Lyme Disease News & Current Medical Research

The latest publications of scientific medical research, articles and news on Lyme disease from many resources are automatically displayed here.

List of latest Lyme news and medical research

Friday 29 August 2014

Prioritizing dermatoses: rationally selecting guideline topics

ConclusionDermatological professional organizations worldwide succeeded in developing guidelines for all top 20 topics. Respondents mostly agree with (inter)national guideline programmes and literature concerning the criteria important to selecting guideline topics. (Source: Journal of the European Academy of Dermatology and Venereology)

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Thursday 28 August 2014

Incidence and hospitalisation rates of Lyme borreliosis, France, 2004 to 2012

(Source: Eurosurveillance latest news)


Wednesday 27 August 2014

Genotyping of Borrelia from formalin‐fixed paraffin‐embedded skin biopsies of cutaneous borreliosis and tick bite reactions by assays targeting the intergenic spacer region, ospA and ospC genes

ConclusionsGenotyping of Borrelia can be easily implemented in a routine dermatopathology setting, especially as a fast method to confirm early cutaneous borreliosis. Genotyping could also enable earlier treatment of patients infected with invasive strains. (Source: British Journal of Dermatology)


Tuesday 26 August 2014

Comparison of survival patterns of northern and southern genotypes of the North American tick Ixodes scapularis (Acari: Ixodidae) under northern and southern conditions

Lyme borreliosis is more prevalent in the northern than the southern U.S. Northern Ixodes scapularis ticks did not consistently survive longer than southern ticks in laboratory trials. Both northern and southern ticks survived longer under northern than under southern conditions. Image: Ixodes scapularis nymph (courtesy Graham J. Hickling) (Source: Parasites and Vectors)


Tuesday 26 August 2014

Heart block and Lyme carditis

(Source: QJM)


Tuesday 26 August 2014

Review: Unraveling Lyme Disease

(Source: Arthritis and Rheumatism)

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Monday 25 August 2014

Case of tick‐associated rash illness caused by Amblyomma testudinarium

We report a case of tick‐associated rash illness (TARI), a new clinical entity of erythema migrans associated with a tick bite without infection of Lyme borreliosis agent. The patient, a 53‐year‐old man, went hiking in a mountainous area of Minoh City, Osaka Prefecture in October 2012. An erythematous macule with itching and a biting tick was found on his left thigh 2 days later, which gradually expanded. On the first visit to our department at the fifth day after hiking, an erythematous macule of 10 cm was recognized around the bite site. He had no systemic symptoms, and laboratory data were within normal limits. The tick was identified as a nymph of Amblyomma testudinarium. Histopathologically, perivascular infiltrates, mainly consisting of T lymphocytes, were seen in the dermis....


Sunday 24 August 2014

Risk of Lyme Disease Anytime in Northwest California

Researchers from CDPH and UC-Berkeley publish findings in peer-review journal, Ticks and Tick-borne Diseases. (Source: Disabled World)


Wednesday 20 August 2014

Lyme disease risk is year-round in Northwest California, according to new study

(DDC) Ticks that carry Lyme disease are active throughout the year in Northwest California, making the threat of Lyme disease year-round, according to new research conducted by researchers at California Department of Public Health Vector-borne Disease Section and University of California, Berkeley. Data will be published in an upcoming issue of the Elsevier peer review journal Ticks and Tick-borne Diseases. More information about Lyme disease is available from Bay Area Lyme Foundation, www.bayarealyme.org. (Source: EurekAlert! - Medicine and Health)


Tuesday 19 August 2014

Scoop on Lyme disease and progress

(NaturalNews) On May 22 and May 23 members from the Lyme disease community held a protest at the headquarters of the Infectious Diseases Society of America (IDSA) in Arlington, Virginia. Members from the chronic Lyme community held a sign of 722 names of those who wished to have been... (Source: NaturalNews.com)


Wednesday 13 August 2014

Lyme Disease

New England Journal of Medicine, Volume 371, Issue 7, Page 683-684, August 2014. (Source: New England Journal of Medicine)

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Wednesday 13 August 2014

UCSF Genomics Diagnostics Team Uses Next-Gen Sequencing as a ‘Laboratory-Developed Test’ to Reveal an Elusive Pathogen’s DNA and Save a Teen’s Life

It took UCSF physicians just 48 hours to identify the bacteria in cerebrospinal fluid that was causing fourteen-year-old Joshua Osborn’s hydrocephalus and status epilepticus There’s rich irony in the FDA’s  recent announcement that it would move forward with plans to regulate “laboratory-developed tests ” (LDTs) just weeks after the national media published stories about how innovative […] (Source: Dark Daily)


Wednesday 13 August 2014

Decorin binding proteins A and B in the serodiagnosis of Lyme disease in North America.

Authors: Arnaboldi PM, Sambir M, Dattwyler RJ Abstract The laboratory diagnosis of Lyme disease is based upon the detection of antibodies generated against B. burgdorferi using a two-tier assay, consisting, typically, of an ELISA followed by a western blot. This system, put into place to address nonspecificity associated with standalone first tier assays, is insensitive in the diagnosis of early infection, when most people seek care. The use of bacterial lysates or whole protein antigens as first tier assay targets contributes to nonspecificity due, in part, to the presence of 'cross-reactive' epitopes that are also found in other bacteria. This precludes their use as sensitive standalone assays. The use of peptides containing linear epitopes that are highly specific for B. burgdor...


Saturday 9 August 2014

Repel ticks with this natural oil

(NaturalNews) With summer in full bloom and more and more cases of Lyme disease being reported, many are searching for ways to repel ticks without having to resort to harsh chemicals. Luckily, there is one sweet-smelling alternative that is proving to be quite powerful in the fight... (Source: NaturalNews.com)


Thursday 7 August 2014

Interaction of BBK32 with Fibronectin [Protein Structure and Folding]

BBK32 is a fibronectin (FN)-binding protein expressed on the cell surface of Borrelia burgdorferi, the causative agent of Lyme disease. There is conflicting information about where and how BBK32 interacts with FN. We have characterized interactions of a recombinant 86-mer polypeptide, “Bbk32,” comprising the unstructured FN-binding region of BBK32. Competitive enzyme-linked assays utilizing various FN fragments and epitope-mapped anti-FN monoclonal antibodies showed that Bbk32 binding involves both the fibrin-binding and the gelatin-binding domains of the 70-kDa N-terminal region (FN70K). Crystallographic and NMR analyses of smaller Bbk32 peptides complexed, respectively, with 2–3FNI and 8–9FNI, demonstrated that binding occurs by β-strand addition. Isothermal titration calorimetr...



Wednesday 30 July 2014

Seeks, Finds, threats Lyme disease!

Lyme borreliosis is a disease commonly found in humans. Here we report the case of a young, healthy girl presenting with symptomatic first- and second-degree atrioventricular blocks secondary to cardiac myocarditis. The disappearance of the conduction anomaly after antibiotic treatment confirmed Lyme disease before the results from the serology. Therefore, when a healthy, young person suddenly presents with an atrioventricular conduction block, physicians should consider a diagnosis of Lyme disease. (Source: The American Journal of Emergency Medicine)


Monday 28 July 2014

Advice varies for suspected Lyme disease.

Authors: Eggertson L PMID: 25070984 [PubMed - as supplied by publisher] (Source: cmaj)


Monday 28 July 2014

Antibodies to Endothelial Cell Growth Factor and Obliterative Microvascular Lesions in the Synovium of Patients With Antibiotic‐Refractory Lyme Arthritis

ConclusionThe correlations of ECGF autoantibody reactivity with obliterative microvascular lesions imply that these autoantibodies may be involved in the obliterative process, suggesting that anti‐ECGF antibodies have specific pathologic consequences in the synovial tissue of patients with antibiotic‐refractory Lyme arthritis. (Source: Arthritis and Rheumatism)


Monday 21 July 2014

Lyme Disease Risk Influences Human Settlement in the Wildland-Urban Interface: Evidence from a Longitudinal Analysis of Counties in the Northeastern United States.

This study provides some of the first evidence of human behavioral responses to Lyme disease risk via settlement decisions. PMID: 25048372 [PubMed - as supplied by publisher] (Source: The American Journal of Tropical Medicine and Hygiene)


Friday 18 July 2014

Lyme disease in Haryana, India

Vijayeeta Jairath, Manu Sehrawat, Nidhi Jindal, VK Jain, Parul AggarwalIndian Journal of Dermatology, Venereology, and Leprology 2014 80(4):320-323Lyme disease is a multiorgan animal-borne disease caused by the spirochete Borrelia burgdorferi. This case series highlights its presence in Haryana, a nonendemic zone. The first case was a 27-year-old housewife who presented with an annular erythematous patch with a central papule following an insect bite on the left upper arm. The second case was a 32-year-old farmer who gave a history of insect bite on the right arm followed by the development of an erythematous patch with a central blister. The third case, a 17-year-old boy presented with a history of tick bite over right thigh and a typical bull's eye lesion with central ulceration. ...

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Friday 18 July 2014

Intermediate uveitis in children and young adults: differences in clinical course, associations and visual outcome

Conclusions IU with onset in childhood and early adulthood showed a similar visual course at intermediate follow-up. Associated diseases and complication patterns differed between children and young adults. (Source: British Journal of Ophthalmology)


Monday 14 July 2014

Culling Deer Herd Curbs Lyme Disease, Study Says

Title: Culling Deer Herd Curbs Lyme Disease, Study SaysCategory: Health NewsCreated: 7/11/2014 5:35:00 PMLast Editorial Review: 7/14/2014 12:00:00 AM (Source: MedicineNet Hepatitis C General)


Monday 7 July 2014

Resurrecting the 'yuppie vaccine'

Nature Medicine 20, 698 (2014). doi:10.1038/nm0714-698 Author: Cassandra Willyard The only vaccine ever approved to protect against Lyme disease was pulled off the market in 2002, and drugmakers have yet to offer an alternative. What's taking so long? Cassandra Willyard investigates. (Source: Nature Medicine)


Monday 7 July 2014

Babesiosis in Pregnancy.

CONCLUSION:: Diagnosis of babesiosis in pregnancy requires a high index of suspicion to ensure early treatment and optimal pregnancy outcomes. PMID: 25004307 [PubMed - as supplied by publisher] (Source: Obstetrics and Gynecology)

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Monday 7 July 2014

Veterinarian in Indiana Warns of Leptospirosis and Lyme Disease Dangers

(Source: Medical News (via PRIMEZONE))


Friday 4 July 2014

Properties of P13 Borrelia Porin [Microbiology]

P13 is one of the major outer membrane proteins of Borrelia burgdorferi. Previous studies described P13 as a porin. In the present study some structure and function aspects of P13 were studied. P13 showed according to lipid bilayer studies a channel-forming activity of 0.6 nanosiemens in 1 m KCl. Single channel and selectivity measurements demonstrated that P13 had no preference for either cations or anions and showed no voltage-gating up to ±100 mV. Blue native polyacrylamide gel electrophoresis was used to isolate and characterize the P13 protein complex in its native state. The complex had a high molecular mass of about 300 kDa and was only composed of P13 monomers. The channel size was investigated using non-electrolytes revealing an apparent diameter of about 1.4 nm with a 400-Da mol...


Thursday 3 July 2014

One Tick Bite Can Equal Two Infections

In New York state study, 1 in 10 of the bugs carried both Lyme disease and babesiosis (Source: WebMD Health)


Thursday 3 July 2014

BorreliaBase: a phylogeny-centered browser of Borrelia genomes

Conclusions: With a genome phylogeny at its center, BorreliaBase allows online identification of hypervariable lipoprotein genes, potential regulatory elements, and recombination footprints by providing evolution-based expectations of sequence variability at each genomic locus. The phylo-centric design of BorreliaBase (http://borreliabase.org) is a novel model for interactive browsing and comparative analysis of bacterial genomes online. (Source: BMC Bioinformatics - Latest articles)

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Wednesday 2 July 2014

Lyme disease "doesn't kill you, but it squeezes every drop of life from you"

Summer is a high-risk season for Lyme disease, which is caused by a bacteria transmitted by ticks. Dr. Bernard Raxlen of Lyme Resource Medical in New York explains what to watch out for and how to treat it. (Source: Health News: CBSNews.com)


Tuesday 1 July 2014

Reducing deer populations may reduce risk of Lyme disease

(Entomological Society of America) After a 13-year study was conducted, researchers in Connecticut have found that reduced deer populations can lead to a reduction in Lyme disease cases. The results of their study are published in the Journal of Medical Entomology. (Source: EurekAlert! - Infectious and Emerging Diseases)


Monday 30 June 2014

Update: Lyme Disease

Lyme disease is probably the most common tick-borne illness in the U.S., and the best understood. It's a regional disease, very common in some areas, vanishingly rare in others for reasons that aren't yet clear. There are about 35,000 cases reported yearly in the U.S., but this likely underestimates the true incidence as many people either don't seek help or are not properly diagnosed. (Source: Forbes.com Healthcare News)



Friday 27 June 2014

Inside a top school’s science program

Students in the science research program at Burnt Hills-Ballston Lake High School have reclassified stars, presented at the prestigious Intel Science Talent Search competition and other conferences and met with top scientists researching in their field of interest. “The program definitely changed my life and I’m 100 percent grateful for the opportunity,” says Katie Bashant, who is spending her summer in a research lab focused on Lyme disease at University of Utah. Bashant is a junior at the… (Source: bizjournals.com Health Care:Physician Practices headlines)

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Friday 27 June 2014

UTSA and SwRI award $250,000 to advance clean emissions, explore antimicrobials

(University of Texas at San Antonio) Southwest Research Institute and The University of Texas at San Antonio today announced funding for two new joint research projects to advance clean emission technologies and study novel antimicrobials targeting Lyme disease. Funding through the organizations' Connecting through Research Partnerships program has been granted for $250,000 through August 2015 -- $125,000 for each project. (Source: EurekAlert! - Biology)


Friday 27 June 2014

BorrelIa InfectIon In Ixodes pararIcInus tIcks (acarI: Ixodidae) from northwestern argentina.

Authors: Nava S, Barbieri AM, Maya L, Colina R, Mangold AJ, Labruna MB, Venzal JM Abstract The aim of this work was to describe for the first time the presence of Borrelia burgdorferi sensu lato infecting ticks in Argentina. Unfed specimens of Ixodes pararicinus collected from vegetation in Jujuy Province were tested for Borrelia infection by PCR targeting the gene flagellin (fla), the rrfA-rrlB intergenic spacer region (IGS) and the 16S rDNA (rrs ) gene. One male and one female of I. pararicinus collected in Jujuy were found to be positive to Borrelia infection with the three molecular markers tested. Phylogenetically, the Borrelia found in I. pararicinus from Jujuy belongs to the B. burgdorferi s.l complex, and it was similar to one of the genospecies detected in I. aragaoi from ...


Thursday 26 June 2014

Primary leptomeningeal CNS lymphoma presenting as bilateral facial nerve palsy

Bilateral Facial Nerve Palsy (BFNP) is an extremely rare condition that can occur in the central nervous system (CNS) infectious diseases (Lyme disease, meningitis, syphilis), immuno-inflammatory disorders (Guillain–Barrè syndrome, neurosarcoidosis), or in potentially life-threatening diseases, such as hematologic malignancies . Primary CNS lymphoma (PCNSL) is a rare tumor, whose most common subtype is the diffuse large B cell lymphoma (DLBCL). It is typically confined to the CNS at diagnosis, and represents 2.2% of all the CNS neoplasms . Patients usually present with encephalopatic or focal signs, or, more infrequently, with cranial nerve palsies, which tend to follow the leptomeningeal involvement . The isolated leptomeningeal PCNSL, without magnetic resonance imaging (MRI) evidence ...


Thursday 26 June 2014

Respiratory modulation of cardiac vagal tone in Lyme disease.

CONCLUSION: Respiratory modulation of cardiac vagal tone is impaired in Lyme disease, which suggests that Lyme disease may directly affect the vagus nerve or the brainstem. PMID: 24976922 [PubMed] (Source: World Journal of Cardiology)


Wednesday 25 June 2014

Innate immunity networks during infection with Borrelia burgdorferi.

Authors: Oosting M, Buffen K, van der Meer JW, Netea MG, Joosten LA Abstract Abstract The recognition of Borrelia species represents a complex process in which multiple components of the immune system are involved. In this review, we summarize the interplay between the host innate system and Borrelia spp., from the recognition by pattern recognition receptors (PRRs) to the induction of a complex network of proinflammatory mediators. Several PRR families are crucial for recognition of Borrelia spp., including Toll-like receptors (TLRs) and Nucleotide Oligomerization Domain (NOD)-like receptors (NLRs). TLR-2 is crucial for the recognition of outer surface protein (Osp)A from Borrelia spp. and together with TLR8 mediates phagocytosis of the microorganism and production of type I inter...


Wednesday 25 June 2014

Unraveling lyme disease

(Source: Arthritis and Rheumatism)


Wednesday 25 June 2014

The effectiveness of permethrin-treated deer stations for control of the Lyme disease vector Ixodes scapularis on Cape Cod and the islands: a five-year experiment

When white-tailed deer visit corn-baited "4-poster" feeding stations, they come into contact with permethrin-treated rollers. In the 5-yr controlled experiment reported here, this host-targeted technology caused a reduction in tick abundance, but the effect was small compared to other studies. Image: White-tailed deer visiting a treated feeding station with inset image of a blacklegged tick. (Source: Parasites and Vectors)

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Wednesday 25 June 2014

New Insights Into Stages of Lyme Disease Symptoms From a Novel Hospital-Based Registry.

CONCLUSION: The difference between symptoms in the acutely infected patients and those experiencing persistent symptoms is not as large as initially thought. PMID: 24970880 [PubMed - as supplied by publisher] (Source: Primary Care)


Monday 23 June 2014

SwRI, UTSA to jointly pursue pair of novel research projects

Southwest Research Institute (SwRI) and The University of Texas at San Antonio (UTSA) have secured $250,000 in funding for a pair of joint research projects designed to advance clean emission technologies and to study novel antimicrobials targeting Lyme disease. Each project will receive $125,000 from the organizations’ Connecting through Research Partnerships program through August 2015. The Connect program, established in 2010 by SwRI and the UTSA Office of the Vice President for Research,… (Source: bizjournals.com Health Care:Biotechnology headlines)


Friday 20 June 2014

Single tick bite can pack double pathogen punch

People who get bitten by a blacklegged tick have a higher-than-expected chance of being exposed to more than one pathogen at the same time. "We found that ticks are almost twice as likely to be infected with two pathogens -- the bacterium that causes Lyme disease and the protozoan that causes babesiosis -- than we would have expected," said a professor of biology involved in a recent study. (Source: ScienceDaily Headlines)


Tuesday 17 June 2014

Treatments for Chronic Lyme Disease (PTLDS)

Learn how chronic Lyme disease is diagnosed and what treatments can help. (Source: WebMD Health)


Tuesday 17 June 2014

Baby Boom for Ticks, Lyme Disease Carriers in New EnglandBaby Boom for Ticks, Lyme Disease Carriers in New England

Large numbers of ticks, the parasites that carry Lyme disease, are expected to emerge in New England in the coming weeks, experts said on Friday. Reuters Health Information (Source: Medscape Medical News Headlines)


Tuesday 17 June 2014

Increased diversity of zoonotic pathogens and Borrelia burgdorferi strains in established versus incipient Ixodes scapularis populations across the Midwestern United States.

Authors: Hamer SA, Hickling GJ, Walker ED, Tsao JI Abstract The center of origin theory predicts that genetic diversity will be greatest near a species' geographic origin because of the length of time for evolution. By corollary, diversity will decrease with distance from the origin; furthermore, invasion and colonization are frequently associated with founder effects that reduce genetic variation in incipient populations. The blacklegged tick, Ixodes scapularis, harbors a suite of zoonotic pathogens, and the geographic range of the tick is expanding in the upper Midwestern United States. Therefore, we posited that diversity of I. scapularis-borne pathogens across its Midwestern range should correlate with the rate of the range expansion of this tick as well as subsequent disease e...



Sunday 15 June 2014

Indianapolis Veterinarians Warn of Uptick in Lyme Disease in Pets

(Source: Medical News (via PRIMEZONE))


Saturday 14 June 2014

Baby boom for ticks, Lyme disease carriers, seen in New England

LOWELL Mass. (Reuters) - Large numbers of ticks, the parasites that carry Lyme disease, are expected to emerge in New England in the coming weeks, experts said on Friday. (Source: Reuters: Health)


Friday 13 June 2014

Lyme disease mysteries and miseries persist

Summer is peak season for Lyme disease infections, and if it's not caught early it can lead to long-term health problems (Source: Health News: CBSNews.com)


Wednesday 11 June 2014

CXCL13 and neopterin concentrations in cerebrospinal fluid of patients with Lyme neuroborreliosis and other diseases that cause neuroinflammation

Background: Laboratory diagnosis of Lyme neuroborreliosis (LNB) is partly based on the detection of intrathecal Borrelia burgdorferi-specific antibody production (increased antibody index (AI)). However, AI can be negative in patients with early LNB and, conversely, can remain elevated for months after antibiotic treatment. Recent studies suggested that the chemokine CXCL13 in the cerebrospinal fluid (CSF) is a biomarker for active LNB. Also, CSF neopterin-level determination has been used to assess the degree of neuroinflammation in a wide variety of diseases. Methods: CXCL13 concentrations were analyzed in CSF samples of 366 retrospectively identified individuals. The samples represented pretreatment LNB (38 patients), non-LNB comparison patients, tick-borne encephalitis, central nervous...


Wednesday 11 June 2014

Chronic coinfections in patients diagnosed with chronic Lyme disease: a systematic literature review

(Source: The American Journal of Medicine)

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Tuesday 10 June 2014

Borrelia burgdorferi genospecies detection by RLB hybridization in Ixodes cinus ticks from different sites of North-Eastern Poland.

Authors: Dunaj J, Zajkowska JM, Kondrusik M, Gern L, Rais O, Moniuszko A, Pancewicz S, Swierzbińska R Abstract Introduction. RLB (Reverse Line Blot Hybridization) is a molecular biology technique that might be used for Borrelia burgdorferi sensu lato (sl) DNA detection with genospecies specification. Among B. burgdorferi sl genospecies at least 7 are regarded as pathogenic in Europe. objective. The aim of the study was to evaluate the frequency of different Borrelia genospecies DNA detection in Ixodes ricinus ticks in the endemic area of North-Eastern Poland by using RLB. materials and method. Ixodes ricinus ticks were collected in May - June, from 6 different sites in North-Eastern Poland (Jakubin, Kolno, Grajewo, Suwałki, Siemiatycze, Białowieża) by flagging. Extracted DNA wa...


Monday 9 June 2014

A study on the association between infectious burden and Alzheimer's disease

ConclusionsIB consisting of CMV, HSV‐1, B. burgdorferi, C. pneumoniae and H. pylori is associated with AD. This study supports the role of infection/inflammation in the etiopathogenesis of AD. (Source: European Journal of Neurology)


Friday 6 June 2014

Lyme Disease

(Source: eMedicineHealth.com)


Friday 6 June 2014

Many Lyme Tests Unnecessary, Experts SayMany Lyme Tests Unnecessary, Experts Say

Most Lyme disease serologic tests were done according to diagnostic recommendations, but only 288,000 of the 2.4 million patients tested were infected; the estimated testing cost was $492 million. Medscape Medical News (Source: Medscape Infectious Diseases Headlines)


Thursday 5 June 2014

Lyme Disease’s Possible Bacterial Predecessor Found in Ancient Tick

A juvenile tick trapped in a 15-million- to 20-million-year-old piece of amber contains a bacterium that could be the oldest documented ancestor of the microbe that causes Lyme disease -- Read more on ScientificAmerican.com (Source: Scientific American - Official RSS Feed)

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Wednesday 4 June 2014

Don't Get Bugged This Summer!

Don't get bugged this summer! Learn about insect bites and stings, Lyme disease, tick bites and West Nile virus. (Source: What's New on MedlinePlus)


Wednesday 4 June 2014

Simple objective detection of human Lyme disease infection using immuno-PCR and a single recombinant hybrid antigen.

Authors: Halpern MD, Molins CR, Schriefer M, Jewett MW Abstract A serology-based, tiered approach has, to date, provided the most effective means of laboratory confirmation of clinically suspected cases of Lyme disease but lacks sensitivity in early disease and is often dependent on subjectively scored immunoblots. We recently demonstrated use of immuno-PCR (iPCR) for detection of B. burgdorferi antibodies in Lyme disease patient serum. To better understand the performance of the Lyme disease iPCR assay, the repeatability and the variability of the background of the assay across a healthy population (n=36) was analyzed. Both of these parameters were found to have coefficients of variation of less than 3%. Using eight antigen-specific iPCR assays and positive call thresholds establi...


Wednesday 4 June 2014

Acetate supplementation modulates brain adenosine metabolizing enzymes and adenosine A2A receptor levels in rats subjected to neuroinflammation

Conclusion: These results support the hypothesis that acetate supplementation can modulate brain CD73, AK and adenosine A2A receptor levels, and possibly influence purinergic signaling. (Source: Journal of Neuroinflammation)


Sunday 1 June 2014

[Two cases of proliferation of monoclonal and monotypic lymphocytes and plasma cells corresponding to acrodermatitis chronica atrophicans.]

Authors: Bertolotti A, Pham-Ledard A, Petrot D, Coindre MC, Brecheteau P, Mendes I, Vergier B, Beylot-Barry M Abstract BACKGROUND: While a dermal proliferation of monotypic monoclonal lymphocytes and plasma cells suggests above all cutaneous marginal zone lymphoma (CMZL) or plasmacytoma, it may also correspond to a Borrelia infection of which the clinic picture is evocative, as demonstrated in the cases presented herein. PATIENTS AND METHODS: The files of two patients were submitted for discussion at the regional multidisciplinary staff meeting on cutaneous lymphomas after review of the skin biopsies led to a diagnosis of plasmacytoma and CMZL on the basis of infiltrate containing abundant plasma cells. The infiltrates of both patients showed a kappa monotypic light chain and c...


Sunday 1 June 2014

A clinical, diagnostic, and ecologic perspective on human anaplasmosis in the Upper Midwest.

CONCLUSION: Continuing expansion of the range of the black-legged tick (Ixodes scapuloris), the principal vector of the disease, into areas heavily populated or visited by humans in the region likely will result in this pathogen becoming an even greater burden on human health. Efforts are needed to better characterize the current geographic distribution of human Anaplasma and Ehrlichia cases to identify emerging foci and to better understand the enzootic cycles that maintain the pathogens in the region. Improved diagnostics may assist with such efforts. PMID: 25118439 [PubMed - in process] (Source: WMJ)

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Friday 30 May 2014

Summer Insect Safety

Source: HealthDay - Related MedlinePlus Pages: Lyme Disease, Tick Bites (Source: MedlinePlus Health News)


Friday 30 May 2014

Canine infection with Dirofilaria immitis, Borrelia burgdorferi, Anaplasma spp., and Ehrlichia spp. in the United States, 2010-2012

The geographic distribution of canine vector-borne disease agents in the United States appears to be expanding. Monitoring canine test results is an important tool for accurately mapping the geographic distribution of these agents. Image: United States distribution maps for heartworm, Lyme disease, ehrlichiosis, and anaplasmosis. (Source: Parasites and Vectors)


Friday 30 May 2014

Ticks may have carried Lyme disease for more than 15 million years

A tiny tick trapped in a droplet of amber more than 15 million years ago appears to have been infected with a bacteria similar to the one that causes Lyme disease in humans, according to new research. (Source: Los Angeles Times - Science)


Thursday 29 May 2014

Amber discovery indicates Lyme disease is older than human race

Lyme disease is a stealthy, often misdiagnosed disease that was only recognized about 40 years ago, but new discoveries of ticks fossilized in amber show that the bacteria which cause it may have been lurking around for 15 million years -- long before any humans walked on Earth. The findings were made by researchers who studied 15-20 million-year-old amber from the Dominican Republic that offer the oldest fossil evidence ever found of Borrelia, a type of spirochete-like bacteria that to this day causes Lyme disease. (Source: ScienceDaily Headlines)


Thursday 29 May 2014

Population genetic structure of the Lyme disease vector Ixodes scapularis at an apparent spatial expansion front.

Authors: Kelly RR, Gaines D, Gilliam WF, Jory Brinkerhoff R Abstract Modeling and empirical evidence suggests that Lyme disease is undergoing geographic expansion from principal foci in the midwestern and northeastern United States. Virginia is at the southern edge of the current expansion zone and has seen dramatic rise in human Lyme disease cases since 2007, potentially owing to a recent increase in vector abundance. Ixodes scapularis is known throughout the eastern US but behavioral or physiological variation between northern and southern lineages might lead northern-variant ticks to more frequently parasitize humans. We hypothesized that recent spatial and numerical increase in Lyme disease cases is associated with demographic and/or spatial expansion of I. scapularis and that ...


Wednesday 28 May 2014

Minimal role of eastern fence lizards in borrelia burgdorferi transmission in central new jersey oak/pine woodlands.

MINIMAL ROLE OF EASTERN FENCE LIZARDS IN BORRELIA BURGDORFERI TRANSMISSION IN CENTRAL NEW JERSEY OAK/PINE WOODLANDS. J Parasitol. 2014 May 28; Authors: Rulison EL, Kerr KT, Dyer MC, Han S, Burke RL, Tsao JI, Ginsberg HS Abstract Abstract The Eastern fence lizard, Sceloporus undulatus, is widely distributed in eastern and central North America, ranging through areas with high levels of Lyme disease, as well as areas where Lyme disease is rare or absent. We studied the potential role of S. undulatus in transmission dynamics of Lyme spirochetes by sampling ticks from a variety of natural hosts at field sites in central New Jersey, and by testing the reservoir competence of S. undulatus for Borrelia burgdorferi in the laboratory. The infestation rate of ticks on fence liza...


Thursday 22 May 2014

Concerns Regarding a New Culture Method for B. burgdorferiConcerns Regarding a New Culture Method for B. burgdorferi

A novel, laboratory-developed test for Lyme disease has raised concerns about unacceptable numbers of false-positive results and is not approved by the FDA. Morbidity & Mortality Weekly Report (Source: Medscape Today Headlines)


Tuesday 20 May 2014

Update on Lyme Disease and Other Tick-borne Diseases: An Alert for New Hampshire CliniciansUpdate on Lyme Disease and Other Tick-borne Diseases: An Alert for New Hampshire Clinicians

New Hampshire continues to have one of the highest rates of Lyme disease in the nation. The New Hampshire Division of Public Health Services provides recommendations for healthcare providers. State Health Alerts (Source: Medscape Medical News Headlines)


Tuesday 20 May 2014

Genetic characterization of the human relapsing fever spirochete Borrelia miyamotoi in vectors and animal reservoirs of Lyme disease spirochetes in France

The genotype of the human pathogen B. miyamotoi circulates simultaneously with Lyme disease spirochetes in ticks and bank voles in France. Even though no human cases have been reported in France, surveillance of B. miyamotoi alone or in association with other spirochetes has to be improved. Image: Collection of ticks by flagging in Ardennes Forest, France. (Source: Parasites and Vectors)

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Monday 19 May 2014

What Causes Leg Pain?

Discussion “Growing pains” of the legs are a common complaint in children. Heterogeneous studies from 1928-2004 have found prevalence rates of 2.6-49.4% in children ages 4-19. The studies are heterogeneous because of time, location, and especially definition of growing pains. A study of 1445, 4-6 year olds in 2004 using a validated tool showed a prevalence rate of 36.9%. The definition of growing pains used by Peterson in the 2004 study is chronic “…intermittent (nonarticular) pains in both legs that generally occur late in the day or at night…” with a normal physical examination and laboratory testing (if any is done). The pain is in the thigh or calf muscles. The pain can occur over weeks or months. Patients should not have a history of trauma but bec...


Monday 19 May 2014

Monday's Housecall

THIS WEEK'S TOP STORIES Lyme disease Grassy and heavily wooded areas can be home to ticks, which can carry Lyme disease. Get tips on prevention and how to spot the telltale signs. Tips for dining in or out safely when you have food allergies Preparing meals carefully is vital when you or a family member [...] (Source: News from Mayo Clinic)


Thursday 15 May 2014

West Nile Virus and Lyme Disease Spread Across the U.S.

A new season of West Nile, Lyme and dengue has begun -- Read more on ScientificAmerican.com (Source: Scientific American - Official RSS Feed)


Thursday 15 May 2014

Tick-borne infections of animals and humans: a common ground.

Authors: Baneth G Abstract A wide variety of pathogens is transmitted from ticks to vertebrates including viruses, bacteria, protozoa and helminths. of which most have a life cycle that requires passage through the vertebrate host. Tick-borne infections of humans, farm and companion animals are essentially associated with wildlife animal reservoirs. While some flying insect-borne diseases of humans such as malaria, filariasis and Kala Azar caused by Leishmania donovani target people as their main host, major tick-borne infections of humans, although potentially causing disease in large numbers of individuals, are typically an infringement of a circulation between wildlife animal reservoirs and tick vectors. While new tick-borne infectious agents are frequently recognised, emerging ...


Wednesday 14 May 2014

Study Finds Obesity Can Have Negative Effect On Young Breast Cancer Patients

BOSTON (CBS) — A new study says obesity can have a negative effect on young breast cancer patients. Karen Hackett has shed 30 pounds since being diagnosed with breast cancer two years ago. “I’ve made exercise become a priority,” she says. “It’s just part of my day. I try to go sometime around the lunchtime hour and if I don’t, I can go in the evening.” A new study finds obesity leads to poorer outcomes for women like Hackett who were pre- or peri-menopausal when they were diagnosed with hormone-sensitive breast cancer. “That’s the novel finding here, we used to think that this association was really seen primarily in older women, here it’s being seen in young women,” said Dr. Clifford Hudis of Memorial Sloan Kettering ...

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Wednesday 14 May 2014

Chronic lymphomonocytic meningoencephalitis, oligoarthritis and erythema nodosum: report of Baggio-Yoshinari syndrome of long and relapsing evolution

We describe the case of a young female who, over one year, progressively presented with oligoarthritis, cognitive impairment, menigoencephalitis and erythema nodosum. Diagnosis was established by means of the clinical history and a positive serology to Borrelia burgdorferi sensu strictu. The patient received Ceftriaxone 2 g IV/day during 30 days, followed by 2 months of doxicycline 100 mg bid. Symptoms remitted and the Borrelia serology tests returned to normality. BYS is a new disease described only in Brazil, which has a raising frequency and deserves the attention from the country´s medical board because of clinical, epidemiological and laboratory differences from LD. Despite the fact that it is a hard-to-diagnose zoonosis, it is important to pursuit an early diagnosis because the symp...


Tuesday 13 May 2014

Potentially conflicting selective forces that shape the vls antigenic variation system in Borrelia burgdorferi.

This study provides empirical evidence that conflicting selection pressures on antigenic variation systems can limit the potential antigenic divergence in order to maintain proper molecular function. PMID: 24837669 [PubMed - as supplied by publisher] (Source: Infection, Genetics and Evolution)


Monday 12 May 2014

It's Spring – Time to Prevent Lyme Disease

(Source: eMedicineHealth.com)


Sunday 11 May 2014

Harsh Winter Does Little To Ease Lyme Disease Woes

PORTLAND, Maine (AP) — The harsh winter did nothing to cull the nationwide tick population, and health officials are primed for a warm season that could see the number of Lyme disease cases rise. In northern New England, the increase in cases of Lyme correlates with a growing population of deer ticks, which transmit the disease, state epidemiologist Stephen Sears said. In Maine and elsewhere, heavy snow acted as an insulating blanket that protected ticks from winter’s cold, state entomologist Charlene Donahue said. Nationwide, the number of cases of Lyme disease has held relatively steady over the past few years, and advocacy groups and federal agencies say they expect this spring, summer and fall to be active seasons for ticks and Lyme. “Everybody’s picking them off th...


Saturday 10 May 2014

Doctors: More Young People Developing Osteoporosis

BOSTON (CBS) – Physicians often refer to osteoporosis as a “Silent Problem” because many patients don’t know they even have it until after they break or fracture a bone. Now an increasing number of young people are developing this bone loss disease. Dr. Nathanial Clark, an endocrinologist at Beth Israel Deaconess in Plymouth, said, “Far more commonly what we are referring to are people generally say in the 40-60 year range, that are being looked at more carefully than previously, whereas before we looked mainly at people who were over the age of 65-70.” Faye Lakeman found out her bones were slowly deteriorating when she was in her early 50s. On a lark, she took part in a free bone screening at a grocery store. Faye’s husband Dan is also suffering from bone loss. “You ar...

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Saturday 10 May 2014

NIH News in Health

Shedding Light on Health Research Helps People and Pets Veterinarians and scientists study diseases that affect both pets and people to improve medical care for humans and our 4-legged friends. Tick Talk Block Tick Bites and Lyme Disease Tick-borne diseases are found in many areas across the country, and they’re on the rise. Do what […] (Source: NN/LM Middle Atlantic Region Blog)


Friday 9 May 2014

Local lyme disease company gets $1 million in federal funding

Immuno Technologies Inc., a Memphis-based medical research and development company has been awarded $1 million in federal funding to further develop technology that can help doctors rapidly diagnose Lyme disease. The funding comes through the National Institutes of Health’s Small Business Innovation Research grant program. Immuno Technologies does translational research for infectious diseases, with a focus on Lyme disease. This grant will fund the development of rapid diagnosis methods of Lyme… (Source: bizjournals.com Health Care:Physician Practices headlines)


Thursday 8 May 2014

Yale Researchers: New Tick-Borne Illness Common In Southern New England

NEW HAVEN, Connecticut (CBS) – A new study by Yale researchers suggests that a tick-borne infection similar to Lyme disease has become common in southern New England. Using a new antibody test, researchers found evidence that about 4-percent of people they checked showed evidence of previous Borrelia miyamotoi infection. The prevalence of Lyme disease is about 10 percent. “We expect this to be found wherever Lyme disease is found. It’s likely that that will be the case,” said Peter Krause, M.D., senior research scientist at the Yale School of Public Health and lead author of the study. “The full health impact of this disease is really uncertain at this point. We just have to do more research to determine what the full spectrum of the disease will be.” Borrelia miyamotoi is ...


Wednesday 7 May 2014

Tufts Study: Shock Wave Therapy Could Be Answer For Rotator Cuff Injuries

BOSTON (CBS) — Shoulder pain is one of the most common reasons people go to the doctor and rotator cuff injuries are one of the most common causes of shoulder pain. While most cases are treated with rest, pain killers and physical therapy, a new study out of Tufts Medical Center shows shock wave therapy could be the answer for some. The therapy involves administering sound wave pulses on the outside of the body. It has been used for years to break up “kidney stones” and now doctors in Europe are using it to treat rotator cuff tendonitis. “We found that high energy shock wave therapy is very useful for patients with specifically calcific tendonitis of the shoulder,” said Dr. Raveendhara Bannuru of Tufts Medical. Bannuru looked at 28 studies using shock wave the...


Tuesday 6 May 2014

Harvard Study: Mass. Health Reform Law Lowered Death Rates

BOSTON (CBS) — Harvard researchers estimate that Massachusetts health reform law has prevented some 320 deaths per year or, one life saved for each 830 people gaining coverage. WBZ NewsRadio 1030′s Diane Sterns reports  WBZ NewsRadio 1030WBZ NewsRadio 1030playpausejQuery(document).ready(function($) { cbs_audio_player_v2("audio-player-1"); });   A new study that now appears in the Annals of Internal Medicine says in the first four years after Massachusetts instituted health care reform in 2006, the mortality rate decreased by 2.9-percent. That percentage is compared to similar populations in states that didn’t expand health coverage. The state’s health care reform law has served as a model for the national Affordable Care Act. Benjamin Sommers, assistant profe...

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Tuesday 6 May 2014

Phylogeny of a relapsing fever Borrelia species transmitted by the hard tick Ixodes scapularis.

Authors: Barbour AG Abstract The discovery of Borrelia species that were related to the agents of relapsing fever but were transmitted by hard ticks rather than soft ticks challenged previous taxonomies based largely on microbe-host specificities and geographic considerations. One of these newly-identified organisms is the Borrelia miyamotoi sensu lato strain LB-2001 from North America and transmitted by Ixodes scapularis. This or related strains have been identified as the cause of human disease, but comparatively little is known about their biology or genetics. Using recently acquired chromosome sequence of LB-2001 together with database sequences and additional sequences determined here, I carried out comparisons of the several species of Borrelia, including those in the two maj...


Tuesday 6 May 2014

It's Spring - Time to Prevent Lyme Disease

Source: Centers for Disease Control and Prevention Related MedlinePlus Page: Lyme Disease (Source: MedlinePlus Health News)


Thursday 1 May 2014

[Public health pests : Arthropods and rodents as causative disease agents as well as reservoirs and vectors of pathogens].

Authors: Faulde M, Freise J Abstract Globally, infectious diseases pose the most important cause of death. Among known human pathogenic diseases, approximately 50 % are zoonoses. When considering emerging infectious diseases separately 73 % currently belong to the group of zoonoses. In Central Europe, hard ticks show by far the biggest potential as vectors of agents of human disease. Lyme borreliosis, showing an estimated annual incidence between 60,000 and 214,000 cases is by far the most frequent tick-borne disease in Germany. Continually, formerly unknown disease agents could be discovered in endemic vector species. Additionally, introduction of new arthropod vectors and/or agents of disease occur constantly. Recently, five mosquito species of the genus Aedes have been newly...


Thursday 1 May 2014

[Important vector-borne infectious diseases among humans in Germany : Epidemiological aspects].

Authors: Frank C, Faber M, Hellenbrand W, Wilking H, Stark K Abstract Vector-borne infections pathogenic to humans play an important role in Germany. The relevant zoonotic pathogens are either endemic throughout Germany (e.g. Borrelia burgdorferi sensu latu) or only in specific regions, e.g. tick-borne encephalitis (TBE) virus and hantavirus. They cause a substantial burden of disease. Prevention and control largely rely on public advice and the application of personal protective measures (e.g. TBE virus vaccination and protection against vectors). High quality surveillance and targeted epidemiological studies are fundamental for the evaluation of temporal and spatial risks of infection and the effectiveness of preventive measures. Aside from endemic pathogens, vector-borne infecti...

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Thursday 1 May 2014

The lymphocyte transformation test for the diagnosis of Lyme borreliosis could fill a gap in the difficult diagnostics of borreliosis.

This article is protected by copyright. All rights reserved. (Source: Clinical Microbiology and Infection)


Thursday 1 May 2014

[Threat of transmission of infectious pathogens by Ixodes ricinus ticks in Germany].

Authors: Dobler G, Fingerle V, Hagedorn P, Pfeffer M, Silaghi C, Tomaso H, Henning K, Niedrig M Abstract Tick-transmitted diseases are of great importance for the general health of the German population. Several viruses, such as tick-borne encephalitis virus (TBEV), Uukuniemi virus, Tribec virus, Eyach virus or bacteria, such as Borrelia, Rickettsiae, Francisella tularensis, Anaplasma phagocytophilum, Candidatus Neoehrlichia mikurensis (CNM) and Coxiella burnetii were detected in the most prominent tick in Germany, the hard tick Ixodes ricinus. While infections, such as TBE and Lyme disease are well known, other infections are hardly known even among experts. Although there have been a few descriptions of isolated cases in Germany, a systematic investigation regarding the distribut...


Thursday 1 May 2014

Dityrosine Network Influences Borrelial Persistence in Ticks [Microbiology]

Ixodes scapularis ticks transmit a wide array of human and animal pathogens including Borrelia burgdorferi; however, how tick immune components influence the persistence of invading pathogens remains unknown. As originally demonstrated in Caenorhabditis elegans and later in Anopheles gambiae, we show here that an acellular gut barrier, resulting from the tyrosine cross-linking of the extracellular matrix, also exists in I. scapularis ticks. This dityrosine network (DTN) is dependent upon a dual oxidase (Duox), which is a member of the NADPH oxidase family. The Ixodes genome encodes for a single Duox and at least 16 potential peroxidase proteins, one of which, annotated as ISCW017368, together with Duox has been found to be indispensible for DTN formation. This barrier influences pathogen s...


Thursday 1 May 2014

A Tale of Two Syndromes: Lyme Disease Preceding Postural Orthostatic Tachycardia Syndrome

We report a short series of two women who present with persistent symptoms of orthostatic intolerance consistent with POTS after treated Lyme disease. (Source: Annals of Noninvasive Electrocardiology)


Thursday 1 May 2014

Experiences of patients identifying with chronic Lyme disease in the healthcare system: a qualitative study

Conclusions: Participants reported a significant decline in health status associated with chronic Lyme disease and were often unsatisfied with care in conventional settings. Negative experiences were associated with reports of dismissive, patronizing, and condescending attitudes. Positive experiences were associated with providers who were reported to be attentive, optimistic, and supportive. Consultations with CAM practitioners and use of CAM therapies were common. Actively engaged and sympathetic clinical encounters may foster greater satisfaction in healthcare settings. (Source: BMC Family Practice)


Wednesday 30 April 2014

Lyme Disease

New England Journal of Medicine, Volume 370, Issue 18, Page 1724-1731, May 2014. (Source: New England Journal of Medicine)

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Monday 28 April 2014

Lyme disease risk not amplified in a species-poor vertebrate community: Similar Borrelia burgdorferi tick infection prevalence and OspC genotype frequencies.

Authors: States SL, Brinkerhoff RJ, Carpi G, Steeves TK, Folsom-O'Keefe C, Deveaux M, Diuk-Wasser MA Abstract The effect of biodiversity declines on human health are currently debated, but empirical assessments are lacking. Lyme disease provides a model system to assess relationships between biodiversity and human disease because the etiologic agent, Borrelia burgdorferi, is transmitted in the United States by the generalist black-legged tick (Ixodes scapularis) among a wide range of mammalian and avian hosts. The 'dilution effect' hypothesis predicts that species-poor host communities dominated by white-footed mice (Peromyscus leucopus) will pose the greatest human risk because P. leucopus infects the largest numbers of ticks, resulting in higher human exposure to infected I. scap...


Saturday 26 April 2014

Avoiding tick-borne illnesses for people and pets

Paul Mead, M.D., and Liz Murphy, DVM, talk about tick-borne illnesses in humans and dogs. Tick-borne illnesses like Lyme disease and Rocky Mountain Spotted Fever are spread by the black-legged tick, or deer tick. Dr. Murphy and Dr.Mead join "Sound Medicine" to discuss how humans and dogs contract tick-borne illnesses disease and how people can reduce their risk for these diseases..... (Source: Sound Medicine)


Saturday 26 April 2014

Needham Couple Pushes To Ban Morcellation For Fibroids

BOSTON (CBS) – Uterine fibroids are one of the most common health problems women face. The treatment options have usually been considered pretty routine. Now there are new concerns about a widely used procedure for fibroids known as morcellation. The fear is it can spread cancer. Amy Reed of Needham is now going through chemotherapy because she has stage 4 leimyosocarcoma. “It was very hard initially,” she said. “The level of anxiety is horrible.” It is not the outcome she expected to face after going into Brigham and Women’s Hospital last October to have fibroids removed. Instead of full abdominal surgery, Amy’s doctor used a morcellator, which is a minimally invasive approach. The tumors are shredded into pieces and extracted thru a small tube. As Amy went into the hosp...


Friday 25 April 2014

Implications of climate change on the distribution of the tick vector Ixodes scapularis and risk for Lyme disease in the Texas-Mexico transboundary region

Model for the current predicted distribution of I. scapularis in the transboundary region, was generated based on the collection of this tick species in different locations in both Texas and north-eastern Mexico. The presence of the bacterial pathogen B. burgdorferi, as well as the reservoir host Peromyscus leucopus, have also been described in this region. Image: Ixodes scapularis distribution in the Texas-Mexico transbounday region. (Source: Parasites and Vectors)


Friday 25 April 2014

Acute and chronic pain associated with Lyme borreliosis: Clinical characteristics and pathophysiologic mechanisms

Lyme disease is a multisystem disorder caused by several related borrelial subspecies referred to generally as Borrelia burgdorferi . It is transmitted by infected Ixodes ticks, and is the most common vector-borne infection occurring in endemic geographic areas in the temperate Northern hemisphere . In the United States, where reporting is mandatory, documented infection occurred in 50,000 persons between 1982 (when the etiologic agent was first identified) and 1994 . Since 1994, more than 500,000 new cases have been reported to the Centers for Disease Control and Prevention, averaging 20,000 to 30,000 cases per year . Many more cases are never reported to the Centers for Disease Control and Prevention , suggesting that millions of United States inhabitants have had symptomatic Lyme infect...

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Thursday 24 April 2014

FDA Proposes First Regulations For E-Cigarettes

WASHINGTON (AP) — The federal government wants to ban sales of electronic cigarettes to minors and require approval for new products and health warning labels. While the proposal being issued Thursday by the Food and Drug Administration won’t immediately mean changes for the popular devices, the move is aimed at eventually taming the fast-growing e-cigarette industry. The agency said the proposal sets a foundation for regulating the products but the rules don’t immediately ban the wide array of flavors of e-cigarettes, curb marketing on places like TV or set product standards. Any further rules “will have to be grounded in our growing body of knowledge and understanding about the use of e-cigarettes and their potential health risks or public health benefits,” FDA ...


Tuesday 22 April 2014

Electrochemotherapy as a novel treatment for primary cutaneous marginal zone B‐cell lymphomas

Abstract In the present study, we describe the use of electrochemotherapy as alternative therapy for primary cutaneous marginal zone B‐cell lymphomas in patients unsuitable for surgery or radiotherapy. Our experience refers to three patients with primary cutaneous marginal zone B‐cell lymphomas related to Borrelia burgdorferi infection, treated with specific antimicrobial therapy and electrochemotherapy. (Source: Dermatologic Therapy)


Tuesday 22 April 2014

Choosing Wisely: The American College of Rheumatology's Top 5 for Pediatric Rheumatology

ConclusionThe ACR pediatric rheumatology Top 5 is one of the first pediatric subspecialty–specific Choosing Wisely Top 5 lists and provides an opportunity for patients and providers to discuss appropriate use of health care in pediatric rheumatology. (Source: Arthritis Care and Research)


Monday 21 April 2014

RheumShorts: Methotrexate, Basiliximab, and Norwegian Lyme (CME/CE)

(MedPage Today) -- Subcutaneous methotrexate can be given at higher doses than in the oral route, while maintaining bioavailability, which could make for better tolerance and better adherence to treatment guidelines, a new study suggested. (Source: MedPage Today Geriatrics)


Monday 21 April 2014

The challenge of diagnosing Lyme disease

(Source: NaturalNews.com)

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Friday 18 April 2014

New CDC/FDA Warning Against Unapproved Lyme Culture TestNew CDC/FDA Warning Against Unapproved Lyme Culture Test

Investigators from the CDC and FDA have issued a new warning about the use of unvalidated Lyme disease tests, sparked by inquiries to the CDC about a test marketed by Advanced Laboratory Services. Medscape Medical News (Source: Medscape Infectious Diseases Headlines)


Friday 18 April 2014

Avoid New Lyme Culture Test, Say CDC and FDA

(MedPage Today) -- CDC and the FDA have again cautioned the public about the use of an unapproved test for diagnosing Lyme disease. (Source: MedPage Today Geriatrics)


Friday 18 April 2014

A phylogenomic and molecular marker based proposal for the division of the genus Borrelia into two genera: the emended genus Borrelia containing only the members of the relapsing fever Borrelia, and the genus Borreliella gen. nov. containing the members of the Lyme disease Borrelia (Borrelia burgdorferi sensu lato complex).

Authors: Adeolu M, Gupta RS Abstract The genus Borrelia contains two groups of organisms: the causative agents of Lyme disease and their relatives and the causative agents of relapsing fever and their relatives. These two groups are morphologically indistinguishable and are difficult to distinguish biochemically. In this work, we have carried out detailed comparative genomic analyses on protein sequences from 38 Borrelia genomes to identify molecular markers in the forms of conserved signature inserts/deletions (CSIs) that are specifically found in the Borrelia homologues, and conserved signature proteins (CSPs) which are uniquely present in Borrelia species. Our analyses have identified 31 CSIs and 82 CSPs that are uniquely shared by all sequenced Borrelia species, providing molec...

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Friday 18 April 2014

CDC Warns Against Use of Unapproved Lyme Disease Test (FREE)

By Cara Adler An unapproved test that uses a new culture method for Borrelia burgdorferi could misdiagnose Lyme disease, CDC and FDA researchers warn in MMWR.The test … (Source: Physician's First Watch current issue)


Friday 18 April 2014

Concerns Regarding a New Culture Method for Borrelia burgdorferi Not Approved for the Diagnosis of Lyme Disease.

Authors: Nelson C, Hojvat S, Johnson B, Petersen J, Schriefer M, Beard CB, Petersen L, Mead P, Division of Vector-Borne Diseases, National Center for Emerging and Zoonotic Infectious Diseases, CDC Abstract In 2005, CDC and the Food and Drug Administration (FDA) issued a warning regarding the use of Lyme disease tests whose accuracy and clinical usefulness have not been adequately established. Often these are laboratory-developed tests (also known as "home brew" tests) that are manufactured and used within a single laboratory and have not been cleared or approved by FDA. Recently, CDC has received inquiries regarding a laboratory-developed test that uses a novel culture method to identify Borrelia burgdorferi, the spirochete that causes Lyme disease. Patient specimens reportedly are...


Thursday 17 April 2014

Concerns Regarding a New Culture Method for Borrelia burgdorferi Not Approved for the Diagnosis of Lyme Disease

(Source: CDC Morbidity and Mortality Weekly Report)


Thursday 17 April 2014

Defensin from the ornate sheep tick Dermacentor marginatus and its effect on Lyme borreliosis spirochetes.

Authors: Chrudimská T, Ceřovský V, Slaninová J, Rego RO, Grubhoffer L Abstract Expression of the previously reported defensin of the tick Dermacentor marginatus (defDM) was analysed in different organs by RT-PCR. mRNA of the defDM gene was detected in the hemolymph, midgut and salivary glands. Moreover defDM was isolated from the tick hemolymph using RP-HPLC and its sequence was determined by mass spectrometry and Edman degradation. Synthetic peptide was used for determining biological activities. The results showed an anti-Gram-positive bacterial role for the defensin. As D. marginatus ticks appear not to be vectors of the Lyme disease agent of the complex Borrelia burgdorferi sensu lato, we tested the influence of defDM on Borrelia afzelii. There is a very clear borrelicidal ...


Wednesday 16 April 2014

Harvard Researchers: Feminine Girls, Masculine Boys Have Higher Cancer Risk

BOSTON (CBS) — Researchers at Harvard School of Public Health have found that very feminine girls and strongly masculine boys are more likely to engage in behaviors that pose cancer risks than their gender non-conforming peers. WBZ NewsRadio1030′s Diane Stern reports Feminine Girls, Masculine Boys And Cancer Risk BehaviorsWBZ NewsRadio 1030playpausejQuery(document).ready(function($) { cbs_audio_player_v2("audio-player-3"); }); Scientists analyzed data from over 9,000 adolescents. The study compared cancer risk behaviors to the participants’ gender expressions. The study found that the most feminine girls were more likely to use tanning beds and be physically inactive. The most masculine boys were more likely to use chewing tobacco and smoke cigars. “Our findings indica...


Wednesday 16 April 2014

Local Company Instrumental In First Regenerated Esophagus

BOSTON (CBS) —- A local company is part of a second breakthrough in regeneration of human body parts. A research team led by Paolo Macchiarin at Karolinska Institutet in Sweden has successfully transplanted a regenerated esophagus into a rat. The results were published in Nature Communications on Tuesday. WBZ NewsRadio 1030′s Diane Stern reports  WBZ NewsRadio 1030WBZ NewsRadio 1030playpausejQuery(document).ready(function($) { cbs_audio_player_v2("audio-player-4"); });   Harvard Apparatus Regenerative Technology developed the bio-reactor that was essential in creating the esophagus. Last year, the same company regenerated a human trachea and transplanted it into a human. HART CEO David Green says the study is promising as it represents advancements toward the translation of ...


