesia when bitten by nymph or adult ticks; the most known ticks are Ixodes. Babesiosis should be considered in patients who have a malaria-like illness in areas endemic for Babesia infection. The symptoms usually begin 2–4 weeks after a tick bite. The presentation includes constitutional symptoms, abdominal pain and dark urine. Labs finding include hemolytic anemia and elevated liver enzymes. Urinalysis reveals hemoglobinuria without red blood cells. The diagnosis of Babesiosis is usually established by microscopic examination of Giems or Wright-stained blood smears, indirect immunofluorescent antibody tests and PCR. In healthy individuals with intact spleens, the symptoms resolve spontaneously without treatment. For mild to moderate bab...


Monday 21 March 2016

Controversial New Push to Tie Microbes to Alzheimer's Disease

A journal article says herpes virus and Lyme disease bacteria are behind the mind-robbing illness, but not all researchers are convinced -- Read more on ScientificAmerican.com (Source: Scientific American)


Sunday 20 March 2016

Borrelia miyamotoi: A human tick-borne relapsing fever spirochete in Europe and its potential impact on public health.

Authors: Siński E, Welc-Falęciak R, Zajkowska J Abstract Borrelia miyamotoi is a tick-borne bacterium which has only recently been identified in Europe as a human pathogen causing relapsing fever and little is known about its local impact on human health. There are three types of B. miyamotoi: Asian (Siberian), European, and American. B. miyamotoi is transmitted by the same Ixodes ricinus-persulcatus species complex, which also transmits B. burgdorferi s.l., the Lyme borreliosis group. Both Borrelia groups are mostly maintained in natural rodent populations. The aim of this review is to summarize the available literature on B. miyamotoi, with the focus of attention falling on Europe, as well as to describe its presence in ticks, reservoir hosts, and humans and discuss its potenti...

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Sunday 20 March 2016

Borrelia miyamotoi: A human tick-borne relapsing fever spirochete in Europe and its potential impact on public health

Publication date: Available online 21 March 2016 Source:Advances in Medical Sciences Author(s): Edward Siński, Renata Welc-Falęciak, Joanna Zajkowska Borrelia miyamotoi is a tick-borne bacterium which has only recently been identified in Europe as a human pathogen causing relapsing fever and little is known about its local impact on human health. There are three types of B. miyamotoi: Asian (Siberian), European, and American. B. miyamotoi is transmitted by the same Ixodes ricinus-persulcatus species complex, which also transmits B. burgdorferi s.l., the Lyme borreliosis group. Both Borrelia groups are mostly maintained in natural rodent populations. The aim of this review is to summarize the available literature on B. miyamotoi, with the focus of attention falling on Europe, as well...


Friday 18 March 2016

Nigeria: Emerging and Re-Emerging Diseases - Call for Timely Public Health Response in Nigeria

[Guardian] At present, the World Health Organisation (WHO) is monitoring a couple of infectious diseases, including: Ebola, Lassa fever, Severe Acute Respiratory Syndrome (SARS), Acquired Immune Deficiency Syndrome (AIDS), Haemorrhagic fever, West Nile Virus, and Lyme disease. The rate of re-emergence of infectious disease has been on the increase. Diseases such as cholera, tuberculosis, Influenza (flu), hepatitis and staphylococcus infections thought to have been controlled are re-emerging. A majority of the agents (Source: AllAfrica News: Health and Medicine)


Wednesday 16 March 2016

CD83 Modulates B Cell Activation and Germinal Center Responses.

Authors: Krzyzak L, Seitz C, Urbat A, Hutzler S, Ostalecki C, Gläsner J, Hiergeist A, Gessner A, Winkler TH, Steinkasserer A, Nitschke L Abstract CD83 is a maturation marker for dendritic cells. In the B cell lineage, CD83 is expressed especially on activated B cells and on light zone B cells during the germinal center (GC) reaction. The function of CD83 during GC responses is unclear. CD83(-/-) mice have a strong reduction of CD4(+) T cells, which makes it difficult to analyze a functional role of CD83 on B cells during GC responses. Therefore, in the present study we generated a B cell-specific CD83 conditional knockout (CD83 B-cKO) model. CD83 B-cKO B cells show defective upregulation of MHC class II and CD86 expression and impaired proliferation after different stimuli. Analys...


Wednesday 16 March 2016

Statins reduce spirochetal burden and modulate immune responses in the C3H/HeN mouse model of Lyme disease

Publication date: Available online 16 March 2016 Source:Microbes and Infection Author(s): Tricia A. Van Laar, Camaron Hole, S.L. Rajasekhar Karna, Christine L. Miller, Robert Reddick, Floyd L. Wormley, J. Seshu Lyme disease (LD) is a systemic disorder caused by Borrelia burgdorferi. Lyme spirochetes encode for a functional 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMGR EC 1.1.1.88) serving as a rate limiting enzyme of the mevalonate pathway that contribute to components critical for cell wall biogenesis. Statins have been shown to inhibit B. burgdorferi in vitro. Using a mouse model of Lyme disease, we found that statins contribute to reducing bacterial burden and altering the murine immune response to favor clearance of spirochetes. (Source: Microbes and Infection)


Tuesday 15 March 2016

[Incidence of Lyme disease in Spain].

Authors: Bonet Alavés E, Guerrero Espejo A, Cuenca Torres M, Gimeno Vilarrasa F PMID: 26971976 [PubMed - as supplied by publisher] (Source: Medicina Clinica)


Tuesday 15 March 2016

Blog: Preparing for insect borne diseases

Ticks carrying the bacteria ‘Borrelia’ causing Lyme disease are endemic throughout the UK, and reports of Lyme disease have been steadily increasing with the infection acquired in woodlands, moorlands and parks Hide related content:  Show related content read more (Source: Nursing in Practice)


Friday 11 March 2016

Notes from the Field: Lymphocytic Choriomeningitis Virus Meningoencephalitis from a Household Rodent Infestation - Minnesota, 2015.

Authors: Talley P, Holzbauer S, Smith K, Pomputius W Abstract On April 20, 2015, a female aged 15 years sought care at her pediatrician's office after 5 days of fever, myalgia, left parietal headache, and photophobia. A rapid influenza assay was negative, and erythrocyte sedimentation rate and total white blood cell count were normal. She improved with symptomatic care at home, but returned to her pediatrician's office on April 28, reporting recurrence of her headache and photophobia and new onset of a stiff neck. She was admitted to the hospital, where she was febrile to 102.9°F (39.4°C) and had meningismus. Computed tomography scan of her head was normal, and a cerebrospinal fluid (CSF) analysis showed a markedly elevated white blood cell count with 68% lymphocytes, low glucose...


Friday 11 March 2016

Molecular identification of Borrelia genus in questing hard ticks from Portugal: Phylogenetic characterization of two novel Relapsing Fever-like Borrelia sp.

This study was designed to update the presence of B. burgdorferi s.l. species in ticks from several districts of mainland Portugal, where Ixodes ricinus had been previously described. Ticks (a total of 2915 specimens) were collected in seven districts throughout the country, and analyzed using molecular methods. Three nested-PCR protocols, targeting the flagellin gene (flaB), the intergenic spacer region (IGS) located between 5S and 23S rRNA, and the glpQ gene, and a conventional PCR targeting the 16S rRNA, were used for Borrelia DNA detection. Borrelia DNA was detected in 3% of the ticks from Braga, Vila Real, Lisboa, Setúbal, Évora and Faro districts. The obtained amplicons were sequenced and analyzed by BLASTn, and 15/63 (24%) matched with homologous sequences from Borrelia lusitaniae...

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Thursday 10 March 2016

Serological Detection of Borrelia burgdorferi among Horses in Korea.

Authors: Lee SH, Yun SH, Choi E, Park YS, Lee SE, Cho GJ, Kwon OD, Kwak D Abstract Lyme disease is a tick-borne zoonotic infectious disease caused by Borrelia burgdorferi. The present study assessed the infection status of B. burgdorferi among horses reared in Korea using ELISA and PCR. Between 2009 and 2013, blood samples were collected from 727 horses throughout Korea. Data for each animal including age, gender, breed, and region of sample collection were used for epidemiological analysis. Overall, 38 (5.2%; true prevalence: 5.5%) of 727 horses were seropositive by ELISA. There were statistically significant differences according to breed and region (P<0.001) whose differences might be attributed to the ecology of vector ticks and climate conditions. Using 2 nested PCR, none o...


Thursday 10 March 2016

Sony musician Ren Gill to give up career amid Lyme disease battle

Ren Gill, 25, from Brighton, was first diagnosed with depression and bipolar disorder, then chronic fatigue syndrome but was finally diagnosed with Lyme disease at a clinic in Brussels. (Source: the Mail online | Health)


Tuesday 8 March 2016

Cardiac Tropism of Borrelia burgdorferi

Fatal Lyme carditis caused by the spirochete Borrelia burgdorferi rarely is identified. Here, we describe the pathologic, immunohistochemical, and molecular findings of five case patients. These sudden cardiac deaths associated with Lyme carditis occurred from late summer to fall, ages ranged from young adult to late 40s, and four patients were men. Autopsy tissue samples were evaluated by light microscopy, Warthin-Starry stain, immunohistochemistry, and PCR for B. burgdorferi, and immunohistochemistry for complement components C4d and C9, CD3, CD79a, and decorin. (Source: American Journal of Pathology)

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Tuesday 8 March 2016

Yamamoto new scalp acupuncture, applied kinesiology and breathing exercises for facial paralysis in a young boy caused by Lyme disease – A case report

Discussion The case shows a multimodal approach to facial paralysis integrating pharmacological treatment and CAM including YNSA, Applied Kinesiology and breathing exercises. (Source: EXPLORE: The Journal of Science and Healing)


Tuesday 8 March 2016

Linkages of Weather and Climate With Ixodes scapularis and Ixodes pacificus (Acari: Ixodidae), Enzootic Transmission of Borrelia burgdorferi, and Lyme Disease in North America

Lyme disease has increased both in incidence and geographic extent in the United States and Canada over the past two decades. One of the underlying causes is changes during the same time period in the distribution and abundance of the primary vectors: Ixodes scapularis Say and Ixodes pacificus Cooley and Kohls in eastern and western North America, respectively. Aside from short periods of time when they are feeding on hosts, these ticks exist in the environment where temperature and relative humidity directly affect their development, survival, and host-seeking behavior. Other important factors that strongly influence tick abundance as well as the proportion of ticks infected with the Lyme disease spirochete, Borrelia burgdorferi, include the abundance of hosts for the ticks and the capaci...


Tuesday 8 March 2016

Borrelia burgdorferi induces a type I interferon response during early stages of disseminated infection in mice

Lyme borrelia genotypes differ in their capacity to cause disseminated disease. Gene array analysis was employed to profile the host transcriptome induced by Borrelia burgdorferi strains with different capacities... (Source: BMC Microbiology)


Tuesday 8 March 2016

Infection of Immature Ixodes scapularis (Acari: Ixodidae) by Membrane Feeding

A reduction in the use of animals in infectious disease research is desirable for animal welfare as well as for simplification and standardization of experiments. An artificial silicone-based membrane-feeding system was adapted for complete engorgement of adult and nymphal Ixodes scapularis Say (Acari: Ixodidae), and for infecting nymphs with pathogenic, tick-borne bacteria. Six wild-type and genetically transformed strains of four species of bacteria were inoculated into sterile bovine blood and fed to ticks. Pathogens were consistently detected in replete nymphs by polymerase chain reaction. Adult ticks that ingested bacteria as nymphs were evaluated for transstadial transmission. Borrelia burgdorferi and Ehrlichia muris-like agent showed high rates of transstadial transmission to adult ...


Tuesday 8 March 2016

County-Scale Distribution of Ixodes scapularis and Ixodes pacificus (Acari: Ixodidae) in the Continental United States

The blacklegged tick, Ixodes scapularis Say, is the primary vector to humans in the eastern United States of the Lyme disease spirochete Borrelia burgdorferi, as well as causative agents of anaplasmosis and babesiosis. Its close relative in the far western United States, the western blacklegged tick Ixodes pacificus Cooley and Kohls, is the primary vector to humans in that region of the Lyme disease and anaplasmosis agents. Since 1991, when standardized surveillance and reporting began, Lyme disease case counts have increased steadily in number and in geographical distribution in the eastern United States. Similar trends have been observed for anaplasmosis and babesiosis. To better understand the changing landscape of risk of human exposure to disease agents transmitted by I. scapularis an...


Tuesday 8 March 2016

Cardiac Tropism of

Fatal Lyme carditis caused by the spirochete Borrelia burgdorferi rarely is identified. Here, we describe the pathologic, immunohistochemical, and molecular findings of five case patients. These sudden cardiac deaths associated with Lyme carditis occurred from late summer to fall, ages ranged from young adult to late 40s, and four patients were men. Autopsy tissue samples were evaluated by light microscopy, Warthin-Starry stain, immunohistochemistry, and PCR for B. burgdorferi, and immunohistochemistry for complement components C4d and C9, CD3, CD79a, and decorin. (Source: American Journal of Pathology)


Tuesday 8 March 2016

New Records of Ixodes affinis (Acari: Ixodidae) Parasitizing Avian Hosts in Southeastern Virginia

This study presents evidence of I. affinis parasitizing five new host passerine species. During 2012–2014, 1,888 birds were captured and examined for ticks, and 18 immature I. affinis were collected from 12 birds—six Carolina Wrens (Thyrothorus ludovicianus); two Brown Thrashers (Toxostoma rufum); and one American Robin (Turdus migratorius), Eastern Towhee (Pipilo erythrophthalmus), Northern Cardinal (Cardinalis cardinalis), and White-throated Sparrow (Zonotrichia albicollis). Of 15 larvae and 3 nymphs collected, one nymph tested positive for B. burgdorferi DNA. I. affinis was found co-feeding on birds with immature Amblyomma americanum (L.), Ixodes brunneus Koch, Ixodes dentatus Marx, Ixodes scapularis Say, and Haemaphysalis leporispalustris Packard. The results of this resear...

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Tuesday 8 March 2016

Cardiac Tropism of Borrelia burgdorferi: An Autopsy Study of Sudden Cardiac Death Associated with Lyme Carditis.

Authors: Muehlenbachs A, Bollweg BC, Schulz TJ, Forrester JD, DeLeon Carnes M, Molins C, Ray GS, Cummings PM, Ritter JM, Blau DM, Andrew TA, Prial M, Ng DL, Prahlow JA, Sanders JH, Shieh WJ, Paddock CD, Schriefer ME, Mead P, Zaki SR Abstract Fatal Lyme carditis caused by the spirochete Borrelia burgdorferi rarely is identified. Here, we describe the pathologic, immunohistochemical, and molecular findings of five case patients. These sudden cardiac deaths associated with Lyme carditis occurred from late summer to fall, ages ranged from young adult to late 40s, and four patients were men. Autopsy tissue samples were evaluated by light microscopy, Warthin-Starry stain, immunohistochemistry, and PCR for B. burgdorferi, and immunohistochemistry for complement components C4d and C9, CD3,...


Monday 7 March 2016

Molecular survey on zoonotic tick-borne bacteria and chlamydiae in feral pigeons (Columba livia domestica)

Conclusions Feral pigeons living in urban and periurban areas are a hazard for the human health as source of several pathogens. The obtained results confirm pigeons as reservoirs of chlamydial agents and suggest that they may be involved in the epidemiology of zoonotic tick-borne infections too. (Source: Asian Pacific Journal of Tropical Medicine)


Saturday 5 March 2016

Postepy Hig Med Dosw 2016; 70:180-185 "Serum carnitine concentration is decreased in patients with Lyme borreliosis"

Conclusions: LB patients exhibit a significant decrease of their serum carnitine concentrations. The largest changes were in the NB and PLD patients. To prevent late complications of the disease a possibility of early supplementation with carnitine should be considered. Further studies are required to explain the pathophysiological significance of our findings. (Source: Postepy higieny i medycyny doswiadczalnej)


Saturday 5 March 2016

Geographical differences in seroprevalence of Borrelia burgdorferi antibodies in Norway, 2011–2013

Publication date: Available online 27 February 2016 Source:Ticks and Tick-borne Diseases Author(s): Didrik F. Vestrheim, Richard A. White, Ingeborg S. Aaberge, Audun Aase Detection of specific antibodies against Borrelia burgdorferi sensu lato is a useful aid for the diagnosis of Lyme borreliosis. However, antibodies are present in the general population. The seroprevalence increase with age, and varies according to the prevalence of infected ticks. We performed a seroprevalence study of IgM and IgG antibody reactivity against B. burgdorferi sensu lato in Norway by age-groups and geography, in order to provide a reference set of seroprevalence to inform the interpretation of positive test results. We used two commercially available enzyme immuno assays (EIA) and a multiplexed bead as...


Tuesday 1 March 2016

What Clinicians Should Know About the New Lyme SpeciesWhat Clinicians Should Know About the New Lyme Species

Borrelia burgdorferi isn't the only bacterial species causing Lyme disease in the United States. Learn about emerging tickborne infections and how they differ from 'traditional' Lyme disease. Medscape Infectious Diseases (Source: Medscape Infectious Diseases Headlines)

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Tuesday 1 March 2016

Tick-Borne Illnesses

Tick-borne diseases are prevalent throughout the United States. These illnesses are caused by a variety of different pathogens that use ticks as vectors, including bacteria, viruses, rickettsia, and protozoa. Some of the most common illnesses caused by ticks are Lyme disease, Rocky Mountain spotted fever, babesiosis, ehrlichiosis, anaplasmosis, tularemia, Colorado tick fever, tick-borne relapsing fever, and Powassan disease. Unique skin changes, fever, and influenza-like symptoms may indicate tick-borne disease. Early diagnosis can be difficult as well as nonspecific and can resemble overtraining syndrome. Diagnosis is important to facilitate early treatment to decrease morbidity and mortality and should often be initiated before a definitive diagnosis is made. Treatment guidelines are pub...

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Tuesday 1 March 2016

An Unrecognized Rash Progressing to Lyme Carditis: Important Features and Recommendations Regarding Lyme Disease

We present a case report of 46-year-old man with no medical history, who complained of extreme fatigue, near-syncope, and palpitations. He initially presented in complete heart block. A transvenous pacemaker was placed in the emergency department, and he was started empirically on Ceftriaxone for Lyme disease. He was admitted and over the course of the next few days, his rhythm regressed to Mobitz type I first-degree atrioventricular block and then to normal sinus rhythm. This case report highlights some important features regarding Lyme carditis, a rare presentation of early disseminated Lyme disease (seen in a few weeks to months after the initial tick bite). In 25%–30% of patients, the characteristic targetoid rash may not be seen, a likely culprit of the disease not being detected ea...


Tuesday 1 March 2016

Yamamoto new scalp acupuncture, applied kinesiology and breathing exercises for facial paralysis in a young boy caused by Lyme disease – A case report

The case study reports on the effect of pharmacological, complementary and alternative medicine including YNSA, Applied Kinesiology and respiratory exercises in a 9-year old boy with facial paralysis. (Source: Explore)


Tuesday 1 March 2016

Lyme Disease Surveillance Using Sampling Estimation: Evaluation of an Alternative Methodology in New York State

Summary In the 14‐year period from 1993 to 2006, New York State (NYS) accounted for over one‐quarter (27.1%) of all confirmed Lyme disease (LD) cases in the United States. During that time period, a nine‐county area in south‐east NYS accounted for 90.6% of the reported LD cases in the state. Based on concerns related to diminishing resources at both the state and local level and the increasing burden of traditional LD surveillance, the NYS Department of Health (DOH) sought to develop an alternative to traditional surveillance that would reduce the investigative workload while maintaining the ability to track LD trends by developing a system to estimate county‐level LD cases based on a 20% random sample of positive laboratory reports. Estimates from this system were compared to ob...


Tuesday 1 March 2016

Molecular epidemiological surveillance to assess emergence and re-emergence of tick-borne infections in tick samples from China evaluated by nested PCRs.

Authors: Yu PF, Niu QL, Liu ZJ, Yang JF, Chen Z, Guan GQ, Liu GY, Luo JX, Yin H Abstract An investigation was performed to detect eight pathogens in ticks collected from grass tips or animals in the southern, central and northeast regions of China. DNA samples extracted from ticks were collected from ten different locations in eight provinces of China and subjected to screening for tick-borne pathogens, including Borrelia burgdorferi sensu lato, Ehrlichia spp., Rickettsia spp., Babesia/Theileria spp., Ehrlichia ruminantium, Coxiella burnetii, and Francisella tularensis, using nested PCR assays and sequencing analysis. The results indicated that Borrelia spp., Rickettsia spp., and Babesia/Theileria spp. were detected in all of the investigated provinces. Ehrlichia spp. was also foun...

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Tuesday 1 March 2016

Emerging Cases of Powassan Virus Encephalitis in New England: Clinical Presentation, Imaging, and Review of the Literature

Conclusions. We describe 8 cases of POWV encephalitis in Massachusetts and New Hampshire in 2013–2015. Prior to this, there had been only 2 cases of POWV encephalitis identified in Massachusetts. These cases may represent emergence of this virus in a region where its vector, I. scapularis, is known to be prevalent or may represent the emerging diagnosis of an underappreciated pathogen. We recommend testing for POWV in patients who present with encephalitis in the spring to fall in New England. (Source: Clinical Infectious Diseases)


Tuesday 1 March 2016

Tick-Borne Illnesses.

Authors: Choi E, Pyzocha NJ, Maurer DM Abstract Tick-borne diseases are prevalent throughout the United States. These illnesses are caused by a variety of different pathogens that use ticks as vectors, including bacteria, viruses, rickettsia, and protozoa. Some of the most common illnesses caused by ticks are Lyme disease, Rocky Mountain spotted fever, babesiosis, ehrlichiosis, anaplasmosis, tularemia, Colorado tick fever, tick-borne relapsing fever, and Powassan disease. Unique skin changes, fever, and influenza-like symptoms may indicate tick-borne disease. Early diagnosis can be difficult as well as nonspecific and can resemble overtraining syndrome. Diagnosis is important to facilitate early treatment to decrease morbidity and mortality and should often be initiated before a de...


Tuesday 1 March 2016

Turning #LymeintoLemonAid Thanks to My PICC Line

I was told that I was a moody teenage girl in need of antidepressants and psychotherapy, that I didn't stretch enough before and after sports so I should see a physical therapist, that I was tired because school started so early, that it was all in my head, and that I was just a clumsy person who should stop complaining. Seven years later, I was diagnosed with chronic neurologic Lyme disease and coinfections of Babesia and Bartonella. (Source: Journal of the Association for Vascular Access)


Monday 29 February 2016

Yamamoto New Scalp Acupuncture, Applied Kinesiology, and Breathing Exercises for Facial Paralysis in a Young Boy Caused by Lyme Disease —A Case Report

The case study reports on the effect of pharmacological, complementary, and alternative medicine including YNSA, Applied Kinesiology, and respiratory exercises in a 9-year-old boy with facial paralysis. The boy suffered from borreliosis and one-sided facial paralysis that occurred 3.5 weeks after being bitten by a tick and persisted despite 4 weeks of medication with antibiotics. In the first treatment, muscle function as assessed by the coachman ׳s test was normalized, and improvement in the facial paralysis was observed. (Source: Explore)


Monday 29 February 2016

Yamamoto New Scalp Acupuncture, Applied Kinesiology, and Breathing Exercises for Facial Paralysis in a Young Boy Caused by Lyme Disease—A Case Report

The case study reports on the effect of pharmacological, complementary, and alternative medicine including YNSA, Applied Kinesiology, and respiratory exercises in a 9-year-old boy with facial paralysis. The boy suffered from borreliosis and one-sided facial paralysis that occurred 3.5 weeks after being bitten by a tick and persisted despite 4 weeks of medication with antibiotics. In the first treatment, muscle function as assessed by the coachman׳s test was normalized, and improvement in the facial paralysis was observed. (Source: Explore)


Sunday 28 February 2016

Ageing, Drama and Creativity: Translating Research into Practice.

This article describes how the course was developed and how participants were selected; details its aims and objectives; provides an overview of the sessions and a flavour of some of the exercises that were used; and considers findings from the structured evaluation alongside written reflections from participants. PMID: 26905617 [PubMed - as supplied by publisher] (Source: Gerontology and Geriatrics Education)

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Sunday 28 February 2016

Geographical differences in seroprevalence of Borrelia burgdorferi antibodies in Norway, 2011-2013

Publication date: Available online 27 February 2016 Source:Ticks and Tick-borne Diseases Author(s): Didrik F. Vestrheim, Richard A. White, Ingeborg S. Aaberge, Audun Aase Detection of specific antibodies against Borrelia burgdorferi sensu lato is a useful aid for the diagnosis of Lyme borreliosis. However, antibodies are present in the general population. The seroprevalence increase with age, and varies according to the prevalence of infected ticks. We performed a seroprevalence study of IgM and IgG antibody reactivity against B. burgdorferi sensu lato in Norway by age-groups and geography, in order to provide a reference set of seroprevalence to inform the interpretation of positive test results. We used two commercially available enzyme immuno assays (EIA) and a multiplexed bead as...


Thursday 25 February 2016

Lyme Disease 'Biofilm' Eludes Antibiotics: Report

Germ forms slimy layer that makes it up to 1,000 times more resistant than other bacteria, researchers say (Source: U.S. News - Health)


Thursday 25 February 2016

Lyme Disease 'Biofilm' Eludes Antibiotics

Germ forms slimy layer that makes it up to 1,000 times more resistant than other bacteria, researchers say Source: HealthDay Related MedlinePlus Pages: Antibiotics, Lyme Disease (Source: MedlinePlus Health News)


Wednesday 24 February 2016

Phosphoenolpyruvate Phosphotransferase System Components Modulate Gene Transcription and Virulence of Borrelia burgdorferi [Molecular Pathogenesis]

We examined 12 PEP-PTS transporter component mutants by needle inoculation of mice to assess their ability to cause mouse infection. Transposon mutants with mutations in the EIIBC components (ptsG) (BB0645, thought to be involved in glucose-specific transport) were unable to cause infection in mice, while all other tested PEP-PTS mutants retained infectivity. Infectivity was partially restored in an in trans-complemented strain of the ptsG mutant. While the ptsG mutant survived normally in unfed as well as fed ticks, it was unable to cause infection in mice by tick transmission, suggesting that the function of ptsG is essential to establish infection by either needle inoculation or tick transmission. In Gram-negative organisms, the regulatory effects of the PEP-PTS are mediated by adenylat...


Tuesday 23 February 2016

Tick Management Symposium to Be Held in DC in May

Annapolis, MD; February 23, 2016 – Ticks that transmit Lyme disease and other pathogens have been spreading geographically, and increased numbers of illnesses are being diagnosed. To address this issue, a symposium on Integrated Tick Management will be held May 16-17, 2016 in Washington, DC by the U.S. Centers for Disease Control and Prevention, the Entomological Society of America, the IPM Institute of North America, and the North Central IPM Center. The symposium aims to: read more (Source: ESA News)


Tuesday 23 February 2016

4 ways to protect your family from mosquitoes

.Follow me at @drClaire The news about the Zika virus possibly causing microcephaly in infants has everyone talking about — and worried about — mosquitoes. It’s not just the Zika virus that can be spread by mosquitoes; these insects also spread other illnesses, such as malaria, dengue, chikungunya, yellow fever, West Nile virus, eastern equine encephalitis, and Japanese encephalitis. It should be said that most people who are bitten by mosquitoes don’t get sick with anything. But if you are living in or traveling to an area where these illnesses are prevalent, it’s important to know the four best ways to protect yourself and your family: Choose your clothes wisely. Lightweight long sleeves and long pants are your best bet; spraying clothing with insect repellent may help even mo...


Tuesday 23 February 2016

Tick management symposium to be held in Washington, DC in May

(Entomological Society of America) Ticks that transmit Lyme disease and other pathogens have been spreading geographically, and increased numbers of illnesses are being diagnosed. To address this issue, a symposium on Integrated Tick Management will be held May 16-17, 2016 in Washington, DC by the US Centers for Disease Control and Prevention, the Entomological Society of America, the IPM Institute of North America, and the North Central IPM Center. (Source: EurekAlert! - Infectious and Emerging Diseases)

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Tuesday 23 February 2016

Genome reveals insights into tick that spreads Lyme disease

Researchers deciphered the genome of the blacklegged tick, which causes several diseases, including Lyme disease. The resource can aid development of new ways to control ticks. (Source: NIH Research Matters from the National Institutes of Health (NIH))


Tuesday 23 February 2016

Empirical third-generation cephalosporin therapy for adults with community-onset Enterobacteriaceae bacteraemia: impact of revised CLSI breakpoints

Bacteraemia is a life-threatening condition associated with high morbidity and mortality [1] and is typically complicated by severe sepsis or septic shock [2]. Third-generation cephalosporins (3GCs), such as cefotaxime (CTX) and ceftriaxone (CRO), have remarkable potency against all Enterobacteriaceae and have been established as an appropriate parenteral treatment of various community-onset infections caused by susceptible organisms, such as complicated urinary tract infections, lower respiratory tract infections, bacterial meningitis, bacteraemia, connective tissue infections, pelvic inflammatory disease, intra-abdominal infections and Lyme disease [3,4]. (Source: International Journal of Antimicrobial Agents)


Monday 22 February 2016

Probable doxycycline-induced acute pancreatitis.

CONCLUSION: A man developed AP three days after starting therapy with oral doxycycline, and the association between drug and reaction was determined to be probable. His case appears to be the third of doxycycline-associated AP, although tigecycline, tetracycline, and minocycline have also been implicated as causes of AP. PMID: 26896500 [PubMed - in process] (Source: American Journal of Health-System Pharmacy : AJHP)

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Sunday 21 February 2016

Efficacy of sarolaner in the prevention of Borrelia burgdorferi and Anaplasma phagocytophilum transmission from infected Ixodes scapularis to dogs

Publication date: Available online 20 February 2016 Source:Veterinary Parasitology Author(s): Nicole A. Honsberger, Robert H. Six, Thomas J. Heinz, Angela Weber, Sean P. Mahabir, Thomas C. Berg The efficacy of sarolaner (Simparica™, Zoetis) to prevent transmission primarily of Borrelia burgdorferi and secondarily of Anaplasma phagocytophilum from infected wild-caught Ixodes scapularis to dogs was evaluated in a placebo-controlled laboratory study. Twenty-four purpose-bred laboratory Beagles seronegative for B. burgdorferi and A. phagocytophilum antibodies were allocated randomly to one of three treatment groups: placebo administered orally on Days 0 and 7, or sarolaner at 2mg/kg administered orally on Day 0 (28 days prior to tick infestation) or on Day 7 (21 days prior to tick in...


Saturday 20 February 2016

Larvae of Ixodes ricinus transmit Borrelia afzelii and B. miyamotoi to vertebrate hosts

Lyme borreliosis is the most common tick-borne human disease and is caused by Borrelia burgdorferi sensu lato (s.l.). Borrelia miyamotoi, a relapsing fever spirochaete, is transmitted transovarially, whereas this... (Source: Parasites and Vectors)


Friday 19 February 2016

Lyme Disease in Hispanics, United States, 2000-2013.

Authors: Nelson CA, Starr JA, Kugeler KJ, Mead PS Abstract Hispanics comprise a growing portion of the US population and might have distinct risk factors for tickborne diseases. During 2000-2013, a total of 5,473 Lyme disease cases were reported among Hispanics through national surveillance. Hispanics were more likely than non-Hispanics to have signs of disseminated infection and onset during fall months. PMID: 26889721 [PubMed - as supplied by publisher] (Source: Emerging Infectious Diseases)


Friday 19 February 2016

IV Therapy “Cocktail” For a Cancer Patient

Today, I want to talk to you about my patient D.B. A key treatment I offer at the Sears Institute for Anti-Aging Medicine turned her life around and boosted her chances of recovering from cancer. D.B had been a vivacious 47-year-old woman, who’d always led a healthy life. For years, she’d watched her diet carefully and exercised regularly. But then she was diagnosed with endometrial cancer. This is cancer of the inner lining of the uterus. When she came to my clinic, she’d already undergone a hysterectomy and chemotherapy. Unsurprisingly, she felt terrible. She was pale. She felt lethargic and she was experiencing severe mental fog. Every moment of her life had become a struggle. It was clear right away that D.B. was deficient in several important nutrients. It was also clear her im...


Friday 19 February 2016

Lyme: The Infectious Disease Equivalent of Cancer, Says Top Duke Oncologist

Last week, I mentioned the case of Dr. Neil Spector, whose long-undiagnosed Lyme Disease resulted in irreversible heart failure and ultimately, a heart transplant. Dr. Spector, author of Gone in a Heartbeat: A Physician's Search for True Healing, is the Sandra Coates Associate Professor of Medicine and Associate Professor of Pharmacology and Cancer Biology at Duke University School of Medicine. As the Director of Developmental Therapeutics at the Duke Cancer Institute, he's a leader in applying translational research to the clinical development of molecularly targeted personalized cancer therapies. Here, Dr. Spector shares his story, explains what Lyme and cancer have in common (hint: a LOT), and encourages us with his vision for the future. Like so many of us, your Lyme was missed by mu...


Thursday 18 February 2016

New Bacterial Species Causes Lyme DiseaseNew Bacterial Species Causes Lyme Disease

U.S. researchers say they have discovered a new bacterial species that causes Lyme disease in humans. Reuters Health Information (Source: Medscape Pathology Headlines)


Thursday 18 February 2016

[PCR-based detection of pathogens in clinical rheumatology].

Authors: Ehrenstein B, Reischl U Abstract In the differential diagnostics of autoimmune-mediated rheumatic diseases, rheumatologists often have to consider infections (e. g. Lyme arthritis) or reactive diseases (e. g. reactive arthritis after urogenital bacterial infections). Furthermore, infections with an atypical presentation or caused by atypical pathogens (opportunistic infections) can complicate the immunosuppressive therapy of autoimmune diseases. For this purpose not only conventional microbiological culture methods but also PCR-based methods are increasingly being applied for the direct detection of pathogens in clinical specimens. The aim of this overview is to present commonly used PCR methods in the clinical practice of rheumatology and to describe their benefits an...


Tuesday 16 February 2016

New Cause for Lyme Disease Complicates Already Murky Diagnosis

Scientists claim a novel bacterium causes some different symptoms, adding to the body of research showing the complexity of the disease  -- Read more on ScientificAmerican.com (Source: Scientific American)

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Monday 15 February 2016

A New Culprit in Lyme Disease

Researchers have discovered a second bacterium that may cause the condition. (Source: NYT Health)

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Monday 15 February 2016

New Gene Discovery Could Lead To Earlier Lyme Test And Diagnosis

An experimental new test holds great promise for diagnosing Lyme disease soon after infection, well before current tests are able to detect infection. (Source: Forbes.com Healthcare News)


Sunday 14 February 2016

Sexual transmission of Lyme disease: challenging the tickborne disease paradigm.

Authors: Stricker RB, Middelveen MJ Abstract Lyme disease caused by the spirochete Borrelia burgdorferi has become a major worldwide epidemic. In this article, we explore the clinical, epidemiological and experimental evidence for sexual transmission of Lyme disease in animal models and humans. Although the likelihood of sexual transmission of the Lyme spirochete remains speculative, the possibility of Lyme disease transmission via intimate human contact merits further study. PMID: 26489537 [PubMed - in process] (Source: Expert Review of Anti-Infective Therapy)


Saturday 13 February 2016

Big data and patient-powered research aim to solve complex diseases

(LymeDisease.org) Big data and patient-driven research networks have the power to accelerate our understanding of some of today's most complex diseases. Lorraine Johnson, CEO of Lymedisease.org, will give a presentation at the AAAS meeting on Feb. 13 on 'Big Data and Patient Powered Networks.' She will discuss how MyLymeData, the first and only national patient-powered research project on chronic Lyme disease, is being embraced by thousands of patients, anxious for answers that will improve their lives. (Source: EurekAlert! - Infectious and Emerging Diseases)


Saturday 13 February 2016

Vector competence of the blacklegged tick, Ixodes scapularis, for the recently recognized Lyme borreliosis spirochete Borrelia mayonii

Publication date: Available online 12 February 2016 Source:Ticks and Tick-borne Diseases Author(s): Marc C. Dolan, Andrias Hojgaard, J. Charles Hoxmeier, Adam J. Replogle, Laurel B. Respicio-Kingry, Christopher Sexton, Martin A. Williams, Bobbi S. Pritt, Martin E. Schriefer, Lars Eisen A novel species within the Borrelia burgdorferi sensu lato complex, provisionally named Borrelia mayonii, was recently found to be associated with Lyme borreliosis in the Upper Midwest of the United States. Moreover, B. mayonii was detected from host-seeking Ixodes scapularis, the primary vector of Borrelia burgdorferi sensu stricto in the eastern United States. We therefore conducted a study to confirm the experimental vector competence of I. scapularis for B. mayonii (strain MN14-1420), using c...


Friday 12 February 2016

New experimental test detects signs of Lyme disease near time of infection

An experimental method developed by researchers appears capable of detecting the stealthy culprit Lyme bacteria at the earliest time of infection, when currently available tests are often still negative. (Source: ScienceDaily Headlines)


Friday 12 February 2016

Gene signature could lead to a new way of diagnosing Lyme Disease

Researchers may have found a new way to diagnose Lyme disease, based on a distinctive gene “signature” they discovered in white blood cells of patients infected with the tick-borne bacteria. (Source: ScienceDaily Headlines)


Friday 12 February 2016

Gene Discovery Could Point to New Lyme Disease Test: Study

Researchers say patients have tell-tale genetic signatures, even after taking antibiotics (Source: U.S. News - Health)

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Friday 12 February 2016

Gene signature could lead to a new way of diagnosing Lyme

(University of California - San Francisco) Researchers at UC San Francisco and Johns Hopkins may have found a new way to diagnose Lyme disease, based on a distinctive gene 'signature' they discovered in white blood cells of patients infected with the tick-borne bacteria. (Source: EurekAlert! - Infectious and Emerging Diseases)


Friday 12 February 2016

New experimental test detects signs of Lyme disease near time of infection

(National Institute of Standards and Technology (NIST)) Team from NIST and Johns Hopkins suggests the novel approach might also be useful for early detection of other elusive bacterial infections. (Source: EurekAlert! - Infectious and Emerging Diseases)



Thursday 11 February 2016

Borrelia mayonii is new cause of Lyme disease variant

A new species of Borrelia has been linked to a variant of Lyme disease with symptoms that differ somewhat from typical Lyme borreliosis. Of 100,545 routine clinical specimens tested at the... (Source: Rheumatology News)


Thursday 11 February 2016

Borrelia mayonii is new cause of Lyme disease variant

A new species of Borrelia has been linked to a variant of Lyme disease with symptoms that differ somewhat from typical Lyme borreliosis. Of 100,545 routine clinical specimens tested at the Mayo Clinic in Rochester, Minn., for Lyme borreliosis between 2003 and 2014, six clinical specimens –... (Source: Skin and Allergy News)


Thursday 11 February 2016

How Lyme disease is spread is revealed by unraveling tick's DNA

Scientists from Purdue University in Indiana found the genome of Lyme disease-spreading ticks is 'far more similar to mammals than insects' - and that the ticks' saliva allows them to feed off a host for days. (Source: the Mail online | Health)


Wednesday 10 February 2016

Medical Evidence Supports Denial Of LTD Claim, Federal Judge Determines

PITTSBURGH - Because there is significant medical evidence supporting a disability plan's denial of a claim for long-term disability (LTD) benefits related to Lyme disease, a Pennsylvania federal judge on Feb. 1 denied the claimant's motion for summary judgment and granted the plan's motion for summary judgment (Elizabeth L. Ryan v. PNC Financial Services Group Inc., et al., No. 14-1048, W.D. Pa.; 2016 U.S. Dist. LEXIS 11518). (Source: LexisNexis® Mealey's™ Disability Insurance Legal News)


Wednesday 10 February 2016

Lyme Disease in Hispanics, United States, 2000–2013

C. Nelson et al. (Source: Emerging Infectious Diseases Journal)


Wednesday 10 February 2016

Tick tock -- sequencing the tick genome could help defuse the Lyme disease time bomb

(Swiss Institute of Bioinformatics) After a decade-long research effort the genome of the deer tick has been sequenced by an international team of scientists, including researchers from the SIB Swiss Institute of Bioinformatics. Studying the tick genome sheds light on how ticks function and will help to develop novel tick control programs by interfering with the processes of disease transmission. (Source: EurekAlert! - Biology)


Wednesday 10 February 2016

Eradication of Biofilm-Like Microcolony Structures of Borrelia burgdorferi by Daunomycin and Daptomycin but not Mitomycin C in Combination with Doxycycline and Cefuroxime

Jie Feng, Megan Weitner, Wanliang Shi, Shuo Zhang, Ying Zhang (Source: Frontiers in Microbiology)


Wednesday 10 February 2016

Unilateral sequential papillophlebitis and central retinal artery occlusion in a young healthy patient

Gülizar Demirok, Mehmet Fatih Kocamaz, Yasemin Topalak, Ahmet Sengün, Berati HasanreisogluIndian Journal of Ophthalmology 2015 63(12):921-924A 23-year-old girl presented to the clinic with metamorphopsia and photopsia in her left eye. After detailed ophthalmic examination, central retinal vein occlusion with optic disc edema was detected in that eye. Three days after diagnosis, the patient returned to our clinic with visual acuity decrease. Central retinal artery occlusion sparing cilioretinal artery was detected. All the laboratory tests were normal except for heterozygous methylenetetrahydrofolate reductase mutation (A1298C genotypes) and an indefinite Lyme disease seropositivity. Symptoms and visual disturbance recovered without any further treatment other than acetylsalic...


Wednesday 10 February 2016

Mayo Clinic Minute: Lyme Disease Discovery

Mayo Clinic researchers have discovered a new Lyme disease-causing organism that is capable of creating more intense symptoms. In this Mayo Clinic Minute, Jeff Olsen speaks with Dr. Bobbi Pritt, director of the Clinical Parasitology Laboratory at Mayo Clinic, about the new findings. Watch the Mayo Clinic Minute https://www.youtube.com/watch?v=r7TxQs4FIVs&feature=youtu.be Journalists: Broadcast quality video is available [...] (Source: News from Mayo Clinic)

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Tuesday 9 February 2016

New Bacteria That Causes Lyme Disease Discovered

Researchers from the Mayo Clinic and the CDC made the discovery. (Source: ABC News: Health)


Tuesday 9 February 2016

New species of bacteria causes Lyme disease in humans, scientists warn

The Centers for Disease Control and Prevention revealed a new bacteria also causes Lyme disease - with more severe symptoms, such as nausea and rash, than a previously found bacteria. (Source: the Mail online | Health)


Tuesday 9 February 2016

Taking Concussions Head-On: Part II

Recognizing the Breadth of the Problem and the Search for Answers Previously, I discussed the serious issue of concussions in sports - at all levels - and some of the efforts being pursued to combat it. Much is being done, but one simple and effective path bears further exploration. There may be reason to believe that the secret to diagnosing a concussion could reside in our saliva, offering for the first time an avenue to quickly and accurately provide a definitive diagnosis. Developing a Spit Test Long regarded as the sole domain of the dentist, the medical community in recent years has begun to recognize the mouth as a vital gateway to identifying and evaluating overall body wellness. One initiative helping to change this perception is the emergence of salivary diagnostics. Saliva, it...


Tuesday 9 February 2016

New Lyme Disease Bacteria Discovered: CDC

Infection may trigger nausea, vomiting and a more widespread rash, officials say (Source: WebMD Health)


Tuesday 9 February 2016

Scientists Discover New Bacteria Responsible For Lyme Disease

ATLANTA (Reuters) - Researchers have discovered a new bacteria that causes Lyme disease in humans, a U.S. health agency said Monday. The Centers for Disease Control and Prevention, working with the Mayo Clinic and health officials from Minnesota, Wisconsin and North Dakota, discovered the new bacteria, called Borrelia mayonii, the CDC said in a statement. Previously, only one bacteria, Borrelia burgdorferi, was believed to cause human Lyme disease, which is transmitted through bites from by the blacklegged "deer" tick, the CDC statement said. The new bacteria has so far only been detected in the upper Midwest region of the United States, the CDC said. Researchers discovered Borrelia mayonii after studying blood samples of patients in Minnesota, Wisconsin, and North Dakota who were suspecte...