Wednesday 16 April 2014

Immune System Research May Help Doctors Predict Who Gets Long-Term Complications From Lyme Disease - 4/16/14

A team of scientists led by Johns Hopkins and Stanford University researchers has laid the groundwork for understanding how variations in immune responses to Lyme disease can contribute to the many different outcomes of this bacterial infection seen in individual patients. (Source: Johns Hopkins Medicine News)

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Monday 14 April 2014

Adverse moisture events predict seasonal abundance of Lyme disease vector ticks (Ixodes scapularis)

Seasonal incidence of tick adverse moisture events can explain inter-annual variability seen in vector blacklegged tick (Ixodes scapularis) abundance, offering the possibility to more accurately predict human Lyme borreliosis incidence. Image: Nymphal blacklegged tick feeding (Courtesy Dr. Thomas Mather - Center for Vector-Borne Disease) . (Source: Parasites and Vectors)


Monday 14 April 2014

Seroprevalence of antibodies to Borrelia burgdorferi sensu lato in healthy adults from western Norway: risk factors and methodological aspects

In conclusion, antibodies to B. burgdorferi s.l. are common in blood donors in western Norway. The results may be used for evaluation of predictive values of test results in patients, as well as a basis for test algorithms in the laboratory. (Source: APMIS)


Sunday 13 April 2014

Prevent Tick Bites While Enjoying the Outdoors

With no vaccines for Lyme and other tick-borne diseases, expert explains how to avoid infection Source: HealthDay Related MedlinePlus Page: Tick Bites (Source: MedlinePlus Health News)


Saturday 12 April 2014

The British bug that could paralyse you

Literary agent Ed Victor (pictured) who represents Nigella Lawson contracted Lyme disease after a crimson 'bull's eye mark' appeared on his leg. (Source: the Mail online | Health)


Thursday 10 April 2014

Boston Reports Recent Spike In Flu Cases

BOSTON (CBS) – Flu season may appear to be over, but flu cases are on the rise again in Boston, city health officials said on Thursday. The Boston Public Health Commission reports that there were 116 newly reported cases of flu in Boston between March 30 and April 5. That brings this season’s total number of reported cases in the city to 1,237. More than 25 percent of these cases have resulted in hospitalization, and there have been 11 flu-related deaths. MORE HEALTH NEWS FROM CBS BOSTON Health Officials: MERS Patient Traveled Through BostonHarsh Winter Does Little To Ease Lyme Disease WoesDoctors: More Young People Developing OsteoporosisYale Researchers: New Tick-Borne Illness Common In Southern New England (Source: WBZ-TV - Breaking News, Weather and Sports...

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Wednesday 9 April 2014

Beth Israel Doctors Using Google Glass In ER

BOSTON (CBS) — Doctors at Beth Israel Deaconess Medical Center are the first in the country to be using Google Glass technology to save valuable seconds. Google introduced the Glass technology in 2013 and only a limited number of people have been able to try it. Beth Israel Deaconess is the first hospital in the world to use the high-tech classes for direct patient care. Dr. Steven Horng is an emergency room physician who spearheaded a program to bring the technology to the ER. What they do is project an image of the patient’s screens so information about the patient is obtained right away. Information like the patient’s name, their past medical history, even X-rays can all come up with Google Glass and could be life-saving, especially if a patient can’t communicat...


Wednesday 9 April 2014

Hyperacusis as the Initial Presentation of Creutzfeldt-Jakob Disease (P5.233)

CONCLUSIONS: We describe the first case of hyperacusis as the initial presenting complaint of CJD. This case highlights the wide spectrum of initial symptoms in patients with spongiform encephalopathy.Disclosure: Dr. Merkler has nothing to disclose. Dr. Safdieh has nothing to disclose. (Source: Neurology)


Wednesday 9 April 2014

When the Typical Becomes Atypical: Anti-Ri Antibody Associated Paraneoplastic Syndrome WITHOUT Opsoclonus-Myoclonus (P7.024)

OBJECTIVE: To illustrate a case of anti-Ri-associated paraneoplastic neurologic syndrome without its "classic" opsoclonus-myoclonus.BACKGROUND: Paraneoplastic neurologic syndromes cause significant morbidity and mortality. Its heterogeneous clinical presentations are underrecognized, delaying diagnosis and treatment.DESIGN/METHODS: A 64-year-old man noted fatigue, diplopia and left eyelid ptosis. Three months later he developed generalized weakness, dysarthria, dysphagia and respiratory failure. He had smoked cigarettes for 40 years. Examination demonstrated lethargy, tongue myoclonus, bilateral horizontal gaze palsy and ptosis. He had neck and proximal muscle weakness, significant left leg paresis and hyporreflexia, hyperactive reflexes elsewhere and bilateral Babinski sign. Sensory exami...


Wednesday 9 April 2014

A Case of Primary Meningeal Melanoma (P7.255)

CONCLUSIONS:Primary meningeal melanoma is a neoplasm of leptomeningeal melanocytes embryonically originating from the neural crest. Initial presentation can vary from nerve palsies, focal weakness, seizure and personality changes. This patient presented with seizure and abnormal brain imaging. Diagnosis was established on the basis of CSF analysis, brain biopsy and immunohistological studies.Study Supported by:Disclosure: Dr. Roy has nothing to disclose. Dr. Al Zahmi has nothing to disclose. Dr. Danialan has nothing to disclose. Dr. Mandavilli has nothing to disclose. (Source: Neurology)

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Wednesday 9 April 2014

Paraneoplastic Cerebellar Degeneration with Castleman Disease: A Case Report (P1.027)

CONCLUSIONS: Although a specific autoantibody was not identified, the rarity of both Castleman disease and cerebellar degeneration, in conjunction with the well-described neoplastic and paraneoplastic associations of both, strongly suggests a relationship not previously described.Disclosure: Dr. Lee has nothing to disclose. Dr. Le has nothing to disclose. (Source: Neurology)


Wednesday 9 April 2014

Diagnostic Dilemma Of Encephalomyelitis Due To Lyme Neuroborreliosis (P2.313)

CONCLUSIONS:Although reported in the literature, encephalomyelitis from lyme neuroborreliosis is rare. Identification of this disease can be difficult but early recognition and treatment with antibiotics leads to marked improvement, as demonstrated in our case.Study Supported by:n/aDisclosure: Dr. Stroup has nothing to disclose. Dr. Daudi has nothing to disclose. Dr. Patel has nothing to disclose. (Source: Neurology)


Wednesday 9 April 2014

An Unusual Case Of Idiopathic Intracranial Hypertension Presenting With Simultaneous IIIrd, VIth and V11th Nerve Palsies (P6.305)

CONCLUSIONS: CN palsies other than VIth nerve are an atypical presentation of IIH and are only described in case reports. Infectious (especially Lyme's), inflammatory (especially Sarcoid), rheumatologic and other auto immune causes must be ruled out. Treatment should be initiated promptly and offending agents should be discontinued to prevent permanent visual loss.Study Supported by: NoneDisclosure: Dr. Katyayan has nothing to disclose. Dr. Parachuri has nothing to disclose. Dr. Sallowm has nothing to disclose. Dr. Walsh has nothing to disclose. (Source: Neurology)


Wednesday 9 April 2014

Widespread Leptomeningeal Involvement in Borreliosis (P2.317)

CONCLUSIONS: We describe an atypical case of B. burgdorferi causing multiple cranial neuropathies associated with polyradiculitis. This case highlights the spectrum of neurological disease in Lyme disease.Study Supported by: N/ADisclosure: Dr. Maciel has nothing to disclose. Dr. Wang has nothing to disclose. Dr. Shirvalkar has nothing to disclose. Dr. Merkler has nothing to disclose. Dr. Safdieh has nothing to disclose. (Source: Neurology)


Wednesday 9 April 2014

Con-focal Microscopy Documents Significant Epidermal Nerve Demyelization in Patients With Clinical Neuropathy But Normal Neurophysiologic Studies (P7.107)

Discussion: Inflammatory neuropathies of small fibers are difficult to document . The ability to see demyelization of small myelinated fibers of the skin through con-focal microscopy will enable the proper diagnosis and treatment.Disclosure: Dr. Katz has received personal compensation for activities with Forest Laboratories, Inc. as a speaker. (Source: Neurology)


Wednesday 9 April 2014

Monoclonal B Cell Population in a Patient With Neurosarcoidosis (P5.175)

We present a case of transverse myelitis as the sole manifestation of sarcoidosis with a concomitant monoclonal B cell population identified in the CSF.A 48 year old male with past medical history of pulmonary embolism, insulin dependent Type 2 Diabetes, hypertension, and hyperlipidemia presented with six months of gait ataxia, difficulty urinating, and lower extremity paresthesias. Spinal MRI showed abnormal signal and enhancement throughout the cervical and thoracic cord. He was diagnosed with transverse myelitis and underwent extensive workup to identify the underlying etiology. No demyelinating lesions were seen on brain MRI. Lumbar puncture had normal cell counts and opening pressure with elevated protein and glucose (77mg/dL and 159mg/dL respectively). Hemoglobin A1C was 9.1%. Serum ...

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Tuesday 8 April 2014

Intermediate uveitis in children and young adults: differences in clinical course, associations and visual outcome.

CONCLUSIONS: IU with onset in childhood and early adulthood showed a similar visual course at intermediate follow-up. Associated diseases and complication patterns differed between children and young adults. PMID: 24713505 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)


Monday 7 April 2014

Africa: World Health Day - Stop Disease-Carrying Pests

[State Department]Washington -Mosquitoes, flies, ticks, water snails and other pests can carry diseases that sicken more than 1 billion people each year with malaria, dengue, leishmaniasis, Lyme disease, yellow fever and other dangerous conditions. Half the world -- 3.6 billion people -- live in areas where they risk exposure to what are known as vector-borne diseases. (Source: AllAfrica News: Health and Medicine)


Monday 7 April 2014

World Health Day 2014

It's World Health Day and the focus this year is on vector-borne diseases, or diseases that can be transmitted by the bite of mosquitoes, ticks, fleas, and water snails. Unfortunately, while the CDC states that "vector-borne diseases account for 17% of the estimated global burden of all infectious diseases," it is important to remember that there are no vaccines to help prevent most of them. These diseases include dengue, schistosomiasis, leishmaniasis, Lyme disease, West Nile virus, Rocky Mountain spotted fever, Chagas disease, and malaria, which remains "one of the most severe public health problems worldwide."...Read Full Post (Source: About.com Pediatrics)


Sunday 6 April 2014

Structural characterization of CspZ, a complement regulator factor H and FHL‐1 binding protein from Borrelia burgdorferi

This article is protected by copyright. All rights reserved. (Source: FEBS Journal)


Saturday 5 April 2014

Lyme arthritis in Southern Norway - an endemic area for Lyme Borreliosis

Conclusions: Our data shows that LA in Southern Norway is a benign disease which successfully can be treated with antibiotics even in patients treated with GC prior to antibiotics. (Source: BMC Infectious Diseases)

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Friday 4 April 2014

Seasonal Prevalence of Lyme Disease Spirochetes in a Heterothermic Mammal, the Edible Dormouse (Glis glis).

Authors: Fietz J, Tomiuk J, Matuschka FR, Richter D Abstract In Europe, dormice serve as competent reservoir hosts for particular genospecies of the tick-borne agent of Lyme disease (LD) and seem to support them more efficiently than do mice or voles. The longevity of edible dormice (Glis glis) and their attractiveness for ticks may result in a predominance of LD spirochetes in ticks questing in dormouse habitats. To investigate the role of edible dormice in the transmission cycle of LD spirochetes, we sampled skin tissue from the ear pinnae of dormice inhabiting five different study sites in south western Germany. Of 501 edible dormice, 12.6% harbored DNA of LD spirochetes. Edible dormice were infected most frequently with the pathogenic LD spirochete Borrelia afzelii. DNA of B. g...


Thursday 3 April 2014

The paradox of the binomial Ixodes ricinus activity and the observed unimodal Lyme borreliosis season in Hungary

(Source: International Journal of Environmental Health Research)


Thursday 3 April 2014

Evolutionary Genomics of Borrelia burgdorferi sensu lato: Findings, Hypotheses, and the Rise of Hybrids.

Authors: Qiu WG, Martin CL Abstract Borrelia burgdorferi sensu lato (B. burgdorferi s.l.), the group of bacterial species represented by Lyme Disease pathogens, has one of the most complex and variable genomic architectures among prokaryotes. Showing frequent recombination within and limited gene flow among geographic populations, the B. burgdorferi s.l. genomes provides an excellent window into the processes of bacterial evolution at both within- and between-population levels. Comparative analyses of B. burgdorferi s.l. genomes revealed a highly dynamic plasmid composition but a conservative gene repertoire. Gene duplication and loss as well as sequence variations at loci encoding surface-localized lipoproteins (e.g., the PF54 genes) are strongly associated with adaptive differenc...


Wednesday 2 April 2014

Harvard Study Raises Questions About Mammograms

BOSTON (CBS) –A recent study out of Harvard suggests that deciding when and how often to have a mammogram is not a black or white issue. Researchers looked at 50 years worth of data on the effectiveness of mammograms and concluded that the benefits of screening are often overstated and that the harms are often downplayed. They found mammograms decreased the risk of dying from breast cancer by only about 19-percent. The survival benefit was even less for women in their 40′s, but more for women in their 60′s, who are much more likely to get breast cancer. That said, among women in their 40′s and 50′s who get mammograms every year for 10 years, more than half of them will receive a false positive result. Mammograms involve small concentrated doses of radiation an...


Wednesday 2 April 2014

Strain-specific Lyme disease immunity lasts for years

Lyme disease, if not treated promptly with antibiotics, can become a lingering problem for those infected. But a new study led by researchers from the University of Pennsylvania has some brighter news: Once infected with a particular strain of the disease-causing bacteria, humans appear to develop immunity against that strain that can last six to nine years. (Source: ScienceDaily Headlines)

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Wednesday 2 April 2014

World Health Day 2014: Preventing vector-borne diseases

2 April 2014 -- More than half the world’s population is at risk from diseases such as malaria, dengue, leishmaniasis, Lyme disease, schistosomiasis, and yellow fever, carried by mosquitoes, flies, ticks, water snails and other vectors. Every year, more than 1 billion people are infected and more than 1 million die from vector-borne diseases. This World Health Day – 7 April – WHO is highlighting the serious and increasing threat of vector-borne diseases, with the slogan “Small bite, big threat”. (Source: WHO news)


Wednesday 2 April 2014

Strain-specific Lyme disease immunity lasts for years, Penn research finds

(University of Pennsylvania) A new study led by researchers from the University of Pennsylvania shows that humans appear to develop immunity against specific strains of the Lyme disease that can last six to nine years. (Source: EurekAlert! - Infectious and Emerging Diseases)


Wednesday 2 April 2014

Diversity of antibody responses to Borrelia burgdorferi in experimentally-infected beagle dogs.

Authors: Baum E, Grosenbaugh DA, Barbour AG Abstract Lyme borreliosis (LB) is a common infection of domestic dogs in areas where there is enzootic transmission of the agent Borrelia burgdorferi. While immunoassays based on individual subunits have mostly supplanted whole cell-based preparations for canine serology, only a limited number of informative antigens have been identified. To more broadly characterize the antibody responses to B. burgdorferi infection and to assess the diversity in those responses between individual dogs, we examined sera from 32 adult, colony-bred beagle dogs that were experimentally infected with B. burgdorferi through tick bites and compared those on a protein microarray with sera from uninfected dogs in their antibody reactivities to various recombinan...


Tuesday 1 April 2014

Exposure to Borrelia burgdorferi and Other Tick-Borne Pathogens in Gettysburg National Military Park, South-Central Pennsylvania, 2009

Vector-Borne and Zoonotic Diseases , Vol. 0, No. 0. (Source: Vector-Borne and Zoonotic Diseases)


Monday 31 March 2014

A Better Way To Test Blood Pressure

BOSTON (CBS) – Have you ever had your blood pressure checked in both arms at your doctor’s office? Researchers at Mass General Hospital say you probably should. A small difference between the two arms is normal. But a larger one could mean you’re at risk for heart disease. Dr. Ido Weinberg, a vascular medicine specialist, and colleagues at MGH, looked at data on nearly 3,400 local residents over the age of 40 enrolled in the Framingham heart study. “Patients who have that difference between arms could end up developing heart and blood vessel disease,” Dr. Weinberg said. Researchers found that people with a systolic blood pressure difference of 10 points or more between their arms were 38% more likely to develop a blood vessel disorder like a heart attack, stro...

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Monday 31 March 2014

[Lyme disease acrodermitis chronica atrophicans: Misleading vascular signs.]

We present a patient who exhibited an atypical clinical presentation of Lyme disease acrodermatitis chronic atrophicans. The clinical outcome was quite favorable with treatment, confirming the diagnosis. Such treatments, which are well tolerated and highly effective, are essential since an untreated disease can lead to potentially severe neurological involvement. PMID: 24698204 [PubMed - as supplied by publisher] (Source: Journal des Maladies Vasculaires)


Sunday 30 March 2014

[CXCL13: a biomarker for acute Lyme neuroborreliosis : Investigation of the predictive value in the clinical routine.]

CONCLUSIONS: The biomarker CXCL13 has a higher sensitivity (100 % vs. 87 %) with a specificity (99 %) comparable with the established diagnostic markers for LNB, e.g. CSF pleocytosis and Borrelia-AI in the investigated patient population. The negative predictive value of CXCL13 is 100 %. Therefore, a normal CXCL13 level virtually excludes LNB. In the clinical routine CXCL13 is a valuable and practical diagnostic marker for LNB and can even detect an acute LNB in patients without CSF pleocytosis. PMID: 24682168 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)


Saturday 29 March 2014

Oral doxycycline for Lyme neuroborreliosis with symptoms of encephalitis, myelitis, vasculitis or intracranial hypertension

ConclusionTreatment with oral doxycycline resulted in a similar decrease in CSF mononuclear cell counts in patients with Lyme neuroborreliosis with CNS symptoms compared with patients with Lyme neuroborreliosis with PNS symptoms. The results indicate that oral doxycycline is an effective treatment for Lyme neuroborreliosis irrespective of the severity of symptoms. (Source: European Journal of Neurology)


Thursday 27 March 2014

A82: Lyme Arthritis: an Emerging Clinical Problem in Nova Scotia, Canada

Conclusion:Increasing numbers of children with Lyme arthritis are being seen in the pediatric rheumatology clinic in Nova Scotia. LD was not considered as a diagnosis in the majority of cases by the referring physician. A quarter of patients also had a history of unrecognized neurologic manifestations of LD. In keeping with published North American reports, most patients had an excellent outcome however a proportion continued to have arthritis and disability following antibiotic therapy. (Source: Arthritis and Rheumatism)


Wednesday 26 March 2014

FDA Allows NH Girl To Try Controversial Brain Tumor Drug

MANCHESTER, N.H. (CBS) — McKenzie Lowe is looking great and feeling well. “Sometimes I have little headaches but they’re really little. They don’t bother me that much,” she says. And now comes news that the U.S. Food and Drug Administration has granted her wish to allow her to try a controversial drug her family believes could help cure her inoperable brain tumor. “Oh I started crying,” says the girl’s grandfather Frank LaFountain. But the good news was quickly tempered because there’s a new fight for the family. They have to find a doctor willing to administer the unapproved drug and so far, no luck. “We need a doctor is what we basically need right now,” said LaFountain. “Anywhere in the country doesn’t matter where. We’re going to ...

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Wednesday 26 March 2014

Mice are reservoirs for tick-borne pathogens, amplify risk of Lyme disease and other tick-borne ailments

People living in northern and central parts of the U.S. are more likely to contract Lyme disease and other tick-borne ailments when white-footed mice are abundant. Mice are effective at transferring disease-causing pathogens to feeding ticks. And, according to an in-press paper in the journal Ecology, these "super hosts" appear indifferent to larval tick infestations. (Source: Health News from Medical News Today)


Wednesday 26 March 2014

Comparison of serological and molecular panels for diagnosis of vector-borne diseases in dogs

Conclusions: We conclude that serological and PCR assays should be used in parallel to maximize CVBD diagnosis (Source: BioMed Central)


Tuesday 25 March 2014

‘Diabetes Day’ Stresses Importance Of Prevention

BOSTON (CBS) — The American Diabetes Association is encouraging all Americans to find out if they’re at risk for developing Type Two diabetes. Tuesday is national “Diabetes Day.” Dr. Jorge Plutzky, Director of the Vascular Prevention Program at Brigham and Women’s Hospital, says simple changes that make a world of difference when it comes to diabetes. WBZ NewsRadio 1030′s Diane Stern reports play pause Diabetes Day Stresses Importance Of Prevention Diane Stern Although there is evidence that childhood obesity is going down, Plutzky sa...


Tuesday 25 March 2014

Tips and tricks to stay safe from ticks

Jolyon Medlock, Medical Entomologist at Public Health England, explains why ticks are a health concern and outlines prevention tips for the public Related items from OnMedicaMosquitoes win battle of repellentEaster farm visit infection warningPublic warned to avoid tick bites and Lyme disease (Source: OnMedica Views)


Monday 24 March 2014

BIOTOX LYME (Phytolacca Decandra, Ehrlichia, Mycoplasma Pneumoniae, Borrelia Burgdorferi, Babesia Microti, Coxiella Burnetii, Chelidonium Majus, Herpes Zoster,) Liquid [The Wellness Center For Research And Education]

Updated Date: Mar 24, 2014 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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Monday 24 March 2014

Bacterial and protozoal agents of feline vector-borne diseases in domestic and stray cats from southern Portugal

Infections with Babesia vogeli, Bartonella clarridgeiae, Bartonella henselae, Borrelia burgdorferi sensu lato, Hepatozoon felis and Leishmania infantum were molecularly detected in domestic and stray cats from sourthern Portugal. Image: Male domestic cat from the region of Lisbon. (Source: Parasites and Vectors)


Monday 17 March 2014

People, Pets, and Parasites: One Health Surveillance in Southeastern Saskatchewan.

Authors: Schurer JM, Ndao M, Quewezance H, Elmore SA, Jenkins EJ Abstract Residents of remote and Indigenous communities might experience higher exposure to some zoonotic parasites than the general North American population. Human sero-surveillance conducted in two Saulteaux communities found 113 volunteers exposed as follows: Trichinella (2.7%), Toxocara canis (4.4%), Echinococcus (4.4%), and Toxoplasma gondii (1.8%). In dogs, 41% of 51 fecal samples were positive for at least one intestinal parasite, 3% of 77 were sero-positive for Borrelia burgdorferi, and 21% of 78 for T. gondii. Echinococcus exposure was more likely to occur in non-dog owners (odds ratio [OR]: 11.4, 95% confidence interval [CI]: 1.2-107, P = 0.03); although T. canis was more likely to occur in children (ages 4...


Saturday 15 March 2014

Identifying erythema migrans rash in patients with lyme disease.

Authors: Dardick K PMID: 24695559 [PubMed - in process] (Source: American Family Physician)


Wednesday 12 March 2014

Antibodies to endothelial cell growth factor and obliterative microvascular lesions in synovia of patients with antibiotic‐refractory Lyme arthritis

Conclusions. The correlations of ECGF autoantibody reactivity with obliterative microvascular lesions imply that these autoantibodies may be involved in the obliterative process, suggesting that anti‐ECGF antibodies have specific pathologic consequences in synovial tissue in patients with antibiotic‐refractory Lyme arthritis. © 2014 American College of Rheumatology. (Source: Arthritis and Rheumatism)


Wednesday 12 March 2014

Identification of OppA2 linear epitopes as serodiagnostic markers for Lyme disease.

Authors: Signorino G, Arnaboldi PM, Petzke MM, Dattwyler RJ Abstract Laboratory diagnosis of Lyme disease is based on the serological detection of antibodies against the etiologic agent, Borrelia burgdorferi. Current diagnostics are insensitive at detecting early infection, when treatment is most effective. This deficiency results from the limited number of B. burgdorferi antigens expressed in early infection, and the use of an insensitive two-tier paradigm, put in place to deal with insufficient specificity associated with the use of whole protein antigens and/or bacterial lysates as serodiagnostic targets. Whole protein antigens contain epitopes that are unique to B. burgdorferi as well as 'cross-reactive' epitopes found in other bacteria. One method for overcoming the limitation...

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Friday 7 March 2014

Lost first world war training battlefield discovered in Hampshire

Elaborate trench network was identified from old aerial photographs on land that is still owned by Ministry of DefenceA few suspiciously straight lines in a corner of a 1951 aerial photograph showing acres of featureless scrubby heath have led archaeologists to a lost first world war landscape.The mock battlefield, used for training soldiers before they were shipped across the Channel to confront the real thing, is complete with zig-zags of frontline, communication and reserve trenches, the enemy's front line, terrifyingly visible less than 200 yards away – and, a little further on, a holiday camp in Gosport, Hampshire.Browndown is still owned by the Ministry of Defence, but well used by local dog walkers, who knew there were humps, bumps and hollows into which a dog could annoyingly van...


Friday 7 March 2014

Identification of a core sequence for the binding of BosR to the rpoS promoter region in Borrelia burgdorferi.

Authors: Ouyang Z, Zhou J, Brautigam CA, Deka RK, Norgard MV Abstract The alternative sigma factor RpoS in Borrelia burgdorferi plays a central role in modulating host adaptive responses when spirochetes cycle between ticks and mammals. The transcriptional activation of σ54-dependent rpoS requires a Fur homologue designated as BosR. Previously, we found that BosR directly activates rpoS transcription by binding to the rpoS promoter. However, many other DNA-binding features of BosR have remained obscure. In particular, the precise DNA sequence targeted by BosR has not yet been completely elucidated. The prediction of a putative Per box within the rpoS promoter region has further confounded the identification of the BosR binding sequence. Herein, by using electrophoretic mobility sh...


Thursday 6 March 2014

Letter From the Editor: The Great Mimickers in Radiology

Many diseases have been referred to as “great imitator” or “great mimicker.” For the sake of accuracy, I looked up the definition in The Dictionary of Modern Medicine (JC. Segen, CRC Press; 1992): “The great imitator is a phrase used for medical conditions that feature nonspecific symptoms and may be confused with a number of other diseases. Most great imitators are systemic in nature.” The list of diseases referenced is pretty long and includes approximately 15 entities, among which are quite a few that we, radiologists, rarely encounter as the diseases do not exhibit abnormal imaging findings (e.g., Lyme disease or fibromyalgia). The list of “great imitators” for radiologists is quite different, as it is based on imaging findings and not on signs and symptoms. This issue ...



Wednesday 5 March 2014

Mouse vaccine could protect humans from Lyme disease

The only vaccine against tick-borne Lyme disease was pulled from the market because of side effects in humans. But could it still be useful?     (Source: New Scientist - Health)

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Wednesday 5 March 2014

Why are there several species of Borrelia burgdorferi sensu lato detected in dogs and humans?

Authors: Skotarczak B Abstract Borrelia burgdorferi sensu lato is a group of spirochete bacteria species some of which cause borreliosis in humans and dogs. Humans and dogs are susceptible to illness from many of the same tick-borne pathogens, including B. burgdorferi s.l. (Bbsl). Little is known about the pathogenic role of the species of Bbsl in canines. The molecular methods which detect and amplify the DNA of borreliae and allow the differentiation of borreliae species or strains have not been used in canine diagnostics yet. Until now, it has been believed that in European dogs, like in humans, at least three pathogenic species occur but the most frequently described symptoms may be associated with the infection caused by B. burgdorferi sensu stricto species. A dog as well as a...


Monday 3 March 2014

Tick Test for Persistent Lyme Disease Tried in HumansTick Test for Persistent Lyme Disease Tried in Humans

A small experiment to see whether uninfected ticks could "diagnose" a lingering Lyme infection in people produced modest results, researchers say. Reuters Health Information (Source: Medscape Medical News Headlines)


Saturday 1 March 2014

Borreliosis and synovial lesions

Lyme disease is a tick-borne disease caused by the spirohete Borrelia burgdorferi. In the northeastern United States where the disease is endemic, the main vectors are the hard ticks Ixodes scapularis and lxodes pacificus. (Source: Advances in Small Animal Medicine and Surgery)


Friday 28 February 2014

Tick test for persistent Lyme disease tried in humans

NEW YORK (Reuters Health) - A small experiment to see whether uninfected ticks could "diagnose" a lingering Lyme infection in people produced modest results, researchers say. (Source: Reuters: Health)


Tuesday 25 February 2014

Geographic and genospecies distribution of Borrelia burgdorferi sensu lato DNA detected in humans in the United States.

This study provides further evidence that B. burgdorferi sensu stricto is not the only species associated with signs and/or symptoms consistent with Lyme borreliosis in the USA. PMID: 24568883 [PubMed - as supplied by publisher] (Source: Journal of Medical Microbiology)

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Friday 21 February 2014

Outer Surface Proteins of Borrelia: Peerless Immune Evasion Tools.

Authors: Pulzova L, Bhide M Abstract Lyme borreliosis (LB), caused by Borrelia burgdorferi(B.b.), is the most frequently diagnosed tick-borne zoonosis in temperate zones of the Northern hemisphere. Borreliais unique among bacteria in its ability to express a wide variety of lipoproteins on its surface, which play an essential role in pathogenesis. Surface proteins of spirochetes are important virulence determinants, immune evasion molecules and adaptation factors in the transmission and interaction with host tissues. Vast diversity in the expressed surface proteome of Borreliain different niches and multifunctionality of proteins are the major strategies of Borreliato avoid the destructive effect of immune system. In this review we provide deep insight into the protein:protein inte...


Tuesday 18 February 2014

Ticks may cause double trouble, Stanford scientists find

(Stanford University) Stanford study finds ticks infected with Lyme disease and newly identified human pathogen are widespread in San Francisco Bay Area. (Source: EurekAlert! - Biology)


Friday 14 February 2014

To Stop Lyme, Vaccinate...the Mice?To Stop Lyme, Vaccinate...the Mice?

A new oral vaccine to prevent Lyme disease in mice decreased infection rates in ticks and might help break the cycle of transmission to humans. Medscape Medical News (Source: Medscape Infectious Diseases Headlines)


Friday 14 February 2014

Lymphocyte transformation test for diagnosis of Lyme borreliosis is currently not documented to be clinically useful

This article is protected by copyright. All rights reserved. (Source: Clinical Microbiology and Infection)


Friday 14 February 2014

Lack of IgG antibody seropositivity to Borrelia burgdorferi in patients with Parry–Romberg syndrome and linear morphea en coup de sabre in Mexico

ConclusionIn Mexico there are no previous studies on Borrelia infection and its relationship between PRS or LMCS. Our result showed a lack of association of either clinical entities with anti‐Borrelia‐antibodies. Former reports of this association may suggest coincidental findings without causal relationship. (Source: International Journal of Dermatology)

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Wednesday 12 February 2014

Test for persistent Lyme infection using live ticks shown safe in clinical study

(NIH/National Institute of Allergy and Infectious Diseases) In a first-of-its-kind study for Lyme disease, researchers have used live, disease-free ticks to see if Lyme disease bacteria can be detected in people who continue to experience symptoms such as fatigue or arthritis after completing antibiotic therapy. (Source: EurekAlert! - Infectious and Emerging Diseases)


Saturday 8 February 2014

Cannabis kicks Lyme disease to the curb

(Source: NaturalNews.com)


Thursday 6 February 2014

Mathematical Model Developed by UA Physicists Could Help Treat Lyme Disease

(Source: The University of Arizona: Health)


Wednesday 5 February 2014

Evaluation of the Borrelia burgdorferi BBA64 protein as a protective immunogen in mice.

Authors: Brandt KS, Patton TG, Allard AS, Caimano MJ, Radolf JD, Gilmore RD Abstract The Borrelia burgdorferi bba64 gene product is a surface localized lipoprotein synthesized within mammalian and tick hosts and is involved in vector transmission. These properties suggest that BBA64 may be a vaccine candidate against Lyme borreliosis. Protective immunity against B. burgdorferi challenge was assessed in mice immunized with BBA64 protein. Mice developed a high-titered antibody response following immunization with soluble recombinant BBA64, but were not protected when challenged by needle inoculation of culture-grown spirochetes. Likewise, mice passively immunized with an anti-BBA64 monoclonal antibody were not protected against needle-inoculated organisms. BBA64-immunized mice were s...


Tuesday 4 February 2014

Spatiotemporal evolution of erythema migrans, the hallmark rash of lyme disease.

Authors: Vig DK, Wolgemuth CW Abstract To elucidate pathogen-host interactions during early Lyme disease, we developed a mathematical model that explains the spatiotemporal dynamics of the characteristic first sign of the disease, a large (≥5-cm diameter) rash, known as an erythema migrans. The model predicts that the bacterial replication and dissemination rates are the primary factors controlling the speed that the rash spreads, whereas the rate that active macrophages are cleared from the dermis is the principle determinant of rash morphology. In addition, the model supports the clinical observations that antibiotic treatment quickly clears spirochetes from the dermis and that the rash appearance is not indicative of the efficacy of the treatment. The quantitative agreement be...

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Saturday 1 February 2014

Common questions about bell palsy.

Authors: Albers JR, Tamang S Abstract Bell palsy is an acute affliction of the facial nerve, resulting in sudden paralysis or weakness of the muscles on one side of the face. Testing patients with unilateral facial paralysis for diabetes mellitus or Lyme disease is not routinely recommended. Patients with Lyme disease typically present with additional manifestations, such as arthritis, rash, or facial swelling. Diabetes may be a comorbidity of Bell palsy, but testing is not needed in the absence of other indications, such as hypertension. In patients with atypical symptoms, magnetic resonance imaging with contrast enhancement can be used to rule out cranial mass effect and to add prognostic value. Steroids improve resolution of symptoms in patients with Bell palsy and remain the pr...


Tuesday 28 January 2014

Genotyping of borrelia from formalin‐fixed paraffin‐embedded skin biopsies of cutaneous borreliosis and tick bite reactions by assays targeting the IGS‐region, ospA, and OspC genes

ConclusionsOur results demonstrate that genotyping of borrelia can be easily implemented in a routine dermatopathology setting, especially useful as a fast method to confirm early cutaneous borreliosis. Genotyping could also enable earlier treatment of patients infected with invasive strains.This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)


Tuesday 28 January 2014

Genotyping of borrelia from formalin-fixed paraffin-embedded skin biopsies of cutaneous borreliosis and tick bite reactions by assays targeting the IGS-region, ospA, and OspC genes.

CONCLUSIONS: Our results demonstrate that genotyping of borrelia can be easily implemented in a routine dermatopathology setting, especially useful as a fast method to confirm early cutaneous borreliosis. Genotyping could also enable earlier treatment of patients infected with invasive strains. This article is protected by copyright. All rights reserved. PMID: 24471582 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)


Monday 27 January 2014

Meteorological Influences on the Seasonality of Lyme Disease in the United States.

Authors: Moore SM, Eisen RJ, Monaghan A, Mead P Abstract Lyme disease (Borrelia burgdorferi infection) is the most common vector-transmitted disease in the United States. The majority of human Lyme disease (LD) cases occur in the summer months, but the timing of the peak occurrence varies geographically and from year to year. We calculated the beginning, peak, end, and duration of the main LD season in 12 highly endemic states from 1992 to 2007 and then examined the association between the timing of these seasonal variables and several meteorological variables. An earlier beginning to the LD season was positively associated with higher cumulative growing degree days through Week 20, lower cumulative precipitation, a lower saturation deficit, and proximity to the Atlantic coast. The...


Saturday 25 January 2014

PCR Detection of Anaplasma phagocytophilum and Borrelia burgdorferi in Ixodes persulcatus Ticks in Mongolia.

Authors: Masuzawa T, Masuda S, Fukui T, Okamoto Y, Bataa J, Oikawa Y, Ishiguro F, Takada N Abstract A molecular epidemiological survey was conducted to identify the tick-borne disease agents Anaplasma phagocytophilum and Borrelia burgdorferi sensu lato in Selenge Province, Mongolia. The survey was in response to a suspected A. phagocytophilum infection in a patient. In 2012, a total of 129 questing Ixodes persulcatus adult ticks were sampled by flagging vegetation. A. phagocytophilum and Borrelia spp. were detected by PCR, targeting the 16S rDNA (rrs) and 5S-23S intergenic spacer region, respectively. Infection rates for A. phagocytophilum and B. burgdorferi sensu lato spp. were 6.2% and 55.0%, respectively. Six of the 129 ticks (4.9%) were coinfected with A. phagocytophilum and B....

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Thursday 23 January 2014

The Reply

The communications from DeLong et al and Fallon et al express concerns about the findings, implications, and methods used in the 4 published treatment trials for persistent symptoms in patients previously treated for Lyme disease. (Source: The American Journal of Medicine)


Thursday 23 January 2014

Potential Benefits of Retreatment Highlight the Need for Additional Lyme Disease Research

We are responding to Klempner et al regarding our statistical review of the National Institutes of Health–sponsored antibiotic retreatment trials for Lyme disease. Our primary finding is that the trials did not prove retreatment is ineffective. A basic concept in statistical science regarding randomized controlled trials is that one can only conclude treatment is ineffective when the treatment effect and confidence interval exclude and are below the minimum clinically important difference. None of the trials showed this. Two trials actually demonstrated evidence of improvement in patients with severe symptoms at baseline. The trials without significant findings did not incorporate interactions between treatment and baseline severity in their statistical analysis. The only valid conclu...


Thursday 23 January 2014

Ongoing Discussion About the US Clinical Lyme Trials

Although we agree with Klempner et al that results from post hoc analyses of randomized controlled trials need to be viewed with caution, we are concerned that important results from planned analyses of primary hypotheses are being disregarded. The key point is that the study by Krupp et al demonstrated efficacy of ceftriaxone with respect to placebo on the only primary outcome measure that could reasonably be considered valid. That 69% of patients benefited with improvement in fatigue from intravenous ceftriaxone at 6 months compared with 23% of patients given intravenous placebo is a clear demonstration of antibiotic efficacy (P  (Source: The American Journal of Medicine)


Wednesday 22 January 2014

BORRELIA REMEDY (Borrelia Burgdorferi,) Liquid [Apotheca Company]

Updated Date: Jan 22, 2014 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))


Monday 20 January 2014

Lyme Borreliosis Caused by Diverse Genospecies of Borrelia burgdorferi sensu lato in northeastern China

ConclusionIn northeastern China, three genospecies of LB patients were detected. The B. burgdorferi genospecies identified in this study was predominantly B. garinii. A case infected with B. valaisiana‐related genospecies was first reported.This article is protected by copyright. All rights reserved. (Source: Clinical Microbiology and Infection)

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Wednesday 15 January 2014

Gut Microbiota of the Tick Vector Ixodes scapularis Modulate Colonization of the Lyme Disease Spirochete.

Authors: Narasimhan S, Rajeevan N, Liu L, Zhao YO, Heisig J, Pan J, Eppler-Epstein R, Deponte K, Fish D, Fikrig E Abstract Arthopods such as Ixodes scapularis ticks serve as vectors for many human pathogens. The arthropod gut presents a pivotal microbial entry point and determines pathogen colonization and survival. We show that the gut microbiota of I. scapularis, a major vector of the Lyme disease spirochete Borrelia burgdorferi, influence spirochete colonization of ticks. Perturbing the gut microbiota of larval ticks reduced Borrelia colonization, and dysbiosed larvae displayed decreased expression of the transcription factor signal transducer and activator of transcription (STAT). Diminished STAT expression corresponded to lower expression of peritrophin, a key glycoprotein sc...


Tuesday 14 January 2014

Insights into the Biology of Borrelia burgdorferi Gained Through the Application of Molecular Genetics.

Authors: Groshong AM, Blevins JS Abstract Borrelia burgdorferi, the vector-borne bacterium that causes Lyme disease, was first identified in 1982. It is known that much of the pathology associated with Lyme borreliosis is due to the spirochete's ability to infect, colonize, disseminate, and survive within the vertebrate host. Early studies aimed at defining the biological contributions of individual genes during infection and transmission were hindered by the lack of adequate tools and techniques for molecular genetic analysis of the spirochete. The development of genetic manipulation techniques, paired with elucidation and annotation of the B. burgdorferi genome sequence, has led to major advancements in our understanding of the virulence factors and the molecular events associate...


Monday 13 January 2014

Recognizing Lyme CarditisRecognizing Lyme Carditis

Three recent cases of sudden cardiac death from Lyme carditis point to the importance of recognizing and promptly treating this complication of Lyme disease. CDC Expert Commentary (Source: Medscape Pediatrics Headlines)


Saturday 11 January 2014

Diagnostic Criteria of Acute Rheumatic Fever.

Authors: Burke RJ, Chang C Abstract Acute rheumatic fever is an inflammatory sequelae of Group A Streptococcal pharyngitis that affects multiple organ systems. The incidence of acute rheumatic fever has been declining even before the use of antibiotics became widespread, however the disease remains a significant cause of morbidity and mortality in children, particularly in developing countries and has been estimated to affect 19 per 100,000 children worldwide. Acute rheumatic fever is a clinical diagnosis, and therefore subject to the judgment of the clinician. Because of the variable presentation, the Jones criteria were first developed in 1944 to aid clinicians in the diagnosis of acute rheumatic fever. The Jones criteria have been modified throughout the years, most recently in ...


Thursday 2 January 2014

Divergence of Borrelia burgdorferi sensu lato spirochetes could be driven by the host: diversity of Borrelia strains isolated from ticks feeding on a single bird

Dispersal of infected ticks due to bird migration is a key to the establishment of new foci of Lyme borreliosis. The dynamics of infection in birds support the mixing of different species, the horizontal exchange of genetic information, and appearance of recombinant genotypes. Image: Genetically diverse Borrelia strains are often found within the same tick or same vertebrate host, presenting a wide opportunity for genetic exchange. (Source: BioMed Central)

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Monday 30 December 2013

A mathematical perspective of seasonal variations in Lyme disease transmission

Lyme disease is a common tick-borne illness caused by a bacterium, which is transmitted to humans through the bite of infected ticks. The transmission dynamics of Lyme disease is dependent on a variety of factors, including the length of the tick's life cycle, availability of hosts, climatic conditions and seasonal influences, which are important to understand for control strategies. (Source: Health News from Medical News Today)


Monday 30 December 2013

Ménage à trois: Borrelia, dendritic cells, and tick saliva interactions.

Authors: Mason LM, Veerman CC, Geijtenbeek TB, Hovius JW Abstract Borrelia burgdorferi sensu lato, the causative agent of Lyme borreliosis, is inoculated into the skin during an Ixodes tick bite where it is recognised and captured by dendritic cells (DCs). However, considering the propensity of Borrelia to disseminate, it would appear that DCs fall short in mounting a robust immune response against it. Many aspects of the DC-driven immune response to Borrelia have been examined. Recently, components of tick saliva have been identified that sabotage DC responses and aid Borrelia infection. In this review, we summarise what is currently known about the immune response of DCs to Borrelia and explore the mechanisms by which Borrelia manages to circumvent this immune response, with or w...


Sunday 29 December 2013

Occurrence and transmission efficiencies of Borrelia burgdorferi ospC types in avian and mammalian wildlife.

Authors: Vuong HB, Canham CD, Fonseca DM, Brisson D, Morin PJ, Smouse PE, Ostfeld RS Abstract Borrelia burgdorferi s.s., the bacterium that causes Lyme disease in North America, circulates among a suite of vertebrate hosts and their tick vector. The bacterium can be differentiated at the outer surface protein C (ospC) locus into 25 genotypes. Wildlife hosts can be infected with a suite of ospC types but knowledge on the transmission efficiencies of these naturally infected hosts to ticks is still lacking. To evaluate the occupancy and detection of ospC types in wildlife hosts, we adapted a likelihood-based species patch occupancy model to test for the occurrence probabilities (ψ - "occupancy") and transmission efficiencies (ε - "detection") of each ospC type. We detected differen...


Saturday 28 December 2013

On the Curious Motions of Syphilis and Lyme Disease Bacteria

The bacteria that cause syphilis and Lyme Disease have something extraordinary in common: they manage to propel themselves through their environment in spite of the fact their tails are located inside their bodies.For bacteria, they’re also unusually shaped and active. In this movie, you can see the bacteria that cause Lyme Disease moving like living, squirming cavatappi . [More] (Source: Scientific American - Official RSS Feed)


Monday 23 December 2013

Lyme borreliosis

Abstract: Lyme borreliosis is a tick-transmitted spirochaetal disease caused by Borrelia burgdorferi sensu lato. It is acquired in forested and heathland areas of the temperate northern hemisphere. The most common presentation is an erythematous rash spreading slowly from the site of a tick bite. Clinical manifestations of disseminated infection include facial palsy, viral-like meningitis, radiculopathy, meningoencephalitis and arthritis. Lyme borreliosis responds to antibiotic treatment at all stages, with excellent results for patients with early disease. Patients with long-standing infection causing significant tissue damage can have slow or incomplete recovery. A small minority of treated patients can have persistent non-specific symptoms, similar to those seen following some other inf...

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Saturday 21 December 2013

Dietary composition and spatial patterns of polar bear foraging on land in western Hudson Bay

Conclusions: Our results suggest that polar bears are foraging opportunistically in a manner consistent with maximizing intake while minimizing energy expenditure associated with movement. The frequent mixing of plant-based carbohydrate and animal-based protein could suggest use of a strategy that other Ursids employ to maximize weight gain. Further, consuming high rates of certain vegetation and land-based animals that may yield immediate energetic gains could, instead, provide other benefits such as fulfilling vitamin/mineral requirements, diluting toxins and assessing new foods for potential switching. (Source: BMC Ecology - Latest articles)


Friday 20 December 2013

Sensitive multiplex PCR assay to differentiate Lyme spirochetes and emerging pathogens Anaplasma phagocytophilum and Babesia microti

Conclusion: Real-time quantitative PCR using specific primers and molecular beacon probes for the selected amplicon described in this study can detect three tick-borne pathogens simultaneously in an accurate manner. (Source: BMC Microbiology - Latest articles)


Friday 20 December 2013

Assessment of the potential contribution of the highly conserved C‐terminal motif (C10) of Borrelia burgdorferi outer surface protein C (OspC) in transmission and infectivity

This article is protected by copyright. All rights reserved. (Source: FEMS Immunology and Medical Microbiology)


Thursday 19 December 2013

A mathematical perspective of seasonal variations in Lyme disease transmission

(Society for Industrial and Applied Mathematics) Lyme disease is a common tick-borne illness caused by a bacterium, which is transmitted to humans through the bite of infected ticks. In a paper published last month in the SIAM Journal on Applied Mathematics, authors Yuxiang Zhang and Xiao-Qiang Zhao propose a reaction-diffusion model to study transmission dynamics of Lyme disease while taking into account seasonality. (Source: EurekAlert! - Medicine and Health)


Thursday 19 December 2013

Essential factor for Lyme disease transmission identified

(Public Library of Science) Borrelia burgdorferi, the bacterium that causes Lyme disease, hitchhikes in ticks for dissemination to mammalian hosts--including humans. An article in the 19 Dec. issue of PLOS Pathogens identifies HrpA, an RNA helicase, as a crucial player in the transmission from ticks to mammals. George Chaconas and colleagues analyze the molecular function of the HrpA protein and further explore its role in the bacterium's complicated life cycle, in particular for transmission of the pathogen. (Source: EurekAlert! - Infectious and Emerging Diseases)

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Thursday 19 December 2013

Occupational exposure to zoonotic agents among agricultural workers in Lombardy Region, northern Italy.

Conclusions: The higher frequency of the presence of serum antibodies to zoonotic agents (e.g. Leptospira spp. and Coxiella burnetii) in animal breeders suggests that they are more exposed to biological agents than workers not involved in animal breeding activities. The risk of contact with HEV deserves further studies because the adoption of different assays can result in significantly different results. The promotion of immunization of agricultural workers might be a priority, in particular for migrants. PMID: 24364433 [PubMed - in process] (Source: Annals of Agricultural and Environmental Medicine : AAEM)


Tuesday 17 December 2013

Lysosomal β-glucuronidase regulates Lyme and rheumatoid arthritis severity

Lyme disease, caused by the spirochete Borrelia burgdorferi, is the most prevalent arthropod-borne illness in the United States and remains a clinical and social challenge. The spectrum of disease severity among infected patients suggests that host genetics contribute to pathogenic outcomes, particularly in patients who develop arthritis. Using a forward genetics approach, we identified the lysosomal enzyme β-glucuronidase (GUSB), a member of a large family of coregulated lysosomal enzymes, as a key regulator of Lyme-associated arthritis severity. Severely arthritic C3H mice possessed a naturally occurring hypomorphic allele, Gusbh. C57BL/6 mice congenic for the C3H Gusb allele were prone to increased Lyme-associated arthritis severity. Radiation chimera experiments revealed that resident...


Tuesday 17 December 2013

[Correspondence] Lyme disease vaccination: safety first – Author's reply

I wholly concur with Raphael Stricker and Lorraine Johnson that attention to safety must be central to the development of any novel therapeutic agent. Comparative safety has certainly been an open topic of discussion with several second generation vaccines, such as those for acellular pertussis, rotavirus, and Japanese encephalitis, which were developed mainly because of safety concerns with their predecessors. This should no doubt be the case for novel Lyme disease vaccines, whether based on Borrelia burgdorferi outer surface protein A (OspA) or other antigens. (Source: The Lancet Infectious Diseases)

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Tuesday 17 December 2013

[Correspondence] Lyme disease vaccination: safety first – Authors' reply

We refute the assertion by Raphael Stricker and Lorraine Johnson that we avoided discussion of the side-effects of the previously licensed Lyme vaccine, LYMErix, in our report of a novel multivalent candidate vaccine against Lyme borreliosis. In our introduction, we provide a full and balanced description of the hypothesised safety concerns associated with the monovalent outer surface protein A (OspA) vaccine LYMErix, and we present and discuss in detail the safety data generated in our phase 1/2 trial of the new multivalent vaccine. (Source: The Lancet Infectious Diseases)


Tuesday 17 December 2013

[Correspondence] Lyme disease vaccination: safety first

In the Article by Nina Wressnigg and colleagues and the related Comment by Paul Lantos describing a novel Lyme vaccine, the authors attempt to avoid discussion of the side-effects of the previous Lyme vaccine, LYMErix (SmithKline Beecham, Pittsburgh, USA). This approach to safety issues bodes ill for the new Lyme vaccine candidate. (Source: The Lancet Infectious Diseases)


Sunday 15 December 2013

Are Your Fibromyalgia Symptoms Due to Lyme Disease?

Lyme disease is the number one vector borne spreading epidemic worldwide, and mimics common diseases such as Fibromyalgia (FM), Chronic Fatigue Syndrome (myalgic encephalomyelitis), autoimmune diseases like rheumatoid arthritis and MS, as well as psychiatric conditions such as depression and anxiety.read more (Source: Psychology Today Depression Center)


Sunday 15 December 2013

Arthropod bites.

Authors: Juckett G Abstract The phylum Arthropoda includes arachnids and insects. Although their bites typically cause only local reactions, some species are venomous or transmit disease. The two medically important spiders in the United States are widow spiders (Latrodectus), the bite of which causes intense muscle spasms, and the brown recluse (Loxosceles), which may cause skin necrosis. Widow bites usually respond to narcotics, benzodiazepines, or, when necessary, antivenom. Most recluse bites resolve uneventfully without aggressive therapy and require only wound care and minor debridement. Tick bites can transmit diseases only after prolonged attachment to the host. Treatment of clothing with permethrin and proper tick removal greatly reduce the risk of infection. Ticks of medi...


Friday 13 December 2013

Three Sudden Cardiac Deaths Associated with Lyme Carditis — United States, November 2012–July 2013

(Source: CDC Morbidity and Mortality Weekly Report)


Friday 13 December 2013

Three Cases of Sudden Cardiac Death Linked to Lyme Carditis (FREE)

By Cara Adler Three cases of sudden cardiac death associated with Lyme carditis were reported in 2012 and 2013 and are described in MMWR … (Source: Physician's First Watch current issue)


Friday 13 December 2013

Three sudden cardiac deaths associated with lyme carditis - United States, november 2012-july 2013.

Authors: Centers for Disease Control and Prevention (CDC) Abstract Lyme disease is a multisystem illness caused by Borrelia burgdorferi, a spirochete transmitted by certain species of Ixodes ticks. Approximately 30,000 confirmed and probable cases of Lyme disease were reported in the United States in 2012, primarily from high-incidence states in the Northeast (Connecticut, Delaware, Maine, Maryland, Massachusetts, New Hampshire, New Jersey, New York, Pennsylvania, Rhode Island, and Vermont) and upper Midwest (Minnesota and Wisconsin). Common manifestations include cutaneous, neurologic, and rheumatologic signs and symptoms. Symptomatic infection of the heart is rare in recognized Lyme disease cases and usually resolves promptly with appropriate antibiotic therapy. Nonetheless, card...

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Thursday 12 December 2013

Sudden Cardiac Death in Untreated Lyme CarditisSudden Cardiac Death in Untreated Lyme Carditis

Three sudden cardiac deaths associated with undiagnosed and untreated Lyme carditis highlighted the need to check cardiac status in patients with Lyme disease and Lyme exposure in some heart patients. Medscape Medical News (Source: Medscape Today Headlines)


Wednesday 11 December 2013

Lyme disease in the United Kingdom

Lyme disease, while still an uncommon disease in the UK, is on the increase. Case numbers have increased by 3.6-fold since 2001, with over 950 cases reported by the Health Protection Agency (HPA) in 2011, compared with less than 500 cases annually pre-2004. HPA indications of the true incidence are suggested to be closer to 3000 cases/year, of which around 82% of cases are indigenously acquired. Three genospecies, Borrelia burgdorferi sensu stricto, Borrelia afzelli and Borrelia garinii, represent the predominant pathogenic variants in the UK. Erythema migrans is the commonest manifestation, occurring in 60%–91% of cases. In the UK, neuroborelliosis is the most common complication, while myocarditis is unusual, and death from either conduction disease or carditis is extremely rare. T...


Tuesday 10 December 2013

Co-infection of Borrelia burgdorferi sensu lato and Rickettsia species in ticks and in an erythema migrans patient

The co-infection rates with Rickettsia spp. and B. burgdorferi s.l. in ticks and in patients with early Lyme borreliosis were determined. Image: Ixodes ricinus can carry Borrelia and Rickettsia simultaneously. (Source: Parasites and Vectors)


Monday 9 December 2013

Determinants and protective behaviours regarding tick bites among school children in the Netherlands: a cross-sectional study

Conclusions: Most children have a good knowledge of ticks and the potential consequences of tick bites. Knowing persons who personally got ill after tick-bite is associated with a good knowledge score and leads to higher susceptibility and better appreciation of the need for body checks. Perceived severity is associated with a good knowledge score and with knowing persons who got ill after tick-bite. Is seems to be useful to additionally address children in health education regarding ticks and tick-borne diseases. The relationship between health education programs for children (and their parents) about ticks and their possible consequences and prevention of these deserves further study. (Source: BMC Public Health - Latest articles)


Friday 6 December 2013

Crystal structure of PfbA, a surface adhesin of Streptococcus pneumoniae, provides hints into its interaction with fibronectin.

Authors: Beulin DS, Yamaguchi M, Kawabata S, Ponnuraj K Abstract PfbA is a surface adhesin and invasin of Streptococcus pneumoniae that binds to human fibronectin and plasminogen of the host extracellular matrix. It is a virulence factor for its pathogenesis. The crystal structure of recombinant PfbA150-607 from S. pneumoniae strain R6, was determined using multiwavelength anomalous dispersion (MAD) method and refined to 1.90Å resolution. The structure of rPfbA150-607 revealed that residues Thr150 to Lys570 form a rigid parallel beta helix, followed by a short disordered region (571 to 607) that consists of beta hairpins. The structural organization of the beta helix resembles that of polysaccharide-modifying enzymes. The structural and sequence features essential for fibronectin...

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Thursday 5 December 2013

The telomere resolvase of the Lyme disease spirochete, Borrelia burgdorferi, promotes DNA single-strand annealing and strand exchange

We report here that ResT also possesses single-strand annealing activity and a limited ability to promote DNA strand exchange reactions on partial duplex substrates. This combination of activities suggests ResT is a nexus between the seemingly distinct processes of telomere resolution and homologous recombination. Implications for hairpin telomere replication and linear plasmid recombination, including antigenic variation, are discussed. (Source: Nucleic Acids Research)


Wednesday 4 December 2013

Sensitivity of a point of care tick-test for the development of Lyme borreliosis

We evaluated whether a self-test for ticks predicts development of early Lyme borreliosis. We used www.tekenradar.nl for collection of ticks removed from humans, and subsequent follow-up. The self-test appeared to be not suitable for the prediction of early Lyme borreliosis. Image: Adult and nymphal Ixodes ricinus together with the logo of the website. (Source: Parasites and Vectors)


Sunday 1 December 2013

Global infectious diseases—The new norm for the United States?

From 1900 to the end of the 20th century, and into the present, there has been a significant shift in the top ten causes of death in the United States (). Where once infectious diseases were leading health care concerns, these have been largely replaced by cardiovascular disease and cancer. Unfortunately for a large proportion of the planet, infectious diseases remain the leading causes of death, disability, in some cases preventable blindness, and other serious sequelae. Because of our location, significant public health and medical infrastructure, and widespread immunizations against a wide array of pathogens, the US has been fortunately isolated from many infectious diseases, with the notable exception of tuberculosis (TB), HIV/AIDS, Lyme, West Nile, pneumonia, and influenza-related ill...


Saturday 30 November 2013

Are My Anxiety and Depression Due to Lyme Disease?

Lyme disease is known as “the great imitator” and is spreading worldwide in epidemic proportions, mimicking every known medical condition seen in a doctor’s office. read more (Source: Psychology Today Anxiety Center)


Saturday 30 November 2013

Potential Role of Deer Tick Virus in Powassan Encephalitis Cases in Lyme Disease-endemic Areas of New York, USA.

We report 14 cases of Powassan encephalitis from New York during 2004-2012. Ten (72%) of the patients were residents of the Lower Hudson Valley, a Lyme disease-endemic area in which I. scapularis ticks account for most human tick bites. This finding suggests that many of these cases were caused by DTV rather than POWV. In 2 patients, DTV infection was confirmed by genetic sequencing. As molecular testing becomes increasingly available, more cases of Powassan encephalitis may be determined to be attributable to the DTV lineage. PMID: 24274334 [PubMed - in process] (Source: Emerging Infectious Diseases)

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Wednesday 27 November 2013

Etiology, diagnosis, and management of facial palsy: 2000 patients at a facial nerve center

Conclusion: Bell's palsy remains the most common facial palsy; females present more often for evaluation. Comprehensive diagnostic investigation is mandatory in atypical cases, and thorough management must be multi‐disciplinary. The algorithms presented herein outline a single center's approach to the facial palsy patient, providing a framework which clinicians caring for these patients may adapt to their specific settings. (Source: The Laryngoscope)


Friday 22 November 2013

Automated cerebrospinal fluid cell count - New reference ranges and evaluation of its clinical use in central nervous system infections.

CONCLUSIONS: We suggest new CSF cell count reference ranges of <4cells/μL for lymphocytes, <3cells/μL for monocytes and <3cells/μL for granulocytes. The separation of mononuclear cells into lymphocytes and monocytes did not facilitate the discrimination between Lyme neuroborreliosis and viral CNS infection. PMID: 24275252 [PubMed - as supplied by publisher] (Source: Clinical Biochemistry)


Tuesday 19 November 2013

Lyme neuroborreliosis presenting with alexithymia and suicide attempts - Banerjee R, Liu JJ, Minhas HM.

[Abstract unavailable] Language: Eng... (Source: SafetyLit: All (Unduplicated))


Tuesday 19 November 2013

New findings could help target the bacteria that cause Lyme disease and syphilis

(Cell Press) The bacterial pathogens that cause Lyme disease and syphilis are highly invasive. These pathogens, or spirochetes, can invade the central nervous system and, in the case of syphilis, enter the placenta, causing disease in the unborn child. In the Biophysical Journal, a Cell Press publication, researchers provide new insights into how these spirochetes penetrate tissue barriers. The findings might be used to develop new treatment strategies to help affected patients or even prevent infections. (Source: EurekAlert! - Infectious and Emerging Diseases)


Tuesday 19 November 2013

Viscous dynamics of lyme disease and syphilis spirochetes reveal flagellar torque and drag.

Authors: Harman M, Vig DK, Radolf JD, Wolgemuth CW Abstract The spirochetes that cause Lyme disease (Borrelia burgdorferi) and syphilis (Treponema pallidum) swim through viscous fluids, such as blood and interstitial fluid, by undulating their bodies as traveling, planar waves. These undulations are driven by rotation of the flagella within the periplasmic space, the narrow (∼20-40 nm in width) compartment between the inner and outer membranes. We show here that the swimming speeds of B. burgdorferi and T. pallidum decrease with increases in viscosity of the external aqueous milieu, even though the flagella are entirely intracellular. We then use mathematical modeling to show that the measured changes in speed are consistent with the exertion of constant torque by the spiroche...

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Wednesday 13 November 2013

Rituximab for tumefactive demyelination refractory to corticosteroids and plasma exchange

Case history A 38-year-old woman with no significant past medical history presented with a generalised tonic–clonic seizure. The patient was afebrile and general physical and neurological examinations were normal. MRI of the brain revealed an irregular mass in the right temporal lobe with T2-weighted and fluid-attenuated inversion recovery (FLAIR) signal hyperintensity and heterogeneous enhancement after the administration of gadolinium (figure 1A–D). Laboratory investigations included normal blood count, liver enzymes, serum creatinine, angiotensin converting enzyme and erythrocyte sedimentation rate (ESR). Serum serologies for lyme, syphilis, viral hepatitis, brucella and HIV were negative. Tests for antinuclear antibodies, extractable nuclear antigens, rheumatoid factor and ...


Thursday 7 November 2013

Natural killer cells and natural killer T Cells in Lyme arthritis

IntroductionNatural killer (NK) and natural killer T (NKT) cells provide a first line of defense against infection. However, these cells have not yet been examined in patients with Lyme arthritis, a late disease manifestation. Lyme arthritis usually resolves with antibiotic treatment. However, some patients have persistent arthritis after spirochetal killing, which may result from excessive inflammation, immune dysregulation and infection-induced autoimmunity. Methods: We determined the frequencies and phenotypes of NK cells and invariant NKT (iNKT) cells in paired peripheral blood (PB) and synovial fluid (SF) samples from 8 patients with antibiotic-responsive arthritis and 15 patients with antibiotic-refractory arthritis using flow cytometry and cytokine analyses. Results: In antibiotic-r...


Friday 1 November 2013

Differential expression of Ixodes ricinus salivary gland proteins in the presence of the Borrelia burgdorferi sensu lato complex.

Authors: Cotté V, Sabatier L, Schnell G, Carmi-Leroy A, Rousselle JC, Arsène-Ploetze F, Malandrin L, Sertour N, Namane A, Ferquel E, Choumet V Abstract In Europe, Ixodes ricinus is the main vector of Lyme borreliosis. Their salivary glands play a critical role in the biological success of ticks. To better understand the cross-talk between Borrelia burgdorferi and tick salivary glands, we analyzed protein expression in the salivary glands of Ixodes ricinus adult ticks that were infected by various strains of the B. burgdorferi sl complex. iTRAQ allowed the identification of more than 120 proteins, providing the first proteomic data pertaining to Ixodes ricinus salivary glands. Among these proteins, only 12 were modulated in the presence of various Borrelia strains. Most of them ar...


Friday 1 November 2013

Comparison of isolation rate of Borrelia burgdorferi sensu lato in two different culture media, MKP and BSK‐H

This article is protected by copyright. All rights reserved. (Source: Clinical Microbiology and Infection)


Wednesday 30 October 2013

Purification of a serine protease and evidence for a protein C activator from the saliva of the tick, Ixodes scapularis.

In this study, we have purified an enzyme with trypsin-like activity from the saliva of the tick vector of Lyme Disease, Ixodes scapularis. This enzyme, named as IXOSP (Ixodes scapularis salivary serine protease), is a 29.9 kDa molecule with N-terminus FPxMVxLRIKxR. A BLAST search identified IXOSP as a secreted serine protease (AAY66740) with a conserved catalytic triad His, Asp, and Ser. In vitro studies demonstrated that IXOSP cleaves chromogenic substrates with arginine in the P1 position, by a mechanism inhibited by PMSF or aprotinin. Gene expression studies revealed that IXOSP is expressed at different tick developmental stages, including eggs, and unfed or fed adult tick salivary glands, but not in nymphs or in the midgut. While the physiological substrate for IXOSP remains to be ide...

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Sunday 27 October 2013

Researchers Seek Scapegoat for Lyme Disease s Startling Prevalence

The fear of ticks, and of the Lyme disease these bloodsuckers carry, is well founded: roughly 30,000 cases of Lyme are reported to the U.S. Centers for Disease Control and Prevention every year. Because most cases go unreported, the true toll is more like 300,000, the CDC estimated in August. The new figure “confirms that Lyme disease is a tremendous public health problem,” Paul Mead, the CDC's chief of Lyme epidemiology and surveillance, said at the time. [More] (Source: Scientific American - Official RSS Feed)


Monday 21 October 2013

Recurrent Lyme Disease: Old or New Infection?Recurrent Lyme Disease: Old or New Infection?

A teen presents with a second bull's-eye rash. What is going on? Medscape Pediatrics (Source: Medscape Today Headlines)


Sunday 13 October 2013

Climate change: a survivors' guide

As warnings of global climate change grow ever more dire, John Vidal offers 10 tips on how to prepare for an apocalyptic future1 Stay cool, dryBritain is expected to get more extremes of heat and rainfall, so prepare for more severe floods, longer droughts and more powerful storms. No one knows quite what the effect over time will be of a slowing Gulf stream, or the melting of arctic sea ice, but climate scientists confidently expect temperatures to rise up to 4C by 2100. That could mean big shifts in rainfall patterns and a more unpredictable climate. So clear your drains, fix your roof and move to Wales – or at least to somewhere with good water supply. The worst that could happen? Your grandchildren will inherit inexorably rising temperatures that render much of the Earth uninhab...


Thursday 10 October 2013

Inter- and intra-specific pan-genomes of Borrelia burgdorferi sensu lato: genome stability and adaptive radiation

Conclusions: Intra- and inter-specific pan-genome sizes of B. burgdorferi s.l. expand linearly with phylogenetic diversity. Yet gene-acquisition rates in B. burgdorferi s.l. are among the lowest in bacterial pathogens, resulting in high genome stability and few lineage-specific genes. Genome adaptation of B. burgdorferi s.l. is driven predominantly by copy-number and sequence variations of lipoprotein genes. New genomic groups are likely to emerge if the current trend of B. burgdorferi s.l. population expansion continues. (Source: BMC Genomics - Latest articles)


Thursday 3 October 2013

A Germ Cell Tumor Masquerading as Bell Palsy

A 2-month-old girl with a germ cell tumor presented with right peripheral facial nerve palsy. Her vital signs and examination were normal except for right peripheral facial nerve palsy. Laboratory analyses revealed normal blood leukocyte count (6740/mm3), serum C-reactive protein (3 mg/L), and erythrocyte sedimentation rate (20 mm/h). Viral serology, Lyme titer, and peripheral blood smear were normal. Magnetic resonance imaging (MRI) of the brain and internal acoustic canal revealed no mass lesion (). She was diagnosed with Bell's palsy and was administered steroid treatment. (Source: Pediatric Neurology)

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Monday 30 September 2013

Multi-criteria decision analysis as an innovative approach to managing zoonoses: results from a study on Lyme disease in Canada

Conclusions: MCDA was used to structure key decision criteria and capture the complexity of Lyme disease management. This facilitated the identification of gaps in the scientific literature and enabled a clear identification of complementary interventions that could be used to improve the relevance and acceptability of proposed prevention and control strategy. Overall, MCDA presents itself as an interesting systematic approach for public health planning and zoonoses management with a "One Health" perspective. (Source: BMC Public Health - Latest articles)


Friday 20 September 2013

Vaccines against diseases transmitted from animals to humans: A one health paradigm.

Authors: Monath TP Abstract This review focuses on the immunization of animals as a means of preventing human diseases (zoonoses). Three frameworks for the use of vaccines in this context are described, and examples are provided of successes and failures. Framework I vaccines are used for protection of humans and economically valuable animal, where neither plays a role in the transmission cycle. The benefit of collaborations between animal health and human health industries and regulators in developing such products is discussed, and one example (West Nile vaccine) of a single product developed for use in animals and humans is described. Framework II vaccines are indicated for domesticated animals as a means of preventing disease in both animals and humans. The agents of concern ar...


Thursday 19 September 2013

Stephen E. Malawista, Lyme Disease Researcher, Dies at 79

Dr. Malawista and his team were credited with defining an ailment that was causing distress in Connecticut.     (Source: NYT Health)


Thursday 19 September 2013

Op-Ed Contributor: Bring Back the Lyme Vaccine

How a marketing fiasco derailed an important medical development.     (Source: NYT Health)


Wednesday 18 September 2013

Borrelia kurtenbachii sp. nov.: A widely distributed member of the Borrelia burgdorferi sensu lato species complex in North America.

Authors: Margos G, Piesman J, Lane RS, Ogden NH, Sing A, Straubinger RK, Fingerle V Abstract Lyme borreliosis group spirochetes are parasitic bacteria transmitted by vector ticks of the genus Ixodes and distributed mainly between 40° and 60° northern latitude. Since Borrelia burgdorferi sensu stricto (hereinafter, B. burgdorferi) was described in the northeastern USA during the early 1980s, an increasing diversity has been noted within the species complex. Here, we validate a new genospecies, Borrelia kurtenbachii sp. nov., that prevails in transmission cycles among vector ticks and reservoir hosts in North America. Confirmation of the presence of this species in Europe awaits further investigation. PMID: 24048870 [PubMed - as supplied by publisher] (Source: International Jou...


Wednesday 18 September 2013

Bring Back the Lyme Vaccine [OPINION]

Each year there are more than 30,000 cases of Lyme disease reported to the Centers for Disease Control and Prevention. But last month, the C.D.C. announced that the real number of annual infections was closer to 300,000. Shouldn’t there be a vaccine for such a prevalent and dangerous disease? (Source: RWJF News Digest - Public Health)

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Monday 16 September 2013

Borrelia burgdorferi BbHtrA degrades host ECM proteins and stimulates release of inflammatory cytokines in vitro

Summary The Lyme disease spirochaete, Borrelia burgdorferi, causes damage to diverse host tissues and induces inflammation but the mechanisms of injury are poorly understood. We recently reported that a surface‐exposed B. burgdorferi protease, which is expressed during human disease and is conserved within the major Lyme disease spirochaete species, degrades the extracellular matrix proteoglycan, aggrecan. Here we demonstrate that BbHtrA also degrades fibronectin and numerous proteoglycans found in skin, joints and neural tissues. BbHtrA degradation of fibronectin released known pro‐inflammatory fibronectin fragments FnIII13–14 and Fnf‐29, which may amplify the inflammatory processes triggered by the presence of the bacteria. When this hypothesis was tested directly by exposing c...


Monday 16 September 2013

Molecular detection and genetic identification of Borrelia garinii and Borrelia afzelii from patients presenting with a rare skin manifestation of prurigo pigmentosa in Taiwan

Conclusions: This study provides the first evidence of B. garinii and B. afzelii isolated and identified in patients with PP. Whether this unusual skin lesion is a new manifestation of Lyme disease needs to be studied further. (Source: International Journal of Infectious Diseases)


Monday 9 September 2013

Juice feasting can heal Lyme disease naturally

Lyme disease is the most common tick-borne illness in North America and Europe. Deer ticks, which feed on the blood of animals and humans, can harbor the bacteria - Borrelia burgdorferi - and spread it when feeding. You're more likely to get Lyme disease if you live... (Source: NaturalNews.com)


Monday 9 September 2013

[Lyme arthritis in children: A diagnostic trap.]

We report the case of an 8-year old girl with knee arthritis treated as septic arthritis in a region where Lyme disease is rare. Six days later, clinical and biological worsening suggested that the diagnosis had to be reconsidered. Lyme arthritis was confirmed by serology. Treatment was adapted and the progression was positive. This case reminds us that, in children, Lyme arthritis may look alike septic arthritis or juvenile rheumatoid arthritis and must be considered as a possible diagnosis, even in low-incidence areas. PMID: 24028811 [PubMed - as supplied by publisher] (Source: Archives de Pediatrie)

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Friday 6 September 2013

Distinctive Immunoglobulin VH Gene Features of Cutaneous Marginal Zone Lymphomas in Asian Cases

This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)


Friday 6 September 2013

B. burgdorferi PUR Domain Protein [Gene Regulation]

The PUR domain is a nucleic acid-binding motif found in critical regulatory proteins of higher eukaryotes and in certain species of bacteria. During investigations into mechanisms by which the Lyme disease spirochete controls synthesis of its Erp surface proteins, it was discovered that the borrelial PUR domain protein, Bpur, binds with high affinity to double-stranded DNA adjacent to the erp transcriptional promoter. Bpur was found to enhance the effects of the erp repressor protein, BpaB. Bpur also bound single-stranded DNA and RNA, with relative affinities RNA > double-stranded DNA > single-stranded DNA. Rational site-directed mutagenesis of Bpur identified amino acid residues and domains critical for interactions with nucleic acids, and it revealed that the PUR domain has a distinct me...


Tuesday 3 September 2013

Don’t Get Ticked Off Over Chronic Lyme Disease

An empathic health care provider will need to explain the problems with the theory of chronic Lyme disease, and do what should be done whenever a patient comes in for the evaluation of chronic pain and fatigue: provide support, embark on a thorough medical evaluation, and gently advise them that the proffering of cures when there are none can be dangerous.read more (Source: Psychology Today Depression Center)


Tuesday 3 September 2013

Borrelia burgdorferi HtrA May Promotes Dissemination and Irritation

(Source: Molecular Microbiology)


Tuesday 3 September 2013

Borrelia burgdorferi HtrA May Promote Dissemination and Irritation

(Source: Molecular Microbiology)

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Friday 30 August 2013

Two years of hell with Lyme

For most people it starts with a telltale, bulls-eye rash and flu-like symptoms. But what if you never get the rash? What if you blow off your symptoms as a bad case of the flu? (Source: CNN.com - Health)


Friday 30 August 2013

BBA70 Is a Potent Plasminogen-binding Protein [Microbiology]

The Lyme disease spirochete Borrelia burgdorferi lacks endogenous, surface-exposed proteases. In order to efficiently disseminate throughout the host and penetrate tissue barriers, borreliae rely on recruitment of host proteases, such as plasmin(ogen). Here we report the identification of a novel plasminogen-binding protein, BBA70. Binding of plasminogen is dose-dependent and is affected by ionic strength. The BBA70-plasminogen interaction is mediated by lysine residues, primarily located in a putative C-terminal α-helix of BBA70. These lysine residues appear to interact with the lysine-binding sites in plasminogen kringle domain 4 because a deletion mutant of plasminogen lacking that domain was unable to bind to BBA70. Bound to BBA70, plasminogen activated by urokinase-type plasminogen a...


Friday 30 August 2013

Prevalence of borreliosis, anaplasmosis, ehrlichiosis and Dirofilaria immitis in dogs and vectors in Voronezh Reserve (Russia).

Authors: Volgina NS, Romashov BV, Romashova NB, Shtannikov AV Abstract Most of the dogs studied for the prevalence of CVBD have previously received acaricidal and insecticidal treatments. In the present work, a very specific population of dogs (Group 1) that had never been treated against ticks and mosquitoes was studied. Moreover, the territory occupied by this population has also never been treated, because it is a protected area - Voronezh Natural Reserve. Canine patients from veterinary clinics (Group 2) that had been treated against VBD vectors were studied for comparison. Eighty-two dogs (Group 1) were enrolled in June, 2008. Blood samples were tested using the IDEXX SNAP(®) 4Dx(®) test. A specific heartworm antigen was detected in 12.2% samples. The seroprevalence for Anap...


Thursday 29 August 2013

Untreated Lyme disease: 2 years of hell

For most people it starts with a telltale, bulls-eye rash and flu-like symptoms. But what if you never get the rash? What if you blow off your symptoms as a bad case of the flu? (Source: CNN.com - Health)


Thursday 29 August 2013

Differential Diagnosis and the Suspension of Judgment.

Authors: Kennedy AG Abstract In this paper I argue that ethics and evidence are intricately intertwined within the clinical practice of differential diagnosis. Too often, when a disease is difficult to diagnose, a physician will dismiss it as being "not real" or "all in the patient's head." This is both an ethical and an evidential problem. In the paper my aim is two-fold. First, via the examination of two case studies (late-stage Lyme disease and Addison's disease), I try to elucidate why this kind of dismissal takes place. Then, I propose a potential solution to the problem. I argue that instead of dismissing a patient's illness as "not real," physicians ought to exercise a compassionate suspension of judgment when a diagnosis cannot be immediately made. I argue that suspending j...

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Wednesday 28 August 2013

Borrelia burgdorferi BbHtrA degrades host ECM proteins and stimulates release of inflammatory cytokines in vitro

Summary The Lyme disease spirochete, Borrelia burgdorferi, causes damage to diverse host tissues and induces inflammation but the mechanisms of injury are poorly understood. We recently reported that a surface‐exposed B. burgdorferi protease, which is expressed during human disease and is conserved within the major Lyme disease spirochete species, degrades the extracellular matrix proteoglycan, aggrecan. Here we demonstrate that BbHtrA also degrades fibronectin and numerous proteoglycans found in skin, joints and neural tissues. BbHtrA degradation of fibronectin released known pro‐inflammatory fibronectin fragments FnIII13‐14 and Fnf‐29 which may amplify the inflammatory processes triggered by the presence of the bacteria. When this hypothesis was tested directly by exposing chondr...


Tuesday 27 August 2013

Rise in Diagnoses of Lyme Disease

New preliminary reports from the Centers for Disease Control and Prevention (CDC) estimate that around 300,000 Americans are diagnosed with Lyme disease each year—an estimate ten times higher than the yearly reported number of 30,000. These estimates are based on results from three ongoing studies by the CDC that use various methods to define the average number of people diagnosed with Lyme disease. From the CDC brief: The first project analyzes medical claims information for approximately 22 million insured people annually for six years, the second project is based on a survey of clinical laboratories and the third project analyzes self-reported Lyme disease cases from a survey of the general public. The high number of Americans diagnosed with this disease highlights the need for awaren...


Tuesday 27 August 2013

Americans Diagnosed With Lyme Disease Annually

CDC Estimates Americans Diagnosed With Lyme Disease Annually (Source: eMedicineHealth.com)


Tuesday 27 August 2013

Tomography captures flagellar assembly in cells [Microbiology]

In this study, we genetically trapped intermediates in flagellar assembly and determined the 3D structures of the intermediates to 4-nm resolution by cryoelectron tomography. We provide structural evidence that secretion... (Source: Proceedings of the National Academy of Sciences)


Monday 26 August 2013

Imugen develops deer tick-borne blood test to detect infection

Norwood-based Imugen Inc., a clinical laboratory specializing in specimen testing of tick-borne disease, has launched a new blood test designed to detect the presence of the deer tick-borne bacteria, Borrelia miyamotoi. Miyamotoi is recognized as the fourth deer tick-borne infection along side Lyme disease, Babesia and Anaplasma. In an interview with Mass High Tech, Imugen’s medical director and rheumatologist at Jordan Hospital, Dr. Philip J. Molloy said Borrelia miyamotoi, a spirochete bacteria… (Source: bizjournals.com Health Care:Hospitals headlines)

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Monday 26 August 2013

Lyme Disease Skyrockets

Public Health: Some 300,000 cases of tick-borne illness occur each year in the U.S., 10 times previous estimates (Source: Chemical and Engineering News)


Friday 23 August 2013

Lyme Disease is in the News

. To learn more, visit the MedlinePlus Lyme Disease health topic page. Lyme disease is a bacterial infection you get from the bite of an infected tick... (Source: What's New on MedlinePlus)


Wednesday 21 August 2013

Lyme disease common in U.S.

The blacklegged ticks are out, and they're infecting hundreds of thousands of Americans each year with a bacterial illness. (Source: CNN.com - Health)


Wednesday 21 August 2013

CDC: Lyme disease more common than we thought

The blacklegged ticks are out, and they're infecting hundreds of thousands of Americans with a bacterial illness -- more often than experts previously thought. (Source: WDSU.com - Health)


Wednesday 21 August 2013

Lyme disease in the US is '10-times underreported'

The number of Lyme disease cases diagnosed in the US every year is around 300,000, according to new figures released by the Centers for Disease Control and Prevention (CDC). This number is about 10 times higher than the number officially reported. CDC officials presented their new preliminary estimates in Boston on Sunday at the 2013 International Conference on Lyme Borreliosis and Other Tick-Borne Diseases. Lyme disease is the most commonly reported tick-borne illness in the US, where every year the CDC receives reports on 30,000 cases... (Source: Health News from Medical News Today)

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Tuesday 20 August 2013

CDC: Lyme disease more common than we thought

The blacklegged ticks are out, and they're infecting hundreds of thousands of Americans each year with a bacterial illness. (Source: CNN.com - Health)


Tuesday 20 August 2013

CDC: Why Is Lyme Disease Activity So Much Higher Than Predicted?

Upwards of 300,000 people may be affected by Lyme disease each year – 10 times more than previously estimated. (Source: Forbes.com Healthcare News)


Tuesday 20 August 2013

U.S. Lyme Disease Cases Vastly Underreported: CDC

Title: U.S. Lyme Disease Cases Vastly Underreported: CDCCategory: Health NewsCreated: 8/19/2013 12:35:00 PMLast Editorial Review: 8/20/2013 12:00:00 AM (Source: MedicineNet Hepatitis C General)


Tuesday 20 August 2013

New Tick-Borne Illness Being Diagnosed In Mass.

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Tuesday 20 August 2013

An Estimated 300,000 Americans Diagnosed with Lyme Disease Each Year (FREE)

By the Editors Over 30,000 cases of Lyme disease are reported to the CDC each year, but the actual number of annual cases is roughly … (Source: Physician's First Watch current issue)

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Tuesday 20 August 2013

Actual U.S. Lyme disease about 300,000 cases a year

ATLANTA, Aug. 19 (UPI) -- Each year, more than 30,000 cases of Lyme disease are reported to federal health officials, but U.S. researchers say the actual number is closer to 300,000. (Source: Health News - UPI.com)


Monday 19 August 2013

Video: Sequester cutting 57k kids out of Head Start

The CBS News Roundup: The White House says it continues to 'evaluate' the situation in Egypt, refusing once again to call the military takeover there a "coup"; Lyme disease is ten times more common than previously thought; Sequestration budget cuts will force more than 57,000 children out of Head Start -- all this and more. Nick Dietz reports on the news you need to know. (Source: Health News: CBSNews.com)


Monday 19 August 2013

Lyme Disease Far More Common Than Previously Known

Fewer than 30,000 cases of the tick-borne illness are reported each year. But the CDC says surveys of labs that test for the disease, six years of insurance claims and other surveillance methods suggest that the number of infections is actually ten times higher.» E-Mail This     » Add to Del.icio.us (Source: NPR Health and Science)


Monday 19 August 2013

New Lyme Culture Test Failed CDC AnalysisNew Lyme Culture Test Failed CDC Analysis

Most 'positive' patient samples reported were contaminated by laboratory strains used to develop the test method and were likely false-positives. Medscape Medical News (Source: Medscape Today Headlines)


Monday 19 August 2013

Video: CDC: Lyme disease rates 10 times higher than previously reported

New Lyme disease numbers from gov't health officials show about 300,000 Americans are diagnosed with the tick-borne illness each year. Jericka Duncan reports. (Source: Health News: CBSNews.com)

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Monday 19 August 2013

CDC: Lyme disease rates 10 times higher than previously reported

Typically up to 30,000 Lyme disease cases reported to CDC each year, but new report finds number closer to 300,000 infected (Source: Health News: CBSNews.com)


Monday 19 August 2013

Lyme Disease Cases 10 Times Higher Than Previously Reported

ATLANTA (AP) — Lyme disease is about 10 times more common than previously reported, health officials said Monday. As many as 300,000 Americans are actually diagnosed with Lyme disease each year, the Centers for Disease Control and Prevention announced. Read: CDC report Usually, only 20,000 to 30,000 illnesses are reported each year. For many years, CDC officials have known that many doctors don’t report every case and that the true count was probably much higher. The new figure is the CDC’s most comprehensive attempt at a better estimate. The number comes from a survey of seven national laboratories, a national patient survey and a review of insurance information. “It’s giving us a fuller picture and it’s not a pleasing one,” said Dr. Paul Mead, who o...


Monday 19 August 2013

CDC Provides Estimate of Americans Diagnosed with Lyme Disease Each Year

Source: Centers for Disease Control and Prevention Related MedlinePlus Page: Lyme Disease (Source: MedlinePlus Health News)


Monday 19 August 2013

Lyme Disease Far More Common than Previously Known

The Centers for Disease Control and Prevention says 300,000 Americans are getting Lyme disease every year, and the toll is growing. (Source: RWJF News Digest - Public Health)


Friday 16 August 2013

Ixodes ricinus abundance and its infection with the tick-borne pathogens in urban and suburban areas of Eastern Slovakia

We investigated the occurrence and seasonal activity of Ixodes ricinus ticks in correlation with microclimatic factors. The risk of infection with the tick-borne bacterial agents (Borrelia, Anaplasma and Neoehrlichia was confronted with the reported Lyme borreliosis cases in the studied areas of Slovakia. Image: Questing Ixodes ricinus female. (Source: Parasites and Vectors)

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Wednesday 14 August 2013

Evaluation of Recombinant Protein TpF1 of Treponema pallidum for Serodiagnosis of Syphilis.

Authors: Jiang C, Zhao F, Xiao J, Zeng T, Yu J, Ma X, Wu H, Wu Y Abstract Syphilis is a chronic infection caused by Treponema pallidum subsp. pallidum, and the diagnosis of syphilis with sensitive and specific methods is challenging and important for the prevention and treatment of syphilis. In present study, we established a recombinant protein TpF1-based indirect immunoglobulin G (IgG) enzyme-linked immunosorbent assay (ELISA) and Western blot assay for human and rabbit sera. The 20-kDa recombinant protein TpF1 was detected by Western blotting probed with sera from rabbits immunized with recombinant TpF1 and infected with T.pallidum Nichols strain and T.pallidum clinical isolates, but was not detected probed with sera from uninfected rabbits. The sensitivity of the recombinant pr...


Wednesday 14 August 2013

Diagnostic value of cytokines and chemokines in Lyme neuroborreliosis.

Authors: Cerar T, Ogrinc K, Lotric-Furlan S, Kobal J, Levicnik-Stezinar S, Strle F, Ruzic-Sabljic E Abstract The aim of the present study was to assess concentrations of different cytokines and chemokines in serum and CSF of patients with Lyme neuroborreliosis, and to identify possible marker(s) that would enable distinction between clinically evident and suspected Lyme neuroborreliosis as well as between Lyme neuroborreliosis and tick-borne encephalitis (TBE). Our additional interest was to evaluate relationship between cytokine/chemokine concentrations and B. burgdorferi sensu lato isolation from CSF as well as intrathecal synthesis of specific borrelial antibodies.We found that higher concentrations of CXCL 13 and lower concentrations of IL-10 in sera were associated with higher...


Saturday 10 August 2013

Assessment of Transcriptional Activity of Borrelia burgdorferi and Host Cytokine Genes During Early and Late Infection in a Mouse Model

Vector-Borne and Zoonotic Diseases , Vol. 0, No. 0. (Source: Vector-Borne and Zoonotic Diseases)


Thursday 1 August 2013

Phthriasis palpebrarum can resemble tick larva infestation in an eyelid

We present a case of phthiriasis palpebrarum in a 4-year-old boy. (Source: Journal of AAPOS)


Tuesday 30 July 2013

Delayed diagnosis of lyme neuroborreliosis presenting with abducens neuropathy without intrathecal synthesis of borrelia antibodies.

We report a case of possible Lyme neuroborreliosis presenting with sixth cranial nerve neuropathy at the onset of the disease further developing into typical meningoradiculitis and multiple mononeuropathy. Surprisingly, Borrelia burgdorferi antibodies were not detected in the cerebrospinal fluid. PMID: 23888345 [PubMed - in process] (Source: Medicina (Kaunas))


Tuesday 30 July 2013

Lyme Disease DebateLyme Disease Debate

This new article gives an overview of how Lyme disease was discovered, and describes how it has become one of the most common vectorborne infections in North America and how it affects humans.  Environmental Health Perspectives (Source: Medscape Today Headlines)


Monday 29 July 2013

Potential Misdiagnoses of Bell's Palsy in the Emergency Department

Conclusion: Emergency providers have a very low rate of misdiagnosing Bell's palsy. The association between imaging use and misdiagnosis is likely confounded by patient acuity. Increasing age and diabetes are modest risk factors for misdiagnosis. (Source: Annals of Emergency Medicine)


Friday 26 July 2013

Chronic Lyme Disease: Liberation from Lyme Denialism

The Review article by Halperin et al concerning Lyme disease “misconceptions” is the latest in a series of Lyme denialist attacks by members and supporters of the Infectious Diseases Society of America (IDSA). This series of copycat opinion pieces is disturbing from both a scientific and political perspective because the articles frame the complex debate over chronic Lyme disease in terms of “evidence-based medicine” on the one hand, versus “antiscience” on the other. Furthermore, the latest Lyme denialist attacks appear to be a concerted effort to offset recent political action aimed at helping the scores of untreated, undertreated, and mistreated Lyme disease patients around the globe. (Source: The American Journal of Medicine)


Friday 26 July 2013

The Reply

Miller's letter further illustrates the misconceptions about Lyme disease. The assertion that Lyme “ELISA [enzyme-linked immunosorbent assay] tests are intrinsically unreliable” is inaccurate. In the majority of patients with very early Borrelia burgdorferi infection, typically an erythema migrans, antibody is undetectable; such patients should be treated without testing. Serologic testing also may be negative in occasional patients with other early manifestations, such as facial nerve palsy. Here a convalescent titer will almost always be positive, just as in other diseases. With these few specific exceptions, related to the normal temporal evolution of the immune response, false negatives are extremely rare. In fact, false positives are a greater problem, particularly with ELISAs, i...


Friday 26 July 2013

Alternative Considerations for “Common Misconceptions About Lyme Disease”

Alternative considerations are presented for the article “Common Misconceptions About Lyme Disease.” Are serology tests for Lyme disease reliable? Enzyme-linked immunosorbent assays may provide false-negative results not only because of the time delay for the patient's immune system to produce the antibodies but also because the various enzyme-linked immunosorbent assays are intrinsically unreliable. (Source: The American Journal of Medicine)

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Friday 26 July 2013

[Articles] Safety and immunogenicity of a novel multivalent OspA vaccine against Lyme borreliosis in healthy adults: a double-blind, randomised, dose-escalation phase 1/2 trial

The novel multivalent OspA vaccine could be an effective intervention for prevention of Lyme borreliosis in Europe and the USA, and possibly worldwide. Larger confirmatory formulation studies will need to be done that include individuals seropositive for Borrelia burgdorferi sensu lato before placebo-controlled phase 3 efficacy studies can begin. (Source: The Lancet Infectious Diseases)


Friday 26 July 2013

[Comment] Lyme disease vaccination: are we ready to try again?

Borrelia burgdorferi—the spirochete that causes Lyme disease—was first identified in 1981. By 1983, it was known that most patients with Lyme disease have antibodies to a 31 kD protein that would come to be known as outer surface protein A (OspA). Antibodies against OspA were shown to protect laboratory animals against experimental infection with B burgdorferi. Research in the 1990s According to several models, the vaccine was cost effective for individuals at high risk of infection. However, in early 2002, LYMErix was voluntarily withdrawn from the market, merely 38 months after its approval. (Source: The Lancet Infectious Diseases)


Monday 22 July 2013

Borrelia burgdorferi Oxidative Stress Regulator BosR Directly Represses Lipoproteins Primarily Expressed in the Tick during Mammalian Infection

Summary Differential gene expression is a key strategy adopted by the Lyme disease spirochaete, Borrelia burgdorferi, for adaptation and survival in the mammalian host and the tick vector. Many B. burgdorferi surface lipoproteins fall into two distinct groups according to their expression patterns: one group primarily expressed in the tick and the other group primarily expressed in the mammal. Here, we show that the Fur homologue in this bacterium, also known as Borrelia oxidative stress regulator (BosR), is required for repression of outer surface protein A (OspA) and OspD in the mammal. Furthermore, BosR binds directly to sequences upstream of the ospAB operon and the ospD gene through recognition of palindromic motifs similar to those recognized by other Fur homologues but with a 1‐bp...


Friday 19 July 2013

Illuminating the roles of the Borrelia burgdorferi adhesins.

Authors: Coburn J, Leong J, Chaconas G Abstract The Lyme disease spirochetes, Borrelia burgdorferi (sensu lato), must cause persistent, disseminated infection to be maintained in the natural enzootic cycle. In human Lyme disease, spirochetes spread from the site of a tick bite to colonize multiple tissue sites, causing multisystem clinical manifestations. The Lyme spirochetes produce many adhesive surface proteins that collectively recognize diverse host substrates and cell types and are likely to promote dissemination and chronic infection in a variety of tissues. Recent application of state-of-the-art in vivo imaging technologies is illuminating mechanisms of interaction of B. burgdorferi with the host and the importance of multiple adhesins during mammalian infection. PMID: ...

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Thursday 18 July 2013

How Do Tick-Borne Diseases Evade The Tick's Immune System?

Ticks, blood-sucking arthropods that occur across the world, can transmit viruses, bacteria, and protozoa that threaten the health of their vertebrate hosts. Dangerous diseases transmitted by ticks include Lyme disease, which attacks humans in Europe and the USA and is caused by Borrellia bacteria; babesiosis, caused by the protozoan Babesia (a relative of the malaria parasite) that infects pets, cattle, and sometimes humans; and anaplasmosis, caused by the Anaplasma bacterium, which can have serious effects on cattle... (Source: Health News from Medical News Today)


Thursday 18 July 2013

The Lyme disease spirochete Borrelia burgdorferi induces inflammation and apoptosis in cells from dorsal root ganglia

Conclusion: In this model, B. burgdorferi induced an inflammatory response and neuronal apoptosis of DRG. These pathophysiological processes could contribute to peripheral neuropathy in LNB. (Source: Journal of Neuroinflammation)


Thursday 18 July 2013

Cyclosporiasis Outbreaks

It's summertime. We are supposed to get a break from getting sick this time of year, right? While that is mostly true, as we don't usually have any big outbreaks like we do during cold and flu season, it does seem like there is always something going around during the summer. This includes diseases  like Lyme disease and Rocky Mountain spotted fever (tick-borne diseases), West Nile virus infections (from mosquitoes), and many viral infections that are more common during the summer months....Read Full Post (Source: About.com Pediatrics)


Thursday 18 July 2013

How to stay safe during bug season

Welcome to bug season, when mosquitoes, ticks and other creepy crawlers make even the bravest mom hesitant to let her kids go outside. Not only are insects annoying, they can carry diseases such as West Nile virus and Lyme disease. (Source: WDSU.com - Health)


Wednesday 17 July 2013

Startle Myoclonus Induced by Lyme NeuroborreliosisStartle Myoclonus Induced by Lyme Neuroborreliosis

Lyme neuroborreliosis can present in many unusual ways, but this patient may be the first to present with an exaggerated startle reflex. Journal of Medical Case Reports (Source: Medscape Today Headlines)

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Wednesday 17 July 2013

Encephalitis In New York State And Black-Legged Ticks Linked

The number of tick-borne illnesses reported to the U.S. Centers for Disease Control and Prevention is on the rise. Lyme disease leads the pack, with some 35,000 cases reported annually. In the Northeast, the black-legged ticks (Ixodes scapularis) that spread Lyme disease also infect people with other maladies, among them anaplasmosis, babesiosis, and - as a new paper in the journal Parasites and Vectors reports - Powassan encephalitis. Powassan encephalitis is caused by Powassan virus and its variant, deer tick virus... (Source: Health News from Medical News Today)


Tuesday 16 July 2013

Selection of Neighborhood Controls for a Population-Based Lyme Disease Case-Control Study by Using a Commercial Marketing Database

This report describes the utility of the InfoUSA.com (InfoGroup, Papillion, Nebraska) commercial marketing database for neighborhood control recruitment in a Lyme disease case-control study in Connecticut during 2005–2007. (Source: American Journal of Epidemiology)


Monday 15 July 2013

Letters: Pets and Lyme Disease (1 Letter)

A letter to the Editor.     (Source: NYT Health)


Monday 15 July 2013

Black-legged ticks linked to encephalitis in New York state

(Cary Institute of Ecosystem Studies) Ostfeld concludes: "When patients present with encephalitis symptoms in areas with high levels of Lyme disease, especially during the summer, physicians need to consider Powassan encephalitis. While rare, it's associated with significant complications. There is no vaccine or specific antiviral therapy, the best strategy remains prevention." (Source: EurekAlert! - Medicine and Health)


Friday 12 July 2013

The Disease That Looks Like Lyme--But Isn't

A newly identified disease spread by deer ticks may be among one of the new summer illnesses to be on the lookout for if you spend time outside in the Northeast and upper Midwest. The disease is referred to as Borriela miyamotoi. (Source: Forbes.com Healthcare News)

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Thursday 11 July 2013

Lyme disease or a complication of delusional parasitosis?

Authors: Brakoulias V PMID: 23847121 [PubMed - as supplied by publisher] (Source: The Australian and New Zealand Journal of Psychiatry)


Wednesday 10 July 2013

Structure of an atypical periplasmic adaptor from a multidrug efflux pump of the spirochete Borrelia burgdorferi

Highlights: Abstract: Periplasmic adaptor proteins are essential components of bacterial tripartite multidrug efflux pumps. Here we report the 2.35Å resolution crystal structure of the BesA adaptor from the spirochete Borrelia burgdorferi solved using selenomethionine derivatized protein. BesA shows the archetypal linear, flexible, multi-domain architecture evident among proteobacteria and retains the lipoyl, β-barrel and membrane-proximal domains that interact with the periplasmic domains of the inner membrane transporter. However, it lacks the α-hairpin domain shown to establish extensive coiled-coil interactions with the periplasmic entrance helices of the outer membrane-anchored TolC exit duct. This has implications for the modelling of assembled tripartite efflux pumps. (Source: FE...


Tuesday 9 July 2013

Borrelia burgdorferi sensu lato prevalence in tick populations in Estonia

This study is the first survey of the presence, the prevalence and the genetic characteristics of Borrelia burgdorferi s.l. in Ixodes ricinus and I. persulcatus ticks in Estonia. Image: Lyme Borreliosis incidence rate per 100 000 population in Estonia 2000 ? 2012. (Source: Parasites and Vectors)


Tuesday 9 July 2013

Borrelia bavariensis sp. nov. is widely distributed in Europe and Asia.

Authors: Margos G, Wilske B, Sing A, Hizo-Teufel C, Cao WC, Chu C, Scholz H, Straubinger RK, Fingerle V Abstract Since the original description of Borrelia bavariensis sp. nov. in 2009, additional samples available from humans and ticks from Europe and Mongolia, respectively, have been used to further characterize Borrelia strains belonging to this group of spirochetes that utilize rodents as reservoir hosts. These investigations suggested the presence of related strains in Europe and Asia and confirmed their status as a distinct species. Furthermore, samples that were investigated by researchers from China and Japan confirm the ecological relationship of members of this proposed species with rodents and suggest that it has a wide distribution in Eurasia. Here, we use phylogenetic ...


Monday 8 July 2013

Well: When Lyme Disease Lasts and Lasts

Often misdiagnosed and mistreated, chronic Lyme disease leaves thousands of people physically and mentally debilitated and without a medically established recourse.     (Source: NYT Health)

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Monday 8 July 2013

Personal Health: When Lyme Disease Lasts and Lasts

Often misdiagnosed and mistreated, chronic Lyme disease leaves thousands of people physically and mentally debilitated and without a medically established recourse.     (Source: NYT Health)


Friday 5 July 2013

Keeping Bugs Away: 5 Things You Need To Know

The other day, as dusk fell on an afternoon outdoor party, my kids started swatting and itching. Oh, that’s right, I thought: it’s mosquito season. I remembered hearing about West Nile virus being found in some mosquitoes and kicked myself for not bringing bug spray. At the same party, a friend showed me a rash on her son’s leg. By the next day, it had turned into a classic Lyme disease rash. Definitely bug season. If you haven’t done so already, it’s time to get smart about preventing mosquito and tick bites. Here’s what you need to know: 1. The best protection against both mosquitoes and ticks is DEET (N, N-diethyl-meta-toluamide). This stuff really works (the smell of it keeps the bugs away). The higher the percentage of DEET, the longer it works: 10 percent works for a coup...


Tuesday 2 July 2013

Spillover Of Infectious Diseases Among Wildlife, Domestic Animals And People; Links Found Between Environment And Human Health

West Nile virus, Lyme disease and hantavirus. All are infectious diseases spreading in animals and in people. Is human interaction with the environment somehow responsible for the increase in these diseases? The ecology and evolution of infectious diseases will be highlighted at two symposia at the Ecological Society of America's annual meeting, held from Aug. 5-9 in Minneapolis, Minn. One symposium will address human influences on viral and bacterial diseases through alteration of landscapes and ecological processes... (Source: Health News from Medical News Today)


Tuesday 2 July 2013

Borrelia miyamotoi Infection Presenting as Human Granulocytic Anaplasmosis: A Case Report.

CONCLUSION: The presence of B. miyamotoi DNA in the peripheral blood and the patients' eventual therapeutic response to doxycycline are consistent with the hypothesis that their illness was due to this newly recognized spirochete. Samples from tick-exposed patients acutely presenting with signs of HGA but who have a delayed response to doxycycline therapy or negative confirmatory test results for HGA should be analyzed carefully for evidence of B. miyamotoi infection. PRIMARY FUNDING SOURCE: National Institutes of Health and the Evelyn Lilly Lutz Foundation. PMID: 23817701 [PubMed - in process] (Source: Annals of Internal Medicine)


Monday 1 July 2013

Ten hyped highs, the poison squad, and Lyme disease: Weekly Web Review in Toxicology

Thefix.com interviews medical toxicologist Dr. Jeff Lapoint for a “Straight look at 10 Hyped Highs.” Topics include salvia, methoxetamine (“Mexxy”), Benzo Fury (6-APB), kratom, and Bromo Dragonfly. Worth reading. At Esquire, Bruce Watson writes about “The Poison Squad: An Incredible HIstory.” This piece tells the story of a project, run by Dr. Harvey Washington Wiley in the very early years of the twentieth century, to investigate the potential health hazards of various food additives. Officially called the “hygienic table trials”, the were quickly— and more accurately — dubbed the “poison squad”. Volunteers were fed increasings amounts of additives such as borax, sulfuric acid, saltpeter, formaldehyde, and copper sulfate. Wi...

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Monday 1 July 2013

Optimization of Pulse-Field Gel Electrophoresis for Borrelia burgdorferi Subtyping.

CONCLUSION: PFGE can be used as a valuable test for routine genospecies identification of B. burgdorferi. PMID: 23895704 [PubMed - in process] (Source: Biomedical and Environmental Sciences : BES)


Monday 1 July 2013

Atypical Location of Lymphocytoma Cutis in a Child

Abstract Lyme borreliosis is a common infectious disease that can affect myocardial muscle or the central nervous system if not treated at an early stage. Here we report a unique case of an atypical location of lymphocytoma cutis in a 3‐year‐old boy. Histologic and immunohistochemical analysis revealed the correct diagnosis. (Source: Pediatric Dermatology)


Monday 1 July 2013

Does high biodiversity reduce the risk of Lyme disease invasion?

In a zone of Lyme disease emergence, host biodiversity did not inhibit Ixodes scapularis tick invasion by the 'dilution effect', but there was evidence for wider community biodiversity to be inhibiting tick invasion. Image: Ixodes scapularis larvae feeding on the ear of a Peromyscus leucopus mouse. (Source: Parasites and Vectors)


Saturday 29 June 2013

Tick Safety Tips for Kids at Summer Camp

Experts describe steps to prevent Lyme disease, other illnesses Source: HealthDay Related MedlinePlus Pages: Children's Health, Tick Bites (Source: MedlinePlus Health News)


Friday 28 June 2013

Interplay of ecology, infectious disease, wildlife and human health featured at annual conference

(National Science Foundation) West Nile virus, Lyme disease and hantavirus. All are infectious diseases spreading in animals and in people. Is human interaction with the environment somehow responsible for the increase in these diseases? (Source: EurekAlert! - Medicine and Health)

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Friday 28 June 2013

Molecular Basis of Borrelia Immune Evasion [Protein Structure and Folding]

Borrelia burgdorferi spirochetes that cause Lyme borreliosis survive for a long time in human serum because they successfully evade the complement system, an important arm of innate immunity. The outer surface protein E (OspE) of B. burgdorferi is needed for this because it recruits complement regulator factor H (FH) onto the bacterial surface to evade complement-mediated cell lysis. To understand this process at the molecular level, we used a structural approach. First, we solved the solution structure of OspE by NMR, revealing a fold that has not been seen before in proteins involved in complement regulation. Next, we solved the x-ray structure of the complex between OspE and the FH C-terminal domains 19 and 20 (FH19-20) at 2.83 Å resolution. The structure shows that OspE binds FH19-20 ...


Thursday 27 June 2013

Dynamic interplay of ecology, infectious disease, and human life

(Ecological Society of America) Two symposia focusing on the ecological dynamics of infectious diseases such as avian influenza, Yellow Fever, and Lyme will take place during the Ecological Society of America's 98th Annual Meeting, held this year in Minneapolis, Minnesota. One will look at human influences on viral and bacterial diseases through our alteration of landscapes and ecological processes, while the other will focus on the emerging field of eco-epidemiology that seeks to integrate biomedical and ecological research approaches to address human health threats. (Source: EurekAlert! - Medicine and Health)


Wednesday 26 June 2013

'The Lyme Wars' That Tiny Ticks Have Wrought

Since Lyme disease was first identified in the late 1970s, it has become the most commonly reported tick-borne illness in the country. Journalist Michael Specter talks about his New Yorker article on the disease and its controversial history.» E-Mail This     » Add to Del.icio.us (Source: NPR Health and Science)


Wednesday 26 June 2013

Protect Yourself against Tick-Borne Disease

Source: Food and Drug Administration Related MedlinePlus Pages: Lyme Disease, Tick Bites (Source: MedlinePlus Health News)


Wednesday 26 June 2013

Protect Yourself Against Tick-Borne Disease

The best known tick-borne diseases in the U.S. are Lyme disease and Rocky Mountain fever, but scientists at the Food and Drug Administration found an increasing number of cases of babesiosis, a serious disease caused by a parasite carried by the same ticks that carry Lyme disease. Learn about these diseases and how to avoid them. (Source: FDA Consumer Updates)

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Monday 24 June 2013

Dynamics of connective-tissue localization during chronic Borrelia burgdorferi infection

Authors: Denise M Imai, Sunlian Feng, Emir Hodzic & Stephen W Barthold (Source: Laboratory Investigation AOP)


Thursday 20 June 2013

Spatial and seasonal variation in the prevalence of Anaplasma phagocytophilum and Borrelia burgdorferi sensu lato in questing Ixodes ricinus ticks in Norway

Prevalence of LBS was higher in adult female ticks (21.6%) compared to adult male ticks (11.5%) and nymphs (10.9%), while prevalence of A. phagocytophilum was 8.8%. Prevalence of both bacteria was much higher in May compared to August. Image: Adult female Ixodes ricinus. (Source: Parasites and Vectors)


Wednesday 19 June 2013

A call to order at the spirochaetal host–pathogen interface

Summary As the Lyme disease spirochaete Borrelia burgdorferi shuttles back and forth between arthropod vector and vertebrate host, it encounters vastly different and hostile environments. Major mechanisms contributing to the success of this pathogen throughout this complex transmission cycle are phase and antigenic variation of abundant and serotype‐defining surface lipoproteins. These peripherally membrane‐anchored virulence factors mediate niche‐specific interactions with vector/host factors and protect the spirochaete from the perils of the mammalian immune response. In this issue of Molecular Microbiology, Tilly, Bestor and Rosa redefine the roles of two lipoproteins, OspC and VlsE, during mammalian infection. Using a variety of promoter fusions in combination with a sensitive in...


Monday 17 June 2013

Mother diagnosed with MS and facing life in a wheelchair is cured - after she discovered her symptoms were due to a TICK BITE

After years of expensive drug therapy and injections for MS, a simple course of antibiotics has cleared Julia Marshall-Wessendorf, 37, from Bath, of all her symptoms. She believes she was suffering from Lyme disease. (Source: the Mail online | Health)


Sunday 16 June 2013

Durham Veterinarian Warns of Summer Flea and Tick Season for Pets

DURHAM, N.C., June 16, 2013 (GLOBE NEWSWIRE) -- New Hope Animal Hospital in Durham, NC is reminding pet owners about the dangers of summer flea and tick season. According to veterinarian Dr. Soren Windram, pets need medicated protection to prevent health problems including worms, flea dermatitis, and tick-borne diseases, including Lyme Disease, ehrlichia and babesia. The vet clinic is also reminding pet owners to regularly check their pets for fleas and ticks. Dr. Windram says that regular spot checks and medication are the best way to keep pets free from fleas and ticks this summer. (Source: Medical News (via PRIMEZONE))

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Thursday 13 June 2013

Nanotube sensor detects Lyme disease

Transistor-based device could rival traditional immunoassays (Source: PhysicsWeb News)


Thursday 13 June 2013

Nanotube transistors detect Lyme disease

Technique could rival traditional ELISA and Western blot immunoassays. (Source: Nanotechweb.org News)


Thursday 13 June 2013

Summer's Mystery Malady

Inside the Lyme epidemic. By Pamela Weintraub (Source: Psychology Today)


Wednesday 12 June 2013

Influence of MKP medium stored for prolonged periods on growth and morphology of Borrelia afzelii, Borrelia garinii, and Borrelia burgdorferi sensu stricto

Modified Kelly‐Pettenkofer (MKP) medium is one of the several media used for isolation and cultivation of Borrelia. The aim of the study was to assess whether particular Borrelia species (B. afzelii, B. garinii, and B. burgdorferi sensu stricto) have the ability to grow in MKP medium stored at +4 °C for periods for 1 month up to 1 year, and how prolonged storage may influences Borrelia growth and morphology. The growth of Borrelia was evaluated after 5 days of incubation at 33 °C: cell count per mL, morphology, and motility were assessed. The results of this study showed that the duration of storage of MKP medium had statistically significant influence on growth of B. afzelii (p = 0.021) and B. garinii (p = 0.004), but not on growth of B. burgdorferi sensu stricto (p = 0.204...


Tuesday 11 June 2013

Treatment Trials for Post-Lyme Disease Symptoms Revisited

Abstract: The authors of 4 National Institutes of Health–sponsored antibiotic treatment trials of patients with persistent unexplained symptoms despite previous antibiotic treatment of Lyme disease determined that retreatment provides little if any benefit and carries significant risk. Two groups recently provided an independent reassessment of these trials and concluded that prolonged courses of antibiotics are likely to be helpful. We have carefully considered the points raised by these groups, along with our own critical review of the treatment trials. On the basis of this analysis, the conclusion that there is a meaningful clinical benefit to be gained from retreatment of such patients with parenteral antibiotic therapy cannot be justified. (Source: The American Journal of Medicine)

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Monday 10 June 2013

A Call to Order at the Spirochetal Host‐Pathogen Interface

Summary As the Lyme disease spirochete Borrelia burgdorferi shuttles back and forth between arthropod vector and vertebrate host, it encounters vastly different and hostile environments. Major mechanisms contributing to the success of this pathogen throughout this complex transmission cycle are phase and antigenic variation of abundant and serotype‐defining surface lipoproteins. These peripherally membrane‐anchored virulence factors mediate niche‐specific interactions with vector/host factors and protect the spirochete from the perils of the mammalian immune response. In this issue of Molecular Microbiology, Tilly, Bestor and Rosa redefine the roles of two lipoproteins, OspC and VlsE, during mammalian infection. Using a variety of promoter fusions in combination with a sensitive in v...


Monday 10 June 2013

Lyme disease spirochaetes possess an aggrecan‐binding protease with aggrecanase activity

Summary Connective tissues are the most common area of colonization for the Lyme disease spirochaete Borrelia burgdorferi. Colonization is aided by the interaction between numerous bacterial adhesins with components of the extracellular matrix (ECM). Here we describe a novel interaction between B. burgdorferi and the major ECM proteoglycan found in joints, aggrecan. Using affinity chromatography and mass spectrometry we identify two borrelial aggrecan‐binding proteins: the known ECM ligand Bgp (BB0588) and an uncharacterized protease BbHtrA (BB0104). Proteinase K studies demonstrate that BbHtrA is surface exposed. Immunoblots using sera from patients with both early and late Lyme disease establish that BbHtrA is expressed during human disease, immunogenic, and conserved in the three ma...


Sunday 9 June 2013

Epidemiology of Lyme disease among workers of forest inspectorates in Poland.

Conclusions. LB occurs more frequently among foresters older in age and with longer service (45%); in the younger group - 30%. Despite knowledge on preventive methods, there is no effective preventive method for this disease. PMID: 23772586 [PubMed - in process] (Source: Annals of Agricultural and Environmental Medicine : AAEM)


Sunday 9 June 2013

Association between incidence of Lyme disease and spring-early summer season temperature changes in Hungary - 1998-2010.