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Tuesday 9 February 2016

New Lyme Disease Bacteria Discovered in Upper Midwest: CDC

Infection may trigger nausea, vomiting and a more widespread rash, officials say Source: HealthDay Related MedlinePlus Pages: Lyme Disease, Tick Bites (Source: MedlinePlus Health News)


Tuesday 9 February 2016

Medical News Today: New bacteria discovered that cause Lyme disease

Scientists have found new bacteria that cause Lyme disease. They produce symptoms similar to those of the known bacteria, but they also cause nausea, vomiting and diffuse rashes. (Source: Health News from Medical News Today)


Tuesday 9 February 2016

Scientists confirm second, more intense form of Lyme disease

Stephen FellerATLANTA, Feb. 9 (UPI) -- The CDC and Mayo Clinic confirmed a second species of bacteria causing Lyme disease in the upper Midwest area of the United States. (Source: Health News - UPI.com)


Tuesday 9 February 2016

New Lyme Disease Bacteria Discovered in Upper Midwest: CDC

TUESDAY, Feb. 9, 2016 -- A new Lyme disease-causing bacteria has been identified in the United States, and it may bring even worse symptoms, health officials said. Borrelia burgdorferi was the only bacteria species believed to cause Lyme disease in... (Source: Drugs.com - Daily MedNews)


Tuesday 9 February 2016

Scientists Found A New Bacteria Causing Lyme Disease: Borrelia Mayonii

There’s a new Borrelia bacterium on the block, joining its cousin in causing Lyme disease. B. mayonii has recently been identified as a new cause of Lyme in the Midwest. (Source: Forbes.com Healthcare News)

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Tuesday 9 February 2016

Studying Tick Biology With Lyme Prevention in Mind

TUESDAY, Feb. 9, 2016 -- Scientists who sequenced the genome, or genetic composition, of the Lyme disease-transmitting deer tick hope the achievement will lead to new ways to control the blood-sucking parasites. The decade-long effort involved an... (Source: Drugs.com - Daily MedNews)


Tuesday 9 February 2016

Tick genome reveals inner workings of a resilient blood-guzzler

(Purdue University) An international team of scientists led by Purdue University has sequenced the genome of the tick that transmits Lyme disease, the most common vector-borne illness in North America. (Source: EurekAlert! - Infectious and Emerging Diseases)


Tuesday 9 February 2016

Lyme disease just got nastier

Until now, scientists thought only one species of bacteria was responsible for the tick-borne Lyme disease (Source: Health News: CBSNews.com)


Tuesday 9 February 2016

Pilot Cross-Sectional Study of Three Zoonoses (Lyme Disease, Tularaemia, Leptospirosis) among Healthy Blood Donors in Eastern Slovakia.

CONCLUSIONS: ELPAGA seroprevalence for TUL was significantly higher in blood donors working in the agricultural area in the direct contact with hay, straw, manure, and agricultural land. Our outputs determine tick bite as a significant risk factor for LB. The study confirms the explosion of tick-borne diseases in the healthy population of people. The exposure risk for leptospirosis seems to be minimal. PMID: 26851418 [PubMed - as supplied by publisher] (Source: Central European Journal of Public Health)


Tuesday 9 February 2016

Changes in the Proteome of Langat-Infected Ixodes scapularis ISE6 Cells: Metabolic Pathways Associated with Flavivirus Infection

Conclusions/Significance Proteomic analyses revealed ISE6 proteins that were differentially expressed at the peak of LGTV replication. Proteins with increased expression following infection were associated with cellular metabolic pathways and glutaminolysis. In vitro assays using small molecules implicate malate dehydrogenase (MDH2), the citrate cycle, cellular acetylation, and electron transport chain processes in viral replication. Proteins were identified that may be required for TBF infection of ISE6 cells. These proteins are candidates for functional studies and targets for the development of transmission-blocking vaccines and drugs. (Source: PLoS Neglected Tropical Diseases)

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Tuesday 9 February 2016

New Bacteria Species that Causes Lyme Disease Discovered (FREE)

By Kelly Young Edited by Jaye Elizabeth Hefner, MD Scientists report the discovery of a new species of bacteria (Borrelia mayonii) in the upper Midwest of the U.S. that causes a unique presentation of Lyme disease. Their findings appear in the Lancet Infectious Diseases.Researchers screened … (Source: Physician's First Watch current issue)


Monday 8 February 2016

Researchers identify new Borrelia species that causes Lyme disease

A new bacterial species that causes Lyme disease in people has been identified by researchers. The new species has been provisionally named Borrelia mayonii. Prior to this finding, the only species believed to cause Lyme disease in North America was Borrelia burgdorferi. (Source: ScienceDaily Headlines)

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Monday 8 February 2016

Mayo researchers identify new Borrelia species that causes Lyme disease

(Mayo Clinic) Mayo Clinic researchers, in collaboration with the Centers for Disease Control and Prevention (CDC) and health officials from Minnesota, North Dakota and Wisconsin, have discovered a new bacterial species that causes Lyme disease in people. The new species has been provisionally named Borrelia mayonii. Prior to this finding, the only species believed to cause Lyme disease in North America was Borrelia burgdorferi. (Source: EurekAlert! - Medicine and Health)


Monday 8 February 2016

Diagnostic Value of Recombinant Tp0821 Protein in Serodiagnosis for Syphilis

This article is protected by copyright. All rights reserved. (Source: Letters in Applied Microbiology)


Monday 8 February 2016

Mayo Researchers Identify New Borrelia Species that Causes Lyme Disease

Until now, Borrelia burgdorferi was only species believed to cause Lyme disease in North America Rochester, Minn. — Mayo Clinic researchers, in collaboration with the Centers for Disease Control and Prevention (CDC) and health officials from Minnesota, North Dakota and Wisconsin, have discovered a new bacterial species that causes Lyme disease in people. The new [...] (Source: Mayo Clinic Minnesota News)


Sunday 7 February 2016

Mapping human risk of infection with Borrelia burgdorferi sensu lato, the agent of Lyme borreliosis, in a periurban forest in France

The objective of our study was to provide a snapshot map of the risk of human infection with B. burgdorferi s. l. pathogens in a periurban forest at a high resolution, and to analyze the factors that contribute to variation in this risk. Field monitoring took place over three weeks in May 2011 in the suburban Sénart forest (3,200ha; southeast of Paris), which receives over 3 million people annually. We sampled ticks over the entire forest area (from 220 forest stands with a total area of 35,200 m2) and quantified the density of questing nymphs (DON), the prevalence of infection among nymphs (NIP), and the density of infected nymphs (DIN), which is the most important predictor of the human risk of Lyme borreliosis. For each of these response variables, we explored the relative roles of wea...


Friday 5 February 2016

Targeting Lyme disease

Did you know that deer ticks can live for up to 2 years and are able to survive in the winter? During the winter months, ticks can be active when temperatures increase to 35° F or higher. Learn how to protect your patients year round. (Source: Nursing Made Incredibly Easy)


Friday 5 February 2016

[Winged scapula in lyme borreliosis].

Authors: Rausch V, Königshausen M, Gessmann J, Schildhauer TA, Seybold D Abstract Here we present the case of a young patient with one-sided winged scapula and lyme borreliosis. This disease can be very delimitating in daily life. If non-operative treatment fails, dynamic or static stabilization of the scapula can be a therapeutic option. PMID: 26849378 [PubMed - as supplied by publisher] (Source: Der Orthopade)

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Thursday 4 February 2016

[Comment] Detection of a novel Lyme borreliosis pathogen

Ticks are vectors of many pathogens of human beings, wildlife, and livestock. Several tick-borne pathogens pose serious threats to public and animal health and cause substantial economic loss.1 Lyme borreliosis, the most common tick-borne disease in the northern hemisphere, is caused by spirochaetes that belong to a group of genospecies called Borrelia burgdorferi sensu lato.2 (Source: The Lancet Infectious Diseases)


Thursday 4 February 2016

[Articles] Identification of a novel pathogenic Borrelia species causing Lyme borreliosis with unusually high spirochaetaemia: a descriptive study

We describe a new pathogenic Borrelia burgdorferi sensu lato genospecies (candidatus Borrelia mayonii) in the upper midwestern USA, which causes Lyme borreliosis with unusually high spirochaetaemia. Clinicians should be aware of this new B burgdorferi sensu lato genospecies, its distinct clinical features, and the usefulness of oppA1 PCR for diagnosis. (Source: The Lancet Infectious Diseases)


Thursday 4 February 2016

How 11 Top NYC Doctors Missed My Lyme Disease

A July 2014 wedding on Long Beach Island, New Jersey was the start of my nightmare. It was a beautiful weekend filled with love for two of our dearest friends who were, after 14 years together, finally legally able to marry. There was lobster and champagne and a crazy Gordon Gekko-style house on the beach. I sang a few songs, made a toast, and cried happy tears. I woke up two days later, back home in NYC, with a crushing head and neck ache. It was weird, but I figured I would sleep it off and be better in the morning. It took a few days, but I recovered. That Saturday, I got out of the shower and saw a faint red circular rash on my shoulder with a bug bite in the middle. My knees buckled. I called for my husband, Andy, "HUNNEEEE! I have LYME!" He really didn't think so. I banged on my...


Thursday 4 February 2016

Early Detection of Autism (ASD) by a Non-invasive Quick Measurement of Markedly Reduced Acetylcholine & DHEA and Increased β-Amyloid (1-42), Asbestos (Chrysotile), Titanium Dioxide, Al, Hg & often Coexisting Virus Infections (CMV, HPV 16 and 18), Bacterial Infections etc. in the Brain and Corresponding Safe Individualized Effective Treatment.

Authors: Omura Y, Lu D, Jones MK, Nihrane A, Duvvi H, Shimotsuura Y, Ohki M Abstract A brief historical background on Autism & some of the important symptoms associated with Autism are summarized. Using strong Electro Magnetic Field Resonance Phenomenon between 2 identical molecules with identical weight (which received U.S. Patent) non-invasively & rapidly we can detect various molecules including neurotransmitters, bacteria, virus, fungus, metals & abnormal molecules. Simple non- invasive measurement of various molecules through pupils & head of diagnosed or suspected Autism patients indicated that in Autism patients following changes were often found: 1) Acetylcholine is markedly reduced; 2) Alzheimer's disease markers (i.e. β-Amyloid (1-42), Tau Protein, Apolip...


Wednesday 3 February 2016

What the rise of Zika (and other viruses) might tell us about our planet

Follow me at @JohnRossMD Zika virus, a pathogen that was almost unknown a few months ago, is now rampant in Central and South America and the Caribbean. In Brazil, it has already infected about 1.5 million people and caused nearly 4,000 cases of microcephaly, a severe birth defect. It is almost certain to spread to every country in the Americas, except Canada and Chile, which lack the Aedes mosquitoes that spread Zika. Zika is not the only virus that has come from the tropics to menace the United States. Dengue, an unpleasant and potentially fatal viral infection, has broken out in Texas, Florida and Hawaii in the past 10 years. Chikungunya, a virus that can cause prolonged joint pain and ruin your vacation, has caused recent outbreaks in Florida, Puerto Rico and the U.S. Virgin Islands. A...


Monday 1 February 2016

Why Are We Seeing an Explosion of New Viruses Like Zika?

Zika virus, Ebola, Middle East Respiratory Syndrome (MERS) coronavirus, Severe Acute Respiratory Syndrome (SARS) coronavirus, Nipah virus, Hendra virus, bird flu, swine flu -- these viruses have all grabbed international attention in recent years. In the past few decades the world has witnessed an alarming surge in emerging infectious diseases (EIDs). Since 1980, new pathogens have emerged in the human population at a rate of about three each year. Why are we seeing such a surge in new pathogens? One could argue that some of the pathogens may not be new at all; they could have circulated among humans for centuries and are just being identified for the first time because of increased surveillance and reporting. While this is true in a small number of cases, a study found that even after co...

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Friday 29 January 2016

Cell-free Expression of MraY Homologues and Mur Enzymes [Enzymology]

We report the efficient production of MraY homologues from various human pathogens by synthetic cell-free expression approaches and their subsequent characterization. MraY homologues originating from Bordetella pertussis, Helicobacter pylori, Chlamydia pneumoniae, Borrelia burgdorferi, and Escherichia coli as well as Bacillus subtilis were co-translationally solubilized using either detergent micelles or preformed nanodiscs assembled with defined membranes. All MraY enzymes originating from Gram-negative bacteria were sensitive to detergents and required nanodiscs containing negatively charged lipids for obtaining a stable and functionally folded conformation. In contrast, the Gram-positive B. subtilis MraY not only tolerates detergent but is also less specific for its lipid environment. T...


Wednesday 27 January 2016

New way to detect human-animal diseases tested in lemurs

(Duke University) RNA sequencing is uncovering emerging diseases in wildlife that other diagnostic tests cannot detect. Researchers used a technique called transcriptome sequencing to screen for blood-borne diseases in Madagascar's lemurs, distant primate cousins to humans. The animals were found to be carrying several previously unknown parasites similar to those that cause Lyme disease in humans. The approach could pave the way for earlier, more accurate detection of disease outbreaks that move between animals and people. (Source: EurekAlert! - Biology)


Wednesday 27 January 2016

Next Generation Sequencing Reveals Restriction and Clonotypic Expansion of Regulatory T Cells in Juvenile Idiopathic Arthritis

Conclusions: Our data identified restriction and clonotypic expansions in the JIA Treg repertoire with sharing of Treg clonotypes across arthritis patients. These findings suggest that abnormalities in the Treg repertoire, possibly engendered by shared antigenic triggers, may contribute to disease pathogenesis in JIA. This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)

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Tuesday 26 January 2016

Emma Horlock with Lyme disease forced to spend 22 HOURS a day in bed

Emma Horlock, 41, from Liverpool, thought she had MS when she found herself struggling to walk. But when tests came back negative, a laboratory in Germany found she had Lyme disease. (Source: the Mail online | Health)


Sunday 24 January 2016

Tick iron and heme metabolism – New target for an anti-tick intervention

Publication date: Available online 18 January 2016 Source:Ticks and Tick-borne Diseases Author(s): Ondrej Hajdusek, Radek Sima, Jan Perner, Gabriela Loosova, Adela Harcubova, Petr Kopacek Ticks are blood-feeding parasites and vectors of serious human and animal diseases. Ixodes ricinus is a common tick in Europe, transmitting tick-borne encephalitis, Lyme borreliosis, anaplasmosis, or babesiosis. Immunization of hosts with recombinant tick proteins has, in theory, the potential to interfere with tick feeding and block transmission of pathogens from the tick to the host. However, the efficacy of tick antigens has, to date, not been fully sufficient to achieve this. We have focused on 11 in silico identified genes encoding proteins potentially involved in tick iron and heme metabolis...


Friday 22 January 2016

Treat Lyme disease naturally without toxic antibiotic drugs

(NaturalNews) Lyme disease is a common, yet serious, problem for many regions of the United States. The Centers for Disease Control (CDC) reports that about 30,000 cases of Lyme disease are documented by state health departments each year, with countless others going undiagnosed and... (Source: NaturalNews.com)


Friday 22 January 2016

First Molecular Evidence of Zoonotic Bacteria in Ticks in Bosnia and Herzegovina

This study reports the occurrence of emerging zoonotic bacteria in ticks from Bosnia and Herzegovina for the first time, indicating a public health threat to humans. Therefore, physicians and practitioners should be aware of the presence of these tick‐borne bacteria, especially when they are faced with acute febrile illnesses after tick exposure. (Source: Transboundary and Emerging Diseases)


Friday 22 January 2016

IgA nephropathy and infections.

Authors: Rollino C, Vischini G, Coppo R Abstract In this paper we concentrate on the role of infections in IgA nephropathy both from a pathogenetic and clinic point of view. The current hypotheses as regards the role of infections in the pathogenesis of IgA nephropathy are: (a) role of particular pathogens, (b) chronic exposure to mucosal infections, (c) abnormal handling of commensal microbes (gut microbiota). We also focus on particular infections reported in association with classic IgA nephropathy (HIV, malaria, Chlamydia, Lyme disease), as well as on IgA dominant-infection-associated glomerulonephritis. This is a unique form of glomerulonephritis, where IgA deposition is dominant. It is mostly recognized in old, diabetic patients and in association with staphylococcal infectio...


Friday 22 January 2016

Lyme Disease

Occupational and environmental health nurses should educate workers about ways to prevent tick bites, which can cause Lyme disease. (Source: Workplace Health and Safety)


Thursday 21 January 2016

Ticks carrying Lyme disease found in half of U.S. counties

Stephen FellerATLANTA, Jan. 21 (UPI) -- Ticks carrying Lyme disease can now be found in half of counties in the United States, a significant increase over the last two decades. (Source: Health News - UPI.com)


Wednesday 20 January 2016

An Australian guideline on the diagnosis of overseas-acquired Lyme disease/borreliosis.

Authors: Lum GD, Hood JR, Wright P PMID: 26779732 [PubMed - in process] (Source: Communicable Diseases Intelligence Quarterly Report)

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Tuesday 19 January 2016

Lyme Disease Ticks Reported in Nearly 50% of All US Counties

Lyme disease is transmitted by the blacklegged tick (Ixodes scapularis) and the western blacklegged tick (Ixodes pacificus), and the range of these ticks is spreading, according to research published in the Journal of Medical Entomology. (Source: Disabled World)

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Tuesday 19 January 2016

Blacklegged Ticks Found in Half of U.S. Counties

Annapolis, MD; January 19, 2016 -- Lyme disease is transmitted by the blacklegged tick (Ixodes scapularis) and the western blacklegged tick (Ixodes pacificus), and the range of these ticks is spreading, according to research published in the Journal of Medical Entomology. read more (Source: ESA News)


Monday 18 January 2016

Lyme-Causing Ticks Expand Their Range in U.S.

Residents in nearly half of all counties now at risk, CDC says (Source: WebMD Health)


Monday 18 January 2016

Ticks carrying Lyme disease in almost half of U.S. counties

(Reuters Health) - Ticks that can spread Lyme disease now live in almost half of U.S. counties, according to a new study from the Centers for Disease Control and Prevention. (Source: Reuters: Health)


Monday 18 January 2016

Ticks that transmit Lyme disease reported in nearly half of all US counties

Lyme disease is transmitted by the blacklegged tick (Ixodes scapularis) and the western blacklegged tick (Ixodes pacificus), and the range of these ticks is spreading, according to new research. (Source: ScienceDaily Headlines)


Monday 18 January 2016

Woman told for 12 YEARS her insomnia, tiredness and dizzy spells were due to depression discovers her body is ravaged with Lyme disease 

Vanessa Boyd, 28, of Dronfield, Derbyshire, began experiencing bizarre symptoms from the age of 16 and claims she saw at least 30 different health professionals. (Source: the Mail online | Health)

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Monday 18 January 2016

Ticks that carry Lyme Disease live in almost half of US counties – study

Black-legged tick inhabits twice as many counties as in 1998, CDC reports, with 320% increase in number of north-eastern counties seen as high risk for diseaseTicks that can carry the debilitating illness Lyme disease have significantly spread across the US over the past 20 years and are now found in nearly half of all American counties, including areas where they’ve never previously been documented, a new analysis has found. The black-legged tick is now established in twice the number of counties it inhabited in 1998, according to the US Centers for Disease Control, and has expanded its range in the northeastern states and the upper midwest. Following its onward march, or hop, across the Ohio river valley, western New York and the shores of Lake Michigan since the 1990s, there has been ...


Monday 18 January 2016

Ticks that transmit Lyme disease reported in nearly half of all US counties

(Entomological Society of America) Lyme disease is transmitted by the blacklegged tick (Ixodes scapularis) and the western blacklegged tick (Ixodes pacificus), and the range of these ticks is spreading, according to research published in the Journal of Medical Entomology. (Source: EurekAlert! - Social and Behavioral Science)


Monday 18 January 2016

Tick iron and heme metabolism - new target for an anti-tick intervention

Publication date: Available online 18 January 2016 Source:Ticks and Tick-borne Diseases Author(s): Ondrej Hajdusek, Radek Sima, Jan Perner, Gabriela Loosova, Adela Harcubova, Petr Kopacek Ticks are blood-feeding parasites and vectors of serious human and animal diseases. Ixodes ricinus is a common tick in Europe, transmitting tick-borne encephalitis, Lyme disease (borreliosis), anaplasmosis, or babesiosis. Immunization of hosts with recombinant tick proteins has, in theory, the potential to interfere with tick feeding and block transmission of pathogens from the tick to the host. However, the efficacy of tick antigens has, to date, not been fully sufficient to achieve this. We have focused on 11 in silico identified genes encoding proteins potentially involved in tick iron and heme...


Friday 15 January 2016

Multiple Pathogens Including Potential New Species in Tick Vectors in Côte d’Ivoire

Conclusions/Significance For the first time, we demonstrate the presence of different pathogens such as R. aeschlimannii, C. burnetii, Borrelia sp., A. centrale, A. marginale, and E. ruminantium in ticks in Côte d’Ivoire as well as potential new species of unknown pathogenicity. (Source: PLoS Neglected Tropical Diseases)


Thursday 14 January 2016

Management approaches for suspected and established Lyme disease used at the Lyme disease diagnostic center.

Authors: Wormser GP, McKenna D, Nowakowski J Abstract 2015 marks the 27th year that the Lyme Disease Diagnostic Center, located in New York State in the United States, has provided care for patients with suspected or established deer tick-transmitted infections. There are five deer tick-transmitted infectious in this geographic area of which Lyme disease is the most common.For patients with erythema migrans, we do not obtain any laboratory testing. However, if the patient is febrile at the time of the visit or reports rigors and high-grade fevers, we consider the possibility of a co-infection and order pertinent laboratory tests.Our preferred management for Lyme disease-related facial palsy and/or radiculopathy is a 2-week course of doxycycline. Patients who are hospitalized for Ly...


Wednesday 13 January 2016

Third-degree heart block as initial presentation of Lyme disease.

Authors: Shah P, Mithawala P, Bajaj S, Virk H, Bikkina M PMID: 26717231 [PubMed - in process] (Source: Acta Cardiologica)

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Tuesday 12 January 2016

Vector-Borne Diseases in Stray Dogs in Peninsular Malaysia and Molecular Detection of Anaplasma and Ehrlichia spp. from Rhipicephalus sanguineus (Acari: Ixodidae) Ticks

This study was designed to determine the occurrence of vector-borne pathogens in Malaysian stray dogs using serological and molecular approaches. In total, 48 dog blood samples were subjected to serological analysis using SNAP 4Dx kit (IDEXX Laboratories, Westbrook, ME). The presence of Ehrlichia and Anaplasma DNA in the dog blood samples and Rhipicephalus sanguineus (Latreille) ticks was detected using nested polymerase chain reaction assays. Positive serological findings against Ehrlichia canis and Anaplasma phagocytophilum were obtained in 17 (39.5%) and four (9.3%) of 43 dog samples, respectively. None of the dog blood samples were positive for Borrelia burgdorferi and Dirofilaria immitis. DNA of E. canis and A. phagocytophilum was detected in 12 (25.5%) and two (4.3%) of 47 dog blood ...


Monday 11 January 2016

Man Diagnosed With ALS Dies of Lyme Disease (Part 1 of 2)

Tara and David Geraghty On Dec. 22, three days before Christmas, 55-year-old David A. Geraghty died from complications of a supposedly rarely fatal infection: Lyme disease. As reported in The Valley Breeze, a Lincoln, R.I. newspaper, Geraghty and his family found out conclusively that he has had Lyme disease just one year ago, last December. As was the case for me and is not uncommon in other cases of Lyme disease diagnoses, it was Geraghty and his wife -- not his physicians -- who pushed for investigation into the cause of his illness and ultimately were responsible for discovering that Lyme disease was at the root. Geraghty was diagnosed in 2013 with ALS, a degenerative and usually fatal neuromuscular disease. (ALS was briefly raised as a potential cause of my most severe symptoms years ...


Saturday 9 January 2016

Expanding the clinicopathological spectrum of late cutaneous Lyme borreliosis (acrodermatitis chronica atrophicans [ACA]): A prospective study of 20 culture- and/or polymerase chain reaction (PCR)-documented cases

The diagnosis of acrodermatitis chronica atrophicans (ACA), the late cutaneous manifestation of Lyme borreliosis, can be challenging. Histologic changes in ACA have been described in a few studies from endemic countries, relying on cases documented by serology only. (Source: Journal of the American Academy of Dermatology)


Wednesday 6 January 2016

Lyme Neuroborreliosis: A Potentially Preventable Cause of Stroke

A 15-year-old boy presented with multiple cranial nerve palsies including bilateral facial nerve palsy, right-sided limb weakness, and cerebellar signs. Nine months previously, after a trip to the Scottish Highlands where he reported a discrete scalp rash, he began experiencing lethargy, anorexia, arthromyalgia, and headache. He attended his general practitioner 4 months into the course of this illness and was treated with a short course of oral azithromycin, following which symptoms transiently improved. (Source: The Journal of Pediatrics)


Wednesday 6 January 2016

Lyme disease-related intracranial hypertension in children: clinical and imaging findings

The objective of this study is to evaluate the history, clinical findings, CSF analysis, and brain imaging results in pediatric patients with increased intracranial pressure secondary to LD. A retrospective database search was performed using the International Classification of Diseases (ICD) 9/10 codes to identify patients diagnosed with LD and IH between 2004 and 2014 at a tertiary referral pediatric hospital. Clinical, laboratory and neuroimaging data for each patient were reviewed. Seven patients met inclusion criteria; mean age was 9.6 years (standard deviation 4.0 years); 4/7 patients were male. Average body mass index was 18.8 kg/m2 (standard deviation 3.0 kg/m2). Fever was present in four patients. Four had a history of LD related erythema migrans. All had elevated CSF opening ...


Tuesday 5 January 2016

Bitten: A Patient With Tickborne Disease Struggles To Find The Right Provider [Narrative Matters]

For a patient with Lyme disease–like symptoms, the biggest challenge is finding a specialist who understands her condition. (Source: Health Affairs)

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Sunday 27 December 2015

Parry-Romberg syndrome: a case with a possible association with Lyme disease.

Authors: di Meo N, Stinco G, Nan K, Pinzani C, Trevisan G Abstract Parry-Romberg syndrome is an acquired slowly progressive disease characterized by an atrophy mostly involving half of the face. The pathogenesis of this disfiguring condition is still controversial. The relationship between Parry-Romberg syndrome and Lyme disease needs to be considered in depth. A 16-year-old woman from Albania presented with linear depressions of the right side of the face, clinically compatible with Parry-Romberg syndrome. She had a positive history of Lyme disease. Borrelia infection was confirmed by the positivity of PCR and the presence of IgM antibodies. The patient received intravenous penicillin and metronidazole for 14 days. After treatment and during a 2-year follow-up, the clinical diseas...


Friday 25 December 2015

Christmas, Grief, and Moving Forward After an Alzheimer's Diagnosis

The last time my mother and I stood near a Christmas tree together was December 2012. She was in the middle of a long battle with Chronic Lyme Disease and we had recently found out that she also had Alzheimer's. This dynamic cocktail of ailments left her unable to function as she used to -- as an entertainer, caregiver, and a joker. My mother and I were very close, and when she began showing signs of her disease I became extremely protective of her. A little more than 10 years prior my mother was very protective of me as I successfully battled Stage 3 Hodgkin's Disease -- cancer. This created a unique bond that seems to have literally given me the ability to feel her pain, shame and exhaustion. The Christmas season is my favorite time of year. Mainly because of all the amazing memories I ...


Wednesday 23 December 2015

Anti-inflammatory effects of dexamethasone and meloxicam on Borrelia burgdorferi-induced inflammation in neuronal cultures of dorsal root ganglia and myelinating cells of the peripheral nervous system

Conclusions: These data help further explain our in vivo findings of significantly reduced levels of inflammatory mediators, DRG-apoptosis, and lack of inflammatory neurodegenerative lesions in the nerve roots and DRG of Bb-infected animals that were treated with dexamethasone, but not meloxicam. Evaluating the role of the signaling mechanisms that contribute to the anti-inflammatory potential of dexamethasone in the context of LNB could serve to identify therapeutic targets for limiting radiculitis and axonal degeneration in peripheral LNB. (Source: Journal of Neuroinflammation)


Tuesday 22 December 2015

Postepy Hig Med Dosw 2015; 69:1222-1227 "Analysis of nanomechanical properties of Borrelia burgdorferi spirochetes under the influence of lytic factors in an in vitro model using atomic force microscopy"

Conclusion: The average value of flexibility of spirochetes’ surface expressed by Young’s modulus was 10185.32 MPa, whereas the adhesion force was 3.68 nN. AFM is a modern tool with a broad spectrum of observational and measurement abilities. Young’s modulus and the adhesion force can be treated as parameters in the evaluation of intensity and changes which take place in pathogenic microorganisms under the influence of various lytic factors. The visualization of the changes in association with nanomechanical features provides a realistic portrayal of the lytic abilities of the elements of the innate and adaptive human immune system. (Source: Postepy higieny i medycyny doswiadczalnej)


Tuesday 22 December 2015

Prevalence of Borrelia miyamotoi in Ixodes persulcatus in Irkutsk City and its neighboring territories, Russia

Publication date: Available online 21 December 2015 Source:Ticks and Tick-borne Diseases Author(s): Maxim A. Khasnatinov, Galina A. Danchinova, Ai Takano, Hiroki Kawabata, Norio Ohashi, Toshiyuki Masuzawa Adult Ixodes persulcatus were collected in highly populated districts in Irkutsk city, Russia, and/or in popular recreational and professional areas in its neighboring territories. Borrelia miyamotoi infection in I. persulcatus was examined using multiplex Taqman-PCR targeting 16S rDNA, and nested PCR and sequencing analyses targeting flaB and 16S rDNA. B. miyamotoi and Lyme disease Borrelia species were detected in 13 (infection rate, 2.9%) and 77 (17.3%) out of 445 I. persulcatus ticks, respectively, collected from 4 sites around the Baikal Lake. The 16S rDNA and flaB sequences ...


Monday 21 December 2015

Distribution and survival of Borrelia miyamotoi in human blood components.

CONCLUSIONS: This study demonstrated that B. miyamotoi can survive standard storage conditions of most human blood components, suggesting the possibility of transmission by blood transfusion. PMID: 26689144 [PubMed - as supplied by publisher] (Source: Transfusion)

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Sunday 20 December 2015

Lyme Borreliosis: Is there a preexisting (natural) variation in antimicrobial susceptibility among Borrelia burgdorferi strains?

Authors: Hodzic E Abstract The development of antibiotics changed the world of medicine and has saved countless human and animal lives. Bacterial resistance/tolerance to antibiotics have spread silently across the world and has emerged as a major public health concern. The recent emergence of pan-resistant bacteria can overcome virtually any antibiotic and poses a major problem for their successful control. Selection for antibiotic resistance may take place where an antibiotic is present: in the skin, gut, and other tissues of humans and animals and in the environment. Borrelia burgdorferi, the etiological agents of Lyme borreliosis, evades host immunity and establishes persistent infections in its mammalian hosts. The persistent infection poses a challenge to the effective antibi...


Friday 18 December 2015

Serological and molecular evidence for Spotted Fever Group Rickettsia and Borrelia burgdorferi sensu lato co-infections in the Netherlands

In conclusion, our data show that B. burgdorferi s.l. and SFG rickettsiae co-infection occurs in Dutch I. ricinus and that Lyme borreliosis patients, or patients suspected of Lyme borreliosis, are indeed exposed to both tick-borne pathogens. Whether SFG rickettsiae actually cause disease, and whether co-infections alter the clinical course of Lyme borreliosis, is not clear from our data, and warrants further investigation. (Source: Ticks and Tick borne Diseases)


Friday 18 December 2015

Multi-trophic interactions driving the transmission cycle of Borrelia afzelii between Ixodes ricinus and rodents: a review

The tick Ixodes ricinus is the main vector of the spirochaete Borrelia burgdorferi sensu lato, the causal agent of Lyme borreliosis, in the western Palearctic. Rodents are the reservoir host of B. afzelii, which can be transmitted to I. ricinus larvae during a blood meal. The infected engorged larvae moult into infected nymphs, which can transmit the spirochaetes to rodents and humans. Interestingly, even though only about 1 % of the larvae develop into a borreliae-infected nymph, the enzootic borreliae lifecycle can persist. The development from larva to infected nymph is a key aspect in this lifecycle, influencing the density of infected nymphs and thereby Lyme borreliosis risk. The density of infected nymphs varies temporally and geographically and is influenced by multi-trophic (tick-...


Friday 18 December 2015

Impact of Spring Bird Migration on the Range Expansion of Ixodes scapularis Tick Population.

In this study, we develop a periodic delay meta-population model which takes into consideration the local landscape for tick reproduction within patches and the times needed for ticks to be transported by birds between patches. Assuming that the tick population is endemic in the source region, we find that bird migration may boost an already established tick population at the subsequent region and thus increase the risk to humans, or bird migration may help ticks to establish in a region where the local landscape is not appropriate for ticks to survive in the absence of bird migration, imposing risks to public health. This theoretical study reveals that bird migration plays an important role in the geographic range expansion of I. scapularis, and therefore our findings may suggest some str...


Thursday 17 December 2015

Will Culling White ‐Tailed Deer Prevent Lyme Disease?

Summary White‐tailed deer play an important role in the ecology of Lyme disease. In the United States, where the incidence and geographic range of Lyme disease continue to increase, reduction of white‐tailed deer populations has been proposed as a means of preventing human illness. The effectiveness of this politically sensitive prevention method is poorly understood. We summarize and evaluate available evidence regarding the effect of deer reduction on vector tick abundance and human disease incidence. Elimination of deer from islands and other isolated settings can have a substantial impact on the reproduction of blacklegged ticks, while reduction short of complete elimination has yielded mixed results. To date, most studies have been conducted in ecologic situations that are not rep...

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Thursday 17 December 2015

Infectious aetiology of marginal zone lymphoma and role of anti-infective therapy

Marginal zone lymphomas have been associated with several infectious agents covering both viral and bacterial pathogens and in some cases a clear aetiological role has been established. Pathogenetic mechanisms are currently not completely understood, however the role of chronic stimulation of the host immune response with persistent lymphocyte activation represents the most convincing explanation for lymphoproliferation. Gastric MALT lymphoma is strictly associated with Helicobacter pylori infection and various eradicating protocols, developed due to increasing antibiotic resistance, represent the first line therapy. The response rate to eradication is good with 80% of response at 1 year; this finding is also noteworthy because recapitulates a cancer cured only by antibacterial approach an...


Wednesday 16 December 2015

The generalist tick Ixodes ricinus and the specialist tick Ixodes trianguliceps on shrews and rodents in a northern forest ecosystem– a role of body size even among small hosts

Conclusions: Body mass was important for explaining load of I. ricinus mainly up to a body mass of ~10 g across a range of smaller mammalian hosts. Consistent with earlier work elsewhere in Europe, we found the highest tick infestation intensity on the wood mouse A. sylvaticus. However, this rodent species fed only 20.4 % of all I. ricinus larvae, while the much more abundant S. araneus fed 61.9 %. Our study emphasizes an important quantitative role of the common shrew S. araneus as a main host to I. ricinus larvae and to both I. trianguliceps larvae and nymphs. The partly seasonal distinct attachment pattern of I. ricinus and I. trianguliceps is evidence for niche separation. (Source: Parasites and Vectors)


Monday 14 December 2015

Ben Baddeley desperate to walk made Christmas cards with his FEET to pay for physio

Ben Baddeley, 11, of Newcastle-under-Lyme, Staffordshire, is learning to walk unaided for the first time since having an operation to relieve muscle spasms caused by cerebral palsy. (Source: the Mail online | Health)

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Monday 14 December 2015

How to beat Lyme disease and keep enjoying the great outdoors

A surge in cases of the tick-borne infection Lyme disease has made some people wary of the countryside. But there’s no need to worry, if you take care‘To be honest,” enthuses Dr Tim Brooks, “it’s a fascinating disease.” As head of the Rare and Imported Pathogens laboratory at Public Health England, trying to solve the growing problem of Lyme disease (and other bugs, such as ebola) is his vocation. Lyme disease – a bacterial infection spread by infected ticks – is a particularly complex puzzle, with little reliable data available so far. It can appear in numerous forms, occasionally causing long-term neurological symptoms that could be mistaken for other conditions, such as multiple sclerosis or motor neurone disease.Following a surge in cases this year – th...


Monday 14 December 2015

"Lyme": Chronic Fatigue Syndrome by Another Name?

(Source: Clinical Infectious Diseases)


Sunday 13 December 2015

Isolation and characterization of Borrelia burgdorferi strains from Ixodes ricinus ticks in the southern England.

CONCLUSION: As a result of this study, antigenic differences have been seen between the UK isolates and the foreign isolates used as laboratory standards. PMID: 26191500 [PubMed] (Source: BioImpacts)


Saturday 12 December 2015

Clinical and diagnosis considerations of Lyme disease.

Authors: Ionescu D, Cotar AI, Bădescu D, Dumitriu S PMID: 24187811 [PubMed - indexed for MEDLINE] (Source: Roumanian Archives of Microbiology and Immunology)

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Saturday 12 December 2015

[Evaluation of 10 cases of Lyme disease presenting with erythema migrans in Istanbul, Turkey].

Authors: Akın Belli A, Derviş E, Özbaş Gök S, Midilli K, Gargılı A Abstract Lyme disease (LD) is a tick-borne, multisystemic infection caused by Borrelia burgdorferi. Although variable rates of seropositivity for B.burgdorferi have been reported between 2% to 44% in Turkey, its actual prevalence is not well-understood. The aim of this retrospective study was to evaluate the characteristics of 10 cases of LD presenting as erythema migrans (EM) between 2009 and 2013 from Istanbul which is one of the metropolitan cities of Turkey. Of the patients, five were male and five were female, ages between 9-51 years (mean age: 34.5 years). Five of the patients were admitted in June, three in October, one in November and two in December and all have the history of tick bite in last 1-2 w...


Friday 11 December 2015

Comparison of detection of Borrelia burgdorferi DNA and anti-Borrelia burgdorferi antibodies in patients with erythema migrans in north-eastern Poland.

CONCLUSIONS: Polymerase chain reaction of skin biopsy specimens seems to be currently the most sensitive and specific test for the diagnosis of patients with EM, especially in patients with a short duration of the disease (< 14 days) but still its effectiveness is much lower than expected. Polymerase chain reaction of blood samples cannot be recommended at the present time for the routine diagnostic of patients with EM. PMID: 25821421 [PubMed] (Source: Advances in Dermatology and Allergology)


Friday 11 December 2015

Sequential insults: acute Lyme disease with splenic infarction

After appropriate treatment was started for a patient’s most likely diagnosis, a surprising new finding prompted reevaluation. Previously healthy, the 39-year-old-man presented to his primary care clinic in early October after 7 days of progressive lower extremity myalgias, malaise, intermittent fevers, generalized headaches, rigors, and night sweats. He had no upper respiratory symptoms, abdominal pain, dysuria, diarrhea, rash, or arthralgias. (Source: The American Journal of Medicine)



Wednesday 9 December 2015

Natural foci of Borrelia lusitaniae in a mountain region of Central Europe

Publication date: Available online 9 December 2015 Source:Ticks and Tick-borne Diseases Author(s): Veronika Rusňáková Tarageľová, Lenka Mahríková, Diana Selyemová, Radovan Václav, Markéta Derdáková Lyme borreliosis is the most prevalent tick-borne disease in Europe. It is caused by spirochaetes of the Borrelia burgdorferi sensu lato (s.l.) complex and transmitted to humans by ticks of the genus Ixodes. B. afzelii, B. garinii, and B. valaisiana are the most common genospecies in Central Europe. In contrast, B. lusitaniae predominates in Mediterranean countries such as Portugal, Morocco, and Tunisia. In Slovakia, its prevalence is low and restricted to only a few sites. The aim of our research was to study the expansion of ticks into higher altitudes in the ecosystem of th...



Monday 7 December 2015

Tick-Borne Disease Preventive Practices and Perceptions in an Endemic Area

Publication date: Available online 7 December 2015 Source:Ticks and Tick-borne Diseases Author(s): Amber D. Butler, Tannaz Sedghi, Joann R. Petrini, Ramin Ahmadi Lyme disease is the most commonly reported vector-borne illness in the United States. Since the institution of Nationally Notifiable surveillance efforts for Lyme disease in the United States in 1991, there has been a consistent increase in the number of reported cases. Thus, the need for targeted prevention strategies is underscored. The purpose of this study was to investigate knowledge about tick-borne diseases as well as beliefs and practices related to a variety of personal tick-borne disease prevention methods among individuals in southwestern Connecticut, a Lyme disease-endemic area. Between June and September 2014, a...

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Wednesday 2 December 2015

Laboratory diagnosis of Lyme borreliosis in Scottish patients: a novel approach.

Authors: Mavin S, Watson EJ, Evans R Abstract Traditional two-tier (enzyme immunoassay [EIA] screening and Western blot confirmation) testing for the laboratory diagnosis of Lyme borreliosis (LB) is expensive, lacks sensitivity in the diagnosis of early LB, cannot distinguish between current and past infection and cannot be used as a marker for treatment response. The aims of the present study is to investigate the role of the C6 EIA as a screening assay, as part of two-tier EIA test strategy, and its use as a marker of treatment response or resolving infection in a routine diagnostic laboratory. The C6 EIA was significantly less sensitive than the Enzygnost Lyme link VlsE/IgG EIA (169/249 vs. 190/249 reactive sera, respectively; P = 0.0455, Fishers exact two-tailed test). The two-...


Wednesday 2 December 2015

[Seropositivity of Borrelia burgdorferi in risky groups in Van region, Turkey].

Authors: Parlak M, Bayram Y, Çıkman A, Ceylan N, Berktaş M Abstract Lyme borreliosis, which is more prevalent in the northern hemisphere, is the most common tick-borne contagious disease among people living in the North America and Europe. The causative agent of Lyme borreliosis, Borrelia burgdorferi, is transmitted by the bites of ticks of the genus Ixodes. In Turkey, the seroprevalence of Lyme disease is increased in regions where ticks and tick-bite cases are prevalent. The present study aimed to determine the seroprevalence of Lyme borreliosis in people at risk, living in the rural areas of Van province, which is located in the eastern region of Turkey. No previous study on this topic has been performed in our province. The study included a total of 446 subjects (mean age: 3...


Wednesday 2 December 2015

This Scientist Says Your Fears About The Coming Genetic Engineering Revolution Are Overblown

This week, hundreds of scientists from around the world are descending on Washington D.C. for a three-day summit on a new technique that has spurred a major genetic revolution. Thanks to a gene-editing technique called CRISPR-Cas9, it is now not only possible, but easy, cheap and fast, to change, delete or replace genes in any plant or animal, including people. The range of hypothetical ways CRISPR could change our lives is staggering -- from creating wheat that is invulnerable to mildew to curing the world’s most intractable diseases. Anything that has DNA, which is to say, every living thing on earth, can now be more easily manipulated than ever before. When it comes to the human genome, especially, this raises fears as much as it raises hopes. You don’t have to dip that deep...


Wednesday 2 December 2015

The burden of Lyme borreliosis expressed in disability-adjusted life years

Conclusions: LB causes a substantial disease burden in the Netherlands. The vast majority of this burden is caused by patients with Lyme-related persisting symptoms. EM and disseminated Lyme have a more modest impact. Further research should focus on the mechanisms that trigger development of these persisting symptoms that patients and their physicians attribute to LB. (Source: The European Journal of Public Health)


Tuesday 1 December 2015

Lyme Neuroborreliosis

This article reviews clinical aspects of the diagnosis and treatment of Lyme neuroborreliosis, with focus on the United States. DISCLAIMER: The findings and conclusions in this article are those of the author and do not necessarily represent the official views of the National Institute of Allergy and Infectious Diseases. (Source: CONTINUUM)



Tuesday 1 December 2015

Appendix C: Practice Parameter: Diagnosis of Patients With Nervous System Lyme Borreliosis (Lyme Disease)

No abstract available (Source: CONTINUUM)

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Tuesday 1 December 2015

Lyme disease associated neuroretinitis - Case report.