Authors: Trájer A, Bobvos J, Páldy A, Krisztalovics K Abstract The increase of Lyme borreliosis (LB) can be expected due to climate change, while the distribution of the disease and annual activity of the vector and host animals depend on several factors of the environment. The presented study aimed to assess expressly the spring season temperature dependence on the incidence of LB in Hungary. The weekly LB data were obtained from the National Epidemiologic and Surveillance System for a period of 13 years - 1998-2010. Daily temperature data were derived from the European Climate Assessment and Dataset. The association was studied at national level, descriptive statistics and linear regression models were applied. A significant increasing trend was observed in the mean temperature...


Friday 7 June 2013

Straw men don't get Lyme disease: response to Wood and Lafferty.

Authors: Ostfeld RS, Keesing F PMID: 23747005 [PubMed - as supplied by publisher] (Source: Trends in Ecology and Evolution)

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Tuesday 4 June 2013

The Dos and Don'ts of Summer Fun

The school year may be almost over, but that doesn’t mean you should adopt a school’s-out attitude when it comes to your health. Regardless of your plans, heed these simple dos and don’ts to ensure you get a passing grade. At the Park DO outsmart the bugs. Wear light-colored, breathable clothing—you’ll be less attractive to bees, which like bright colors. Light colors also make it easier to spot ticks. If you’re planning to be outside for an extended time, spray your clothes, not your skin, with a bug repellent that contains DEET. If you are stung or plagued with insect bites, ice the swollen area, says Meredith Barbour, MD, a family physician at Duke Primary Care Brier Creek. An over-the-counter antihistamine will help reduce the swelling and the itching. DON’T ignore your...


Monday 3 June 2013

An insect bite on holiday put Sarah in a wheelchair. Africa? India? No, right here in Britain...

On a walking holiday in the UK, Sarah Bignell caught Lyme disease, an illness that caused her so much pain she was bedridden for weeks. (Source: the Mail online | Health)


Saturday 1 June 2013

Lyme Disease: From Early Localized Disease to Post-Lyme Disease Syndrome

This article provides nurse practitioners with the necessary information to diagnose and treat patients with Lyme disease, from early infection to post-Lyme disease syndrome. (Source: The Journal for Nurse Practitioners)


Saturday 1 June 2013

[In Process Citation].

We report a case of an 88-year old male patient with known chronic lower back pain who presented in late August with progressive pain in his right knee and lower leg as well as paraesthesias. Diagnostic work-up revealed an acute Lyme-Borreliosis. PMID: 23735767 [PubMed - in process] (Source: Praxis)


Friday 31 May 2013

Lyme Chondritis Presenting as Painless Ear Erythema

Erythema of the ear lobe in the context of Lyme disease is caused by either borrelial lymphocytoma or localized erythema migrans. Here we present a case of chondritis limited to the ear cartilage caused by Lyme disease. The patient was treated with ceftriaxone with complete resolution of symptoms. (Source: PEDIATRICS)

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Friday 31 May 2013

What's contributing to the spread of valley fever?

Valley fever, caused by soil fungus in Calif. and Ariz., has become a bigger threat than West Nile virus and Lyme disease (Source: Health News: CBSNews.com)


Thursday 30 May 2013

Lyme Disease Update for Maine Healthcare Providers Lyme Disease Update for Maine Healthcare Providers

As the temperature increases, so does the number of reported Lyme disease cases in Maine. State Health Alerts (Source: Medscape Today Headlines)


Thursday 30 May 2013

Dysregulation of CD4+CD25high T Cells in the Synovial Fluid of Patients With Antibiotic‐Refractory Lyme Arthritis

ConclusionPatients with antibiotic‐refractory Lyme arthritis often have lower frequencies of Treg cells, higher expression of activation coreceptors, and less effective inhibition of proinflammatory cytokines. This suggests that immune responses in these patients are excessively amplified, leading to immune dysregulation and antibiotic‐refractory arthritis. (Source: Arthritis and Rheumatism)


Monday 27 May 2013

Lyme disease spirochetes possess an aggrecan‐binding protease with aggrecanase activity

Summary Connective tissues are the most common area of colonization for the Lyme disease spirochete Borrelia burgdorferi. Colonization is aided by the interaction between numerous bacterial adhesins with components of the extracellular matrix (ECM). Here we describe a novel interaction between B. burgdorferi and the major ECM proteoglycan found in joints, aggrecan. Using affinity chromatography and mass spectrometry we identify two borrelial aggrecan‐binding proteins: the known ECM ligand Bgp (BB0588) and an uncharacterized protease BbHtrA (BB0104). Proteinase K studies demonstrate that BbHtrA is surface exposed. Immunoblots using sera from patients with both early and late Lyme disease establish that BbHtrA is expressed during human disease, immunogenic, and conserved in the three major...


Sunday 26 May 2013

Heart stopping tick.

Authors: Karmacharya P, Aryal MR Abstract Although Lyme carditis is relatively rare within 4-6 wk of exposure, it can uncommonly present as the first sign of disseminated Lyme disease. Here we present 17 year old boy who presented to the emergency department with chest discomfort and was later found to have complete atrioventricular block due to lyme carditis. He had uneventful recovery after empiric treatment with ceftriaxone. Our case highlights the importance of considering reversible causes of complete AV block since appropriate therapy can avoid the need for permanent pacemaker insertion. PMID: 23710302 [PubMed - as supplied by publisher] (Source: World Journal of Cardiology)

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Friday 24 May 2013

Video: Lyme disease: What you need to know about ticks

The number of Lyme disease cases have tripled in the past 20 years. Dr. Holly Phillips discusses why the number of cases has skyrocketed, how the disease is transmitted via ticks, and what myths and realities persist about the insects and the disease. (Source: Health News: CBSNews.com)


Friday 24 May 2013

Red fingers syndrome in a patient with pseudolymphoma

To the Editor: A 31-year-old woman presented with a 10-year history of erythematous plaques on the face consistent with cutaneous pseudolymphoma. She incidentally was noted to also have dusky discoloration of her distal fingers and hypothenar eminences bilaterally (), but not toes, and without associated pain, numbness, or accentuation in the cold. Onycholysis was noted on several fingernails, but clubbing or periungual telangiectasias were not present. The patient related that the redness was not present at birth and appeared during her adult years before her pseudolymphoma lesions. She also noted that the redness appeared on the fingers and palms simultaneously and did not wax and wane. She was not using any prescribed or over-the-counter medications at the time of onset or at presentati...


Thursday 23 May 2013

ErpC, a member of the complement regulator-acquiring family of surface proteins from Borrelia burgdorferi, possesses an architecture previously unseen in this protein family

Borrelia burgdorferi is a spirochete responsible for Lyme disease, the most commonly occurring vector-borne disease in Europe and North America. The bacterium utilizes a set of proteins, termed complement regulator-acquiring surface proteins (CRASPs), to aid evasion of the human complement system by recruiting and presenting complement regulator factor H on its surface in a manner that mimics host cells. Presented here is the atomic resolution structure of a member of this protein family, ErpC. The structure provides new insights into the mechanism of recruitment of factor H and other factor H-related proteins by acting as a molecular mimic of host glycosaminoglycans. It also describes the architecture of other CRASP proteins belonging to the OspE/F-related paralogous protein family and su...


Thursday 23 May 2013

Further structural insights into the binding of complement factor H by complement regulator-acquiring surface protein 1 (CspA) of Borrelia burgdorferi

Borrelia burgdorferi has evolved many mechanisms of evading the different immune systems across its range of reservoir hosts, including the capture and presentation of host complement regulators factor H and factor H-like protein-1 (FHL-1). Acquisition is mediated by a family of complement regulator-acquiring surface proteins (CRASPs), of which the atomic structure of CspA (BbCRASP-1) is known and shows the formation of a homodimeric species which is required for binding. Mutagenesis studies have mapped a putative factor H binding site to a cleft between the two subunits. Presented here is a new atomic structure of CspA which shows a degree of flexibility between the subunits which may be critical for factor H scavenging by increasing access to the binding interface and allows the possibil...


Wednesday 22 May 2013

Assessment of the frequency of different Borrelia burgdorferi sensu lato species in patients with Lyme borreliosis from north-east Poland by studying preferential serologic response and DNA isolates.

CONCLUSIONS: Both methods gave consistent results, indicating B.afzelii as the main agent of all the clinical forms of the Lyme borreliosis in the study area. PMID: 23540208 [PubMed - in process] (Source: Annals of Agricultural and Environmental Medicine : AAEM)

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Monday 20 May 2013

Equine Lyme Disease

Abstract: Borrelia burgdorferi infection in horses is common in some areas of North America, but the incidence of clinical disease has not been determined, which makes Lyme disease controversial in the horse. Progress is being made case by case in defining the several clinical presentations of Lyme disease in adult horses. Current serologic tests are very sensitive and specific for detecting either infection (previous or concurrent) or exposure but may not distinguish between them. Treatment protocols are available for Lyme disease in horses; however, the ability of those protocols to eliminate the organism remains questionable. Currently, minocycline is being attempted in some presumed Lyme cases as an improved alternative to doxycycline and oxytetracycline. Vaccination, like many aspects...


Thursday 16 May 2013

Tick-Borne Diseases—Lyme Disease, Anaplasmosis, Piroplasmosis

Exposure to ticks is becoming ever increasingly more frequent as our equine populations are living in closer proximity to wildlife, wildlife populations are changing, and winters are trending less cold . In addition, clients are increasingly well informed with information from the internet, meaning practitioners need to be equipped with the most recent information on tick-borne diseases. (Source: Journal of Equine Veterinary Science)


Thursday 16 May 2013

Experience of Lyme disease and preferences for precautions: a cross-sectional survey of UK patients

Conclusions: The results suggest that the risk of LD is set in the context of the restorative benefits of countryside practices, and that it may be counterproductive to overemphasize pre- or during-visit precautions. Simultaneously, having experienced LD is not associated with any withdrawal from countryside. (Source: BMC Public Health - Latest articles)


Wednesday 15 May 2013

Subject Index

Acute cerebellar ataxia in a pediatric case of Lyme disease and a review of literature, 407 Acute disseminated encephalomyelitis associated with acute Toxoplasma gondii infection, 236 (Source: Pediatric Neurology)


Wednesday 15 May 2013

Structure of an outer surface lipoprotein BBA64 from the Lyme disease agent Borrelia burgdorferi which is critical to ensure infection after a tick bite

In this study, the crystal structure of BBA64 was also compared with that of the paralogous protein CspA (also referred to as BbCRASP-1, CRASP-1 or BBA68). CspA is the complement regulator-acquiring surface protein-1 of B. burgdorferi; its structure is known, but its function apparently differs from that of BBA64. It is demonstrated that unlike the homologous CspA, BBA64 does not form a homodimer. Their differences in function could be explained by divergence in their amino-acid sequences, electrostatic surface potentials and overall tertiary structures. The C-terminal part of BBA64 has a different conformation to that of CspA; the conformation of this region is essential for the proper function of CspA. (Source: Acta Crystallographica Section D)

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Tuesday 14 May 2013

Potential Lyme Disease Vaccine Shows Promise

A vaccine for Lyme disease may be on its way, following a promising phase 1/2 clinical trial from investigators at the Stony Brook University School of Medicine and Brookhaven National Laboratory. The finding was published online in The Lancet Infectious Diseases, and revealed that the vaccine resulted in significant antibodies against all targeted species of Borrelia - the agent that causes Lyme disease in the United States and Europe... (Source: Health News from Medical News Today)


Sunday 12 May 2013

Lyme disease ignorance 'costs lives'

'My long-term Lyme disease pain' (Source: BBC News | Health | UK Edition)


Thursday 9 May 2013

Wisconsin Prepares for Another Active Season of Tickbourne Disease

Wisconsin’s warm spring weather will mean more blacklegged tick activity, and state officials are urging people to take precautions against tick bites when spending time outdoors. Infected blacklegged ticks (also known as deer ticks) carry pathogens that cause Lyme disease and other tickborne diseases. (Source: Wisconsin DHFS Press Releases)


Wednesday 8 May 2013

It's Spring--Time to Prevent Lyme Disease

Source: Centers for Disease Control and Prevention Related MedlinePlus Page: Lyme Disease (Source: MedlinePlus Health News)


Tuesday 7 May 2013

The use of deer vehicle accidents as a proxy for measuring the degree of interaction between human and deer populations and its correlation with the incidence rate of Lyme disease - Wiznia DH, Christos PJ, LaBonte AM.

The study described in this article examined the relationship between the incidence rate of deer vehicle accidents (DVAs), a proxy for measuring the interaction between populations of humans and deer, and human Lyme disease incidence rate. The authors also... (Source: SafetyLit: All (Unduplicated))

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Tuesday 7 May 2013

Influence of arthritis-related protein (BBF01) on infectivity of Borrelia burgdorferi B31

Conclusion: These results indicated that deletion of BBF01/arp did not abrogate, but diminished infectivity and limited spirochete burdens in tissues of both immunocompetent and immunodeficient hosts, and attenuated, but did not abolish the ability of ticks to acquire or transmit infection. (Source: BMC Microbiology - Latest articles)


Thursday 2 May 2013

No link found between autism and Lyme disease

NEW YORK, May 1 (UPI) -- U.S. researchers say they found no link between autism spectrum disorders and biomarkers for Lyme disease. (Source: Health News - UPI.com)


Wednesday 1 May 2013

Lyme Disease Alert for Maine Healthcare ProvidersLyme Disease Alert for Maine Healthcare Providers

Lyme disease is the most common vector-borne disease in Maine. Ticks are already out and we expect the number of Lyme disease cases to increase as the weather continues to get warmer. State Health Alerts (Source: Medscape Today Headlines)


Wednesday 1 May 2013

Lipoprotein succession in Borrelia burgdorferi: Similar but distinct roles for OspC and VlsE at different stages of mammalian infection

In this study, we assessed whether vlsE and ospA could restore infectivity to an ospC mutant, and found that neither gene product effectively compensated for the absence of OspC during early infection. In contrast, we determined that OspC production was required by B. burgdorferi throughout SCID mouse infection if the vlsE gene were absent. Together, these results indicate that OspC can substitute for VlsE when antigenic variation is unnecessary, but that these two abundant lipoproteins are optimized for their related but specific roles during early and persistent mammalian infection by B. burgdorferi. (Source: Molecular Microbiology)


Tuesday 30 April 2013

Study Debunks Lyme Disease-Autism Link

Children with autism no likelier than others to have signs of tick-borne infection (Source: WebMD Health)

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Tuesday 30 April 2013

Lyme Disease, Autism Link Debunked

(MedPage Today) -- A new study has found no evidence of an association between Lyme disease and autism. (Source: MedPage Today Pediatrics)


Friday 26 April 2013

[Acute transverse myelitis and Lyme borreliosis: A case report.]

We present here the case of a 16-year-old teenager with acute myelitis and meningeal involvement due to Lyme disease, who presented with atypical symptoms (massive and rapid weight loss, vomiting). MRI showed localized marrow edema as well as leptomeningeal and root enhancement. Lumbar puncture showed lymphocytic pleocytosis. Lyme serology was positive both in blood and cerebrospinal fluid. Even if acute myelitis remains exceptional among neuroborreliosis manifestations, this diagnosis has to be thought of when a child presents with unexplained neurological symptoms. PMID: 23628118 [PubMed - as supplied by publisher] (Source: Archives de Pediatrie)


Tuesday 23 April 2013

Orchestration of Inflammation and Adaptive Immunity in Borrelia burgdorferi–Induced Arthritis by Neutrophil‐Activating Protein A

ConclusionWe provide evidence that NapA functions as one of the main bacterial products involved in the pathogenesis of LA. Accordingly, we show that, at very early stages of LA, NapA accumulates and, in turn, orchestrates the recruitment of inflammatory cells into the joint cavity. Thereafter, with the contribution of recruited cells, NapA promotes the infiltration of T cells producing IL‐17 and/or IFNγ. (Source: Arthritis and Rheumatism)


Monday 22 April 2013

Seropositivity rates for agents of canine vector-borne diseases in Spain: a multicentre study

This study determines seropositivity rates in Spain for agents causing the following five CVBD using two commercial in-clinic enzyme-linked immunosorbent assay kits: leishmaniosis, heartworm, ehrlichiosis, anaplasmosis and Lyme disease. Image: CVBD prevalences recorded for seven Spanish geographical regions. (Source: Parasites and Vectors)

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Saturday 20 April 2013

Lyme borreliosis and skin

Biju Vasudevan, Manas ChatterjeeIndian Journal of Dermatology 2013 58(3):167-174Lyme disease is a multisystem illness which is caused by the strains of spirochete Borrelia burgdorferi sensu lato and transmitted by the tick, Ixodes. Though very commonly reported from the temperate regions of the world, the incidence has increased worldwide due to increasing travel and changing habitats of the vector. Few cases have been reported from the Indian subcontinent too. Skin manifestations are the earliest to occur, and diagnosing these lesions followed by appropriate treatment, can prevent complications of the disease, which are mainly neurological. The three main dermatological manifestations are erythema chronicum migrans, borrelial lymphocytoma and acrodermatitis chronica atrophicans. Many othe...


Friday 19 April 2013

Lyme Disease Rates Are Rising In Northern U.S.

The number of Lyme disease cases in northern U.S. states is rising, while southern states are experiencing a significant decrease in cases, according to a new study. The research was conducted by a team at the University of Toronto who used data on Lyme disease rates between 1992 and 2007 taken from the CDC (Centers for Disease Control and Prevention) and was published in the journal CMAJ Open. The incidence of this tick-borne disease has risen by about 80% in the U.S., according to the experts, however, rates differ between states... (Source: Health News from Medical News Today)


Friday 19 April 2013

Climate change linked to US Lyme disease spread

Researchers have found that over the past 20 years, the incidence of Lyme disease has increased in the northern-most states of the USA, while declining in more southerly states. (Source: MedWire News - Infectious Diseases)


Thursday 18 April 2013

Acute Cerebellar Ataxia in a Pediatric Case of Lyme Disease and a Review of Literature

We report the case of a 5-year-old girl seropositive for antibodies against the causative Lyme disease pathogen Borrelia burgdorferi presenting with severe acute cerebellar ataxia from the in southern coast of Anatolia (Mediterranean region). (Source: Pediatric Neurology)

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Thursday 18 April 2013

Lyme Disease Rate Increasing in the Northern United StatesLyme Disease Rate Increasing in the Northern United States

Lyme disease incidence increased in the northern-most states in the United States, perhaps because of a climate-change-associated movement of ticks from warmer areas into more northern latitudes. Medscape Medical News (Source: Medscape Medical News Headlines)


Monday 15 April 2013

Hierarchical and Spatially Explicit Clustering of DNA Sequences with BAPS Software

Phylogeographical analyses have become commonplace for a myriad of organisms with the advent of cheap DNA sequencing technologies. Bayesian model-based clustering is a powerful tool for detecting important patterns in such data and can be used to decipher even quite subtle signals of systematic differences in molecular variation. Here, we introduce two upgrades to the Bayesian Analysis of Population Structure (BAPS) software, which enable 1) spatially explicit modeling of variation in DNA sequences and 2) hierarchical clustering of DNA sequence data to reveal nested genetic population structures. We provide a direct interface to map the results from spatial clustering with Google Maps using the portal http://www.spatialepidemiology.net/ and illustrate this approach using sequence data from...


Monday 15 April 2013

Enteroviral Testing and Length of Hospital Stay for Children Evaluated for Lyme Meningitis

Conclusions: Rapid EV PCR testing could assist clinical decision making by Emergency Physicians, avoiding potentially unnecessary hospitalization and parenteral antibiotics for children at low risk of Lyme meningitis. (Source: The Journal of Emergency Medicine)


Monday 15 April 2013

Ecological factors that determine Ixodes ricinus tick burdens in the great tit (Parus major), an avian reservoir of Borrelia burgdorferi s.l.

We present a risk model that explains the levels of infestation of Ixodes ricinus, the main vector of Borrelia burgdorferi s.l., during the breeding season of the great tit (Parus major), one of Europe's most abundant avian reservoir hosts of B. burgdorferi s.l. Tit tick burden were modelled as a function of variables summarising vegetation, climate, proxies for mammal abundance and characteristics of individual birds and their nests. Tick loads were positively associated with the relative humidity prior to capture of the bird and the cover of bracken inside its territory. The number of cold winter days prior to the bird's breeding season showed a negative association with tick loads. None of the proxies for mammal abundance correlated with tick loads. Tick loads decreased with age in fema...


Saturday 13 April 2013

Waxing and Waning Lymphadenopathy

A previously healthy, 48-year-old white man presented with episodes of waxing and waning lymphadenopathy involving the neck, axillae, and groin of 3 years' duration. Each episode occurred on an average every 6 months, lasted approximately 2 weeks, and resolved spontaneously. The patient had malaise associated with these episodes but denied fevers, excessive sweating, or weight loss. Multiple mobile, nontender, firm, 1- to 2-cm lymph nodes were palpable during each of these episodes. He had normal blood counts and had undergone extensive infectious workup in the past for these symptoms. Human immunodeficiency virus, cytomegalovirus, hepatitis, and fungal serologies were negative. Chest x-ray was normal, and tuberculin test result was negative. Epstein-Barr virus antibody panel was positive ...

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Friday 12 April 2013

[Complete atrio-ventricular block as a first symptom of borreliosis: antibiotic treatment instead of pacemaker implantation].

We present a 46-year-old male patient with complete atrio-ventricular block. A inflammatory etiology was suspected and finally lyme carditis was diagnosed. The conduction abnormalities disappeared with antibiotic treatment and a pacemaker implantation was not needed. Further follow-up of two years was uneventful. PMID: 23575720 [PubMed - in process] (Source: Polish Heart Journal)


Friday 12 April 2013

[Unclassified cardiomyopathy or Lyme carditis? A three year follow-up].

We present the case of a 41 year-old Caucasian woman referred to our hospital with symptoms of fatigue, progressive exertional dyspnoea, supraventricular cardiac arrhythmia, and an enlarged heart revealed on chest radiography. Following an untypical result of transthoracic echocardiography, cardiac magnetic resonance was performed. This showed structural cardiac changes and focus of late gadolinium enhancement in the midwall of the apex region. Further diagnostic processes, including endomyocardial biopsy and serology tests, made it possible to diagnose Lyme carditis. Clinical observation was followed-up for three years. PMID: 23575786 [PubMed - in process] (Source: Polish Heart Journal)


Tuesday 9 April 2013

The HtrA protease of Borrelia burgdorferi degrades outer membrane protein BmpD and chemotaxis phosphatase CheX

Summary Borrelia burgdorferi, the spirochaetal agent of Lyme disease, codes for a single HtrA protein, HtrABb (BB0104) that is homologous to DegP of Escherichia coli (41% amino acid identity). HtrABb shows physical and biochemical similarities to DegP in that it has the trimer as its fundamental unit and can degrade casein via its catalytic serine. Recombinant HtrABb exhibits proteolytic activity in vitro, while a mutant (HtrABbS198A) does not. However, HtrABb and DegP have some important differences as well. Native HtrABb occurs in both membrane‐bound and soluble forms. Despite its homology to DegP, HtrABb could not complement an E. coli DegP deletion mutant. Late stage Lyme disease patients, as well as infected mice and rabbits developed a robust antibody response to HtrABb, indica...


Monday 8 April 2013

Natural Protection Against Lyme borreliosis Found In Wild Mice

Springtime spells tick-time. Lyme borreliosis is the most common tick-borne disease in Switzerland: around 10,000 people a year become infected with the pathogen. The actual hosts for Borrelia, however, are wild mice. Like in humans, the pathogen is also transmitted by ticks in mice. Interestingly, not all mice are equally susceptible to the bacterium and individual animals are immune to the pathogen. Scientists from the universities of Zurich and Lund headed by evolutionary biologist Barbara Tschirren reveal that the difference in vulnerability among the animals is genetic in origin... (Source: Health News from Medical News Today)


Monday 8 April 2013

Tick Bites and Lyme Disease: The Need for Timely Treatment

In the United States, 30,158 people were reported as having contracted Lyme disease during 2010; 96% of the cases in 2011 were reported from 13 northeast and north-central states. Time of tick attachment is a critical factor. Prolonged attachment allows time for a bacterium to move from tick to human. Patient history and meticulous skin inspection are the most important elements used in diagnosis of Lyme disease. The most common drug for treatment is doxycycline. Ticks find their hosts by several senses: odor, moisture, heat, and vibration. Avoidance of tick-infested areas, such as wooded areas and leaf piles, is paramount in preventing Lyme disease. (Source: Critical Care Nursing Clinics of North America)

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Friday 5 April 2013

Role of LBP and CD14 in Lipopeptide Delivery to TLRs 1 and 2 [Lipids]

Bacterial lipoproteins are the most potent microbial agonists for the Toll-like receptor 2 (TLR2) subfamily, and this pattern recognition event induces cellular activation, leading to host immune responses. Triacylated bacterial lipoproteins coordinately bind TLR1 and TLR2, resulting in a stable ternary complex that drives intracellular signaling. The sensitivity of TLR-expressing cells to lipoproteins is greatly enhanced by two lipid-binding serum proteins known as lipopolysaccharide-binding protein (LBP) and soluble CD14 (sCD14); however, the physical mechanism that underlies this increased sensitivity is not known. To address this, we measured the ability of LBP and sCD14 to drive ternary complex formation between soluble extracellular domains of TLR1 and TLR2 and a synthetic triacylate...


Monday 1 April 2013

Pediatric sudden sensorineural hearing loss: Diagnosed causes and response to intervention

Conclusions: The incidence of SSNHL in pediatric patients is unknown. Etiologies of SSNHL include viral, EVA, ototoxicity, noise, and non-organic. Most studies were non-diagnostic although 2/22 CT/MRI provided an etiology. Identification of other causes required careful history review. The incidence of SSNHL in the pediatric population needs to be studied, and the timing, dosage, route and efficacy of steroids further evaluated. (Source: International Journal of Pediatric Otorhinolaryngology)


Monday 1 April 2013

[Articles] Global economic burden of Chagas disease: a computational simulation model

The economic burden of Chagas disease is similar to or exceeds those of other prominent diseases globally (eg, rotavirus $2·0 billion, cervical cancer $4·7 billion) even in the USA (Lyme disease $2·5 billion), where Chagas disease has not been traditionally endemic, suggesting an economic argument for more attention and efforts towards control of Chagas disease. (Source: The Lancet Infectious Diseases)


Monday 1 April 2013

Protein-losing nephropathy associated with Borrelia burgdorferi seropositivity in a soft-coated wheaten terrier: Response to therapy.

Authors: Horney BS, Stojanovic V Abstract A soft-coated wheaten terrier was examined for lameness with subsequent identification of protein-losing nephropathy, hypoalbuminemia, hyperglobulinemia, and seroconversion to Borrelia burgdorferi. Following doxycycline therapy, the urine protein loss decreased significantly and serum albumin concentration remained close to or within the reference interval for over 3 years, contrary to the reported poor prognosis for renal disease associated with B. burgdorferi or protein-losing nephropathy of soft-coated wheaten terriers. PMID: 24082169 [PubMed - as supplied by publisher] (Source: The Canadian Veterinary Journal)

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Monday 1 April 2013

Acute Transverse Myelitis in a Child With Lyme Disease and a Review of Literature

We describe here the sixth child with borreliosis-related transverse myelitis. (Source: Pediatric Neurology)


Saturday 30 March 2013

Are you breathing?

Recently I have been learning about breathing. I know, it sounds crazy. I do already know how to breathe, and so do all of my clients. But one workshop with Dr. Richard Brown offers "breathing techniques to relieve stress and improve mood, mental focus, and cardiorespiratory health." I'd like to share this with my clients, but I'm a little hesitant.read more (Source: Psychology Today Depression Center)


Saturday 30 March 2013

Lyme Disease Antibodies Attached To Nanotubes, Paving Way For Diagnostic Device

Early diagnosis is critical in treating Lyme disease. However, nearly one quarter of Lyme disease patients are initially misdiagnosed because currently available serological tests have poor sensitivity and specificity during the early stages of infection. Misdiagnosed patients may go untreated and thus progress to late-stage Lyme disease, where they face longer and more invasive treatments, as well as persistent symptoms. Existing tests assess the presence of antibodies against bacterial proteins, which take weeks to form after the initial infection and persist after the infection is gone... (Source: Health News from Medical News Today)


Thursday 28 March 2013

Federal Register: Establishing the Performance Characteristics of In Vitro Diagnostic Devices for the Detection of Antibodies to Borrelia burgdorferi; Guidance for Industry and Food and Drug Administration Staff; Availability

The FDA is announcing the availability of the guidance entitled "Establishing the Performance Characteristics of In Vitro Diagnostic Devices for the Detection of Antibodies to Borrelia burgdorferi.' FDA is issuing this guidance to provide industry and... (Source: Food and Drug Adminstration (FDA): CDRHNew)


Wednesday 27 March 2013

Guidance for Industry and Food and Drug Administration Staff - Establishing the Performance Characteristics of In Vitro Diagnostic Devices for the Detection of Antibodies to Borrelia burgdorferi

FDA is issuing this guidance to provide industry and agency staff with recommendations for studies to establish the analytical and clinical performance of in vitro diagnostic devices (IVDs) intended for the detection of antibodies to Borrelia burgdorferi. (Source: Food and Drug Adminstration (FDA): CDRHNew)


Tuesday 26 March 2013

Penn Researchers attach Lyme disease antibodies to nanotubes, paving way for diagnostic device

(University of Pennsylvania) Existing Lyme disease tests assess the presence of antibodies, which take weeks to form after the initial infection and persist after the infection is gone. Now, a nanotechnology-inspired technique developed by researchers at the University of Pennsylvania may lead to diagnostics that can detect the organism itself. (Source: EurekAlert! - Medicine and Health)

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Tuesday 26 March 2013

Proteolysis of BB0323 results in two polypeptides that impact physiologic and infectious phenotypes in Borrelia burgdorferi

Summary Borrelia burgdorferi gene product BB0323 is required for cell fission and pathogen persistence in vivo. Here, we show that BB0323, which is conserved among globally prevalent infectious strains, supports normal spirochaete growth and morphology even at early phases of cell division. We demonstrate that native BB0323 undergoes proteolytic processing at the C‐terminus, at a site after the first 202 N‐terminal amino acids. We further identified a periplasmic BB0323 binding protein in B. burgdorferi, annotated as BB0104, having serine protease activity responsible for the primary cleavage of BB0323 to produce discrete N‐ and C‐terminal polypeptides. These two BB0323 polypeptides interact with each other, and either individually or as a complex, are associated with multiple fu...


Monday 25 March 2013

Southern Tick-Associated Rash IllnessSouthern Tick-Associated Rash Illness

Can you tell whether your patient has Lyme or STARI? CDC Expert Commentary (Source: Medscape Today Headlines)


Monday 25 March 2013

Quirky Feature Of Lyme Disease Bacteria Revealed

Scientists have confirmed that the pathogen that causes Lyme Disease - unlike any other known organism - can exist without iron, a metal that all other life needs to make proteins and enzymes. Instead of iron, the bacteria substitute manganese to make an essential enzyme, thus eluding immune system defenses that protect the body by starving pathogens of iron. To cause disease, Borrelia burgdorferi requires unusually high levels of manganese, scientists at Johns Hopkins University (JHU), Woods Hole Oceanographic Institution (WHOI), and the University of Texas reported... (Source: Health News from Medical News Today)


Friday 22 March 2013

B. burgdorferi and Autophagy [Microbiology]

Borrelia burgdorferi sensu lato is the causative agent of Lyme disease. Recent studies have shown that recognition of the spirochete is mediated by TLR2 and NOD2. The latter receptor has been associated with the induction of the intracellular degradation process called autophagy. The present study demonstrated for the first time the induction of autophagy by exposure to B. burgdorferi and that autophagy modulates the B. burgdorferi-dependent cytokine production. Human peripheral blood mononuclear cells treated with autophagy inhibitors showed an increased IL-1β and IL-6 production in response to the exposure of the spirochete, whereas TNFα production was unchanged. Autophagy induction against B. burgdorferi was dependent on reactive oxygen species (ROS) because cells from patients with c...

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Friday 22 March 2013

Manganese and SOD in the Lyme Disease Pathogen [Enzymology]

The Lyme disease pathogen Borrelia burgdorferi represents a novel organism in which to study metalloprotein biology in that this spirochete has uniquely evolved with no requirement for iron. Not only is iron low, but we show here that B. burgdorferi has the capacity to accumulate remarkably high levels of manganese. This high manganese is necessary to activate the SodA superoxide dismutase (SOD) essential for virulence. Using a metalloproteomic approach, we demonstrate that a bulk of B. burgdorferi SodA directly associates with manganese, and a smaller pool of inactive enzyme accumulates as apoprotein. Other metalloproteins may have similarly adapted to using manganese as co-factor, including the BB0366 aminopeptidase. Whereas B. burgdorferi SodA has evolved in a manganese-rich, iron-poor ...


Friday 15 March 2013

Study on public perceptions and protective behaviors regarding Lyme disease among the general public in the Netherlands: implications for prevention programs

Conclusions: Prevention programs targeting tick bites and LD should aim at influencing people's perceptions and increasing their knowledge and perceived efficacy of protective behavior. This can be done by strengthening motivators (e.g. knowledge, concern about LD, perceived efficacy of wearing protective clothing) and removing barriers (e.g. low perceived personal risk, not knowing how to recognize a tick). The challenge is to take our study findings and translate them into appropriate prevention strategies. (Source: BMC Public Health - Latest articles)


Friday 8 March 2013

Primary cutaneous marginal zone lymphoma associated with juxta‐articular fibrotic nodules in a teenager

Primary cutaneous marginal zone lymphoma (PCMZL) has rarely been reported in teenagers and is occasionally associated with Borrelia burgdorferi infection. Juxta‐articular fibrotic nodules represent a unique, localized fibrosing response to spirochete infections, namely Borreliosis. Herein, we report a 15‐year‐old healthy boy who presented with a 4‐year history of progressive acquisition of asymptomatic, erythematous nodules, ≤3 cm, beginning with his right forearm (3), then right arm (1) and lastly his right inner thigh (1). Biopsy showed PCMZL in three of five samples, and inflamed, fibrotic nodules, near the elbow in two. The bottom heavy lymphomatous nodules consisted of mostly small CD20+ CD43+ lymphocytes, some with plasmacytoid features. Mature plasma cells were lambda li...


Tuesday 5 March 2013

Lyme nephritis

ConclusionsThere is no experimental model of LN to study predisposing factors, pathogenesis, onset, progression, treatment, or prevention. There are no predictive tests to identify the few individuals at highest risk, therefore all seropositive dogs should be screened and monitored for proteinuria. Lyme nephritis mimics other forms of protein‐losing nephropathy and sometimes Leptospirosis. Renal biopsy helps show if immune‐complex disease exists, but may not prove LN specifically. More studies are warranted on dogs with Lyme‐specific immune‐complex deposition to evaluate risk factors, understand pathogenesis, variability of expression, and to validate treatment and prevention protocols. (Source: Journal of Veterinary Emergency and Critical Care)


Friday 1 March 2013

Distinguishing Lyme From Septic Knee Monoarthritis in Lyme Disease-Endemic Areas

Children with Lyme and septic arthritis of the knee may present similarly, although septic arthritis requires prompt treatment initiation to avoid joint destruction. Clinicians must make initial management decisions without Lyme serology and bacterial culture results. Our clinical prediction rule accurately identified patients at low risk for septic arthritis in a Lyme disease–endemic area. In the appropriate clinical context, low-risk patients may be spared invasive testing such as diagnostic arthrocentesis. (Read the full article) (Source: PEDIATRICS)


Friday 1 March 2013

Rheumatologists Name 5 Tests to ReconsiderRheumatologists Name 5 Tests to Reconsider

The ACR's part of the Choosing Wisely campaign includes questions about ANA subserology and Lyme disease testing, peripheral joint MRIs, first-line biologics for RA, and frequent DXA scans. Medscape Medical News (Source: Medscape Today Headlines)


Thursday 28 February 2013

Dysregulation of CD4+CD25hi+ T cells in the synovial fluid of patients with antibiotic‐refractory Lyme arthritis

Conclusion.Patients with antibiotic‐refractory Lyme arthritis often had lower frequencies of Treg, higher expression of activation co‐receptors, and less effective inhibition of pro‐inflammatory cytokines. This suggests that immune responses in these patients were excessively amplified leading to immune dysregulation and refractory arthritis. © 2013 American College of Rheumatology. (Source: Arthritis and Rheumatism)


Thursday 28 February 2013

The Many Faces of Solitary and Multiple Erythema Migrans.

In conclusion, multiple erythema migrans may be more common than anticipated, and since only 50% of the patients were seropositive when seeking medi-cal help, PCR testing of skin lesions is helpful to confirm the diagnosis in clinically atypical cases. PMID: 23450303 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)

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Monday 25 February 2013

Development of a foundation for a case definition of post-treatment Lyme disease syndrome

Summary: Objectives: The study objective is to demonstrate the clinical and research utility of an operationalized definition of post-treatment Lyme disease syndrome (PTLDS), as proposed by the Infectious Diseases Society of America.Methods: Seventy-four patients with confirmed erythema migrans and 14 controls were enrolled. Patient-reported symptoms and health function (SF-36) were collected pre-treatment and at follow-up visits over 6 months post-treatment.Results: Eight (11%) patients met our operationalized definition of PTLDS, which included self-reported symptoms of fatigue, widespread musculoskeletal pain or cognitive complaints, and functional impact as measured by a T score of (Source: International Journal of Infectious Diseases)


Sunday 24 February 2013

A Study of the Technique of Western Blot for Diagnosis of Lyme Disease caused by Borrelia afzelii in China.

CONCLUSION: Establishment of WB criteria for B. afzelii is important in validating the diagnostic assays for Lyme disease in China. PMID: 23425802 [PubMed - in process] (Source: Biomedical and Environmental Sciences : BES)


Sunday 24 February 2013

Seroepidemiological Investigation of Lyme Disease and Human Granulocytic Anaplasmosis among People Living in Forest Areas of Eight Provinces in China.

CONCLUSION: We conclude that both pathogens are endemic in the forest areas in the eight provinces, but the prevalence of B. burgdorferi and A. phagocytophilum differs between the provinces. PMID: 23425801 [PubMed - in process] (Source: Biomedical and Environmental Sciences : BES)


Friday 22 February 2013

Tick-Borne Encephalitis and Lyme Disease in Hungary: The Epidemiological Situation Between 1998 and 2008

Vector-Borne and Zoonotic Diseases , Vol. 0, No. 0. (Source: Vector-Borne and Zoonotic Diseases)


Thursday 21 February 2013

Reductions in Human Lyme Disease Risk Due to the Effects of Oral Vaccination on Tick-to-Mouse and Mouse-to-Tick Transmission

Vector-Borne and Zoonotic Diseases , Vol. 0, No. 0. (Source: Vector-Borne and Zoonotic Diseases)

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Thursday 21 February 2013

Choosing wisely: The American College of Rheumatology's top 5 list of things physicians and patients should question

ConclusionThe ACR Top 5 list is intended to promote discussions between physicians and patients about health care practices in rheumatology whose use should be questioned and to assist rheumatologists in providing high‐value care. (Source: Arthritis Care and Research)


Wednesday 20 February 2013

Borrelia Miyamotoi - New Tick Transmitted Disease in North America

Hunterdon Medical Center Physician Successfully Treats First Confirmed Case of Borrelia Miyamotoi - Joseph Gugliotta, M.D.; Anne Felix; Anthony Suarez, MLT (ASCP), Senior Laboratory Technician at Hunterdon Medical Center; and Amy Kurynow, MLT (ASCP), Senior Laboratory Technician at Hunterdon Medical Center. Suarez and Kurynow called attention to the spirochetes during the analysis of the fluid sample from Ms. Felix. (Source: Disabled World)


Wednesday 20 February 2013

Septic Arthritis in Children Ruled Out by New Test Septic Arthritis in Children Ruled Out by New Test

Children with knee arthritis who are from Lyme-disease-endemic areas rarely have septic arthritis and can be spared invasive testing if they meet ANC and ESR criteria. Medscape Medical News (Source: Medscape Today Headlines)


Tuesday 19 February 2013

Distribution of Borrelia burgdorferi sensu lato in Ixodes ricinus Populations Across Central Britain

Vector-Borne and Zoonotic Diseases , Vol. 0, No. 0. (Source: Vector-Borne and Zoonotic Diseases)


Tuesday 19 February 2013

Elevated Lyme Disease Seroprevalence Among Dogs in a Nonendemic County: Harbinger or Artifact?

Vector-Borne and Zoonotic Diseases , Vol. 0, No. 0. (Source: Vector-Borne and Zoonotic Diseases)

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Tuesday 19 February 2013

Lyme disease and the heart.

Authors: Krause PJ, Bockenstedt LK PMID: 23429899 [PubMed - in process] (Source: Circulation)


Sunday 17 February 2013

Why has Borrelia burgdorferi not been transmitted by blood transfusion?

Authors: Ginzburg Y, Kessler D, Kang S, Shaz B, Wormser GP PMID: 23414144 [PubMed - as supplied by publisher] (Source: Transfusion)


Thursday 14 February 2013

A Tale of Two Eyes (P02.187)

CONCLUSIONS: Isolated bilateral sixth nerve palsy has been described in the literature and its incidence is almost equal to unilateral sixth nerve palsy. The most common causes are tumors and demyelinating lesions. Miller fisher syndrome classically presents with a triad of ataxia, opthalmoplegia and areflexia . It may present only as acute ophthalmoperesis, however this has been described in very few case reports. Rarely is the presentation isolated bilateral sixth nerve palsy as seen in our patient. It is hypothesized that infection by microorganism expressing GQ1b epitope triggers production of IgG anti-GQ1b antibodies. These antibodies bind to GQ1b, which are highly expressed on occulomotor nerves and group 1a muscle spindles. This condition has a self-limited course and seldom causes ...


Thursday 14 February 2013

Movement Disorder as the Clinical Presentation of Porphyria: A Case Report (P03.056)

CONCLUSIONS: We must be aware of other possible clinical presentations of porphyria to initiate treatment early and diminish complications related to the disease.Disclosure: Dr. Rundle-Gonzalez has nothing to disclose. Dr. Huang has nothing to disclose. (Source: Neurology)


Thursday 14 February 2013

The tick that stopped the ticker

A 31 year old healthy male was brought to emergency department after he collapsed while attending a bingo tournament. He denied any chest pain, shortness of breath or palpitations. The witnesses of event reported no incontinence, tongue bite or jerky movements of body. Patient had no recollection of event and was asymptomatic at presentation. Patient reported being in the woods for last few days and developing malaise and generalized weakness 3days prior to this event. The patient was awake, alert and oriented to time, place and person. His vital signs and cardiovascular examination were unremarkable. His laboratory data revealed a normal cell count, electrolyte panel, thyroid functions and troponin-I. Urine examination was normal. His ECG showed () complete AV dissociation with an acceler...

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Wednesday 13 February 2013

Ixodes ricinus ticks infected with the causative agent of Lyme disease, Borrelia burgdorferi sensu lato, have higher energy reserves.

Authors: Herrmann C, Voordouw MJ, Gern L Abstract Ticks use their energy reserves to maintain their water balance, search for hosts and transmit tick-borne pathogens. However, the influence of tick-borne pathogens on the energy reserves of the tick vector has not been well studied. The relationship between Borrelia burgdorferi sensu lato (s.l.) infection status and fat content in questing Ixodes ricinus nymphs was examined. Nymphs were sampled from the field. Their body mass and fat content were measured, and their Borrelia genospecies infection status (using reverse line blot analysis), and spirochete load (using quantitative PCR) were analysed. Of the 900 nymphs tested, 21.2% were infected with a variety of Borrelia genospecies. Borrelia-infected nymphs had 12.1% higher fat conte...


Wednesday 13 February 2013

Borrelia burgdorferi sensu lato Infecting Ticks of the Ixodes ricinus Complex in Uruguay: First Report for the Southern Hemisphere

Vector-Borne and Zoonotic Diseases , Vol. 0, No. 0. (Source: Vector-Borne and Zoonotic Diseases)


Thursday 7 February 2013

New study highlights Chagas disease as a growing health and socio-economic challenge

(Sabin Vaccine Institute) Today, The Lancet Infectious Diseases published a new report that examines the global economic burden of Chagas disease. In the first study of its kind, researchers measured the health and economic impact of Chagas disease and found that the total economic burden of Chagas disease matches or exceeds that of many more well-known diseases such as rotavirus, Lyme disease and cervical cancer. (Source: EurekAlert! - Social and Behavioral Science)


Friday 1 February 2013

"Making Lemonade" out of Lyme.

"Making Lemonade" out of Lyme. Pediatr Ann. 2013 Feb 1;42(2):57-60 Authors: Block SL PMID: 23379407 [PubMed - in process] (Source: Pediatric Annals)


Friday 1 February 2013

Borrelia host adaptation Regulator (BadR) regulates rpoS to modulate host adaptation and virulence factors in Borrelia burgdorferi.

Summary The RpoS transcription factor of Borrelia burgdorferi is a “gatekeeper” because it activates genes required for spirochetes to transition from tick to vertebrate hosts. However, it remains unknown how RpoS becomes repressed to allow the spirochetes to transition back from the vertebrate host to the tick vector. Here we show that a putative carbohydrate‐responsive regulatory protein, designated BadR (Borrelia host adaptation Regulator), is a transcriptional repressor of rpoS. BadR levels are elevated in B. burgdorferi cultures grown under in vitro conditions mimicking unfed‐ticks and badR‐deficient strains are defective for growth under these same conditions. Microarray and immunoblot analyses of badR‐deficient strains showed up‐regulation of rpoS and other factors imp...

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Friday 1 February 2013

Cutaneous Primary Marginal Zone Lymphoma Associated with Juxta‐Articular Fibrotic Nodules in a Teenager

Abstract Primary cutaneous marginal zone lymphoma (PCMZL) has rarely been reported in teenagers and is occasionally associated with Borrelia burgdorferi infection. Juxta‐articular fibrotic nodules represent a unique, localized fibrosing response to spirochete infections, namely Borreliosis. Herein, we report a 15‐year‐old healthy boy who presented with a 4year history of progressive acquisition of asymptomatic, erythematous nodules, ≤3cm, beginning with his right forearm (3), then right arm (1), and lastly his right inner thigh (1). Biopsy demonstrated PCMZL in 3 of 5 samples, and inflamed, fibrotic nodules, near the elbow in 2. The bottom heavy lymphomatous nodules consisted of mostly small CD20+ CD43+ lymphocytes, some with plasmacytoid features. Mature plasma cells were lambda l...


Thursday 31 January 2013

Orchestration of inflammation and adaptive immunity in Borrelia burgdorferi‐induced arthritis by NapA

Conclusion.Herein, we prove that NapA functions as one of the main bacterial products involved in the pathogenesis of LA. Accordingly, we show that, at very early stages of LA, NapA accumulates and, in turn, orchestrates the recruitment of inflammatory cells into the joint cavity; thereafter, with the contribution of recruited cells, NapA promotes the infiltration of T cells producing IL‐17 and/or IFN‐γ. (Source: Arthritis and Rheumatism)


Wednesday 30 January 2013

Lyme Culture Test Causes UproarLyme Culture Test Causes Uproar

The aggressive marketing of an unvalidated culture test for Borrelia burgdorferi has raised red flags among infectious disease specialists and may lead to more restrictive regulation of such tests. Medscape Medical News (Source: Medscape Today Headlines)


Wednesday 30 January 2013

Tick‐Borne Diseases in the South‐East Need Human Studies: Lyme Disease, STARI and Beyond

(Source: Zoonoses and Public Health)


Wednesday 23 January 2013

Emerging tick-borne disease reaches USA

A new tick-borne infection caused by the spirochete bacteria Borrelia miyamotoi that produces similar symptoms to Lyme disease has been confirmed in a small number of patients in the USA. (Source: MedWire News - Infectious Diseases)

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Tuesday 22 January 2013

Ability to cause erythema migrans differs between Borrelia burgdorferi sensu lato isolates

Borrelia burgdorferi s.l. isolates, distinguished based on IGS and opsC sequences, differ in their propensity to cause erythema migrans. Furthermore, detection of identical ospC types in different genospecies indicates plasmid exchange. Image: Tick in a symbolic bull¿s eye. (Source: Parasites and Vectors)


Monday 21 January 2013

Lyme borreliosis: the need for more research

(Source: QJM)



Monday 21 January 2013

Management of suspected Lyme borreliosis: experience from an outpatient parenteral antibiotic therapy service

Conclusions: These results show the complexity of translating well-substantiated regimens from clinical trials to actual clinical practice. OPAT was an effective way of administering parenteral therapy for Lyme disease but should not be undertaken lightly due to the rate of adverse events and low rates of success in certain patient groups seen in this study. In view of this, stricter criteria for inclusion to OPAT in line with published guidance should be applied to minimize patient harm and optimize success. (Source: QJM)


Sunday 20 January 2013

Prednisone: Aaggravation of Lyme disease in an elderly patient: case report

(Source: Reactions)

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Saturday 19 January 2013

New Tick-Borne Disease Found In The U.S.

A new infection causes by ticks that is extremely similar to Lyme disease has been found in 18 people in southern New England and upstate New York. The unnamed disease has been confirmed in humans for the first time by researchers from Yale University who published their findings in the New England Journal of Medicine. The report suggests that this new sickness could be infecting more than 4,300 Americans a year with flu-like symptoms and relapsing fevers. Luckily, one dosage of antibiotics seems capable of eliminating the disease... (Source: Health News from Medical News Today)


Friday 18 January 2013

Unilateral phrenic nerve lesion in Lyme neuroborreliosis

Conclusion: Although Lyme neuroborreliosis is a rare cause of diaphragmatic weakness, it should be considered in the differential workup because of its potentially treatable nature. (Source: BioMed Central)


Thursday 17 January 2013

U.S. Researchers Find New Disease Carried by Deer TicksU.S. Researchers Find New Disease Carried by Deer Ticks

U.S. scientists have discovered a new deer tick-borne disease in humans, with the viral-like illness sharing similarities both with Lyme disease and relapsing fever infections. Reuters Health Information (Source: Medscape Infectious Diseases Headlines)


Wednesday 16 January 2013

Deer Ticks Carry Yet Another Bacterial Threat

Lyme disease is better known, but a different germ causes an infection that may lead to dementia Source: HealthDay Related MedlinePlus Pages: Dementia, Lyme Disease (Source: MedlinePlus Health News)


Wednesday 16 January 2013

New Tickborne Pathogen Found in U.S. (CME/CE)

(MedPage Today) -- An elderly immunocompromised woman who developed meningoencephalitis was most likely infected with Borrelia miyamotoi, which is related to the spirochete that causes Lyme disease, researchers said. (Source: MedPage Today Geriatrics)

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Wednesday 16 January 2013

Deer Ticks Carry Yet Another Bacterial Threat

People who go outdoors in several regions of the United States may have something else to worry about. Scientists report that there's another troublesome germ hiding in the deer tick that already harbors the Lyme disease bacterium. (Source: RWJF News Digest - Public Health)


Monday 14 January 2013

Common Misconceptions About Lyme Disease

Abstract: Lyme disease, infection with Borrelia burgdorferi, is a focally endemic tick-transmitted zoonosis. During the 3 decades since the responsible spirochete was identified, a series of misconceptions and misunderstandings have become widely prevalent, leading to frequent misdiagnosis and inappropriate treatment. Persistent misconceptions concern the reliability of available diagnostic tools, the signs and symptoms of nervous system involvement, the appropriate choice and duration of antimicrobial therapy, the curability of the infection, and the cause of symptoms that may persist in some patients after treatment. Concern about disparate perspectives led the Institute of Medicine to review the subject. In this article we review the principal misconceptions, discussing their origins a...


Monday 14 January 2013

Rapid progressive bilateral hearing loss due to granulomatous otitis media in Lyme disease

We report on a patient with Lyme disease who presented with chronic bilateral otitis media and cranial neuropathy with rapid progresive hearing loss. After ceftriaxone and high-dose intravenous immunglobulins, the disease was controlled only with methylprednisolone and cyclophosphamide. The relationship between Lyme disease and granulomatous vasculitis is discussed. Lyme disease should be kept in mind in the differential diagnosis of various otolaryngological and neurological presentations. (Source: American Journal of Otolaryngology)


Sunday 13 January 2013

Tick related diseases in Switzerland, 2008 to 2011.

CONCLUSIONS: Tick related diseases are frequent and widespread in Switzerland. They are leading to a considerable usage of the health care system. Thus, tick bite prevention and vaccination against tick borne encephalitis are essential. However, long term follow-up cohort studies with reasonably large study populations after tick bite would be required to elucidate the risk of developing a tick borne disease. PMID: 23299974 [PubMed - in process] (Source: Swiss Medical Weekly)


Saturday 12 January 2013

Recent lesson from a clinical and seroepidemiological survey: low positive predictive value of Borrelia burgdorferi antibody testing in a high risk population.

Conclusion: Positive Borrelia antibody test result may be especially misleading in a high-risk population. PMID: 23314562 [PubMed - as supplied by publisher] (Source: Advances in Medical Sciences)

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Friday 11 January 2013

Chronic Lyme; diagnostic and therapeutic challenges.

Authors: Ljøstad U, Mygland A Abstract In this review, we aim to discuss the definition, clinical and laboratory features, diagnostics, and management of chronic Lyme. Chronic Lyme is a rare condition caused by long-lasting and ongoing infection with the spirochete Borrelia burgdorferi (Bb). The most common manifestations are progressive encephalitis, myelitis, acrodermatitis chronica atrophicans with or without neuropathy, and arthritis. Chronic Lyme is not considered to present with isolated subjective symptoms. Direct detection of Bb has low yield in most manifestations of chronic Lyme, while almost 100% of the cases are seropositive, that is, have detectable Bb IgG antibodies in serum. Detection of Bb antibodies only with Western blot technique and not with ELISA and detection...


Friday 11 January 2013

In vitro susceptibility of European human Borrelia burgdorferi sensu stricto strains to antimicrobial agents

This study is the first report on the antibiotic susceptibility of a series of European human isolates of B. burgdorferi s.s. (Source: International Journal of Antimicrobial Agents)


Friday 11 January 2013

B. burgdorferi and Tick Proteins in the VectorB. burgdorferi and Tick Proteins in the Vector

A greater understanding of vector–pathogen interaction and the identification of tick proteins that are key for survival of B. burgdorferi will help develop effective management for Lyme disease. Future Microbiology (Source: Medscape Today Headlines)


Monday 7 January 2013

Cerebrospinal fluid CXCL13 in Lyme neuroborreliosis and asymptomatic HIV infection

Conclusions: We confirm previous reports of highly elevated CSF CXCL13 levels in LNB patients and that these levels decline after oral doxycycline treatment. The same pattern is seen for CSF mononuclear cells. CSF CXCL13 levels are elevated in neurologically asymptomatic HIV patients and the levels overlap those of LNB patients. The diagnostic value of CSF CXCL13 in LNB remains to be established. (Source: BMC Neurology)


Saturday 5 January 2013

Lyme Borreliosis Spirochetes and Spotted Fever Group Rickettsiae in Ixodid Ticks from Pianosa Island, Tuscany Archipelago, Italy

Vector-Borne and Zoonotic Diseases , Vol. 0, No. 0. (Source: Vector-Borne and Zoonotic Diseases)

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Saturday 5 January 2013

Complement evasion by Borrelia burgdorferi: it takes three to tango.

Authors: de Taeye SW, Kreuk L, van Dam AP, Hovius JW, Schuijt TJ Abstract The complement system is one of the major innate defense mechanisms Borrelia burgdorferi sensu lato has to overcome to establish an infection of mammalian hosts and to cause Lyme borreliosis in humans. Borrelia prevents complement-mediated killing during host colonization through (i) recruitment of host complement regulators by Borrelia, (ii) evasion mechanisms by Borrelia itself, and (iii) exploitation of tick proteins by Borrelia. These interactions with complement can be host species-specific. This review provides an overview of interactions between Borrelia, tick, and host leading to evasion of complement-mediated killing. PMID: 23298533 [PubMed - as supplied by publisher] (Source: Trends in Parasitol...


Thursday 3 January 2013

Refractory Lyme Arthritis May Be Autoimmune (CME/CE)

(MedPage Today) -- Activated T- and B-cell responses to an autoantigen in synovial tissue may explain the development of resistant arthritis among a small number of patients with Lyme disease, researchers suggested. (Source: MedPage Today Infectious Disease)


Monday 31 December 2012

Hypocretin Deficiency Develops During Onset of Human Narcolepsy with Cataplexy

Conclusions:We confirm that hypocretin deficiency develops in parallel to the onset of human narcolepsy with cataplexy.Citation:Savvidou A; Knudsen S; Olsson-Engman M; Gammeltoft S; Jennum P; Palm L. Hypocretin deficiency develops during onset of human narcolepsy with cataplexy. SLEEP 2013;36(1):147-148. (Source: Sleep)


Monday 31 December 2012

Borrelia burgdorferi sensu lato as activators of the complement system in in vitro model.

Conclusions. The results obtained on the basis of the in vitro model can be analysed from the aspect of spirochetes' real contact with a host's organism during the bite of infected ticks. Despite blocking of the alternative pathway, Borrelia initiate the activation cascade regardless of antibodies via the first contact of a host's organism with spirochetes, or in accordance with antibodies during the infection or subsequent contact with bacteria. PMID: 23311781 [PubMed - in process] (Source: Annals of Agricultural and Environmental Medicine : AAEM)


Monday 31 December 2012

Leptospirosis as a tick-borne disease? Detection of [i]Leptospir[/i]a spp. in[i] Ixodes ricinus[/i] ticks in eastern Poland.

In conclusion, this study shows for the first time the presence of Leptospira spp. in Ixodes ticks and marked frequency of the occurrence of these bacteria in ticks. This finding has significant epidemiological implications by indicating the possibility of the transmission of leptospirosis by Ixodes ricinus, the commonest tick species in Europe and most important vector of numerous pathogens. PMID: 23311784 [PubMed - in process] (Source: Annals of Agricultural and Environmental Medicine : AAEM)

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Monday 31 December 2012

Herbert Dorken (1926–2012).

Herbert Dorken was born in Montreal, Canada, on July 7, 1926, and died in Grass Valley, California, on February 18, 2012, at the age of 85. Dorken was a prolific writer, with nearly 100 publications to his credit. He was particularly adept at taking raw health care data that the government had assembled with no apparent interpretation and translating it so that its meaning and implications for health care practice were clear. He strongly believed that the health care system in America, and particularly its mental health system, was in need of extensive reform. At the invitation in the mid- 1980s of the National Academies of Practice, he designed a model health care system that was heralded by many health economists, but it went nowhere because it was not in keeping with either of the two m...


Thursday 27 December 2012

Year in Review: Pieces Added to the Lyme Puzzle

(MedPage Today) -- Final numbers for this year aren't in yet, so we don't know if predictions for the worst year ever for Lyme disease will bear out, but pieces of the larger puzzle continue to fall into place. (Source: MedPage Today Primary Care)


Thursday 27 December 2012

Year in Review: Worst Summer Yet for Lyme Disease?

(MedPage Today) -- The summer of 2012 was predicted to be the worst year ever for Lyme disease in the northeastern U.S., even as researchers made advances in the understanding and treatment of refractory cases. (Source: MedPage Today Primary Care)


Friday 21 December 2012

Functional analysis of Borrelia burgdorferi uvrA in DNA damage protection

(Source: FEMS Microbiology Letters)


Wednesday 19 December 2012

Borrelia burgdorferi and tick proteins supporting pathogen persistence in the vector

Future Microbiology , January 2013, Vol. 8, No. 1, Pages 41-56. (Source: Future Microbiology)

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Tuesday 18 December 2012

LYME HP (Baptisia Tinctoria, Echinacea, Hydrastis Canadensis, Lym D Nosode, Arsenicum Album, Bryonia, Chelidonium Majus) Liquid [Energique, Inc.]

Updated Date: Dec 18, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))


Monday 17 December 2012

Circumstantial evidence for an increase in the total number and activity of borrelia-infected ixodes ricinus in the Netherlands

In The Netherlands, the incidence of Lyme disease has been on the rise since 1994. Here, we investigated whether the abundance of questing Ixodes ricinus infected with the Lyme spirochete has increased concomitantly. Image: Questing female Ixodes ricinus. Courtsey: Hans Smid (http://www.bugsinthepicture.com/). (Source: Parasites and Vectors)


Monday 17 December 2012

One Last Chance For APA To Make DSM 5 Safer

The vigorous opposition to the American Psychiatric Association's approval of DSM-5 suggests that it will lack credibility and will not gain widespread approval. I suggest four ways that DSM-5 can be revised to make it less risky and more usable in clinical practice.read more (Source: Psychology Today Anxiety Center)


Thursday 13 December 2012

Director's Comments: Lyme Disease Recurrence Is a New Infection – Not a Relapse

Listen to the NLM Director's Comments on "Lyme Disease Recurrence Is a New Infection – Not a Relapse". The transcript is also available. Lyme disease’s recurrence is a new infection rather than a relapse, suggests research based on DNA sequencing recently published in the New England Journal of Medicine... (Source: What's New on MedlinePlus)


Thursday 13 December 2012

Relating land cover and spatial distribution of nephropathia epidemica and Lyme borreliosis in Belgium

(Source: International Journal of Environmental Health Research)

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Wednesday 12 December 2012

---

This book is the ideal text for anyone wishing to develop a broad understanding of the subject of neuroimmunology. It is small enough to carry on the train, yet manages to cover a broad range of related topics with a surprising degree of detail. In the first few chapters, it offers an introduction to the basic principles of immunology, neurology and neuroimmunology, instantly making the book accessible to all comers to the field. It uses clever analogies to illustrate basic principles of how the immune and nervous systems interact to maintain health, and to describe how inappropriate levels of regulation can lead to disease. Further chapters go onto discuss some of the prototypical neuroimmunological diseases in detail, offering a structured approach to understanding these conditions. Part...


Monday 10 December 2012

CXCL13 may improve diagnosis in early neuroborreliosis with atypical laboratory findings

Conclusion: CXCL13 is a novel biomarker with high sensitivity and specificity for acute LNB. Our data show, that CXCL13 might be helpful in unclear cases and support the presumption that it might be a valuable tool for treatment monitoring. Anti-OspC antibody negativity is a rare observation, given the need of OspC for infection of the human hosts. Most likely this is due to a lack of sensitivity of OspC immunoblots that are unable to detect rare OspC variants. (Source: BMC Infectious Diseases)


Wednesday 5 December 2012

Baby makes miracle recovery after heart 'swelled to the size of a football'

The valves in Liam Dalgarno’s heart were so narrow that it caused severe pressure on the left side of his heart. The baby from Newcastle-under-Lyme needed risky surgery. (Source: the Mail online | Health)


Wednesday 5 December 2012

Spatial spread and demographic expansion of Lyme borreliosis spirochaetes in Eurasia.

Authors: Vollmer S, Feil EJ, Chu CY, Raper SL, Cao WC, Kurtenbach K, Margos G Abstract The Lyme borreliosis (LB) group of spirochaetes currently comprises 18 named species that vary in their geographic distribution, host specificity and ability to cause disease in humans. In Europe three species are most abundant, Borrelia afzelii, Borrelia garinii and Borrelia valaisiana but only two of these (B. garinii and B. afzelii) are regularly found in Asia as well. A recently published study has shown that Borrelia species associated with birds, such as B. garinii, showed limited geographic structuring between European countries while, the rodent associated species, B. afzelii, showed extensive spatial structuring in Europe. Here, we use multilocus sequence analysis to show that when the w...


Tuesday 4 December 2012

Why some strains of Lyme disease bacteria are common and others are not

(American Society for Microbiology) New clues about the bacteria that cause Lyme disease could lead to a novel strategy to reduce infections, according to a study to be published in mBio on Dec. 4. The study reveals that the immune system of the white-footed mouse, a very common reservoir for the bacteria that causes the disease responds differently to different strains of the bacterium, a finding that will help scientists tweak the animals' immune systems to prevent spread of infection. (Source: EurekAlert! - Infectious and Emerging Diseases)

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Saturday 1 December 2012

Epidemiological and Clinical Features of Three Clustered Cases Co‐Infected with Lyme Disease and Rickettsioses

We reported three related female patients admitted at Beijing Ditan Hospital from October to December 2010. They had similar epidemiological histories. At the beginning, they only got a single diagnosis, respectively, but after specific screenings, the final diagnoses were made. Because arthropods can harbour more than one disease‐causing agent, patients can be infected with more than one pathogen at the same time, so the possibility of co‐infection could be higher than what was thought previously. These observations suggested that clinicians should enhance the complete screening of arthropod‐related infectious diseases so as to make an accurate diagnosis and to avoid diagnostic errors. (Source: Zoonoses and Public Health)


Saturday 1 December 2012

Livid erythematous patches on the trunk in Lyme borreliosis

(Source: JDDG)


Saturday 1 December 2012

[Indolent lymphoma of the ear].

DISCUSSION: CD8+ indolent lymphoma is an entity first described in 2007 and reported in the literature in 15 patients. Lesions are located on the nose or external ear. It comprises a non-epidermotropic proliferation of CD8+ T lymphocytes negative for CD4, CD30, CD56, CD57, granzyme B and perforin. The Mib1 proliferation index is low. This new entity appears neither in the 2005 World Health Organization/European Organization for Research and Treatment of Cancer (WHO/EORTC) classification of cutaneous lymphomas nor in the WHO 2008 Classification of tumours of haematopoietic and lymphoid tissues. Surgical treatment or radiotherapy is sufficient, and unlike aggressive, epidermotropic CD8+ T lymphomas chemotherapy is not required. PMID: 23237280 [PubMed - in process] (Source: Annales de Der...


Friday 30 November 2012

Emerging vector-borne diseases create new public health challenges

(University of California - Santa Cruz) West Nile virus, Lyme disease, dengue fever, and plague are examples of "vector-borne zoonotic diseases," caused by pathogens that naturally infect wildlife and are transmitted to humans by vectors such as mosquitoes or ticks. Land-use change, globalization of trade and travel, and social upheaval are driving the emergence of such diseases in many regions. (Source: EurekAlert! - Infectious and Emerging Diseases)


Thursday 29 November 2012

Chronic Lyme; diagnostic and therapeutic challenges

In this review, we aim to discuss the definition, clinical and laboratory features, diagnostics, and management of chronic Lyme. Chronic Lyme is a rare condition caused by long‐lasting and ongoing infection with the spirochete Borrelia burgdorferi (Bb). The most common manifestations are progressive encephalitis, myelitis, acrodermatitis chronica atrophicans with or without neuropathy, and arthritis. Chronic Lyme is not considered to present with isolated subjective symptoms. Direct detection of Bb has low yield in most manifestations of chronic Lyme, while almost 100% of the cases are seropositive, that is, have detectable Bb IgG antibodies in serum. Detection of Bb antibodies only with Western blot technique and not with ELISA and detection of Bb IgM antibodies without simultaneous det...

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Wednesday 28 November 2012

Zoonotic Transmission of Pathogens by Ixodes ricinus Ticks, Romania.

Authors: Paduraru OA, Buffet JP, Cote M, Bonnet S, Moutailler S, Paduraru V, Femenia F, Eloit M, Savuta G, Vayssier-Taussat M Abstract TO THE EDITOR: The Ixodes ricinus tick is a predominant vector of a large variety of pathogens of veterinary and medical consequence in Europe (1). The most prevalent I. ricinus-borne infection of persons in Europe is Lyme borreliosis, a multisystemic disorder caused by spirochetes of the Borrelia burgdorferi sensu lato complex (2). Persons bitten by ticks can also become infected with many other pathogens, such as bacteria (Anaplasma spp., Francisella spp., Coxiella burnetii, Bartonella spp., Rickettsiae spp., and Neoerhlichia mikurensis); parasites (Babesia spp., Theileria spp.); and arboviruses (tick-borne encephalitis virus, Crimean-Congo hemorr...


Monday 26 November 2012

Immunetics, Inc. Names John Yonkin as CEO

BOSTON, Nov. 26, 2012 (HSMN NewsFeed) -- Immunetics, Inc., an innovative developer of state-of-the-art assay technology for infectious disease diagnosis and blood screening, today announced that the company's Board of Directors has appointed John Yonkin ... Diagnostics, PersonnelImmunetics, BacTx, Lyme disease, Babesiosis, Chagas disease (Source: HSMN NewsFeed)


Friday 23 November 2012

Biodiversity and disease: a synthesis of ecological perspectives on Lyme disease transmission.

Authors: Wood CL, Lafferty KD Abstract Recent reviews have argued that disease control is among the ecosystem services yielded by biodiversity. Lyme disease (LD) is commonly cited as the best example of the 'diluting' effect of biodiversity on disease transmission, but many studies document the opposite relationship, showing that human LD risk can increase with forestation. Here, we unify these divergent perspectives and find strong evidence for a positive link between biodiversity and LD at broad spatial scales (urban to suburban to rural) and equivocal evidence for a negative link between biodiversity and LD at varying levels of biodiversity within forests. This finding suggests that, across zoonotic disease agents, the biodiversity-disease relationship is scale dependent and com...


Thursday 22 November 2012

Changes in Borrelia burgdorferi ELISA antibody over time in both antibiotic treated and untreated horses.

The objective of this study was to compare Borrelia ELISA antibody concentrations in naturally exposed horses both before and following antibiotic treatment for Lyme disease. A retrospective study was performed comparing oxytetracycline- or doxycyclinetreated (n = 68) and untreated (n = 183) horses from a single equine practice and their change in Borrelia ELISA values over a similar time period. Antibiotictreated horses had a decline in ELISA values in comparison to control horses (P ≤ 0.05) and untreated horses were twice as likely to have their ELISA values increase (OR = 0.5; 95% C.I. = 0.3-0.9) compared to treated horses. The magnitude of the decline in ELISA units following treatments was small compared to that previously reported in experimentally infected and treated ponies. Fiel...


Wednesday 21 November 2012

Abundance of Ixodes ricinus and prevalence of Borrelia burgdorferi s.l. in the nature reserve Siebengebirge, Germany, in comparison to three former studies from 1978 onwards

Ixodes ricinus abundances and Borrelia prevalences at three biotopes in the Siebengebirge, Germany, compared with data from previous studies, revealed increasing abundances since 1987. Prevalences did not increase simultaneously, but the number of multiple Borrelia infections in ticks rose. Image: Galio-Fagetum typicum biotope and Ixodes ricinus at the nature reserve Siebengebirge, Germany. (Source: Parasites and Vectors)

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Friday 16 November 2012

PodMed: A Medical News Roundup from Johns Hopkins (with audio)

(MedPage Today) -- This week's topics include steroid injections for sciatica, fungal injection following steroid injection, probiotics for Clostridium difficile infection, and recurrent versus relapsing Lyme disease. (Source: MedPage Today Pain Management)


Thursday 15 November 2012

Lyme Rash Reappearance Probably Signals New Infection, Study Says

Title: Lyme Rash Reappearance Probably Signals New Infection, Study SaysCategory: Health NewsCreated: 11/14/2012 6:36:00 PMLast Editorial Review: 11/15/2012 12:00:00 AM (Source: MedicineNet Hepatitis C General)


Thursday 15 November 2012

Second cases of Lyme rash are often reinfection

NEW YORK (Reuters Health) - When the bulls-eye-shaped rash of Lyme disease reappears many months after treatment, the source is almost certainly a new tick bite and not a resurgence of the original infection, according to a new analysis of 17 patients. (Source: Modern Medicine)


Thursday 15 November 2012

Recurring Lyme Disease Symptoms Caused by New Infection, Study Finds

Research comparing the genetic signatures of Lyme bacteria in people who had the disease more than once challenges the notion that it has a tendency to turn into a chronic illness. (Source: NYT Health)


Wednesday 14 November 2012

Lyme Disease Recurrences May Be Reinfections, Not RelapsesLyme Disease Recurrences May Be Reinfections, Not Relapses

Repeat episodes of Lyme disease (erythema migrans) in antibiotic-treated patients result from reinfection and not relapse. Medscape Medical News (Source: Medscape Today Headlines)

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Wednesday 14 November 2012

Second cases of Lyme rash are often reinfection

NEW YORK (Reuters Health) - When the bulls-eye-shaped rash of Lyme disease reappears many months after treatment, the source is almost certainly a new tick bite and not a resurgence of the original infection, according to a new analysis of 17 patients. (Source: Reuters: Health)


Wednesday 14 November 2012

New Infection, Not Relapse, Brings Back Symptoms of Lyme Disease, Study Finds

Research comparing the genetic signatures of Lyme bacteria in people who had the disease more than once challenges the notion that it has a tendency to turn into a chronic illness. (Source: NYT Health)


Wednesday 14 November 2012

Reinfection versus Relapse in Lyme Disease

New England Journal of Medicine, Volume 367, Issue 20, Page 1950-1951, November 2012. (Source: New England Journal of Medicine)


Wednesday 14 November 2012

Differentiation of Reinfection from Relapse in Recurrent Lyme Disease

New England Journal of Medicine, Volume 367, Issue 20, Page 1883-1890, November 2012. (Source: New England Journal of Medicine)


Wednesday 14 November 2012

Lyme Rash Reappearance Probably Signals New Infection, Study Says

It's even more likely when bull's-eye rash shows up on different part of body Source: HealthDay Related MedlinePlus Pages: Antibiotics, Lyme Disease (Source: MedlinePlus Health News)

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Wednesday 14 November 2012

Repeat Lyme Is Reinfection, Not Relapse (CME/CE)

(MedPage Today) -- All patients successfully treated for Lyme disease with antibiotics who then had another episode of erythema migrans had a reinfection rather than a relapse, a small study showed. (Source: MedPage Today Rheumatology)


Wednesday 14 November 2012

Newly Emerging Tick-Borne Afflictions Challenge Scientists To Improve Diagnosis And Surveillance

An emerging tick-borne disease that causes symptoms similar to malaria is expanding its range in areas of the northeast where it has become well-established, according to new research presented at the annual meeting of the American Society of Tropical Medicine and Hygiene (ASTMH). Researchers from the Yale School of Public Health reported that from 2000 to 2008, cases of babesiosis - which invades red blood cells and is carried by the same tick that causes Lyme disease - expanded from 30 to 85 towns in Connecticut... (Source: Health News from Medical News Today)


Wednesday 14 November 2012

Recurrent Lyme Disease Rash in Treated Patients Usually Due to Reinfection, Not Relapse

(Source: Physician's First Watch current issue)


Tuesday 13 November 2012

Disseminated Lyme Borreliosis preceded by hepatitis in an African American male.

Authors: Fathi R, Huang WW, Brown K Abstract Lyme disease is the most common tick-borne disease in the United States and has a multitude of systemic effects. Infrequently, however, Lyme disease is seen to cause liver dysfunction. Dermatologists should be aware that early, disseminated borreliosis can present with multiple erythema migrans plaques and hepatitis. PMID: 23122011 [PubMed - in process] (Source: Dermatol Online J)


Tuesday 13 November 2012

Tick-Borne Illnesses in U.S. Move Beyond Lyme Disease

Title: Tick-Borne Illnesses in U.S. Move Beyond Lyme DiseaseCategory: Health NewsCreated: 11/12/2012 12:36:00 PMLast Editorial Review: 11/13/2012 12:00:00 AM (Source: MedicineNet Hepatitis C General)

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Tuesday 13 November 2012

Murine Borrelia arthritis is highly dependent on ASC and caspase-1, but independent of NLRP3

An early murine Lyme arthritis model using intra-articular injection of live B.burgdorferi demonstrates that induction of Lyme arthritis is strongly dependent on IL-1β production, suggesting IL-1 may be a future therapeutic target. (Source: Arthritis Research and Therapy)


Monday 12 November 2012

Tick-Borne Illnesses in U.S. Move Beyond Lyme Disease

Malaria-like babesiosis has gained traction in Northeast, researchers say Source: HealthDay Related MedlinePlus Page: Tick Bites (Source: MedlinePlus Health News)


Monday 12 November 2012

Increased IFNα activity and differential antibody response in patients with a history of Lyme disease and persistent cognitive deficits

In this study, a longitudinal analysis of specific immune markers of interest was carried out in patients with a history of Lyme disease and persistent objective memory impairment, prior to and following treatment with either ceftriaxone or placebo. IFNα activity was measured by detection of serum-induced changes in specific target genes, using a functional cell-based assay and quantitative real-time PCR. Level and pattern of antibody reactivity to brain antigens and to Borrelia burgdorferi proteins were analyzed by ELISA and immunoblotting. Sera from the patient cohort induced significantly higher expression of IFIT1 and IFI44 target genes than those from healthy controls, indicating increased IFNα activity. Antibody reactivity to specific brain and borrelial proteins was significantly ...

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Sunday 11 November 2012

Spillover: Animal Infections and the Next Human Pandemic by David Quammen – review

Killer organisms and viruses that jump from animal to human are tracked down in this forensic studyLet's not beat around the bush. This is an extraordinary book. David Quammen has woven a story of incredible complexity; a detective story with a difference, with a host of murderers – all of them real. They are viruses, bacteria and single-celled organisms which infect other animals, but every now and then make the jump – spill over – to our own species. Each chapter follows the quest to track down a new villain. An international team of detectives works on the cases, and Quammen follows them as they uncover the traces which will lead them to the killers.After an opening chapter about a horrific virus which lays low horses and humans, the Ebola virus emerges through a dark tale, with p...


Thursday 8 November 2012

Borrelia burgdorferi infection and Lyme disease in children

Summary: Lyme disease is a multisystem disease that frequently affects children. It is caused by a group of related spirochetes, Borrelia burgdorferi sensu lato, that are transmitted by ticks belonging to species of the genus Ixodes. The clinical characteristics of Lyme disease in pediatrics resemble those observed in adults, although the symptoms may last for a shorter time and the outcome may be better. However, identifying Lyme disease in children can be significantly more difficult because some of its signs and symptoms can be similar to those of other common pediatric clinical manifestations. Finally, the diagnostic and therapeutic approach to childhood Lyme disease is frequently not codified, and guidelines specifically prepared for adults are used for children without having been va...


Thursday 8 November 2012

Lyme disease in the state of Tocantins, Brazil: report of the first cases.

Authors: Carranza-Tamayo CO, Costa JN, Bastos WM Abstract Lyme disease is an underdiagnosed zoonosis in Brazil. There are no cases registered in the state of Tocantins, the newest Brazilian state. The cases of three patients in contact with rural areas in three Tocantins' districts are herein described, and the Brazilian literature is reviewed. PMID: 23141972 [PubMed - as supplied by publisher] (Source: Braz J Infect Dis)


Wednesday 7 November 2012

Acetate supplementation reduces microglia activation and brain interleukin-1beta levels in a rat model of Lyme neuroborreliosis

Conclusions: These results suggest that microglial activation is an essential component to neuroborreliosis and that acetate supplementation may be an effective treatment to reduce injury phenotype and possibly injury progression in Lyme neuroborreliosis. (Source: Journal of Neuroinflammation)

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Wednesday 7 November 2012

Acetate supplementation reduces microglia activation and brain interleukin-1beta levels in a rat model of Lyme neuroborreliosis

Conclusions: These results suggest that microglial activation is an essential component to neuroborreliosis and that acetate supplementation may be an effective treatment to reduce injury phenotype and possibly injury progression in Lyme neuroborreliosis. (Source: Journal of Neuroinflammation)


Monday 5 November 2012

FDA warns Tennessee company that online product claims violate federal law

The U.S. Food and Drug Administration today issued a Warning Letter to The Avalon Effect Inc., a company based in Franklin, Tenn., for its marketing of a light therapy product that claims to cure or treat symptoms of fungal meningitis, methicillin-resistant Staphylococcus aureus (MRSA), concussions, Lyme disease, and other diseases. (Source: Food and Drug Administration)


Monday 5 November 2012

Seroprevalence of Lyme disease and genospecies of Borrelia burgdorferi sensu lato in patients diagnosed with borreliosis in the Province of Warmia-Masuria in north-eastern Poland.

Authors: Kubiak K, Dzika E, Równiak J, Dziedziech M, Dzisko J Abstract Between 2009-2010, a group of 259 patients suspected of contracting Lyme disease were examined in the Provincial Sanitary-Epidemiological Station in Olsztyn for the presence of IgM and IgG against specific Borrelia burgdorferi sensu lato (s.l.) genospecies antigens by immunoblot. A total of 27.4% and 29.0% of the blood serum samples showed positive and uncertain results for IgM and IgG antibodies. The majority of positive and uncertain results were found in patients aged 30-40 years (30%) for IgM, and people aged 50 and over (35.8%) for IgG. Significantly more positive results for IgG were found in males (40.2%) then females (19.7%). In both groups, similar proportions of positive results for IgM anti-Borrelia ...


Monday 5 November 2012

Seroprevalence of Leptospira spp. and Borrelia burgdorferi sensu lato in Italian horses.

Authors: Ebani VV, Bertelloni F, Pinzauti P, Cerri D Abstract The aim of the study was to determine the seroprevalence of Leptospira spp. and Borrelia burgdorferi sensu lato in healthy horses living in 7 provinces of central Italy. In the period 2007-2009, sera from 386 horses were tested by microagglutination test (MAT) to detect antibodies to Leptospira spp., employing the following serovars as antigens: Bratislava, Ballum, Canicola, Icterohaemorrhagiae, Grippotyphosa, Hardjo, Pomona, Tarassovi. 3 animals were positive for the serovars Icterohaemorrhagiae, 2 to Bratislava, and 1 to Pomona, for a total 1.5% seroprevalence. All sera were examined by immunofluorence antibody test (IFAT) to reveal anti-B. burgdorferi s.l. antibodies. 94 (24.3%) horses were positive with antibody titr...


Friday 2 November 2012

New Tick Disease In Switzerland

Until now, we knew that ticks primarily transmit two pathogens to humans in Switzerland: the bacterium Borrelia burgdorferi - which causes borreliosis - and the early-summer-meningoencephalitis virus, which can cause cerebral inflammation. Now, microbiologists from the University of Zurich confirm the existence of another tick disease in Switzerland - neoehrlichiosis. The pathogenic bacteria Candidatus Neoehrlichia mikurensis was first discovered in ticks and rodents in Europe and Asia in 1999... (Source: Health News from Medical News Today)


Thursday 1 November 2012

Reinfection Likely Spur of Repeat Lyme

When erythema migrans recurs a year or more after standard courses of antibiotic therapy for Lyme disease, it most likely represents a reinfection from another tick bite, not a relapse of the first infection, according to a report. (Source: Rheumatology News International)


Thursday 1 November 2012

A novel iron‐ and copper‐binding protein in the Lyme disease spirochaete

Summary Iron and copper are transition metals that can be toxic to cells due to their abilities to react with peroxide to generate hydroxyl radical. Ferritins and metallothioneins are known to sequester intracellular iron and copper respectively. The Lyme disease pathogen Borrelia burgdorferi does not require iron, but its genome encodes a ferritin‐like Dps (DNA‐binding protein from starved bacteria) molecule, which has been shown to be important for the spirochaete's persistence in the tick and subsequent transmission to a new host. Here, we show that the carboxyl‐terminal cysteine‐rich (CCR) domain of this protein functions as a copper‐binding metallothionein. This novel fusion between Dps and metallothionein is unique to and conserved in all Borrelia species. We term this mole...

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Wednesday 31 October 2012

Bartonella spp. Bacteremia and Rheumatic Symptoms in Patients from Lyme Disease-endemic Region.

Authors: Ben Beard C, Nelson CA, Mead PS, Petersen LR Abstract TO THE EDITOR: We believe the recent article by Maggi et al. (1) contains serious flaws in content and underlying message, including a poorly defined study population, lack of appropriate controls, improper use of the term bacteremia, and incongruent laboratory findings. Selection criteria were vague: the authors state only that participants were a "biased" collection of "patients selected by a rheumatologist," with no control population included for comparison. The diagnosis of Lyme disease and other previously diagnosed conditions was solely by self-report. Although blood samples were collected from every participant, the authors apparently neglected to perform standardized testing for Borrelia burgdorferi or other co...


Tuesday 30 October 2012

Lyme disease: aetiopathogenesis, factors for disease development and control

Abstract  Lyme disease is caused by infection with several genospecies from the Borrelia burgdorferi sensu lato (s.l.) complex, and is transmitted by ixodid ticks. Human disease is an infrequent sequel to infection, which suggests that multiple factors underlie disease development. Several innate immune defects modulating disease development are observed in both natural and experimental infections, and significant heterogeneity exists between B. burgdorferi s.l. spirochaetes. These factors create a panel of presentations from asymptomatic carriage to overt and variable disease. In this short review we summarise the host immune responses associated with Lyme disease in humans, domestic species and laboratory mouse strains, and discuss B. burgdorferi s.l. pathogenicity. We also...


Tuesday 30 October 2012

New Technique Enables Scientists To Step Up Hunt For Bacterial Genes Tied To Lyme Disease

Investigators at The University of Texas Health Science Center at Houston (UTHealth) have accelerated the search for the bacterial genes that make the Lyme disease bacterium so invasive and persistent. The discovery could advance the diagnosis and treatment of this disease, which affects an estimated 30,000 Americans each year. The researchers have developed a new technique that allowed them to test 15 times more bacterial genes than had been evaluated in the previous 30 years to ascertain their roles in infection... (Source: Health News from Medical News Today)

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Monday 29 October 2012

Management of paediatric Lyme disease in non-endemic and endemic areas: data from the Registry of the Italian Society for Pediatric Infectious Diseases

Abstract  The purpose of this investigation was to determine how specialists in paediatric infectious diseases (PIDs) manage children with suspected Lyme disease (LD) by comparing their approaches in Italian endemic and non-endemic areas. A cross-sectional survey of the PID specialists participating in the Italian Society for Pediatric Infectious Disease (SITIP) Registry of LD was carried out between 1 January and 30 April 2012. A total of 160 children (80 living in endemic areas and 80 living in non-endemic areas) were diagnosed as having LD between 1 January 2005 and 31 December 2011. The clinical manifestations were erythema migrans in 130 cases (81.3 %), arthritis in 24 (15.0 %) and neuroborreliosis in six (3.8 %). Significant differences from the recomme...


Monday 29 October 2012

[Should a lumbar puncture be performed in any child with acute peripheral facial palsy and clinical suspicion of Lyme borreliosis?]

Authors: Blin-Rochemaure N, Quinet B Abstract Lyme borreliosis should be considered in any child affected with acute peripheral facial palsy without obvious cause in endemic areas, especially if it happens from May to November, with a history of erythema migrans, tick bite, or possible exposure during the previous weeks. The clinical appearance of Lyme borreliosis differs between adults and children and according to the geographical origin of the infection: therefore it is difficult to interpret and follow the recommendations for the management and treatment of this disease. Neuroborreliosis is more frequent in Europe than in the United States, and meningitis associated to facial palsy occurs earlier and is more frequent among the European pediatric population, too. When peripheral...


Friday 26 October 2012

Scientists step up hunt for bacterial genes tied to Lyme disease

(University of Texas Health Science Center at Houston) Lyme disease is a bacterial illness that affects tens of thousands. It can lead to abnormalities in the nervous system, heart and joints. New research into the bacterium's genetic makeup could advance the diagnosis, treatment or prevention of the disease. A preclinical study by scientists at the University of Texas Health Science Center at Houston appears in the journal PLOS ONE. (Source: EurekAlert! - Medicine and Health)


Thursday 25 October 2012

Scientists step up hunt for bacterial genes tied to lyme disease

Lyme disease is a bacterial illness that affects tens of thousands. It can lead to abnormalities in the nervous system, heart and joints. New research into the bacterium’s genetic makeup could advance the diagnosis, treatment or prevention of the disease. (Source: ScienceDaily Headlines)


Thursday 25 October 2012

The musculoskeletal abnormalities of the Simulaun Iceman (“ÖTZI”): clues to chronic pain and possible treatments

Conclusions  These observations highlight several diagnostic features of musculoskeletal conditions in the Iceman with the possibility that tattoos may have been used for diagnosis or location of his painful states. The origins of his musculoskeletal conditions are unclear but there are indications that Lyme disease and CHD may have been factors. The associations or use of natural products may give insights into their applications at the time of the life of the Iceman. Content Type Journal ArticleCategory Research ArticlePages 1-10DOI 10.1007/s10787-012-0153-5Authors Walter F. Kean, Division of Rheumatology, McMaster University, 401-1 Young Street, Hamilton, ON L8N1T8, CanadaShannon Tocchio, Department of Radiology, University of Pittsburg, Pittsburg, USAMary Kean, ...

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Thursday 25 October 2012

The musculoskeletal abnormalities of the Similaun Iceman (“ÖTZI”): clues to chronic pain and possible treatments

Conclusions  These observations highlight several diagnostic features of musculoskeletal conditions in the Iceman with the possibility that tattoos may have been used for diagnosis or location of his painful states. The origins of his musculoskeletal conditions are unclear but there are indications that Lyme disease and CHD may have been factors. The associations or use of natural products may give insights into their applications at the time of the life of the Iceman. Content Type Journal ArticleCategory Research ArticlePages 1-10DOI 10.1007/s10787-012-0153-5Authors Walter F. Kean, Division of Rheumatology, McMaster University, 401-1 Young Street, Hamilton, ON L8N1T8, CanadaShannon Tocchio, Department of Radiology, University of Pittsburg, Pittsburg, USAMary Kean, ...


Wednesday 24 October 2012

Vascular binding of a pathogen under shear force through mechanistically distinct sequential interactions with host macromolecules

Summary Systemic dissemination of microbial pathogens permits microbes to spread from the initial site of infection to secondary target tissues and is responsible for most mortality due to bacterial infections. Dissemination is a critical stage of disease progression by the Lyme spirochaete, Borrelia burgdorferi. However, many mechanistic features of the process are not yet understood. A key step is adhesion of circulating microbes to vascular surfaces in the face of the shear forces present in flowing blood. Using real‐time microscopic imaging of the Lyme spirochaete in living mice we previously identified the first bacterial protein (B. burgdorferi BBK32) shown to mediate vascular adhesion in vivo. Vascular adhesion is also dependent on host fibronectin (Fn) and glycosaminoglycans (G...


Monday 22 October 2012

Are magazines at the dentist a health risk? Publications 'can spread germs and should be thrown out after a week'

An NHS infection control worker advised Monica Symes, a dentist in Lyme Regis, Dorset, to throw out or recycle magazines because they could spread germs. (Source: the Mail online | Health)


Wednesday 17 October 2012

Spirochetal ‘debris’ versus persistent infection in chronic Lyme disease: from semantics to science

Future Microbiology , November 2012, Vol. 7, No. 11, Pages 1243-1246. (Source: Future Microbiology)


Friday 12 October 2012

Single-tier testing with the C6 peptide ELISA kit compared with two-tier testing for Lyme disease

In conclusion, using a reference standard of 2-tier testing, the C6 ELISA as a single-step serodiagnostic test provided increased sensitivity in early Lyme disease with comparable sensitivity in later manifestations of Lyme disease. The C6 ELISA had slightly decreased specificity. Future studies should evaluate the performance of the C6 ELISA compared with 2-tier testing in routine clinical practice. (Source: Diagnostic Microbiology and Infectious Disease)

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Monday 8 October 2012

Antibiotic retreatment of Lyme disease in patients with persistent symptoms: A biostatistical review of randomized, placebo-controlled, clinical trials

Discussion: This biostatistical review reveals that retreatment can be beneficial. Primary outcomes originally reported as statistically insignificant were likely underpowered. The positive treatment effects of ceftriaxone are encouraging and consistent with continued infection, a hypothesis deserving additional study. Additional studies of persistent infection and antibiotic treatment are warranted. (Source: Contemporary Clinical Trials)


Monday 8 October 2012

Cerebrospinal fluid Alzheimer's biomarker profiles in CNS infections

Abstract  The cerebrospinal fluid (CSF) biomarker profile in Alzheimer's disease (AD) is characterized by decreased beta amyloid (Aβ1-42), increased total and hyperphosphorylated tau (t-tau and p-tau, respectively), which is a useful diagnostic tool and gives insight in the pathogenesis of AD. It is of importance to study how these biomarkers react in other CNS diseases; therefore, we decided to analyse amyloid and tau biomarkers in different CNS infections. We also included analysis of soluble amyloid precursor proteins (sAPPα and -β). CSF Aβ1-42, sAPPα and -β, t-tau and p-tau were analysed in bacterial meningitis (n = 12), Lyme neuroborreliosis (n = 13), herpes simplex virus type 1 (HSV-1) encephalitis (n = 10), HIV-associated dementia (HA...


Monday 8 October 2012

A novel human autoantigen, endothelial cell growth factor, is a target of T and B cell responses in patients with Lyme disease

Conclusion.T and B cell responses to ECGF occur in a subset of patients with Lyme disease, particularly in those with antibiotic‐refractory arthritis, providing the first direct evidence for autoimmune T and B cell responses in this illness. © 2012 American College of Rheumatology. (Source: Arthritis and Rheumatism)


Thursday 4 October 2012

Lyme disease: How a little tick can make you ill

Lyme disease — Comprehensive overview covers symptoms, treatment, complications of this tick-borne illness. (Source: MayoClinic.com Full Feed)


Monday 1 October 2012

Wild Birds and Urban Ecology of Ticks and Tick-borne Pathogens, Chicago, Illinois, USA, 2005-2010.

Authors: Hamer SA, Goldberg TL, Kitron UD, Brawn JD, Anderson TK, Loss SR, Walker ED, Hamer GL Abstract Bird-facilitated introduction of ticks and associated pathogens is postulated to promote invasion of tick-borne zoonotic diseases into urban areas. Results of a longitudinal study conducted in suburban Chicago, Illinois, USA, during 2005-2010 show that 1.6% of 6,180 wild birds captured in mist nets harbored ticks. Tick species in order of abundance were Haemaphysalis leporispalustris, Ixodes dentatus, and I. scapularis, but 2 neotropical tick species of the genus Amblyomma were sampled during the spring migration. I. scapularis ticks were absent at the beginning of the study but constituted the majority of ticks by study end and were found predominantly on birds captured in areas...

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Monday 1 October 2012

A Novel Iron‐ and Copper‐Binding Protein in the Lyme Disease Spirochete

Summary Iron and copper are transition metals that can be toxic to cells due to their abilities to react with peroxide to generate hydroxyl radical. Ferritins and metallothioneins are known to sequester intracellular iron and copper, respectively. The Lyme disease pathogen Borrelia burgdorferi does not require iron, but its genome encodes a ferritin‐like Dps (DNA‐binding protein from starved bacteria) molecule, which has been shown to be important for the spirochete's persistence in the tick and subsequent transmission to a new host. Here, we show that the carboxyl‐terminal cysteine‐rich (CCR) domain of this protein functions as a copper‐binding metallothionein. This novel fusion between Dps and metallothionein is unique to and conserved in all Borrelia species. We term this mole...


Thursday 27 September 2012

The unique paradigm of spirochete motility and chemotaxis.

Authors: Charon NW, Cockburn A, Li C, Liu J, Miller KA, Miller MR, Motaleb MA, Wolgemuth CW Abstract Spirochete motility is enigmatic: It differs from the motility of most other bacteria in that the entire bacterium is involved in translocation in the absence of external appendages. Using the Lyme disease spirochete Borrelia burgdorferi (Bb) as a model system, we explore the current research on spirochete motility and chemotaxis. Bb has periplasmic flagella (PFs) subterminally attached to each end of the protoplasmic cell cylinder, and surrounding the cell is an outer membrane. These internal helix-shaped PFs allow the spirochete to swim by generating backward-moving waves by rotation. Exciting advances using cryoelectron tomography are presented with respect to in situ analysis of...


Thursday 27 September 2012

Controlling the spread of diseases among humans, other animals and the environment

(National Science Foundation) West Nile virus, Lyme disease and hantavirus are all infectious diseases spreading in animals and in people. Is human interaction with the environment somehow responsible for the increase in incidence of these diseases? (Source: EurekAlert! - Medicine and Health)


Wednesday 26 September 2012

Neuropsychiatric presentation of Lyme disease in Australia.

Authors: Maud C, Berk M PMID: 23015751 [PubMed - as supplied by publisher] (Source: The Australian and New Zealand Journal of Psychiatry)


Tuesday 25 September 2012

Stop. Look up, look down. There are natural wonders on your doorstep | Ian Vince

You don't have to pedalo up the Congo for spectacle. As a new category of cloud is being called for, here are five more delightsIt seems to be the prevailing belief that there is little left of the world to explore; Antarctica, the north pole, the Himalayan peaks, various inpenetrable rainforests and raging rivers, all have been "discovered" or, at least, provided a picturesque backdrop to the achievements and glory of a rakish adventurer or two. Perilous challenges of exploration or – depending on your opinion – desperate howls for attention, now have to try that bit harder and skiing down K2 or swimming the 2,000 miles of the Volga have become the next adventures. After that we've only got an attempt to pedalo up the Congo, hang-glide around a hurricane or cartwheel across the Kalaha...

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Monday 24 September 2012

HHS Federal Research Update on Lyme Disease Diagnostics Activities, September 24, 2012

The Centers for Disease Control and Prevention, National Institutes of Health, and Food and Drug Administration are committed to helping advance research and application toward new and improved laboratory diagnostics for Lyme disease. (Source: Food and Drug Adminstration (FDA): CDRHNew)


Thursday 20 September 2012

Risk of tick-borne diseases in various categories of employment among forestry workers in eastern Poland.

The objective of this study was an evaluation of the exposure of forestry workers employed at individual workplaces to infection with tick-borne pathogens (especially Borrelia burgdorferi spirochetes), based on epidemiological investigation and serologic tests. Epidemiological studies covered 111 forestry employees from eastern Poland employed in 4 randomly-selected forest inspectorates which replied to questions in the area of epidemiology and prophylaxis of diseases transmitted by ticks. Eighty-two forestry workers employed in one forest inspectorate were examined for the presence of specific anti-Borrelia burgdorferi antibodies. The correlation between individual items of the questionnaire was assessed by Spearman's test. Results of serological tests were assessed by Mann-Whitney test. ...


Thursday 20 September 2012

Risk of Lyme disease at various sites and workplaces of forestry workers in eastern Poland.

In conclusion, forestry workers employed at such stands of work as timber acquisition, growing of forest, forest cultivation and forest protection are nearly at the same risk of Borrelia burgdorferi infection. PMID: 23020040 [PubMed - in process] (Source: Annals of Agricultural and Environmental Medicine : AAEM)


Thursday 20 September 2012

Molecular screening for [i]Bartonella henselae [/i]and [i]Borrelia burgdorferi[/i] sensu lato co-existence within [i]Ixodes ricinus[/i] populations in central and eastern parts of Poland.

Authors: Sytykiewicz H, Karbowiak G, Werszko J, Czerniewicz P, Sprawka I, Mitrus J Abstract The presented study aimed at establishing the prevalence and co-infection rates of Bartonella henselae and Borrelia burgdorferi sensu lato in Ixodes ricinus ticks collected from the central and eastern parts of Poland. The common tick individuals were gathered in the years 2008-2009. Questing ticks were sampled by dragging a white woollen flag over lower vegetation at 17 localities within diverse types of habitats: urban recreational green areas (city parks and squares), suburban forests and rural woodlands throughout the investigated regions of Poland. Detection of B. henselae in tested tick specimens was based on PCR amplification of the citrate synthase (gltA) gene, while screening for th...


Wednesday 12 September 2012

Lyme Disease: The Culprit or Just Taking the Blame?Lyme Disease: The Culprit or Just Taking the Blame?

Paul G. Auwaerter, MD, describes new research that sheds some additional light on Lyme disease. Medscape Infectious Diseases (Source: Medscape Today Headlines)

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Wednesday 12 September 2012

Misdiagnosis of late Lyme arthritis by inappropriate use of synovial fluid Borrelia burgdorferi immunoblot testing.

ConclusionDiagnosis of Lyme arthritis should not be based on synovial fluid B. burgdorferi immunoblot testing. This unvalidated test does not appear useful for the diagnosis of Lyme disease and this study reinforces the long-standing recommendation to use B. burgdorferi immunoblot testing only on serum samples and not other body fluids. Erroneous interpretations of "positive" synovial fluid immunoblots may lead to inappropriate antibiotic courses and delays in diagnosis of other joint disease. PMID: 22971779 [PubMed - as supplied by publisher] (Source: Clinical and Vaccine Immunology)


Wednesday 12 September 2012

Highlights on molecular identification of closely related species.

Authors: Almeida LA, Araujo R Abstract The term "complex" emerged in the literature at the beginning of the genomic era associated to taxonomy and grouping organisms that belong to different species but exhibited similar patterns according to their morphological, physiological and/or other phenotypic features. DNA-DNA hybridization values ⩾70% and high identity on 16S rRNA gene sequences were recommended for species delineation. Electrophoretic methods showed in some cases to be useful for species identification and population structure but the reproducibility was questionable. Later, the implementation of polyphasic approaches involving phenotypic and molecular methods brought new insights into the analysis of population structure and phylogeny of several "species complexes", al...


Tuesday 11 September 2012

Precautions For Tick-Borne Disease Extend "Beyond Lyme"

This year's mild winter and early spring were a bonanza for tick populations in the eastern United States. Reports of tick-borne disease rose fast. While Lyme disease is the most common tick-borne disease in the Northeast and Upper Midwest, new research results emphasize that it is not the greatest cause for concern in most Southeastern states. The findings were published recently in a paper in the journal Zoonoses and Public Health... (Source: Health News from Medical News Today)


Monday 10 September 2012

Video: Climate may be behind increase in bug-borne illness

West Nile virus has killed 87 Americans so far this year. Dr. William Schaffner, past President of the National Foundation for Infectious Diseases, tells Gayle King and Charlie Rose why the weather may be causing an uptick in cases of West Nile, Lyme Disease and even the bubonic plague. (Source: Health News: CBSNews.com)


Friday 7 September 2012

Lyme Disease is Not the Only Tick-Borne Disease to Watch Out For

Precautions for Tick-Borne Disease Extend Beyond Lyme - Save the tick that bites you: it may not be the one you think. This year's mild winter and early spring were a bonanza for tick populations in the eastern United States. Reports of tick-borne disease rose fast. (Source: Disabled World)

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Friday 7 September 2012

Precautions for tick-borne disease extend 'beyond Lyme'

This year's mild winter and early spring were a bonanza for tick populations in the eastern United States. Reports of tick-borne disease rose fast. While Lyme disease is the most common tick-borne disease in the Northeast and Upper Midwest, new research results emphasize that it is not the greatest cause for concern in most Southeastern states. (Source: ScienceDaily Headlines)


Friday 7 September 2012

Acquired hepatocerebral degeneration revealed by neurogenic hyperventilation syndrome and myelitis

A 46-year-old woman with a history of kidney transplant for IgA nephropathy (on tacrolimus and mycophenolate mofetil), type II diabetes and non-alcoholic steatohepatitis was admitted for gait instability. Neurological examination revealed lower limb sensory ataxia and brisk patellar reflexes. Brain/spinal MRI results were normal. Blood tests disclosed macrocytosis (but no vitamin deficiencies) and mild hepatic cytolysis. Lumbar puncture showed the absence of cells, normal protein, hypoglycorrhachia (glycorrhachia: 0.62 g/l; glycaemia: 1.65 g/l) and no oligoclonal bands. Cerebrospinal fluid cultures were negative. Assays for neurotropic viruses, paraneoplastic antibodies, HIV, syphilis, hepatitis, Tropheryma whipplei, Lyme borreliosis, Schistosoma and auto-immune markers were nega...


Wednesday 5 September 2012

New Virus Tied to Ticks Poses Puzzle for Doctors

Scientists at the Centers for Disease Control and Prevention think [two men in Missouri] were infected by lone star ticks, meaning that there may be a frightening new addition to the list of tick-borne dangers that includes Lyme disease, babesiosis and Rocky Mountain spotted fever. (Source: RWJF News Digest - Public Health)


Tuesday 4 September 2012

Genetics of Borrelia burgdorferi.

Authors: Brisson D, Drecktrah D, Eggers CH, Samuels DS Abstract The spirochetes in the Borrelia burgdorferi sensu lato genospecies group cycle in nature between a tick vector and a vertebrate host. The current assemblage of B. burgdorferi sensu lato, of which three species cause Lyme disease in humans, originated from a rapid species radiation that occurred near the origin of the clade. These bacteria have a unique genome that is highly segmented and predominantly composed of linear replicons. One of the circular plasmids is a prophage that exists as several isoforms in each cell and can be transduced to other cells, likely contributing to an otherwise relatively anemic level of horizontal gene transfer, which nevertheless appears to be adequate to permit strong natural selection a...

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Monday 3 September 2012

New Tick-Borne Heartland Virus Has Scientists Puzzled

The so-called Heartland virus, never seen before, is the apparent cause of severe illness in two Missouri men who were bitten by ticks. (Source: NYT Health)


Monday 3 September 2012

Guidance For Retreatment Of Lyme Disease May Be Flawed

A new statistical review calls into question studies that have been taken as proof that antibiotic retreatment for chronic Lyme disease is futile. That misunderstanding has led to medical guidance that discourages retreatment and insurance coverage for it. Instead, the authors of the review suggest, the proper reading of the studies and their data is that they prove nothing. Most doctors treat Lyme disease with antibiotics for two to four weeks after diagnosis, but if symptoms persist after that, medical guidelines recommend against antibiotic retreatment... (Source: Health News from Medical News Today)


Monday 3 September 2012

Red nodule on the breast

We report this case to highlight the importance of an investigation of Lyme borreliosis when a patient living in the countryside presents with a red nodule of the nipple and areola. (Source: Indian Journal of Dermatology)


Monday 3 September 2012

Guidelines Advising Against Retreating Persistent Lyme Disease Questioned

(Source: Physician's First Watch current issue)


Thursday 30 August 2012

Perinuclear antineutrophil cytoplasmic autoantibodies in dogs infected with various vector-borne pathogens and in dogs with immune-mediated hemolytic anemia.

Conclusions and Clinical Relevance-pANCA were detected in a high percentage of dogs with IMHA and vector-borne infectious diseases. Therefore, pANCA may be a relatively nonspecific marker for dogs with inflammatory bowel disease, although they could represent a biomarker for immune-mediated diseases and infections. PMID: 22924722 [PubMed - in process] (Source: American Journal of Veterinary Research)

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Thursday 30 August 2012

Lyme retreatment guidance may be flawed

A new statistical review calls into question studies that have been taken as proof that antibiotic retreatment for chronic Lyme disease is futile. That misunderstanding has led to medical guidance that discourages retreatment and insurance coverage for it. Instead, the authors of the review suggest, the proper reading of the studies and their data is that they prove nothing. (Source: ScienceDaily Headlines)


Thursday 30 August 2012

Lyme endocarditis

Abstract Lyme borreliosis is a common tick‐borne disease with a wide variety of clinical manifestations. Cardiac involvement has been reported during both the acute phase (atrioventricular block, pericarditis) and the chronic stage (dilated cardiomyopathy), but is rare (less than 5%). Here we describe the first case of Borrelia afzelii Lyme endocarditis, in a 61‐year‐old man living in an endemic area of France. The diagnosis was confirmed by detection of B. afzelii DNA in the mitral valve by specific real‐time PCR. He was treated empirically with amoxicillin for 6 weeks and remains well 12 months later. © 2012 The Authors Clinical Microbiology and Infection © 2012 European Society of Clinical Microbiology and Infectious Diseases (Source: Clinical Microbiology and Infection)


Wednesday 29 August 2012

[Cardiovascular manifestations of Lyme disease].

Authors: Siński M, Lewandowski J, Abramczyk P, Siński E PMID: 22718387 [PubMed - in process] (Source: Polish Heart Journal)


Tuesday 28 August 2012

Insect bite in the park left me in agony for SIX years

Rebecca Lane had Lyme disease, a bacterial infection spread to humans by ticks — tiny spider-like insects found in woodland. (Source: the Mail online | Health)

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Friday 24 August 2012

U.S. Extends Recreational Trail Protection Program Funding

Dear EarthTalk : What exactly is the federal government’s Recreational Trails Program, and is it true that it’s on the chopping block? -- Randy Caldwell, Lyme, N.H. [More] (Source: Scientific American - Official RSS Feed)


Tuesday 21 August 2012

[Comment] Lack of knowledge can anger patients with chronic diseases

As seen in the correspondence related to Lyme disease, people with diseases of unknown cause want explanations at all costs. was introduced that was far from specific and gave false-positive results in 70% of cases, including patients with multiple sclerosis, schizophrenia, chronic arthritis, and myocardial infarction. The advent of immunofluorescence substantially decreased the number of false-positives, but throughout the 1990s I still saw patients with multiple sclerosis claiming to have a rickettsiosis and wanting to be treated with doxycycline. (Source: The Lancet Infectious Diseases)


Saturday 18 August 2012

First report of Borrelia burgdorferi sensu lato in two threatened carnivores: the Marbled polecat, Vormela peregusna and the European mink,

Conclusions: This is the first report of the Lyme disease spirochetes in the two mentioned hosts. (Source: BioMed Central)


Tuesday 14 August 2012

Associations of HLA DR and DQ molecules with Lyme borreliosis in Latvian patients

Background: Many autoimmune diseases are associated with variants of HLA genes such as those encoding the MHC complex. This correlation is not absolute, but may help in understanding of the molecular mechanism of disease. The purpose of this study was to determine HLA-DR,-DQ alleles in Latvian patients with Lyme borreliosis and control (healthy) persons. Case patients and control subjects were similar in age, gender and ethnic heritage and differed only as regards the presence of Borrelia burgdorferi infection. The study included 20 patients with clinical stage - erythema migrans and 25 control (healthy) persons. HLA genotyping was performed by PCR with sequence-specific primers. Results: The results show difference in HLA-DRB1 alleles distribution between patients and control subjects. Th...


Monday 13 August 2012

Prevalence and Genetic Characterization of Powassan Virus Strains Infecting Ixodes scapularis in Connecticut.

Authors: Anderson JF, Armstrong PM Abstract A total of 30 Powassan virus (POWV) isolates from Ixodes scapularis collected from Bridgeport and North Branford, CT in 2008, 2010, 2011, and 2012 and one earlier isolate from Ixodes cookei collected in Old Lyme, CT 1978 were characterized by phylogenetic analysis of their envelope gene sequences. Powassan virus sequences segregated into two major groups termed the deer tick virus (DTV) and Powassan (POW) lineages. The lineage from I. cookei was POW. The remaining viruses from I. scapularis grouped with the DTV lineage. Powassan viruses from Bridgeport were nearly identical and clustered with a virus strain from a human in New York. Viruses from North Branford were homogeneous and grouped with viruses from Massachusetts, northwestern ...

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Friday 10 August 2012

Species, developmental stage and infection with microbial pathogens of engorged ticks removed from dogs and questing ticks

Research into tick‐borne diseases implies vector sampling and the detection and identification of microbial pathogens. Ticks were collected simultaneously from dogs that had been exposed to tick bites and by flagging the ground in the area in which the dogs had been exposed. In total, 200 ticks were sampled, of which 104 came from dogs and 96 were collected by flagging. These ticks were subsequently examined for DNA of Borrelia burgdorferi sensu lato, Anaplasma phagocytophilum, Rickettsia spp. and Babesia canis. A mixed sample of adult ticks and nymphs of Ixodes ricinus (Ixodida: Ixodidae) and Haemaphysalis concinna (Ixodida: Ixodidae) was obtained by flagging. Female I. ricinus and adult Dermacentor reticulatus (Ixodida: Ixodidae) ticks dominated the engorged ticks removed from dogs. Ri...


Friday 10 August 2012

Well: Think Like a Doctor: A Peculiar Heartbeat Solved!

Readers solve the mystery of a 31-year-old woman with thyroid disease who drives herself to the emergency room because of palpitations and a very slow heartbeat. (Source: NYT Health)


Friday 10 August 2012

Contact with horses is a risk factor for tick-borne lymphadenopathy (TIBOLA): a case control study.

We describe here the seasonal, age and gender characteristics as well as the association with horse contact as risk factors for acquiring TIBOLA in comparison with another, more frequent tick-borne disease, Lyme borreliosis.We analysed a dataset of 855 patients diagnosed with either Lyme (n = 805) or TIBOLA (n = 50) disease using Fisher's exact tests and generalized linear models. Then we performed a matched case-control study in which all TIBOLA patients were paired with one Lyme patient matching in age and gender. We identified the species of ticks collected from the TIBOLA patients (n = 16).We found that horse contact was significantly more frequent among TIBOLA (34/50; 68 %) than among Lyme patients (110/805; 13.7 %) (OR = 13.35, p < 0.001). The younger age and...

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Wednesday 8 August 2012

Cure unwanted? Exploring the chronic Lyme disease controversy and why conflicts of interest in practice guidelines may be guiding us down the wrong path.

Authors: Ferguson J PMID: 22497097 [PubMed - indexed for MEDLINE] (Source: American Journal of Law and Medicine)


Tuesday 7 August 2012

Lyme disease.

Authors: Hu LT PMID: 22868858 [PubMed - in process] (Source: Annals of Internal Medicine)


Tuesday 7 August 2012

[Cardiovascular manifestations of Lyme disease.]