We report a case of a 27-year-old woman with blurred vision on her right eye. Because of the suspicion of optic neuritis (multiplex sclerosis) neurological examination was ordered. Surprisingly, computer tomography of the brain revealed incomplete empty sella, which generally results not monocular, but bilateral optic nerve swelling. Opthalmological examination (ophthalmoscopy and optical coherence tomography) indicated not only monocular optic nerve, but retinal oedema next to the temporal part of the right optic disk. Visual evoked potentials (VEP) demonstrated no P100 latency delay and mild differences between the amplitudes of the responses of the left and right eye. Optical coherence tomography (OCT) demonstrated the swelling of the optic nerve head and oedematous retina at the tempor...


Tuesday 1 December 2015

Will Culling White‐Tailed Deer Prevent Lyme Disease?

Summary White‐tailed deer play an important role in the ecology of Lyme disease. In the United States, where the incidence and geographic range of Lyme disease continue to increase, reduction of white‐tailed deer populations has been proposed as a means of preventing human illness. The effectiveness of this politically sensitive prevention method is poorly understood. We summarize and evaluate available evidence regarding the effect of deer reduction on vector tick abundance and human disease incidence. Elimination of deer from islands and other isolated settings can have a substantial impact on the reproduction of blacklegged ticks, while reduction short of complete elimination has yielded mixed results. To date, most studies have been conducted in ecologic situations that are not rep...


Tuesday 1 December 2015

IJERPH, Vol. 12, Pages 15182-15203: GIS and Remote Sensing Use in the Exploration of Lyme Disease Epidemiology

Given the relatively recent recognition of Lyme disease (LD) by CDC in 1990 as a nationally notifiable infectious condition, the rise of reported human cases every year argues for a better understanding of its geographic scope. The aim of this inquiry was to explore research conducted on spatiotemporal patterns of Lyme disease in order to identify strategies for implementing vector and reservoir-targeted interventions. The focus of this review is on the use of GIS-based methods to study populations of the reservoir hosts, vectors and humans in addition to the spatiotemporal interactions between these populations. New GIS-based studies are monitoring occurrence at the macro-level, and helping pinpoint areas of occurrence at the micro-level, where spread within populations of reservoir hosts...


Monday 30 November 2015

Distribution and presentation of Lyme borreliosis in Scotland - analysis of data from a national testing laboratory.

Conclusion The incidence of Lyme borreliosis may be stabilising in Scotland but NHS Highland remains an area of high incidence. Lyme borreliosis should be considered in symptomatic patients that have had exposure to ticks and not just those with a definite tick bite. PMID: 26517097 [PubMed - in process] (Source: Journal of the Royal College of Physicians of Edinburgh)

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Monday 30 November 2015

What are the Most Common Arbovirus in Children in the US?

Discussion Arboviruses are viruses transmitted by arthropods (primarily mosquitos and ticks) to humans. Most infections are asymptomatic. Many others have mild symptoms such as an influenza-like illnesses. But for some patients they can cause neuroinvasive disease with meningitis, encephalitis and flaccid paralysis. Some patients also unfortunately die. Diagnosis is by serum or cerebrospinal fluid IgM antibody to the specific virus. Treatment is supportive only as there is no specific treatment and currently there are no vaccines for prevention. Mosquito bite and tick bite prevention are the best options for families and can be reviewed here. A systematic review of West Nile Virus (WNV) neuroinvasive disease in adults showed those infected can have a lengthy recovery with many sequelae, p...

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Monday 30 November 2015

What are the Most Common Arboviruses in Children in the US?

Discussion Arboviruses are viruses transmitted by arthropods (primarily mosquitos and ticks) to humans. Most infections are asymptomatic. Many others have mild symptoms such as an influenza-like illnesses. But for some patients they can cause neuroinvasive disease with meningitis, encephalitis and flaccid paralysis. Some patients also unfortunately die. Diagnosis is by serum or cerebrospinal fluid IgM antibody to the specific virus. Treatment is supportive only as there is no specific treatment and currently there are no vaccines for prevention. Mosquito bite and tick bite prevention are the best options for families and can be reviewed here. A systematic review of West Nile Virus (WNV) neuroinvasive disease in adults showed those infected can have a lengthy recovery with many sequelae, p...


Monday 30 November 2015

My Open Letter to Lyme Disease

Dear Lyme disease, I'm not angry. But I admit you made me miserable. You sneakily rushed through my veins. Anonymous, without a name, you tortured me for months. I didn't know who you were or where you came from. I would stare bleakly out my freshman dorm window, my eyes dull and my head throbbing. I blamed my school. During my first quarter at Northwestern University, my boyfriend and I broke up, my grandfather died, and I couldn't get out of bed for my morning classes. I reluctantly dropped a course after meeting with an adviser who thought I was struggling to acclimate to college. I was 850 miles from home and started to believe that I never should have left the East Coast. But Northwestern was the pennant on my corkboard at home; it was the sweatshirt my dad wore proudly to our local ...


Monday 30 November 2015

Diagnosing Septic Arthritis in the Synovial White Cell Count “Gray Zone”

Abstract Differentiating septic arthritis of the pediatric hip from other causes of hip pain and effusion continues to present a diagnostic challenge for the clinician. Although septic arthritis traditionally has been reported to have a synovial white blood cell count of 75,000 cells/mm3 or greater, lower counts can be seen in this condition. In cases where a synovial sample has been obtained and the cell count falls in the intermediate range between 25,000 and 75,000 cells/mm3, it is unclear what proportion of these cases may be truly septic hips. In this evidence-based review, we examine Heyworth et al’s study focusing on the predictive value of this intermediate white cell count range in a Lyme-endemic region. (Source: HSS Journal)


Sunday 29 November 2015

Repurposing Drugs in Oncology (ReDO)-clarithromycin as an anti-cancer agent.

Authors: Van Nuffel AM, Sukhatme V, Pantziarka P, Meheus L, Sukhatme VP, Bouche G Abstract Clarithromycin (CAM) is a well-known macrolide antibiotic available as a generic drug. CAM is traditionally used for many types of bacterial infections, treatment of Lyme disease and eradication of gastric infection with Helicobacter pylori. Extensive preclinical and clinical data demonstrate a potential role for CAM to treat various tumours in combination with conventional treatment. The mechanisms of action underlying the anti-tumour activity of CAM are multiple and include prolonged reduction of pro-inflammatory cytokines, autophagy inhibition, and anti-angiogenesis. Here, we present an overview of the current preclinical (in vitro and in vivo) and clinical evidence supporting the role of ...


Friday 27 November 2015

New, presumably tick-borne bacterium discovered in an Austrian fox

Ticks can transmit various diseases to people and animals. Some well-known diseases spread by ticks include tick-borne encephalitis (TBE) and Lyme disease. Researchers are hot on the trail of pathogens carried by ticks. The parasitologists recently discovered a new form of the bacterium Candidatus Neoehrlichia in a red fox from the Austrian state of Vorarlberg. The pathogen might also be transmittable to humans, they warn. (Source: ScienceDaily Headlines)


Friday 27 November 2015

New and presumably tick-borne bacterium discovered in an Austrian fox

(University of Veterinary Medicine -- Vienna) Ticks can transmit various diseases to people and animals. Some well-known diseases spread by ticks include tick-borne encephalitis (TBE) and Lyme disease. Researchers at the Vetmeduni Vienna are hot on the trail of pathogens carried by ticks. The parasitologists recently discovered a new form of the bacterium Candidatus Neoehrlichia in a red fox from Austrian. The pathogen might also be transmittable to humans. The results were published in the journal Parasites & Vectors. (Source: EurekAlert! - Infectious and Emerging Diseases)


Wednesday 25 November 2015

Methodological quality of guidelines for management of Lyme neuroborreliosis

Background: Many aspects of clinical management of Lyme neuroborreliosis are subject to intense debates. Guidelines show considerable variability in their recommendations, leading to divergent treatment regimes. The most pronounced differences in recommendations exist between guidelines from scientific societies and from patient advocacy groups. Assessment of the methodological quality of these contradictory guideline recommendations can be helpful for healthcare professionals. Methods: Systematic searches were conducted in MEDLINE and databases of four international and national guideline organizations for guidelines on Lyme neuroborreliosis published from 1999–2014. Characteristics (e.g., year of publication, sponsoring organization) and key recommendations were extracted from each gui...


Tuesday 24 November 2015

Long-term Assessment of Post-Treatment Symptoms in Patients With Culture-Confirmed Early Lyme Disease

Conclusions. PTLDS may persist for >10 years in some patients with culture-confirmed early Lyme disease. Such long-standing symptoms were not associated with functional impairment or a particular strain of B. burgdorferi. (Source: Clinical Infectious Diseases)


Monday 23 November 2015

A tick that feeds on birds may increase the range of Lyme disease

(Entomological Society of America) A tick that is not known to bite people may play a role in the transmission of Lyme disease, according to an article in the Journal of Medical Entomology. (Source: EurekAlert! - Medicine and Health)

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Monday 23 November 2015

Ixodes scapularis dystroglycan-like protein promotes Borrelia burgdorferi migration from the gut

In conclusion, we have identified a dystroglycan-like protein in I. scapularis gut that can bind to B. burgdorferi and promotes B. burgdorferi migration from the tick gut. Key messages B. burgdorferi exploits tick proteins to orchestrate its transmission to the host. B. burgdorferi is able bind to an I. scapularis dystroglycan-like protein (ISDLP). Inhibition of ISDLP in ticks results in lower B. burgdorferi transmission to mice. ISDLP is a potential target to prevent Lyme borreliosis. (Source: Journal of Molecular Medicine)

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Monday 23 November 2015

Cross-reactivity between Lyme and syphilis screening assays: Lyme disease does not cause false-positive syphilis screens

This study supports the previously described cross-reactivity of Lyme screening among syphilis-positive sera and reports evidence against the possibility of false-positive syphilis screening tests resulting from previous Borrelia burgdorferi infection. (Source: Diagnostic Microbiology and Infectious Disease)


Monday 23 November 2015

Monoclonal Antibodies for the Diagnosis of Borrelia crocidurae.

Authors: Aurélien FF, Mediannikov O, Nappez C, Azza S, Raoult D, Drancourt M Abstract Relapsing fever borreliae, produced by ectoparasite-borne Borrelia species, cause mild to deadly bacteremia and miscarriage. In the perspective of developing inexpensive assays for the rapid detection of relapsing fever borreliae, we produced 12 monoclonal antibodies (MAbs) against Borrelia crocidurae and characterized the two exhibiting the highest titers. P3A10 MAb reacts with the 35.6-kDa flagellin B (flaB) of B. crocidurae while P6D9 MAb recognizes a 35.1-kDa variable-like protein (Vlp) in B. crocidurae and a 35.2-kDa Vlp in Borrelia duttonii. Indirect immunofluorescence assay incorporating relapsing fever and Lyme group borreliae and 11 blood-borne organisms responsible for fever in West Afr...


Monday 23 November 2015

Cross reactivity between Lyme and syphilis screening assays: Lyme disease does not cause false positive syphilis screens

This study supports the previously-described cross-reactivity of Lyme screening among syphilis-positive sera, and reports evidence against the possibility of false-positive syphilis screening tests resulting from previous Borrelia burgdorferi infection. (Source: Diagnostic Microbiology and Infectious Disease)


Saturday 21 November 2015

Coinfection by Ixodes Tick-Borne Pathogens: Ecological, Epidemiological, and Clinical Consequences.

Authors: Diuk-Wasser MA, Vannier E, Krause PJ Abstract Ixodes ticks maintain a large and diverse array of human pathogens in the enzootic cycle, including Borrelia burgdorferi and Babesia microti. Despite the poor ecological fitness of B. microti, babesiosis has recently emerged in areas endemic for Lyme disease. Studies in ticks, reservoir hosts, and humans indicate that coinfection with B. burgdorferi and B. microti is common, promotes transmission and emergence of B. microti in the enzootic cycle, and causes greater disease severity and duration in humans. These interdisciplinary studies may serve as a paradigm for the study of other vector-borne coinfections. Identifying ecological drivers of pathogen emergence and host factors that fuel disease severity in coinfected individua...


Friday 20 November 2015

Lyme Disease Diagnosis

Serology is the mainstay of confirmation of Lyme borreliosis; direct detection has limited application. Because standardized 2-tier testing (STTT) has been commonly used since the mid 1990s, standardization and performance have improved. STTT detection of early, localized infection is poor; that of late disease is good. The best indicator of stage 1 infection, erythema migrans, is presented in the majority of US cases and should prompt treatment without testing. Clinical and epidemiologic correlates should be carefully assessed before ordering STTT. STTT has great value in confirming extracutaneous infection. Recent developments promise to improve performance, particularly in early disease detection. (Source: Clinics in Laboratory Medicine)

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Friday 20 November 2015

Friends from New York to Mexico make video for friend with Lyme disease

Chantelle Lewis, 31, from Falmouth, Cornwall, caught Lyme disease while working on a superyacht in the Caribbean. She cried 'the happiest tears' after receiving the supportive video. (Source: the Mail online | Health)


Friday 20 November 2015

Gender Differences in Childhood Lyme Neuroborreliosis.

Conclusion. Girls and boys have different clinical presentations of LNB, and boys have a higher level of inflammation than girls independent of the clinical presentation. PMID: 26576072 [PubMed - as supplied by publisher] (Source: Behavioural Neurology)


Friday 20 November 2015

Intermediate uveitis and multiple sclerosis: to scan or not to scan

The investigation and management of inflammatory eye disease is complex and relies on detailed history taking and examination. It is not therefore unexpected that many patients are over-investigated. A question that has caused much debate in the past is whether patients with intermediate uveitis (IU), particularly young Caucasian women with no neurological symptoms, should have routine neuroimaging to ‘screen’ for multiple sclerosis (MS). In this editorial, we discuss the key issues related to the clinical presentation of IU, its association with MS and the rationale for investigation; in particular, we put forward our view that neuroimaging should not be carried out as a screening tool for patients with IU. IU is the term given to inflammation, which has the vitreous as its fo...


Thursday 19 November 2015

Assessing the abundance, seasonal questing activity, and Borrelia and tick-borne encephalitis virus (TBEV) prevalence of Ixodes ricinus ticks in a Lyme borreliosis endemic area in Southwest Finland

Publication date: Available online 24 October 2015 Source:Ticks and Tick-borne Diseases Author(s): Jani J. Sormunen, Tero Klemola, Eero J. Vesterinen, Ilppo Vuorinen, Jukka Hytönen, Jari Hänninen, Kai Ruohomäki, Ilari E. Sääksjärvi, Elina Tonteri, Ritva Penttinen Studies have revealed that Ixodes ricinus (Acari: Ixodidae) have become more abundant and their geographical distribution extended northwards in some Nordic countries during the past few decades. However, ecological data of tick populations in Finland are sparse. In the current study, I. ricinus abundance, seasonal questing activity, and their Borrelia spp. and tick-borne encephalitis virus (TBEV) prevalence were evaluated in a Lyme borreliosis endemic area in Southwest Finland, Seili Island, where a previous stu...


Thursday 19 November 2015

Fine-scale genetic structure of woodrat populations (Genus: Neotoma) and the spatial distribution of their tick-borne pathogens

Publication date: Available online 25 October 2015 Source:Ticks and Tick-borne Diseases Author(s): Janet Foley, Daniel Rejmanek, Colin Foley, Marjorie Matocq Dusky-footed woodrats are territorial cricetid rodents that individually occupy large stick houses from which they foray to gather food, find mates, and engage in other activities. These rodents are often bitten by Ixodes spp. ticks and are reservoirs of some strains of tick-borne bacterial pathogens such as Anaplasma phagocytophilum and Borrelia burgdorferi. Limited dispersal by hosts and vectors could create fine-scale population structure where related hosts and pathogen exposure are co-distributed in space. To quantify population genetic structure and infection status, we genotyped 167 woodrats using a panel of 15 microsatel...


Thursday 19 November 2015

Occurrence of Borrelia burgdorferi s.l. in different genera of mosquitoes (Culicidae) in Central Europe

Publication date: Available online 12 November 2015 Source:Ticks and Tick-borne Diseases Author(s): Christian Melaun, Sina Zotzmann, Vanesa Garcia Santaella, Antje Werblow, Helga Zumkowski-Xylander, Peter Kraiczy, Sven Klimpel Lyme disease or Lyme borreliosis is a vector-borne infectious disease caused by spirochetes of the Borrelia burgdorferi sensu lato complex. Some stages of the borrelial transmission cycle in ticks (transstadial, feeding and co-feeding) can potentially occur also in insects, particularly in mosquitoes. In the present study, adult as well as larvae mosquitoes were collected at 42 different geographical locations throughout Germany. This is the first study, in which German mosquitoes were analysed for the presence of Borrelia spp. Targeting two specific borreli...


Thursday 19 November 2015

Testing practices and volume of non-Lyme tickborne diseases in the United States

Publication date: Available online 30 October 2015 Source:Ticks and Tick-borne Diseases Author(s): Neeta P. Connally, Alison F. Hinckley, Katherine A. Feldman, Melissa Kemperman, David Neitzel, Siok-Bi Wee, Jennifer L. White, Paul S. Mead, James I. Meek Large commercial laboratories in the United States were surveyed regarding the number of specimens tested for eight tickborne diseases in 2008. Seven large commercial laboratories reported testing a total of 2,927,881 specimens nationally (including Lyme disease). Of these, 495,585 specimens (17%) were tested for tickborne diseases other than Lyme disease. In addition to large commercial laboratories, another 1051 smaller commercial, hospital, and government laboratories in four states (CT, MD, MN, and NY) were surveyed regarding...


Thursday 19 November 2015

Truncated seasonal activity patterns of the western blacklegged tick (Ixodes pacificus) in central and southern California

Publication date: Available online 25 October 2015 Source:Ticks and Tick-borne Diseases Author(s): Andrew J. MacDonald, Cheryl J. Briggs Patterns of seasonal activity and density of host-seeking western blacklegged ticks, Ixodes pacificus, were investigated in central and southern California. Weekly to monthly drag sampling was undertaken at two sites in Santa Barbara County and one site in Los Angeles County over multiple years. Adult I. pacificus became active in the winter (late November) and were rare or absent by late April to early May. Nymphal ticks became active in early to late February, were absent by early May to early June, and were rarely encountered using the drag method throughout their period of peak seasonal activity. Larval ticks became active earlier in the season, o...

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Wednesday 18 November 2015

Babesiosis and Lyme disease co-infection in a female patient returning from the United States.

Authors: Surgers L, Belkadi G, Foucard A, Lalande V, Girard PM, Hennequin C PMID: 26525187 [PubMed - as supplied by publisher] (Source: Medecine et Maladies Infectieuses)


Wednesday 18 November 2015

Development of a Multiantigen Panel for Improved Detection of Borrelia burgdorferi Infection in Early Lyme Disease [Immunoassays]

We examined novel and established antigen markers to develop a multiplex panel that identifies early infection using the combined sensitivity of multiple markers while simultaneously maintaining high specificity by requiring positive results for two markers to designate a positive test. Ten markers were selected from our initial analysis of 62 B. burgdorferi surface proteins and synthetic peptides by assessing binding of IgG and IgM to each in a training set of Lyme disease patient samples and controls. In a validation set, this 10-antigen panel identified a higher proportion of early-Lyme-disease patients as positive at the baseline or posttreatment visit than two-tiered testing (87.5% and 67.5%, respectively; P < 0.05). Equivalent specificities of 100% were observed in 26 healthy cont...


Tuesday 17 November 2015

Why FDA should oversee laboratory developed tests

By: Peter Lurie, M.D., M.P.H. Today FDA is issuing a report that illustrates the real and potential harms to patients and to public health from certain laboratory developed tests (LDTs) – tests that are designed, manufactured and used in a single laboratory. When FDA first began regulating medical devices under the Medical Device Amendments in the 1970s, we chose not to enforce applicable regulatory requirements for LDTs because they were relatively simple tests generally confined to local labs, and often used for rare conditions. But times have changed. LDTs have increased in complexity and availability and are now frequently used to diagnose common, serious medical conditions, including cancer and heart disease, with potentially greater impact on patients. And yet, LDTs are still under...


Sunday 15 November 2015

A Systematic Approach to the Evaluation of a Limping Child.

Authors: Naranje S, Kelly DM, Sawyer JR Abstract A limp is defined as a deviation from a normal age-appropriate gait pattern resulting in an uneven, jerky, or laborious gait. It can be caused by pain, weakness, or deformity as a result of a variety of conditions. Transient synovitis is the most common diagnosis. Other causes of acute limp include contusion, foreign body in the foot, fracture, osteomyelitis, septic arthritis, reactive arthritis, and Lyme arthritis. Causes of chronic limp include rheumatic disease, dermatomyositis, acute rheumatic fever, inflammatory bowel disease, and systemic lupus erythematosus. Evaluation of a limping child should begin with a history focused on identifying pain, trauma, and associated systemic symptoms. For a limping child with focal findings on...

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Friday 13 November 2015

Borrelial Lymphocytoma in Children

Conclusions: BL in children, treated with recommended antibiotics, is a mild disease with a good prognosis. (Source: The Pediatric Infectious Disease Journal)


Friday 13 November 2015

Lyme disease sufferer Tahlia Smith had live parasites in her blood

Lyme disease sufferer Tahlia Smith, 21, from the New South Wales Hunter Region has flown to Germany to undergo controversial treatment where doctors found live parasites in her blood (Source: the Mail online | Health)


Friday 13 November 2015

Association of Immune Response to Endothelial Cell Growth Factor With Early Disseminated and Late Manifestations of Lyme Disease but Not Posttreatment Lyme Disease Syndrome

Endothelial cell growth factor has been recently proposed as a potential autoantigen in manifestations of Lyme disease that are thought to involve immune-mediated mechanisms. Our findings indicate that a humoral immune response to this protein is not associated with posttreatment Lyme disease syndrome. (Source: Clinical Infectious Diseases)



Thursday 12 November 2015

BORRELIA BABESIA REMEDY (Babesia Microti, Borrelia Burgdorferi Nosode) Liquid [Deseret Biologicals, Inc.]

Updated Date: Nov 12, 2015 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))


Thursday 12 November 2015

Causes of neuropathy in patients referred as “idiopathic neuropathy”

This article is protected by copyright. All rights reserved. (Source: Muscle and Nerve)


Tuesday 10 November 2015

Is Lyme the New AIDS? Part Three: A Caution to Gay Men

Note: This is the third and final entry in a series about how my life has been devastated by Lyme disease. With the advent of PrEP and effective medical interventions for HIV, I am truly disturbed that gay men -- first, younger generations, but increasingly people my age who lived through the plague of AIDS -- increasingly are rejecting the use of condoms and feeling invulnerable to potential sexually transmitted infections. Although the CDC claims absolutely that Lyme disease cannot be transmitted sexually, objective scientific research and anecdotes of those whose partners have Lyme argue otherwise. You do not want Lyme disease. It will change your life for the worse, not only by potentially disabling you at too young an age, but by rendering you an untouchable to many primary care phys...

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Tuesday 10 November 2015

Long-Term Survival of Borrelia burgdorferi Lacking the Hibernation Promotion Factor Homolog in the Unfed Tick Vector [Molecular Pathogenesis]

Borrelia burgdorferi, a causative agent of Lyme borreliosis, is a zoonotic pathogen that survives in nutrient-limited environments within a tick, prior to transmission to its mammalian host. Survival under these prolonged nutrient-limited conditions is thought to be similar to survival during stationary phase, which is characterized by growth cessation and decreased protein production. Multiple ribosome-associated proteins are implicated in stationary-phase survival of Escherichia coli. These proteins include hibernation-promoting factor (HPF), which dimerizes ribosomes and prevents translation of mRNA. Bioinformatic analyses indicate that B. burgdorferi harbors an hpf homolog, the bb0449 gene. BB0449 protein secondary structure modeling also predicted HPF-like structure and function. Howe...


Tuesday 10 November 2015

Lyme disease in Poland - A serious problem?

CONCLUSIONS: The reported incidence of LD in Poland, in our opinion, may be biased by overreporting and overdiagnosis. Nonspecific musculoskeletal and joint pain are the most frequent cause of LD suspicion and hospitalization. There is a necessity of better tests for active LD confirmation (especially in patients with musculoskeletal pain) as seroprevalence of anti Borrelia burgdorferi antibodies is high in endemic regions. PMID: 26641887 [PubMed - as supplied by publisher] (Source: Advances in Medical Sciences)


Tuesday 10 November 2015

Outer Surface Protein OspC Is an Antiphagocytic Factor That Protects Borrelia burgdorferi from Phagocytosis by Macrophages [Molecular Pathogenesis]

In this study, we showed that the ospC-deficient spirochete could not establish infection in NOD-scid IL2rnull mice that lack B cells, T cells, NK cells, and lytic complement. The ospC mutant also could not establish infection in anti-Ly6G-treated SCID and C3H/HeN mice (depletion of neutrophils). However, depletion of mononuclear phagocytes at the skin site of inoculation in SCID and C3H/HeN mice allowed the ospC mutant to establish infection in vivo. In phagocyte-depleted mice, the ospC mutant was able to colonize the joints and triggered neutrophilia during dissemination. Furthermore, we found that phagocytosis of green fluorescent protein (GFP)-expressing ospC mutant spirochetes by murine peritoneal macrophages and human THP-1 macrophage-like cells, but not in PMN-HL60, was significantl...


Tuesday 10 November 2015

Lyme disease in Poland – A serious problem?

Conclusions The reported incidence of LD in Poland, in our opinion, may be biased by overreporting and overdiagnosis. Nonspecific musculoskeletal and joint pain are the most frequent cause of LD suspicion and hospitalization. There is a necessity of better tests for active LD confirmation (especially in patients with musculoskeletal pain) as seroprevalence of anti Borrelia burgdorferi antibodies is high in endemic regions. (Source: Advances in Medical Sciences)

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Tuesday 10 November 2015

Lyme disease and juvenile idiopathic arthritis – a pediatric case report

Discussion In this case, the resolution of cutaneous symptoms and the persistence of chronic arthritis suggest that the strong likelihood of infection by Borrelia has triggered Juvenile Idiopathic Arthritis. (Source: Revista Brasileira de Reumatologia)


Monday 9 November 2015

Model Jessica Bennett left bed bound after medics failed to diagnose Lyme disease

Jessica Bennett, 31, of Welwyn Garden City, Hertfordshire, suffered seizures, speech problems, hair loss, chronic insomnia and severe bloating due to Lyme disease she caught from a tick. (Source: the Mail online | Health)


Thursday 5 November 2015

Distribution and Habitat of Ixodes pacificus (Acari: Ixodidae) and Prevalence of Borrelia burgdorferi in Utah

Knowledge about the distribution and abundance of the western black-legged tick, Ixodes pacificus Cooley and Kohls, in Utah is limited. Recent concerns over tick-borne diseases in Utah, primarily Lyme disease, have reinvigorated the need to understand the distribution and habitats favored by this tick species. We surveyed 157 sites throughout Utah to examine the distribution, abundance, and habitat of I. pacificus. In total, 343 adult ticks were collected from 2011 to 2013. Specifically, 119 I. pacificus, 217 Dermacentor andersoni Stiles, six D. albipictus Packard, and one D. hunteri Bishopp were collected. Overall, tick abundance was relatively low in the areas evaluated in Utah. I. pacificus collections were limited to sites above 1700 m. Ninety-two percent of I. pacificus were captured ...


Thursday 5 November 2015

Seasonal Activity, Density, and Collection Efficiency of the Blacklegged Tick (Ixodes scapularis) (Acari: Ixodidae) in Mid-Western Pennsylvania

Although Pennsylvania has recently reported the greatest number of Lyme disease cases in the United States, with the largest increase for PA occurring in its western region, the population biology of the blacklegged tick (Ixodes scapularis Say) has not been adequately characterized in western PA. We studied the seasonal activity of host-seeking I. scapularis larvae, nymphs, and adults in mid-western PA over the course of a year, including a severe winter, and determined their absolute densities and collection efficiencies using replicated mark-release-recapture or removal methods. Our results are compared to those from similar studies conducted in the highly Lyme disease endemic Hudson Valley region of southeastern New York State. The seasonal activity of I. scapularis was intermediate bet...

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Wednesday 4 November 2015

Quantification of Borrelia burgdorferi Membrane Proteins in Human Serum: A New Concept for Detection of Bacterial Infection

Analytical ChemistryDOI: 10.1021/acs.analchem.5b02803 (Source: Analytical Chemistry)


Wednesday 4 November 2015

Application of Nanotrap technology for high sensitivity measurement of urinary outer surface protein A carboxyl-terminus domain in early stage Lyme borreliosis

ObjectivesPrompt antibiotic treatment of early stage Lyme borreliosis (LB) prevents progression to severe multisystem disease. There is a clinical need to improve the diagnostic specificity of early stage Lyme assays in the period prior to the mounting of a robust serology response. Using a novel analyte harvesting nanotechnology, Nanotrap particles, we evaluated urinary Borrelia Outer surface protein A (OspA) C-terminus peptide in early stage LB before and after treatment, and in patients suspected of late stage disseminated LB.MethodWe employed Nanotrap particles to concentrate urinary OspA and used a highly specific anti-OspA monoclonal antibody (mAb) as a detector of the C-terminus peptides. We mapped the mAb epitope to a narrow specific OspA C-terminal domain OspA236-239 conserved acr...


Wednesday 4 November 2015

A Highly Expressed Human Protein, Apolipoprotein B-100, Serves as an Autoantigen in a Subgroup of Patients With Lyme Disease

To discover novel autoantigens associated with Lyme arthritis (LA), we identified T-cell epitopes presented in vivo by human leukocyte antigen (HLA)–DR molecules in patients' inflamed synovial tissue or joint fluid and tested each epitope for autoreactivity. Using this approach, we identified the highly expressed human protein, apolipoprotein B-100 (apoB-100), as a target of T- and B-cell responses in a subgroup of LA patients. Additionally, the joint fluid of these patients had markedly elevated levels of apoB-100 protein, which may contribute to its autoantigenicity. In patients with antibiotic-refractory LA, the magnitude of apoB-100 antibody responses correlated with increased numbers of plasma cells in synovial tissue, greater numbers and activation of endothelial cells, and mor...


Monday 2 November 2015

Medical News Today: How to remove a tick

Around 30,000 new cases of Lyme disease are reported each year. Avoiding ticks and removing them when necessary are essential skills for anyone who likes to venture into nature. (Source: Health News from Medical News Today)


Sunday 1 November 2015

'Water on the knee' could be early sign of Lyme disease

Spontaneous knee effusion, also known as 'water on the knee,' can be a primary symptom of Lyme disease, even when patients do not exhibit a 'bull's eye' rash, another common Lyme disease symptom. According to a literature review, early diagnosis and antibiotic treatment can prevent the development of Lyme disease's more severe symptoms. (Source: ScienceDaily Headlines)


Sunday 1 November 2015

Water on the Knee Can Be Sign of Lyme Disease

Spontaneous knee effusion, also known as "water on the knee," can be a primary symptom of Lyme disease, even when patients do not exhibit a "bull's eye" rash, another common Lyme disease symptom. According to a literature review appearing in the November issue of The Journal of the American Academy of Orthopaedic Surgeons (JAAOS), early diagnosis and antibiotic treatment can prevent the development of Lyme disease's more severe symptoms. (Source: Disabled World)


Sunday 1 November 2015

'Water on the knee' could be early sign of Lyme disease

(American Academy of Orthopaedic Surgeons) Spontaneous knee effusion, also known as 'water on the knee,' can be a primary symptom of Lyme disease, even when patients do not exhibit a 'bull's eye' rash, another common Lyme disease symptom. According to a literature review appearing in the November issue of The Journal of the American Academy of Orthopaedic Surgeons (JAAOS), early diagnosis and antibiotic treatment can prevent the development of Lyme disease's more severe symptoms. (Source: EurekAlert! - Medicine and Health)

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Wednesday 28 October 2015

Absence of Borrelia burgdorferi in the myocardium of subjects with normal left ventricular systolic function: a study using PCR and electron microscopy.

CONCLUSIONS: The absence of Bb in the myocardium of individuals who undergo cardiac surgery and have normal LV systolic function supports the idea of Bb pathogenicity in the development of DCM. PMID: 26498214 [PubMed - as supplied by publisher] (Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub)

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Tuesday 27 October 2015

Spirochetal motility and chemotaxis in the natural enzootic cycle and development of Lyme disease.

Authors: Motaleb MA, Liu J, Mark Wooten R Abstract Two-thirds of all bacterial genomes sequenced to-date possess an organelle for locomotion, referred to as flagella, periplasmic flagella or type IV pili. These genomes may also contain a chemotaxis-signaling system which governs flagellar rotation, thus leading a coordinated function for motility. Motility and chemotaxis are often crucial for infection or disease process caused by pathogenic bacteria. Although motility-associated genes are well-characterized in some organisms, the highly orchestrated synthesis, regulation, and assembly of periplasmic flagella in spirochetes are just being delineated. Recent advances were fostered by development of unique genetic manipulations in spirochetes coupled with cutting-edge imaging techniq...


Monday 26 October 2015

Do citation trends reflect epidemiologic patterns? Assessing MRSA, emerging and re-emerging pathogens, 1963–2014

Conclusions: The Type I pattern pathogens had varied trends in disease incidence in the years following the exponential growth and subsequent decline in the number of citations. Their differing epidemiologic patterns did not correlate with their pattern of citations. We conclude that citation trends on MRSA cannot be used to determine past epidemiologic trends and also that the citation trend for MRSA in 1995–2011 most closely resembled that for HIV in 1981–1998. (Source: BMC Infectious Diseases)


Saturday 24 October 2015

Use of in vivo Expression Technology for the Identification of Putative Host Adaptation Factors of the Lyme Disease Spirochete

The causative agent of Lyme disease, Borrelia burgdorferi, is an obligate parasite that requires either a tick vector or a mammalian host for survival. Identification of the bacterial genes that are specifically expressed during infection of the mammalian host could provide targets for novel therapeutics and vaccines. In vivo expression technology (IVET) is a reporter-based promoter trap system that utilizes selectable markers to identify promoters of bacterial host-specific genes. Using previously characterized genes for in vivo and in vitro selection, this study utilized an IVET system that allows for selection of B. burgdorferi sequences that act as active promoters only during murine infection. This promoter trap system was able to successfully distinguish active promoter sequences bot...


Saturday 24 October 2015

No Geographic Correlation between Lyme Disease and Death Due to 4 Neurodegenerative Disorders, United States, 2001-2010.

Authors: Forrester JD, Kugeler KJ, Perea AE, Pastula DM, Mead PS Abstract Associations between Lyme disease and certain neurodegenerative diseases have been proposed, but supportive evidence for an association is lacking. Similar geographic distributions would be expected if 2 conditions were etiologically linked. Thus, we compared the distribution of Lyme disease cases in the United States with the distributions of deaths due to Alzheimer disease, amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), and Parkinson disease; no geographic correlations were identified. Lyme disease incidence per US state was not correlated with rates of death due to ALS, MS, or Parkinson disease; however, an inverse correlation was detected between Lyme disease and Alzheimer disease. The abse...


Saturday 24 October 2015

Structure of decorin binding protein B from Borrelia burgdorferi and its interactions with glycosaminoglycans

Publication date: December 2015 Source:Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, Volume 1854, Issue 12 Author(s): Wei Feng, Xu Wang Decorin-binding proteins (DBPs), DBPA and DBPB, are surface lipoproteins on Borrelia burgdorferi, the causative agent of Lyme disease. DBPs bind to the connective tissue proteoglycan decorin and facilitate tissue colonization by the bacterium. Although structural and biochemical properties of DBPA are well understood, little is known about DBPB. In current work, we determined the solution structure of DBPB from strain B31 of B. burgdorferi and characterized its interactions with glycosaminoglycans (GAGs). Our structure shows that DBPB adopts the same topology as DBPA, but possesses a much shorter terminal helix, resulting in a longer u...

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Friday 23 October 2015

Lyme Disease Presenting As Multiple Ischaemic StrokesLyme Disease Presenting As Multiple Ischaemic Strokes

This unusual case highlights the need to consider CNS Lyme vasculitis in patients with cryptogenic strokes, particularly those who are younger and who come from areas where Lyme disease is endemic. Practical Neurology (Source: Medscape Today Headlines)


Friday 23 October 2015

Vesiculobullous and hemorrhagic erythema migrans: uncommon variants of a common disease

ConclusionsIt is important to recognize the vesiculobullous and hemorrhagic variants of ECM in order to minimize the provision of inappropriate antibiotic treatment for other diagnoses. Early diagnosis of ECM and the initiation of appropriate antibiotics may prevent late complications of Lyme disease. (Source: International Journal of Dermatology)


Thursday 22 October 2015

Lyme Disease Is on the Rise

Title: Lyme Disease Is on the RiseCategory: Doctor's & Expert's views on SymptomsCreated: 4/29/2000 12:00:00 AMLast Editorial Review: 10/22/2015 12:00:00 AM (Source: MedicineNet Arthritis General)


Thursday 22 October 2015

Flagellar motility of the pathogenic spirochetes

Publication date: Available online 17 October 2015 Source:Seminars in Cell & Developmental Biology Author(s): Charles W. Wolgemuth Bacterial pathogens are often classified by their toxicity and invasiveness. The invasiveness of a given bacterium is determined by how capable the bacterium is at invading a broad range of tissues in its host. Of mammalian pathogens, some of the most invasive come from a group of bacteria known as the spirochetes, which cause diseases such as syphilis, Lyme disease, relapsing fever and leptospirosis. Most of the spirochetes are characterized by their distinct shapes and unique motility. They are long, thin bacteria that can be shaped like flat-waves, helices, or have more irregular morphologies. Like many other bacteria, the spirochetes use long, he...


Thursday 22 October 2015

Incidence and Patterns of Extended-Course Antibiotic Therapy in Patients Evaluated for Lyme Disease

Conclusions. Insurance claims data suggest that the use of extended courses of antibiotics and multiple antibiotics in the treatment of LD has increased in recent years. (Source: Clinical Infectious Diseases)


Wednesday 21 October 2015

So what IS the truth about the Lyme disease 'epidemic'?

Phones 4u's John Caudwell, (pictured with daughters Rebekah and Rhiannon) believes Lyme disease is behind a host of health problems that his family suffers from. (Source: the Mail online | Health)


Wednesday 21 October 2015

The controversy over the chronic form of Lyme disease

(Source: BBC News | Health | UK Edition)


Tuesday 20 October 2015

Borrelia burgdorferi HtrA: evidence for twofold proteolysis of outer membrane protein p66

In this study, HtrA was found to degrade B. burgdorferi outer membrane protein p66 protein, as well as inhibit its transcription. In intact spirochetes, evidence is given for co‐localization of HtrA and p66 in membrane lipid rafts. Taken together, the data support a role for HtrA in the regulation of p66 expression. (Source: Molecular Microbiology)


Monday 19 October 2015

The Salt‐Sensitive Structure and Zinc Inhibition of Borrelia burgdorferi Protease BbHtrA

In this study, we utilized size exclusion chromatography and blue native polyacrylamide gel electrophoresis (BN‐PAGE) to demonstrate BbHtrA oligomeric structures which were substrate‐independent and salt sensitive. Examination of the influence of transition metals on the activity of BbHtrA revealed that this protease is inhibited by Zn2+>Cu2+>Mn2+. Extending this analysis to two other HtrA proteases, E. coli DegP and HtrA1, revealed that all three HtrA proteases were reversibly inhibited by ZnCl2 at all micro molar concentrations examined. Commercial inhibitors for HtrA proteases are not available and physiologic HtrA inhibitors are unknown. Our observation of conserved zinc inhibition of HtrA proteases will facilitate structural and functional studies of additional members of th...

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Saturday 17 October 2015

Supervised Resistance Exercise for Patients with Persistent Symptoms of Lyme Disease

Conclusions: Although larger and controlled studies are necessary, supervised resistance exercise was feasible and may benefit patients with persistent symptoms of Lyme disease. (Source: Medicine and Science in Sports and Exercise)


Saturday 17 October 2015

Tick saliva: Paving the way for the stowaway Borrelia

This article is protected by copyright. All rights reserved. (Source: Experimental Dermatology)


Wednesday 14 October 2015

The Positive Predictive Value of Lyme Elisa for the Diagnosis of Lyme Disease in Children

By using a Lyme enzyme-linked immunosorbent assay (ELISA), we demonstrated that high ELISA index values are strongly predictive of Lyme disease. In children with clinical presentations consistent with Lyme disease, ELISA index values ≥3.0 had a positive predictive value of 99.4% (95% confidence interval: 98.1–99.8%) for Lyme disease, making a supplemental Western immunoblot potentially unnecessary. (Source: The Pediatric Infectious Disease Journal)


Tuesday 13 October 2015

Lyme disease jab is 'in sight' as MassBiologics scientists reveal breakthrough

Scientists at UMass Medical School MassBiologics have identified an antibody that could protect against the tick-borne disease afflicting Yolana Foster and her daughter Bella Hadid, 18. (Source: the Mail online | Health)

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Tuesday 13 October 2015

Medical News Today: Ticks and Lyme disease: how worried should we be?

With recent reports of a rise in Lyme disease cases, we try to find out just how worried should we be about the pesky bugs closely associated with the condition: ticks. (Source: Health News from Medical News Today)


Monday 12 October 2015

Concern about rise in UK Lyme disease cases

"Surging numbers of people are being diagnosed with Lyme disease as cases spread from rural areas to the suburbs," the Daily Mail reports. The ongoing rise in Lyme disease cases in the UK – thought to be driven by climate change, leading to warmer winters – has been known by public health officials for some time. Reported cases in England and Wales rose from 268 in 2001 to 959 in 2011, but the true figure is thought be much higher. Current estimates put the actual figure at around 3,000 cases a year in England and Wales.It may also be the case that the disease is, as the Mail puts it, "moving into the suburbs," or least into the parks. A recent study from September 2015 found ticks that could potentially carry infection in two South London parks: Richmond Par...


Monday 12 October 2015

The symptoms of Lyme disease are a lot like flu - which is perhaps why NHS treatment is so inadequate

It took four years for me to be diagnosed - doctors and patients alike need to know much more about this illness to prevent more lives being ruined (Source: Telegraph Health)


Monday 12 October 2015

Lyme disease cases quadruples in 12 years with over 1,000 diagnosed in 2013 

Surging numbers of people are being diagnosed with Lyme disease, experts warn, as cases are spreading from rural areas to the suburbs. The debilitating disease is spread by tick bites. (Source: the Mail online | Health)


Monday 12 October 2015

Prevalence and spectrum of residual symptoms in Lyme neuroborreliosis after pharmacological treatment: a systematic review

Abstract Controversy exists about residual symptoms after pharmacological treatment of Lyme neuroborreliosis. Reports of disabling long-term sequels lead to concerns in patients and health care providers. We systematically reviewed the available evidence from studies reporting treatment of Lyme neuroborreliosis to assess the prevalence and spectrum of residual symptoms after treatment. A literature search was performed in three databases and three clinical trial registers to find eligible studies reporting on residual symptoms in patients after pharmacological treatment of LNB. Diagnosis must have been performed according to consensus-derived case definitions. No restrictions regarding study design or language were set. Symptom prevalence was pooled using a random-effects model. F...


Saturday 10 October 2015

Ticks Carrying Lyme Disease Found in London

Visitors to two popular parks in South London are at risk of coming into contact with ticks that can transmit Lyme disease to humans, according to new research published in Medical and Veterinary Entomology. (Source: Disabled World)

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Friday 9 October 2015

Bella and Anwar Hadid both have Lyme disease, Yolanda Foster reveals

The 51-year-old reality star was honoured at the Global Lyme Alliance Gala in New York City on Thursday, and told the audience her children were diagnosed over three years ago. (Source: the Mail online | Health)


Friday 9 October 2015

Yolanda Foster reveals her model daughter Bella, 18, and son Anwar, 16, both also have Lyme disease at charity gala

The 51-year-old reality star was honoured at the Global Lyme Alliance Gala in New York City on Thursday, and told the audience her children were diagnosed over three years ago. (Source: the Mail online | Health)


Friday 9 October 2015

Vesicular erythema migrans: an atypical and easily misdiagnosed form of Lyme disease.