Authors: Siński M, Lewandowski J, Abramczyk P, Siński E PMID: 22718387 [PubMed - as supplied by publisher] (Source: Kardiologia Polska)


Monday 6 August 2012

Insect spread illnesses on the rise: how to protect your family

By  Carolyn Moriarty If you’ve been watching the news recently, you’re probably aware that mosquitos carrying eastern equine encephalitis (EEE) have been found in various areas across the country, including Massachusetts. EEE—and its less-dangerous counterpart, West Nile Virus—are two diseases that are spread to people by the bites of infected mosquitos. EEE is considered to be one of the most serious mosquito-borne illnesses in the United States. Inflammation of the brain, or encephalitis, is a frequent and life-threatening complication of EEE that may also lead to permanent neurological damage or coma. West Nile Virus is a much milder infection characterized by flu-like symptoms that generally go away on their own. There are things that area and state governments are doing to r...


Monday 6 August 2012

Infectious scleritis

Abstract Scleritis can occur as a result of an immunological response in systemic infectious diseases such as tuberculosis, leprosy, syphilis and lyme disease. These diseases are becoming more common and, as under‐treatment in many countries leads to incomplete elimination of the underlying infection, scleritis is becoming more common. Scleritis can also result from an immunological reponse to a systemic infection by bacteria, viruses , parasites or fungi. More rarely the sclera can be infected directly through the introduction of the organism into the sclera by trauma or from the spread of infection from adjacent sources. This is much more likely to happen if the tissue has been previously irradiated or surgically treated particularly after pterygium surgery. Infectious scleritis is les...

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Monday 6 August 2012

Lyme borreiosis with ocular manifestations during childhood period

Conclusion For any unexplained ocular symptom, even for children, LB should be taken into account especially in endemic areas. Such patients should undergo serological testing. If the clinical presentation is suggestive of LB, a course of oral antibiotics should be used. All in all, permanent defects are extremely rare during childhood period, even following long‐term manifestation at an early age. (Source: Acta Ophthalmologica)


Sunday 5 August 2012

[Signs and significance of a tick-bite: psychiatric disorders associated with Lyme disease].

CONCLUSION: Further investigations into borrelia-infection are indicated in case of atypical psychiatric disorders and/or an atypical response to treatment and when the anamnesis and/or physical examination are suggestive of Lyme disease. PMID: 22422416 [PubMed - indexed for MEDLINE] (Source: Tijdschrift voor Psychiatrie)


Thursday 2 August 2012

Clinical Roundup: Selected Treatment Options for Lyme Disease

Alternative and Complementary Therapies Aug 2012, Vol. 18, No. 4: 220-225. (Source: Alternative and Complementary Therapies)


Wednesday 1 August 2012

Long-term Clinical Outcome After Lyme Neuroborreliosis in Childhood

Persistent facial nerve palsy is a well-described neurologic deficit after Lyme neuroborreliosis and occurs in 13% to 20% of children. Other neurologic deficits are less closely described. Nonspecific subjective symptoms are reported as often among patients as controls in previous short-term follow-up studies. Persistent neurologic deficits, other than facial nerve palsy, were found in 14% of patients, causing impaired fine motor skills, poor balance, or persistent pain. Nonspecific subjective symptoms were reported as often among patients as controls in this long-term follow-up study and should not be considered as sequelae after Lyme neuroborreliosis. (Read the full article) (Source: PEDIATRICS)


Wednesday 1 August 2012

Probable late lyme disease: a variant manifestation of untreated Borrelia burgdorferi infection

Conclusions: We suggest that patients with probable late Lyme disease more closely resemble those with confirmed late Lyme disease rather than those with post-Lyme syndrome or another unexplained illness. Further studies are warranted to delineate later manifestations of Lyme disease and to quantify treatment benefit in this population. (Source: BMC Infectious Diseases)


Wednesday 1 August 2012

The DBA/1 Strain is a Novel Mouse Model for Experimental Borrelia burgdorferi Infection.

Conclusion: The DBA/1 murine strain is a suitable model for the study of Lyme arthritis and experimental B. burgdorferi infection, allowing direct comparison between Lyme arthritis and Collagen Induced Arthritis. The specificity of the humoral immune response differs between the two strains, further study of which may reveal important findings about how individual strains respond to B. burgdorferi infection. PMID: 22855391 [PubMed - as supplied by publisher] (Source: Clinical and Vaccine Immunology)


Wednesday 1 August 2012

Primary embryonic cells of Rhipicephalus microplus and Amblyomma cajennense ticks as a substrate for the development of Borrelia burgdorferi (strain G39/40).

We examined in vitro the characteristics of embryonic cells of Rhipicephalus microplus and Amblyomma cajennense in cell culture and investigated the suitability of embryonic cells as a substrate for cultivation of B. burgdorferi. Subcultures were prepared from primary cultures of embrionary cells of R. microplus and A. cajennense maintained in Leibovitz's (L-15) complete medium at 28 ºC and 31 ºC, respectively. When a monolayer had formed, the L-15 was replaced with Barbour-Stoener-Kelly medium for experiments to infect cell cultures with B. burgdorferi. After 72 hours of cultivation, the spirochetes were counted using an inverted phase contrast microscope and dark-field illumination (400×). Survival, multiplication and the adherence of B. burgdorferi for embryonic cells of R. microplus...


Tuesday 31 July 2012

Top 10 Dorset seafood restaurants

Dorset deserves a gold medal for its fish and seafood restaurants. Nick Fisher, co-author of The River Cottage Fish Book, chooses 10 of the best family-friendly places, many overlooking the water from where their catch originatedCrab House Café, Wyke RegisI've known the Crab House since it first opened, serving fresh shucked oysters picked from its own oyster beds just outside the restaurant's front door. Oysters – in fact seafood of all sorts – is a passion of Nigel Bloxham the owner and chef, and the cafe is perfectly situated to buy fish fresh from the Portland and Weymouth day boats. On a sunny day there is almost Caribbean/Floridian feel to The Crab House. Portland harbour is home of some stunning wild shell fish too, and the special, of razor clams with chorizo and young sweet b...


Tuesday 31 July 2012

Usefulness of antibody index assessment in cerebrospinal fluid from patients negative for total-IgG oligoclonal bands

Conclusion: Our findings indicate that AI testing should not generally be omitted in OCB-negative patients and provides a rationale for systematic and prospective studies on the comparative sensitivity and specificity of AI and total-IgG OCB testing in infectious and other diseases of the CNS. (Source: BioMed Central)

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Tuesday 31 July 2012

Lyme Disease - Test Your Knowledge About Lyme Disease

How much do you know about Lyme disease?: arthritis screening quiz osteoporosis screening lyme disease juvenile arthritis test your knowledge (Source: About.com Eating Disorders)


Monday 30 July 2012

Personal Health: Babesiosis May One Day Rival Lyme Disease

Babesiosis, which causes flulike symptoms and can be fatal, could eventually rival Lyme disease as the most common tick-borne ailment in the United States. (Source: NYT)


Monday 30 July 2012

Well: Babesiosis May One Day Rival Lyme Disease

Babesiosis, which causes flulike symptoms and can be fatal, could eventually rival Lyme disease as the most common tick-borne ailment in the United States. (Source: NYT Health)

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Monday 30 July 2012

Comparative molecular analyses of Borrelia burgdorferi sensu stricto strains B31 and N40D10/E9 and determination of their pathogenicity

Conclusion: Based upon the studies here, it can be predicted that N40D10/E9 disseminated infection atlower doses may be enhanced by its lower binding to epithelial cells at the site of inoculationdue to the absence of BBK32. We suggest that complete molecular analyses of virulencefactors followed by their evaluation using the mouse infection model should form the basis ofdetermining infectivity and pathogenicity of different strains rather than simple phylogeneticgroup analyses. This study further emphasizes a need to investigate multiple invasive strainsof B. burgdorferi to fully appreciate the pathogenic mechanisms that contribute to Lymedisease manifestations. (Source: BMC Microbiology - Latest articles)


Tuesday 24 July 2012

Lyme Disease Quiz: Test Your Medical IQ

Title: Lyme Disease Quiz: Test Your Medical IQCategory: MedicineNet QuizCreated: 6/15/2010 12:55:00 PMLast Editorial Review: 7/24/2012 6:39:59 PM (Source: MedicineNet Arthritis General)


Friday 20 July 2012

Health Tip: Check Yourself for Ticks

Use a mirror to check hard-to-see places Source: HealthDay Related MedlinePlus Pages: Lyme Disease, Tick Bites (Source: MedlinePlus Health News)


Thursday 19 July 2012

Opinionator | Townies: I'll Cover You

When government and insurance fell short, a community stepped in. (Source: NYT Health)


Wednesday 18 July 2012

The β3‐integrin ligand of Borrelia burgdorferi is critical for infection of mice but not ticks

This study is the first to define a B. burgdorferi adhesin as essential for mammalian, but not tick infection. (Source: Molecular Microbiology)

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Wednesday 18 July 2012

Using administrative medical claims data to supplement state disease registry systems for reporting zoonotic infections.

CONCLUSIONS: There are limitations with administrative claims data, but health plans may help bridge data gaps and support the federal administration's vision of combining public and private data into one source. PMID: 22811492 [PubMed - as supplied by publisher] (Source: Journal of the American Medical Informatics Association)


Sunday 15 July 2012

News Analysis: Destroying Nature Unleashes Infectious Diseases

A developing model of infectious disease shows that most epidemics — AIDS, Ebola, West Nile, SARS, Lyme disease — are a result of things people do to nature. (Source: NYT Health)


Friday 13 July 2012

CDC warns of tick-borne disease babesiosis

ATLANTA, July 13 (UPI) -- The tick that spreads Lyme disease also spreads babesiosis, a malaria-like parasitic disease reported in 1,100 cases in 2011, U.S. health officials say. (Source: Health News - UPI.com)


Wednesday 11 July 2012

Facile Synthesis of a Library of Lyme Disease Glycolipid Antigens

Organic LettersDOI: 10.1021/ol301697c (Source: Organic Letters)

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Wednesday 11 July 2012

Two CheW coupling proteins are essential in a chemosensory pathway of Borrelia burgdorferi

SummaryIn the model organism Escherichia coli, the coupling protein CheW, which bridges the chemoreceptors and histidine kinase CheA, is essential for chemotaxis. Unlike the situation in E. coli, Borrelia burgdorferi, the causative agent of Lyme disease, has three cheW homologues (cheW1, cheW2 and cheW3). Here, a comprehensive approach is utilized to investigate the roles of the three cheWs in chemotaxis of B. burgdorferi. First, genetic studies indicated that both the cheW1 and cheW3 genes are essential for chemotaxis, as the mutants had altered swimming behaviours and were non‐chemotactic. Second, immunofluorescence and cryo‐electron tomography studies suggested that both CheW1 and CheW3 are involved in the assembly of chemoreceptor arrays at the cell poles. In contrast to cheW1 ...


Tuesday 10 July 2012

Rational diagnostic strategies for Lyme borreliosis in children and adolescents: recommendations by the Committee for Infectious Diseases and Vaccinations of the German Academy for Pediatrics and Adolescent Health

Abstract  The varying clinical manifestations of Lyme borreliosis, transmitted by Ixodes ricinus and caused by Borrelia burgdorferi, frequently pose diagnostic problems. Diagnostic strategies vary between early and late disease manifestations and usually include serological methods. Erythema migrans is pathognomonic and does not require any further laboratory investigations. In contrast, the diagnosis of neuroborreliosis requires the assessment of serum and cerebrospinal fluid. Lyme arthritis is diagnosed in the presence of newly recognized arthritis and high-titer serum IgG antibodies against B. burgdorferi. The committee concludes the following recommendations: Borrelial serology should only be ordered in case of well-founded clinical suspicion for Lyme borreliosis, i.e., m...


Wednesday 4 July 2012

Solitary erythema migrans in children: comparison of treatment with clarithromycin and amoxicillin.

CONCLUSION: Clarithromycin and amoxicillin are equally effective and safe in treatment of children with solitary EM and have comparable side effects. PMID: 22760494 [PubMed - as supplied by publisher] (Source: Wiener Klinische Wochenschrift)


Monday 2 July 2012

Lyme disease support group expects more to attend this year

Organizer expects more to attend support group's monthly meetings as spread of Lyme disease is on the rise. (Source: SUNY Upstate Medical)


Monday 2 July 2012

Alice in Wonderland Syndrome and Lyme Disease

(Source: AAP Grand Rounds)

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Sunday 1 July 2012

White‐Tailed Deer (Odocoileus virginianus) as a Potential Sentinel for Human Lyme Disease in Indiana

In conclusion, WTD can be used as an accurate and cost‐effective sentinel for human LD. This method will permit public health workers to identify potentially endemic areas independently of human case reports. (Source: Zoonoses and Public Health)


Sunday 1 July 2012

Which forest bird species are the main hosts of the tick, Ixodes ricinus, the vector of Borrelia burgdorferi sensu lato, during the breeding season?

This study addressed individual and species factors that could explain the burden of Ixodes ricinus on forest birds during the reproductive periods of both vectors and hosts. The goal was to identify which bird species contribute the most to the tick population at the community level. Birds were mist-netted on four plots in 2008 and on seven plots in 2009 in two forests (Sénart and Notre Dame, near Paris, France). The dependence of the tick load per bird upon environmental conditions (questing nymph density, year and plot) and on host species traits (species, age, sex, body size, vertical space use, level of innate and acquired immunity) was analysed. Finally, the relative contribution of each bird species to the local dynamics of ticks was estimated, while accounting for their respective...


Sunday 1 July 2012

Infection due to Borrelia burgdorferi most likely does not occur in Cuba.

Authors: Dessau RB PMID: 22846137 [PubMed - in process] (Source: Braz J Infect Dis)


Sunday 1 July 2012

Serological evidences suggest Borrelia burgdorferi sensu lato infection in Cuba.

Authors: Rodríguez I, Fernández C, Sánchez L, Martínez B, Siegrist HH, Lienhard R PMID: 22846138 [PubMed - in process] (Source: Braz J Infect Dis)


Wednesday 27 June 2012

In Lyme Disease, Inflammatory Bacterial Deposits Remain After Antibiotic Treatment

Lyme disease is caused by the bacterial spirochete B. burgdorferi, which is transmitted to humans through tick bites. The disease typically begins with a skin rash and is followed by fever, joint pain, and other flu-like symptoms. If diagnosed early, Lyme disease can be successfully treated with antibiotics; however, up to 25% of patients experience arthritis-like symptoms after treatment. The cause of this condition, termed antibiotic refractory Lyme arthritis, is currently unknown. In the current issue of the JCI, researchers led by Dr... (Source: Health News from Medical News Today)

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Wednesday 27 June 2012

Seroprevalence of Lyme disease and genospecies of [i]Borrelia burgdorferi[/i] sensu lato in patients diagnosed with borreliosis in the Province of Warmia-Masuria in north-eastern Poland.

Seroprevalence of Lyme disease and genospecies of [i]Borrelia burgdorferi[/i] sensu lato in patients diagnosed with borreliosis in the Province of Warmia-Masuria in north-eastern Poland. Ann Agric Environ Med. 2012 Jun 27;19(2):203-7 Authors: Kubiak K, Dzika E, Równiak J, Dziedziech M, Dzisko J Abstract Between 2009-2010, a group of 259 patients suspected of contracting Lyme disease were examined in the Provincial Sanitary-Epidemiological Station in Olsztyn for the presence of IgM and IgG against specific Borrelia burgdorferi sensu lato (s.l.) genospecies antigens by immunoblot. A total of 27.4% and 29.0% of the blood serum samples showed positive and uncertain results for IgM and IgG antibodies. The majority of positive and uncertain results were found in patients aged 30...


Wednesday 27 June 2012

Serological survey in persons occupationally exposed to tick-borne pathogens in cases of co-infections with Borrelia burgdorferi, Anaplasma phagocytophilum, Bartonella spp. and Babesia microti.

Authors: Chmielewska-Badora J, Moniuszko A, Zukiewicz-Sobczak W, Zwoliński J, Piątek J, Pancewicz S Abstract Sera of 39 farmers, 119 foresters and 32 blood donors were investigated for the presence of antibodies against B. burgdorferi, A. phagocytophilum, B. microti and Bartonella spp. Semi-quantitative indirect immunofluorescence test was used to measure titers of anti-A. phagocytophilum, B. microti and Bartonella spp. IgG. ELISA test was used to measure titers of anti-B. burgdorferi IgM and IgG. B. burgdorferi was the most frequently observed among all the examined pathogens. 27.7% of farmers, 23.1% of forestry workers and 37.5% of control group were infected with Bartonella spp. Anti-A. phagocytophilum and anti-B. microti reactions were observed rarely. Sera of persons with si...


Wednesday 27 June 2012

Seroprevalence of [i]Leptospira[/i] spp. and [i]Borrelia burgdorferi[/i] sensu lato in Italian horses.

Authors: V Ebani V, Bertelloni F, Pinzauti P, Cerri D Abstract The aim of the study was to determine the seroprevalence of Leptospira spp. and Borrelia burgdorferi sensu lato in healthy horses living in 7 provinces of central Italy. In the period 2007-2009, sera from 386 horses were tested by microagglutination test (MAT) to detect antibodies to Leptospira spp., employing the following serovars as antigens: Bratislava, Ballum, Canicola, Icterohaemorrhagiae, Grippotyphosa, Hardjo, Pomona, Tarassovi. 3 animals were positive for the serovars Icterohaemorrhagiae, 2 to Bratislava, and 1 to Pomona, for a total 1.5% seroprevalence. All sera were examined by immunofluorence antibody test (IFAT) to reveal anti-B. burgdorferi s.l. antibodies. 94 (24.3%) horses were positive with antibody tit...


Monday 25 June 2012

Clinical prediction rule accurately identifies those at low risk for Lyme meningitis

Cohn KA, Thompson AD, Shah SS, Hines EM, Lyons TW, Welsh EJ, et al. Validation of a clinical prediction rule to distinguish Lyme meningitis from aseptic meningitis. Pediatrics 2012;129:e46-e53. (Source: The Journal of Pediatrics)


Monday 25 June 2012

Inflammatory bacterial deposits remain after antibiotic treatment

(Journal of Clinical Investigation) To investigate antibiotic-refractory arthritis associated with Lyme disease, Dr. Linda Bockenstedt at Yale University and colleagues reported on a fluorescent form of the bacteria that causes Lyme disease to determine what happens to the bacteria during and after antibiotic treatment. (Source: EurekAlert! - Infectious and Emerging Diseases)

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Sunday 24 June 2012

Foxes may hold key to Lyme disease spread

MILLBROOK, N.Y., June 24 (UPI) -- A decline in foxes, not an increase in the deer population, may be responsible for the explosion of Lyme disease in parts of the United States, researchers say. (Source: Health News - UPI.com)


Thursday 21 June 2012

Lyme disease experts fear disease explosion

A warming climate has health officials worried that tick populations are already spreading, bringing with them the germs that can lead to Lyme disease. (Source: CTV Health)


Tuesday 19 June 2012

Lyme Disease Outfoxes Deer

Deer ticks and Lyme disease go hand-in-hand in some places. But you can’t always put the blame on Bambi. Because new research shows that the incidence of Lyme disease tracks less with the abundance of deer than it does with the disappearance of foxes. The study is in the Proceedings of the National Academy of Sciences . [Taal Levi et al., " Deer, predators, and the emergence of Lyme disease "] [More] (Source: Scientific American - Official RSS Feed)


Monday 18 June 2012

Missing Foxes Fuel Lyme Disease Spread

As coyotes take over their ranges in North America, red fox populations are plummeting, and researchers have found one surprising result: The drop is fueling the spread of Lyme disease. [More] (Source: Scientific American - Official RSS Feed)

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Monday 18 June 2012

Worst Summer Yet for Lyme Disease? (CME/CE, with video)

(MedPage Today) -- The summer of 2012 may turn out to be the worst ever for Lyme disease in the northeastern United States because of recent shifts in the acorn and white-footed mouse populations, despite advances in treatment, researchers suggested. (Source: MedPage Today Infectious Disease)


Monday 18 June 2012

UC Santa Cruz researchers find increase in Lyme disease mirrors drop in red fox numbers

(University of California - Santa Cruz) A continued increase of Lyme disease in the United States, once linked to a recovering deer population, may instead be explained by a decline of the red fox, UC Santa Cruz researchers suggest in a new study. (Source: EurekAlert! - Infectious and Emerging Diseases)


Monday 18 June 2012

The Rise and Fall of the Lyme Disease Vaccines: A Cautionary Tale for Risk Interventions in American Medicine and Public Health

Conclusions: The social and psychological efficacy of many risk‐reducing practices and products, such as new “personalized vaccines,” is to provide insurance and reduce fear. Yet the actions of self‐interested actors can easily undermine this appeal. In addition to evaluating the scientific efficacy and safety of these practices and products, policymakers and others need to understand, anticipate, and perhaps shape the potential social and psychological work they might do. (Source: The Milbank Quarterly)


Thursday 14 June 2012

MurD enzymes from different bacteria: evaluation of inhibitors.

Authors: Barreteau H, Sosič I, Turk S, Humljan J, Tomašić T, Zidar N, Hervé M, Boniface A, Peterlin-Mašič L, Kikelj D, Mengin-Lecreulx D, Gobec S, Blanot D Abstract D-Glutamic acid-adding enzyme (MurD ligase) catalyses the addition of D-glutamic acid to UDP-N-acetylmuramoyl-L-alanine, an essential cytoplasmic step in the pathway for bacterial cell-wall peptidoglycan synthesis. As such, it represents an important antibacterial drug-discovery target enzyme. Recently, several series of compounds have been synthesised and found to inhibit MurD from Escherichia coli, the best one having an IC(50) value of 8μM. In the present work, we have tested twenty of these compounds against the MurD enzymes from Staphylococcus aureus, Streptococcus p...


Tuesday 12 June 2012

Risk factors for a non‐favorable outcome after treated European neuroborreliosis

ConclusionsDelayed treatment start, more symptoms and findings before treatment, and non‐complete recovery at 4 months after treatment are possible predictors of a poorer HRQoL and more fatigue 30 months after treated LNB. We did not find age, gender, educational level, involvement of the central nervous system, coexisting diseases, or cerebrospinal fluid findings to be associated with reduced HRQoL or fatigue. Our findings should be replicated in future studies before any conclusions can be drawn. (Source: Acta Neurologica Scandinavica)

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Monday 4 June 2012

Uncertainties In Diagnosing And Treating Lyme Disease [Letters]

(Source: Health Affairs)


Monday 4 June 2012

Misinformation About Lyme Disease [Letters]

(Source: Health Affairs)


Friday 1 June 2012

Lyme Disease Spirochete Encodes Manganese-dependent SOD [Metabolism]

In this study, we provide biochemical and genetic data showing that SodA is a manganese-dependent enzyme. First, B. burgdorferi contained SOD activity that is resistant to H2O2 and NaCN, characteristics associated with Mn-SODs. Second, the addition of manganese to the Chelex-treated BSK-II enhanced SodA expression. Third, disruption of the manganese transporter gene bmtA, which significantly lowers the intracellular manganese, greatly reduced SOD activity and SodA expression, suggesting that manganese regulates the level of SodA. In addition, we show that B. burgdorferi is resistant to streptonigrin, a metal-dependent redox cycling compound that produces ROS, and that SodA plays a protective role against the streptonigrin. Taken together, our data demonstrate the Lyme disease spirochete en...


Friday 1 June 2012

Borrelia burgdorferi malQ mutants utilize disaccharides and traverse the enzootic cycle

AbstractBorrelia burgdorferi, the causative agent of Lyme borreliosis, cycles in nature between a vertebrate host and a tick vector. We demonstrate that B. burgdorferi can utilize several sugars that may be available during persistence in the tick, including trehalose, N‐acetylglucosamine (GlcNAc) and chitobiose. The spirochete grows to a higher cell density in trehalose, which is found in tick hemolymph, than in maltose; these two disaccharides differ only in the glycosidic linkage between the glucose monomers. Additionally, B. burgdorferi grows to a higher density in GlcNAc than in the GlcNAc dimer chitobiose, both of which may be available during tick molting. We have also investigated the role of malQ (bb0166), which encodes an amylomaltase, in sugar utilization during the enzootic c...


Thursday 31 May 2012

Borrelia burgdorferi Visualized in Ixodes scapularis Tick Excrement by Immunofluorescence

Vector-Borne and Zoonotic Diseases , Vol. 0, No. 0. (Source: Vector-Borne and Zoonotic Diseases)

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Tuesday 29 May 2012

New Ticks Spread Across Southeast, Diseases Rise

In the trees and grasses of the South, there are a growing number of unwanted visitors that at best are an itchy nuisance and at worst can carry debilitating diseases: Ticks. Public health officials say that numbers of reported cases of diseases like Lyme disease and Rocky Mountain spotted fever are not yet alarming and have not yet shown a definitive trend upward from a national perspective. But they do worry that more ticks means more of a risk that those diseases will spike. (Source: RWJF News Digest - Public Health)


Monday 28 May 2012

Subject Index

Absences, and eyelid myoclonia, in a child with l-2 hydroxyglutaric aciduria: findings of MRI, 195 Alice in Wonderland syndrome, lyme neuroborreliosis presenting as, 185 (Source: Pediatric Neurology)


Friday 25 May 2012

Tick Talk: Lyme Disease Under The Microscope

Banking giant JPMorgan's multibillion-dollar trading loss is blamed on an executive's absence due to Lyme disease. And a mild winter has some scientists predicting a busy tick season ahead. A panel of experts discuss how the infection is contracted, why it's often misdiagnosed and the most effective treatment options.» E-Mail This     » Add to Del.icio.us (Source: NPR Health and Science)


Thursday 24 May 2012

MyViewPoints: Sharing information, connecting communities

Adrienne found online communities helpful when recovering from Lyme disease About two years ago I became very sick. After dealing with illness for a number of months I was finally diagnosed with Lyme disease. Suddenly I had an explanation for all the symptoms I was feeling: aches and pains, headaches, blurred vision, dizziness, memory loss, upset stomachs, anxiety, depression. I was lucky to find a great local doctor and have a supportive network of friends and family to lean on. I took my prescribed antibiotics and felt better. I took time off from work and gave my body time to heal. Both played into my eventual recovery, as did the support network I found online. By connecting with an online Lyme disease community I learned what hurdles other people like me were facing, and how they bea...


Thursday 24 May 2012

New test shows potential for detecting active cases of Lyme disease

(George Mason University) George Mason University researchers can find out if a tick bite means Lyme disease well before the bite victim begins to show symptoms. (Source: EurekAlert! - Infectious and Emerging Diseases)


Thursday 24 May 2012

Detection of Borrelia burgdorferi sensu lato in endomyocardial biopsy specimens in individuals with recent-onset dilated cardiomyopathy

Conclusion Myocardial persistence of BBSL may be involved in the pathophysiology of DCM in individuals living in areas in which Lyme disease is endemic. (Source: European Journal of Heart Failure)


Thursday 24 May 2012

Reading between the Lyme: is Borrelia burgdorferi a cause of dilated cardiomyopathy? The debate continues

(Source: European Journal of Heart Failure)

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Thursday 24 May 2012

Critical Analysis of Treatment Trials of Rhesus Macaques Infected with Borrelia burgdorferi Reveals Important Flaws in Experimental Design

Vector-Borne and Zoonotic Diseases , Vol. 0, No. 0. (Source: Vector-Borne and Zoonotic Diseases)


Wednesday 23 May 2012

Lyme disease in a British referral clinic

Conclusions: A minority of referred patients had LD, while a third had CFS. LD is over-diagnosed by non-specialists, reflecting the complexities of clinical and/or laboratory diagnosis. Patients with CFS were susceptible to misdiagnosis in non-NHS settings, reinforcing concerns about missed opportunities for appropriate treatment for this group and about the use of inappropriate diagnostic modalities and anti-microbials in non-NHS settings. (Source: QJM)


Friday 18 May 2012

Tick-Borne Illnesses: An Overview

Over the past several decades, tick-borne illnesses have become more widespread throughout the US because of such factors as climate change, increasing numbers of animal reservoirs and tick vectors, suburban development, and participation in outdoor recreational activities. Despite the availability of low-cost and effective antibiotics, these infections continue to cause severe illness in adults and children. Tick-borne illnesses in the USA are clinically similar, but epidemiologically and etiologically distinct, illnesses. The more commonly encountered infections include Lyme disease, human anaplasmosis (human granulocytic anaplasmosis), human ehrlichiosis (human monocytic ehrlichiosis), babesiosis, and Rocky Mountain spotted fever. The infecting organisms are maintained in natural cycles...

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Friday 18 May 2012

Lyme Disease

Lyme disease is the most common vector-borne illness in the USA. It was originally described in 1976 after an unusual cluster of juvenile rheumatoid arthritis cases in Lyme, CT. The causative agent of Lyme disease is the tick-borne spirochete Borrelia burgdorferi, which is transmitted through the bite of the tick species, Ixodes scapularis, in the northeastern and north central USA and Ixodes pacificus in the Western USA. Lyme disease is a multisystem illness with variable clinical presentations and most often involves the skin, joints, nervous system, and heart. After infection, some patients may have disease localized to the skin, whereas others may only present with later illness, such as arthritis. Early cutaneous findings of erythema migrans (EM) in the right clinical setting are usua...


Friday 18 May 2012

Babesiosis

is a tick-borne illness caused by the protozoa Babesia, an obligate parasite of red blood cells that produces a malaria-like illness. It is transmitted by the tick, Ixodes scapularis, which is also the vector of Lyme disease and anaplasmosis. Over the past 50 years, Babesia sp increasingly has been identified as a cause of human infection. The first cases of babesiosis were reported in Europe in 1956 and in the US in 1966. Most cases of human babesiosis occur during the summer months and are endemic in the northeastern US, including Massachusetts, Rhode Island, Connecticut, and New York. Outbreaks have also occurred in Wisconsin, Minnesota, California, and Washington. In the US, most clinically apparent disease occurs primarily in those patients with advanced age or those with underlying ...


Friday 18 May 2012

Prevention of Tick-Borne Illness

Lyme disease and other tick-borne illnesses have become increasingly common in the US. Suburban development, adventurous habits, and increased recognition are likely all responsible for these trends. In 2010, nearly 30,000 cases of Lyme disease were reported to the Centers for Disease Control and Prevention (CDC). Clinicians seeking to advise patients regarding the prevention of Lyme and the other tick-borne illnesses are challenged by a complex field at the intersection of vector biology, microbiology, and infectious disease. (Source: Disease a Month)


Friday 18 May 2012

Impacts of an Introduced Forest Pathogen on the Risk of Lyme Disease in California

Vector-Borne and Zoonotic Diseases , Vol. 0, No. 0. (Source: Vector-Borne and Zoonotic Diseases)


Friday 18 May 2012

Seasonality of Ixodes ricinus Ticks on Vegetation and on Rodents and Borrelia burgdorferi sensu lato Genospecies Diversity in Two Lyme Borreliosis–Endemic Areas in Switzerland

Vector-Borne and Zoonotic Diseases , Vol. 0, No. 0. (Source: Vector-Borne and Zoonotic Diseases)

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Wednesday 16 May 2012

Development and Application of a Loop‐mediated Isothermal Amplification Assay for Rapid Detection of Borrelia burgdorferi s. l. in Ticks

SummaryA loop‐mediated isothermal amplification (LAMP) assay was developed to detect Borrelia burgdorferi s. l. in ticks, which is a pathogen that causes Lyme disease. Cross‐reactions with Chlamydia psittaci, Mycoplasma mycoides subsp. capri and some tick‐borne pathogens were excluded. Analytical sensitivity of LAMP showed its detection limit was from 0.02 to 0.2 pg of DNA in detection of the reference samples at 65°C for 40 min. The performance of LAMP was assessed by testing 110 samples from susceptible tick species and comparing the results with conventional and nested PCR tests previously described. The results demonstrated that LAMP was significantly more sensitive than the conventional PCR (32.7% versus 15.5%, P < 0.05) and slightly more sensitive, although not sign...


Wednesday 16 May 2012

CXCL13 is the major determinant for B cell recruitment to the CSF during neuroinflammation

Conclusions: CXCL13 seems to be the major determinant for B cell recruitment to the CNS compartment in different neuroinflammatory diseases. Thus, elevated CSF CXCL13 levels rather reflect a strong humoral immune response in the CNS compartment than being specific for a particular disease entity. (Source: Journal of Neuroinflammation)


Wednesday 16 May 2012

Intravenous antibiotics used in dermatology

ABSTRACTIt is not common for dermatologists to use intravenous antibiotics in daily practice. However, there are several serious infections that may come to the attention of a dermatologist because of cutaneous signs and symptoms. It is important for dermatologists to be familiar with the presenting symptoms, various stages of disease, and treatment for such infections, as good outcomes are achieved by early recognition and use of appropriate therapy. The following section reviews the treatment, with a focus on intravenous antimicrobial therapy, for several serious infections important to dermatologists: syphilis, Rocky Mountain spotted fever, Lyme disease, cellulitis, methicillin‐resistant Staphylococcus aureus, Vibrio vulnificans, and necrotizing fasciitis. (Source: Dermatologic Therap...


Monday 14 May 2012

BORRELIA REMEDY (Borrelia Burgdorferi,) Liquid [Deseret Biologicals, Inc.]

Updated Date: May 14, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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Friday 11 May 2012

B. burgdorferi Plasminogen Receptor [Cell Biology]

Host-derived proteases are crucial for the successful infection of vertebrates by several pathogens, including the Lyme disease spirochete bacterium, Borrelia burgdorferi. B. burgdorferi must traverse tissue barriers in the tick vector during transmission to the host and during dissemination within the host, and it must disrupt immune challenges to successfully complete its infectious cycle. It has been proposed that B. burgdorferi can accomplish these tasks without an endogenous extra-cytoplasmic protease by commandeering plasminogen, the highly abundant precursor of the vertebrate protease plasmin. However, the molecular mechanism by which B. burgdorferi immobilizes plasminogen to its surface remains obscure. The data presented here demonstrate that the outer surface protein C (OspC) of ...


Wednesday 9 May 2012

Comparison of five diagnostic modalities for direct detection of Borrelia burgdorferi in patients with early Lyme disease

In this study, we evaluated the sensitivity of 5 direct diagnostic methods (culture and nested polymerase chain reaction [PCR] of a 2-mm skin biopsy specimen, nested PCR and quantitative PCR (qPCR) performed on the same 1-mL aliquot of plasma and a novel qPCR–blood culture method) in 66 untreated adult patients with erythema migrans. Results of one or more of these tests were positive in 93.9% of the patients. Culture was more sensitive than PCR for both skin and blood, but the difference was only statistically significant for blood samples (P (Source: Diagnostic Microbiology and Infectious Disease)


Tuesday 8 May 2012

Whose Lyme is it anyway? Subject positions and the construction of responsibility for managing the health risks from Lyme disease.

This study examined how the responsibility for managing and communicating the health risks from Lyme disease to forest workers and recreational visitors was constructed and acted upon by 21 interviewees in key managerial positions within one of the largest UK forestry organisations. The in-depth, semi-structured interviews were analysed using discourse analysis within a Foucauldian framework. The results demonstrated that the construction of responsibility towards the workforce and visitors was embedded into broader representations of the forest as a working, recreational and natural environment, as well as into the binary conceptualisation of forest hazards as natural and human-made. These constructions prescribed respective subject positions which differentially informed assumptions of r...


Monday 7 May 2012

Evaluation of commercial screening tests and blot assays for the diagnosis of Lyme borreliosis

Abstract: The performance of 4 screening tests and 10 blot assays for the serologic diagnosis of Lyme borreliosis in a Belgian population was evaluated. A total of 196 sera were tested: 36 Lyme borreliosis at different stages of the disease, 50 healthy blood donors, and 110 representing various clinical circumstances. The DiaSorin Liaison and Euroimmun Anti-Borrelia screening tests were evaluated. The tested blot assays were Virotech Borrelia LINE tests WE222, WE225, and WE224, as well as Mikrogen recomLine Borrelia and Viramed ViraStripe. The specificity of IgG was acceptable for the different assays. For IgM, DiaSorin Liaison Borrelia IgM Quant, Mikrogen recomLine, and Viramed ViraStripe lacked specificity. Interestingly, a higher rate of falsely reactive samples was observed in the grou...


Wednesday 2 May 2012

Ötzi the Iceman scientists find 5,000-year-old blood sample

Oldest blood sample ever retrieved sheds new light on Ötzi's death and may help improve understanding of blood agingAs cold cases go, it does not get much colder than Ötzi the Iceman, whose body was found frozen solid in the Italian Alps 5,300 years after he died from an arrow wound.Since he was discovered by trekkers in 1991, scientists have mapped his DNA and figured out everything from what ailments he suffered from (Lyme disease and a weak heart) to the last meal he ate (venison and ibex) before he was shot in the back, probably by an enemy tribesman.Now, using advanced nanotechnology, they have located traces of Ötzi's blood, the oldest blood sample ever retrieved. The discovery sheds new light on his death and may change the way police study blood found at modern crime scenes."Up ...

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Wednesday 2 May 2012

Ötzi the Iceman: scientists find 5,000-year-old blood sample

Oldest blood sample ever retrieved sheds new light on Ötzi's death and may help improve understanding of blood agingAs cold cases go, it does not get much colder than Ötzi the Iceman, whose body was found frozen solid in the Italian Alps 5,300 years after he died from an arrow wound.Since he was discovered by trekkers in 1991, scientists have mapped his DNA and figured out everything from what ailments he suffered from (Lyme disease and a weak heart) to the last meal he ate (venison and ibex) before he was shot in the back, probably by an enemy tribesman.Now, using advanced nanotechnology, they have located traces of Ötzi's blood, the oldest blood sample ever retrieved. The discovery sheds new light on his death and may change the way police study blood found at modern crime scenes."Up ...


Wednesday 2 May 2012

Study on Ticks and Tick‐Borne Zoonoses in Public Parks in Italy

In this study, B. clarridgeiae was for the first time identified in I. ricinus ticks. (Source: Zoonoses and Public Health)


Tuesday 1 May 2012

Clinical evidence for rapid transmission of Lyme disease following a tickbite: response to Piesman and Gray

We appreciate the interest of Piesman and Gray in our clinical report of Lyme disease transmission within 24 h of a tickbite (), and we are grateful for the opportunity to provide additional information that supports our clinical observation of rapid transmission of Borrelia burgdorferi, the spirochetal agent of Lyme disease, to our patients. (Source: Diagnostic Microbiology and Infectious Disease)

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Tuesday 1 May 2012

Letter in response to the Hynote article

This article is markedly deficient in data that allow critical evaluation of the author's contention that Lyme disease can be spread with only a brief encounter with a tick. (Source: Diagnostic Microbiology and Infectious Disease)


Tuesday 1 May 2012

Lack of evidence for rapid transmission of Lyme disease following a tick bite

We read with interest the recent article by Hynote et al. () describing the potential transmission of Borrelia burgdorferi to three patients following short-term ( (Source: Diagnostic Microbiology and Infectious Disease)


Tuesday 1 May 2012

Amplification of the flgE gene provides evidence for the existence of a Brazilian borreliosis.

CONCLUSION: These results support the existence of borreliosis in Brazil. However, it is unclear whether this borreliosis is caused by a genetically modified B. burgdorferi sensu stricto or by a new species of Borrelia spp. PMID: 22634887 [PubMed - in process] (Source: Revista do Instituto de Medicina Tropical de Sao Paulo)


Monday 30 April 2012

Delays and Diversions Mark the Development of B Cell Responses to Borrelia burgdorferi Infection.

This study aimed to further investigate the humoral response to B. burgdorferi and its degree of T cell dependence, with the ultimate goal of elucidating the mechanisms underlying the failure of effective immunity to this emerging infectious disease agent. Our study identifies distinct stages in the B cell response using a mouse model, all marked by the generation of unusually strong and persistent T-dependent and T-independent IgM Abs. The initial phase is dominated by a strong T-independent accumulation of B cells in lymph nodes and the induction of specific Abs in the absence of germinal centers. A second phase begins around week 2.5 to 3, in which relatively short-lived germinal centers develop in lymph nodes, despite a lymph node architecture that lacks clearly demarcated T and B cell...


Saturday 28 April 2012

The Role of Borrelia burgdorferi Outer Surface Proteins

AbstractHuman pathogenic spirochetes causing Lyme disease belong to the Borrelia burgdorferi sensu lato complex. B. burgdorferi organisms are extracellular pathogens transmitted to humans through the bite of Ixodes spp. ticks. These spirochetes are unique in that they can cause chronic infection and persist in the infected human, even though a robust humoral and cellular immune response is produced by the infected host. How this extracellular pathogen is able to evade the host immune response for such long periods of time is currently unclear. To gain a better understanding of how this organism persists in the infected human, many laboratories have focused on identifying and characterizing outer surface proteins of B. burgdorferi. Since the interface between B. burgdorferi and its human ho...


Friday 27 April 2012

Tick salivary secretion as a source of antihemostatics.

Authors: Chmelar J, Calvo E, Pedra JH, Francischetti IM, Kotsyfakis M Abstract Ticks are mostly obligatory blood feeding ectoparasites that have an impact on human and animal health. In addition to direct damage due to feeding, some tick species serve as the vectors for the causative agents of several diseases, such as the spirochetes of the genus Borrelia causing Lyme disease, the virus of tick-borne encephalitis, various Rickettsial pathogens or even protozoan parasites like Babesia spp. Hard ticks are unique among bloodfeeders because of their prolonged feeding period that may last up to two weeks. During such a long period of blood uptake, the host develops a wide range of mechanisms to prevent blood loss. The arthropod ectoparasite, in turn, secretes saliva in the sites of bit...


Thursday 26 April 2012

Bartonella spp. Bacteremia and Rheumatic Symptoms in Patients from Lyme Disease-endemic Region.

Authors: Maggi RG, Mozayeni BR, Pultorak EL, Hegarty BC, Bradley JM, Correa M, Breitschwerdt EB Abstract Bartonella spp. infection has been reported in association with an expanding spectrum of symptoms and lesions. Among 296 patients examined by a rheumatologist, prevalence of antibodies against Bartonella henselae, B. koehlerae, or B. vinsonii subsp. berkhoffii (185 [62%]) and Bartonella spp. bacteremia (122 [41.1%]) was high. Conditions diagnosed before referral included Lyme disease (46.6%), arthralgia/arthritis (20.6%), chronic fatigue (19.6%), and fibromyalgia (6.1%). B. henselae bacteremia was significantly associated with prior referral to a neurologist, most often for blurred vision, subcortical neurologic deficits, or numbness in the extremities, whereas B. koehlerae bact...

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Thursday 26 April 2012

[Correspondence] Lyme disease antiscience – Authors' reply

Although we support efforts to educate clinicians and the public alike with high-quality, evidence-based information about infection with Borrelia burgdorferi, the comments from Stella Huyshe-Shires regarding our Personal View misleadingly suggest that the UK is untainted by antiscience concerns. A report by Cottle and colleagues showed that most patients referred to an infectious diseases unit in Liverpool, UK, for Lyme disease (n=115) did not have the disorder. Of 38 patients with chronic fatigue syndrome, 45% were incorrectly labelled as having chronic Lyme disease by alternative practitioners. (Source: The Lancet Infectious Diseases)


Thursday 26 April 2012

[Correspondence] Lyme disease antiscience

Paul Auwaerter and colleagues' Personal View outlines an extremely uncomfortable situation in the USA, but this report should not lead anyone to believe that the situation in the UK is the same. Dissection of this opinion piece only adds to the divisiveness. Instead it should be pointed out that, in the UK, doctors rather than patients are misusing science. (Source: The Lancet Infectious Diseases)


Thursday 26 April 2012

Reinventing the Reel Presentation (Alan Lyme MSW)

Seattle Conference presentation material for facilitators/teachers of Motivational Interviewing skills. (Source: Family Medicine Digital Resources Library (FMDRL) Recently Uploaded)

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Thursday 26 April 2012

Association of a toll‐like receptor 1 polymorphism with heightened Th1 inflammatory responses and antibiotic‐refractory Lyme arthritis

ConclusionThe TLR1‐1805GG polymorphism in B burgdorferi RST1–infected patients was associated with stronger Th1‐like inflammatory responses, an environment that may set the stage for antibiotic‐refractory arthritis. (Source: Arthritis and Rheumatism)


Thursday 26 April 2012

The association of lumbar intervertebral disc degeneration on magnetic resonance imaging with body mass index in overweight and obese adults: A population‐based study

ConclusionOur findings, in one of the largest studies to systematically assess lumbar disc degeneration on MRI, indicated a significant association between the presence, extent, and global severity of disc degeneration with weight in overweight and obese adults. (Source: Arthritis and Rheumatism)


Thursday 26 April 2012

The toll of a TLR1 polymorphism in lyme disease: A tale of mice and men

(Source: Arthritis and Rheumatism)


Tuesday 24 April 2012

Worried It Might be Lyme Disease? Consumers Can Go to Virtuwell.com for Online Diagnosis, Treatment

MINNEAPOLIS, April 24, 2012 (GLOBE NEWSWIRE) -- With an early start to the tick season, consumers can go to virtuwell.com to get a diagnosis and treatment for Lyme disease, the most common tick-borne illness. More than 900 cases of Lyme disease are reported each year in Minnesota according to the Minnesota Department of Health. (Source: Medical News (via PRIMEZONE))


Tuesday 24 April 2012

Variable regions in the sushi domains 6-7 and 19-20 of factor H in animals and human lead to change in the affinity to factor H binding protein of Borrelia.

This article is part of a Special Issue entitled: Farm animal proteomics. PMID: 22546488 [PubMed - as supplied by publisher] (Source: Journal of Proteomics)

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Monday 23 April 2012

A possible role for inflammation in mediating apoptosis of oligodendrocytes as induced by the Lyme disease spirochete Borrelia burgdorferi

Conclusions: This finding supports our hypothesis that the inflammatory response elicited by the Lyme disease spirochete in glial cells contributes to neural cell damage. As oligodendrocytes are vital for the functioning and survival of neurons, the inflammation and subsequent apoptosis of oligodendrocytes induced by B. burgdorferi could contribute to the pathogenesis of Lyme neuroborreliosis. (Source: Journal of Neuroinflammation)


Saturday 21 April 2012

Cure unwanted? Exploring the chronic Lyme disease controversy and why conflicts of interest in practice guidelines may be guiding us down the wrong path.

Authors: Ferguson J PMID: 22497097 [PubMed - in process] (Source: American Journal of Law and Medicine)


Friday 20 April 2012

BB0324 and BB0028 are constituents of the Borrelia burgdorferi beta-barrel assembly machine (BAM) complex

Conclusions: The combined data suggest that the BAM complex of B. burgdorferi contains unique protein constituents which differ from those found in other proteobacterial BAM complexes. The novel findings now allow for the B. burgdorferi BAM complex to be further studied as a model system to better our understanding of spirochetal OM biogenesis in general. (Source: BMC Microbiology - Latest articles)


Thursday 19 April 2012

More bugs and bites? Protect your child from ticks and mosquitoes this season

We’re not the only ones who enjoyed the record-setting mild winter—ticks and mosquitoes have too. While normal winters produce hard freezes that kill off these pests or make them dormant, unseasonably warm temperatures allowed adult mosquitoes and ticks to live through it, creating early arrival and a potential population boom for some types of bugs. So how can you prepare your family for the early onslaught of ticks and mosquitoes? “Prevention is key,” says Catherine Lachenauer, MD, director of Infectious Diseases Outpatient Practice at Boston Children’s Hospital. “Avoid areas at the edge of the woods with long grasses. Also, wearing long, light-colored clothing helps keep ticks from getting on the skin and makes it easier to recognize one on your body.” Ticks: An early ...


Tuesday 17 April 2012

FDA to rule on testing of Lyme disease drug

The Food and Drug Administration is expected to soon decide whether VGV-L, a drug candidate from Viral Genetics targeting chronic Lyme disease, can move to human trials. (Source: Modern Medicine)

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Monday 16 April 2012

Surprising Study Results: More Cattle Means Less Lyme Disease

The abundance of cattle is the primary influence on the prevalence of two tick-borne pathogens, according to a paper in the April Applied and Environmental Microbiology. One of these, Anaplasma phagocytophilum, causes human granulocytic anaplasmosis, and the other, Borrelia burgdorferi, causes Lyme disease. Read more... (Source: American Society for Microbiology)


Monday 16 April 2012

Tips from the journals of the American Society for Microbiology

(American Society for Microbiology) In this month's issue: "More Cattle Means Less Lyme Disease;" "Texas Girl Loses Leg to Rare Thai Fungus;" "Gut Microbes of Cockroaches and Termites Compared;" and "Cyanobacterium Demonstrates Promise for Biotechnology Feedstock Production." (Source: EurekAlert! - Infectious and Emerging Diseases)


Wednesday 11 April 2012

Evaluation of molecular methods for detection of Borrelia burgdorferi senso lato in ticks

In this study, 4 PCR methods, based on the OspA, flagellin, rrs, and P66 genes, for detection of B. burgdorferi s. l. were evaluated by detection of genomic DNA from 3 reference genospecies and tick samples. The sensitivity of the PCR methods was analyzed using serially diluted gDNA from B. afzelii (Bo23), B. burgdorferi sensu stricto (B31), and B. garinii (PBi). The performance of the PCRs was evaluated by detection of the gDNA of 543 ticks. The results showed that the PCRs targeting the OspA gene, fla gene, rrs gene, and P66 gene detected 37 (6.8%), 74 (13.6%), 16 (2.9%), and 14 (2.6%) tick samples, respectively. The PCR targeting the fla gene was the most sensitive method for the detection of B. burgdorferi s. l. (Source: Diagnostic Microbiology and Infectious Disease)


Thursday 5 April 2012

Well: Think Like a Doctor: A Crooked Walk

Can you solve a medical mystery involving a 27-year-old woman with an odd gait and progressive weakness in her hips and legs? (Source: NYT)


Sunday 1 April 2012

Lyme disease - the challenge for patients.

Authors: Huyshe-Shires SR, Pearson S Abstract No abstract available. PMID: 22516583 [PubMed - as supplied by publisher] (Source: The Netherlands Journal of Medicine)

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Sunday 1 April 2012

Lyme neuroretinitis in singapore: a diagnostic dilemma.

Authors: Lam JSh, Sanjay S PMID: 22635283 [PubMed - in process] (Source: Annals of the Academy of Medicine, Singapore)


Wednesday 28 March 2012

Re: Risk of malignancy associated with lyme disease: Still up in the air

(Source: International Journal of Cancer)


Wednesday 28 March 2012

INC Research to Close and Lay Off Most Employees

Old Lyme Company to Close and Lay Off Most Employees [the Day, New London, Conn.] From Day, The (New London, CT) (March 27, 2012) March 27--OLD LYME -- INC Research LLC, which announced the acquisition of Kendle International Inc. last spring, is... (Source: Drugs.com - Pharma News)


Wednesday 28 March 2012

Health experts warn of hidden spread of Lyme disease

The number of Lyme disease cases in England and Wales has almost trebled since 2002 with experts warning the true number of people affected by the infection from ticks could be much higher. (Source: Telegraph Health)


Wednesday 28 March 2012

Risk of malignancy associated with lyme disease: Still up in the air

(Source: International Journal of Cancer)


Wednesday 28 March 2012

Re: Risk of malignancy associated with lyme disease: Still up in the air

(Source: International Journal of Cancer)


Wednesday 28 March 2012

Risk of malignancy associated with lyme disease: Still up in the air

(Source: International Journal of Cancer)

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Tuesday 27 March 2012

Minimal-Change Disease Secondary to Borrelia burgdorferi Infection

Lyme borreliosis is a chronic illness caused by tick-transmitted spirochete Borrelia burgdorferi. Borreliosis can be extremely threatening if it is not diagnosed and treated in early stages. Kidneys are not typically involved in the disease. However, in infected dogs, Lyme nephritis is present in 5–10% of cases. It is associated with rapidly progressing renal failure. Histopathological examination shows mesangial proliferative glomerulonephritis with diffuse tubular necrosis, (Dambach et al. (1997)). In available literature, there were reports of human's glomerulonephritis associated with Borrelia burgdorferi infection. These cases refer to membranous and mesangial proliferative glomerulonephritis (Kirmizis and Chatzidimitriou (2010), Zachäus (2008), and Kirmizis et al. ...


Tuesday 27 March 2012

Clinical Images: Toe dactylitis revealing late Lyme borreliosis

(Source: Arthritis and Rheumatism)


Tuesday 27 March 2012

Prevalence of Dirofilaria immitis, Ehrlichia canis, Borrelia burgdorferi sensu lato, Anaplasma spp. and Leishmania infantum in apparently healthy and CVBD-suspect dogs in Portugal - a national serological study

Seroprevalence of infection with or exposure to Dirofilaria immitis, Ehrlichia canis, Borrelia burgdorferi sensu lato, Anaplasma spp. and Leishmania infantum was assessed in dogs from Portugal. Results are expected to give veterinarians and public health authorities an increased awareness on canine vector-borne diseases and to promote control actions. Image: Map of Portugal over vector arthropods and agents of canine vector-borne diseases. (Source: Parasites and Vectors)

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Tuesday 27 March 2012

Clinical Images: Toe dactylitis revealing late Lyme borreliosis

(Source: Arthritis and Rheumatism)


Tuesday 27 March 2012

Borrelia burgdorferi Serosurvey in Wild Deer in England and Wales

Vector-Borne and Zoonotic Diseases , Vol. 0, No. 0. (Source: Vector-Borne and Zoonotic Diseases)


Monday 26 March 2012

Development of Real-Time Polymerase Chain Reaction for Detection of Borrelia burgdorferi sensu lato in China

Vector-Borne and Zoonotic Diseases , Vol. 0, No. 0. (Source: Vector-Borne and Zoonotic Diseases)


Monday 26 March 2012

HPA advises public to be 'tick aware' to reduce the risk of Lyme disease

The Health Protection Agency (HPA) is reminding people to be ‘tick aware’ this year and take sensible precautions to reduce their risk of Lyme disease, as Tick Bite Prevention Week (26 March – 1 April) begins. (Source: Health Protection Agency)


Monday 26 March 2012

Effect of Surveillance on Characteristics of Lyme DiseaseEffect of Surveillance on Characteristics of Lyme Disease

The epidemiology of Lyme disease may be subject to variation by surveillance method. Emerging Infectious Diseases (Source: Medscape Today Headlines)

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Friday 23 March 2012

Lyme Disease Pushes Northward

Lyme disease may surge this year in the northeastern United States and is already spreading into Canada from a confluence of factors including acorns, mice and the climate.The illness is transmitted from mice and deer to humans via bites from the black-legged tick, Ixodes scapularis , usually in forested areas. According to the Centers for Disease Control and Prevention (CDC), Lyme disease is the most commonly reported vector-borne illness in the United States. [More] (Source: Scientific American - Official RSS Feed)


Friday 23 March 2012

[Signs and significance of a tick-bite: psychiatric disorders associated with Lyme disease].

Authors: Sno HN Abstract <span class="subtitle">summary</span> <span class="subtitle">background </span>In view of the increased prevalence of Lyme disease and the increased attention given to the disease in the media, psychiatrists are more likely to be confronted with patients with psychiatric disorders that may be linked to Lyme disease. <span class="subtitle">aim </span>To present an overview of some diagnostic problems and psychiatric disorders that can occur in the context of Lyme disease. <span class="subtitle">method</span> The literature was reviewed systematically with the help of Medline and Embase for the period 1990-October 2010 and relevant articles were studied that were mentioned in the reference lists of the articles ...


Friday 23 March 2012

Activation of the RpoN-RpoS regulatory pathway during the enzootic life cycle of Borrelia burgdorferi

Conclusion: Our study demonstrates that the RpoN-RpoS regulatory pathway is initially activated during the tick transmission of B. burgdorferi to its mammalian host, and is sustained during mammalian infection. (Source: BMC Microbiology - Latest articles)


Wednesday 21 March 2012

Northeast U.S. Should Brace for Spike in Lyme Disease: Expert

Title: Northeast U.S. Should Brace for Spike in Lyme Disease: ExpertCategory: Health NewsCreated: 3/20/2012 6:06:00 PMLast Editorial Review: 3/21/2012 12:00:00 AM (Source: MedicineNet Hepatitis C General)


Tuesday 20 March 2012

Northeast U.S. Should Brace for Spike in Lyme Disease

The reason is a steep drop in mouse populations, a tick's preferred host Source: HealthDay Related MedlinePlus Page: Lyme Disease (Source: MedlinePlus Health News)


Tuesday 20 March 2012

Boom-And-Bust Acorn Crops And A Decline In Mice Leave Humans Vulnerable To Lyme Disease Infected Ticks

The northeastern U.S. should prepare for a surge in Lyme disease this spring. And we can blame fluctuations in acorns and mouse populations, not the mild winter. So reports Dr. Richard S. Ostfeld, a disease ecologist at the Cary Institute of Ecosystem Studies in Millbrook, NY. What do acorns have to do with illness? Acorn crops vary from year-to-year, with boom-and-bust cycles influencing the winter survival and breeding success of white-footed mice... (Source: Health News from Medical News Today)


Tuesday 20 March 2012

Acute Heart Failure From Lyme Carditis [Images and Case Reports in Heart Failure]

(Source: Circulation: Heart Failure)


Monday 19 March 2012

Health roundup: Lyme season may be early

Ticks carrying Lyme disease may be out early, thanks to mild winter. Also: students play dangerous choking game, gyms stay open all night. (Source: USATODAY.com Health)


Monday 19 March 2012

A Mild Winter Means a Longer Tick Season

Entomologists say that an explosion of the tick population is unlikely, but just like humans and dogs, ticks appear to be enjoying the great outdoors a little earlier this year. (Source: NYT Health)

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Monday 19 March 2012

Letter in response to the Hynote article

The series of case reports presented in the article “Clinical evidence for rapid transmission of Lyme disease following a tickbite” by purports to question the observation that risk of transmission of Lyme disease spirochetes by ticks is closely related to the duration of tick attachment. In both laboratory and controlled clinical trials, the longer ticks are attached the more likely they are to transmit infectious spirochetes. This holds true for Ixodes scapularis, the principal tick vector in eastern North America (); I. pacificus, in western North America (); and I. ricinus, in Europe (). In addition, the risk of transmission appears to be extremely low when ticks are attached for (Source: Diagnostic Microbiology and Infectious Disease)


Sunday 18 March 2012

Surge in Lyme Disease Predicted for Northeastern U.S.