Authors: Mazori DR, Orme CM, Mir A, Meehan SA, Neimann AL Abstract Erythema migrans is the initial sign in the majority of patients infected with Borrelia, the genus of spirochetes that causes Lyme disease. Early identification and treatment decrease the risk of progression to later stages of disease. Although a "bull's eye" appearance owing to lesional clearing is considered classic for erythema migrans, this feature is surprisingly often lacking among patients in the United States. Furthermore, cutaneous Lyme disease can exhibit a wide range of morphologic variability in a minority of patients. Herein, we describe the case of a patient with Lyme disease in which the presence of atypical vesicular features, in conjunction with the initial absence of clearing, resulted in multiple ...

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Friday 9 October 2015

Poor Positive Predictive Value of Lyme Disease Serologic Testing in an Area of Low Disease Incidence

Conclusions. In this low-prevalence cohort, fewer than 20% of positive Lyme disease tests are obtained from patients with clinically likely Lyme disease. Positive Lyme disease test results may have little diagnostic value in this setting. (Source: Clinical Infectious Diseases)



Thursday 8 October 2015

Molecular detection of Anaplasma phagocytophilum and Borrelia burgdorferi sensu lato genospecies in red foxes (Vulpes vulpes) from Romania

Conclusion: This first report of A. phagocytophilum and B. burgdorferi s.l. in red foxes from Romania suggests a limited role of foxes in the maintenance of the two related pathogens, but may represent a potential risk from a public health perspective. (Source: Parasites and Vectors)


Tuesday 6 October 2015

[Review] Emerging tick-borne infections in mainland China: an increasing public health threat

Since the beginning of the 1980s, 33 emerging tick-borne agents have been identified in mainland China, including eight species of spotted fever group rickettsiae, seven species in the family Anaplasmataceae, six genospecies in the complex Borrelia burgdorferi sensu lato, 11 species of Babesia, and the virus causing severe fever with thrombocytopenia syndrome. In this Review we have mapped the geographical distributions of human cases of infection. 15 of the 33 emerging tick-borne agents have been reported to cause human disease, and their clinical characteristics have been described. (Source: The Lancet Infectious Diseases)


Saturday 3 October 2015

'Like the Caudwells, our family also has Lyme disease'

Adelle Huckins believes her husband and children have contracted the illness from her after John Caudwell said he passed the illness on to his children (Source: Telegraph Health)


Saturday 3 October 2015

Lyme Disease Presenting as a Spontaneous Knee Effusion.

Authors: Matzkin E, Suslavich K, Curry EJ Abstract Musculoskeletal complaints, which are frequently associated with Lyme disease, often prompt patients to see a physician. In particular, transient episodes of spontaneous knee effusion are common early in the progression of Lyme disease, and, if left untreated, 60% of patients diagnosed with the disease develop Lyme arthritis. This disease is easily treated with antibiotics; therefore, inclusion of Lyme disease in the differential diagnosis as a potential cause of a spontaneous knee effusion can prevent the development of more severe symptoms associated with the disease. However, the time required to receive test results and the inconsistencies between serum and synovial tests can complicate diagnosis of the disease. PMID: 26416...


Friday 2 October 2015

#InvisibleIllnessWeek Is Over -- What Happens Now?

Social media has been taken over by #InvisibleIllnessWeek. Almost everyone has seen a tweet there or a status update here referring to it, and as awesome as it has been in generating interest in a topic that doesn't often surface in everyday media, the conversations it has given rise to deviate into two extremes: either showcasing the horrible aspects of living with a chronic diagnosis or an all-encompassing positivity celebrating invisible illnesses. First of all, what IS an invisible illness? It's a diagnosis that often doesn't show itself on the surface, most of them are autoimmune conditions such as Lyme disease, Crohn's disease, etc. The reason they are so hard to track and represent is because they are so dispersed despite affecting literally millions of people around the world. Als...

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Friday 2 October 2015

What is Lyme disease? The silent killer affecting over 3000 Brits a year

AVRIL LAVIGNE is a celebrity sufferer, but Lyme disease is no joke - there's 3,000 new cases occurring in the UK every year, but do you know what it is? (Source: Daily Express - Health)


Friday 2 October 2015

No Geographic Correlation between Lyme Disease and Death due to 4 Neurodegenerative Disorders, United States, 2001–2010

J. D. Forrester et al. (Source: Emerging Infectious Diseases Journal)

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Thursday 1 October 2015

Why I’m thankful for my daughter’s MRSA

“What time is surgery today?” Ellie, age 12, croaks. She hasn’t opened her eyes yet, but she knows she’s headed to the operating room … again. It may be the fourth surgery this month, maybe the fifth. We don’t know. What we do know is our routine has changed from soccer carpools and homework battles to twice-weekly trips to the operating room, where the orthopedic surgeon will slice open my baby girl’s thigh and attempt to wash out the deadly bacteria accumulating in her right femur and knee joint. We’re trying to learn the new routine and master a new language. The vocabulary is demanding. There are procedures, medications, devices and acronyms. Most are scary — wound vacuum, PICC (peripherally inserted central catheter), clinical failure of vancomycin, Methicillin-resis...


Thursday 1 October 2015

In vitro evaluation of antibacterial activity of phytochemicals and micronutrients against Borrelia burgdorferi and Borrelia garinii

ConclusionsThe most effective antimicrobial compounds against all morphological forms of the two tested Borrelia sp. were baicalein and monolaurin. This might indicate that the presence of fatty acid and phenyl groups is important for comprehensive antibacterial activity. Significance and Impact of the StudyThis study reveals the potential of phytochemicals as an important tool in the fight against the species of Borrelia causing Lyme disease.This article is protected by copyright. All rights reserved. (Source: Journal of Applied Microbiology)


Thursday 1 October 2015

Lyme Carditis in the Fast Lane: From Alternating Bundle Branch Block to Asystole in 12 Hours.

We report a case of Lyme disease in a previously healthy 24-year-old male presenting with alternating right- and left-bundle branch block, indicating infra-Hisian atrioventricular (infra-His) block with an accelerated fascicular escape rhythm. Inless than 12 hours, the conduction abnormalities progressed to asystole requiring the urgent placement of a temporary transvenous pacemaker. Subsequently, with appropriate antibiotic treatment, the patient's conduction abnormalities resolved in a week without the need for a permanent pacemaker. PMID: 26630701 [PubMed - in process] (Source: Connecticut Medicine)


Monday 28 September 2015

Similarities in murine infection and immune response to Borrelia bissettii and Borrelia burgdorferi sensu stricto.

Authors: Leydet BF, Liang FT Abstract Three decades ago Borrelia burgdorferi sensu stricto (ss) was identified as the etiologic agent of Lyme disease. Since then an increasing number of Borrelia burgdorferi sensu lato (sl) species have been isolated in the United States. To date, many of these species remain understudied despite mounting evidence associating them with human illness. Borrelia bissettii is a spirochete closely related to B. burgdorferi that has been loosely associated with human illness. Using an experimental murine infection model, we compared the infectivity and humoral immune response to a North American isolate of B. bissettii and B. burgdorferi using culture, molecular and serological methods. Our original B. bissettii cultures were unable to infect immunocompet...


Saturday 26 September 2015

Epidemiology of Lyme Disease, Nova Scotia, Canada, 2002-2013.

Authors: Hatchette TF, Johnston BL, Schleihauf E, Mask A, Haldane D, Drebot M, Baikie M, Cole TJ, Fleming S, Gould R, Lindsay R Abstract Ixodes scapularis ticks, which transmit Borrelia burgdorferi, the causative agent of Lyme disease (LD), are endemic to at least 6 regions of Nova Scotia, Canada. To assess the epidemiology and prevalence of LD in Nova Scotia, we analyzed data from 329 persons with LD reported in Nova Scotia during 2002-2013. Most patients reported symptoms of early localized infection with rash (89.7%), influenza-like illness (69.6%), or both; clinician-diagnosed erythema migrans was documented for 53.2%. In a separate serosurvey, of 1,855 serum samples screened for antibodies to B. burgdorferi, 2 were borderline positive (both with an indeterminate IgG on Western...


Saturday 26 September 2015

Structural and functional analysis of BB0689 from Borrelia burgdorferi, a member of the bacterial CAP superfamily

In this study, the bacterial CAP domain structure was analyzed and compared with the previously solved crystal structures of representative CAPs, and the function of BB0689 was examined. To determine the potential function of BB0689 and ascertain whether the functions that have been attributed to the CAP domain proteins are conserved, the binding of previously reported CAP domain interaction partners was analyzed, and the results suggested that BB0689 has a unique function that is yet to be discovered. (Source: Journal of Structural Biology)

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Saturday 26 September 2015

Quality of life, fatigue, depression and cognitive impairment in Lyme neuroborreliosis

Abstract The prognosis and impact of residual symptoms on quality of life in patients with Lyme neuroborreliosis (LNB) is subject to debate. The aim of this study was to assess quality of life, fatigue, depression, cognitive impairment and verbal learning in patients with definite LNB and healthy controls in a case–control study. We retrospectively identified all patients diagnosed with definite LNB between 2003 and 2014 in our tertiary care center. Healthy controls were recruited from the same area. Patients and healthy controls were assessed for quality of life [Short Form (36) with subscores for physical and mental components (PCS, MCS)], fatigue (fatigue severity scale), depression (Beck depression inventory), verbal memory and learning and cognitive impairment (mini-mental ...


Friday 25 September 2015

Patients may present with ticks in South London A&Es

Nurses working in emergency and primary care settings in South London could encounter patients with Lyme disease-carrying ticks, suggests latest research. (Source: Nursing Times Breaking News)


Friday 25 September 2015

Identification and the preliminary in vitro characterization of IRIS homologue from salivary glands of Ixodes persulcatus Schulze

In conclusion, Ipis could contribute to the establishment of environments suitable for tick blood feeding and pathogen transmission by suppressing the function of immune cells. (Source: Ticks and Tick borne Diseases)


Thursday 24 September 2015

Ticks carrying Lyme disease found in South London parks

(London School of Hygiene & Tropical Medicine) Visitors to two popular parks in South London are at risk of coming into contact with ticks that can transmit Lyme disease to humans, according to new research by the London School of Hygiene & Tropical Medicine. (Source: EurekAlert! - Infectious and Emerging Diseases)


Thursday 24 September 2015

Researchers find ticks linked with Lyme disease in south London parks

(Wiley) Visitors to two popular parks in South London are at risk of coming into contact with ticks that can transmit Lyme disease to humans, according to a new study in Medical and Veterinary Entomology. (Source: EurekAlert! - Infectious and Emerging Diseases)

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Thursday 24 September 2015

Ecology and Epidemiology of Lyme Borreliosis

Lyme borreliosis is a zoonotic, tick-borne disease that infects humans worldwide. The disease is currently recognized as the most common vector-borne disease in Europe and North America. Disease is caused by several genospecies of the Borrelia burgdorferi sensu lato complex. Humans are at high risk of infection in regions where highly competent reservoirs are the primary hosts for the subadult stages of the tick, in contrast to regions where less competent or refractory animals feed ticks. Human infections are also most frequently associated with spring and summer months when the nymph stage of the tick is active. (Source: Clinics in Laboratory Medicine)

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Thursday 24 September 2015

Clinical Manifestations and Treatment of Lyme Disease

Lyme disease is the most common tick-borne illness in the United States and is also seen in areas of Europe and Asia. The growing deer and Ixodes species tick populations in many areas underscore the importance of clinicians to properly recognize and treat the different stages of Lyme disease. Controversy regarding the cause and management of persistent symptoms following treatment of Lyme disease persists and is highlighted in this review. (Source: Clinics in Laboratory Medicine)


Thursday 24 September 2015

Pathogens vectored by the tick, Dermacentor reticulatus, in endemic regions and zones of expansion in Poland

Conclusions: Our study found significant differences between the range and prevalence of vectored pathogens in D. reticulatus from the endemic areas and newly inhabited expansion zones. The differences were likely associated with the different time of settlement or ‘source’ of ticks populations, the Eastern and the Western one. (Source: Parasites and Vectors)


Wednesday 23 September 2015

Ericaceae in Post-Lyme Disease

Homoeopathic Links 2015; 28: 179-181DOI: 10.1055/s-0035-1563551Alex Leupen has been working in the Homeopathic Doctors Centre in Utrecht, the Netherlands, since 1990. Eight colleagues work in this centre, including Jan Scholten. Alex is an experienced teacher on the underlying systems in the plant families, nosodes, animal orders and the periodic table of the elements pertaining to homeopathic practice. He shares his clinical tips in this article.[...]Thieme Medical and Scientific Publishers Private Ltd. Article in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Homoeopathic Links)


Tuesday 22 September 2015

Lyme neuroborreliosis: a treatable cause of acute ocular motor disturbances in children

Conclusions LNB can present as acute ocular motor disorders in conjunction with fatigue and other clinical manifestations. In endemic areas, children with unexplained, acquired ocular motor abnormalities should be evaluated for LNB, a treatable medical condition. (Source: British Journal of Ophthalmology)


Monday 21 September 2015

An Update on the Hazards and Risks of Forensic Anthropology, Part II: Field and Laboratory Considerations.

Discussion of pathogen hazards (Brucella, Borrelia burgdorferi, Yersinia pestis, Clostridium tetani and West Nile virus) includes important history, exposure routes, environmental survivability, early symptoms, treatments with corresponding morbidity and mortality rates, and decontamination measures. Additionally, data pertaining to the use of formaldehyde in the laboratory environment have resulted in updated safety regulations, and these are highlighted. These data should inform field and laboratory protocols. The hazards of working directly with human remains are discussed in a companion article, "An Update on the Hazards and Risks of Forensic Anthropology, Part I: Human Remains." PMID: 26389711 [PubMed - as supplied by publisher] (Source: Journal of Forensic Sciences)


Saturday 19 September 2015

Exploratory spatial analysis of Lyme disease in Texas –what can we learn from the reported cases?

Conclusions: These results emphasize the need for follow-up investigations to determine whether the identified spatial pattern is due to: clustering of misdiagnosed cases, clustering of patients with an out-of state travel history, or presence of a clustered unknown enzootic cycle of B. burgdorferi in Texas. This would enable an improved surveillance and reporting of LD in Texas. (Source: BMC Public Health)


Thursday 17 September 2015

Disease

Borrelia miyamotoi disease (BMD) is a newly recognized borreliosis globally transmitted by ticks of the Ixodes persulcatus species complex. Once considered to be a tick symbiont with no public health implications, B miyamotoi is increasingly recognized as the agent of a nonspecific febrile illness often misdiagnosed as acute Lyme disease without rash, or as ehrlichiosis. The frequency of its diagnosis in the northeastern United States is similar to that of human granulocytic ehrlichiosis. A diagnosis of BMD is confirmed by polymerase chain reaction analysis of acute blood samples, or by seroconversion using a recombinant glycerophosphodiester phosphodiesterase enzyme immunoassay. BMD is successfully treated with oral doxycycline or amoxicillin. (Source: Clinics in Laboratory Medicine)

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Thursday 17 September 2015

Nervous System Lyme Disease

Nervous system involvement occurs in 10% to 15% of patients infected with the tick-borne spirochetes Borrelia burgdorferi, B afzelii, and B garinii. Peripheral nervous system involvement is common. Central nervous system (CNS) involvement, most commonly presenting with lymphocytic meningitis, causes modest cerebrospinal fluid (CSF) pleocytosis. Parenchymal CNS infection is rare. If the CNS is invaded, however, measuring local production of anti–B burgdorferi antibodies in the CSF provides a useful marker of infection. Most cases of neuroborreliosis can be cured with oral doxycycline; parenteral regimens should be reserved for patients with particularly severe disease. (Source: Clinics in Laboratory Medicine)


Wednesday 16 September 2015

Meningomyeloradiculitis as an Unusual Presentation of Neuroborreliosis in Childhood

We report a pediatric case of Lyme neuroborreliosis–associated meningomyeloradiculitis with atypical manifestations and negative initial cerebrospinal fluid borrelial antibodies. Transverse myelitis and painful radiculoneuritis have rarely been described in pediatric neuroborreliosis. Clinical manifestations are wide ranging and nonspecific, and the serologic diagnosis is often delayed in the acute phase. (Source: The Pediatric Infectious Disease Journal)


Wednesday 16 September 2015

Azithromycin Is Equally Effective as Amoxicillin in Children with Solitary Erythema Migrans

Conclusions: Comparison of azithromycin and amoxicillin for the treatment of children with solitary EM revealed comparable efficacy and adverse effects of treatment. (Source: The Pediatric Infectious Disease Journal)


Wednesday 16 September 2015

Cross-reactive acquired immunity influences transmission success of the Lyme disease pathogen, Borrelia afzelii.

This study shows that cross-immunity in infected vertebrate hosts can reduce pathogen load in the arthropod vector with potential consequences for vector-to-host pathogen transmission. PMID: 26384476 [PubMed - as supplied by publisher] (Source: Infection, Genetics and Evolution)


Wednesday 16 September 2015

Nervous system Lyme disease, chronic Lyme disease, and none of the above

Abstract Lyme borreliosis, infection with the tick-borne spirochete Borrelia burgdorferi sensu lato, causes nervous system involvement in 10–15 % of identified infected individuals. Not unlike the other well-known spirochetosis, syphilis, infection can be protracted, but is microbiologically curable in virtually all patients, regardless of disease duration. Diagnosis relies on 2-tier serologic testing, which after the first 4–6 weeks of infection is both highly sensitive and specific. After this early, acute phase, serologic testing should rely only on IgG reactivity. Nervous system involvement most commonly presents with meningitis, cranial neuritis and radiculoneuritis, but can also present with a broader array of peripheral nervous system manifestations. Central nervous sy...


Wednesday 16 September 2015

Evaluation of selected Borrelia burgdorferi lp54 encoded gene products expressed during mammalian infection as antigens to improve serodiagnostic testing for early Lyme disease.

Authors: Weiner ZP, Crew RM, Brandt KS, Ullmann AJ, Schriefer ME, Molins CR, Gilmore RD Abstract Laboratory testing for the diagnosis of Lyme disease is performed primarily by serologic assays and is accurate for detection beyond the acute stage of the infection. Serodiagnostic assays to detect the early stages of infection, however, are limited in their sensitivity and improvement is warranted. We analyzed a series of Borrelia burgdorferi proteins known to be induced either within feeding ticks and/or during mammalian infection for their utility as serodiagnostic markers against a comprehensive panel of Lyme disease patient serum samples. The antigens were assayed for IgM and IgG reactivity in line immunoblots and separately by ELISA, with a focus on reactivity against early Lyme ...

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Tuesday 15 September 2015

Borrelia burgdorferi HtrA: evidence for two‐fold proteolysis of outer membrane protein p66

Summary In prokaryotes, members of the High Temperature Requirement A (HtrA) family of serine proteases function in the periplasm to degrade damaged or improperly folded membrane proteins. Borrelia burgdorferi, the agent of Lyme disease, codes for a single HtrA homolog. Two‐dimensional electrophoresis analysis of B. burgdorferi B31A3 and a strain that over‐expresses HtrA (A3HtrAOE) identified a down‐regulated protein in A3HtrAOE with a mass, pI and MALDI‐TOF spectrum consistent with outer membrane protein p66. P66 and HtrA from cellular lysates partitioned into detergent‐resistant membranes, which contain cholesterol‐glycolipid‐rich membrane regions known as lipid rafts, suggesting that HtrA and p66 may reside together in lipid rafts also. This agrees with previous work from ...


Monday 14 September 2015

Tickborne Infections: Beyond Just Lyme Disease

Members of the Borrelia genus are associated with two main clinical syndromes: Lyme borreliosis and relapsing fever. With a few exceptions, these spirochetes share many similarities, including transmission via blood feeding arthropods, environmental maintenance among rodent populations, and interruption of the lifecycle following human infection. As a result of the high annual incidence of Lyme disease in both the United States (approximately 300,000 cases) and Europe (approximately 85,000 cases from 18 countries), Lyme borreliosis and its causative agents (primarily Borrelia burgdorferi in the United States and Borrelia afzelii and Borrelia garinii in Europe) often garner the most attention from both the medical community and public forums. (Source: Clinics in Laboratory Medicine)


Saturday 12 September 2015

Isolated facial diplegia in Guillain–Barré syndrome: Bifacial weakness with paresthesias

ABSTRACT Bifacial weakness with paresthesias (BFP) is a subtype of Guillain–Barré syndrome defined by rapidly progressive bilateral facial weakness in the absence of other cranial neuropathies, ataxia, or limb weakness. Many patients also complain of distal limb paresthesias and display diminished or absent deep tendon reflexes. BFP is a localized form of Guillain–Barré syndrome and is thought to be caused exclusively by demyelinating‐ rather than axonal‐type neuropathy. Patients with BFP do not display anti‐ganglioside IgG antibodies. Since it is rare, many physicians are unfamiliar with BFP, as bilateral facial weakness is more commonly associated with sarcoidosis, Lyme disease, or meningeal pathology. Many patients diagnosed with bilateral Bell palsy may instead have BFP. In...


Friday 11 September 2015

'Lab-on-a-Chip' technology to cut costs of sophisticated tests for diseases and disorders

Engineers have developed a breakthrough device that can significantly reduce the cost of sophisticated lab tests for medical disorders and diseases, such as HIV, Lyme disease and syphilis. The new device uses miniaturized channels and valves to replace 'benchtop' assays -- tests that require large samples of blood or other fluids and expensive chemicals that lab technicians manually mix in trays of tubes or plastic plates with cup-like depressions. (Source: ScienceDaily Headlines)


Friday 11 September 2015

American Black Bears as Hosts of Blacklegged Ticks (Acari: Ixodidae) in the Northeastern United States

Ticks and whole blood were collected from American black bears (Ursus americanus Pallas) between October 2011 and October 2012 across four counties in northwestern New Jersey, an area where blacklegged ticks (Ixodes scapularis Say) and their associated tick-borne pathogens are prevalent. Adult American dog ticks (Dermacentor variabilis Say) were the most frequently collected tick species in late spring, whereas adult and nymphal blacklegged ticks were found in both the late spring and fall months. Additionally, for blacklegged ticks, we determined the quality of bloodmeals that females acquired from black bears compared with bloodmeals from white-tailed deer (Odocoileus virginianus Zimmerman), the most important host for the adult stage of this tick species. Measures of fecundity after fee...

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Wednesday 9 September 2015

What Is Lyme disease and why the controversy?

(NaturalNews) Lyme disease is no longer an obscure malady that can only be caught in Connecticut. In 2013, the year with the latest available data, the CDC predicted an estimated 300,000 actual new cases, though only 30,000 per year were reported and confirmed. Cases have been diagnosed... (Source: NaturalNews.com)


Wednesday 9 September 2015

Tricky ticks: the importance of Lyme carditis recognition.

Authors: Jansweijer JA, van Oort RJ PMID: 26353768 [PubMed - as supplied by publisher] (Source: Netherlands Heart Journal)


Wednesday 9 September 2015

General practitioner reported incidence of Lyme carditis in the Netherlands.

CONCLUSIONS: We report the first incidence estimate for Lyme carditis in the Netherlands, validated by a systematic review of the medical records. Although Lyme carditis is an uncommon manifestation of Lyme borreliosis, physicians need to be aware of this diagnosis, in particular in countries where the incidence of Lyme borreliosis has increased during the past decades. PMID: 26353767 [PubMed - as supplied by publisher] (Source: Netherlands Heart Journal)


Tuesday 8 September 2015

Lyme law: targeting best practices.

Authors: Patrick DM PMID: 26351367 [PubMed - in process] (Source: cmaj)


Monday 7 September 2015

8 illnesses you could have brought back from holiday

From Lyme disease in Scotland to Chikungunya from the Caribbean, a list of common ailments you could have contracted during your week away (Source: Telegraph Health)


Monday 7 September 2015

Cerebrospinal Fluid Cytology of Lyme Neuroborreliosis: A Report of 3 Cases with Literature Review

We present 3 Lyme neuroborreliosis cases in order to illustrate the challenging cytomorphological and immunophenotypic features of their CSF specimens. Three male patients who presented with central nervous system manifestations were diagnosed with Lyme disease. The clinical presentation, laboratory tests, CSF cytological examination and flow-cytometric studies were described for each case. CSF cytology showed lymphocytic pleocytosis with increased plasmacytoid cells and/or plasma cells. Flow cytometry showed the presence of polytypic B lymphocytes with evidence of plasmacytic differentiation in 2 cases. In all cases, Lyme disease was confirmed by the Lyme screening test and Western blotting. In such cases of Lyme neuroborreliosis, flow cytometry of CSF samples employing plasmacytic marker...


Saturday 5 September 2015

Lyme Disease Diagnosed by Alternative Methods: A Phenotype Similar to That of Chronic Fatigue Syndrome

Conclusions. In British Columbia, a setting with low Lyme disease incidence, ADCLS patients have a similar phenotype to that of CFS patients. Disagreement between alternative and reference laboratory Lyme testing results in this setting is most likely explained by false-positive results from the alternative laboratory. (Source: Clinical Infectious Diseases)

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Saturday 5 September 2015

Lyme Disease Comparators

(Source: Clinical Infectious Diseases)


Friday 4 September 2015

Lyme Deaths From Heart Inflammation Likely Worse Than We Thought

Lyme disease and other tick-borne infections are skyrocketing. In western Pennsylvania, where I work, Lyme increased 25% just between 2013 and 2014, with Butler County having 412 cases and Allegheny County chalking up a record 822 cases last year. And where I vacation, in Maine, the rate of Lyme in 2014 was 240 cases per 100,000, which is more than 20 times the national average, and twice the rate of Butler. Across the country, the CDC now estimates there are ~329,000 cases of Lyme disease each year, tenfold higher than previously thought. Vermont and New Hampshire have the highest incidence. (Source: Forbes.com Healthcare News)

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Friday 4 September 2015

Abundance of questing ticks and molecular evidence for pathogens in ticks in three parks of Emilia-Romagna region of Northern Italy.

DISCUSSION: The peak of nymph presence was in May, and the higher prevalence of pathogens occurred in April-June, most often in nymphs; therefore, spring season could represent the higher risk period for the transmission of pathogens. These data could provide guidelines for the preventions of tick-trasmitted diseases in this region. PMID: 26403115 [PubMed - in process] (Source: Annals of Agricultural and Environmental Medicine : AAEM)


Friday 4 September 2015

Clinical and molecular features of one case of human infection with Anaplasma phagocytophilum from Podlaskie Province in eastern Poland.

Authors: Welc-Falęciak R, Kowalec M, Zajkowska J, Pancewicz SA, Siński E Abstract The article focuses on the clinical and laboratory diagnosis of human granulocytic anaplasmosis (HGA) caused by Anaplasma phagocytophilum infection in one of 28 patients (3.6%; n=1/28 tested samples) with early Lyme borreliosis. The clinical and laboratory results of a 42-year-old patient fulfilled criteria of confirm anaplasmosis and suggest an acute stage of illness. The described case provides strong presumptive evidence that infection in this patient was acquired with a pathogenic strain of A. phagocytophilum through a tick bite. A positive DNA with PCR for A. phagocytophilum infection was sequenced and analyzed phylogenetically. Physicians should consider the possibility of anaplasmosis in pati...


Friday 4 September 2015

A broad-range survey of ticks from livestock in Northern Xinjiang: changes in tick distribution and the isolation of Borrelia burgdorferi sensu stricto

Conclusions: Warmer and wetter climate may have contributed to the altered distribution and abundance of the five most common ticks in northern Xinjiang. The genetic analyses showed that certain tick species, such as Hy. asiaticum or Rh. turanicus, exhibit genetic commonness or diversity. Additionally, this study is the first to isolate B. burgdorferi sensu stricto in Hy. asiaticum asiaticum, H. punctata, D. nuttalli and D. marginatus ticks from domestic animals. These ticks may transmit borreliosis among livestock. (Source: Parasites and Vectors)


Friday 4 September 2015

ER-Coordinated Activities of Rab22a and Rab5a Drive Phagosomal Compaction and Intracellular Processing of Borrelia burgdorferi by Macrophages

Publication date: Available online 3 September 2015 Source:Cell Reports Author(s): Xenia Naj, Stefan Linder Borrelia burgdorferi is the causative agent of Lyme disease, a multisystemic disorder affecting the skin, joints, and nervous system. Macrophages and dendritic cells counteract Borrelia dissemination through internalization and degradation of spirochetes. We now show that Borrelia internalization by primary human macrophages involves uptake and compaction into Rab22a-positive phagosomes that are in close contact with Rab5a-positive vesicles. Compaction of borreliae involves membrane extrusion from phagosomes, is driven by Rab22a and Rab5a activity, and is coordinated by ER tubules forming contact sites of Rab22a phagosomes with Rab5a vesicles. Importantly, Rab22a and Rab5a deplet...


Friday 4 September 2015

Peroxidative metabolism of arachidonic acid in the course of Lyme arthritis.

CONCLUSIONS: It may be suggested that in the course of LA, the level of binding 8-isoPGF2α is significantly enhanced, and it may also be suggested that uncontrolled changes in the lipid status of some patients may make their Lyme arthritis unresponsive to antibiotics. PMID: 26403109 [PubMed - in process] (Source: Annals of Agricultural and Environmental Medicine : AAEM)

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Wednesday 2 September 2015

A 35-year-old man with a positive Lyme test result from a private laboratory.

Authors: Andany N, Cardew S, Bunce PE PMID: 26323702 [PubMed - as supplied by publisher] (Source: Canadian Medical Association Journal)


Wednesday 2 September 2015

Lyme disease: How reliable are serologic results?

Authors: Gregson D, Evans G, Patrick D, Bowie W PMID: 26323708 [PubMed - as supplied by publisher] (Source: Canadian Medical Association Journal)


Wednesday 2 September 2015

Borrelia burgdorferi elongation factor EF-Tu is an immunogenic protein during Lyme borreliosis

Authors: Sebastian E Carrasco, Youyun Yang, Bryan Troxell, Xiuli Yang, Utpal Pal & X Frank Yang (Source: Emerging Microbes and Infections)

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Wednesday 2 September 2015

Persister mechanisms in Borrelia burgdorferi: implications for improved intervention

Authors: Jie Feng, Wanliang Shi, Shuo Zhang & Ying Zhang (Source: Emerging Microbes and Infections)


Tuesday 1 September 2015

How to rid the body of Lyme disease naturally

(NaturalNews) The bacteria that cause Lyme can be found in the skin, heart, joints, and nervous system. On top of that, Lyme disease specialists are finding that what we call Lyme disease may be caused by several different infectious organisms and may even be caused by a combination... (Source: NaturalNews.com)


Tuesday 1 September 2015

Lyme Arthritis

No abstract available (Source: Pediatric Emergency Care)


Tuesday 1 September 2015

Transfusion-Transmitted Babesiosis During Total Hip Arthroplasty.

This article summarizes the current state of transfusion-transmitted babesiosis and the detrimental impact of this infection on blood transfusion safety. [Orthopedics. 2015; 38(9):e852-e855.]. PMID: 26375547 [PubMed - in process] (Source: Orthopedics)


Tuesday 1 September 2015

Tick abundances in South London parks and the potential risk for Lyme borreliosis to the general public

Abstract Tick abundances and prevalences of infection with Borrelia burgdorferi sensu lato, the causative agent of Lyme disease, were investigated in four South London parks. A total of 360 transects were sampled using three methods of collection (blanket, leggings and flags) simultaneously. No ticks were found on Wimbledon Common or at Hampton Court, but 1118 Ixodes ricinus (Ixodida: Ixodidae) ticks were collected at Richmond and Bushy Parks. At Richmond Park, lower canopy humidity [odds ratio (OR) 0.94; P = 0.005], increased mat depth (OR 1.15; P < 0.001) and increased soil moisture (OR 1.40; P = 0.001) predicted the presence of I. ricinus, and increased sward height [incidence rate ratio (IRR) 1.01; P = 0.006] and decreased ground temperature (IRR 0.90; P = 0.009) predicted increased...


Tuesday 1 September 2015

BadR (BB0693) controls growth phase‐dependent induction of rpoS and bosR in Borrelia burgdorferi via recognizing TAAAATAT motifs

Summary In Borrelia burgdorferi (Bb), the alternative sigma factor RpoS plays a central role during Bb's adaptation to ticks and mammals. Previous studies have demonstrated that RpoS is not expressed during the early stages of spirochetal growth or when Bb resides in ticks during the intermolt phase, but the molecular details of these events remain unknown. In the current study, biomagnetic bead separation of rpoS promoter‐binding proteins, coupled with genetic inactivation, was employed to identify BadR (BB0693) as a negative regulator that controls growth phase‐dependent induction of rpoS and bosR in Bb. When badR was inactivated, the expression of rpoS and bosR was induced only during the early stages of bacterial growth, but not during the stationary growth phase. Recombinant BadR ...


Monday 31 August 2015

A Presentation of Lyme Disease: Pseudotumor Cerebri.

Authors: Şahin B, İncecik F, Hergüner ÖM, Alabaz D, Beşen Ş Abstract Lyme disease is caused by a tick-transmitted spirochete, B. burgdorferi. It can present with both central and peripheral nervous system manifestations, including aseptic meningitis, meningoencephalitis, Bell's palsy and other cranial neuropathies, radiculoneuritis, and myelitis. However, pseudotumor cerebri associated with Lyme disease is rare. Here, we report a eight-year-old girl with the unusual manifestation of pseudotumor cerebri associated Lyme disease. PMID: 27411423 [PubMed - in process] (Source: The Turkish Journal of Pediatrics)

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Monday 31 August 2015

Staffordshire mother loses FOUR STONE after seeing herself in Ice Bucket Challenge video

Louise Bentley, 47, an admin assistant from Newcastle-under-Lyme, Staffordshire, slimmed from 15st 5lb to a trim 11st 4lb in less than a year after swapping junk food for healthy meals. (Source: the Mail online | Health)


Monday 31 August 2015

Lyme disease testing: Canadians may receive false-positives from some US labs

Lyme disease is becoming increasingly common in Canada, and Canadians with Lyme disease symptoms may seek diagnoses from laboratories in the United States, although many of the results will be false-positives, according to a new commentary article. (Source: ScienceDaily Headlines)


Monday 31 August 2015

Epidemiology of Lyme Disease, Nova Scotia, Canada, 2002–2013

T. F. Hatchette et al. (Source: Emerging Infectious Diseases Journal)


Monday 31 August 2015

Lyme Disease Coinfections in the United States

Lyme disease in North America is caused by infection with the spirochetal bacterium Borrelia burgdorferi and transmitted by Ixodes scapularis and Ixodes pacificus ticks. These ticks also have the potential to transmit a rapidly expanding list of other pathogenic bacteria, viruses, and parasites, including Anaplasma phagocytophilum, Babesia microti, deer tick (Powassan) virus, Borrelia miyamotoi, and the Ehrlichia muris–like organism. Coinfections with B burgdorferi and these other agents are often difficult to diagnose and may go untreated, and thus contribute significantly to patient morbidity and mortality from tick-borne infections. (Source: Clinics in Laboratory Medicine)


Monday 31 August 2015

Alternatives to Serologic Testing for Diagnosis of Lyme Disease

Although serologic testing remains the gold standard for laboratory diagnosis of Lyme disease, the antibody response may take several weeks to increase greater than the limit of detection. Because of this extended time frame, it is necessary to identify new diagnostic methods for earlier diagnosis and appropriate treatment of Lyme disease. Alternative diagnostic modalities, such as Borrelia culture or nucleic acid amplification testing, may be beneficial in specific clinical scenarios. In early phases of acute infection, before the development of an immune response, detection of Borrelia DNA from clinical specimens may help establish the diagnosis sooner than serologic methods. (Source: Clinics in Laboratory Medicine)


Monday 31 August 2015

Absence of sodA Increases the Levels of Oxidation of Key Metabolic Determinants of Borrelia burgdorferi

This study, utilizing the sodA mutant, has provided insights into adaptive capabilities critical for survival of B. burgdorferi in its hosts. (Source: PLoS One)


Saturday 29 August 2015

Lyme disease/borreliosis as a systemic disease

Lyme disease/borreliosis (LD) is a well-known arthropod-transmitted entity in the northern hemisphere. The incidence of LD is reportedly rising throughout the world, although better diagnostic facilities may be contributory. The disease distribution is expanding in Europe, with its presence being now documented at higher altitudes and latitudes. Borrelia burgdorferi sensu lato is the most important genospecies leading to LD, although newer ones continue to be discovered. The variations in clinical spectrum with genospecies involved are an interesting feature. (Source: Clinics in Dermatology)

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Saturday 29 August 2015

Structural characterization and modeling of the Borrelia burgdorferi hybrid histidine kinase Hk1 periplasmic sensor: a system for sensing small molecules associated with tick feeding

Publication date: Available online 28 August 2015 Source:Journal of Structural Biology Author(s): William J. Bauer, Amit Luthra, Guangyu Zhu, Justin D. Radolf, Michael G. Malkowski, Melissa J. Caimano Two-component signal transduction systems are the primary mechanisms by which bacteria perceive and respond to changes in their environment. The Hk1/Rrp1 two-component system (TCS) in B. burgdorferi consists of a hybrid histidine kinase and a response regulator with diguanlyate cyclase activity, respectively. Phosphorylated Rrp1 catalyzes the synthesis of c-di-GMP, a second messenger associated with bacterial life-style control networks. Spirochetes lacking either Hk1 or Rrp1 are virulent in mice but destroyed within feeding ticks. Activation of Hk1 by exogenous stimuli represents the...


Friday 28 August 2015

Isolated facial diplegia in Guillain‐Barré syndrome: Bifacial weakness with paresthesias

This article is protected by copyright. All rights reserved. (Source: Muscle and Nerve)


Friday 28 August 2015

Lyme Disease

The answer key for this puzzle is available online. (Source: The Journal for Nurse Practitioners)


Friday 28 August 2015

IJERPH, Vol. 12, Pages 10536-10548: Spatial and Spatio-Temporal Models for Modeling Epidemiological Data with Excess Zeros

Epidemiological data often include excess zeros. This is particularly the case for data on rare conditions, diseases that are not common in specific areas or specific time periods, and conditions and diseases that are hard to detect or on the rise. In this paper, we provide a review of methods for modeling data with excess zeros with focus on count data, namely hurdle and zero-inflated models, and discuss extensions of these models to data with spatial and spatio-temporal dependence structures. We consider a Bayesian hierarchical framework to implement spatial and spatio-temporal models for data with excess zeros. We further review current implementation methods and computational tools. Finally, we provide a case study on five-year counts of confirmed cases of Lyme disease in Illinois at t...

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Thursday 27 August 2015

Why antibiotics may not work for Lyme disease

(NaturalNews) For some, early treatment with antibiotics is effective. For others and for those in the late stages of infection, antibiotics may be ineffective for the following reasons:Borrelia burgdorferi, the bacteria that causes Lyme disease, has a corkscrew shape that allows... (Source: NaturalNews.com)

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Thursday 27 August 2015

Characterization Through Multilocus Sequence Analysis of Borrelia turdi Isolates from Portugal.

In this study, we isolated B. turdi from five I. frontalis feeding on Turdus merula, Turdus philomelos, Parus major and Troglodytes troglodytes, and one Ixodes ricinus feeding on a T. merula in Portugal. These isolates were genetically characterised according to their 5S-23S rRNA intergenic spacer, 16S rRNA and through typing of seven housekeeping genes (multilocus sequence typing). Multilocus sequence analyses revealed that the strains isolated in our study, although belonging to B. turdi genospecies, are not identical to the B. turdi reference strain Ya501. Instead, our strains are separated into a clear defined group, suggesting that the European samples diverged genetically from the strain originally detected in Japan. Population analysis of 5S-23S rRNA sequences can further resolve su...




Thursday 27 August 2015

The Fur homologue BosR requires Arg39 to activate rpoS transcription in Borrelia burgdorferi and thereby direct spirochete infection in mice.

This study shows that BosR repressed synthesis of the long transcript while at the same time activating synthesis of the short transcript. How BosR does this is unclear. To address this, spirochetes were engineered to express either BosR or the naturally occurring variant BosRR39K. Mice became infected by the spirochetes expressing BosR but not by the spirochetes expressing BosRR39K. Furthermore, the spirochetes expressing BosR activated rpoS transcription during growth in culture whereas the spirochetes expressing BosRR39K did not. Thus, BosR's activation of rpoS transcription somehow involves Arg39. This arginine is highly conserved in other FUR proteins and therefore other FUR proteins may also require this arginine to function. PMID: 26318670 [PubMed - as supplied by publisher] (So...


Wednesday 26 August 2015

Ixodes tick saliva suppresses the keratinocyte cytokine response to TLR2/TLR3 ligands during early exposure to Lyme borreliosis

This article is protected by copyright. All rights reserved. (Source: Experimental Dermatology)

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Wednesday 26 August 2015

Methods to Prevent Tick Bites and Lyme Disease

Current approaches for prevention of tick bites, Lyme disease, and other tick-borne diseases are described. Particular attention is paid to 4 risk-reduction strategies: (i) avoiding risk areas; (ii) personal protective measures that reduce the risk of tick bites or transmission of the agent of Lyme disease, Borrelia burgdorferi; (iii) reducing the number of infected ticks in the environment; and (iv) use of prophylactic antibiotic treatments following a bite to prevent clinical Lyme disease. (Source: Clinics in Laboratory Medicine)


Sunday 23 August 2015

Transient synovitis of the hip: which investigations are truly useful?

CONCLUSION: Our results suggest that most investigations performed during the initial work-up in patients suspected transient synovitis of the hip are unnecessary and should routinely include only. PMID: 26295841 [PubMed - as supplied by publisher] (Source: Swiss Medical Weekly)


Sunday 23 August 2015

Incidence of Clinician-Diagnosed Lyme Disease, United States, 2005-2010.

Authors: Nelson CA, Saha S, Kugeler KJ, Delorey MJ, Shankar MB, Hinckley AF, Mead PS Abstract National surveillance provides important information about Lyme disease (LD) but is subject to underreporting and variations in practice. Information is limited about the national epidemiology of LD from other sources. Retrospective analysis of a nationwide health insurance claims database identified patients from 2005-2010 with clinician-diagnosed LD using International Classification of Diseases, Ninth Revision, Clinical Modification, codes and antimicrobial drug prescriptions. Of 103,647,966 person-years, 985 inpatient admissions and 44,445 outpatient LD diagnoses were identified. Epidemiologic patterns were similar to US surveillance data overall. Outpatient incidence was highest among...


Sunday 23 August 2015

Enhancing Lyme Disease Surveillance by Using Administrative Claims Data, Tennessee, USA.

Authors: Clayton JL, Jones SG, Dunn JR, Schaffner W, Jones TF Abstract Lyme disease is underreported in the United States. We used insurance administrative claims data to determine the value of such data in enhancing case ascertainment in Tennessee during January 2011-June 2013. Although we identified ≈20% more cases of Lyme disease (5/year), the method was resource intensive and not sustainable in this low-incidence state. PMID: 26291336 [PubMed - in process] (Source: Emerging Infectious Diseases)


Saturday 22 August 2015

Cutaneous Borreliosis With a T-Cell–Rich Infiltrate and Simultaneous Involvement by B-Cell Chronic Lymphocytic Leukemia With t(14;18)(q32;q21)

We report an unusual constellation in a patient with synchronously diagnosed B-CLL and Borrelia infection of skin presenting with a dense dermal T-cell–rich infiltrate masking specific leukemic infiltrates of neoplastic B cells in the context of B-CLL harboring t(14;18)(q32;q21). Specific cutaneous involvement by B-CLL was confirmed by the detection of t(14;18)(q32;q21) (BCL2–IGH) using FISH in neoplastic B cells within the skin infiltrates. Borrelia burgdorferi (sensu lato) DNA detected by nested polymerase chain reaction in the skin biopsy and serological findings proved Borrelia infection. Complete resolution of the cutaneous infiltrates was observed after antibiotic treatment. This case demonstrates that Borrelia infection of the skin may present with dense T-cell–rich infiltrate...