The northeastern U.S. should prepare for a surge in Lyme disease this spring. And we can blame fluctuations in acorns and mouse populations, not the mild winter. So reports Dr. Richard S. Ostfeld, a disease ecologist at the Cary Institute of Ecosystem Studies in Millbrook, NY. (Source: Disabled World)


Friday 16 March 2012

Lyme disease surge predicted for Northeastern US: Due to acorns and mice, not mild winter

The northeastern US should prepare for a surge in Lyme disease this spring. And we can blame fluctuations in acorns and mouse populations, not the mild winter. (Source: ScienceDaily Headlines)


Friday 16 March 2012

Lyme disease surge predicted for the northeastern US

(Cary Institute of Ecosystem Studies) The northeastern US should prepare for a surge in Lyme disease this spring. And we can blame fluctuations in acorns and mouse populations, not the mild winter. So reports Dr. Richard S. Ostfeld, a disease ecologist at the Cary Institute of Ecosystem Studies in Millbrook, N.Y. (Source: EurekAlert! - Biology)


Thursday 15 March 2012

The phenomenon of ‘chronic Lyme’; an observational study

Conclusion:  Our patients, who all attributed their symptoms to chronic Lyme disease, were heterogeneous. None had evidences of persistent Bb infection, but whether current diagnostic criteria are functional in patients with longstanding complaints is controversial. Other well‐defined illnesses or sequelae from earlier Lyme disease were probable as main explanatory factor in some cases. The patients were not more depressed, anxious, or hypochondriacal than the normal population, but they had poorer health‐related quality of life, more fatigue, and negative expectations about their illness. (Source: European Journal of Neurology)

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Thursday 15 March 2012

Tickborne Relapsing Fever in a Mother and Baby

Few people have likely heard of tickborne relapsing fever. Once they do, most will likely hope that they never get it. Tickborne relapsing fever, like Lyme disease, Rocky Mountain spotted fever, and ehrlichiosis, is a bacterial infection that is transmitted by a tick bite. Symptoms of tickborne relapsing fever can include one to four recurring episodes of three day intervals of fever (which can get up to 106.7°F by the end of the episode), joint aches, muscle pain, headache, and nausea. The affected person is then free of symptoms for up to seven days before they have another symptomatic episode or "crisis."...Read Full Post (Source: About.com Pediatrics)


Thursday 15 March 2012

The phenomenon of ‘chronic Lyme’; an observational study

Conclusion:  Our patients, who all attributed their symptoms to chronic Lyme disease, were heterogeneous. None had evidences of persistent Bb infection, but whether current diagnostic criteria are functional in patients with longstanding complaints is controversial. Other well‐defined illnesses or sequelae from earlier Lyme disease were probable as main explanatory factor in some cases. The patients were not more depressed, anxious, or hypochondriacal than the normal population, but they had poorer health‐related quality of life, more fatigue, and negative expectations about their illness. (Source: European Journal of Neurology)


Tuesday 13 March 2012

The amber theory of Lyme arthritis: initial description and clinical implications

Abstract  Lyme arthritis differs in many respects from other bacterial causes of arthritis. Based on an observation made for a patient with Lyme arthritis, we propose that the pathogenesis of joint swelling in Lyme arthritis is due to the introduction into the joint space of non-viable spirochetes or more likely spirochetal debris enmeshed in a host-derived fibrinous or collagenous matrix. This “amber” hypothesis can account for the clinical and laboratory features of Lyme arthritis and is amenable to experimental validation. Validation would directly impact the clinical management of patients with Lyme arthritis. Content Type Journal ArticleCategory Original ArticlePages 1-6DOI 10.1007/s10067-012-1964-xAuthors Gary P. Wormser, Division of Infectious Diseases of th...


Wednesday 7 March 2012

Viral Genetics Submits Pre-IND Document For Lyme Disease Drug Candidate To FDA

Viral Genetics announced recently that it has submitted a pre-IND briefing document to the US Food and Drug Administration (FDA) for its Lyme Disease drug candidate, VGV-L, marking important milestones for both the Company and its supporters in the Lyme community. (Source: Pharmaceutical Online News)


Wednesday 7 March 2012

Predicting The Spread Of Lyme Disease Carrying Ticks Across Canada

Researchers are watching as ticks that carry Lyme disease colonize Canada, but their research aims to predict the communities most likely to be hit by this sickness. "Our findings will help community groups and government agencies to alert the Canadians who may be at risk of picking up Lyme disease - those of us who like to visit the outdoors in spring and summer, when nymphal ticks are active but difficult to spot because of their size," said lead author Patrick Leighton of the University of Montreal's Faculty of Veterinary Medicine... (Source: Health News from Medical News Today)

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Tuesday 6 March 2012

Incidence and management of presumption of Lyme borreliosis in Belgium: recent data from the sentinel network of general practitioners

Abstract   An increasing incidence of tick bites and Lyme disease has been noticed internationally. The aims of this study are threefold: to estimate the incidence of tick bites and erythema migrans, to assess the compliance of the general practitioners (GPs) with the recommendations about the management of tick bites and erythema migrans, and finally, to have a look at the evolution over time, both on incidence and management. We used data of the Belgian network of sentinel general practitioners (SGP) to study the incidence rates in Belgium, the trend over time, and the degree of compliance of the SGP. The overall Belgian incidence rates in the SGP practice in 2008–2009 were 18.65 (95% CI 17.29–20.08) per 10,000 persons for tick bites and 9.02 (95% CI 8.08–10.03) for...


Tuesday 6 March 2012

Woman reverses Lyme disease with raw milk fasting

A woman reports that she has reversed Lyme disease by fasting with raw milk. This is not a suggestion for Lyme disease suffers, but a confirmation that raw milk from grass fed cows does have health-promoting properties. Most Lyme disease sufferers clamor for antibiotics... (Source: NaturalNews.com)


Tuesday 6 March 2012

Predicting the spread of ticks across Canada

Researchers are watching as ticks that carry Lyme disease colonize Canada, but their research aims to predict the communities most likely to be hit by this sickness. (Source: ScienceDaily Headlines)


Monday 5 March 2012

Testing for Lyme Disease: Follow the StepsTesting for Lyme Disease: Follow the Steps

When faced with a patient with potential Lyme disease, following the correct testing procedures will avoid false-negative and false-positive results. CDC Expert Commentary (Source: Medscape PublicHealth Headlines)


Monday 5 March 2012

Chronic Lyme Disease: It's Time To Solve The Medical Mystery Inside An Enigma [Narrative Matters]

Scientists and doctors disagree about whether there is such a condition as "chronic" Lyme disease or "post–Lyme disease syndrome." Americans need the National Institutes of Health and basic science research to help determine the answer. (Source: Health Affairs)

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Thursday 1 March 2012

High-throughput genotyping of advanced congenic lines by high resolution melting analysis for identification of Bbaa2, a QTL controlling Lyme arthritis.

Authors: Bramwell KK, Ma Y, Weis JH, Teuscher C, Weis JJ Abstract Congenic mapping is a powerful strategy to identify genomic loci regulating quantitative traits. Generating congenic lines is an iterative process of refinement that is both time and resource intensive. Here we report an alternative to traditional microsatellite marker analysis or costly high-density oligonucleotide single nucleotide polymorphism (SNP) arrays for congenic genotyping. The identification of inherited SNP variability in congenic lines using high resolution melting analysis (HRMA) represents a novel application of the method. The blocked probe HRMA approach offers a scalable, low cost, closed-tube system that benefits from rapid turnaround times, and unequivocal interpretation. The markedly higher preval...


Wednesday 29 February 2012

Iceman Was a Medical Mess

Five-thousand-three-hundred-year-old "Ötzi" was at risk for heart disease, carried Lyme disease (Source: ScienceNOW)


Tuesday 28 February 2012

High frequency of false positive IgM immunoblots for Borrelia burgdorferi in Clinical Practice

Clin Microbiol InfectAbstractAlthough it is known that two‐tier serologic testing for Lyme disease may be associated with false positive results on the IgM immunoblot, this problem has never been systematically studied in the clinical practice setting. In a retrospective investigation of patients referred to the private adult practice of an Infectious Diseases physician for possible for Lyme disease, 50 of 182 patients (27.5%, 95% CI: 21.1–34.6) were found to have a false positive IgM immunoblot. 78.0% of these patients had received unnecessary antibiotic therapy. False positive results were not restricted to any single commercial laboratory. Research on alternative testing strategies that eliminate the IgM immunoblot entirely is warranted. (Source: Clinical Microbiology and Infection)


Thursday 23 February 2012

Diagnosis of Borrelia‐associated uveitis in two horses

AbstractBorrelia burgdorferi, the etiologic agent of Lyme disease is a tick born spirochetal infection. Clinical signs of Lyme borreliosis are uncommon in horses, but when present they are often vague and nonspecific. In horses, Lyme borreliosis has been implicated in musculoskeletal, neurological, reproductive, and ocular disorders, including uveitis, but definitive diagnosis can be challenging as the causative agent is rarely isolated and serologic tests can be unreliable and do not confirm active disease. Here, we report two cases of equine uveitis associated with B. burgdorferi based on the identification of spirochetes within ocular fluids and confirmed with PCR testing. The two cases illustrate some of the challenges encountered in the recognition and diagnosis of equine Lyme borrel...


Thursday 23 February 2012

Long term antibiotic therapy may be an effective treatment for children co-morbid with Lyme disease and Autism Spectrum Disorder

In this study four male children (ages 26–55months) who have an ASD diagnosis and one male child (age 18months) who displayed behaviors consistent with an ASD, were assessed using the SCERTS Assessment Process Observation (SAP-O) form. The SAP-O meets state and federal requirements for providing a comprehensive, ongoing assessment of a child with an ASD . The SAP-O form measures children’s abilities using observational, authentic assessment procedures in the domains of joint attention, symbol use, mutual regulation, and self regulation via observations of specific behaviors in familiar settings . The five children tested positive for Lyme disease and their SAP-O score was evaluated before and after 6months of antibiotic therapy. Each child was prescribed 200mg of amoxicillin three time...

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Thursday 23 February 2012

Diagnosis of Borrelia‐associated uveitis in two horses

AbstractBorrelia burgdorferi, the etiologic agent of Lyme disease is a tick born spirochetal infection. Clinical signs of Lyme borreliosis are uncommon in horses, but when present they are often vague and nonspecific. In horses, Lyme borreliosis has been implicated in musculoskeletal, neurological, reproductive, and ocular disorders, including uveitis, but definitive diagnosis can be challenging as the causative agent is rarely isolated and serologic tests can be unreliable and do not confirm active disease. Here, we report two cases of equine uveitis associated with B. burgdorferi based on the identification of spirochetes within ocular fluids and confirmed with PCR testing. The two cases illustrate some of the challenges encountered in the recognition and diagnosis of equine Lyme borrel...


Wednesday 22 February 2012

Wild Birds as Sentinels for Multiple Zoonotic Pathogens Along an Urban to Rural Gradient in Greater Chicago, Illinois

SummaryWild birds are important in the maintenance and transmission of many zoonotic pathogens. With increasing urbanization and the resulting emergence of zoonotic diseases, it is critical to understand the relationships among birds, vectors, zoonotic pathogens, and the urban landscape. Here, we use wild birds as sentinels across a gradient of urbanization to understand the relative risk of diseases caused by three types of zoonotic pathogens: Salmonella pathogens, mosquito‐borne West Nile virus (WNV) and tick‐borne pathogens, including the agents of Lyme disease and human anaplasmosis. Wild birds were captured using mist nets at five sites throughout greater Chicago, Illinois, and blood, faecal and ectoparasite samples were collected for diagnostic testing. A total of 289 birds were ...


Wednesday 22 February 2012

A delicate interplay of structure, dynamics, and thermodynamics for function: a high pressure NMR study of outer surface protein a.

Authors: Kitahara R, Simorellis AK, Hata K, Maeno A, Yokoyama S, Koide S, Akasaka K Abstract Outer surface protein A (OspA) is a crucial protein in the infection of Borrelia burgdorferi causing Lyme disease. We studied conformational fluctuations of OspA with high-pressure (15)N/(1)H two-dimensional NMR along with high-pressure fluorescence spectroscopy. We found evidence within folded, native OspA for rapid local fluctuations of the polypeptide backbone in the nonglobular single layer β-sheet connecting the N- and C-terminal domains with τ < ms, which may give the two domains certain independence in mobility and thermodynamic stability. Furthermore, we found that folded, native OspA is in equilibrium (τ > ms) with a minor conformer I, which is almost fully disordered and...


Wednesday 22 February 2012

Wild Birds as Sentinels for Multiple Zoonotic Pathogens Along an Urban to Rural Gradient in Greater Chicago, Illinois

SummaryWild birds are important in the maintenance and transmission of many zoonotic pathogens. With increasing urbanization and the resulting emergence of zoonotic diseases, it is critical to understand the relationships among birds, vectors, zoonotic pathogens, and the urban landscape. Here, we use wild birds as sentinels across a gradient of urbanization to understand the relative risk of diseases caused by three types of zoonotic pathogens: Salmonella pathogens, mosquito‐borne West Nile virus (WNV) and tick‐borne pathogens, including the agents of Lyme disease and human anaplasmosis. Wild birds were captured using mist nets at five sites throughout greater Chicago, Illinois, and blood, faecal and ectoparasite samples were collected for diagnostic testing. A total of 289 birds were ...


Wednesday 22 February 2012

Doctors Warn About Booming Tick Population

BOSTON (CBS) – They’re here. The mild winter temperatures we’re enjoying mean the danger from ticks and Lyme disease has arrived early. Normally at this time of year cold weather causes ticks to go dormant, but not this winter. We went to a park in Needham Tuesday with entomologist Dr. Richard Pollack to see how easy it is to find the ticks. He dragged a small piece of fabric along the vegetation and after a couple of passes, there were deer ticks on the cloth. WBZ-TV’s Jonathan Elias reports var videoCanvas = new WNVideoWidget("WNVideoCanvas", "wnVideo_6768210");videoCanvas.SetWidth(320);videoCanvas.SetHeight(240);videoCanvas.SetVariable("clipId", "6768210");videoCanvas.SetReportingKeywords("CBS.BOSTON");videoCanvas.SetAdvertisingZone("CBS.BOSTON/worldnowplayer");v...

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Tuesday 21 February 2012

Lyme Neuroborreliosis Presenting as Alice in Wonderland Syndrome

We describe a 7-year-old boy with Alice in Wonderland syndrome associated with Lyme disease. He presented with metamorphopsia and auditory hallucinations in the absence of previous tick bites or other signs of Lyme disease. The boy never developed clinical seizures, and electroencephalograms during these spells indicated no epileptic activity. There was no history of migraine. Cranial magnetic resonance imaging produced normal results. Lyme serology tested positive in both serum and cerebrospinal fluid. He was treated with intravenous ceftriaxone for 3 weeks, with complete resolution of signs. This case report is the first, to our knowledge, of neuroborreliosis presenting as Alice in Wonderland syndrome with complete resolution of findings after intravenous antibiotic treatment. (Source: P...


Tuesday 21 February 2012

[Newsdesk] Research brief

Accurate information about the spatial pattern of risk of infection with Borrelia burgdorferi, the tick-borne bacterium that causes Lyme disease, is hard to obtain with human case reporting because of under-reporting and misdiagnosis. Now, researchers have constructed a Lyme disease risk map for the eastern USA by using standardised field sampling to estimate the density of B burgdorferi-infected host-seeking Ixodes scapularis (the Lyme disease vector) throughout the tick's range. Their map, which identifies infection risk foci in the northeast and upper midwest regions, should help to guide surveillance, control, and prevention efforts. (Source: The Lancet Infectious Diseases)


Tuesday 21 February 2012

The heterogeneous motility of the Lyme disease spirochete in gelatin mimics dissemination through tissue [Applied Physical Sciences]

The Lyme disease spirochete Borrelia burgdorferi exists in nature in an enzootic cycle that involves the arthropod vector Ixodes scapularis and mammalian reservoirs. To disseminate within and between these hosts, spirochetes must migrate through complex, polymeric environments such as the basement membrane of the tick midgut and the dermis of the mammal. To date, most research on the motility of B. burgdorferi has been done in media that do not resemble the tissue milieus that B. burgdorferi encounter in vivo. Here we show that the motility of Borrelia in gelatin matrices in vitro resembles the pathogen's movements in the chronically infected mouse dermis imaged by intravital microscopy. More specifically, B. burgdorferi motility in mouse dermis and gelatin is heterogeneous, with the bacte...



Monday 13 February 2012

Lyme meningitis, the major cause of childhood meningitis in an endemic area: a population based study

Conclusion LM was diagnosed in two-thirds of children with infectious meningitis in this LB endemic area. Distinct clinical characteristics distinguished the majority of children with LM from children with non-Lyme aseptic meningitis and bacterial meningitis. (Source: Archives of Disease in Childhood)

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Thursday 9 February 2012

0830 Help! I've become shorter than my wife: a treatable cause of camptocormia

Camptocormia is the abnormal posture of the trunk with thoraco-lumbar spine flexion, which increases during walking and improves when supine. A man, aged 57, noticed a rash behind his left knee. Next, he developed pain in his left knee and hip, then progressive leg weakness over 4–6 weeks. His posture started to stoop, to the point that he became shorter than his wife. Examination showed camptocormia. Muscle tone was normal, with mild weakness of the neck flexors, truncal and abdominal muscles, as well as in the left arm and leg. He was areflexic. He had a suspended sensory level from T8 to T10. Routine blood screen was normal, as was spinal MRI. LP showed: clear CSF, WBC 100 (66% neutrophils, 32% lymphocytes), protein 1884 mg/l, glucose 5.9 (serum 10.9), oligoclonal bands ...


Tuesday 7 February 2012

Lyme disease map pinpoints high-risk areas: Do you live in one?

Researchers from Yale School of Public Health collected ticks for three years to determine high-risk areas in order to bolster prevention (Source: Health News: CBSNews.com)


Tuesday 7 February 2012

New map pinpoints eastern U.S. Lyme disease risk areas

Researchers who spent three years dragging sheets of fabric through the woods to snag ticks have created a detailed map they claim could improve prevention, diagnosis and treatment of Lyme disease. (Source: CTV Health)


Monday 6 February 2012

Map Shows Where in U.S. to Beware of Lyme Disease

Title: Map Shows Where in U.S. to Beware of Lyme DiseaseCategory: Health NewsCreated: 2/3/2012 6:06:00 PMLast Editorial Review: 2/6/2012 (Source: MedicineNet Chronic Pain General)


Monday 6 February 2012

What Is Chronic Lyme Disease?

: What Is Chronic Lyme Disease? There are two camps when it comes to discussing chronic Lyme disease (Source: About.com Eating Disorders)


Monday 6 February 2012

Lyme Disease Presenting as Ptosis, Conjunctivitis, and Photophobia

(Source: Clinical Pediatrics)


Sunday 5 February 2012

Map Shows Where in U.S. to Beware of Lyme Disease

Northeast and parts of the Midwest are hotbeds of the tick-borne disease (Source: The Doctors Lounge - Infections)


Saturday 4 February 2012

Map pinpoints areas of Lyme disease

NEW HAVEN, Conn., Feb. 4 (UPI) -- A tick survey shows a risk of Lyme disease in the Northeast from Maine to Virginia, but most of the South free of Lyme disease-carrying ticks, researchers say. (Source: Health News - UPI.com)

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Saturday 4 February 2012

[Seminar] Lyme borreliosis

Lyme borreliosis (Lyme disease) is caused by spirochaetes of the Borrelia burgdorferi sensu lato species complex, which are transmitted by ticks. The most common clinical manifestation is erythema migrans, which eventually resolves, even without antibiotic treatment. However, the infecting pathogen can spread to other tissues and organs, causing more severe manifestations that can involve a patient's skin, nervous system, joints, or heart. The incidence of this disease is increasing in many countries. (Source: LANCET)


Friday 3 February 2012

Lyme Disease Ticks Endemic in Northeast, Northern MidwestLyme Disease Ticks Endemic in Northeast, Northern Midwest

Field researchers have generated a detailed map that they hope will guide appropriate diagnosis and more targeted treatment for patients suspected of having Lyme disease. Medscape Medical News (Source: Medscape Today Headlines)


Friday 3 February 2012

New map pinpoints Lyme disease risk areas

Researchers who spent three years dragging sheets of fabric through the woods to snag ticks have created a detailed map they claim could improve ... (Source: USATODAY.com Health)


Friday 3 February 2012

Areas Of Highest Human Risk For Lyme Disease In Eastern United States Detailed On New Map

A new map pinpoints well-defined areas of the Eastern United States where humans have the highest risk of contracting Lyme disease, one of the most rapidly emerging infectious diseases in North America, according to the U.S. Centers for Disease Control and Prevention. As part of the most extensive Lyme-related field study ever undertaken, researchers found high infection risk confined mainly to the Northeast, Mid-Atlantic and Upper Midwest and low risk in the South. The results were published in the February issue of the American Journal of Tropical Medicine and Hygiene... (Source: Health News from Medical News Today)

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Friday 3 February 2012

Atrial fibrillation, complete atrioventricular block and escape rhythm with bundle-branch block morphologies: An exceptional presentation of Lyme carditis

We report the case of a 51year old patient without significant past medical history admitted to the emergency department with complaints of generalized fatigue, shortness of breath and chest pain. He was a former endurance sport athlete and remains physically very active. On admission, the patient was afebrile with a blood pressure of 130/68mm Hg and a regular heart rate of 45bpm. Cardiovascular, pulmonary, and neurological examinations were normal; no skin lesion was observed. The initial ECG revealed atrial fibrillation, complete atrio-ventricular (AV) block and a wide QRS (140ms) escape rhythm of 45bpm with left or right bundle branch block morphology (). (Source: International Journal of Cardiology)


Thursday 2 February 2012

Ultrasonographic evaluation of knee joints in patients with Lyme disease

Conclusions: Ultrasonography may be useful in following the sequelae of Lyme disease. The abnormalities found in Lyme disease patients are non-specific and ultrasonography is not useful in the differential diagnosis. (Source: International Journal of Infectious Diseases)


Wednesday 1 February 2012

Tick Tally Reveals Lyme Disease Risk

Researchers counted more than 5,000 ticks to calculate the risk of Lyme disease in the Eastern U.S. Turns out the risk is high in the Northeast and nearly zero in the South.» E-Mail This     » Add to Del.icio.us (Source: NPR Health and Science)


Wednesday 1 February 2012

New Map Shows that Most Lyme-Infected Ticks Are in Northeast, Northern Midwest

Female blacklegged tick courtesy of Graham Hickling/University of Tennessee Lyme disease is notoriously tough to diagnose. The symptoms often don’t appear for one or two weeks after a bite and can vary from feeling flu-ish to longer-term neurological damage. And ticks seem to lie in wait throughout much of the U.S., prepared to pounce and infect a passerby. [More] (Source: Scientific American - Official RSS Feed)


Wednesday 1 February 2012

Post-treatment Lyme disease syndrome symptomatology and the impact on life functioning: is there something here?

Conclusions  Unlike clinical signs of Lyme disease, new-onset symptoms are reported by a subset of participants without evidence of depressive symptomatology. Patients who developed PTLDS had significantly lower life functioning compared to those without PTLDS. We propose future avenues for researching infection-triggered symptoms resulting from multiple mechanisms. Content Type Journal ArticlePages 1-10DOI 10.1007/s11136-012-0126-6Authors John N. Aucott, Department of Medicine, Johns Hopkins University School of Medicine, 10755 Falls Road, Suite 200, Lutherville, MD 21093, USAAlison W. Rebman, The Lyme Disease Research Foundation of Maryland, 10755 Falls Road, Suite 200, Lutherville, MD 21093, USALauren A. Crowder, The Lyme Disease Research Foundation of Maryland, 1...

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Wednesday 1 February 2012

Effect of surveillance method on reported characteristics of lyme disease, connecticut, 1996-2007.

Authors: Ertel SH, Nelson RS, Cartter ML Abstract To determine the effect of changing public health surveillance methods on the reported epidemiology of Lyme disease, we analyzed Connecticut data for 1996-2007. Data were stratified by 4 surveillance methods and compared. A total of 87,174 reports were received that included 79,896 potential cases. Variations based on surveillance methods were seen. Cases reported through physician-based surveillance were significantly more likely to be classified as confirmed; such case-patients were significantly more likely to have symptoms of erythema migrans only and to have illness onset during summer months. Case-patients reported through laboratory-based surveillance were significantly more likely to have late manifestations only and to be o...


Wednesday 1 February 2012

Human Risk of Infection with Borrelia burgdorferi, the Lyme Disease Agent, in Eastern United States.

Authors: Diuk-Wasser MA, Hoen AG, Cislo P, Brinkerhoff R, Hamer SA, Rowland M, Cortinas R, Vourc'h G, Melton F, Hickling GJ, Tsao JI, Bunikis J, Barbour AG, Kitron U, Piesman J, Fish D Abstract Abstract. The geographic pattern of human risk for infection with Borrelia burgdorferi sensu stricto, the tick-borne pathogen that causes Lyme disease, was mapped for the eastern United States. The map is based on standardized field sampling in 304 sites of the density of Ixodes scapularis host-seeking nymphs infected with B. burgdorferi, which is closely associated with human infection risk. Risk factors for the presence and density of infected nymphs were used to model a continuous 8 km×8 km resolution predictive surface of human risk, including confidence intervals for each pixel. Discon...


Wednesday 1 February 2012

New map pinpoints areas of highest human risk for lyme disease in eastern United States

(Burness Communications) A new map pinpoints well-defined areas of the Eastern United States where humans have the highest risk of contracting Lyme disease, one of the most rapidly emerging infectious diseases in North America, according to the US Centers for Disease Control and Prevention. (Source: EurekAlert! - Infectious and Emerging Diseases)


Wednesday 1 February 2012

Prevalence of antibodies to Borrelia burgdorferi sensu stricto in humans from a Cuban village.

CONCLUSION: These results support the previous serological findings, suggesting the presence of this borreliosis in Cuba. PMID: 22358362 [PubMed - in process] (Source: Braz J Infect Dis)


Friday 27 January 2012

Factors driving the abundance of Ixodes ricinus and the prevalence of zoonotic I. ricinus-borne pathogens in natural foci.

Authors: Ruiz-Fons F, Fernández-de-Mera IG, Acevedo P, Gortázar C, de la Fuente J Abstract Environmental factors may drive tick ecology and therefore tick-borne pathogen (TBP) epidemiology, which determines the risk of animals and humans of getting infected by TBPs. For this reason, the aim of this study was to analyze the influence of environmental factors on the abundance of immature stages of Ixodes ricinus and on the prevalence of two zoonotic I. ricinus-borne pathogens in endemic natural foci. I. ricinus abundance was measured in nine sites in northern Iberian Peninsula by dragging the vegetation with a cotton flannelette and ungulate abundance was measured by means of dung counts. In addition to ungulate abundance, variables related to spatial location, climate and soil wer...

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Wednesday 25 January 2012

Study Of Pet Dogs Shows Lyme Disease Risk In UK Bigger Than Previously Thought

The risk of a person living in the UK becoming infected with Lyme disease is much greater than previously thought, according to a study from Bristol University that surveyed pet dogs to find out how many of them harboured the ticks that transmit the disease. The researchers, from Bristol University, reported their findings earlier this month in the journal Comparative Immunology, Microbiology and Infectious Diseases... (Source: Health News from Medical News Today)


Wednesday 25 January 2012

Dogs 'higher Lyme disease risk'

Ticks that can transmit Lyme disease may be more prevalent in the UK than realised, say researchers who have found out how many pet dogs harbour them. (Source: BBC News | Health | UK Edition)


Wednesday 25 January 2012

Survey of pet dogs indicates Lyme disease risk much greater than previous estimates suggest

Ticks infected with the bacteria that cause Lyme disease may be considerably more prevalent in the UK than expected, according to new research from the University of Bristol that used pet dogs as ‘sentinels’ for human disease risk. (Source: University of Bristol news)


Tuesday 24 January 2012

CD14 cooperates with complement receptor 3 to mediate MyD88-independent phagocytosis of Borrelia burgdorferi [Immunology]

Phagocytosis of Borrelia burgdorferi, the causative agent of Lyme disease, is a poorly understood process, despite its importance during the host immune response to infection. B. burgdorferi has been shown to bind to different receptors on the surface of phagocytic cells, including the β2 integrin, complement receptor 3 (CR3). However, whether these receptors mediate the phagocytosis of the spirochete remains unknown. We now demonstrate that CR3 mediates the phagocytosis of the spirochete by murine macrophages and human monocytes. Interaction of B. burgdorferi with the integrin is not sufficient, however, to internalize the spirochete; phagocytosis requires the interaction of CR3 with the GPI-anchored protein, CD14, independently of TLR/MyD88-induced or inside-out signals. Interestingly, ...


Friday 20 January 2012

Spinal anaesthesia for caesarean delivery in a parturient with babesiosis and Lyme disease

We present a case of a parturient with babesiosis and Lyme disease who was scheduled for elective caesarean section. The caesarean section was performed under spinal anaesthesia, and the patient had a coronary artery dissection 4 days postoperatively. Neuraxial anaesthesia and possible mechanisms for the coronary artery dissection in a patient with babesiosis and Lyme disease are discussed. (Source: Anaesthesia)

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Friday 20 January 2012

Potential Infectious Etiology of Behçet's Disease.

Authors: Galeone M, Colucci R, D'Erme AM, Moretti S, Lotti T Abstract Behçet's disease is a multisystem inflammatory disorder characterized by recurrent oral aphthous ulcers, genital ulcers, uveitis, and skin lesions. The cause of Behçet's disease remains unknown, but epidemiologic findings suggest that an autoimmune process is triggered by an environmental agent in a genetically predisposed individual. An infectious agent could operate through molecular mimicry, and subsequently the disease could be perpetuated by an abnormal immune response to an autoantigen in the absence of ongoing infection. Potentia bacterial are Saccharomyces cerevisiae, mycobacteria, Borrelia burgdorferi, Helicobacter pylori, Escherichia coli, Staphylococcus aureus, and Mycoplasma fermentans, but the most...


Tuesday 17 January 2012

Predicted Outcomes of Vaccinating Wildlife to Reduce Human Risk of Lyme Disease

Vector-Borne and Zoonotic Diseases , Vol. 0, No. 0. (Source: Vector-Borne and Zoonotic Diseases)


Monday 16 January 2012

Estimating Lyme disease risk using pet dogs as sentinels.

Authors: Smith FD, Ballantyne R, Morgan ER, Wall R Abstract The reported number of cases of Lyme disease, Borrelia burgdorferi sensu lato, is thought to have increased in the UK over the past decade, but consistent surveillance data are lacking. Here the prevalence of B. burgdorferi in ticks attached to pet dogs was examined - using them as sentinels for human disease risk. Dogs give a good indication of the exposure of their human owners to infected ticks, since they largely share the same environment and visit the same outdoor areas. PCR was used to test 739 tick samples collected from 3534 dogs selected at random as they visited veterinary practices over a period of six months. Overall, the prevalence of infected ticks on all dogs was 0.5% giving an estimated 481 infected ticks ...


Friday 13 January 2012

The toll of TLR1 polymorphism in lyme disease: A tale of mice and men

(Source: Arthritis and Rheumatism)


Friday 13 January 2012

A Toll‐like receptor 1 polymorphism is associated with heightened T‐helper 1 inflammatory responses and antibiotic‐refractory lyme arthritis

Conclusion.The TLR1‐1805GG polymorphism in B. burgdorferi RST1‐infected patients was associated with stronger TH1‐like inflammatory responses, which may set the stage for antibiotic‐refractory arthritis. (Source: Arthritis and Rheumatism)

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Friday 13 January 2012

The toll of TLR1 polymorphism in lyme disease: A tale of mice and men

(Source: Arthritis and Rheumatism)


Thursday 12 January 2012

Lyme Disease as an Underlying Cause of Supraspinatus Tendinopathy in an Overhead Athlete.

DISCUSSION:/b>Many active patients spend time in the outdoors increasing their risk of exposure to a vector for Borrelia burgdorferi. Physical therapists spend a larger portion of time with patients than other health care professionals, and due to this extended contact and musculoskeletal knowledge are able to recognize atypical musculoskeletal disorders or musculoskeletal manifestations of unusual pathologies including Lyme disease. PMID: 22247404 [PubMed - as supplied by publisher] (Source: Physical Therapy)


Monday 9 January 2012

Of ticks, mice and men: understanding the dual-host lifestyle of Lyme disease spirochaetes

Authors: Justin D. Radolf, Melissa J. Caimano, Brian Stevenson & Linden T. Hu In little more than 30 years, Lyme disease, which is caused by the spirochaete Borrelia burgdorferi, has risen from relative obscurity to become a global public health problem and a prototype of an emerging infection. During this period, there has been an extraordinary accumulation (Source: Nature Reviews Microbiology)


Friday 6 January 2012

Cognitive decline can start at 45, research suggests

Brain deterioration starts earlier than previously thoughtRelated items from OnMedicaPublic warned to avoid tick bites and Lyme diseaseMulti-organisation launches new drive on dementiaNew tool "Sweet 16" reliably spots cognitive impairmentMRI can predict brain activity Vaccine linked to earlier onset of seizures in Dravet syndrome (Source: OnMedica Latest News)


Wednesday 4 January 2012

How can Lyme disease be prevented and controlled?

A new article assesses the potential reasons for the continued lack of success in prevention and control of Lyme disease and identifies areas where additional knowledge could be used to improve Lyme disease prevention and control strategies. (Source: ScienceDaily Headlines)

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Wednesday 4 January 2012

Absence of Lyme Disease Spirochetes in Larval Ixodes ricinus Ticks

Vector-Borne and Zoonotic Diseases Jan 2012, Vol. 12, No. 1: 21-27. (Source: Vector-Borne and Zoonotic Diseases)


Wednesday 4 January 2012

Genotypic Diversity of an Emergent Population of Borrelia burgdorferi at a Coastal Maine Island Recently Colonized by Ixodes scapularis

Vector-Borne and Zoonotic Diseases , Vol. 0, No. 0. (Source: Vector-Borne and Zoonotic Diseases)


Wednesday 4 January 2012

How can Lyme disease be prevented and controlled?

(Entomological Society of America) A new article appearing in the Journal of Medical Entomology assesses the potential reasons for the continued lack of success in prevention and control of Lyme disease and identifies areas where additional knowledge could be used to improve Lyme disease prevention and control strategies. (Source: EurekAlert! - Medicine and Health)


Sunday 1 January 2012

Toe dactylitis revealing late Lyme borreliosis

(Source: Arthritis and Rheumatism)


Sunday 1 January 2012

Lyme borreliosis: the challenge of accuracy.

Authors: Klempner MS, Halperin JJ, Baker PJ, Shapiro ED, O'Connell S, Fingerle V, Wormser GP Abstract No abstract available. PMID: 22271807 [PubMed - as supplied by publisher] (Source: The Netherlands Journal of Medicine)


Sunday 1 January 2012

A Toll‐like receptor 1 polymorphism is associated with heightened T‐helper 1 inflammatory responses and antibiotic‐refractory lyme arthritis

Conclusion.The TLR1‐1805GG polymorphism in B. burgdorferi RST1‐infected patients was associated with stronger TH1‐like inflammatory responses, which may set the stage for antibiotic‐refractory arthritis. (Source: Arthritis and Rheumatism)

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Friday 30 December 2011

Validation of a Clinical Prediction Rule to Distinguish Lyme Meningitis From Aseptic Meningitis

Available clinical prediction rules to identify children with cerebrospinal fluid pleocytosis at low risk for Lyme meningitis include headache duration, cranial nerve palsy, and percent cerebrospinal fluid mononuclear cells. These rules require independent validation. These clinical prediction rules accurately identify patients at low risk for Lyme meningitis in our large multicenter cohort. Children at low risk may be considered for outpatient management while awaiting Lyme serology. (Read the full article) (Source: PEDIATRICS)


Thursday 29 December 2011

Spatially explicit multi-criteria decision analysis for managing vector-borne diseases

We describe the conceptual framework that MCDA offers as well as technical considerations, approaches to implementation and expected outcomes. We conclude that MCDA is a powerful tool that offers tremendous potential for use in public health decision-making in general and vector-borne disease management in particular. (Source: International Journal of Health Geographics)

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Wednesday 28 December 2011

Ecology of Borrelia burgdorferi sensu lato in Europe: transmission dynamics in multi‐host systems, influence of molecular processes and effects of climate change

AbstractThe analysis of different multi‐host systems suggests that even hosts that are not capable of transmitting Borrelia burgdorferi sensu lato (s.l.) to the tick vector, Ixodes ricinus, or that are secondary reservoirs for these agents contribute to the intensity of transmission and to the overall risk of Lyme borreliosis, through the process of vector augmentation and pathogen amplification. On the other hand, above certain threshold densities, or in the presence of competition with primary reservoir hosts or low attachment rate of ticks to reservoir hosts, incompetent or less competent hosts may reduce transmission through dilution. The transmission of B. burgdorferi s.l. is affected by molecular processes at the tick‐host interface including mechanisms for the protection of spi...


Friday 23 December 2011

Cardiac MRI of Lyme disease myocarditis

A 41-year-old man presented with chest pain and recent flu-like illness. ECG demonstrated inferolateral ST elevation and troponin I level was raised. A diagnosis of myocardial infarction was made and intravenous thrombolysis was administered. Catheter angiography did not demonstrate significant coronary artery disease, so cardiac MRI was performed to clarify the diagnosis. Late gadolinium enhancement (LGE) images revealed multiple discreet band-like regions of enhancement in the mid-myocardial left ventricular wall with sparing of the subendocardial layer, suggestive of myocarditis rather than myocardial infarction (figure 1). Figure 1Cardiac MRI during the acute phase of the illness. The four-chamber late gadolinium enhancement (LGE) image (A) demonstrates mid-myocardial LGE in the left v...



Wednesday 21 December 2011

Lyme meningitis prediction rule validated

NEW YORK (Reuters Health) - A retrospective study confirms that the "Rule of 7's" tool can accurately identify children at low risk for Lyme meningitis. (Source: Modern Medicine)


Monday 19 December 2011

Isolated trochlear palsy secondary to Lyme neuroborreliosis

The objective of the study is to report the first case of isolated trochlear palsy secondary to Lyme neuroborreliosis in an adult. A 22-year-old male presented with history of flu-like illness and headache, accompanied by vertical binocular diplopia, worse on downgaze and better in upgaze and right head tilt. Physical examination revealed trochlear palsy on the left side with a compensatory head tilt to the opposite side. A subsequent workup for trochlear palsy was conducted, including hematological and cerebral spinal fluid serum studies, and magnetic resonance imaging of the brain. Immunoglobulin (Ig)M and IgG antibodies against Borrelia burgdorferi were positive in serum and cerebral spinal fluid (CSF). Symptoms of double vision completely resolved after 3 weeks of antibiotic ...

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Monday 19 December 2011

"Rule of 7s" Shows Accuracy in Lyme Meningitis Prediction"Rule of 7s" Shows Accuracy in Lyme Meningitis Prediction

The tool showed high reliability and simplicity in predicting a low risk for Lyme meningitis in children in a large multicenter cohort. Medscape Medical News (Source: Medscape Today Headlines)


Monday 19 December 2011

First Aid for Lyme Disease After a Tick Bite

They come out in the spring, and each year they spread further – the ticks. Thirty percent of them transmit borrelia pathogens, the causative agent of Lyme borreliosis that can damage joints and organs. The disease often goes undetected. In the future, a new type of gel is intended to prevent an infection – if applied after a tick bite. (Source: Disabled World)


Monday 19 December 2011

First aid after tick bites

They come out in the spring, and each year they spread further – the ticks. Thirty percent of them transmit borrelia pathogens, the causative agent of Lyme borreliosis that can damage joints and organs. The disease often goes undetected. In the future, a new type of gel is intended to prevent an infection – if applied after a tick bite. (Source: ScienceDaily Headlines)


Thursday 15 December 2011

Compounding for Lyme disease

Lyme disease may be the most rewarding compounding niche that most pharmacists have never considered. (Source: Drug Topics - Top News)

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Monday 12 December 2011

Ticks with bacteria that may cause Lyme disease found in N.S.

A community in southwestern Nova Scotia has been added to a list of places where ticks have been found to carry the bacteria that can cause Lyme disease. (Source: CTV Health)


Sunday 11 December 2011

The BB0646 protein demonstrates lipase and haemolytic activity associated with Borrelia burgdorferi, the aetiological agent of Lyme disease

SummaryThe etiological agent of Lyme disease, Borrelia burgdorferi, is transmitted by ticks of the Ixodes genus and, if untreated, can cause significant morbidity in affected individuals. Recent reports have shown that polyunsaturated fatty acids in the B. burgdorferi cell envelope are potential targets for oxidative damage, which can be lethal. How B. burgdorferi responds to this assault is not known. Herein we report evidence that bb0646 codes for a lipase that is located within the bosR operon and that has specificity for both saturated and polyunsaturated fatty acids. Specifically, strains harbouring mutated copies of the lipase, either in the form of an insertionally inactivated construct or site‐directed mutations within the active site, demonstrated attenuated lipolytic and ha...


Thursday 8 December 2011

Video: HealthPop: Blemish barriers, ticking timebomb, resting rumps

CBS News.com's Nick Dietz cracks the facts on facial scars' impact on job interviews; also, a record year for Lyme disease; and sitting around a lot gives you a big butt. (Source: Health News: CBSNews.com)

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Saturday 3 December 2011

Boom and Bust in Acorns Will Affect Many Creatures, Including Humans

A dearth this year of the familiar autumn seeds will probably lead to a steep drop in the population of field mice, and a particularly dangerous season for Lyme disease. (Source: NYT Health)


Thursday 1 December 2011

High Frequency of False Positive IgM Immunoblots for Borrelia burgdorferi in Clinical Practice

AbstractAlthough it is known that two‐tier serologic testing for Lyme disease may be associated with false positive results on the IgM immunoblot, this problem has never been systematically studied in the clinical practice setting. In a retrospective investigation of patients referred to the private adult practice of an Infectious Diseases physician for possible for Lyme disease, 50 of 182 patients (27.5%, 95% CI: 21.1‐34.6) were found to have a false positive IgM immunoblot. 78.0% of these patients had received unnecessary antibiotic therapy. False positive results were not restricted to any single commercial laboratory. Research on alternative testing strategies that eliminate the IgM immunoblot entirely is warranted. (Source: Clinical Microbiology and Infection)


Thursday 1 December 2011

Elimination of Borrelia burgdorferi and Anaplasma phagocytophilum in Rodent Reservoirs and Ixodes scapularis Ticks Using a Doxycycline Hyclate-Laden Bait.

Authors: Dolan MC, Schulze TL, Jordan RA, Dietrich G, Schulze CJ, Hojgaard A, Ullmann AJ, Sackal C, Zeidner NS, Piesman J Abstract Abstract. A field trial was conducted in a Lyme disease-endemic area of New Jersey to determine the efficacy of a doxycyline hyclate rodent bait to prophylactically protect and cure small-mammal reservoirs and reduce infection rates in questing Ixodes scapularis ticks for Borrelia burgdorferi and Anaplasma phagocytophilum. The doxycycline-laden bait was formulated at a concentration of 500 mg/kg and delivered during the immature tick feeding season in rodent-targeted bait boxes. The percentage of infected small mammals recovered from treated areas after 2 years of treatment was reduced by 86.9% for B. burgdorferi and 74% for A. phagocytophilum. Infectio...


Monday 21 November 2011

Clinical evidence for rapid transmission of Lyme disease following a tickbite

We describe 3 cases in which transmission of Borrelia burgdorferi, the spirochetal agent of Lyme disease, appears to have occurred in less than 24 h based on the degree of tick engorgement, clinical signs of acute infection, and immunologic evidence of acute Lyme disease. Health care providers and individuals exposed to ticks should be aware that transmission of Lyme disease may occur more rapidly than animal models suggest. A diagnosis of Lyme disease should not be ruled out based on a short tick attachment time in a subject with clinical evidence of B. burgdorferi infection. (Source: Diagnostic Microbiology and Infectious Disease)


Thursday 17 November 2011

Identification and characterization of Borrelia antigens as potential vaccine candidates against Lyme borreliosis.

Authors: Poljak A, Comstedt P, Hanner M, Schüler W, Meinke A, Wizel B, Lundberg U Abstract The three Borrelia species, Borrelia afzelii, Borrelia burgdorferi and Borrelia garinii are the main species causing the most common tick-borne zoonosis, Lyme borreliosis. By applying a genomic approach relying on human antibodies we have identified 122 antigenic Borrelia proteins associated with Lyme borreliosis, including already known and published protective antigens. The heterogeneity of the Borrelia species causing Lyme borreliosis makes the search for conserved antigens providing broad protection challenging. Using several in vitro assays we narrowed down the selection to 15 vaccine candidates. These antigens were further analyzed for antigenicity and cross-reactivity using sera from ...

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Monday 14 November 2011

Peripheral facial palsy in patients with tick‐borne encephalitis

AbstractAlthough tick‐borne encephalitis (TBE) has been recognized in Europe for more than 70 years and has been the topic of numerous reports, information on the involvement of facial nerve in the course of the disease is limited. Our study conducted at a single medical centre revealed that facial nerve involvement in the course of TBE in Central Europe is a) infrequent – it was found in only 11 of 1218 (0.9%) consecutive adult patients diagnosed with TBE; b) manifests with unilateral or rarely bilateral peripheral facial palsy (PFP) (9 and 2 patients, respectively); c) appears late in the course of acute illness – in our patients 10–20 days after the onset of the meningoencephalitic phase of TBE, and often after defervescence (in 8/11 patients; 6–13 days after normalisation of ...


Monday 14 November 2011

Pervasive Recombination and Sympatric Genome Diversification Driven by Frequency-Dependent Selection in Borrelia burgdorferi, the Lyme Disease Bacterium [Population and Evolutionary Genetics]

How genomic diversity within bacterial populations originates and is maintained in the presence of frequent recombination is a central problem in understanding bacterial evolution. Natural populations of Borrelia burgdorferi, the bacterial agent of Lyme disease, consist of diverse genomic groups co-infecting single individual vertebrate hosts and tick vectors. To understand mechanisms of sympatric genome differentiation in B. burgdorferi, we sequenced and compared 23 genomes representing major genomic groups in North America and Europe. Linkage analysis of >13,500 single-nucleotide polymorphisms revealed pervasive horizontal DNA exchanges. Although three times more frequent than point mutation, recombination is localized and weakly affects genome-wide linkage disequilibrium. We show by ...


Monday 14 November 2011

Evaluation of the preventive capacities of a topically applied azithromycin formulation against Lyme borreliosis in a murine model

Conclusions Our data indicate that topical treatment with a formulation containing azithromycin is a promising approach to prevent Lyme borreliosis shortly after a tick bite. (Source: Journal of Antimicrobial Chemotherapy)


Wednesday 9 November 2011

Prevalence of Borrelia Burgdorferi Infection in a Series of 98 Primary Cutaneous Lymphomas.

This study does not support a pathogenic role of B. burgdorferi in primary cutaneous B- and T-cell lymphomas from areas nonendemic for this microorganism and the consequent rationale for the adoption of antibiotic therapy in these patients. PMID: 22071292 [PubMed - as supplied by publisher] (Source: The Oncologist)


Wednesday 2 November 2011

Regulating the regulators: SOCS3 joins the dance

Invariant natural killer T (iNKT) cells belong to a prototypical regulatory T cell lineage that functions at the interface of innate immunity and adaptive immunity. Unlike peptide-restricted T cells, iNKT cells recognise and respond to various glycolipid antigens presented in the context of the major histocompatibility complex class I-like molecule CD1d.1 iNKT cells possess a number of unique effector functions, including the ability to rapidly secrete large quantities of Th1, Th2 and Th17 cytokines, and, as such, have had a number of regulatory functions assigned to them. Consequently, iNKT cells are able to regulate a large number of bystander cells that form part of the innate and adaptive immune systems, and iNKT cell biology has subsequently been linked to a broad range of diseases, i...

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Tuesday 1 November 2011

Patients Have a Right to Safe Surgery

Content Type Journal ArticleCategory EditorialPages 1-2DOI 10.1007/s00266-011-9836-3Authors Catherine B. Foss, International Society of Aesthetic Plastic Surgery, 45 Lyme Road, Suite 304, Hanover, NH 03755, USA Journal Aesthetic Plastic SurgeryOnline ISSN 1432-5241Print ISSN 0364-216X (Source: Aesthetic Plastic Surgery)


Tuesday 1 November 2011

Ecology of Borrelia burgdorferi sensu lato in Europe: transmission dynamics in multi‐host systems, influence of molecular processes and effects of climate change

AbstractThe analysis of different multi‐host systems suggests that even hosts that are not capable of transmitting Borrelia burgdorferi sensu lato (s.l.) to the tick vector, Ixodes ricinus, or that are secondary reservoirs for these agents contribute to the intensity of transmission and to the overall risk of Lyme borreliosis, through the process of vector augmentation and pathogen amplification. On the other hand, above certain threshold densities, or in the presence of competition with primary reservoir hosts or low attachment rate of ticks to reservoir hosts, incompetent or less competent hosts may reduce transmission through dilution. The transmission of B. burgdorferi s.l. is affected by molecular processes at the tick‐host interface including mechanisms for the protection of spi...

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Tuesday 1 November 2011

Ecology ofBorrelia burgdorferisensu lato in Europe: transmission dynamics in multi‐host systems, influence of molecular processes and effects of climate change.

AbstractThe analysis of different multi‐host systems suggests that even hosts that are not capable of transmitting Borrelia burgdorferi sensu lato (sl) to the tick vector, Ixodes ricinus, or that are secondary reservoirs for these agents contribute to the intensity of transmission and to the overall risk of Lyme borreliosis, through the process of vector augmentation and pathogen amplification. On the other hand, above certain threshold densities, or in the presence of competition with primary reservoir hosts or low attachment rate of ticks to reservoir hosts, incompetent or less competent hosts may reduce transmission through dilution. The transmission of B. burgdorferi sl is affected by molecular processes at the tick‐host interface including mechanisms for the protection of spiroche...


Tuesday 1 November 2011

Ceftriaxone-Induced Hemolysis in a Child With Lyme Arthritis: A Case for Antimicrobial Stewardship

We report here the case of a young girl treated with intravenous ceftriaxone who subsequently developed drug-induced autoimmune hemolytic anemia and renal failure. Her severe sequelae highlight the importance of antimicrobial stewardship. We review here the goals of antimicrobial stewardship and several strategies for achieving them. In addition, we briefly discuss the rare adverse drug event experienced by our patient. (Source: PEDIATRICS)


Tuesday 1 November 2011

Lyme disease and the heart in the UK.

Authors: Dubrey SW, Mehta PA, O Connell S Abstract Heart involvement from Lyme disease is uncommon in the UK but, when it does occur, can be rapidly progressive and require intensive therapy. A history of exposure and frequently a characteristic rash (erythema migrans) are the cardinal features in diagnosis. PMID: 22083002 [PubMed - in process] (Source: British Journal of Hospital Medicine)


Monday 31 October 2011

Antiphospholipid antibodies in patients with persistent lyme disease symptoms.

Authors: Stricker RB, Johnson L PMID: 22040690 [PubMed - as supplied by publisher] (Source: Lupus)


Monday 24 October 2011

Positive Borrelia burgdorferi serology secondary to intravenous immunoglobulin therapy

We describe a case where misleading positive Borrelia burgdorferi antibodies were caused by the administration of intravenous immunoglobulin. (Source: Journal of Infection)


Sunday 23 October 2011

Alessandra Luchini: nanoparticle traps detect diseases before our bodies do

A brilliant molecular-level test for signs of cancers developed by Alessandra Luchini promises far-reaching applicationsAlessandra Luchini is an engineer at George Mason University, Washington DC. Enabled by a grant from the Italian health service, she travelled to the US to study the molecular signs that some cancers release into the bloodstream. She was recently named in Popular Science's 'Brilliant 10' – an award for the achievements of scientists under 30.Why did you choose this line of research? We know that cancers have biomarkers that exist in the blood and body fluid in very low concentration, but they are volatile and degrade very quickly. So we were looking for something that current technology did not allow us to seek. We needed to figure out some kind of answer to that.Why di...


Saturday 22 October 2011

Presence of Borrelia burgdorferi“Sensu Lato” in patients with morphea from the Amazonic region in Brazil

Conclusion  Our data confirm the presence of borreliosis cases in the Amazon. (Source: International Journal of Dermatology)


Wednesday 19 October 2011

Coinfection with Rickettsia helvetica and Herpes Simplex Virus 2 in a Young Woman with Meningoencephalitis

Herpes virus type 2 DNA was detected by PCR in the cerebrospinal fluid in a young woman presenting with headache, stiff neck and pleocytosis, and serological findings consistent with reactivation. Since she was exposed to ticks, Lyme disease and tick-borne encephalitis were excluded. Further investigation in an ongoing project, using PCR and sequencing of the amplified products, showed the presence of Rickettsia helvetica in the cerebrospinal fluid. The bacteria were also isolated in Vero cell culture, and microimmunofluorescence confirmed the development of antibodies against Rickettsia spp. with predominance of IgM reactivity consistent with recent infection. She was treated with antibiotics and improved rapidly. The patient could easily have been judged to have isolated herpes meningiti...

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Monday 17 October 2011

Hepoxilins in cancer and inflammation—use of hepoxilin antagonists

Abstract  Cancer is often accompanied with inflammatory, thrombotic, and diabetic complications. Alternatively, chronic inflammation is believed to be a causative factor in several cancers. This review article brings together reported biological actions in these areas of the unstable naturally derived hepoxilins (HX), metabolites of arachidonic acid formed through the 12-LO pathway, and those of their synthetically derived stable HX antagonists (PBT; proprietary bioactive therapeutics). Although the HX pathway has been known for some three decades since its discovery by the author with much data originating from the author’s laboratory, studies by others over the past few years have confirmed early findings of the actions of HX as potent pro-inflammatory chemoattractant m...


Saturday 15 October 2011

European neuroborreliosis: neuropsychological findings 30 months post‐treatment

Conclusions:  As a group, LNB‐treated patients scored lower on four NP subtasks assessing processing speed, visual and verbal memory, and executive/attention functions, as compared to matched controls. The distribution of NP dysfunctions indicates that most LNB‐treated patients perform comparable to controls, whilst a small subgroup have a debilitating long‐term course with cognitive problems. (Source: European Journal of Neurology)


Friday 14 October 2011

Chronic Lyme Disease: The Controversies and the ScienceChronic Lyme Disease: The Controversies and the Science

Chronic lyme disease lacks an accepted clinical definition and objective evidence of the infection, yet patients are still seeking treatment. Expert Review of Anti-Infective Therapy (Source: Medscape Today Headlines)


Friday 14 October 2011

Carbon storage regulator A (CsrABb) is a repressor of Borrelia burgdorferi flagellin protein FlaB

In this report, we deciphered the regulatory role of CsrABb on FlaB synthesis and the mechanism involved by analyzing two mutants, csrABb‐ (a deletion mutant of csrABb) and csrABb+ (a mutant conditionally over‐expressing csrABb). We found that FlaB accumulation was significantly inhibited in csrABb+ but was substantially increased in csrABb‐. In contrast, the levels of other flagellar proteins remained unchanged. Cryo‐electron tomography and immuno‐fluorescence microscopic analyses revealed that the altered synthesis of CsrABb in these two mutants specifically affected flagellar filament length. The leader sequence of flaB transcript contains two conserved CsrA‐binding sites, with one of these sites overlapping the Shine‐Dalgarno sequence. We found that CsrABb bound to the fl...