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Saturday 22 August 2015

A prospective study on the incidence of Borrelia burgdorferi sensu lato infection after a tick bite in Sweden and on the Åland Islands, Finland (2008-2009)

Publication date: Available online 22 August 2015 Source:Ticks and Tick-borne Diseases Author(s): Peter Wilhelmsson, Linda Fryland, Pontus Lindblom, Johanna Sjöwall, Clas Ahlm, Johan Berglund, Mats Haglund, Anna J. Henningsson, Peter Nolskog, Marika Nordberg, Clara Nyberg, Katharina Ornstein, Dag Nyman, Christina Ekerfelt, Pia Forsberg, Per-Eric Lindgren Lyme borreliosis (LB) is a common and increasing tick-borne disease in Europe. The risk of acquiring a Borrelia infection after a tick bite is not fully known. Therefore, we investigated the incidence of Borrelia infection after a bite by a Borrelia-infected tick and if the Borrelia load and/or the duration of tick-feeding influenced the risk of infection. During 2008-2009, ticks and blood samples were collected from 154...


Friday 21 August 2015

Sexual transmission of Lyme disease: challenging the tickborne disease paradigm

Expert Review of Anti-infective Therapy, Ahead of Print. (Source: Expert Review of Anti-Infective Therapy)


Wednesday 19 August 2015

Lyme Disease May Linger for 1 in 5 Because of "Persisters"

A new theory about long-lasting Lyme disease symptoms suggests treatment options -- Read more on ScientificAmerican.com (Source: Scientific American - Official RSS Feed)


Wednesday 19 August 2015

Persister mechanisms in Borrelia burgdorferi: implications for improved intervention

Authors: Jie Feng, Wanliang Shi, Shuo Zhang & Ying Zhang (Source: Emerging Microbes and Infections)


Monday 17 August 2015

How This Couple Fought Through Illness To Find A New Destiny

I am a caregiver for my partner who has become housebound and bedridden due to an incurable "invisible" disease. I too live with a serious illness, barely getting through each day, mostly housebound myself. Franky and I met, and a spell was cast; we fell madly deeply infatuated with each other, as young love often does to people. We traveled, went to social events and started dreaming of a life together. Within a couple of months, I was diagnosed with an aggressive strain of HIV. Our fast-run fairytale seemed to be cursed and destined for failure. But we persevered. My family's involvement in my life was scarce due to their struggles with me being a gay man. Luckily, Franky took the reins in helping me to fight for my life. Though we had just met, Franky cared for my body, fed me, and cl...


Friday 14 August 2015

Tick-ing Time Bomb: Lyme Disease Conquers New Territory

In the summer of 1975 a group of children who often played together developed an unusual flu-like illness with severe joint pain. They were diagnosed with Juvenile Rheumatoid Arthritis (JRA). All of them lived in a small town at the mouth of the Connecticut River called Lyme. The story of their disease contains all the elements of a good novel; mystery, loss, blood, empathy, indifference, conflict, controversy and conspiracy, truth and fiction. Doctors suspect JRA when they see kids with persistent joint pain or swelling, unexplained skin rashes, and fever associated with swelling of lymph nodes or inflammation of internal organs. No single test can be used to make the diagnosis. Both the cause and the cure of JRA, an autoimmune disorder, are unknown. But it is not an infectious disease. P...


Friday 14 August 2015

Defeat Lyme disease without antibiotics

(NaturalNews) Let's be blunt: Western medicine will never really cure Lyme disease because the focus (like everything they do) is on symptoms, not the underlying cause. In fact, sadly, if you've been suffering with Lyme disease for some time, you've probably been labeled with a mental... (Source: NaturalNews.com)




Wednesday 12 August 2015

Ticks: Summer’s Unwanted Guests

Thorough checks of spouses, children and friends for the tiny pathogen-carrying freeloaders are now a necessary part of summer rituals. (Source: NYT Health)


Wednesday 12 August 2015

Lyme disease is vastly under-reported, CDC says

Government researchers say the tick-borne disease is far more common than previously believed (Source: Health News: CBSNews.com)


Wednesday 12 August 2015

Lyme Disease in U.S. Is Under-Reported, CDC Says

About 329,000 cases actually occur each year (Source: WebMD Health)


Wednesday 12 August 2015

Incidence of Clinician-Diagnosed Lyme Disease, United States, 2005–2010

C. A. Nelson et al. (Source: Emerging Infectious Diseases Journal)

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Wednesday 12 August 2015

Borrelia burgdorferi RevA Significantly Affects Pathogenicity and Host Response in the Mouse Model of Lyme Disease [Bacterial Infections]

The Lyme disease spirochete, Borrelia burgdorferi, expresses RevA and numerous outer surface lipoproteins during mammalian infection. As an adhesin that promotes bacterial interaction with fibronectin, RevA is poised to interact with the extracellular matrix of the host. To further define the role(s) of RevA during mammalian infection, we created a mutant that is unable to produce RevA. The mutant was still infectious to mice, although it was significantly less well able to infect cardiac tissues. Complementation of the mutant with a wild-type revA gene restored heart infectivity to wild-type levels. Additionally, revA mutants led to increased evidence of arthritis, with increased fibrotic collagen deposition in tibiotarsal joints. The mutants also induced increased levels of the chemokine...


Wednesday 12 August 2015

BB0744 Affects Tissue Tropism and Spatial Distribution of Borrelia burgdorferi [Molecular Pathogenesis]

Borrelia burgdorferi, the etiologic agent of Lyme disease, produces a variety of proteins that promote survival and colonization in both the Ixodes species vector and various mammalian hosts. We initially identified BB0744 (also known as p83/100) by screening for B. burgdorferi strain B31 proteins that bind to α1β1 integrin and hypothesized that, given the presence of a signal peptide, BB0744 may be a surface-exposed protein. In contrast to this expectation, localization studies suggested that BB0744 resides in the periplasm. Despite its subsurface location, we were interested in testing whether BB0744 is required for borrelial pathogenesis. To this end, a bb0744 deletion was isolated in a B. burgdorferi strain B31 infectious background, complemented, and queried for the role of...


Wednesday 12 August 2015

Characterization and optimization of a novel vaccine for protection against Lyme borreliosis.

Authors: Comstedt P, Hanner M, Schüler W, Meinke A, Schlegl R, Lundberg U Abstract Lyme borreliosis (LB) is the most common vector-borne disease in the northern hemisphere and there is no vaccine available for disease prevention. The majority of LB cases in Europe are caused by four different Borrelia species expressing six different OspA serotypes, whereas in the US only one of these serotypes is present. Immunization with the outer surface protein A (OspA) can prevent infection and the C-terminal part of OspA is sufficient for protection against infection transmitted by Ixodes ticks. Here we show that the order of the stabilized monomeric OspA fragments making up the heterodimers in our LB vaccine does not influence the induced immunogenicity and protection. Using bioinformatics...


Wednesday 12 August 2015

Anaphylactoid reaction caused by sodium ceftriaxone in two horses experimentally infected by Borrelia burgdorferi

Conclusions: From the two cases presented here, it does appear that sodium ceftriaxone can induce anaphylactoid reactions in horses infected by Borrelia burgdorferi, which may evolve into colic syndrome, laminitis and the occurrence of opportunistic infections. However, further evidence should be collected in order to draw definite conclusions. (Source: BMC Veterinary Research)


Tuesday 11 August 2015

The Search for Persisters

Lyme disease–causing bacteria can outmaneuver antibiotics in vitro and manipulate the mouse immune system. (Source: The Scientist)


Monday 10 August 2015

ESA Issues Statement on Tick-borne Diseases

Annapolis, MD; August 10, 2015 – The Entomological Society of America (ESA) recently released a statement (http://www.entsoc.org/ticks) supporting the creation and implementation of a national strategy using Integrated Tick Management to better control tick populations and reduce the rapidly escalating impact of tick-borne diseases such as Rocky Mountain spotted fever, tularemia, and Lyme disease. read more (Source: ESA News)

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Monday 10 August 2015

Woman Loses Vision After Mosquito Bite Transmits Chikungunya Fever

By: Laura Geggel Published: 08/10/2015 10:38 AM EDT on LiveScience A woman who caught chikungunya fever while vacationing in the Caribbean wound up losing some of the vision in her right eye permanently, according to a new report of her case. The findings suggest that vision problems may be an underreported effect of the mosquito-transmitted virus, which has spread in recent years from Africa and Asia to the Caribbean, Latin America and parts of the United States, the report's authors said. "Sight-threatening visual loss can be a late complication of infection with chikungunya," said Dr. Abhijit Mohite, who treated the woman and co-authored the report of her case. [7 Devastating Infectious Diseases] It is important that people with vision problems get treatment early, to prevent lasting vi...


Monday 10 August 2015

Entomological Society of America issues statement on tick-borne diseases

(Entomological Society of America) The Entomological Society of America (ESA) recently released a statement supporting the creation and implementation of a national strategy using Integrated Tick Management to better control tick populations and reduce the rapidly escalating impact of tick-borne diseases such as Rocky Mountain spotted fever, tularemia, and Lyme disease. (Source: EurekAlert! - Medicine and Health)


Monday 10 August 2015

The lipid raft proteome of Borrelia burgdorferi

This study provides the first analysis of a prokaryotic lipid raft and has relevance for the biology of Borrelia, other pathogenic bacteria, as well as for the evolution of these structures. This article is protected by copyright. All rights reserved (Source: Proteomics)


Sunday 9 August 2015

Molecular identification and bioinformatics analysis of a potential anti-vector vaccine candidate, 15-kDa salivary gland protein (Salp15), from Ixodes affinis ticks

In this study, we have identified a Salp15 homolog, designated as Iaff15, from Ixodes affinis ticks that are the principal enzootic vectors of B. burgdorferi sensu stricto in the southeastern part of the United States. Comparison of the annotated amino acid sequences showed that Iaff15 share 81% homology with I. sinensis Salp15 homolog and 64% homology with I. scapularis Salp15. Phylogenetic analysis revealed that Iaff15 come within the same clade with I. sinensis, I. scapularis and I. pacificus Salp15 homologs. The bioinformatics analysis of the posttranslational modifications prediction revealed that all the Salp15 family members contain glycosylation sites. In addition, Iaff15 carried a higher number of Casein Kinase II phosphorylation sites in comparison to the other Salp15 family memb...


Saturday 8 August 2015

10 Essential Facts About Lyme Disease

By Allison Pohle for Everyday Health Every year, U.S. state health departments report about 30,000 cases of Lyme disease to the Centers for Disease Control and Prevention (CDC). But the CDC says the true number of cases in the United States could be ten times as high. Lyme disease is transmitted to humans from tick bites. The ticks that transmit the disease are most active from April to September, which means spring and summer are the prime times for infection. With the right steps, and regular tick checks, however, you can prevent Lyme disease. Here are 10 things you should know about this tickborne disease: 1. You can only get Lyme disease from a tick bite. There is no evidence that Lyme disease can be transmitted from person-to-person, according to the CDC. You also can’t get Lyme dis...


Saturday 8 August 2015

Mayo Clinic Q and A: Take precautions to avoid ticks and Lyme disease

DEAR MAYO CLINIC: In the summer, my kids play outdoors most of the day, and we have found ticks on their clothing. Is Lyme disease something I should be worried about? What are the early symptoms? Does bug spray keep ticks away? ANSWER: Lyme disease is the most common illness spread by ticks in the [...] (Source: News from Mayo Clinic)

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Saturday 8 August 2015

Detection, identification and genotyping of Borrellia spp. in rodents in Slovenia by PCR and culture

Conclusion: We determined the prevalence of B. afzelii in rodents and report for the first time the presence of B. miyamotoi in Slovenia. (Source: BMC Veterinary Research)


Saturday 8 August 2015

Pathogenesis and the Immune Response

Borrelia burgdorferi is the tick-borne etiologic agent of Lyme disease. The spirochete must negotiate numerous barriers in order to establish a disseminated infection in a mammalian host. These barriers include migration from the feeding tick midgut to the salivary glands, deposition in skin, manipulation or evasion of the localized host immune response, adhesion to and extravasation through an endothelial barrier, hematogenous dissemination, and establishment of infection in distal tissue sites. Borrelia burgdorferi proteins that mediate many of these processes and the nature of the host response to infection are described. (Source: Clinics in Laboratory Medicine)


Thursday 6 August 2015

Relatively low prevalence of Babesia microti and Anaplasma phagocytophilum in Ixodes scapularis ticks collected in the Lehigh Valley region of eastern Pennsylvania

Publication date: Available online 5 August 2015 Source:Ticks and Tick-borne Diseases Author(s): Marten J. Edwards, Laura A. Barbalato, Amulya Makkapati, Katerina D. Pham, Louise M. Bugbee Several human pathogens are transmitted by the blacklegged tick, Ixodes scapularis. These include the spirochetes that cause Lyme disease (Borrelia burgdorferi) which is endemic to the Lehigh Valley region of eastern Pennsylvania. Emerging and currently rare tick-borne diseases have been of increasing concern in this region, including tick-borne relapsing fever (caused by Borrelia miyamotoi), human granulocytic anaplasmosis (caused by Anaplasma phagocytophilum), and human babesiosis (caused by Babesia microti). Real-time PCR assays and in some instances, conventional PCR followed by DNA sequencing...

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Thursday 6 August 2015

Middle region of the Borrelia burgdorferi surface‐located protein 1 (Lmp1) interacts with host chondroitin‐6‐sulfate and independently facilitates infection

This article is protected by copyright. All rights reserved. (Source: Cellular Microbiology)


Thursday 6 August 2015

Undiagnosed Lyme disease in adults with schizophrenia

Lyme disease (LD) is the world's leading tick borne infection caused by the spirochete, Borrelia burgdorferi (Bb). This infection is a global health concern and is associated with numerous cardiologic, dermatologic, rheumatologic neurologic, and psychiatric manifestations (Bratton et al., 2008). Only a few epidemiologic studies have evaluated the frequency of antibodies to Bb in psychiatric patients; one study found only 1/517 (0.2%) of all adult psychiatric patients had Lyme titer seropositivity (Nadelman et al., 1997) and the other larger study found that 322/926 (35%) of psychiatric inpatients had seropositivity to antibodies to Bb (Hajek et al., 2002). (Source: Schizophrenia Research)


Wednesday 5 August 2015

Managing monoarthritis in children

Publication date: Available online 4 August 2015 Source:Joint Bone Spine Author(s): Valérie Devauchelle-Pensec, Matthias Thepaut, Romain Pecquery, Laetitia Houx Monoarthritis, defined as inflammation of a single joint, requires a thorough physical examination in children, as pain may be lacking in 10% to 30% of cases and joint stiffness may be the only symptom. Joint aspiration is a crucial diagnostic tool that remains markedly underused. Joint aspiration may be unnecessary, however, when the family history or other investigations provide the diagnosis. Radiographs of the involved joint may supply information on the severity of the lesions. In doubtful cases and in patients with arthralgia, B-mode and Doppler ultrasound or magnetic resonance imaging (MRI) may confirm the presence of...


Wednesday 5 August 2015

[Lyme disease in paediatrics].

Authors: Vázquez-López ME, Pérez-Pacín R, Díez-Morrondo C, Díaz P, Castro-Gago M PMID: 26254967 [PubMed - as supplied by publisher] (Source: Anales de Pediatria)


Monday 3 August 2015

A Therapy That Rebuilds Your Defenses FAST

In ancient times, our ancestors had pure sources of the nutrients they needed to thrive. But they were limited in terms of how much they could get of any particular one. Organ meat gives you a wealth of nutrients, including protein, CoQ10, and a host of vitamins. But you can’t get really high doses of a nutrient or vitamin through food alone. That wasn’t a big issue for our ancestors because they had such a well-balanced environment. But it’s a big deal for you and me. In our toxic world, large doses of nutrients are sometimes necessary to balance or “straighten out” health concerns. This is a category of medicine I call “Ortho.” Ortho means, “to correct or straighten out.” If your basic needs for survival happen on a “Primal̶...


Monday 3 August 2015

Borrelia yangtzensis sp. nov. a rodent associated species in Asia is related to B. valaisiana.

Authors: Margos G, Chu CY, Takano A, Jiang BG, Liu W, Kurtenbach K, Masuzawa T, Fingerle V, Cao WC, Kawabata H Abstract Twenty nine isolates of Lyme borreliosis (LB) group spirochetes collected from ticks and rodents in China and Japan were included into multilocus sequence analysis (MLSA). Using a different typing system, three of these strains had previously been identified as being divergent from other LB spirochete species and the name "Borrelia yangtze" sp. nov. was proposed. The data presented here confirm that the genetic distance calculated using sequences of MLSA housekeeping genes to other known LB group spirochete species was <95 % and to B. valaisiana 96.67 % (which represents the closest related species within the group of LB spirochetes). This and the fact that the...

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Saturday 1 August 2015

Pathogenesis of Lyme Neuroborreliosis in an Animal Model of Infection.

Authors: Baker PJ Abstract This Correspondence relates to the article by Ramesh et al (Inflammation in the pathogenesis of Lyme neuroborreliosis. Am J Pathol, 2015, 185:1344-1360). PMID: 26216287 [PubMed - in process] (Source: The American Journal of Pathology)


Saturday 1 August 2015

Treatment of Lyme neuroborreliosis with plasmapheresis

This study highlights that plasmapheresis could be a useful alternative for pediatric neuroborreliosis cases. J. Clin. Apheresis, 2015. © 2015 Wiley Periodicals, Inc. (Source: Journal of Clinical Apheresis)


Saturday 1 August 2015

The Many Masks of Cutaneous Lyme Disease

Abstract Early cutaneous Lyme disease, erythema migrans, may show different histopathologic patterns. The intent of this case series is to raise awareness of these findings to prevent misdiagnosis and keep this entity in the differential. Erythema migrans develops after a tick bite and subsequent infection with the spirochete, Borrelia burgdorferi. It most commonly manifests as a solitary, annular lesion with a bull's‐eye appearance. Classic histopathologic findings include superficial and deep perivascular and interstitial lymphocytic infiltrates mixed with plasma cells and eosinophils. We identified and reviewed 8 cases of early erythema migrans. Each patient had confirmed B. burgdorferi IgM seropositivity and IgG seronegativity. Histopathologic evaluation of these biopsies reveals a d...


Thursday 30 July 2015

Stoke University Hospital patient wakes from hysterectomy operation to find teeth missing

Clare Jones, 47, from Newcastle-under-Lyme, woke to two teeth missing after her operation at the Royal Stoke University Hospital. An investigation has been launched to establish what happened. (Source: the Mail online | Health)


Wednesday 29 July 2015

Molecular survey of tick-borne pathogens in Ixodid ticks collected from hunted wild animals in Tuscany, Italy

Conclusions The results demonstrate the presence of several zoonotic tick-borne pathogens in the studied area, and underline the risk of exposure to infections for hunters not only during the outdoor activity, but also when they manipulate hunted animals infested by infected ticks. (Source: Asian Pacific Journal of Tropical Medicine)


Wednesday 29 July 2015

Learn the ABCs of Ticks with Dr. Bobbi Pritt

https://www.youtube.com/watch?v=TX-fDlBRQns More areas in the United States are seeing human cases of Lyme disease. A recent report by the Centers for Disease Control and Prevention (CDC) shows a significant increase in geographic areas — as much as 320 percent in the Northeast — determined as high risk for contracting the tick-borne illness. The Mayo Clinic Department of Laboratory Medicine and [...] (Source: News from Mayo Clinic)


Tuesday 28 July 2015

Improving national surveillance of Lyme neuroborreliosis in Denmark through electronic reporting of specific antibody index testing from 2010 to 2012.

Authors: Dessau RB, Espenhain L, Molbak K, Krause TG, Voldstedlund M PMID: 26212143 [PubMed - in process] (Source: Euro Surveill)

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Tuesday 28 July 2015

Pediatric Acute Longitudinal Extensive Transverse Myelitis Secondary to Neuroborreliosis

We present the case of a 16-year-old male who developed acute left peripheral facial palsy and longitudinal extensive TM secondary to Lyme disease. Remarkably, the patient reported only mild symptoms with severe back pain in the absence of profound signs of myelopathy. We reviewed the medical literature and analyzed the clinical features of pediatric patients with Borrelia burgdorferi-related TM.Case Rep Neurol 2015;7:162-166 (Source: Case Reports in Neurology)


Tuesday 28 July 2015

Lyme neuroborreliosis—epidemiology, diagnosis and management

Nature Reviews Neurology 11, 446 (2015). doi:10.1038/nrneurol.2015.121 Authors: Uwe Koedel, Volker Fingerle & Hans-Walter Pfister Lyme disease, caused by the Borrelia burgdorferi bacterium, is the most common vector-borne disease in the northern hemisphere. The clinical presentation varies with disease stage, and neurological manifestations (often referred to as Lyme neuroborreliosis) are reported in up to 12% of patients with Lyme (Source: Nature Reviews Neurology)


Tuesday 28 July 2015

Serological signature of tick-borne pathogens in Scandinavian brown bears over two decades

Conclusions: Our study is consistent with the view that ticks and tick-borne pathogens are expanding their abundance and prevalence in Scandinavia. Long-term serological monitoring of large mammals can provide insight into how anthropogenic disturbances are changing the distribution of ticks and tick-borne diseases. (Source: Parasites and Vectors)


Monday 27 July 2015

Here's What You Need To Know About Ticks

Bad news: Lyme disease, the most common tick-borne illness, has more than doubled over the past 20 years. In 1995 there were just over 10,000 cases of Lyme disease reported. By 2013 there were over 25,000 confirmed cases and over 35,000 possible cases, according to the Centers for Disease Control and Prevention.  While Lyme disease is curable with antibiotics when caught in early stages, if untreated, the illness can cause permanent and potentially devastating complications, from memory loss to chronic joint inflammation to heart arrhythmia. Know Your Risk While Lyme disease is the most famous illness ticks carry, it's far from the only one. Others include babesiosis, a disease caused by microscopic parasites that infect red blood cells, ehrlichiosis, a general name for...


Monday 27 July 2015

The Neuroscience Report—Vol. 13 (July 27, 2015): Medical Illness or Mental Disorder?

The latest in neuroscience—sorted and summarized for you Welcome to the Neuroscience Report where each week we will highlight a specific topic in neuroscience and provide you with links to 5 journal articles, 5 news articles, and 5 wildcard picks. Brought to you by Innovations in Clinical Neuroscience—your source for peer-reviewed, evidence-based information. Volume 13 (July 27, 2015): Medical Illness or Mental Disorder? Journal Articles Hoarseness: A Sign of Self-induced Vomiting? Thiamine Deficiency and Delirium Workplace Bullying: A Tale of Adverse Consequences Conversion Disorder— Mind Versus Body: A Review Differential Diagnosis of Hallucinations in a Patient with Myasthenia Gravis   News Articles Childhood Trauma Can Lead to Adult Migraines Novel Drug Mechanism Addr...


Saturday 25 July 2015

Pathogenesis of Lyme Neuroborreliosis in an Animal Model of Infection

This Correspondence relates to the article by Ramesh et al (Inflammation in the pathogenesis of Lyme neuroborreliosis. Am J Pathol, 2015, 185:1344–1360). (Source: American Journal of Pathology)

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Saturday 25 July 2015

Comparison of effectiveness of cefovecin, doxycycline, and amoxicillin for the treatment of experimentally induced early Lyme borreliosis in dogs

Conclusions: Convenia was efficacious against B. burgdorferi sensu stricto infection in dogs as determined by serological testing, PCR and histopathology results. Convenia provides an additional and effective treatment option for Lyme Disease in dogs. (Source: BMC Veterinary Research)


Friday 24 July 2015

Geographic Distribution and Expansion of Human Lyme Disease, United States.

We present a method for defining high-risk counties based on observed versus expected number of reported human Lyme disease cases. Applying this method to successive periods shows substantial geographic expansion of counties at high risk for Lyme disease. PMID: 26196670 [PubMed - as supplied by publisher] (Source: Emerging Infectious Diseases)


Friday 24 July 2015

Identification of the minimal cytolytic unit for streptolysin S and an expansion of the toxin family

Conclusions: The mutagenesis data described herein indicate that the minimal cytolytic unit of SLS encompasses the NPH region of the core peptide. Interestingly, this region is found in all characterized TOMM cytolysins, as well as the novel putative TOMM cytolysins we discovered. We propose that this conserved region represents the defining feature of the SLS-like TOMM family. We demonstrate the cytolytic potential of a Bbsl SLS-like precursor peptide, which has a core region of similar length to the SLS minimal cytolytic unit, when modified with purified SLS biosynthetic enzymes. As such, we speculate that some Borrelia have the potential to produce a TOMM cytolysin, although the biological significance of this finding remains to be determined. In addition to providing new insight into t...


Wednesday 22 July 2015

Application of multiplexing technology to the analysis of the intrathecally released immunoglobulins against B. burgdorferi antigens in neuroborreliosis.

Authors: Zajkowska J, Lelental N, Kulakowska A, Mroczko B, Pancewicz S, Bucki R, Kornhuber J, Lewczuk P Abstract Lyme neuroborreliosis (LNB) is an infectious disease of the nervous system caused by the tick-borne spirochete Borrelia burgdorferi. The presence of Borrelia burgdorferi specific antibodies in cerebrospinal fluid (CSF), with evidence of intrathecal production, is the traditional diagnostic standard, although has limitations it such as low sensitivity in the very early phase. In the current study, 27 patients with possible neuroborreliosis suffered from clinically defined Bannwarth syndrome. The control group (CON) consisted of 6 patients. The analyses included function of the blood-CSF barrier (QAlb) as well as intrathecal synthesis of total IgG and IgM, (QIgG, and QIgM)...

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Wednesday 22 July 2015

Lyme Disease: Why It's Spreading, How It Makes You Sick, and What To Do About It Barbour Alan G Lyme Disease: Why It's Spreading, How It Makes You Sick, and What To Do About It 330pp £15 Johns Hopkins University Press 978-1421417219 1421417219 [Formula: see text].

Authors: Abstract Lyme disease expert Alan Barbour has been involved in research into the disease since the 1982 discovery of borrelia burgdorferi, the causative agent of the disease. PMID: 26198512 [PubMed - in process] (Source: Nursing Standard)


Tuesday 21 July 2015

Lyme disease threat in the U.S. has spiked 320 percent

The CDC says the high-risk area for lyme disease is spreading (Source: Health News: CBSNews.com)


Monday 20 July 2015

TGen and NAU developing accurate test to diagnose debilitating Lyme disease

(The Translational Genomics Research Institute) Focus On Lyme, an initiative sponsored by the Leadership Children's Foundation of Gilbert, Ariz., has donated $75,000 to the Translational Genomics Research Institute to support research into the development of a quick, affordable and accurate method of diagnosing Lyme disease. The most common vector-borne illness in the US, Lyme disease affects an estimated 300,000 Americans annually. (Source: EurekAlert! - Medicine and Health)


Monday 20 July 2015

Critical review of studies trying to evaluate the treatment of chronic Lyme disease.

Authors: Perronne C PMID: 26206701 [PubMed - as supplied by publisher] (Source: Presse Medicale)


Monday 20 July 2015

[Lyme disease: Where is the controversy?]

Authors: Hansmann Y, Cazenave-Roblot F, Weinbreck P, Michelet C, Caumes E PMID: 26206702 [PubMed - as supplied by publisher] (Source: Presse Medicale)


Friday 17 July 2015

The results are in: Inhalable Ebola vaccine, spread of Lyme disease

(Source: CNN.com - Health)


Friday 17 July 2015

Lyme Disease Cases Rising in Affected RegionsLyme Disease Cases Rising in Affected Regions

In a 20-year period, the number of high-incidence counties more than tripled in the northeastern states and more than doubled in north-central states. Medscape Medical News (Source: Medscape Emergency Medicine Headlines)


Friday 17 July 2015

Laboratory Diagnosis of Lyme Disease

Publication date: June 2015 Source:Infectious Disease Clinics of North America, Volume 29, Issue 2 Author(s): Adriana R. MarquesTeaser The majority of laboratory tests performed for the diagnosis of Lyme disease are based on detection of the antibody responses against B burgdorferi in serum. The sensitivity of antibody-based tests increases with the duration of the infection. Patients early in their illness are more likely to have a negative result. There is a need to simplify the testing algorithm for Lyme disease, improving sensitivity in early disease while still maintaining high specificity and providing information about the stage of infection. The development of a point of care assay and biomarkers for active infection would be major advances for the field. (Source: Infectious Dis...


Friday 17 July 2015

Erratum to: Physician reported incidence of early and late Lyme borreliosis

No description available (Source: Parasites and Vectors)


Thursday 16 July 2015

U.S. High-Risk Areas for Lyme Disease Increasing

(Source: WebMD Health)

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Thursday 16 July 2015

High-risk areas for Lyme disease growing, CDC says

Twice as many counties now have high Lyme disease risk, compared to a decade ago (Source: Health News: CBSNews.com)


Thursday 16 July 2015

Stroke-like Phenomena Revealing Multifocal Cerebral Vasculitis in Pediatric Lyme Neuroborreliosis

We report a previously healthy 12-year-old boy who presented with acute left hemiparesis and meningeal signs. Neuroimaging failed to reveal any cerebral infarction but demonstrated a multifocal cerebral vasculitis involving small, medium and large-sized vessels affecting both the anterior and posterior circulation. Concentric contrast enhancement of the basilar artery was also observed. Further investigations and laboratory findings were consistent with Lyme neuroborreliosis. A rapidly favorable clinical outcome was obtained with appropriate antibiotic treatment along with antiaggregants and steroids. Lyme neuroborreliosis should be considered in the diagnostic differential, not only in adults but also among children, especially in the context of an unexplained cerebral vasculitis. (Source...


Thursday 16 July 2015

A Dutch nationwide evaluation of serological assays for detection of antibodies in clinically well-defined patients

Numerous tests for the detection of antibodies against Borrelia burgdorferi are commercially available. Manufacturer derived data invariably report a high sensitivity and specificity but comparative studies demonstrate large differences in clinical practice, especially with regard to specificity. We retrospectively collected data from validation studies for Borrelia burgdorferi antibody assays from eight laboratories in the Netherlands. The total number of samples was 809. Samples were selected based on clinical and laboratory parameters. (Source: Diagnostic Microbiology and Infectious Disease)

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Thursday 16 July 2015

Uveitis in adults: What do rheumatologists need to know?

Publication date: Available online 14 July 2015 Source:Joint Bone Spine Author(s): Pascal Sève, Laurent Kodjikian, Léopold Adélaïde, Yvan Jamilloux Rheumatologists may need to establish the etiological diagnosis and handle the therapeutic management of adults with uveitis. To date, no diagnostic strategy for uveitis has been validated by prospective studies. Investigations are selected based on the clinical features and on the anatomic location of the ocular abnormalities. Infections such as syphilis, Lyme disease, tuberculosis, and Whipple's disease may cause uveitis, with concomitant joint inflammation in a few cases. In patients with a known history of chronic inflammatory joint disease, causes of uveitis include bisphosphonate therapy and immunodepression-related infections (...


Thursday 16 July 2015

Lyme Disease Manifestations in the Foot and Ankle: A Retrospective Case Series

Lyme disease is the result of Borrelia burgdorferi bacterial infection after exposure from a tick bite. A pathognomonic finding in early-stage Lyme disease is an expanding, red macular ring known as erythema migrans. Lyme arthritis is a late-stage manifestation of this disease, affecting the large, weightbearing joints with intermittent pain and swelling. The existing data on Lyme disease and subsequent arthritis have reported manifestations in the lower extremity, primarily in the knee and ankle and less commonly the small joints of the foot. (Source: Journal of Foot and Ankle Surgery)


Thursday 16 July 2015

Lyme Disease Manifestations in the Foot and Ankle: A Retrospective Case Series

We present a retrospective case series of 11 cases of painful arthritis in the foot and ankle with confirmatory Lyme disease testing. (Source: The Journal of Foot and Ankle Surgery)


Thursday 16 July 2015

Improving national surveillance of Lyme neuroborreliosis in Denmark through electronic reporting of specific antibody index testing from 2010 to 2012

(Source: Eurosurveillance)

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Wednesday 15 July 2015

Lyme Disease Manifestations in the Foot and Ankle: A Retrospective Case Series

Lyme disease is the result of Borrelia burgdorferi bacterial infection after exposure from a tick bite. A pathognomonic finding in early-stage Lyme disease is an expanding, red macular ring known as erythema migrans. Lyme arthritis is a late-stage manifestation of this disease, affecting the large, weightbearing joints with intermittent pain and swelling. The existing data on Lyme disease and subsequent arthritis have reported manifestations in the lower extremity, primarily in the knee and ankle and less commonly the small joints of the foot. (Source: Journal of Foot and Ankle Surgery)


Wednesday 15 July 2015

Course and Outcome of Early Lyme Borreliosis in Patients With Hematological Malignancies

Patients with erythema migrans and underlying hematological malignancy more often had signs of disseminated Lyme borreliosis and more frequently needed antibiotic retreatment than sex-, age-, and antibiotic treatment–matched immunocompetent persons with erythema migrans. However, the outcome was excellent in both groups. (Source: Clinical Infectious Diseases)


Tuesday 14 July 2015

A novel duplex real-time PCR permits simultaneous detection and differentiation of Borrelia miyamotoi and Borrelia burgdorferi sensu lato

Conclusion The duplex real-time PCR developed here represents a method that permits simultaneous detection and differentiation of B. burgdorferi s.l. and B. miyamotoi in environmental and potentially clinical samples. (Source: Infection)


Tuesday 14 July 2015

Annexin A2 Is a Target of Autoimmune T and B Cell Responses Associated with Synovial Fibroblast Proliferation in Patients with Antibiotic-Refractory Lyme Arthritis.

In this study, autoantibody responses to annexin A2 were found in 11-15% of 278 patients with Lyme disease, including in those with erythema migrans (EM), an early sign of the illness, and in those with antibiotic-responsive or antibiotic-refractory Lyme arthritis (LA), a late disease manifestation. In contrast, robust T cell reactivity to annexin A2 peptides was found only in patients with responsive or refractory LA. In LA patients, annexin A2 protein levels, which were higher in the refractory group, correlated with annexin A2 antibody levels in sera and synovial fluid. In addition, in patients with antibiotic-refractory LA who had anti-annexin A2 antibodies, synovial tissue had intense staining for annexin A2 protein, greater synovial fibroblast proliferation and more tissue fibrosis. ...


Saturday 11 July 2015

An Examination of the Demographic and Environmental Variables Correlated with Lyme Disease Emergence in Virginia

This study used a Geographic Information System and a spatial Poisson regression model to examine correlations between demographic and land cover variables, and human Lyme disease from 2006 to 2010 in Virginia. Analysis indicated that herbaceous land cover is positively correlated with Lyme disease incidence rates. Areas with greater interspersion between herbaceous and forested land were also positively correlated with incidence rates. In addition, income and age were positively correlated with incidence rates. Levels of development, interspersion of herbaceous and developed land, and population density were negatively correlated with incidence rates. Abundance of forest fragments less than 2 hectares in area was not significantly correlated. Our results support some findings of previous ...

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Friday 10 July 2015

Low risk of seroconversion or clinical disease in humans after a bite by an Anaplasma phagocytophilum-infected tick

In this study we investigated the clinical and serological response in 30 humans bitten by ticks positive for Anaplasma phagocytophilum (Group A), 30 humans bitten by Borrelia burgdorferi sensu lato (s.l.)-positive ticks (Group B), and 30 humans bitten by ticks negative for both A. phagocytophilum and B. burgdorferi s.l. (Group C). Ticks, blood samples and questionnaires were collected from tick-bitten humans at 34 primary healthcare centres in Sweden and in the Åland Islands, Finland, at the time of the tick bite and after three months. A total of 2 553 ticks detached from humans in 2007-2009 were analysed by polymerase chain reaction, and 31 (1.2%) were positive for A. phagocytophilum, 556 (21.8%) were positive for B. burgdorferi s.l., and eight (0.3%) were co-infected by A. phagocytop...


Wednesday 8 July 2015

Mass. Residents Warned To Protect Against Ticks, Lyme Disease

BOSTON (CBS) — The State Department of Public Health is advising the public on how to avoid Lyme disease at a time when it’s been declared an epidemic in parts of the state. Deer ticks are thriving in the warm weather, especially south of Boston, where the growing deer population has brought an increased risk of ticks that spread Lyme disease. That’s why the Department of Public Health is posting videos reminding people to use insect repellent and check for ticks. “Just like you put on sunscreen, make it a habit to use an EPA-approved repellent anytime you are outdoors,” the video says. Early signs of Lyme disease are a rash followed by fever, chills and body aches, which can escalate to severe joint pain and neurological damage. WBZ NewsRadio 1030’s Carl Stevens ...


Wednesday 8 July 2015

A Short-Term Borrelia burgdorferi Infection Model Identifies Tissue Tropisms and Bloodstream Survival Conferred by Adhesion Proteins [Molecular Pathogenesis]

Borrelia burgdorferi, the causative agent of Lyme disease in the United States, is able to persist in the joint, heart, skin, and central nervous system for the lifetime of its mammalian host. Borrelia species achieve dissemination to distal sites in part by entry into and travel within the bloodstream. Much work has been performed in vitro describing the roles of many B. burgdorferi outer surface proteins in adhesion to host cell surface proteins and extracellular matrix components, although the biological relevance of these interactions is only beginning to be explored in vivo. A need exists in the field for an in vivo model to define the biological roles of B. burgdorferi adhesins in tissue-specific vascular interactions. We have developed an in vivo model of vascular interaction of B. ...


Wednesday 8 July 2015

Interferon-α curbs production of interleukin-22 by human peripheral blood mononuclear cells exposed to live Borrelia burgdorferi.

Authors: Berner A, Bachmann M, Pfeilschifter J, Kraiczy P, Mühl H Abstract Cytokine networks initiated by means of innate immunity are regarded as a major determinant of host defence in response to acute infection by bacteria including Borrelia burgdorferi. Herein, we demonstrate that interferon (IFN)-α, either endogenously produced after exposure of cells to toll-like receptor-9-activating CpG oligonucleotides or provided as recombinant cytokine, weakens activation of the anti-bacterial interleukin (IL)-1/IL-22 axis in human peripheral blood mononuclear cells exposed to viable B. burgdorferi. As IFN-α has been related to pathological dissemination of the spirochaete, data suggest an immunoregulatory role of type I IFN in this context that is able to significantly modify cytoki...

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Wednesday 8 July 2015

Interferon‐α curbs production of interleukin‐22 by human peripheral blood mononuclear cells exposed to live Borrelia burgdorferi

Abstract Cytokine networks initiated by means of innate immunity are regarded as a major determinant of host defence in response to acute infection by bacteria including Borrelia burgdorferi. Herein, we demonstrate that interferon (IFN)‐α, either endogenously produced after exposure of cells to toll‐like receptor‐9‐activating CpG oligonucleotides or provided as recombinant cytokine, weakens activation of the anti‐bacterial interleukin (IL)‐1/IL‐22 axis in human peripheral blood mononuclear cells exposed to viable B. burgdorferi. As IFN‐α has been related to pathological dissemination of the spirochaete, data suggest an immunoregulatory role of type I IFN in this context that is able to significantly modify cytokine profiles thereby possibly determining early course of B....


Wednesday 8 July 2015

Cyclic di-GMP Modulates Gene Expression in Lyme Disease Spirochetes at the Tick-Mammal Interface To Promote Spirochete Survival during the Blood Meal and Tick-to-Mammal Transmission [Molecular Pathogenesis]

Borrelia burgdorferi, the Lyme disease spirochete, couples environmental sensing and gene regulation primarily via the Hk1/Rrp1 two-component system (TCS) and Rrp2/RpoN/RpoS pathways. Beginning with acquisition, we reevaluated the contribution of these pathways to spirochete survival and gene regulation throughout the enzootic cycle. Live imaging of B. burgdorferi caught in the act of being acquired revealed that the absence of RpoS and the consequent derepression of tick-phase genes impart a Stay signal required for midgut colonization. In addition to the behavioral changes brought on by the RpoS-off state, acquisition requires activation of cyclic di-GMP (c-di-GMP) synthesis by the Hk1/Rrp1 TCS; B. burgdorferi lacking either component is destroyed during the blood meal. Prior studies att...


Tuesday 7 July 2015

The Mystery of Chronic Lyme Disease

After being treated for Lyme disease, some patients continue to have severe symptoms of the tick-borne disease for years. Experts are divided on what causes this and how to treat it. (Source: WSJ.com: Health)



Monday 6 July 2015

How ticks that carry Lyme disease are spreading to new regions in the US

(Wiley) Lyme disease is currently estimated to affect 300,000 people in the US every year, and blacklegged ticks, the disease's main vector, have recently flourished in areas previously thought to be devoid of this arachnid. (Source: EurekAlert! - Infectious and Emerging Diseases)

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Monday 6 July 2015

A man with cardiac Lyme borreliosis.

Authors: van Hattem JM, Keijer JT, Nijveldt R PMID: 26149700 [PubMed - as supplied by publisher] (Source: cmaj)


Monday 6 July 2015

Borrelia burgdorferi sensu lato-infected Ixodes ricinus collected from vegetation near the Arctic Circle

Publication date: Available online 6 July 2015 Source:Ticks and Tick-borne Diseases Author(s): Dag Hvidsten , Frode Stordal , Malin Lager , Bjørg Rognerud , Bjørn-Erik Kristiansen , Andreas Matussek , Jeremy Gray , Snorre Stuen This is the first study to determine the density of questing Ixodes ricinus in northern Norway. It was performed at two sites in Brønnøy, which has been known for its tick permissive habitats for decades and is one of the northernmost habitats with an abundant I. ricinus population in the world. From April to November 2011, all stages of host-seeking I. ricinus were collected from the two sites. The overall prevalence of nymphs infected with Borrelia burgdorferi sensu lato was 21% and that of adult ticks 46%. The rates of the genospecies B. afzelii, B. garinii...


Saturday 4 July 2015

Intestinal Pseudoobstruction Caused by Chronic Lyme Neuroborreliosis. A Case Report.

Authors: Schefte DF, Nordentoft T Abstract Chronic intestinal pseudoobstruction is often classified as idiopathic. The condition is associated with poor quality of life and high morbidity, and treatment options are often unsatisfactory. A case of chronic intestinal pseudoobstruction in a 66-year-old woman, presenting with back and abdominal pain, urinary retention and severe constipation is described. The patient lived in an area in which Lyme disease is endemic and had been bitten by ixodes ticks. Intrathecal synthesis of anti-borrelia IgM and IgG and lymphocytosis in the cerebrospinal fluid was found, consistent with chronic Lyme neuroborreliosis since symptoms had lasted for more than six months. The patient's gastrointestinal function recovered and the pain subsided significant...


Friday 3 July 2015

First report of Lyme neuroborreliosis in a returned Australian traveller.

Authors: Subedi S, Dickeson DJ, Branley JM PMID: 26126566 [PubMed - in process] (Source: Med J Aust)

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Friday 3 July 2015

Another Tick Threat?

I understand that there's a new danger from tick bites that is worse than Lyme disease, and that a virus transmitted by these bites can actually kill you. Can you tell me where these ticks are and how to avoid them? (Source: Dr. Weil Q and A)


Friday 3 July 2015

Epidemiological situation of Lyme borreliosis in Belgium, 2003 to 2012

Conclusion Based on hospital records and laboratory results, no increasing trend in Lyme disease was observed over the 2003–2012 period in Belgium. These results are in line with the stable incidence of erythema migrans reported by a sentinel network of general practitionners between 2003 and 2009. Multi-source surveillance of vector-borne diseases should be further implemented. (Source: Archives of Public Health)


Friday 3 July 2015

Lyme Disease: What the Wilderness Provider Needs to Know

Publication date: Available online 2 July 2015 Source:Wilderness & Environmental Medicine Author(s): Joseph D. Forrester , J. Priyanka Vakkalanka , Christopher P. Holstege , Paul S. Mead Lyme disease is a multisystem tickborne illness caused by the spirochete Borrelia burgdorferi and is the most common vectorborne disease in the United States. Prognosis after initiation of appropriate antibiotic therapy is typically good if treated early. Wilderness providers caring for patients who live in or travel to high-incidence Lyme disease areas should be aware of the basic biology, epidemiology, clinical manifestations, and treatment of Lyme disease. (Source: Wilderness and Environmental Medicine)


Wednesday 1 July 2015

Enhancing Lyme Disease Surveillance by Using Administrative Claims Data, Tennessee, USA

J. L. Clayton et al. (Source: Emerging Infectious Diseases Journal)


Wednesday 1 July 2015

The increasing risk of Lyme disease in Canada.

The objectives of this article are to i) raise public awareness with the help of veterinarians on the emerging and expanding risk of Lyme disease across Canada, ii) review the key clinical features of Lyme disease in dogs, and iii) provide recommendations for veterinarians on the management of Lyme disease in dogs. PMID: 26130829 [PubMed - in process] (Source: The Canadian Veterinary Journal)


Tuesday 30 June 2015

Morning Break: Ebola Back in Liberia, SCOTUS Redux, Lavigne's Lyme Lament

(MedPage Today) -- Health news and commentary from around the Web, gathered by the MedPage Today staff. (Source: MedPage Today Public Health)


Tuesday 30 June 2015

Avril Lavigne 'doing a lot better' after Lyme disease treatment

(Source: CNN.com - Health)


Tuesday 30 June 2015

Tiny ticks could wreck your health for years says Lyme Disease Action

According to the NHS, in Britain around 3,000 people a year are diagnosed with Lyme disease. Six years ago, James, then aged ten, developed the condition. (Source: the Mail online | Health)


Tuesday 30 June 2015

Patterns of tick infestation and their Borrelia burgdorferi s.l. infection in wild birds in Portugal

This study contributed to a better knowledge of the Ixodidae tick fauna parasitizing birds in Western Europe and to the assessment of the prevalence of B. burgdorferi s.l. associated with birds and their ticks. (Source: Ticks and Tick borne Diseases)

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Monday 29 June 2015

'I thought I was dying,' Avril Lavigne says of Lyme disease fight

When singer Avril Lavigne went missing from the music scene, there was tons of speculation. Was she pregnant? In rehab? Going through a split from her husband, Nickelback front man Chad Kroeger? (Source: CNN.com - Health)

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Monday 29 June 2015

Avril Lavigne Breaks Down During Interview About Lyme Disease

Avril Lavigne made an emotional appearance on "Good Morning America" on Monday, as she opened up about her battle with Lyme disease. The 30-year-old singer broke down in tears as she revealed she was bedridden by the disease last October and frustrated as she saw specialist after specialist, each unable to properly diagnose her Lyme disease. "They would pull up their computer and be like, 'Chronic fatigue syndrome.' Or, 'Why don't you try to get out of bed, Avril, and just go play the piano?' It's like, 'Are you depressed?'" she explained to "GMA" special contributor Jesse Palmer. The singer added, "This is what they do to a lot of people who have Lyme disease. They don't have an answer for them so they tell them, like, 'You're crazy.'" The "Complicated" singer told "GMA" she's now abou...


Monday 29 June 2015

This Is the Weirdest Habit-Breaking Strategy

(Photo: Pablo Saldivia Salgado / EyeEm/Getty Images) By Melissa Dahl The latest episode of Psych Crunch, a new podcast hosted by Science of Us pal Christian Jarrett, is all about habits, and it includes a reference to what is maybe the weirdest habit-breaking strategy ever: Imagine your brain, say psychologists Kim Jenkins and Katy Tapper, is a city bus. Related: Changing a Habit Can Mess With Your Sense of Self This city bus is filled with noisy weirdos, as city buses often are; think of the noisy weirdos as your craving for chocolate, or the urge to bite your nails -- whatever habit you're trying to break. And you, they continue, are the driver of said bus. You can't help hearing the loud passengers, but you don't have to take direction from them; you are the one driving the bus. You'll...


Friday 26 June 2015

Save Wildlife, Save Yourself?

Protecting the environment may reduce many diseases, such as Lyme and West Nile, a study finds. The tantalizing idea suggests that conservation and human health may be more connected than we thought.» E-Mail This (Source: NPR Health and Science)


Thursday 25 June 2015

Alternative Lab Tests May Not Reliably Diagnose Lyme Disease Alternative Lab Tests May Not Reliably Diagnose Lyme Disease

Lyme disease diagnosed by alternative laboratory methods is indistinguishable by detailed clinical and laboratory evaluation from chronic fatigue syndrome, a case-control study suggests. Medscape Medical News (Source: Medscape Medical News Headlines)


Thursday 25 June 2015

Long-term Assessment of Health-Related Quality of Life in Patients With Culture-Confirmed Early Lyme Disease

The health-related quality of life of 100 subjects with culture-confirmed early Lyme disease enrolled in a prospective study with annual follow-up visits was evaluated using the 36-Item Short Form General Health Survey version 2 (SF-36v2) questionnaire at 11–20 years after diagnosis. The mean summary scores of physical and mental health were similar to those of the general population. (Source: Clinical Infectious Diseases)


Thursday 25 June 2015

Editorial Commentary: Life After Lyme Disease

(Source: Clinical Infectious Diseases)


Thursday 25 June 2015

Inhibition of the endosymbiont “Candidatus Midichloria mitochondrii” during 16S rRNA gene profiling reveals potential pathogens in Ixodes ticks from Australia

Conclusions: Abundant bacterial endosymbionts, such as CMM, limit the effectiveness of next-generation 16S bacterial community profiling in arthropods by masking less abundant bacteria, including pathogens. Specific blocking primers that inhibit endosymbiont 16S amplification during PCR are an effective way of reducing this limitation. Here, this strategy provided the first evidence of a relapsing fever Borrelia sp. and of novel “Candidatus Neoehrlichia” spp. in Australia. Our results raise new questions about tick-borne pathogens in I. holocyclus ticks. (Source: Parasites and Vectors)


Tuesday 23 June 2015

Parkinson disease: High infection burden in patients with Parkinson disease

Nature Reviews Neurology 11, 370 (2015). doi:10.1038/nrneurol.2015.112 Patients with Parkinson disease (PD) were found to be more likely to have evidence of viral and bacterial infections than were controls. Bu and colleagues assessed serum samples for antibodies against cytomegalovirus, Epstein–Barr virus, Borrelia burgdorferi, Helicobacter pylori and other pathogens. Seropositivity for (Source: Nature Reviews Neurology)


Friday 19 June 2015

Combination of Loop-Mediated Isothermal Amplification Assay and Nested PCR for Detection of Borrelia burgdorferi sensu lato in Human Serum Samples

Publication date: April 2015 Source:Biomedical and Environmental Sciences, Volume 28, Issue 4 Author(s): Liu Li ZHANG , Xue Xia HOU , Zhen GENG , Yong Liang LOU , Kang Lin WAN , Qin HAO A set of universal loop-mediated isothermal amplification (LAMP) primers targeting the fla gene was designed to detect Borrelia burgdorferi sensu lato (B. burgdorferi s.l.) in human samples. The sensitivity of LAMP was 20 copies/reaction, and the assay did not detect false positives among 11 other related bacteria. A positive LAMP result was obtained for 9 of the 24 confirmed cases and for 12 of 94 suspected cases. The positive rate of LAMP was the same as that of nested PCR. The LAMP is a useful diagnostic method that can be developed for rapid detection of B. burgdorferi s.l. in human sera. Combination ...

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Friday 19 June 2015

Borrelia burgdorferi sensu lato and co‐infections with Anaplasma phagocytophilum and Rickettsia spp. in Ixodes ricinus in Hamburg, Germany

Abstract To obtain initial data on Borrelia burgdorferi sensu lato (Spirochaetales: Spirochaetaceae) in Ixodes ricinus (Ixodida: Ixodidae) ticks in Hamburg, Germany, 1400 questing ticks were collected by flagging at 10 different public recreation areas in 2011 and analysed using probe‐based quantitative real‐time polymerase chain reaction. The overall rate of infection with B. burgdorferi s.l. was 34.1%; 30.0% of adults were infected (36.7% of females and 26.0% of males), as were 34.5% of nymphs. Significant differences in tick infection rates were observed between the spring and summer/autumn months, as well as among sampling locations. Borrelia genospecies identification by reverse line blotting was successful in 43.6% of positive tick samples. The most frequent genospecies was Borre...


Wednesday 17 June 2015

Borrelia burgdorferi clinical isolates induce human innate immune responses that are not dependent on genotype.

In conclusion, we demonstrate that the RST 1 and 3 isolates showed no distinction in their susceptibility to the various components of the human immune system studied here, suggesting that other factors are responsible for their differential invasiveness. PMID: 26093919 [PubMed - as supplied by publisher] (Source: Immunobiology)


Wednesday 17 June 2015

The Putative Role of Viruses, Bacteria, and Chronic Fungal Biotoxin Exposure in the Genesis of Intractable Fatigue Accompanied by Cognitive and Physical Disability

Abstract Patients who present with severe intractable apparently idiopathic fatigue accompanied by profound physical and or cognitive disability present a significant therapeutic challenge. The effect of psychological counseling is limited, with significant but very slight improvements in psychometric measures of fatigue and disability but no improvement on scientific measures of physical impairment compared to controls. Similarly, exercise regimes either produce significant, but practically unimportant, benefit or provoke symptom exacerbation. Many such patients are afforded the exclusionary, non-specific diagnosis of chronic fatigue syndrome if rudimentary testing fails to discover the cause of their symptoms. More sophisticated investigations often reveal the presence of a rang...


Monday 15 June 2015

Infection of Interleukin 17 Receptor A-Deficient C3H Mice with Borrelia burgdorferi Does Not Affect Their Development of Lyme Arthritis and Carditis [Host Response and Inflammation]

Recently, a number of studies have reported the presence of interleukin 17 (IL-17) in patients with Lyme disease, and several murine studies have suggested a role for this cytokine in the development of Lyme arthritis. However, the role of IL-17 has not been studied using the experimental Lyme borreliosis model of infection of C3H mice with Borrelia burgdorferi. In the current study, we investigated the role of IL-17 in the development of experimental Lyme borreliosis by infecting C3H mice devoid of the common IL-17 receptor A subunit (IL-17RA) and thus deficient in most IL-17 signaling. Infection of both C3H and C3H IL-17RA–/– mice led to the production of high levels of IL-17 in the serum, low levels in the heart tissue, and no detectable IL-17 in the joint tissue. The develo...

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Monday 15 June 2015

Macrophage Polarization during Murine Lyme Borreliosis [Host Response and Inflammation]

Infection of C3H mice with Borrelia burgdorferi, the causative agent of Lyme disease, reliably produces an infectious arthritis and carditis that peak around 3 weeks postinfection and then spontaneously resolve. Macrophage polarization has been suggested to drive inflammation, the clearance of bacteria, and tissue repair and resolution in a variety of infectious disease models. During Lyme disease it is clear that macrophages are capable of clearing Borrelia spirochetes and exhausted neutrophils; however, the role of macrophage phenotype in disease development or resolution has not been studied. Using classical (NOS2) and alternative (CD206) macrophage subset-specific markers, we determined the phenotype of F4/80+ macrophages within the joints and heart throughout the infection time course...


Friday 12 June 2015

Widespread Borrelia miyamotoi Tick-borne Fever Found in US Widespread Borrelia miyamotoi Tick-borne Fever Found in US

A new, and potentially more severe, infection transmitted by the same ticks that carry Lyme disease was much more common in the United States in 2013 than expected, especially in the Northeast. Medscape Medical News (Source: Medscape Infectious Diseases Headlines)

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Friday 12 June 2015

Geographical and Temporal Correlations in the Incidence of Lyme Disease, RMSF, Ehrlichiosis, and Coccidioidomycosis with Search Data

Authors: Vladimir Ratushny & Gideon P Smith (Source: Journal of Investigative Dermatology)


Friday 12 June 2015

Epidemiology of Lyme disease in low-incidence states

Publication date: Available online 12 June 2015 Source:Ticks and Tick-borne Diseases Author(s): Joseph D. Forrester , Meghan Brett , James Matthias , Danielle Stanek , Chasisity Brown Springs , Nicola Marsden-Haug , Hanna Oltean , JoDee Summers Baker , Kiersten J. Kugeler , Paul S. Mead , Alison Hinckley Lyme disease is the most common vector-borne disease in the U.S. Surveillance data from four states with a low-incidence of Lyme disease was performed. Most cases occurred after travel to high-incidence Lyme disease areas. Cases without travel-related exposure in low-incidence states differed epidemiologically; misdiagnosis may be common in these areas. (Source: Ticks and Tick borne Diseases)


Friday 12 June 2015

How far north are migrant birds transporting the tick Ixodes scapularis in Canada? Insights from stable hydrogen isotope analyses of feathers

Publication date: Available online 12 June 2015 Source:Ticks and Tick-borne Diseases Author(s): N.H. Ogden , I.K. Barker , C.A. Francis , A. Heagy , L.R. Lindsay , K.A. Hobson Lyme disease is emerging in Canada because of northward range expansion of the tick vector Ixodes scapularis. It is hypothesised that I. scapularis feeding on passerine birds migrating north in spring are important in founding new I. scapularis populations leading to northward range expansion. However, there are no studies on how far north I. scapularis may be carried, only inferences from passive tick surveillance. We used stable hydrogen isotope (δ2H) analysis of rectrices collected from northward migrating, I. scapularis-carrying, passerine birds captured in Canada to estimate how far north I. scapularis may be...


Thursday 11 June 2015

Teenager discovers new planet during work experience - video report

A Newcastle-under-Lyme school pupil has discovered a new planet while on a work placement. Tom Wagg, 17, was doing work experience with an astrophysics professor at Keele University when he spotted a minuscule dip in the light from a faraway star that he knew could be caused by a planet passing in front of it. Two years later the large gas form in the southern constellation of Hydra was confirmed as a planet Continue reading... (Source: Guardian Unlimited Science)


Thursday 11 June 2015

Schoolboy on work experience discovers planet

Newcastle-under-Lyme pupil Tom Wagg spotted dip in light which revealed existence of a planet while on placement at Keele University two years agoA schoolboy doing work experience with an astrophysics professor has discovered a new planet 1,000 light years from Earth.Newcastle-under-Lyme school pupil Tom Wagg was 15 when he went for his work placement at Keele University, where he spotted a minuscule dip in the light from a faraway star that he knew could be caused by a planet passing in front of it. Continue reading... (Source: Guardian Unlimited Science)


Thursday 11 June 2015

Ticks can transmit a new Lyme-like disease

There are several good reasons to keep ticks off your body. One is that they are creepy and suck your blood. Another is that they can transmit 14 different diseases—not just Lyme disease. A report published online this week in the journal Annals of Internal Medicine describes the newest tick-borne disease in North America, which is caused by a bacterium known as Borrelia miyamotoi. The microbe was first identified in Japan in 1995. The first report of it infecting humans came from Russia in 2011. Cases began appearing in the northeastern United States in 2013. Borrelia miyamotoi is a spiral-shaped bacterium that is related to the one that causes Lyme disease, another tick-borne infection. Infection with Borrelia miyamotoi often causes a recurring fever, as well as headache, muscle aches,...


Thursday 11 June 2015

Ticked Off--What We Don't Know About Lyme Disease

I didn’t see the tiny danger lurking in my own yard. Yet for Lyme disease awareness month, just ended, it seems I am learning experientially. I’ve had Lyme at least once before, and found three attached deer ticks on me just in 10 days. I may have had Lyme a second time, last year, but diagnostic tests are so poor that we don’t know. Here’s some of what I learned from my experience and for caring for others in my infectious disease practice. (Source: Forbes.com Healthcare News)


Wednesday 10 June 2015

Major emerging vector-borne zoonotic diseases of public health importance in Canada

Authors: Manisha A Kulkarni, Lea Berrang-Ford, Peter A Buck, Michael A Drebot, L Robbin Lindsay & Nicholas H Ogden (Source: Emerging Microbes and Infections)


Tuesday 9 June 2015

The List Of Tick-Transmitted Diseases Is Growing

WASHINGTON (AP) — Lyme disease makes the headlines but there are plenty of additional reasons to avoid tick bites. New research highlights the latest in a growing list of tick-borne threats — a distant relative of Lyme that's easy to confuse with other illnesses. Monday's study suggests a kind of bacteria with an unwieldy name — Borrelia miyamotoi — should be on the radar when people in Lyme-endemic areas get otherwise unexplained summertime fevers. It's one of several recently discovered diseases linked to ticks in different parts of the country, a reminder to get tick-savvy no matter where you live. "People need to be aware of what tick-borne diseases are in their area," says Dr. Peter J. Krause of Yale University, a specialist who reviewed the research. "And they should know h...

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Tuesday 9 June 2015

APHA Releases New Version of Control of Communicable Diseases Manual for Mobile and Web

The American Public Health Association and Unbound Medicine have announced the release of an updated version of Control of Communicable Diseases Manual for Mobile and Web that includes up-to-date information about the occurrence, transmission, resistance and control of communicable diseases. Free previews are available of chapters on Ebola, listeriosis, Lyme Disease, Rift Valley Fever and meningitis. (Source: PHPartners.org)


Tuesday 9 June 2015

Alabama Lyme Disease Association Has Representation on Commission...

Alabama Lyme Disease Association representative to serve on commission to study Lyme disease, and other tick-borne illnesses in Alabama(PRWeb June 09, 2015)Read the full story at http://www.prweb.com/releases/2015/06/prweb12775051.htm (Source: PRWeb: Medical Pharmaceuticals)


Tuesday 9 June 2015

Bay Area Lyme Foundation awards diagnostic grant to Harvard Medical School researchers

(DDC) Harvard Medical School research collaborators Nira Pollock, M.D., Ph.D., and John Branda, M.D. have just been awarded the 2015 Emerging Leader Award from Bay Area Lyme Foundation, the leading national nonprofit funder of innovative Lyme disease research. The $100,000 grant that accompanies this award will support research on a potential biomarker for Lyme disease, which may lead to the development of a novel urine test for early Lyme disease. (Source: EurekAlert! - Medicine and Health)


Tuesday 9 June 2015

Tick season health warning

Summer is peak season for ticks and the diseases they can spread. Lyme disease is the most well-known tick-borne illness, but it's not the only one to watch out for. Marlie Hall has more on what you need to know. (Source: Health News: CBSNews.com)


Tuesday 9 June 2015

Lyme disease not the only reason to avoid ticks

Researchers say a newly identified tick-borne disease may be on the rise in the northeastern U.S. (Source: Health News: CBSNews.com)

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Tuesday 9 June 2015

Response to Esteve-Gassent et al.: flaB sequences obtained from Texas PCR products are identical to the positive control strain Borrelia burgdorferi B31

Feria-Arroyo et al. had reported previously that, based on PCR analysis, 45 % of Ixodes scapularis ticks collected in Texas and Mexico were infected with the Lyme disease spirochete Borrelia burgdorferi (Parasit. Vectors 2014, 7:199). However, our analyses of their initial data (Parasit. Vectors 2014, 7:467) and a recent response by Esteve-Gassent et al. (Parasit. Vectors 2015, 8:129) provide evidence that the positive PCR results obtained from both ribosomal RNA intergenic sequences and the flagellin gene flaB are highly likely due to contamination by the B. burgdorferi B31 positive control strain. (Source: Parasites and Vectors)


Tuesday 9 June 2015

Prevent and manage Lyme disease with antibacterials based on patient characteristics, local causative species and disease manifestations

Abstract The optimal management of Lyme disease involves the use of antibacterials as prophylaxis and to treat manifestations of the disease. Treatment guidelines offer somewhat conflicting recommendations due to the absence of strong and compelling clinical evidence regarding the treatment of this disease. Ultimate treatment decisions should be made by the physician based on clinical judgement and the individual patient’s circumstances. (Source: Drugs and Therapy Perspectives)

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Tuesday 9 June 2015

New Tickborne Infection, More Common Than Once Believed, Circulating In Northeastern U.S.

While most of us are concerned about Lyme disease, a tickborne illness circulating during the spring and summertime in the Northeastern U.S, there is another, potentially more serious infection to be aware of as well. (Source: Forbes.com Healthcare News)



Friday 5 June 2015

Detection of Borrelia burgdorferi and Anaplasma phagocytophilum in the black‐legged tick, Ixodes scapularis, within southwestern Pennsylvania

ABSTRACT Prevalence studies of Borrelia burgdorferi and Anaplasma phagocytophilum have been rare for ticks from southwestern Pennsylvania. We collected 325 Ixodes scapularis ticks between 2011 and 2012 from four counties in southwestern Pennsylvania. We tested for the presence of Borrelia burgdorferi and Anaplasma phagocytophilum using PCR. Of the ticks collected from Pennsylvania, B. burgdorferi (causative agent of Lyme disease) was present in 114/325 (35%) and Anaplasma phagocytophilum (causative agent of Human Granulocytic Anaplasmosis) was present in 48/325 (15%) as determined by PCR analysis. (Source: Journal of Vector Ecology)



Thursday 4 June 2015

Lyme carditis--diagnosis, treatment and prognosis.

CONCLUSION: Lyme carditis is among the rarer manifestations of Lyme borreliosis but must nevertheless be considered prominently in differential diagnosis because of the potentially severe cardiac arrhythmias that it can cause. PMID: 25838022 [PubMed - in process] (Source: Deutsches Arzteblatt International)

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Thursday 4 June 2015

Bullying Borrelia: when the culture of science is under attack.

Authors: Auwaerter PG, Melia MT Abstract Although Lyme disease responds to short courses of antibiotics, tick-borne Borrelia burgdorferi has been advanced by some as a frequent explanation for medically unexplained symptoms such as continual fatigue, musculoskeletal pains, and subjective neurocognitive dysfunction. Often called "chronic Lyme disease" by adherents of this philosophy, it is loosely defined, and practitioners liberally prescribe nostrums, including prolonged antimicrobial therapies, in a belief that this eradicates suspected infection. Perhaps due to the lack of supportive data, proponents of this theory have developed their own meetings, literature, activist groups, and substantial internet activities to advance their views. Forces motivating this movement are explor...


Wednesday 3 June 2015

The prevalence of Anaplasma phagocytophilum in questing Ixodes ricinus ticks in SW Poland.

Authors: Kiewra D, Zaleśny G, Czułowska A Abstract Ticks constitute important vectors of human and animal pathogens. Besides the Lyme borreliosis and tick-borne encephalitis, other pathogens such as Babesia spp., Rickettsia spp., and Anaplasma phagocytophilum, are of increasing public health interest. In Poland, as in other European countries, Ixodes ricinus, the most prevalent tick species responsible for the majority of tick bites in humans, is the main vector of A. phagocytophilum. The aim of the study was to estimate the infection level of I. ricinus with A. phagocytophilum in selected districts, not previously surveyed for the presence of this agent. Sampling of questing ticks was performed in 12 forested sites, located in four districts (Legnica, Milicz, Lubań, and Oława)...


Wednesday 3 June 2015

Cross-border surveillance differences: tick-borne encephalitis and lyme borreliosis in the Czech Republic and Poland, 1999-2008.

Authors: Stefanoff P, Orliková H, Príkazský V, Bene C, Rosińska M Abstract We compared neighbouring regions of the Czech Republic (CZ) and Poland (PL) situated within 100 km of the country border, in order to compare surveillance systems performance in measuring the burden of tick-borne diseases in both countries. We used routine surveillance notifications from 1999-2008 on tick-borne encephalitis (TBE) and Lyme borreliosis (LB). We assessed the crude risk ratio (RR) across the country border, and its estimates adjusted for both population density and the expected epidemiological gradient across the region, using negative binomial regression. The crude RR between CZ and PL was 7.43 (95% Cl 6.20-8.90) for TBE, and 1.80 (1.76-1.83) for LB. The adjusted RR for TBE increased from 4...


Wednesday 3 June 2015

[Epidemiology of Lyme disease in a healthcare area in north-west Spain].

CONCLUSIONS: Due to the increase of the disease in north-west Spain and the differences observed between the different areas, epidemiological studies are needed that increase the index of diagnostic suspicion and lead to the implementation of effective prevention measures. PMID: 25726250 [PubMed - in process] (Source: Gaceta Sanitaria)


Wednesday 3 June 2015

Recent-onset dilated cardiomyopathy associated with Borrelia burgdorferi infection.

CONCLUSION: Targeted antibiotic treatment of Bb-related recent-onset DCM in addition to conventional heart failure therapy is associated with favorable cardiac remodeling and improvement of heart failure symptoms. PMID: 25939436 [PubMed - as supplied by publisher] (Source: Herz)

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Wednesday 3 June 2015

Identification of new compounds with high activity against stationary phase Borrelia burgdorferi from the NCI compound collection

Authors: Jie Feng, Wanliang Shi, Shuo Zhang & Ying Zhang (Source: Emerging Microbes and Infections)


Tuesday 2 June 2015

Your NEJM Group Today: Disseminated Lyme Image, Sumatriptan & Migraine with Aura, Boston Hospitalist Opportunity (FREE)

By the Editors NEJM Group offers so many valuable resources for practicing clinicians. Here's what we chose for you today:NEJM Clinical Practice Center: Check out … (Source: Physician's First Watch current issue)


Monday 1 June 2015

My Daughter's Mysterious Illness -- And My Own

For TueNight.com by Allison Czarnecki (Photos: Courtesy Allison Czarnecki. Photos from left to right: Allison and her daughter as a baby, Allison's daughter in the hospital getting tests, Allison's daughter now; Photo collage: Helen Jane Hearn/TueNight.com) Exactly one year ago, my teenage daughter got sick. Really sick. One day, out of the blue, she woke up and couldn't get out of bed. Up to this point, my then 14-year-old daughter had been a wildly healthy, state-championship swimmer who played the cello in an honors orchestra, earned straight As in all her classes. She was heavily involved in leadership positions in our church and in an assortment of other extracurricular activities at school and in the community. She's beautiful, talented, smart, kind, friendly, and if you were to ...


Monday 1 June 2015

Researchers' discovery may explain difficulty in treating Lyme disease

The bac­terium that causes Lyme dis­ease forms dor­mant per­sister cells, which are known to evade antibi­otics, researchers have discovered. This sig­nif­i­cant finding, they said, could help explain why it's so dif­fi­cult to treat the infec­tion in some patients. (Source: ScienceDaily Headlines)


Monday 1 June 2015

Borrelia burgdorferi sensu lato and co‐infections with Anaplasma phagocytophilum and Rickettsia spp. in Ixodes ricinus in Hamburg, Germany

Abstract To obtain initial data on Borrelia burgdorferi sensu lato (Spirochaetales: Spirochaetaceae) in Ixodes ricinus (Ixodida: Ixodidae) ticks in Hamburg, Germany, 1400 questing ticks were collected by flagging at 10 different public recreation areas in 2011 and analysed using probe‐based quantitative real‐time polymerase chain reaction. The overall rate of infection with B. burgdorferi s.l. was 34.1%; 30.0% of adults were infected (36.7% of females and 26.0% of males), as were 34.5% of nymphs. Significant differences in tick infection rates were observed between the spring and summer/autumn months, as well as among sampling locations. Borrelia genospecies identification by reverse line blotting was successful in 43.6% of positive tick samples. The most frequent genospecies was Bor...


Monday 1 June 2015

Sinus Pause in Association with Lyme Carditis.

We report the unusual case of a 59-year-old man who presented with new-onset symptomatic sinus pauses one month after hiking in upstate New York. To our knowledge, this is the first case report from North America that describes the relationship between symptomatic sinus pause and Lyme carditis. PMID: 26175640 [PubMed - in process] (Source: Texas Heart Institute Journal)

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Monday 1 June 2015

Efficacy and safety of pharmacological treatments for acute Lyme neuroborreliosis – a systematic review

ConclusionsEvidence regarding pharmacological treatment of acute Lyme neuroborreliosis is scarce and therefore insufficient to recommend preference of beta‐lactam antibiotics over doxycycline or vice versa. However, due to considerable imprecision, relevant differences between treatments cannot be excluded. No evidence suggesting benefits of extended antibiotic treatments could be identified. Further well‐designed trials are needed. Individual treatment decisions should address patients' preferences and individual conditions like prior allergic reactions. (Source: European Journal of Neurology)


Monday 1 June 2015

Seroprevalence of equine granulocytic anaplasmosis and lyme borreliosis in Canada as determined by a point-of-care enzyme-linked immunosorbent assay (ELISA).

Authors: Schvartz G, Epp T, Burgess HJ, Chilton NB, Pearl DL, Lohmann KL Abstract Equine granulocytic anaplasmosis (EGA) and Lyme borreliosis (LB) are an emerging concern in Canada. We estimated the seroprevalence of EGA and equine LB by testing 376 convenience serum samples from 3 provinces using a point-of-care SNAP(®) 4Dx(®) ELISA (IDEXX Laboratories, Westbrook, Maine, USA), and investigated the agreement between the point-of-care ELISA and laboratory-based serologic tests. The estimated seroprevalence for EGA was 0.53% overall (0.49% in Saskatchewan, 0.71% in Manitoba), while the estimated seroprevalence for LB was 1.6% overall (0.49% in Saskatchewan, 2.86% in Manitoba). There was limited agreement between the point-of-care ELISA and an indirect fluorescent antibody test for ...


Saturday 30 May 2015

Association between body size and reservoir competence of mammals bearing Borrelia burgdorferi at an endemic site in the northeastern United States

Conclusions: These empirical findings as well as inferences from modeling suggest that small mammals on the basis of their sizes are more competent as reservoirs of B. burgdorferi in this environment than medium-to large-sized mammals. (Source: Parasites and Vectors)


Wednesday 27 May 2015

Disseminated Lyme Disease

New England Journal of Medicine, Volume 372, Issue 22, Page 2136-2136, May 2015. (Source: New England Journal of Medicine)


Wednesday 27 May 2015

Ticks and tick-borne pathogens in South Bohemia (Czech Republic) – Spatial variability in Ixodes ricinus abundance, Borrelia burgdorferi and tick-borne encephalitis virus prevalence

Publication date: Available online 27 April 2015 Source:Ticks and Tick-borne Diseases Author(s): V. Hönig , P. Svec , P. Halas , Z. Vavruskova , H. Tykalova , P. Kilian , V. Vetiskova , V. Dornakova , J. Sterbova , Z. Simonova , J. Erhart , J. Sterba , M. Golovchenko , N. Rudenko , L. Grubhoffer Spatial distribution of Ixodes ricinus tick host-seeking activity, as well as prevalence of Borrelia burgdorferi sensu lato and tick-borne encephalitis virus (TBEV) were studied in the TBE endemic area of South Bohemia (Czech Republic). High variability in tick abundance detected in a network of 30 study sites was most closely associated with characteristics of vegetation cover. Of 11,182 tested tick samples, 12% carried DNA of spirochete from B. burgdorferi s.l. complex. B. afzelii and B. garin...


Wednesday 27 May 2015

Tick-borne bacteria in Ixodes ricinus collected in southern Norway evaluated by a commercial kit and established real-time PCR protocols

Publication date: Available online 28 April 2015 Source:Ticks and Tick-borne Diseases Author(s): H. Quarsten , T. Skarpaas , L. Fajs , S. Noraas , V. Kjelland Ticks are important vectors of human pathogens. The knowledge of disease causing agents harboured by ticks in Norway is limited. The focus of this study was (a) to detect the bacteria of medical importance in ticks collected from the vegetation at locations in the southern part of the country and (b) to evaluate a novel commercially available multiplex PCR based method by comparing results with conventional established real-time PCR protocols. Borrelia burgdorferi sensu lato was confirmed to be the most prevalent pathogen detected (31%) among one hundred individually analysed adult ticks. Borrelia miyamotoi, a spirochete associated...


Wednesday 27 May 2015

Broad diversity of host responses of the white-footed mouse Peromyscus leucopus to Borrelia infection and antigens

Publication date: Available online 28 April 2015 Source:Ticks and Tick-borne Diseases Author(s): Vanessa Cook , Alan G. Barbour Peromyscus leucopus, the white-footed mouse, is one of the more abundant mammals of North America and is a major reservoir host for at least five tickborne diseases of humans, including Lyme disease and a newly-recognized form of relapsing fever. In comparison to Mus musculus, which is not a natural reservoir for any of these infections, there has been little research on experimental infections in P. leucopus. With the aim of further characterizing the diversity of phenotypes of host responses, we studied a selection of quantitative traits in colony-bred and -reared outbred P. leucopus adults that were uninfected, infected with the relapsing fever agent Borrelia...

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Wednesday 27 May 2015

Climate change influences on the annual onset of Lyme disease in the United States

Publication date: Available online 15 May 2015 Source:Ticks and Tick-borne Diseases Author(s): Andrew J. Monaghan , Sean M. Moore , Kevin M. Sampson , Charles B. Beard , Rebecca J. Eisen Lyme disease is the most commonly reported vector-borne illness in the United States. Lyme disease occurrence is highly seasonal and the annual springtime onset of cases is modulated by meteorological conditions in preceding months. A meteorological-based empirical model for Lyme disease onset week in the United States is driven with downscaled simulations from five global climate models and four greenhouse gas emissions scenarios to project the impacts of 21st century climate change on the annual onset week of Lyme disease. Projections are made individually and collectively for the 12 eastern States whe...


Monday 25 May 2015

Unorthodox Alternative Therapies Marketed to Treat Lyme Disease

Conclusions. Providers of alternative therapies commonly target patients who believe they have Lyme disease. The efficacy of these unconventional treatments for Lyme disease is not supported by scientific evidence, and in many cases they are potentially harmful. (Source: Clinical Infectious Diseases)


Monday 25 May 2015

Development of a Metabolic Biosignature for Detection of Early Lyme Disease

Conclusions. The data provide proof-of-concept that metabolic profiling for early Lyme disease can achieve significantly greater (P < .0001) diagnostic sensitivity than current 2-tier serology, while retaining high specificity. (Source: Clinical Infectious Diseases)



Friday 22 May 2015

Oligoarthritis Caused by Borrelia bavariensis, Austria, 2014.

Authors: Markowicz M, Ladstatter S, Schotta AM, Reiter M, Pomberger G, Stanek G Abstract A case of Lyme oligoarthritis occurred in an 11-year-old boy in Vienna, Austria. DNA of Borrelia bavariensis was detected by PCR in 2 aspirates obtained from different joints. Complete recovery was achieved after a 4-week course with amoxicillin. Lyme arthritis must be considered in patients from Europe who have persisting joint effusions. PMID: 25992945 [PubMed - in process] (Source: Emerging Infectious Diseases)

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Thursday 21 May 2015

Delayed Onset of the Jarisch–Herxheimer Reaction in Doxycycline-Treated Disease: A Case Report and Review of its Histopathology and Implications for Pathogenesis

Abstract: The Jarisch–Herxheimer reaction (JHR) is a transient inflammatory syndrome triggered hours after the start of antibiotic treatment of spirochete infections, namely syphilis. Clinically, JHR manifests as an abrupt onset of constitutional symptoms and exacerbation of cutaneous lesions that resolve without intervention. JHR's pathogenesis is unclear and it is histopathologically rarely reported. Herein, the authors report a 47-year-old woman, with solitary erythema migrans and positive Lyme disease serology, who presented for medical care 14 days after commencement of doxycycline therapy. She complained of malaise, facial flushing, gingival erythema, and acquisition of additional plaques characterized by swelling, increased erythema, pruritus, and exfoliative scale. Punch biopsies...


Wednesday 20 May 2015

Changes in antibody reactivity to Borrelia burgdorferi three months after a tick bite. A cohort of 1,886 persons.

In conclusion, 5.4% of people with tick bites developed a rise in borrelia-specific antibodies above the 2.5% percentile in either ELISA assay, but only 40 (2.1%) developed clinical Lyme borreliosis. PMID: 25994550 [PubMed - as supplied by publisher] (Source: Clinical and Vaccine Immunology)


Tuesday 19 May 2015

Erythema Migrans

Erythema migrans (EM) is the most common objective manifestation of Borrelia burgdorferi infection. Systemic symptoms are usually present. Most patients do not recall a preceding tick bite. Despite a characteristic appearance, EM is not pathognomonic for Lyme disease and must be distinguished from other similar appearing skin lesions. EM is a clinical diagnosis; serologic and PCR assays are unnecessary. Leukopenia and thrombocytopenia are indicative of either an alternative diagnosis, or coinfection with another tick-borne pathogen. When EM is promptly treated with appropriate antimicrobial agents, the prognosis is excellent. Persons in endemic areas should take measures to prevent tick bites. (Source: Infectious Diseases Clinics of North America)


Tuesday 19 May 2015

Nervous System Lyme Disease

Lymphocytic meningitis, cranial neuritis or radiculoneuritis occur in up to 15% of patients with untreated Borrelia burgdorferi infection. Presentations of multifocal PNS involvement can range from painful monoradiculitis to confluent mononeuropathy multiplex. Serologic testing is highly accurate after 4 to 6 weeks of infection. In CNS infection, production of anti-B burgdorferi antibody is often demonstrable in CSF. Oral antimicrobials are microbiologically curative in virtually all patients, including acute European neuroborreliosis. Severe cases may require parenteral treatment. The fatigue and cognitive symptoms seen in some patients with extra-neurological disease are neither evidence of CNS infection nor specific to Lyme disease. (Source: Infectious Diseases Clinics of North America)


Tuesday 19 May 2015

Lyme Carditis

Lyme disease is a common disease that uncommonly affects the heart. Because of the rarity of this diagnosis and the frequent absence of other concurrent clinical manifestations of early Lyme disease, consideration of Lyme carditis demands a high level of suspicion when patients in endemic areas come to attention with cardiovascular symptoms and evidence of higher-order heart block. A majority of cases manifest as atrioventricular block. A minority of Lyme carditis cases are associated with myopericarditis. Like other manifestations of Lyme disease, carditis can readily be managed with antibiotic therapy and supportive care measures, such that affected patients almost always completely recover. (Source: Infectious Diseases Clinics of North America)

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Tuesday 19 May 2015

Diagnosis and Treatment of Lyme Arthritis

This article reviews the clinical manifestations, diagnosis, and management of Lyme arthritis. (Source: Infectious Diseases Clinics of North America)


Tuesday 19 May 2015

Laboratory Diagnosis of Lyme Disease

The majority of laboratory tests performed for the diagnosis of Lyme disease are based on detection of the antibody responses against B burgdorferi in serum. The sensitivity of antibody-based tests increases with the duration of the infection. Patients early in their illness are more likely to have a negative result. There is a need to simplify the testing algorithm for Lyme disease, improving sensitivity in early disease while still maintaining high specificity and providing information about the stage of infection. The development of a point of care assay and biomarkers for active infection would be major advances for the field. (Source: Infectious Diseases Clinics of North America)


Tuesday 19 May 2015

Chronic Lyme Disease

Chronic Lyme disease is a poorly defined diagnosis that is usually given to patients with prolonged, unexplained symptoms or with alternative medical diagnoses. Data do not support the proposition that chronic, treatment-refractory infection with Borrelia burgdorferi is responsible for the many conditions that get labeled as chronic Lyme disease. Prolonged symptoms after successful treatment of Lyme disease are uncommon, but in rare cases may be severe. Prolonged courses of antibiotics neither prevent nor ameliorate these symptoms and are associated with considerable harm. (Source: Infectious Diseases Clinics of North America)


Tuesday 19 May 2015

Human Granulocytic Anaplasmosis

Human granulocytic anaplasmosis, a deer tick–transmitted rickettsial infection caused by Anaplasma phagocytophilum, is a common cause of undifferentiated fever in the northeast and upper Midwest United States. Patients are often initially diagnosed with a mild viral infection, and illness readily resolves in most cases. However, as many as 3% develop life-threatening complications and nearly 1% die from the infection. Although coinfections with Borrelia burgdorferi and Babesia microti occur, there is little evidence to suggest synergism of disease or a role for A phagocytophilum in chronic illness. No vaccine is available. (Source: Infectious Diseases Clinics of North America)


Tuesday 19 May 2015

Epidemiology of Lyme Disease

Lyme disease is the most common vector-borne illness in North America and Europe. The etiologic agent, Borrelia burgdorferi sensu lato, is transmitted to humans by certain species of Ixodes ticks, which are found widely in temperate regions of the Northern hemisphere. Clinical features are diverse, but death is rare. The risk of human infection is determined by the geographic distribution of vector tick species, ecologic factors that influence tick infection rates, and human behaviors that promote tick bite. Rates of infection are highest among children 5 to 15 years old and adults older than 50 years. (Source: Infectious Diseases Clinics of North America)

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Tuesday 19 May 2015

Lyme Disease in Children

The diagnosis and management of Lyme disease in children is similar to that in adults with a few clinically relevant exceptions. The use of doxycycline as an initial empiric choice is to be avoided for children 8 years old and younger. Children may present with insidious onset of elevated intracranial pressure during acute disseminated Lyme disease; prompt diagnosis and treatment of this condition is important to prevent loss of vision. Children who acquire Lyme disease have an excellent prognosis even when they present with the late disseminated manifestation of Lyme arthritis. Guidance on the judicious use of serologic tests is provided. Pediatricians and family practitioners should be familiar with the prevention and management of tick bites, which are common in children. (Source: Infe...


Tuesday 19 May 2015

Posttreatment Lyme Disease Syndrome

The prognosis following appropriate antibiotic treatment of early or late Lyme disease is favorable but can be complicated by persistent symptoms of unknown cause termed posttreatment Lyme disease syndrome (PTLDS), characterized by fatigue, musculoskeletal pain, and cognitive complaints that persist for 6 months or longer after completion of antibiotic therapy. Risk factors include delayed diagnosis, increased severity of symptoms, and presence of neurologic symptoms at time of initial treatment. Two-tier serologic testing is neither sensitive nor specific for diagnosis of PTLDS because of variability in convalescent serologic responses after treatment of early Lyme disease. Optimal treatment of PTLDS awaits more precise understanding of the pathophysiologic mechanisms involved in this il...


Tuesday 19 May 2015

Lyme Disease: Knowing Good Evidence to Help Inform Practice

Depending on the clinical situation and presence or absence of preconceived notions, evaluations for Lyme disease can range from efficient visits solved with a short course of antibiotic therapy to involved encounters that include a review of long-standing, nonspecific symptoms such as fatigue and pain that are less likely to represent an active infection. While the majority of patients with authentic Lyme disease improve with treatment, some have a slower resolution of symptoms and still others appear to have problems persisting beyond 6 months, which is called posttreatment Lyme disease syndrome (PTLDS). (Source: Infectious Diseases Clinics of North America)


Tuesday 19 May 2015

Lyme Disease and Other Infections Transmitted by

INFECTIOUS DISEASE CLINICS OF NORTH AMERICA (Source: Infectious Diseases Clinics of North America)


Tuesday 19 May 2015

Lyme Carditis

Publication date: June 2015 Source:Infectious Disease Clinics of North America, Volume 29, Issue 2 Author(s): Matthew L. Robinson , Takaaki Kobayashi , Yvonne Higgins , Hugh Calkins , Michael T. MeliaTeaser Lyme disease is a common disease that uncommonly affects the heart. Because of the rarity of this diagnosis and the frequent absence of other concurrent clinical manifestations of early Lyme disease, consideration of Lyme carditis demands a high level of suspicion when patients in endemic areas come to attention with cardiovascular symptoms and evidence of higher-order heart block. A majority of cases manifest as atrioventricular block. A minority of Lyme carditis cases are associated with myopericarditis. Like other manifestations of Lyme disease, carditis can readily be managed with...

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Tuesday 19 May 2015

Epidemiology of Lyme Disease

Publication date: June 2015 Source:Infectious Disease Clinics of North America, Volume 29, Issue 2 Author(s): Paul S. MeadTeaser Lyme disease is the most common vector-borne illness in North America and Europe. The etiologic agent, Borrelia burgdorferi sensu lato, is transmitted to humans by certain species of Ixodes ticks, which are found widely in temperate regions of the Northern hemisphere. Clinical features are diverse, but death is rare. The risk of human infection is determined by the geographic distribution of vector tick species, ecologic factors that influence tick infection rates, and human behaviors that promote tick bite. Rates of infection are highest among children 5 to 15 years old and adults older than 50 years. (Source: Infectious Disease Clinics of North America)


Tuesday 19 May 2015

Lyme Disease: Knowing Good Evidence to Help Inform Practice

Publication date: June 2015 Source:Infectious Disease Clinics of North America, Volume 29, Issue 2 Author(s): Paul G. Auwaerter (Source: Infectious Disease Clinics of North America)


Tuesday 19 May 2015

Lyme Disease and Other Infections Transmitted by Ixodes scapularis

Publication date: June 2015 Source:Infectious Disease Clinics of North America, Volume 29, Issue 2 Author(s): Paul G. Auwaerter (Source: Infectious Disease Clinics of North America)

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Tuesday 19 May 2015

Laboratory Diagnosis of Lyme Disease Advances and Challenges

Publication date: June 2015 Source:Infectious Disease Clinics of North America, Volume 29, Issue 2 Author(s): Adriana R. MarquesTeaser The majority of laboratory tests performed for the diagnosis of Lyme disease are based on detection of the antibody responses against B burgdorferi in serum. The sensitivity of antibody-based tests increases with the duration of the infection. Patients early in their illness are more likely to have a negative result. There is a need to simplify the testing algorithm for Lyme disease, improving sensitivity in early disease while still maintaining high specificity and providing information about the stage of infection. The development of a point of care assay and biomarkers for active infection would be major advances for the field. (Source: Infectious Dise...


Tuesday 19 May 2015

Human Granulocytic Anaplasmosis

Publication date: June 2015 Source:Infectious Disease Clinics of North America, Volume 29, Issue 2 Author(s): Johan S. Bakken , J. Stephen DumlerTeaser Human granulocytic anaplasmosis, a deer tick–transmitted rickettsial infection caused by Anaplasma phagocytophilum, is a common cause of undifferentiated fever in the northeast and upper Midwest United States. Patients are often initially diagnosed with a mild viral infection, and illness readily resolves in most cases. However, as many as 3% develop life-threatening complications and nearly 1% die from the infection. Although coinfections with Borrelia burgdorferi and Babesia microti occur, there is little evidence to suggest synergism of disease or a role for A phagocytophilum in chronic illness. No vaccine is available. (Source: Infe...


Tuesday 19 May 2015

Diagnosis and Treatment of Lyme Arthritis

This article reviews the clinical manifestations, diagnosis, and management of Lyme arthritis. (Source: Infectious Disease Clinics of North America)


Tuesday 19 May 2015

Chronic Lyme Disease

Publication date: June 2015 Source:Infectious Disease Clinics of North America, Volume 29, Issue 2 Author(s): Paul M. LantosTeaser Chronic Lyme disease is a poorly defined diagnosis that is usually given to patients with prolonged, unexplained symptoms or with alternative medical diagnoses. Data do not support the proposition that chronic, treatment-refractory infection with Borrelia burgdorferi is responsible for the many conditions that get labeled as chronic Lyme disease. Prolonged symptoms after successful treatment of Lyme disease are uncommon, but in rare cases may be severe. Prolonged courses of antibiotics neither prevent nor ameliorate these symptoms and are associated with considerable harm. (Source: Infectious Disease Clinics of North America)

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Tuesday 19 May 2015

Nervous System Lyme Disease

Publication date: June 2015 Source:Infectious Disease Clinics of North America, Volume 29, Issue 2 Author(s): John J. HalperinTeaser Lymphocytic meningitis, cranial neuritis or radiculoneuritis occur in up to 15% of patients with untreated Borrelia burgdorferi infection. Presentations of multifocal PNS involvement can range from painful monoradiculitis to confluent mononeuropathy multiplex. Serologic testing is highly accurate after 4 to 6 weeks of infection. In CNS infection, production of anti-B burgdorferi antibody is often demonstrable in CSF. Oral antimicrobials are microbiologically curative in virtually all patients, including acute European neuroborreliosis. Severe cases may require parenteral treatment. The fatigue and cognitive symptoms seen in some patients with extra-neurolog...


Tuesday 19 May 2015

Lyme Disease in Children

Publication date: June 2015 Source:Infectious Disease Clinics of North America, Volume 29, Issue 2 Author(s): Sunil K. SoodTeaser The diagnosis and management of Lyme disease in children is similar to that in adults with a few clinically relevant exceptions. The use of doxycycline as an initial empiric choice is to be avoided for children 8 years old and younger. Children may present with insidious onset of elevated intracranial pressure during acute disseminated Lyme disease; prompt diagnosis and treatment of this condition is important to prevent loss of vision. Children who acquire Lyme disease have an excellent prognosis even when they present with the late disseminated manifestation of Lyme arthritis. Guidance on the judicious use of serologic tests is provided. Pediatricians and f...


Tuesday 19 May 2015

Erythema Migrans

Publication date: June 2015 Source:Infectious Disease Clinics of North America, Volume 29, Issue 2 Author(s): Robert B. NadelmanTeaser Erythema migrans (EM) is the most common objective manifestation of Borrelia burgdorferi infection. Systemic symptoms are usually present. Most patients do not recall a preceding tick bite. Despite a characteristic appearance, EM is not pathognomonic for Lyme disease and must be distinguished from other similar appearing skin lesions. EM is a clinical diagnosis; serologic and PCR assays are unnecessary. Leukopenia and thrombocytopenia are indicative of either an alternative diagnosis, or coinfection with another tick-borne pathogen. When EM is promptly treated with appropriate antimicrobial agents, the prognosis is excellent. Persons in endemic areas shou...


Tuesday 19 May 2015

Posttreatment Lyme Disease Syndrome

Publication date: June 2015 Source:Infectious Disease Clinics of North America, Volume 29, Issue 2 Author(s): John N. AucottTeaser The prognosis following appropriate antibiotic treatment of early or late Lyme disease is favorable but can be complicated by persistent symptoms of unknown cause termed posttreatment Lyme disease syndrome (PTLDS), characterized by fatigue, musculoskeletal pain, and cognitive complaints that persist for 6 months or longer after completion of antibiotic therapy. Risk factors include delayed diagnosis, increased severity of symptoms, and presence of neurologic symptoms at time of initial treatment. Two-tier serologic testing is neither sensitive nor specific for diagnosis of PTLDS because of variability in convalescent serologic responses after treatment of ea...


Tuesday 19 May 2015

Cerebrovascular Events in Lyme Neuroborreliosis

Cerebrovascular events in neuroborreliosis are a rare condition described only in isolated or small case series. No specific clinical or radiological features have been identified, and diagnosis is based on very different criteria. (Source: Journal of Stroke and Cerebrovascular Diseases)


Monday 18 May 2015

[Correspondence] Infectious causes of stroke

We read with great interest the excellent Review by Jennifer Fugate and colleagues1 about the infectious causes of stroke. Their Review is useful for daily practice, since physicians often focus excessively on autoimmune causes of central nervous system vasculitis causing stroke, while forgetting about infectious causes. However, we think that apart from neurosyphilis, which is mentioned in great detail, an additional comment on stroke caused by another spirochetal disease, Lyme neuroborreliosis, is needed. (Source: The Lancet Infectious Diseases)


Friday 15 May 2015

The chemokine CXCL13 is elevated in the cerebrospinal fluid of patients with neurosyphilis

Background: The chemokine CXCL13 has been discussed as a diagnostic parameter with high specificity for Lyme neuroborreliosis (LNB) and as a marker of disease activity. Neurosyphilis and LNB share similar characteristics. We investigated retrospectively CXCL13 levels in the cerebrospinal fluid (CSF) of patients with neurosyphilis at initial diagnosis and during treatment. Results: Five patients with neurosyphilis were identified retrospectively using an electronic database in a tertiary care hospital from 2005 to 2012. CXCL13 levels were measured using an ELISA. Five patients with definite LNB and 10 patients with multiple sclerosis (MS) served as controls. Median CXCL13 levels at baseline were 972 pg/mL for neurosyphilis patients, 8,000 pg/mL for LNB patients, and 7.8 pg/mL ...

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Friday 15 May 2015

Tick sialostatins L and L2 differentially influence dendritic cell responses to Borrelia spirochetes

Conclusions: This study shows that DC responses to Borrelia spirochetes are affected by tick cystatins. Sialo L influences the maturation of DC thus having impact on adaptive immune response. Sialo L2 affects the production of chemokines potentially engaged in the development of inflammatory response. The impact of cystatins on Borrelia growth in vivo is discussed. (Source: Parasites and Vectors)


Thursday 14 May 2015

Chronic Lyme disease

Halperin JJ (Source: Infection and Drug Resistance)


Wednesday 13 May 2015

First U.S. Center to Study Lyme Disease Launched at Johns Hopkins Medicine - 5/13/15

Fundamental research into the causes and cures of post-treatment Lyme disease syndrome now has its first home base at a major U.S. medical research center with the launch of the Johns Hopkins Lyme Disease Clinical Research Center. (Source: Johns Hopkins Medicine News)


Wednesday 13 May 2015

Space agency targets 'tick disease'

The European Space Agency gives financial backing to a Scottish project to use an app to map tick hotspots and tackle Lyme disease. (Source: BBC News | Health | UK Edition)


Wednesday 13 May 2015

TICKED (Calendula Officinalis, Phytolacca Decandra, Borrelia Burgdorferi, Adrenalinum, Ledum Palustre, Aconitum Napellus, Arnica Montana,) Liquid [Apotheca Company]

Updated Date: May 13, 2015 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))


Wednesday 13 May 2015

Deep Sequencing Analysis of the Ixodes ricinus Haemocytome

Conclusions/significance This is the first systems biology approach to describe the genes expressed in the haemocytes of this neglected disease vector. A total of 2,860 coding sequences were deposited to GenBank, increasing to 27,547 the number so far deposited by our previous transcriptome studies that serves as a discovery platform for studies with I. ricinus biochemistry and physiology. (Source: PLoS Neglected Tropical Diseases)


Wednesday 13 May 2015

Cross-reactive epitopes in Borrelia burgdorferi p66.

Authors: Arnaboldi PM, Dattwyler RJ Abstract Epitope mapping of the p66 outer membrane protein of Borrelia burgdorferi revealed that the protein contains numerous cross-reactive linear epitopes recognized by serum antibody in the majority of individuals tested, regardless of Lyme disease history, limiting the usefulness of this antigen in Lyme disease serodiagnostic assays. PMID: 25972406 [PubMed - as supplied by publisher] (Source: Clinical and Vaccine Immunology)

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Wednesday 13 May 2015

Mayo Clinic News Network Headline 5/13/15

In today's Mayo Clinic News Network Headline with Vivien Williams: Ticks: These disease-carrying parasites are responsible for more than 30,000 cases of Lyme disease each year, according to the Centers for Disease Control and Prevention (CDC). Mayo Clinic parasitologist Dr. Bobbi Pritt offers tips on how to prevent tick bites and what to do in case one embeds into [...] (Source: News from Mayo Clinic)


Wednesday 13 May 2015

Vaccination with ospA-/ospB- Borrelia burgdorferi Strain 50772 Provides Significant Protection against Canine Lyme Disease.

Authors: Callister SM, LaFleur RL, Dant JC, Wasmoen TL, Jobe DA, Lovrich SD Abstract Beagles received placebo or ospA(-)/ospB(-) B. burgdorferi before tick-challenge. Twenty-eight (41%) ticks and skin from control dogs (n = 10) contained B. burgdorferi. In contrast, 12 (19%) ticks from 10 vaccine-recipients were infected (P = 0.0077) and 5 dogs yielded spirochetes from skin (P = 0.0325). In addition, 9 (90%) or 5 (50%) vaccine or placebo-recipients developed joint abnormalities, respectively (P = 0.0573). Therefore, vaccination with the ospA(-)/ospB(-) spirochete provided significant protection against Lyme disease. PMID: 25972405 [PubMed - as supplied by publisher] (Source: Clinical and Vaccine Immunology)


Tuesday 12 May 2015

Molecular Dissection of a Borrelia burgdorferi In Vivo Essential Purine Transport System [Molecular Pathogenesis]

The Lyme disease spirochete Borrelia burgdorferi is dependent on purine salvage from the host environment for survival. The genes bbb22 and bbb23 encode purine permeases that are essential for B. burgdorferi mouse infectivity. We now demonstrate the unique contributions of each of these genes to purine transport and murine infection. The affinities of spirochetes carrying bbb22 alone for hypoxanthine and adenine were similar to those of spirochetes carrying both genes. Spirochetes carrying bbb22 alone were able to achieve wild-type levels of adenine saturation but not hypoxanthine saturation, suggesting that maximal hypoxanthine uptake requires the presence of bbb23. Moreover, the purine transport activity conferred by bbb22 was dependent on an additional distal transcriptional start site ...


Monday 11 May 2015

Long-term study on ticks reveals shifting migration patterns, disease risks

Over nearly 15 years spent studying ticks, a new study has found southern Indiana to be an oasis free from Lyme disease, the condition most associated with ticks -- the second most common parasitic disease vector on Earth. This low-risk environment is changing, however, both in Indiana and in other regions of the U.S., the study suggests. (Source: ScienceDaily Headlines)

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Monday 11 May 2015

Comprehensive surveillance of the antibody response to Borrelia burgdorferi s.l. in small ruminants in China.

This study presents a comprehensive investigation of the serological distribution of B. burgdorferi s.l. in small ruminants in China. PMID: 26094509 [PubMed - as supplied by publisher] (Source: Annals of Agricultural and Environmental Medicine : AAEM)


Monday 11 May 2015

Polysynovitis in a horse due to [i]Borrelia burgdorferi[/i] sensu lato infection - Case study.

Authors: Passamonti F, Veronesi F, Cappelli K, Capomaccio S, Reginato A, Miglio A, Vardi DM, Stefanetti V, Coletti M, Bazzica C, Pepe M Abstract Lyme borreliosis (LB) is a multi-systemic tick-borne disease affecting both humans and animals, including horses, and is caused by a group of interrelated spirochetes classified within the Borrelia burgdorferi sensu lato (s.l.) complex. Despite the high reported seroprevalence in the European equine population for B. burgdorferi s.l., to-date no documented clinical cases have been described. A 6-year-old Paint gelding was referred with a history of three weeks of fever, intermittent lameness and digital flexor tendon sheath effusion of the right hind limb. Based on a strict diagnostic protocol, which included serological tests for infectio...


Saturday 9 May 2015

Toxic Turf? Movement Grows Against Synthetic Turf

The following story was reported by the New England Center for Investigative Reporting, an independent, nonprofit news center based at Boston University and WGBH News, and published here in collaboration with The Huffington Post. NECIR trains the next generation of journalists in investigative reporting with summer high school workshops in Boston. Click here to learn more and apply today. Artificial turf fields, cushioned with recycled crushed tires and increasingly in demand for US athletic complexes, are getting some serious pushback. In Swampscott last week, town meeting members approved plans to install a new synthetic field with silica sand, a more expensive product touted as a nontoxic alternative to the small rubber pellets known as crumb rubber ubiquitous on thousands of syntheti...


Friday 8 May 2015

Babesia spp. and other pathogens in ticks recovered from domestic dogs in Denmark

Conclusions: Our data are in support of endemic occurrence of potentially zoonotic Babesia in Denmark and confirms I. ricinus as a vector of multiple pathogens of public health concern. (Source: Parasites and Vectors)

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Monday 4 May 2015

Global Warming May Spread Lyme Disease

Scientists tackle the difficult problem of how climate change aids the spread of the tick-borne disease -- Read more on ScientificAmerican.com (Source: Scientific American - Official RSS Feed)


Sunday 3 May 2015

Warmer Weather Increases Risk for Lyme Disease, Cautions Best Friends Animal Hospital

(Source: Medical News (via PRIMEZONE))


Saturday 2 May 2015

A serological survey on Borrelia burgdorferi infection among companion dogs in Ahvaz district, southwestern Iran

Abstract Canine Lyme borreliosis is one of the most common tick-transmitted diseases in the world. The infection is caused by spirochetal bacteria from the genus Borrelia burgdorferi. The principal vectors are various species of slow-feeding hard ticks of the Ixodes complex. Dogs are the most infected animals among the pets. The status of infection due to Borrelia in dogs remains unknown in many areas of Iran. Few studies have been reported on the distribution of this disease in the Iran dog’s population, so the aim of this survey was to evaluate the seroprevalence of Borrelia infection in companion dogs in Ahvaz district (southwestern Iran), from October 2011 to August 2013. In the present survey, a total of 168 companion dogs with different ages were examined for serum antibod...


Friday 1 May 2015

New-onset panic, depression with suicidal thoughts, and somatic symptoms in a patient with a history of lyme disease.

We present a case of a 37-year-old man with no known psychiatric history who developed panic attacks, severe depressive symptoms and suicidal ideation, and neuromuscular complaints including back spasms, joint pain, myalgias, and neuropathic pain. These symptoms began 2 years after being successfully treated for a positive Lyme test after receiving a tick bite. During inpatient psychiatric hospitalization his psychiatric and physical symptoms did not improve with antidepressant and anxiolytic treatments. The patient's panic attacks resolved after he was discharged and then, months later, treated with long-term antibiotics for suspected "chronic Lyme Disease" (CLD) despite having negative Lyme titers. He however continued to have subsyndromal depressive symptoms and chronic physical symptom...


Friday 1 May 2015

Announcements: Lyme Disease Awareness Month — May 2015

(Source: CDC Morbidity and Mortality Weekly Report)


Friday 1 May 2015

Borrelia burgdorferi sensu lato infection pressure shapes innate immune gene evolution in natural rodent populations across Europe.

Authors: Tschirren B Abstract Although parasite-mediated selection is assumed to be the main driver of immune gene evolution, empirical evidence that parasites induce allele frequency changes at host immune genes in time and/or space remains scarce. Here, I show that the frequency of a protective gene variant of the innate immune receptor Toll-like receptor 2 in natural bank vole (Myodes glareolus) populations is positively associated with the strength of Borrelia burgdorferi sensu lato infection risk across the European continent. Thereby, this study provides rare evidence for the role of spatially variable infection pressures in moulding the vertebrate immune system. PMID: 26018834 [PubMed - in process] (Source: Biology Letters)


Wednesday 29 April 2015

Lyme neuroborreliosis in a patient treated with TNF-alpha inhibitor

Abstract A 57-year-old woman, receiving TNF-alpha inhibitor adalimumab for psoriasis, presented with early Lyme neuroborreliosis (Bannwarth’s syndrome). Discontinuation of adalimumab and 14-day therapy with ceftriaxone resulted in a smooth course and favorable outcome of Lyme borreliosis. This is the first report on Lyme neuroborreliosis in a patient treated with TNF-alpha inhibitor. (Source: Infection)

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Tuesday 28 April 2015

Lyme disease bacterium does not affect attraction to rodent odour in the tick vector

Conclusion: Our study suggests that the tick, and not the pathogen, controls the early stages of host choice behaviour. (Source: Parasites and Vectors)


Tuesday 28 April 2015

Hypercholesterolemia in Borrelia infection [Microbiology]

The Lyme disease (Borrelia burgdorferi) and relapsing-fever (Borrelia hispanica) agents have distinct infection courses, but both require cholesterol for growth. They acquire cholesterol from the environment and process it to form cholesterol glycolipids that are incorporated onto their membranes. To determine whether higher levels of serum cholesterol could enhance the... (Source: Proceedings of the National Academy of Sciences)


Monday 27 April 2015

Time to move Lyme Disease Awareness Month to April?

(Cary Institute of Ecosystem Studies) The month of May brings many things, among them Mother's Day, tulips, and Lyme Disease Awareness campaigns. But according to Dr. Richard S. Ostfeld, a disease ecologist at the Cary Institute of Ecosystem Studies in Millbrook, N.Y., if we want to get a leg up on tick-borne illness we need to become vigilant earlier in the season. (Source: EurekAlert! - Medicine and Health)

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Monday 27 April 2015

Interaction of spirochetes with the host fibrinolytic system and potential roles in pathogenesis.

Authors: Vieira ML, Nascimento AL Abstract The pathogenic spirochetes Borrelia burgdorferi, B. hermsii, B. recurrentis, Treponema denticola and Leptospira spp. are the etiologic agents of Lyme disease, relapsing fever, periodontitis and leptospirosis, respectively. Lyme borreliosis is a multi-systemic disorder and the most prevalent tick-borne disease in the northern hemisphere. Tick-borne relapsing fever is persistent in endemic areas worldwide, representing a significant burden in some African regions. Periodontal disease, a chronic inflammatory disorder that often leads to tooth loss, is caused by several potential pathogens found in the oral cavity including T. denticola. Leptospirosis is considered the most widespread zoonosis, and the predominant human disease in tropical, un...


Thursday 23 April 2015

The Lyme law.

Authors: Zubek E PMID: 25897168 [PubMed - in process] (Source: Canadian Medical Association Journal)


Thursday 23 April 2015

Big Tick Project to track rising threat of Lyme disease

Vets across the UK are set to take part in the Big Tick Project, the largest nationwide collection of ticks from dogs in a bid to help scientists, led by Professor Richard Wall at the University of Bristol, track what is feared to be a growing threat to people and their dogs from tick-borne zoonotic diseases such as Lyme disease (Borrelia). (Source: University of Bristol news)


Thursday 23 April 2015

Dog owners unaware their pets can transmit Lyme disease to them say vets

Vets are urging pet owners to check their animals for the pests, as a poll found half did not realise ticks can transmit deadly diseases to humans. The move is part of The Big Tick Project. (Source: the Mail online | Health)


Wednesday 22 April 2015

Popliteal Cyst With Positive Antinuclear Antibodies as the Presentation of Lyme Disease

No abstract available (Source: The Pediatric Infectious Disease Journal)

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Saturday 18 April 2015

Comparative genetic diversity of Lyme disease bacteria in Northern Californian ticks and their vertebrate hosts

Publication date: Available online 3 April 2015 Source:Ticks and Tick-borne Diseases Author(s): Andrea Swei , Verna C. Bowie , Rauri C.K. Bowie Vector-borne pathogens are transmitted between vertebrate hosts and arthropod vectors, two immensely different environments for the pathogen. There is further differentiation among vertebrate hosts that often have complex, species-specific immunological responses to the pathogen. All this presents a heterogeneous environmental and immunological landscape with possible consequences on the population genetic structure of the pathogen. We evaluated the differential genetic diversity of the Lyme disease pathogen, Borrelia burgdorferi, in its vector, the western black-legged tick (Ixodes pacificus), and in its mammal host community using the 5S–23S ...


Saturday 18 April 2015

New Borrelia species detected in ixodid ticks in Oromia, Ethiopia

Publication date: Available online 3 April 2015 Source:Ticks and Tick-borne Diseases Author(s): Bersissa Kumsa , Cristina Socolovschi , Didier Raoult , Philippe Parola Little is known about Borrelia species transmitted by hard ticks in Ethiopia. The present study was conducted from November 2011 through March 2014 to address the occurrence and molecular identity of these bacteria in ixodid ticks infesting domestic animals in Oromia, Ethiopia. A total of 767 ixodid ticks collected from domestic animals were screened for Borrelia DNA by quantitative (q) real-time PCR followed by standard PCR and sequencing to identify the species. Overall, 3.8% (29/767) of the tested ticks were positive for Borrelia DNA, including 8/119 (6.7%) Amblyomma cohaerens, 1/42 (2.4%) Am. gemma, 3/53 (5.7%) Am. var...


Saturday 18 April 2015

U.S. public's experience with ticks and tick-borne diseases: Results from national HealthStyles surveys

The objective of this study was to gain a more complete understanding of the U.S. public's experience with TBDs using data from annual, nationally representative HealthStyles surveys. There were 4728 respondents in 2009, 4050 in 2011, and 3503 in 2012. Twenty-one percent of respondents reported that a household member found a tick on his or her body during the previous year; of these, 10.1% reported consultation with a health care provider as a result. Overall, 63.7% of respondents reported that Lyme disease (LD) occurs in the area where they live, including 49.4% of respondents from the West South Central and 51.1% from the Mountain regions where LD does not occur. Conversely, in the New England and Mid-Atlantic regions where LD, anaplasmosis, and babesiosis are common, 13.9% and 20.8% of...


Saturday 18 April 2015

Vector potential and population dynamics for Amblyomma inornatum

Publication date: Available online 14 April 2015 Source:Ticks and Tick-borne Diseases Author(s): Jennifer S. Medlin , James I. Cohen , David L. Beck We studied the natural life cycle of Amblyomma inornatum and its vector potential in South Texas. This tick is distributed throughout South Texas and most of Central America. A. inornatum represented 1.91% of the ticks collected by carbon dioxide traps during a study of free-living ticks in the Tamaulipan Biotic Province in South Texas. The life cycle of A. inornatum in South Texas showed a clear seasonal pattern consistent with one generation per year. Nymphs emerged in the spring with a peak in February through May. Adults emerged in the summer with a peak in July through September. Detection of A. inornatum larvae was negatively correlate...


Thursday 16 April 2015

Harsh Northeast Winter No Hindrance To Hungry Ticks

http://media.boston.cbslocal.com/CBSBOS_1604201522190500000AA.mp4 ALBANY, N.Y. (AP) — Think you’re safe from ticks because the harsh winter froze them or because you haven’t been trekking through the woods? Think again. Researchers focused on ticks and the debilitating diseases they spread say the heavy snow that blanketed the Northeast this winter was like a cozy quilt for baby blacklegged ticks that are now questing for blood as the weather warms up. And a researcher at New York’s Binghamton University said Lyme disease-infected ticks aren’t just in forests and fields. “We’re finding plenty of infected ticks in built environments, places like city parks, playgrounds, work campuses, college campuses,” said Ralph Garruto, head of the sc...


Thursday 16 April 2015

Increasing evidence points to inflammation as source of nervous system manifestations of Lyme disease

(Elsevier Health Sciences) About 15 percent of patients with Lyme disease develop peripheral and central nervous system involvement, often accompanied by debilitating and painful symptoms. New research indicates that inflammation plays a causal role in the array of neurologic changes associated with Lyme disease, according to a study published in the American Journal of Pathology. The investigators at the Tulane National Primate Research Center and Louisiana State University Health Sciences Center also showed that the anti-inflammatory drug dexamethasone prevents many of these reactions. (Source: EurekAlert! - Infectious and Emerging Diseases)


Thursday 16 April 2015

Inflammation in the Pathogenesis of Lyme Neuroborreliosis

Lyme neuroborreliosis, caused by the spirochete Borrelia burgdorferi, affects both peripheral and central nervous systems. We assessed a causal role for inflammation in Lyme neuroborreliosis pathogenesis by evaluating the induced inflammatory changes in the central nervous system, spinal nerves, and dorsal root ganglia (DRG) of rhesus macaques that were inoculated intrathecally with live B. burgdorferi and either treated with dexamethasone or meloxicam (anti-inflammatory drugs) or left untreated. (Source: American Journal of Pathology)

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Thursday 16 April 2015

Borrelia miyamotoi: a widespread tick-borne relapsing fever spirochete.

Authors: Wagemakers A, Staarink PJ, Sprong H, Hovius JW Abstract Borrelia miyamotoi is a relapsing fever spirochete that has only recently been identified as a human pathogen. Borrelia miyamotoi is genetically and ecologically distinct from Borrelia burgdorferi sensu lato, while both are present in Ixodes ticks. Over 50 patients with an acute febrile illness have been described with a B. miyamotoi infection, and two infected immunocompromised patients developed a meningoencephalitis. Seroprevalence studies indicate exposure in the general population and in specific risk groups, such as patients initially suspected of having human granulocytic anaplasmosis. Here, we review the available literature on B. miyamotoi, describing its presence in ticks, reservoir hosts, and humans, and di...


Thursday 16 April 2015

Lyme disease presenting as multiple ischaemic strokes.

Authors: Li S, Vytopil M, Hreib K, Craven DE Abstract A 46-year-old man presented with recurrent left hemiparesis and headache. MRI of brain showed an acute right pontine and subacute right thalamic infarcts and MR angiogram showed multiple intracranial arterial stenoses, suggesting cerebral vasculopathy. There was a cerebrospinal fluid lymphocytic pleocytosis with Borrelia burgdorferi antibodies. Central nervous system Lyme disease occasionally presents with ischaemic strokes; this case is unusual in showing vasculopathy on brain imaging, supporting meningovasculitis as the likely mechanism. PMID: 25882056 [PubMed - as supplied by publisher] (Source: Practical Neurology)


Thursday 16 April 2015

Borrelia burgdorferi Not Confirmed in Human-Biting Amblyomma americanum Ticks from the Southeastern United States [Bacteriology]

The predominant human-biting tick throughout the southeastern United States is Amblyomma americanum. Its ability to transmit pathogens causing Lyme disease-like illnesses is a subject of ongoing controversy. Results of previous testing by the Department of Defense Human Tick Test Kit Program and other laboratories indicated that it is highly unlikely that A. americanum transmits any pathogen that causes Lyme disease. In contrast, a recent publication by Clark and colleagues (K. L. Clark, B. Leydet, and S. Hartman, Int. J. Med. Sci. 10:915–931, 2013) reported detection of Lyme group Borrelia in A. americanum using a nested-flagellin-gene PCR. We evaluated this assay by using it and other assays to test 1,097 A. americanum ticks collected from humans. Using the Clark assay, in most sam...




Wednesday 15 April 2015

Motor Rotation Is Essential for the Formation of the Periplasmic Flagellar Ribbon, Cellular Morphology, and Borrelia burgdorferi Persistence within Ixodes scapularis Tick and Murine Hosts [Molecular Pathogenesis]

Borrelia burgdorferi must migrate within and between its arthropod and mammalian hosts in order to complete its natural enzootic cycle. During tick feeding, the spirochete transmits from the tick to the host dermis, eventually colonizing and persisting within multiple, distant tissues. This dissemination modality suggests that flagellar motor rotation and, by extension, motility are crucial for infection. We recently reported that a nonmotile flaB mutant that lacks periplasmic flagella is rod shaped and unable to infect mice by needle or tick bite. However, those studies could not differentiate whether motor rotation or merely the possession of the periplasmic flagella was crucial for cellular morphology and host persistence. Here, we constructed and characterized a motB mutant that is non...

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Wednesday 15 April 2015

Anti-neural antibody response in patients with post-treatment Lyme disease symptoms versus those with myalgic encephalomyelitis/chronic fatigue syndrome

Publication date: Available online 10 April 2015 Source:Brain, Behavior, and Immunity Author(s): Mary Ajamian , Michael Cooperstock , Gary P. Wormser , Suzanne D. Vernon , Armin Alaedini (Source: Brain, Behavior, and Immunity)


Monday 13 April 2015

First record of autochthonous canine ehrlichiosis caused by Ehrlichia canis in Romania

This report supports the geographical expansion of canine ehrlichiosis caused by E canis in nonendemic regions of Europe. (Source: Veterinary Clinical Pathology)


Monday 13 April 2015

Lyme neuroborreliosis: a treatable cause of acute ocular motor disturbances in children.

CONCLUSIONS: LNB can present as acute ocular motor disorders in conjunction with fatigue and other clinical manifestations. In endemic areas, children with unexplained, acquired ocular motor abnormalities should be evaluated for LNB, a treatable medical condition. PMID: 25868792 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)


Monday 13 April 2015

Inflammation in the Pathogenesis of Lyme Neuroborreliosis.

Authors: Ramesh G, Didier PJ, England JD, Santana-Gould L, Doyle-Meyers LA, Martin DS, Jacobs MB, Philipp MT Abstract Lyme neuroborreliosis, caused by the spirochete Borrelia burgdorferi, affects both peripheral and central nervous systems. We assessed a causal role for inflammation in Lyme neuroborreliosis pathogenesis by evaluating the induced inflammatory changes in the central nervous system, spinal nerves, and dorsal root ganglia (DRG) of rhesus macaques that were inoculated intrathecally with live B. burgdorferi and either treated with dexamethasone or meloxicam (anti-inflammatory drugs) or left untreated. ELISA of cerebrospinal fluid showed significantly elevated levels of IL-6, IL-8, chemokine ligand 2, and CXCL13 and pleocytosis in all infected animals, except dexamethason...


Monday 13 April 2015

Monday's Housecall

THIS WEEK'S TOP STORIES Vegetarian diet: How to get the best nutrition Going vegetarian means excluding certain foods. But you can still get the nutrients you need from other sources. Use this helpful guide. Lyme disease Grassy and heavily wooded areas can be home to ticks, which can carry Lyme disease. Get tips on prevention [...] (Source: News from Mayo Clinic)


Friday 10 April 2015

Doctors warn about tick-borne Powassan virus

It's not as well known as Lyme disease, but the Powassan virus is also spread by ticks, and experts say it can be even more severe. WCBS's Tracee Carrasco reports. (Source: Health News: CBSNews.com)


Friday 10 April 2015

Painful blister‐free HSV‐type 1 reactivation on the site of acute Lyme borreliosis

(Source: Journal of the European Academy of Dermatology and Venereology)


Thursday 9 April 2015

Painful blister ‐free HSV‐type 1 reactivation on the site of acute Lyme borreliosis

(Source: Journal of the European Academy of Dermatology and Venereology)

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Thursday 9 April 2015

Anti-Neural Antibody Response in Patients with Post-Treatment Lyme Disease Symptoms versus Those with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Authors: Ajamian M, Cooperstock M, Wormser GP, Vernon SD, Alaedini A PMID: 25866194 [PubMed - as supplied by publisher] (Source: Brain, Behavior, and Immunity)


Wednesday 8 April 2015

Increased intracranial pressure as a presentation of Lyme disease in children: A case series. (P1.310)

Conclusion: The presence of fever, rash, cranial nerve enhancement on MRI, and lymphocytosis on CSF analysis is helpful in distinguishing between idiopathic PTC and PTC secondary to Lyme. Absence of rash does not exclude Lyme and remains a diagnostic consideration in Lyme endemic areas. Disclosure: Dr. Obeid has nothing to disclose. Dr. Ramgopal has nothing to disclose. Dr. Cleves has nothing to disclose. Dr. Nowak has nothing to disclose. (Source: Neurology)


Wednesday 8 April 2015

Amyotrophic Lateral Sclerosis (ALS) with Laboratory Abnormalities of Unknown Significance (LAUS) --Where Does It Begin and Where Does It End? (P4.144)

CONCLUSIONS: Further detailed analysis of progression rate by site of onset, sex, age, treatment will require assimilation of clinic-based datasets of properly analyzed ALS-LAUS patients from multiple clinic sites. The appropriate role of IVIg in ALS-LAUS patients requires further study following explication of the natural history of these patients compared with non-ALS-LAUS patients. The determination as to whether auto-antibodies to additional antigens may play a role in the progression rate of ALS-LAUS compared with sporadic ALS needs to be systematically studied. Study Supported by: Carolinas ALS Research FundDisclosure: Dr. Brooks has received personal compensation for activities with Biogen Idec, Avanir Pharmaceuticals, Acorda Therapeutics, Cytokinetics, Synapse, and the National Ins...


Wednesday 8 April 2015

Neuropathic Pain Treatments and Quality of Life Results in Leprosy Patients (P6.313)

CONCLUSION: This study highlights the superiority of Group 1 compared to Group 2 when analyzing the results. Although Group 1 was statistically superior to Group 2, the Limitations by Emotional Aspects criteria showed no statistical difference in both. One might speculate as hypothesis for this finding, aspects that go beyond pharmacotherapy, such as the impact of stigma related to the presence of cutaneous manifestations.Disclosure: Dr. Dornas has nothing to disclose. Dr. Nascimento has nothing to disclose. Dr. Pupe has nothing to disclose. Dr. Araujo has nothing to disclose. Dr. Davidovich has nothing to disclose. Dr. Vianna has nothing to disclose. Dr. Coutinho has nothing to disclose. Dr. Bittar has nothing to disclose. (Source: Neurology)


Wednesday 8 April 2015

Subarachnoid hemorrhage: a rare complication of pyogenic bacterial meningitis (P6.312)

Conclusion: SAH in meningitis could be explained by vasculitis or undetected ruptured mycotic aneurysm induced by acute inflammation from meningitis. In conclusion, with supportive clinical features, we should consider meningitis as a differential diagnosis in patient with non-traumatic and non-aneurysmal SAH as these two conditions have totally different treatment.Disclosure: Dr. Julayanont has nothing to disclose. Dr. Wang has nothing to disclose. Dr. Laengvejkal has nothing to disclose. Dr. Tantikittichaikul has nothing to disclose. Dr. DeToledo has nothing to disclose. (Source: Neurology)


Wednesday 8 April 2015

Treatment of North American Lyme Neuroborrelliosis with Oral Doxycycline and Intravenous Ceftriaxone: A comparative case series. (P6.309)

CONCLUSIONS: Oral Doxycycline may be a comparable alternative to treating North American Lyme Neuroborrellosls. Further systematic studies are needed.Disclosure: Dr. Alario has nothing to disclose. Dr. Baldwin has nothing to disclose. (Source: Neurology)


Wednesday 8 April 2015

Clinical, Laboratory Findings and Complications of Scrub Typhus- Meningoencephalitis: Case Series (P6.311)

CONCLUSION: Scrub typhus is often underdiagnosed in India due to non-specific clinical features and lack of diagnostic facilities. Meningoencephalitis with altered LFT should raise suspicion for scrub typhus especially after ruling out TBM. Eschar may give a clue to diagnosis but it is present in only 20-30[percnt] and usually goes unnoticed in dark skinned people. It can mimic TB meningitis and starting ATT can worsen liver function. Early diagnosis and treatment with tetracycline is necessary to prevent life threatening complications.Disclosure: Dr. Eswaradass has nothing to disclose. Dr. Eswaradass has nothing to disclose. (Source: Neurology)


Wednesday 8 April 2015

Fulminant necrotizing encephalitis associated with malignant cerebral edema and transtentorial herniation in the setting of acute seasonal influenza pneumonia. (P6.315)

We describe the most severe neurological complication associated with seasonal influenza: necrotizing encephalitis with malignant cerebral edema. We review the pathogenesis surrounding this neurological manifestation.We suggest a monitoring approach in this particular setting. INTRODUCTION: Influenza-related neurological complications are rare and have variable presentation. Influenza-related necrotizing encephalitis with associated malignant cerebral edema represents the most severe manifestation of the spectrum of influenza-related neurological complications, and carries very high mortality. METHOD: This is a case report with review of previously described cases (Pubmed search). RESULTS: A previously healthy 43 year old woman presented with upper respiratory symptoms over 24-hourswas and...

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Wednesday 8 April 2015

Severe ascending muscle spasms associated with diffuse perineural Tarlov cysts. (P3.316)

CONCLUSION: Diffuse Tarlov cysts may cause episodic severe widespread, ascending muscle spasms.Disclosure: Dr. Safarpour has nothing to disclose. Dr. Mulukutla has nothing to disclose. Dr. Khokhar has nothing to disclose. Dr. Jabbari has received research support from Allergan Inc., Merz Pharma, and Ipsen. (Source: Neurology)

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Wednesday 8 April 2015

Serum and CSF Cytokines in Patients with Active CNS Lyme Disease, other Inflammatory CNS Diseases, Encephalopathy Following Treated Lyme Disease, other Encephalopathies, and Normal Controls (S37.007)

Conclusions: Patients with neurobehavioral symptoms following treatment for Lyme disease do not show any evidence of nervous system infection or inflammation. Elevations in serum IL-7 and IL-17 in these patients may reflect T-cell dysregulation. Interestingly, such elevations were seen in symptomatic patients regardless of prior Lyme disease exposure. These results warrant further investigation, as IL-7 may represent a useful biomarker, and could lead to the identification of novel therapeutic targets.Disclosure: Dr. Halperin has received personal compensation in an editorial capacity for The Neurologist. Dr. Halperin holds stock and/or stock options in Abbott Labs, Bristol Myers Squib, Johnson & Johnson. Dr. Pacheco-Quinto has nothing to disclose. Dr. Herdt has nothing to disclose. Dr...


Wednesday 8 April 2015

Successful Treatment of Eastern Equine Encephalitis with Early, Empiric Initiation of Intravenous Immunoglobulin: A Case Report (P6.306)

CONCLUSIONS: We report the successful treatment of suspected EEE with early, empiric use of IVIG. Given the significant mortality and morbidity associated with untreated EEE, early use of IVIG prior to serologic diagnosis may be beneficial when clinical suspicion is high.Disclosure: Dr. Erkkinen has nothing to disclose. Dr. Srikanth has nothing to disclose. Dr. Lyons has received personal compensation in an editorial capacity for Current Infectious Disease Reports. Dr. Vaitkevicius has nothing to disclose. (Source: Neurology)


Wednesday 8 April 2015

Utility of Broad-Range PCR Testing in Suspected CNS Infections (P6.317)

CONCLUSIONS: In our series the most common reason for a positive broad-range PCR result was contamination. Unlike endocarditis, in suspected CNS infections broad-range PCR was not useful, probably because the etiologies are often viruses (which are not amenable to broad-range PCR) or non-infectious. CSF might not be the ideal specimen for intra parenchymal processes. Further research is needed to identify which syndromes and specimen source would be ideal for broad-range PCR in CNS infection.Disclosure: Dr. Koffman has nothing to disclose. Dr. Bernatowicz has nothing to disclose. Dr. Shrestha has nothing to disclose. Dr. Bhimraj has nothing to disclose. (Source: Neurology)


Wednesday 8 April 2015

Risk Factors and Final Diagnoses of Patients first diagnosed as Infectious Acute Disseminated Encephalomyelitis (ADEM): A single-center study (P1.106)

CONCLUSIONS: A large minority [17[percnt]] of patients was ultimately diagnosed with other conditions than ADEM, which may change longterm prognoses for patients. Vaccination prior to ADEM diagnosis is rare.Disclosure: Dr. Koelman has nothing to disclose. Dr. Chitnis has received personal compensation for activities with Biogen Idec and Alexion. Dr. Chitnis has received research support from Merck Serono and Novartis. Dr. Mateen has nothing to disclose. (Source: Neurology)


Wednesday 8 April 2015

An unusual presentation of Neuro Lyme (P6.308)

CONCLUSIONS: Neuro-Lyme should be suspected with unexplained neurological symptoms and signs in endemic areas.Disclosure: Dr. Tom has nothing to disclose. Dr. Mohamed has nothing to disclose. Dr. Holloway has nothing to disclose. (Source: Neurology)


Wednesday 8 April 2015

First Reported Case of a Brain Abscess with Ustekinumab for Psoriatic Arthritis (P6.314)

CONCLUSIONS: This is the first reported case of a patient taking Ustekinumab that developed a brain abscess after a dental procedure. Considering the high prevalence of patients that are treated with immune-modulating medications for various medical conditions, and the higher risk of infections that they entail, it may be beneficial to recommend antibiotic prophylaxis for such patients when undergoing dental and minor surgical procedures.Disclosure: Dr. Rahman has nothing to disclose. Dr. Thomas has nothing to disclose. Dr. Rahman has nothing to disclose. Dr. Javed has nothing to disclose. Dr. Jovan has nothing to disclose. (Source: Neurology)


Wednesday 8 April 2015

Risk Factors and Final Diagnoses of Patients first diagnosed as Infectious Acute Disseminated Encephalomyelitis (ADEM): A single-center study (I4-3B)

CONCLUSIONS: A large minority [17[percnt]] of patients was ultimately diagnosed with other conditions than ADEM, which may change longterm prognoses for patients. Vaccination prior to ADEM diagnosis is rare.Disclosure: Dr. Koelman has nothing to disclose. Dr. Chitnis has received personal compensation for activities with Biogen Idec and Alexion. Dr. Chitnis has received research support from Merck Serono and Novartis. Dr. Mateen has nothing to disclose. (Source: Neurology)


Wednesday 8 April 2015

A unique case of leptomeningitis associated with rheumatoid-like arthritis and naegleria fowleri. (P6.316)

Conclusions NF in brain tissue coincided with new onset rheumatoid arthritis and leptomeningitis. These findings have not been previously documented.Disclosure: Dr. Rodriguez Alvarez has nothing to disclose. Dr. Mirchandani has nothing to disclose. Dr. Khan has nothing to disclose. Dr. Medin has nothing to disclose. Dr. Seidman has nothing to disclose. Dr. Madison-Antenucci has nothing to disclose. Dr. Espina has nothing to disclose. Dr. Teal has nothing to disclose. Dr. Mergen has nothing to disclose. (Source: Neurology)


Wednesday 8 April 2015

Borrelia Hispanica: an Emerging Infectious Agent Causing Neuroborreliosis (P6.310)

CONCLUSIONS: BH infection uses as a vector the tick Ornithodoros erraticus and its clinical expression is relapsing fever. BH is located mainly in Morocco and recently its genome has been sequenced. After an extensive review of the literature (Pubmed) we did not find any cases of CNS involvement by BH. The case presented above was characterized by the virulent CNS involvement by BH, the neuroimaging findings and therapeutic management, which may help to identify similar cases. If new cases confirmed the settlement of this zoonosis in Spain, an epidemiological study and control in mammals would be required.Disclosure: Dr. cerdan has nothing to disclose. Dr. Sánchez Martínez has nothing to disclose. Dr. Palazon Cabanes has nothing to disclose. Dr. Carreon Guarnizo has nothing t...

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Wednesday 8 April 2015

Neuroborreliosis Parkinsonism and Rapid Eye Movement Sleep Behavior Disorder (P7.292)

CONCLUSIONS: This is the first case report to our knowledge of a patient developing RBD in addition to post-infectious parkinsonism due to neurodegeneration of the midbrain and basal ganglia from neuroborreliosis.Disclosure: Dr. Werbaneth has nothing to disclose. Dr. Zuzuarregui has nothing to disclose. Dr. Hohler has nothing to disclose. (Source: Neurology)


Monday 6 April 2015

An Association Between Morgellons Disease and Lyme Disease?An Association Between Morgellons Disease and Lyme Disease?

While Morgellons disease has sometimes been considered a delusional syndrome, this microscopic and molecular study suggests that it is an infectious illness associated with Borrelia spirochetes. BMC Dermatology (Source: Medscape Dermatology Headlines)


Monday 6 April 2015

A Gardener with a Fever for 2 Weeks

Dr. Margaret Greenwood-Erickson: Today's case is that of a 58-year-old man who was sent to the emergency department (ED) by his primary care physician (PCP) for evaluation of fevers and lightheadedness. He had been well until 2 weeks before ED presentation when he developed nonproductive cough, malaise, weakness, and daily subjective fevers. He was seen by his PCP 2 days before presentation and started on doxycycline for treatment of presumptive Lyme disease. Laboratory tests, including a Lyme titer, were sent. (Source: The Journal of Emergency Medicine)

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Friday 3 April 2015

Preventive Behaviors and Knowledge of Tick-Borne Illnesses: Results of a Survey From an Endemic Area

Conclusions: Public health interventions focusing on accurately communicating risk, improving knowledge both of LD symptoms and of ticks that carry the disease, as well as teaching preventive behaviors may help reduce tick-borne illness rates. (Source: Journal of Public Health Management and Practice)


Friday 3 April 2015

Efficacy of a fixed combination of permethrin 54.5% and fipronil 6.1% (Effitix®) in dogs experimentally infested with Ixodes ricinus

Conclusions: The study has shown under laboratory conditions, that Effitix® is a safe and an effective combination to treat and protect dogs from Ixodes ricinus up to 37 days after administration. The high immediate efficacy of 98% evaluated at 48 hours post-treatment was particularly interesting, meaning that Effitix has a curative effect against ticks (Ixodes ricinus) and provides a rapid control of existing Ixodes ricinus infestation on a dog at the time of treatment. (Source: Parasites and Vectors)


Thursday 2 April 2015

'I thought I was dying,' Avril Lavigne says of Lyme disease

(Source: CNN.com - Health)

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Thursday 2 April 2015

Lyme disease: recent advances and perspectives

Tanja Petnicki-Ocwieja and Catherine Ayn Brissette (Source: Frontiers in cellular and infection microbiology)


Wednesday 1 April 2015

Avril Lavigne and Lyme Disease: Your Questions Answered

Singer Avril Lavigne revealed in the latest issue of People Magazine that she has been diagnosed with Lyme disease. (Source: ABC News: Health)


Wednesday 1 April 2015

Skin and arthropods: an effective interaction used by pathogens in vector-borne diseases

Abstract In the last years, the skin has been described as a major interface in arthropod borne diseases. Although it constitutes an efficient immune and physical barrier, pathogens have developed effective strategies to thwart the host. In this process, the arthropod plays a major role. For mosquitoes, the quick blood meal is made through an efficient inoculation process directly into the blood vessel. For the long lasting blood meal of hard ticks, the sophisticated biting pieces and the tick saliva provide potent tools to help pathogen transmission. Lyme borreliosis and leishmaniases have been particularly well investigated in this context. (Source: European Journal of Dermatology)


Wednesday 1 April 2015

Combination of Loop-Mediated Isothermal Amplification Assay and Nested PCR for Detection of Borrelia burgdorferi sensu lato in Human Serum Samples.

Authors: Zhang LL, Hou XX, Geng Z, Lou YL, Wan KL, Hao Q Abstract A set of universal loop-mediated isothermal amplification (LAMP) primers targeting the fla gene was designed to detect Borrelia burgdorferi sensu lato (B. burgdorferi s.l.) in human samples. The sensitivity of LAMP was 20 copies/reaction, and the assay did not detect false positives among 11 other related bacteria. A positive LAMP result was obtained for 9 of the 24 confirmed cases and for 12 of 94 suspected cases. The positive rate of LAMP was the same as that of nested PCR. The LAMP is a useful diagnostic method that can be developed for rapid detection of B. burgdorferi s.l. in human sera. Combination of the LAMP and nested PCR was more sensitive for detecting B. burgdorferi s.l. in human serum samples. PMID...


Wednesday 1 April 2015

Seroprevalence of lyme borreliosis in Scottish blood donors

(Source: Transfusion Medicine)

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Wednesday 1 April 2015

Host cell heparan sulfate glycosaminoglycans are ligands for OspF‐related proteins of the Lyme disease spirochete

Summary Borrelia burgdorferi, the agent of Lyme disease, spreads from the site of the tick bite to tissues such as heart, joints and the nervous system. Host glycosaminoglycans (GAGs), highly modified repeating disaccharides that are present on cell surfaces and in extracellular matrix, are common targets of microbial pathogens during tissue colonization. While several dermatan sulfate‐binding B. burgdorferi adhesins have been identified, B. burgdorferi adhesins documented to promote spirochetal binding to heparan sulfate have not yet been identified. OspEF‐related proteins (Erps), a large family of plasmid‐encoded surface lipoproteins that are produced in the mammalian host, can be divided into the OspF‐related, OspEF leader peptide (Elp), and OspE‐related subfamilies. We show h...


Tuesday 31 March 2015

New insights into Lyme disease

Publication date: August 2015 Source:Redox Biology, Volume 5 Author(s): Brandon N. Peacock , Teshome B. Gherezghiher , Jennifer D. Hilario , Gottfried H. Kellermann Lyme borreliosis is transmitted through the bite of a tick that is infected by the bacterial spirochete Borrelia burgdorferi. Clinical manifestation of the disease can lead to heart conditions, neurological disorders, and inflammatory disorders. Oxidative stress has been implicated in the pathogenesis of many human diseases. The aim of this study was to investigate the mechanisms of oxidative stress and intracellular communication in Lyme borreliosis patients. Mitochondrial superoxide and cytosolic ionized calcium was measured in peripheral blood mononuclear cells (PBMCs) of Lyme borreliosis patients and healthy controls. Mit...


Sunday 29 March 2015

20 pupils violently ill after schoolgirl smoking addict, 12, passed round prescription nicotine spray

The dispenser was passed around a group of Year Seven and Eight pupils at Wolstanton High School, in Newcastle-under-Lyme (Source: Telegraph Health)


Sunday 29 March 2015

Identification of 24h Ixodes scapularis immunogenic tick saliva proteins

This study describes identification of 24h immunogenic I. scapularis tick saliva proteins, which could provide opportunities to develop strategies to stop tick feeding before transmission of the majority of pathogens. A 24h fed female I. scapularis phage display cDNA expression library was biopanned using rabbit antibodies to 24h fed I. scapularis female tick saliva proteins, subjected to next generation sequencing, de novo assembly, and bioinformatic analyses. A total of 182 contigs were assembled, of which ∼19% (35/182) are novel and did not show identity to any known proteins in GenBank. The remaining ∼81% (147/182) of contigs were provisionally identified based on matches in GenBank including ∼18% (27/147) that matched protein sequences previously annotated as hypothetical and pu...


Saturday 28 March 2015

Inflammatory mediator release from primary rhesus microglia in response to Borrelia burgdorferi results from the activation of several receptors and pathways

Conclusions: Several receptors and pathways, with both positive and negative effects, mediate inflammation of primary microglia in response to B. burgdorferi, resulting in a complex, tightly regulated immune network. (Source: Journal of Neuroinflammation)

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Friday 27 March 2015

NGS population genetics analyses reveal divergent evolution of a Lyme Borreliosis agent in Europe and Asia

Publication date: Available online 10 March 2015 Source:Ticks and Tick-borne Diseases Author(s): Fanny Gatzmann , Dirk Metzler , Stefan Krebs , Helmut Blum , Andreas Sing , Ai Takano , Hiroki Kawabata , Volker Fingerle , Gabriele Margos , Noémie S. Becker Borrelia bavariensis is a recently described agent of Lyme disease within the B. burgdorferi sensu lato species complex and exhibits a strong capacity for human pathogenicity. B. bavariensis strains are widely distributed in Eurasia spanning the distribution range of the tick vectors Ixodes persulcatus and I. ricinus. It has been suggested that B. bavariensis forms two populations, one of which arose through vector adaptation and geographic expansion. We have performed phylogenetic and population genetic analyses with next-generation s...


Friday 27 March 2015

Infection of Siberian chipmunks (Tamias sibiricus barberi) with Borrelia sp. reveals a low reservoir competence under experimental conditions

Publication date: Available online 21 March 2015 Source:Ticks and Tick-borne Diseases Author(s): Sarah Bonnet , Valérie Choumet , Sébastien Masseglia , Martine Cote , Elisabeth Ferquel , Thomas Lilin , Maud Marsot , Jean-Louis Chapuis , Gwenaël Vourc’h Reservoir competence is a key parameter in understanding the role of host species in the epidemiology of multi-host—especially vector-borne—pathogens. With this aim in view, we studied the reservoir competence of the Siberian chipmunk (Tamias sibiricus barberi) recently introduced into Europe, for the multi-host tick-borne bacteria, Borrelia burgdorferi sl, the agent of Lyme borreliosis. T. sibiricus were experimentally exposed to bites from Ixodes ricinus ticks infected with Borrelia burgdorferi sensu stricto and Borrelia afzelii...


Thursday 26 March 2015

Mother left with a paralysed face and in crippling pain after being bitten on the HIP by a tick while gardening

Claire Dean, 43, from Castle Douglas, Scotland, developed Lyme disease after being bitten by a tick in her garden. She suffered pain so bad she had to quit her job and is still receiving physiotherapy for her face. (Source: the Mail online | Health)


Tuesday 24 March 2015

Characterization of the β-barrel assembly machine accessory lipoproteins from Borrelia burgdorferi

Conclusions: Combined structural studies, functional assays, and co-immunoprecipitation experiments confirmed that BB0028 and BB0324 are the respective BamB and BamD orthologs in B. burgdorferi, and are important in membrane integrity and/or outer membrane protein localization. The borrelial BamB and BamD proteins both interact specifically and independently with BamA to form a tripartite BAM complex in B. burgdorferi. A working model has been developed to further analyze outer membrane biogenesis and outer membrane protein transport in this pathogenic spirochete. (Source: BMC Microbiology)


Monday 23 March 2015

Climate change 'might bring rise in UK mosquito-borne diseases'

Conclusion Overall, this review provides insights into how climate change might lead to the transmission of tropical diseases in what are currently temperate parts of the world, such as the UK. Predicting what may happen in the future can help countries make sure they are prepared for such an eventuality. This review was informed by a search for relevant literature, but may not have captured or included all relevant studies. Most of the studies were modelling studies, which are reliant on various assumptions that may or may not turn out to be correct. It's not possible to say with any certainty what will occur in the future. The authors also note that climate change is not the only factor affecting vector-borne diseases. Many other factors are equally important, such as socioeconomic de...


Monday 23 March 2015

Canine vector-borne infections in Mauritius

Conclusions: Infection with these pathogens had no significant effect on the packed cell volume (PCV), but high tick burdens were significantly associated with the presence of a tick-borne pathogen. This is the first study of its kind on the dog population in Mauritius and demonstrates the presence of previously undocumented canine vector-borne infections on the island. The relatively high proportion of infected dogs within the study should alert clinicians to the presence of canine vector-borne diseases on the island of Mauritius. (Source: Epidemiologic Perspectives and Innovations)


Monday 23 March 2015

Bacterial and protozoal agents of canine vector-borne diseases in the blood of domestic and stray dogs from southern Portugal

Conclusions: The molecular identification of CVBD agents in southern Portugal, some of them with zoonotic concern, reinforces the importance to alert the veterinary community, owners and public health authorities to prevent the risk of transmission of vector-borne pathogens among dogs and to other vertebrate hosts including humans. The prevalence of the selected pathogens was lower than that previously found in cats from the same region, probably because veterinarians and owners are more aware of them in the canine population and control measures are used more often. (Source: Epidemiologic Perspectives and Innovations)

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Monday 23 March 2015

[Review] Effect of climate change on vector-borne disease risk in the UK

During the early part of the 21st century, an unprecedented change in the status of vector-borne disease in Europe has occurred. Invasive mosquitoes have become widely established across Europe, with subsequent transmission and outbreaks of dengue and chikungunya virus. Malaria has re-emerged in Greece, and West Nile virus has emerged throughout parts of eastern Europe. Tick-borne diseases, such as Lyme disease, continue to increase, or, in the case of tick-borne encephalitis and Crimean-Congo haemorrhagic fever viruses, have changed their geographical distribution. (Source: The Lancet Infectious Diseases)


Saturday 21 March 2015

Lyme disease: A case report of a 17-year old male with fatal Lyme carditis

We describe a case of a 17-year-old adolescent who died unexpectedly after a 2-week viral-like syndrome. Postmortem examination was remarkable for diffuse pancarditis characterized by extensive infiltrates of lymphocytes and focal interstitial fibrosis. (Source: Cardiovascular Pathology)


Saturday 21 March 2015

Lyme disease: a case report of a 17-year-old male with fatal Lyme carditis

We describe a case of a 17-year-old adolescent who died unexpectedly after a 3-week viral-like syndrome. Postmortem examination was remarkable for diffuse pancarditis characterized by extensive infiltrates of lymphocytes and focal interstitial fibrosis. (Source: Cardiovascular Pathology)


Wednesday 18 March 2015

An investigation of binding ability of Ixodes persulcatus Schulze Salp15 with Lyme disease spirochetes.

Authors: Murase Y, Konnai S, Yamada S, Githaka N, Isezaki M, Ito T, Takano A, Ando S, Kawabata H, Murata S, Ohashi K Abstract Salp15, a 15-kDa tick salivary gland protein, has several suppressive modes of activity against host immunity and plays a critical role in the transmission of Lyme disease spirochetes in Ixodes scapularis and I. ricinus, major vectors of Lyme disease in North America and Western Europe. Salp15 adheres to Borrelia burgdorferi and specifically interacts with its outer surface protein C (OspC), protecting the spirochete from antibody-mediated cytotoxicity and facilitating infection in the mice. Recently, we identified two Salp15 homologues, IperSalp15-1 and IperSalp15-2, in I. persulcatus, a vector for Lyme disease in Japan. Here we describe the function of Ipe...


Tuesday 17 March 2015

Apparent Role for Borrelia burgdorferi LuxS during Mammalian Infection [Bacterial Infections]

The Lyme disease spirochete, Borrelia burgdorferi, controls protein expression patterns during its tick-mammal infection cycle. Earlier studies demonstrated that B. burgdorferi synthesizes 4,5-dihydroxy-2,3-pentanedione (autoinducer-2 [AI-2]) and responds to AI-2 by measurably changing production of several infection-associated proteins. luxS mutants, which are unable to produce AI-2, exhibit altered production of several proteins. B. burgdorferi cannot utilize the other product of LuxS, homocysteine, indicating that phenotypes of luxS mutants are not due to the absence of that molecule. Although a previous study found that a luxS mutant was capable of infecting mice, a critical caveat to those results is that bacterial loads were not quantified. To more precisely determine whether LuxS se...

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Monday 16 March 2015

Lyme: inflammation, oxidative stress, and mitochondrial dysfunction

Publication date: Available online 16 March 2015 Source:Redox Biology Author(s): Brandon N. Peacock , Teshome B. Gherezghiher , Jennifer D. Hilario , Gottfried H. Kellermann Lyme borreliosis is transmitted through the bite of a tick that is infected by the bacterial spirochete Borrelia burgdorferi. Clinical manifestation of the disease can lead to heart conditions, neurological disorders, and inflammatory disorders. Oxidative stress has been implicated in the pathogenesis of many human diseases. The aim of this study was to investigate the mechanisms of oxidative stress and intracellular communication in Lyme borreliosis patients. Mitochondrial superoxide and cytosolic ionized calcium was measured in peripheral blood mononuclear cells (PBMCs) of Lyme borreliosis patients and healthy cont...


Sunday 15 March 2015

Physician reported incidence of early and late Lyme borreliosis

Conclusions: This is the first reported nationwide physician survey on the incidence of tick bites and the whole range of manifestations of Lyme borreliosis, including persisting symptoms attributed to Lyme borreliosis. This is crucial for complete assessment of the public health impact of Lyme borreliosis. (Source: Parasites and Vectors)


Saturday 14 March 2015

Association of Toll-like Receptor 2 Arg753Gln and Toll-like Receptor 1 Ile602Ser Single-Nucleotide Polymorphisms with Leptospirosis in an Argentine Population.

In conclusion, the present data suggest that the TLR2 Arg753Gln and TLR1 Ile602Ser SNPs influence the risk of developing leptospirosis and its severity. PMID: 25784560 [PubMed - as supplied by publisher] (Source: Acta Tropica)


Friday 13 March 2015

RNA-Seq-based analysis of changes in Borrelia burgdorferi gene expression linked to pathogenicity

Our objectives aimed at the differentially expressed genes that contribute to Borrelia-specific disease diversity. The results indicated a total of 731 genes were differentially expressed between B. burgdorferi B31 and B. garinii SZ isolates, including those encoding lipoproteins and purine transport proteins. The findings also provide an empirical basis for studying the mechanism of action of specific genes as well as their potential usefulness for the diagnosis and management of Lyme disease. Image: Giemsa-stained Borrelia isolate. (Source: Parasites and Vectors)


Thursday 12 March 2015

Neuromyelitis optica phenotype associated with therapy-responsive acute peripheral neuropathy

A 51-year-old Hispanic woman with a history of Churg-Strauss syndrome (in remission for 20 years)–associated mesangial glomerulonephritis and end-stage renal disease with a recent renal transplant and previously cured cytomegalovirus (CMV) infection who was on a tapering dose of tacrolimus presented with sudden onset of lower extremity numbness. Symptoms progressed to complete paraplegia and sensory loss over 24 hours. The following day, ascending paresis extended to bilateral upper extremities, with high thoracic sensory level and complete blindness. Initial MRI revealed contrast enhancement of bilateral prechiasmatic optic nerve as well as T2 hyperintensities involving the central gray matter of the entire spinal cord with associated edema. CSF analysis documented neutrophilic pleo...

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Tuesday 10 March 2015

Evolution and population genomics of the Lyme borreliosis pathogen, Borrelia burgdorferi

Publication date: Available online 9 March 2015 Source:Trends in Genetics Author(s): Stephanie N. Seifert , Camilo E. Khatchikian , Wei Zhou , Dustin Brisson Population genomic studies have the potential to address many unresolved questions about microbial pathogens by facilitating the identification of genes underlying ecologically important traits, such as novel virulence factors and adaptations to humans or other host species. Additionally, this framework improves estimations of population demography and evolutionary history to accurately reconstruct recent epidemics and identify the molecular and environmental factors that resulted in the outbreak. The Lyme disease bacterium, Borrelia burgdorferi, exemplifies the power and promise of the application of population genomics to microbia...


Tuesday 10 March 2015

Treatment of Menière’s Disease

Opinion statement Diagnosis of Menière’s disease is made with a characteristic patient history, including discrete episodes of vertigo lasting 20 min or longer, accompanied by sensorineural hearing loss, which is typically low frequency at first, aural fullness, and tinnitus. Workup includes audiometry, a contrast enhanced MRI of the internal auditory canals, and exclusion of other diseases that can produce similar symptoms, like otosyphilis, autoimmune inner ear disease, perilymphatic fistula, superior semicircular canal syndrome, Lyme disease, multiple sclerosis, vestibular paroxysmia, and temporal bone tumors. A history of migraine should be sought as well because of a high rate of co-occurrence (Rauch, Otolaryngol Clin North Am 43:1011–1017, 2010). Treatment begins with...


Monday 9 March 2015

Evolution and population genomics of the Lyme borreliosis pathogen, Borrelia burgdorferi.

Authors: Seifert SN, Khatchikian CE, Zhou W, Brisson D Abstract Population genomic studies have the potential to address many unresolved questions about microbial pathogens by facilitating the identification of genes underlying ecologically important traits, such as novel virulence factors and adaptations to humans or other host species. Additionally, this framework improves estimations of population demography and evolutionary history to accurately reconstruct recent epidemics and identify the molecular and environmental factors that resulted in the outbreak. The Lyme disease bacterium, Borrelia burgdorferi, exemplifies the power and promise of the application of population genomics to microbial pathogens. We discuss here the future of evolutionary studies in B. burgdorferi, focus...


Saturday 7 March 2015

First arrived takes all: inhibitory priority effects dominate competition between co-infecting Borrelia burgdorferi strains

Different strains of Borrelia burgdorferi, the causative agent of Lyme disease, induce a strong inhibitory priority effect in the mouse host and help the most infective bacterial strains to become more prevalent. (Source: BMC Microbiology)


Friday 6 March 2015

Lyme CNS Infection Mimics Stroke in TeenagerLyme CNS Infection Mimics Stroke in Teenager

Lyme neuroborreliosis can mimic stroke or epilepsy and should be ruled out in some cases of sudden-onset meningoencephalitis with neuropsychiatric symptoms, researchers reported. Medscape Medical News (Source: Medscape Medical News Headlines)

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Thursday 5 March 2015

Human seroprevalence against Borrelia burgdorferi sensu lato in two comparable regions of the eastern Alps is not correlated to vector infection rates

This study describes occurrence and geographic dispersion of Borrelia spp. in the Tyrols, discusses possible reasons for significant differences in human seroprevalence, and indicates that prevalence of Borrelia in vector ticks is not a direct predictive factor for the local seroprevalence in humans. (Source: Ticks and Tick borne Diseases)


Thursday 5 March 2015

Genetic variation in transmission success of the Lyme borreliosis pathogen Borrelia afzelii

Publication date: Available online 4 March 2015 Source:Ticks and Tick-borne Diseases Author(s): Nicolas Tonetti , Maarten J. Voordouw , Jonas Durand , Séverine Monnier , Lise Gern The vector-to-host and host-to-vector transmission steps are the two critical events that define the life cycle of any vector-borne pathogen. We expect negative genetic correlations between these two transmission phenotypes, if parasite genotypes specialized at invading the vector are less effective at infecting the vertebrate host and vice versa. We used the tick-borne bacterium Borrelia afzelii, a causative agent of Lyme borreliosis in Europe, to test whether genetic trade-offs exist between tick-to-host, systemic (host-to-tick), and a third mode of co-feeding (tick-to-tick) transmission. We worked with six ...

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Wednesday 4 March 2015

Management of Pediatric Patients with Synovial Fluid White Blood-Cell Counts of 25,000 to 75,000 Cells/mm3 After Aspiration of the Hip

Conclusions: Septic arthritis of the hip is the most common ultimate diagnosis in children with synovial fluid WBC values of 25,000 to 75,000 cells/mm3 (25 to 75 x 109 cells/L) following hip aspiration, and it should be high on the differential diagnosis, even in cases with synovial fluid WBC values of <50,000 cells/mm3 (<50 x 109 cells/L). Level of Evidence: Diagnostic Level IV. See Instructions for Authors for a complete description of levels of evidence. (Source: The Journal of Bone and Joint Surgery)


Wednesday 4 March 2015

Molecular and pharmacological characterization of the Chelicerata pyrokinin receptor from the southern cattle tick, Rhipicephalus (Boophilus) microplus.

Authors: Yang Y, Nachman RJ, Pietrantonio PV Abstract We identified the first pyrokinin receptor (Rhimi-PKR) in Chelicerata and analyzed structure-activity relationships of cognate ligand neuropeptides and their analogs. Based on comparative and phylogenetic analyses, this receptor, which we cloned from larvae of the cattle tick Rhipicephalus microplus (Acari: Ixodidae), is the ortholog of the insect pyrokinin (PK)/pheromone biosynthesis activating neuropeptide (PBAN)/diapause hormone (DH) neuropeptide family receptor. Rhimi-PKR functional analyses using calcium bioluminescence were performed with a developed stable recombinant CHO-K1 cell line. Rhimi-PKR was activated by four endogenous PKs from the Lyme disease vector, the tick Ixodes scapularis (EC50s range: 85.4 nM-546 nM), a...


Tuesday 3 March 2015

Provider Knowledge, Attitudes, and Practices Regarding Lyme Disease in Arkansas

Abstract Lyme disease (LD), a vector-borne disease, causes illness for many individuals in the United States. All of the conditions for the promulgation of LD are present in one Southern state in the United States; yet this state reports lower numbers of LD than adjacent states. The purpose of this study was to determine associations between this Southern state’s primary care providers’ knowledge and attitudes regarding the diagnosis and reporting of LD. A quantitative, cross-sectional study was conducted via a mailed questionnaire by the Arkansas Department of Health to 2,693 primary care providers. Respondents were 660 primary care providers from all regions of this state. Secondary data were analyzed using descriptive, Chi square, and logistic regression techniques. Analys...


Monday 2 March 2015

Teenager with stroke symptoms actually had Lyme disease

(American College of Emergency Physicians) A Swiss teenager, recently returned home from a discotheque, came to the emergency department with classic sudden symptoms of stroke, only to be diagnosed with Lyme disease. The highly unusual case presentation was published online last Thursday in Annals of Emergency Medicine. (Source: EurekAlert! - Infectious and Emerging Diseases)


Monday 2 March 2015

Acute Lyme Neuroborreliosis With Transient Hemiparesis and Aphasia

We report a case of a female teenager presenting with sudden-onset aphasia and transient right-sided faciobrachial hemiplegia, along with headache and agitation. Ischemia, vasculitis, or another structural lesion was excluded by brain imaging. Toxicologic evaluation results were negative. Cerebral perfusion computed tomography and electroencephalography showed left parietotemporal brain dysfunction. Lumbar puncture result, although atypical, suggested bacterial infection and intravenous ceftriaxone was initiated. Finally, microbiological cerebrospinal fluid analysis revealed Lyme neuroborreliosis, showing specific intrathecal antibody production and high level of C-X-C motif chemokine 13. The patient rapidly recovered. To our knowledge, this report for the first time illustrates that acute...

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Sunday 1 March 2015

In patients with defects in Toll‐like and Interleukin‐1 receptor (TIR)‐dependent signalling septic arthritis may present like Juvenile Idiopathic Arthritis

This article is protected by copyright. All rights reserved. (Source: Pediatric Allergy and Immunology)


Sunday 1 March 2015

First Detection of Borrelia burgdorferi sensu lato DNA in Serum of the Wild Boar ( Sus scrofa ) in Northern Portugal by Nested-PCR

In this study, Borrelia DNA was detected for the first time by nested-PCR in three different sera, suggesting that the wild boar may be a potential reservoir for this spirochete. Sequencing results show 100% similarity with Borrelia afzelii. Further studies are needed to evaluate the public health risks associated with boar hunting. (Source: EcoHealth)


Sunday 1 March 2015

Characteristics of seroconversion and implications for diagnosis of post-treatment Lyme disease syndrome: acute and convalescent serology among a prospective cohort of early Lyme disease patients

Abstract Two-tier serology is often used to confirm a diagnosis of Lyme disease. One hundred and four patients with physician diagnosed erythema migrans rashes had blood samples taken before and after 3 weeks of doxycycline treatment for early Lyme disease. Acute and convalescent serologies for Borrelia burgdorferi were interpreted according to the 2-tier antibody testing criteria proposed by the Centers for Disease Control and Prevention. Serostatus was compared across several clinical and demographic variables both pre- and post-treatment. Forty-one patients (39.4 %) were seronegative both before and after treatment. The majority of seropositive individuals on both acute and convalescent serology had a positive IgM western blot and a negative IgG western blot. IgG seroconvers...


Friday 27 February 2015

In Northeast, Weather Changes May Mean More Ticks, Earlier

Warming trend could affect the spread of Lyme disease, research suggests Source: HealthDay Related MedlinePlus Pages: Climate Change, Tick Bites (Source: MedlinePlus Health News)


Friday 27 February 2015

Prevalence of Borrelia burgdorferi -infected ticks from wildlife hosts, a response to Norris et al .

In a recent Letter to the Editor, Norris et al. questioned the validity of some of our data reported by Feria-Arroyo et al. The main issue investigated by us was the potential impact of climate change on the probable distribution of the tick vector Ixodes scapularis in the Texas-Mexico transboundary region,. As an ancillary issue, an analysis of sequence data for the intergenic spacer of Borrelia burgdorferi was conducted.. In the present letter, we provide further evidence supporting our original results, and advocate that extensive study of the population genetics of B. burgdorferi is needed in the Texas-Mexico transboundary region. (Source: Parasites and Vectors)


Wednesday 25 February 2015

Many California bird species host Lyme disease bacteria, study finds

Ticks carrying the bacterium responsible for Lyme disease are infesting Northern California’s birds and may be hitching rides on them into suburban settings, according to a new UC Berkeley study. (Source: Los Angeles Times - Science)


Wednesday 25 February 2015

Repeat or persistent Lyme disease: persistence, recrudescence or reinfection with Borrelia Burgdorferi?

Authors: Shapiro ED Abstract Whether or not Borrelia burgdorferi can persist after conventional treatment with antimicrobials has been a very controversial issue. Two recent studies took different approaches to try to answer this question. In one, investigators showed that, in each of 22 instances in 17 patients with two consecutive episodes of culture-proved erythema migrans, the strains of B. burgdorferi were different based on their genotypes. This indicated that the repeat episodes were due to new infections rather than recrudescence of the original infection. In another study, in which persistence of B. burgdorferi was assessed by using xenodiagnosis, no viable B. burgdorferi were cultured from ticks fed on any of the patients. There continues to be no evidence that viable B. ...

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Wednesday 25 February 2015

Prevalence of select vector-borne pathogens in stray and client-owned dogs from Algiers

Publication date: February 2015 Source:Comparative Immunology, Microbiology and Infectious Diseases, Volume 38 Author(s): Naouelle Azzag , Elisabeth Petit , Christelle Gandoin , Corinne Bouillin , Farida Ghalmi , Nadia Haddad , Henri-Jean Boulouis Data on the prevalence of vector-borne diseases agents infecting canines in Algeria is currently lacking. The purpose of this study is to assess by serological and molecular methods the prevalence of select arthropod borne-bacterial infections in client-owned and stray dogs. Antibodies to Anaplasma phagocytophilum were the most prevalent at 47.7%, followed by Borrelia burgdorferi s.l. at 37.6%, Ehrlichia canis at 30.0%, Bartonella henselae at 32.4% and Bartonella vinsonii subsp. berkhoffii at 27%. Seroprevalence was statistically significantly ...


Wednesday 25 February 2015

Brief Report: Long‐Term Assessment of Fibromyalgia in Patients With Culture‐Confirmed Lyme Disease

ConclusionFibromyalgia was observed in only 1% of 100 patients with culture‐confirmed early Lyme disease; this frequency is consistent with that observed in the general population. (Source: Arthritis and Rheumatism)


Wednesday 25 February 2015

Factors associated with preventive behaviors regarding Lyme disease in Canada and Switzerland: a comparative study

Conclusions: These results strongly suggest that social and contextual factors such as the epidemiological status of a region are important considerations to take into account when designing effective prevention campaigns for Lyme disease. It furthermore underlines the importance for public health authorities to better understand and monitor these factors in targeted populations in order to be able to implement preventive programs that are well adapted to a population and the epidemiological contexts therein. (Source: BMC Public Health)


Tuesday 24 February 2015

Zoonotic occupational diseases in forestry workers - Lyme borreliosis, tularemia and leptospirosis in Europe.

CONCLUSIONS: The prevalences of these three zoonotic diseases are not negligible and information targeting the public is needed. Moreover, the results highlight the lack of standardised surveys among different European countries. It was also noted that epidemiological data on leptospirosis are very scarce. PMID: 25780827 [PubMed - in process] (Source: Annals of Agricultural and Environmental Medicine : AAEM)

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Tuesday 24 February 2015

Discovery and targeted proteomics on cutaneous biopsies infected by Borrelia to investigate Lyme disease.

This study thus shows that a targeted SRM approach is a promising tool for the early direct diagnosis of Lyme disease with high sensitivity (<10 fmol OspC per mg of human skin biopsy). PMID: 25713121 [PubMed - as supplied by publisher] (Source: Molecular and Cellular Proteomics : MCP)


Tuesday 24 February 2015

Your NEJM Group Today: Groin Hernia in Adults, Late Lyme & Fatigue, Wisconsin IM Opportunities (FREE)

By The Editors NEJM Group offers so many valuable resources for practicing clinicians. Here's what we chose for you today: … (Source: Physician's First Watch current issue)


Friday 20 February 2015

Increasing Residential Proximity of Lyme Borreliosis Cases to High-Risk Habitats: A Retrospective Study in Central Bohemia, the Czech Republic, 1987–2010

Abstract An analysis of historical data on Lyme borreliosis in Central Bohemia between 1987–2010 has revealed that the rate of peri-domestic exposure, the proximity of patients’ residences to high-risk habitats, and the number of disease cases have been interdependent variables and that their common upturn can be dated back to the start of the 1990s or earlier. The data indicate that the disease rise is attributable to translocation of part of the at-risk population nearer to natural environments, rather than to mere intensification of people’s peri-domestic exposure at existing residential locations, or changes in the natural environment itself. (Source: EcoHealth)


Thursday 19 February 2015

Structural Mechanisms Underlying Sequence-Dependent Variations in GAG Affinities of Decorin Binding Protein A, a Borrelia burgdorferi Adhesin.

Authors: Morgan AM, Wang X Abstract Decorin binding protein A (DBPA) is an important surface adhesin of the bacterium Borrelia burgdorferi, the causative agent of Lyme disease. DBPA facilitates the bacteria's colonization of human tissue by adhering to glycosaminoglycan (GAG), a sulfated polysaccharide. Interestingly, DBPA sequence variation among different strains of Borrelia spirochetes is high, resulting in significant differences in their GAG affinities. However, the structural mechanisms contributing to these differences are unknown. We determined the solution structures of DBPAs from strain N40 of Borrelia burgdorferi and strain PBr of Borrelia gariini, two DBPA variants whose GAG affinities deviate significantly from strain B31, the most well studied version of DBPA. Our str...


Thursday 19 February 2015

Structural Mechanisms Underlying Sequence-Dependent Variations in GAG Affinities of Decorin Binding Protein A, a Borrelia burgdorferi Adhesin

Decorin binding protein A (DBPA) is an important surface adhesin of the bacterium Borrelia burgdorferi, the causative agent of Lyme disease. DBPA facilitates the bacteria’s colonization of human tissue by adhering to glycosaminoglycan (GAG), a sulfated polysaccharide. Interestingly, DBPA sequence variation among different strains of Borrelia spirochetes is high, resulting in significant differences in their GAG affinities. However, the structural mechanisms contributing to these differences are unknown. We determined the solution structures of DBPAs from strain N40 of Borrelia burgdorferi and strain PBr of Borrelia gariini, two DBPA variants whose GAG affinities deviate significantly from strain B31, the most well studied version of DBPA. Our structures revealed that significant dif...


Wednesday 18 February 2015

In a warmer world, ticks that spread disease are arriving earlier, expanding their ranges

In the northeastern United States, warmer spring temperatures are leading to shifts in the emergence of the blacklegged ticks that carry Lyme disease and other tick-borne pathogens. At the same time, milder weather is allowing ticks to spread into new geographic regions. (Source: ScienceDaily Headlines)

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Monday 16 February 2015

Integrin binding by Borrelia burgdorferi P66 facilitates dissemination but is not required for infectivity

Summary P66, a Borrelia burgdorferi surface protein with porin and integrin‐binding activities, is essential for murine infection. The role of P66 integrin‐binding activity in B. burgdorferi infection was investigated and found to affect transendothelial migration. The role of integrin binding, specifically, was tested by mutation of two amino acids (D205A,D207A) or deletion of seven amino acids (Del202–208). Neither change affected surface localization or channel‐forming activity of P66, but both significantly reduced binding to αvβ3. Integrin‐binding deficient B. burgdorferi strains caused disseminated infection in mice at 4 weeks post‐subcutaneous inoculation, but bacterial burdens were significantly reduced in some tissues. Following intravenous inoculation, the Del20...


Thursday 12 February 2015

BORRELIA BABESIA REMEDY (Babesia Microti, Borrelia Burgdorferi Nosode) Liquid [Deseret Biologicals, Inc.]

Updated Date: Feb 12, 2015 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))


Thursday 12 February 2015

Exploring the association between Morgellons disease and Lyme disease: identification of Borrelia burgdorferi in Morgellons disease patients

Conclusions: Our study using multiple detection methods confirms that MD is a true somatic illness associated with Borrelia spirochetes that cause Lyme disease. Further studies are needed to determine the optimal treatment for this spirochete-associated dermopathy. (Source: BMC Dermatology)

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Tuesday 10 February 2015

Forthcoming Issues

Lyme Disease (Source: Infectious Diseases Clinics of North America)


Tuesday 10 February 2015

Immunization with a recombinant subunit OspA vaccine markedly impacts the rate of newly acquired Borrelia burgdorferi infections in client-owned dogs living in a coastal community in Maine, USA

Background: In North America, Borrelia burgdorferi is the causative bacterial agent of canine Lyme borreliosis and is transmitted following prolonged attachment and feeding of vector ticks, Ixodes scapularis or Ixodes pacificus. Its prevention is predicated upon tick-avoidance, effective on-animal tick control and effective immunization strategies. The purpose of this study is to characterize dogs that are newly seropositive for Borrelia burgdorferi infection in relation to compliant use of a recombinant OspA canine Lyme borreliosis vaccine. Specifically, Preventive Fractions (PF) and Risk Ratios (RR) associated with the degree of vaccine compliancy (complete versus incomplete) are determined. Methods: 6,202 dogs were tested over a five year period in a single veterinary hospital utilizing...


Sunday 8 February 2015

Management of the marginal zone lymphomas.

Authors: Vannata B, Stathis A, Zucca E Abstract Marginal zone lymphomas (MZL) represent around 8 % of all non-Hodgkin lymphomas. During the last decades a number of studies have addressed the mechanisms underlying the disease development. Extranodal MZL lymphoma usually arises in mucosal sites where lymphocytes are not normally present from a background of either autoimmune processes, such as Hashimoto thyroiditis or Sjögren syndrome or chronic infectious conditions. In the context of a persistent antigenic stimulation, successive genetic abnormalities can progressively hit a B-cell clone among the reactive B-cells of the chronic inflammatory tissue and give rise to a MALT lymphoma. The best evidence of an etiopathogenetic link is available for the association between Helicobacter...


Friday 6 February 2015

The high cost of Lyme disease

The U.S. spends more than a billion dollars caring for patients who contract this tick-borne illness (Source: Health News: CBSNews.com)


Friday 6 February 2015

Lyme Disease More Serious, Costly Than Believed: Study

Prolonged illness in infected Americans costs up to $1.3 billion a year in treatments, researchers find (Source: WebMD Health)


Thursday 5 February 2015

Lyme Disease Costs Up to $1.3 Billion Per Year to Treat, Study Finds

New research from the Johns Hopkins Bloomberg School of Public Health suggests that a prolonged illness associated with Lyme disease in some patients is more widespread and serious than previously understood. (Source: Public Health News Headlines from Johns Hopkins)


Thursday 5 February 2015

Lyme disease costs up to $1. 3 billion per year to treat, study finds

New research suggests that a prolonged illness associated with Lyme disease is more widespread and serious in some patients than previously understood. (Source: ScienceDaily Headlines)


Thursday 5 February 2015

T2 Biosystems, Canon to develop Lyme disease test

T2 Biosystems and Canon U.S. Life Sciences team up to develop a diagnostic test panel for the rapid detection of Lyme disease. T2 Biosystems (NSDQ:TTOO) and Canon U.S. Life Sciences are teaming up to develop a diagnostic test panel for the rapid detection of Lyme disease. Canon, T2 Biosystems Inc.News Well, Diagnostics, Lyme diseaseread more (Source: Mass Device)


Thursday 5 February 2015

Lyme disease costs up to $1.3 billion per year to treat, study finds

(Johns Hopkins University Bloomberg School of Public Health) Lyme disease, transmitted by a bite from a tick infected by the Borrelia burgdorferi bacteria, had long been considered easy to treat, usually requiring a single doctor's visit and a few weeks of antibiotics for most people. But new research from the Johns Hopkins Bloomberg School of Public Health suggests that a prolonged illness associated with the disease in some patients is more widespread and serious than previously understood. (Source: EurekAlert! - Infectious and Emerging Diseases)

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Thursday 5 February 2015

T2 Biosystems And Canon U.S. Life Sciences Announce Joint Collaboration To Develop Novel Test Panel To Rapidly Detect Lyme Disease

T2 Biosystems, Inc. (Nasdaq:TTOO) a company developing innovative diagnostic products to improve patient health today announced that the company has entered into a multi-year, strategic agreement with Canon U.S. Life Sciences, Inc. to jointly develop a novel diagnostic test panel to rapidly detect Lyme disease, a tick-borne bacterial infection that, if left untreated, can cause chronic joint inflammation, neurological disorders and cognitive defects. (Source: Medical Design Online News)


Wednesday 4 February 2015

Tick-borne infections in horses from Tuscany, Italy

To estimate the prevalence of tick-borne pathogens in horses living in areas of Tuscany (Italy) with high risk of arthropod exposure, blood samples from 160 clinically healthy grazing horses were tested by PCR for Anaplasma phagocytophilum, Borrelia burgdorferi sensu lato (s.l.), Coxiella burnetii, Babesia caballi, and Theileria equi. Tick-borne infections were detected in 70 (43.75%) horses, in particular 43 animals (26.87%) resulted positive for T. equi, 41 (25.62%) for A. phagocytophilum, 6 (3.75%) for C. (Source: Journal of Equine Veterinary Science)

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Wednesday 4 February 2015

Health Care Costs, Utilization and Patterns of Care following Lyme Disease

This study utilizes retrospective data on medical claims and member enrollment for persons aged 0-64 years who were enrolled in commercial health insurance plans in the United States between 2006-2010. 52,795 individuals treated for Lyme disease were compared to 263,975 matched controls with no evidence of Lyme disease exposure. Results Lyme disease is associated with $2,968 higher total health care costs (95% CI: 2,807-3,128, p (Source: PLoS One)


Tuesday 3 February 2015

Co-feeding transmission in Lyme disease pathogens

Review Articles MAARTEN J. VOORDOUW, Parasitology, Volume 142 Issue 02, pp 290-302Abstract (Source: Parasitology)


Sunday 1 February 2015

Diseases from North America: focus on tick-borne infections.

Authors: Nathavitharana RR, Mitty JA Abstract Tick-borne infections are seen throughout the United States, with varying geographical locations. Many of these infections are also increasingly seen in Europe. Certain ticks (eg Ixodes) can transmit more than one infection. Diagnosis, particularly in early infection, can be challenging and therefore knowledge of the distinguishing clinical features and epidemiology of these diseases is importa