Thursday 13 October 2011

Neuroborreliosis mimicking brachial amyotrophic diplegia

We describe a patient who presented with a “polio-like” syndrome with brachial diplegia caused by neuroborreliosis. (Source: Clinical Neurology and Neurosurgery)

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Saturday 1 October 2011

Epitope mapping of antibodies to VlsE protein of Borrelia burgdorferi in post-Lyme disease syndrome.

Authors: Chandra A, Latov N, Wormser GP, Marques AR, Alaedini A Abstract The VlsE lipoprotein of Borrelia burgdorferi elicits a strong immune response during the course of Lyme disease. The present study was aimed at characterization of the epitopes of VlsE targeted by the antibody response in patients with post-Lyme disease syndrome, a condition characterized by persisting symptoms of pain, fatigue, and/or neurocognitive impairment despite antibiotic treatment of B. burgdorferi infection. Epitope mapping was carried out using microarrays that contained synthesized overlapping peptides covering the full sequence of VlsE from B. burgdorferi B31. In addition to the previously characterized IR6 region in the variable domain, specific sequences in the N- and C-terminal invariable domai...


Saturday 1 October 2011

Peromyscus maniculatus , a Possible Reservoir Host of Borrelia garinii from the Gannet Islands Off Newfoundland and Labrador.

Peromyscus maniculatus , a Possible Reservoir Host of Borrelia garinii from the Gannet Islands Off Newfoundland and Labrador. J Parasitol. 2011 Oct;97(5):792-4 Authors: Baggs EM, Stack SH, Finney-Crawley JR, Simon NP Abstract abstract :  Thirty-five deer mice, Peromyscus maniculatus , were trapped on Gannet Cluster 2 (GC-2), one of a group of islands numbered by convention in the Gannet Island Archipelago, and examined for ectoparasites. One species each of Acari ( Ixodes uriae ) and Siphonaptera ( Orchopeas leucopus ) were recovered. Samples of mice favored males to females (3.4∶1). Twenty-nine percent (10) of the mice were free of ectoparasites. Males were more heavily parasitized than females when both parasites were considered. No ticks were recovered from the fema...


Saturday 1 October 2011

Lyme disease testing in children in an endemic area.

CONCLUSION: This study found that some clinicians in an LD-endemic area do not follow guidelines for diagnosing children suspected to have Lyme disease. PMID: 22164580 [PubMed - in process] (Source: WMJ)


Saturday 1 October 2011

Molecular characterization of the Borrelia burgdorferi in vivo-essential protein PncA.

Authors: Jewett MW, Jain S, Linowski AK, Sarkar A, Rosa PA Abstract The conversion of nicotinamide to nicotinic acid by nicotinamidase enzymes is a critical step in maintaining NAD(+) homeostasis and contributes to numerous important biological processes in diverse organisms. In Borrelia burgdorferi, the nicotinamidase enzyme, PncA, is required for spirochaete survival throughout the infectious cycle. Mammals lack nicotinamidases and therefore PncA may serve as a therapeutic target for Lyme disease. Contrary to the in vivo importance of PncA, the current annotation for the pncA ORF suggests that the encoded protein may be inactive due to the absence of an N-terminal aspartic acid residue that is a conserved member of the catalytic triad of characterized PncA proteins. Herein, we ha...


Saturday 1 October 2011

Humans Infected with Relapsing Fever Spirochete Borrelia miyamotoi, Russia.

We report 46 cases of B. miyamotoi infection in humans and compare the frequency and clinical manifestations of this infection with those caused by B. garinii and B. burgdorferi infection. All 46 patients lived in Russia and had influenza-like illness with fever as high as 39.5°C; relapsing febrile illness occurred in 5 (11%) and erythema migrans in 4 (9%). In Russia, the rate of B. miyamotoi infection in Ixodes persulcatus ticks was 1%-16%, similar to rates in I. ricinus ticks in western Europe and I. scapularis ticks in the United States. B. miyamotoi infection may cause relapsing fever and Lyme disease-like symptoms throughout the Holarctic region of the world because of the widespread prevalence of this pathogen in its ixodid tick vectors. PMID: 22000350 [PubMed - in process] (Sou...

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Saturday 1 October 2011

Infection Prevalences of Common Tick-borne Pathogens in Adult Lone Star Ticks (Amblyomma americanum) and American Dog Ticks (Dermacentor variabilis) in Kentucky.

Authors: Fritzen CM, Huang J, Westby K, Freye JD, Dunlap B, Yabsley MJ, Schardein M, Dunn JR, Jones TF, Moncayo AC Abstract Abstract. Rocky Mountain spotted fever, Lyme disease, and ehrlichiosis are tick-borne diseases that are reported annually in Kentucky. We conducted a survey to describe infection prevalence of tick-borne pathogens in Amblyomma americanum and Dermacentor variabilis ticks collected in Kentucky. During 2007-2008, we collected 287 ticks (179 D. variabilis and 108 A. americanum) from canine, feral hog, horse, raccoon, white-tailed deer, and human hosts in six counties in Kentucky. Ticks were screened for Rickettsia spp., Borrelia spp., and Ehrlichia spp. by using polymerase chain reaction. Forty-one (14.3%) ticks (31 A. americanum and 10 D. variabilis) were polymer...


Friday 30 September 2011

Evaluation of skin thickness lesions in patients with Lyme disease measured by modified Rodnan total skin score

Abstract  Recently, a possible etiological connection between infection with Borrelia burgdorferi and various skin lesions, including morphea and systemic sclerosis (SSc), has been discussed. The aim of our study was the evaluation of frequency of skin thickening typical of SSc or morphea in the group of patients with Lyme disease (LD) with frequent exposition to tick bites. The group consisted of 110 patients with LD frequently exposed to tick bites form the northeastern Poland, which is an endemic area for this disease. To measure the skin lesions, the modified Rodnan total skin score (RTSS) was used. In the analyzed group, no skin changes typical of morphea or skin thickening were found. According to RTSS, all patients scored 0 points. Raynaud’s phenomenon in all patien...


Friday 30 September 2011

Nervous System Lyme Disease: Is There a Controversy?

Semin Neurol 2011; 31: 317-324DOI: 10.1055/s-0031-1287652ABSTRACTInfection with the tick-borne spirochete, Borrelia burgdorferi, affects the nervous system in well-defined ways. Accurate diagnostic tools and effective therapeutic regimens are now well established. Persistent misconceptions about (1) the role and interpretation of laboratory tests, (2) what is and is not evidence of nervous system infection, and (3) what constitutes an expected response to treatment have fostered widespread perceptions that this disease is highly controversial. Infection causes the classically described triad of meningitis, radiculoneuritis, and cranial neuritis; however, virtually every known neurologic disorder has been blamed on this infection. For most (multiple sclerosis, amyotrophic lateral sclerosis,...


Thursday 29 September 2011

Host races in Ixodes ricinus, the European vector of Lyme borreliosis.

Authors: Kempf F, De Meeûs T, Vaumourin E, Noel V, Taragel'ová V, Plantard O, Heylen DJ, Eraud C, Chevillon C, McCoy KD Abstract Ixodes ricinus is a European tick that transmits numerous pathogenic agents, including the bacteria that cause Lyme disease (some genospecies of Borrelia burgdorferi sensu lato complex). This tick has been considered as a classic example of an extreme generalist vector. However, host-associations in such vector species are difficult to determine from field observations alone and recent work suggests that host specificity may be more frequent in ticks than previously thought. The presence of host-associated vector groups can significantly alter the circulation and evolutionary pathway of associated pathogens. In this paper, we explicitly test for host-as...


Sunday 25 September 2011

The job: Head of biodevelopment

Frank Milward has developed a number of vaccines, including one to control Lyme disease in dogs, and is working on several others (Source: FT.com - Drugs and Healthcare)

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Tuesday 20 September 2011

Retraction: Detection and differentiation of Borrelia burgdorferi sensu lato in ticks collected from sheep and cattle in China

This article [1] has been regretfully retracted due to plagiarism by the authors. The method for the identification of Borrelia burgdorferi sensu lato species in ticks presented in the article was originally developed and published by Sjoerd Rijpkema and colleagues [2]. The authors apologise to all affected parties for the inconvenience caused.References1. Niu Q, Guan G, Yang J, Fu Y, Xu Z, Li Y, Miling Ma1, Liu Z, Liu J, Liu A, Ren Q, Jorgensen W, Luo J, Yin H: Detection and differentiation of Borrelia burgdorferi sensu lato in ticks collected from sheep and cattle in China. BMC Veterinary Research 2011, 7:172. Rijpkema SG, Molkenboer MJ, Schouls LM, Jongejan F, Schellekens JF: Simultaneous Detection and Genotyping of Three Genomic Groups of Borrelia burgdorferi Sensu Lato in Dutch Ixodes...


Tuesday 20 September 2011

Anaplasmataceae and Borrelia burgdorferi sensu lato in the sand lizard Lacerta agilis and co-infection of these bacteria in hosted Ixodes ricinus ticks

In this paper we show the role of sand lizard (Lacerta agilis) in the transmission cycle of important tick-borne pathogens, Anaplasmataceae and Borrelia burgdorferi s.l. Moreover, we found a significant correlation between numbers of ticks infected with Anaplasmataceae and with B. burgdorferi s.l. living on the same lizard. Image: Ticks (Ixodes ricinus) feeding on a sand lizard. (Source: Parasites and Vectors)


Monday 19 September 2011

New Tick-Borne Disease, Distantly Related to Lyme, Is Found

The disease is caused by a spirochete bacterium called Borrelia miyamotoi, which is distantly related to Borrelia burgdorferi, the spirochete that causes Lyme disease. (Source: NYT Health)


Friday 16 September 2011

Absence of Lyme Disease Spirochetes in Larval Ixodes ricinus Ticks

Vector-Borne and Zoonotic Diseases , Vol. 0, No. 0. (Source: Vector-Borne and Zoonotic Diseases)


Friday 16 September 2011

When Ticks Transmit Dangerous Pathogens Local Antibiotic Therapy Stops Lyme Disease

Blood-sucking ticks are not just a nuisance, they can also transmit dangerous diseases. One of them is Lyme disease, which is caused by bacteria of the genus Borrelia, and requires a course of treatment with antibiotics lasting several weeks. LMU researchers have come up with a quicker alternative. Lyme disease is a dangerous disease which is transmitted by ticks. Blood-sucking ticks ingest the agents that cause the disease bacteria of the species Borrelia burgdorferi and its relatives during a blood meal, and subsequently transmit them to the next victim they feast on, often a person... (Source: Health News from Medical News Today)

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Friday 16 September 2011

Lyme disease-associated glomerulonephritis

We report two cases of Lyme disease-associated glomerulonephritis. A 57-year-old female presented with rash, volume overload, hypertension and rapidly progressive glomerulonephritis. Biopsy confirmed an immune complex-mediated, membranoproliferative lesion. She was treated successfully with steroids and antibiotics. In a second case, a 40-year-old male, with a previously known microscopic hematuria, presented with rash, arthralgias, new proteinuria and gross hematuria following a tick bite. Biopsy revealed focal proliferative IgA nephropathy. Treatment with steroids and antibiotics resulted in rapid resolution of findings. Acute Lyme disease may contribute to the development of de novo, or activation of previously quiescent, immune-mediated glomerular disease. (Source: Nephrology Dialysis ...


Friday 16 September 2011

The coenzyme A disulphide reductase of Borrelia burgdorferi is important for rapid growth throughout the enzootic cycle and essential for infection of the mammalian host

SummaryIn a microarray analysis of the RpoS regulon in mammalian host‐adapted Borrelia burgdorferi, bb0728 (cdr) was found to be dually transcribed by the sigma factors σ70 and RpoS. The cdr gene encodes a coenzyme A disulphide reductase (CoADR) that reduces CoA‐disulphides to CoA in an NADH‐dependent manner. Based on the abundance of CoA in B. burgdorferi and the biochemistry of the enzyme, CoADR has been proposed to play a role in the spirochaete's response to reactive oxygen species. To better understand the physiologic function(s) of BbCoADR, we generated a B. burgdorferi mutant in which the cdr gene was disrupted. RT‐PCR and 5′‐RACE analysis revealed that cdr and bb0729 are co‐transcribed from a single transcriptional start site upstream of the bb0729 coding sequenc...


Thursday 15 September 2011

Seabirds and the Circulation of Lyme Borreliosis Bacteria in the North Pacific

Vector-Borne and Zoonotic Diseases , Vol. 0, No. 0. (Source: Vector-Borne and Zoonotic Diseases)


Thursday 15 September 2011

Prevalence of Anaplasma phagocytophilum and Coinfection with Borrelia burgdorferi Sensu Lato in the Hard Tick Ixodes ricinus in the City of Hanover (Germany)

Vector-Borne and Zoonotic Diseases , Vol. 0, No. 0. (Source: Vector-Borne and Zoonotic Diseases)


Thursday 15 September 2011

When ticks transmit dangerous pathogens

(Ludwig-Maximilians-Universität München) Blood-sucking ticks are not just a nuisance, they can also transmit dangerous diseases. One of them is Lyme disease, which is caused by bacteria of the genus Borrelia, and requires a course of treatment with antibiotics lasting several weeks. LMU researchers have come up with a quicker alternative. (Source: EurekAlert! - Medicine and Health)

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Wednesday 14 September 2011

Reservoir Targeted Vaccine for Lyme Borreliosis Induces a Year Long, Neutralizing Antibody Response to OspA in White-footed Mice.

Authors: Meirelles Richer L, Aroso M, Contente-Cuomo T, Ivanova L, Gomes-Solecki M Abstract Lyme disease is caused by the spirochete Borrelia burgdorferi. The enzootic cycle of this pathogen requires that Ixodes spp. acquire B. burgdorferi from infected wildlife reservoirs and transmit it to other uninfected wildlife. At present, there are no effective measures to control B. burgdorferi; there is no human vaccine available, and existing vector control measures are generally not acceptable to the public. However, if B. burgdorferi could be eliminated from its reservoir hosts or from the ticks that feed on them, the enzootic cycle would be broken, and the incidence of Lyme disease would decrease. We developed a reservoir targeted bait vaccine (RTV) based on the immunogenic outer surf...


Thursday 8 September 2011

Chronic pain: Watch out before accepting diagnosis and treatment

Experts argue that patients should be diligent in demanding proof of safety and benefit before beginning chronic pain treatment, as some medications have little evidence that they alleviate conditions for which they are prescribed. The experts dispel myths surrounding chronic Lyme disease, using it as an example of why patients ensure that diagnostic and treatment tools are approved by the FDA and not just recommended by other patients and physicians. (Source: ScienceDaily Headlines)


Tuesday 6 September 2011

Cerebrospinal fluid findings in adults with acute Lyme neuroborreliosis

The objective of the study was to investigate the CSF changes during acute LNB. Routine CSF parameters [leukocyte count, protein, lactate and albumin concentrations, CSF/serum quotients of albumin (QAlb), IgG, IgA and IgM, and oligoclonal IgG bands] and the Borrelia burgdorferi (BB)-specific antibody index were retrospectively studied in relation to the clinical presentation in patients diagnosed with acute LNB. A total of 118 patients with LNB were categorized into the following groups according to their symptoms at presentation; group 1: polyradiculoneuritis (Bannwarth’s syndrome), group 2: isolated facial palsy and group 3: predominantly meningitic course of the disease. In addition to the CSF of patients with acute LNB, CSF of 19 patients with viral meningitis (VM) and 3 with n...


Thursday 1 September 2011

Orbital Inflammation and Lyme Disease

Sclerosing orbital inflammation is a poorly understood entity that frequently results in visual morbidity. Herein, we report a case of sclerosing orbital inflammation manifesting as dacryoadenitis with bony erosion associated with Lyme disease. (Source: Ophthalmology)


Thursday 1 September 2011

Canine serology as adjunct to human lyme disease surveillance.

Authors: Mead P, Goel R, Kugeler K Abstract To better define areas of human Lyme disease risk, we compared US surveillance data with published data on the seroprevalence of Borrelia burgdorferi antibodies among domestic dogs. Canine seroprevalence >5% was a sensitive but nonspecific marker of human risk, whereas seroprevalence <1% was associated with minimal risk for human infection. PMID: 21888800 [PubMed - in process] (Source: Emerging Infectious Diseases)

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Thursday 1 September 2011

Differential Risk for Lyme Disease along Hiking Trail, Germany.

Authors: Richter D, Matuschka FR Abstract To estimate relative risk for exposure to ticks infected with Lyme disease-causing spirochetes in different land-use types along a trail in Germany, we compared tick density and spirochete prevalence on ruminant pasture with that on meadow and fallow land. Risk was significantly lower on pasture than on meadow and fallow land. PMID: 21888798 [PubMed - in process] (Source: Emerging Infectious Diseases)


Wednesday 31 August 2011

Serum CXCL13 Chemokine is Not a Marker for Active Lyme Borreliosis.

Authors: Wutte N, Berghold A, Krainberger I, Aberer E PMID: 21879246 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)


Saturday 27 August 2011

[Personal View] Antiscience and ethical concerns associated with advocacy of Lyme disease

SummaryAdvocacy for Lyme disease has become an increasingly important part of an antiscience movement that denies both the viral cause of AIDS and the benefits of vaccines and that supports unproven (sometimes dangerous) alternative medical treatments. Some activists portray Lyme disease, a geographically limited tick-borne infection, as a disease that is insidious, ubiquitous, difficult to diagnose, and almost incurable; they also propose that the disease causes mainly non-specific symptoms that can be treated only with long-term antibiotics and other unorthodox and unvalidated treatments. (Source: The Lancet Infectious Diseases)


Friday 26 August 2011

Acute life threatening cerebellitis presenting with no apparent cerebellar signs

Acute cerebellitis is an inflammatory syndrome which can occur as either a primary infectious, para or post infectious disorder. Infectious pathogens that have been reported to be causal or associated with acute cerebellitis include varicella, measles, mumps, rubella, Epstein-Barr virus, cytomegalovirus, herpes simplex virus, influenza virus, parainfluenza virus, poliovirus, coxsackie virus, salmonella typhi, Borrelia burgdorferi, Coxiela burnetii, bordetella pertussis and mycoplasma pneumoniae . The incidence of acute cerebellitis is unknown and the literature has consisted primarily of a collection of case reports. Acute cerebellitis may also occur without evidence of preceding or concurrent infection . (Source: Clinical Neurology and Neurosurgery)


Thursday 25 August 2011

Agents of Human Anaplasmosis and Lyme Disease at Camp Ripley, Minnesota

Vector-Borne and Zoonotic Diseases , Vol. 0, No. 0. (Source: Vector-Borne and Zoonotic Diseases)

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Thursday 25 August 2011

Late calcification of the mitral–aortic junction causing transient complete atrio-ventricular block after mediastinal radiation of Hodgkin lymphoma: Multimodal visualization

Complete atrio-ventricular (AV) block etiology may be either functional (autonomic, metabolic/endocrine disease or drug-related), which tends to be reversible, or structural, characterized by fibrosis of myocardial conduction tissue and often related to acute and chronic coronary artery disease, infectious disease (Lyme, Chagas disease), congenital heart disease, inflammatory disease (systemic lupus erythematosus, rheumatoid arthritis), infiltrative disease (amyloidosis, sarcoidosis, hemochromatosis), cancer (lymphoma, mesothelioma, melanoma), and radiation therapy . Complete AV block after radiation therapy is reported to usually occur within 2–7years following radiation treatment . (Source: International Journal of Cardiology)


Wednesday 24 August 2011

Why Our Thoughts Keep Us Lost

Two weeks after I move to Westchester, I meet a suburban mom who tells me about an amazing meditation teacher in town I just have to meet.read more (Source: Psychology Today Depression Center)


Wednesday 24 August 2011

Widespread dispersal of Borrelia burgdorferi-infected ticks collected from songbirds across Canada.

We report transstadial transmission (larva to nymph) of B. burgdorferi in I. auritulus. Data suggest a possible 4-tick, i.e., I. angustus, I. auritulus, I. pacificus, and I. spinipalpis enzootic cycle of B. burgdorferi on Vancouver Island, British Columbia. Our results suggest that songbirds infested with B. burgdorferi-infected ticks have the potential to start new tick populations endemic for Lyme disease. Because songbirds disperse B. burgdorferi-infected ticks outside their anticipated range, health-care providers are advised that people can contract Lyme disease locally without any history of travel. PMID: 21864130 [PubMed - as supplied by publisher] (Source: The Journal of Parasitology)


Monday 22 August 2011

Asymptomatic Macrothrombocytopenia in a Young Pure-Bred Beagle Dog: A Case Report.

Authors: Bodié K, Gagne GD, Sramek MK, Desmond DJ, Abel SJ, Fagerland JA Abstract During baseline evaluation prior to a preclinical safety study, a 10-month-old male pure-bred Beagle dog was found to have marked thrombocytopenia (6 × 103 platelets [PLT]/µL) associated with a mean platelet volume (MPV) of 17.9 fL. Tests for Rickettsia rickettsii, Ehrlichia canis, and Borrelia burgdorferi were negative. Buccal bleeding time was normal. Over 3 months, PLT were 4 to 141 × 103 PLT/µL, and MPV was 11.4 to 25.1 fL; however, PLT were <50 × 103 PLT/µL and MPV was >16 fL during most of this period. Antinuclear antibody (ANA) and anti-PLT antibody tests were negative. Genotyping for the presence of a beta 1-tubulin mutation demonstrated the normal wild-type gene. Treatment with p...


Saturday 20 August 2011

Following a Tick Bite: Double Infections by Tick‐Borne Encephalitis Virus and the Spirochete Borrelia and Other Potential Multiple Infections

SummaryIn Central Europe and large parts of Asia, tick‐borne‐encephalitis (TBE) and Lyme borreliosis caused by the spirochetal bacterium of the genus Borrelia are among the most common diseases transmitted by the bite of a tick. When in regions with overlapping TBE virus and Borrelia endemicity, a tick bite causes the victim to become ill, it is important that appropriate serological and other laboratory investigations form part of the differential diagnosis. Account must always be taken of the fact that a tick bite may be followed by a double infection with the TBE virus and Borrelia. For this reason, a comprehensive diagnostic work‐up aimed at detecting co‐infection by both pathogens, even when the tick bite occurs in an endemic region for both pathogens but the initial clinical ...

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Friday 19 August 2011

Abnormal corneal nerves in a patient with Lyme disease

Authors: X Ricaud, J-P Rozenbaum, S Landowski, C Baudouin & A Labbé (Source: Eye)


Friday 19 August 2011

Bioluminescent imaging of Borrelia burgdorferi in vivo demonstrates that the fibronectin binding protein BBK32 is required for optimal infectivity

SummaryThe etiologic agent of Lyme disease, Borrelia burgdorferi, is transmitted via infected Ixodes spp. ticks. Infection, if untreated, results in dissemination to multiple tissues and significant morbidity. Recent developments in bioluminescence technology allow in vivo imaging and quantification of pathogenic organisms during infection. Herein, luciferase‐expressing B. burgdorferi and strains lacking the decorin adhesins DbpA and DbpB, as well as the fibronectin adhesin BBK32, were quantified by bioluminescent imaging to further evaluate their pathogenic potential in infected mice. Quantification of bacterial load was verified by quantitative PCR (qPCR) and cultivation. B. burgdorferi lacking DbpA and DbpB were only seen at the 1 h time point post‐infection, consistent with its low...


Friday 19 August 2011

Bioluminescent imaging of Borrelia burgdorferi in vivo demonstrates that the fibronectin‐binding protein BBK32 is required for optimal infectivity

SummaryThe aetiological agent of Lyme disease, Borrelia burgdorferi, is transmitted via infected Ixodes spp. ticks. Infection, if untreated, results in dissemination to multiple tissues and significant morbidity. Recent developments in bioluminescence technology allow in vivo imaging and quantification of pathogenic organisms during infection. Herein, luciferase‐expressing B. burgdorferi and strains lacking the decorin adhesins DbpA and DbpB, as well as the fibronectin adhesin BBK32, were quantified by bioluminescent imaging to further evaluate their pathogenic potential in infected mice. Quantification of bacterial load was verified by quantitative PCR (qPCR) and cultivation. B. burgdorferi lacking DbpA and DbpB were only seen at the 1 h time point post infection, consistent with ...


Thursday 18 August 2011

Following a Tick Bite: Double Infections by Tick‐Borne Encephalitis Virus and the Spirochete Borrelia and Other Potential Multiple Infections

SummaryIn Central Europe and large parts of Asia, tick‐borne‐encephalitis (TBE) and Lyme borreliosis caused by the spirochetal bacterium of the genus Borrelia are among the most common diseases transmitted by the bite of a tick. When in regions with overlapping TBE virus and Borrelia endemicity, a tick bite causes the victim to become ill, it is important that appropriate serological and other laboratory investigations form part of the differential diagnosis. Account must always be taken of the fact that a tick bite may be followed by a double infection with the TBE virus and Borrelia. For this reason, a comprehensive diagnostic work‐up aimed at detecting co‐infection by both pathogens, even when the tick bite occurs in an endemic region for both pathogens but the initial clinical ...


Thursday 18 August 2011

A tick mannose-binding lectin inhibitor interferes with the vertebrate complement cascade to enhance transmission of the lyme disease agent.

Authors: Schuijt TJ, Coumou J, Narasimhan S, Dai J, Deponte K, Wouters D, Brouwer M, Oei A, Roelofs JJ, van Dam AP, van der Poll T, Van't Veer C, Hovius JW, Fikrig E Abstract The Lyme disease agent Borrelia burgdorferi is primarily transmitted to vertebrates by Ixodes ticks. The classical and alternative complement pathways are important in Borrelia eradication by the vertebrate host. We recently identified a tick salivary protein, designated P8, which reduced complement-mediated killing of Borrelia. We now discover that P8 interferes with the human lectin complement cascade, resulting in impaired neutrophil phagocytosis and chemotaxis and diminished Borrelia lysis. Therefore, P8 was renamed the tick salivary lectin pathway inhibitor (TSLPI). TSLPI-silenced ticks, or ticks exposed ...

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Thursday 18 August 2011

Tick salivary proteins offer the lyme disease spirochetes an easy ride and another way to hide.

Authors: Marconi RT, McDowell JV Abstract The ability of the Lyme disease spirochetes to establish an infection in mammals is dependent in part on proteins of tick origin. Schuijt et al. (2011) investigate the role of the tick-derived protein, TSLPI, in spirochete transmission and in the evasion of killing by the lectin complement pathway. PMID: 21843866 [PubMed - in process] (Source: Cell Host and Microbe)


Wednesday 17 August 2011

BORRELIA REMEDY (Borrelia Burgdorferi,) Liquid [Apotheca Company]

Updated Date: Aug 17, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))


Monday 15 August 2011

Quantitation of cell-associated borrelial DNA in the blood of Lyme disease patients with erythema migrans

This study was designed to measure the level of Borrelia burgdorferi in the plasma of Lyme disease patients and correlate these levels with selected clinical and laboratory findings. Nested and quantitative polymerase chain reaction (qPCR) was employed to detect cell-associated flaB gene DNA in the plasma of untreated early Lyme disease patients with erythema migrans (EM). Twenty-nine (45.3%) of 64 patients had evidence of B. burgdorferi in their plasma by at least one of the PCR methods. For the 22 qPCR-positive patients, the mean number of flaB gene copies per mL of plasma was 4,660, with a range of 414 to 56,000. The number of flaB gene copies did not significantly correlate with any of the clinical, demographic, or laboratory variables assessed. For reasons discussed, we suggest ca...


Saturday 13 August 2011

Presence of Borrelia burgdorferi sensu lato antibodies in the serum of patients with abdominal aortic aneurysms

Abstract  Infectious agents are likely to play a role in the pathogenesis of chronic inflammatory diseases, including abdominal aortic aneurysms (AAAs). The goal of this study was to determine if Borrelia burgdorferi sensu lato (sl), a microorganism responsible for Lyme disease, is involved in the etiology of AAAs. The presence of serum antibodies against B. burgdorferi sl was measured with enzyme-linked immunosorbent assay (ELISA) and confirmed by Western blotting in 96 AAA and 108 peripheral artery disease (PAD) patients. Polymerase chain reaction (PCR) was used for the detection of Borrelia-specific DNA in the aneurysm wall. Among AAA patients 34% and among PAD patients 16% were seropositive for B. burgdorferi sl antibodies (Fisher’s exact test, p = 0.003; odds ratio ...


Saturday 13 August 2011

NMR structure of an acyl-carrier protein from Borrelia burgdorferi

Nearly complete resonance assignment and the high-resolution NMR structure of the acyl-carrier protein from Borrelia burgdorferi, a target of the Seattle Structural Genomics Center for Infectious Disease (SSGCID) structure-determination pipeline, are reported. This protein was chosen as a potential target for drug-discovery efforts because of its involvement in fatty-acid biosynthesis, an essential metabolic pathway, in bacteria. It was possible to assign >98% of backbone resonances and >92% of side-chain resonances using multidimensional NMR spectroscopy. The NMR structure was determined to a backbone r.m.s.d. of 0.4 Å and contained four α-helices and two 310-helices. A structure-homology search revealed that this protein is highly similar to the acyl-carrier protein from Aquifex aeol...

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Thursday 11 August 2011

Lyme borreliosis in Europe.

Authors: Rizzoli A, Hauffe H, Carpi G, Vourc H G, Neteler M, Rosa R PMID: 21794218 [PubMed - in process] (Source: Euro Surveill)


Thursday 11 August 2011

The Jurassic coastline of Lyme Regis – in pictures

Guardian photographer Graeme Robertson travels to Lyme Regis in Dorset to photograph the Jurassic coastGraeme Robertson (Source: Guardian Unlimited Science)


Thursday 11 August 2011

Tracking Lyme Disease in Dogs May Help Protect Humans

Title: Tracking Lyme Disease in Dogs May Help Protect HumansCategory: Health NewsCreated: 8/10/2011 2:06:00 PMLast Editorial Review: 8/11/2011 (Source: MedicineNet Arthritis General)


Wednesday 10 August 2011

Canine Serology as Adjunct to Human Lyme Disease Surveillance, P. Mead et al.

(Source: Emerging Infectious Diseases Journal)


Wednesday 10 August 2011

Differential Risk for Lyme Disease along Hiking Trail, Germany, D. Richter and F.-R. Matuschka

(Source: Emerging Infectious Diseases Journal)

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Wednesday 10 August 2011

Canine Serology as Adjunct to Human Lyme Disease Surveillance, P. Mead et al.

(Source: Emerging Infectious Diseases Journal)


Wednesday 10 August 2011

Differential Risk for Lyme Disease along Hiking Trail, Germany, D. Richter and F.-R. Matuschka

(Source: Emerging Infectious Diseases Journal)


Wednesday 10 August 2011

Tracking Lyme Disease in Dogs May Help Protect Humans

Canine blood tests can indicate high-risk areas for people, CDC researchers say Source: HealthDay Related MedlinePlus Page: Lyme Disease (Source: MedlinePlus Health News)



Tuesday 9 August 2011

Spatial distribution of seroprevalence for Anaplasma phagocytophilum, Borrelia burgdorferi, Ehrlichia canis, and Dirofilaria immitis in dogs in Washington, Oregon, and California

Conclusions: Seropositivity for vector‐borne pathogens is broadly but patchily distributed in dogs in CA, OR, and WA. (Source: Veterinary Clinical Pathology)


Sunday 7 August 2011

Lyme Disease Research - More Aggressive Treatments

Lyme Disease Research, Legislation Allows More Aggressive Treatments for Sufferers. (Source: Disabled World)


Friday 5 August 2011

Antibodies Linked to Long-Term Lyme Disease Symptoms

By Amy Maxmen of Nature magazine Some patients with Lyme disease still show symptoms long after their treatment has finished. [More] (Source: Scientific American - Official RSS Feed)


Friday 5 August 2011

Identification of membrane associated drug targets in Borrelia burgdorferi ZS7- subtractive genomics approach.

In this study, 272 essential proteins were identified out of which 42 proteins were unique to the microorganism. The study identified 15 membrane localized drug targets. Amongst these 15, molecular modeling and structure validation of the five membrane localized drug target proteins could only be achieved because of the low sequence identity of the remaining proteins with RCSB structures. These 3D structures can be further characterized by invitro and invivo studies for the development of novel vaccine epitopes and novel antibiotic therapy against Borrelia burgdorferi. PMID: 21814395 [PubMed - in process] (Source: Bioinformation)


Friday 5 August 2011

Antibodies linked to long-term Lyme symptoms

Researchers find molecules that might mark elusive syndrome. (Source: news@nature.com)

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Friday 5 August 2011

Population genetics, taxonomy, phylogeny and evolution of Borrelia burgdorferi sensu lato.

Authors: Margos G, Vollmer SA, Ogden NH, Fish D Abstract In order to understand the population structure and dynamics of bacterial microorganisms, typing systems that accurately reflect the phylogenetic and evolutionary relationship of the agents are required. Over the past 15years multilocus sequence typing schemes have replaced single locus approaches, giving novel insights into phylogenetic and evolutionary relationships of many bacterial species and facilitating taxonomy. Since 2004, several schemes using multiple loci have been developed to better understand the taxonomy, phylogeny and evolution of Lyme borreliosis spirochetes and in this paper we have reviewed and summarized the progress that has been made for this important group of vector-borne zoonotic bacteria. PMID: ...


Thursday 4 August 2011

Interferon-γ Influences the Composition of Leukocytic Infiltrates in Murine Lyme Carditis.

Authors: Sabino GJ, Hwang SJ, McAllister SC, Mena P, Furie MB Interferon (IFN)-γ is present in lesions of patients with Lyme disease and positively correlates with the severity of manifestations. To investigate the role of IFNγ in the development of Lyme carditis, wild-type and IFNγ-deficient C57BL/6 mice were infected with the causative bacterium, Borrelia burgdorferi. Histological analysis revealed no change in the severity of carditis between wild-type and IFNγ-deficient mice at 14, 21, 25, and 28 days after infection. However, a distinct shift in the types of leukocytes within the hearts of IFNγ-deficient mice was observed at 25 days. In the absence of IFNγ, the number of neutrophils in the heart was increased, whereas the number of T lymphocytes was decreased. Bacterial load...


Wednesday 3 August 2011

New Tick-Borne Illness Infects Midwesterners

Experts expect ehrlichiosis, like Lyme disease, will spread across U.S. (Source: Primary Care News - Doctors Lounge)


Wednesday 3 August 2011

New Strain of Tick-Borne Disease Discovered

A new strain of ehrlichiosis, a tick-borne disease, is being spread by deer ticks, the same ticks that spread Lyme disease, anaplasmosis, and babesiosis. (Source: WebMD Health)

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Wednesday 3 August 2011

New Tick-Borne Illness Infects Midwesterners

Experts expect ehrlichiosis, like Lyme disease, will spread across U.S. Source: HealthDay Related MedlinePlus Pages: Lyme Disease, Tick Bites (Source: MedlinePlus Health News)


Wednesday 3 August 2011

New Strain of Tick-Borne Disease Discovered

A new strain of ehrlichiosis, a tick-borne disease, is being spread by deer ticks, the same ticks that spread Lyme disease, anaplasmosis, and babesiosis. (Source: WebMD Health)


Monday 1 August 2011

Burden and viability of Borrelia burgdorferi in skin and joints of patients with erythema migrans or lyme arthritis

ConclusionB burgdorferi in the skin lesions of EM patients were active and viable, whereas those in the SF of LA patients were moribund or dead at any time point. Thus, detection of B burgdorferi DNA in SF is not a reliable test of active joint infection in Lyme disease. (Source: Arthritis and Rheumatism)


Friday 29 July 2011

Video: Dr. Ashton answers viewer health questions

CBS News medical correspondent Dr. Jennifer Ashton answers viewer health questions on issues like high blood pressure, hydrating in the heat, lyme disease and food allergies. (Source: Health News: CBSNews.com)


Thursday 28 July 2011

Two Cases of Orbital Myositis as a Rare Feature of Lyme Borreliosis

We report the case of two patients who presented with focal orbital myositis which are rare localization for Lyme disease. Myositis were confirmed by magnetic resonance imaging. Diagnosis criteria for Borrelia burgdorferi (B. burgdorferi) infection was supported by (i) medical history (tick bite in an endemic area), (ii) systemic clinical findings (Erythema migrans, neurological manifestation or arthritis), (iii) positive Lyme serology and/or the detection of B. burgdorferi DNA by polymerase chain reaction, as well as (iv) exclusion of other infectious and inflammatory causes. The current cases are reviewed in the context of findings fr...

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Tuesday 26 July 2011

LYME (Baptisia Tinctoria, Echinacea, Hydrastis Canadensis, Arsenicum Album, Bryonia, Chelidonium Majus, Colchicum Autumnale Kalmia Latifolia,) Liquid [Apotheca Company]

Updated Date: Jul 26, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))


Saturday 23 July 2011

[Clinical Picture] Dermacentor tick attached to tympanic membrane

In June, 2008, a 47-year-old woman presented to us with a 1-day history of crackling sensations in her left ear. On otoscopic examination, a tick was seen on the left tympanic membrane (). An otorhinolaryngologist removed the tick with endoscopic-guided forceps. There was no bleeding, perforation, hearing loss, or other sequelae. The crackling sensations resolved immediately. The tick was identified as Dermacentor variabilis, commonly known as the American dog tick. Our patient lived in a rural area of Minnesota, USA where the tick-borne diseases lyme and human anaplasmosis are endemic. (Source: LANCET)


Thursday 21 July 2011

Molecular characterization of the Borrelia burgdorferi in vivo essential protein, PncA.

Authors: Jewett M, Jain S, Linowski AK, Sarkar A, Rosa PA The conversion of nicotinamide to nicotinic acid by nicotinamidase enzymes is a critical step in maintaining NAD+ homeostasis and contributes to numerous important biological processes in diverse organisms. In B. burgdorferi, the nicotinamidase enzyme, PncA, is required for spirochete survival throughout the infectious cycle. Mammals lack nicotinamidases and therefore PncA may serve as a therapeutic target for Lyme disease. Contrary to the in vivo importance of PncA, the current annotation for the pncA open reading frame suggests that the encoded protein may be inactive due to the absence of an N-terminal aspartic acid residue that is a conserved member of the catalytic triad of characterized PncA proteins. Herein we used geneti...


Wednesday 20 July 2011

Antibody profiling Borrelia burgdorferi infection in horses.

Authors: Burbelo PD, Bren KE, Ching KH, Coleman A, Yang X, Kariu T, Iadarola MJ, Pal U Infection with Borrelia burgdorferi (Bb) is common in horses and ponies from the New England and Mid-Atlantic regions of the United States. Here, we evaluated Luciferase Immunoprecipitation Systems (LIPS) for profiling antibody responses against three different antigenic targets for the diagnosis of equine Bb infection. LIPS testing of horse serum samples suspected of Lyme infection revealed that approximately 75% of the horse samples (114/159) were seropositive against the synthetic VOVO antigen comprising repeated immunodominant C6 epitopes, as well as OspC immunodominant epitopes. Comparison of VOVO with immunofluorescence assay (IFA) showed that 51% of the samples were co-positive in both assays,...


Tuesday 19 July 2011

Lyme disease detected in the province

Albertans should take precautions against Lyme disease as ticks carrying the disease have been identified in the province. So far this year, 5 ticks have tested positive for Borrelia burgdorferi, the bacteria that causes Lyme disease. The ticks were found on 4 dogs and a cat. These pets live in the Calgary and Edmonton areas and the ticks were submitted by veterinarians to Alberta Agriculture and Rural Development (ARD) for testing. A bite by an infected tick can cause illness in people, wildlife and domestic animals if the tick remains attached for longer than 24 hours. (Source: Alberta.ca from- Health and Wellness)

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Wednesday 13 July 2011

Lyme doctor with troubled past offers controversial treatment

Banned from surgery, ex-Illinois physician now specializes in disease that's doubted by key medical groupsWhen Dr. Jeffrey Piccirillo moved to Grinnell, Iowa, the surgeon had been sued multiple times over allegations of malpractice, personal injury and negligence. (Source: L.A. Times - Health)


Monday 11 July 2011

Clue to What Makes Lyme Bacteria Tick

Mice infected with the Lyme bacteria exhibited an unusual immune response that may explain why Lyme disease recurs in some people, researchers found. (Source: WSJ.com: Health)


Monday 11 July 2011

Heads Up For Lyme Disease This Season And Ways To Defend

Watch out for ticks! The Tick is a cartoon, a square-jawed, muscular, bright blue-costumed figure with antennae sticking up from his head, but we are actually talking about the bugs which happen to be the leading cause of lyme disease (LD). LD manifests itself as a multisystem inflammatory disease that affects the skin in its early, localized stage, and spreads to the joints, nervous system and, to a lesser extent, other organ systems in its later, disseminated stages. If diagnosed and treated early with antibiotics, LD is almost always readily cured... (Source: Health News from Medical News Today)


Monday 11 July 2011

Lyme disease on rise in Wisconsin

MILWAUKEE, July 10 (UPI) -- With the infection rate of Lyme disease climbing, some Wisconsin residents say doctors in the state need to step up their game when it comes to treatment. (Source: Health News - UPI.com)


Friday 8 July 2011

A deadly new reason to avoid deer ticks

Move over, Lyme disease: Another tick-borne illness is on the rise in various parts of the country, and this one can kill. (Source: USATODAY.com Health)


Thursday 7 July 2011

Detection of Borrelia burgdorferi Sensu Lato and Anaplasma phagocytophilum in Small Mammals and Ectoparasites in Hungary

Vector-Borne and Zoonotic Diseases , Vol. 0, No. 0. (Source: Vector-Borne and Zoonotic Diseases)


Thursday 7 July 2011

Lyme borreliosis in Europe

(Source: Eurosurveillance latest news)


Wednesday 6 July 2011

A Deadly New Reason to Avoid Deer Ticks

A little-known illness they're spreading can be fatal, especially to people with a weak immune system Source: HealthDay Related MedlinePlus Pages: Lyme Disease, Tick Bites (Source: MedlinePlus Health News)


Tuesday 5 July 2011

Antiphospholipid antibodies in patients with purported "chronic lyme disease"

Conclusion: aPL occurs frequently in patients with 'CLD'. IgM anti-β2GP1, IgM aCL and IgM WB were frequently found. Documented PLS or LLD was uncommon. The role of aPL in patients with 'CLD' needs further investigation. PMID: 21729977 [PubMed - as supplied by publisher] (Source: Lupus)

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Saturday 2 July 2011

[News of the Week] Newsmakers

This week's Newsmakers are southern California bond financier Jonathan Thomas, who has just been elected to be the next chair of the California Institute for Regenerative Medicine; Russian astrophysicist Rashid Sunyaev and American chemist John Cahn, who have won the Kyoto Prize from the Japanese Inamori Foundation; and microbiologist Phillip Baker, who has been urging PBS affiliate stations not to show the 2008 documentary Under Our Skin, which presents the view that Lyme disease can become chronic, a view that is at odds with mainstream medicine and treatment guidelines. (Source: Science: Current Issue)


Friday 1 July 2011

[Arthritis and clinical history].

Authors: Silva L, Sampaio L, Pinto J, Ventura FS Abstract In front of a patient with arthritis, clinical good-sense tells that the most probable diagnosis are the most prevalent ones. Nevertheless, we have to exclude a multiplicity of other aetiologies, less frequent, but with highest implications in the therapeutic conduct. Infections by Brucella and by Borrelia are rare causes of chronic arthritis, yet are diagnosis to consider, even when the clinical manifestations aren't the most typical, as there still exist endemic areas in Portugal. Here we report two clinical cases about patients with arthritis for more than one year, subject to ineffective exams ant treatments. Only the clinical history could put on evidence clinical-epidemiological data, suggestive of Brucellosis and Lyme...


Wednesday 29 June 2011

Video: Babesiosis: Illness ticks spread on the rise

Debbye Turner Bell reports on the dangerous blood disease Babesiosis, spread by the same ticks that cause Lyme Disease, and gives some important information on how at-risk patients can protect themselves. (Source: Health News: CBSNews.com)


Tuesday 28 June 2011

Detection of anaplasma bovis in an undescribed tick species collected from the eastern rock sengi elephantulus myurus.

DETECTION OF ANAPLASMA BOVIS IN AN UNDESCRIBED TICK SPECIES COLLECTED FROM THE EASTERN ROCK SENGI ELEPHANTULUS MYURUS. J Parasitol. 2011 Jun 28; Authors: Harrison A, Bown K, Horak I Abstract Ticks are important vectors of numerous pathogens causing illness, fatalities, and economic loss worldwide. Infectious disease episodes are increasing and novel tick-borne pathogens are described frequently. Identification of novel reservoir hosts and vectors of tick-borne pathogens are essential if control measures are to be successful. In South Africa, the eastern rock sengi, Elephantulus myurus, hosts a number of tick species of veterinary importance. Despite this, there remains a paucity of information regarding the tick fauna of this species, the pathogen associations of ticks that it ...


Monday 27 June 2011

Lyme disease symptoms? Bull's-eye rash isn't whole story

Residents in high-risk areas should look for symptoms that start as flu-like but may turn into serious complications (Source: Health News: CBSNews.com)

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Monday 27 June 2011

Molecular Characterization of Novel Sulfotransferases from the tick, Ixodes scapularis

Conclusions: Collectively, these results suggest that a function of Ixosc Sult 1 and Sult 2 in Ixodid tick salivary glands may include inactivation of the salivation signal via sulfonation of dopamine or octopamine. (Source: BMC Biochemistry)


Friday 24 June 2011

Lyme disease self-defense? It's more than bug spray

Lyme disease cases have tripled since 1995, 95 percent of cases occur in 12 states (Source: Health News: CBSNews.com)


Friday 24 June 2011

Borrelia infection in ticks in Norway

The most common tick-borne disease in humans is Lyme borreliosis. Extensive field and laboratory tests have revealed that the Borrelia bacterium is present in a larger proportion of ticks than has been shown by earlier studies. Another finding is that migratory birds play an important role in the spreading of ticks and pathogenic agents borne by ticks. (Source: ScienceDaily Headlines)


Friday 24 June 2011

Introduced Siberian chipmunks (Tamias sibiricus barberi) harbour more diverse Borrelia burgdorferi sensu lato genospecies than native bank voles (Myodes glareolus).

In this study, we investigated whether an introduced species, the Siberian chipmunk (Tamias sibiricus barberi), was a potentially new reservoir host for Borrelia burgdorferi sensu lato (sl), causative agents of Lyme disease. First, we ascertained whether chipmunks were infected by all of the B. burgdorferi sl genospecies associated with rodents and available in their source of infection, questing nymphs. Second, we determined whether the prevalence and diversity of B. burgdorferi sl in chipmunks was similar to that of a native reservoir rodent, the bank vole (Myodes glareolus). Our research took place between 2006 and 2008 in a suburban French forest, where we trapped 335 chipmunks and 671 voles, and collected 743 nymphs of ticks that are questing for hosts by dragging on the vegetation. W...


Thursday 23 June 2011

Adaptation By Lyme Disease Tick

A new study offers a detailed look at the status of Lyme disease in Central Illinois and suggests that deer ticks and the Lyme disease bacteria they host are more adaptable to new habitats than previously appreciated. Led by researchers at the University of Illinois, the study gives an up-close view of one region affected by the steady march of deer ticks across the upper Midwest. Their advance began in Wisconsin and Minnesota and is moving at a pace of up to two counties a year in Illinois and Indiana... (Source: Health News from Medical News Today)

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Tuesday 21 June 2011

Well: A New Worry About Tick Bites

A potentially devastating infection caused by tick bites is showing up on the East Coast, government researchers have found. (Source: NYT Health)


Tuesday 21 June 2011

Lyme disease tick adapts to life on the (fragmented) prairie

(University of Illinois at Urbana-Champaign) A new study offers a detailed look at the status of Lyme disease in Central Illinois and suggests that deer ticks and the Lyme disease bacteria they host are more adaptable to new habitats than previously appreciated. (Source: EurekAlert! - Medicine and Health)


Tuesday 21 June 2011

Ixodes scapularis and Borrelia burgdorferi Among Diverse Habitats Within a Natural Area in East-Central Illinois

Vector-Borne and Zoonotic Diseases , Vol. 0, No. 0. (Source: Vector-Borne and Zoonotic Diseases)


Monday 20 June 2011

Once Rare, Infection by Tick Bites Spreads

Another infection caused by tick bites is spreading in the Lower Hudson Valley, and in other parts of the Northeast and the Upper Midwest. (Source: NYT Health)

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Saturday 18 June 2011

Cutaneous lymphoid hyperplasia related to squaric acid dibutyl ester

To the Editor: Cutaneous lymphoid hyperplasia (CLH) is a reactive lymphocytic process with clinical and histologic features resembling lymphoma. It has been called pseudolymphoma, lymphocytoma cutis, lymphadenosis benigna cutis, and Spiegler–Fendt sarcoid, among other names. While many cases remain idiopathic, common causes include Borrelia burgdorferi, insect bites or infestations, viral infections, vaccinations, tattoos, and medications (particularly phenytoin). Herein, we present a case of CLH related to squaric acid dibutyl ester (SADBE) sensitization. (Source: Journal of the American Academy of Dermatology)


Friday 17 June 2011

Lyme Disease Bacteria Take Cover In Lymph Nodes

The bacteria that cause Lyme disease, one of the most important emerging diseases in the United States, appear to hide out in the lymph nodes, triggering a significant immune response, but one that is not strong enough to rout the infection, report researchers at the University of California, Davis. Results from this groundbreaking study involving mice may explain why some people experience repeated infections of Lyme disease. The study appears online in the journal Public Library of Science Biology.... (Source: Health News from Medical News Today)


Friday 17 June 2011

Lyme disease bacteria take cover in lymph nodes

The bacteria that cause Lyme disease appear to hide out in the lymph nodes, triggering a significant immune response, but one that is not strong enough to rout the infection, report researchers. (Source: ScienceDaily Headlines)


Wednesday 15 June 2011

Healthcare access and burden of care for patients with Lyme disease: A large United States survey

Conclusions: Lyme disease patients frequently endure extensive delays in obtaining an initial diagnosis, have poor access to healthcare and suffer a severe burden of illness. (Source: Health Policy)

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Thursday 9 June 2011

Seeing the blocks: MRI of the brachial plexus in multifocal motor neuropathy

Case summary A 45-year-old man presented with 3 months of progressive right hand weakness. Examination showed mild atrophy and weakness of the right hand, and absent tendon reflexes. Cerebrospinal fluid contained 0.42 g/l protein (normal <0.45) and 1 lymphocyte/mm3. Electrodiagnostic studies revealed a multifocal motor neuropathy (MMN) with partial conduction blocks and severe denervation in the muscles of the right hand (figure 1). Sensory nerve conduction studies were normal. Charcot–Marie–Tooth disease, distal demyelinating polyneuropathy associated with monoclonal gammapathy, Lyme disease, lymphoma and malignant plasma cell dyscrasia were excluded using relevant biological, electrophysiological and genetic studies.1 The search for IgM anti-ganglioside GM1 ...


Wednesday 8 June 2011

Biodiversity and leptospirosis risk: A case of pathogen regulation?

Abstract: Well balanced ecosystems have an essential role in disease regulation, and consequently their correct functioning is increasingly recognised as imperative for maintaining human health. Disruptions to ecosystems have been found to increase the risk of several diseases, including Hantavirus, Lyme disease, Ross River virus, malaria and Ciguatera fish poisoning. Leptospirosis is a globally important emerging zoonosis, caused by spirochaete bacteria, borne by many mammalian hosts, and also transmitted environmentally. We propose that leptospirosis incidence in humans is also linked to ecosystem disruption, and that reduced biodiversity (the diversity of species within an ecological community) may be associated with increased leptospirosis incidence. To investigate this hypothesis, the...


Monday 6 June 2011

Tracking outbreaks online

flickr/warrentedarrest Are you looking to read reviews about the new Greek restaurant that opened up down the street? Google it. In an argument about who drove in the final runs in the Red Sox’s 2004 world series run? Google is right there to let you know it was Trot Nixon. While most of us use Google for seemingly trivial purposes, (I know Sox fans, ’04 was anything BUT trivial in your eyes) researchers at Children’s Hospital Boston are using the powerful search engine to fight disease. John Brownstein, PhD A team from the Children’s Hospital Informatics Program (CHIP), led by John Brownstein, PhD, put their heads together with people from Google and found that web-based search data is a great info sharing source for citizens and public health officials alike. With this in m...


Thursday 2 June 2011

Prevention of Lyme Disease: Promising Research or Sisyphean Task?

Abstract   Borrelia burgdorferi sensu lato (Spirochaetes) is a group of at least 12 closely related species, some of which are responsible for chronic zoonotic infection that may cause Lyme disease. The only experimentally confirmed vector transmitting Borrelia to mammals is the Ixodes ticks. Borrelia is a highly adapted pathogen that can survive in the host organism in spite of the intense immune responses. Some patients have chronic long-lasting complications despite antibiotic therapy, probably due to adverse effects of the immune responses. A preventive vaccine against this bacterium has not been available due to the relatively broad spectrum and antigenic variability of Borrelia-surface lipoproteins and the different epitope recognition by experimental animals and human...


Thursday 2 June 2011

Acylated cholesteryl galactosides are ubiquitous glycolipid antigens among Borrelia burgdorferi sensu lato

AbstractLyme disease (LD) is the most common tick‐borne disease in the Northern hemisphere. It is caused by Borrelia burgdorferi sensu lato, in particular B. burgdorferi sensu stricto, B. garinii and B. afzelii. However, other genospecies have been implicated as causative factors of LD as well. B. burgdorferi exhibits numerous immunogenic lipoproteins, but due to strong heterogeneity, the use of these proteins for serodiagnosis and vaccination is hampered. We and others have identified acylated cholesteryl galactosides (ACGal) as a novel glycolipid present in B. burgdorferi sensu stricto, B. afzelii and B. garinii. ACGal is a strong antigen and the majority of patients display anti‐ACGal antibodies in chronic stages of LD. However, it is unknown whether ACGal is present in other presum...

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Wednesday 1 June 2011

Ticked Off

DR. WILKOFF practices general pediatrics in a multispecialty group practice in Brunswick, Maine. I recently surveyed my partners and learned that over the last 5 years, they have lost only two patients to “chronic Lyme disease.” Considering that we've got droves of ticks, we should be proud of that statistic – but when I say “lost,” I'm not referring to mortality. Although we have seen plenty of Lyme disease and one young man ended up in the ICU with heart block, we haven't had any deaths that could be attributed to the disease. The losses I am referring to are patients who found their ways to other physicians and were diagnosed with chronic Lyme disease. (Source: Pediatric News)


Wednesday 1 June 2011

Babesia canis rossi infection in a Texas dog

Abstract: A 5‐month‐old intact male Boerboel dog, imported from South Africa 1 week previously, was presented to a Texas veterinarian for lethargy, anorexia, and labored breathing. The dog was febrile, anemic, leukopenic, thrombocytopenic, and slightly azotemic. Results of the IDEXX SNAP‐4Dx enzyme immunoassay were negative for Dirofilaria immitis antigen and antibodies against Ehrlichia canis, Borrelia burgdorferi, and Anaplasma phagocytophilum. An EDTA blood sample analyzed at Oklahoma State University Center for Veterinary Health Sciences revealed nonregenerative anemia, neutropenia, and large protozoal piroplasms in 0.7% of the RBCs. Piroplasms were 2–5 μm long and varied in shape from round to oval to piriform; extracellular merozoites were also observed. Nested PCR was per...

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Wednesday 1 June 2011

Molecular evidence of vector-borne pathogens coinfecting dogs from Poland.

Authors: Rymaszewska A, Adamska M Ticks of the genus Ixodes are vectors for many pathogens, including Borrelia burgdorferi sensu lato, Anaplasma phagocytophilum and Rickettsia spp., and may also serve as vectors for Bartonella spp. However, the role of ticks in Bartonella transmission requires additional studies. The aim of this study was to investigate whether coinfection with two or more vector-borne pathogens can occur in the following three groups of dogs: I - dogs with suspected borreliosis (N = 92), II - dogs considered healthy (N = 100), and III - dogs with diagnosed babesiosis (N = 50). Polymerase chain reactions were performed to detect DNA of Anaplasma phagocytophilum, Rickettsia spp. and Bartonella spp. in the blood of dogs. In dogs of Group I, the DNA of both A. phagocytoph...


Wednesday 1 June 2011

Borrelia burgdorferi RST1 (OspC Type A) Genotype Is Associated with Greater Inflammation and More Severe Lyme Disease.

Authors: Strle K, Jones KL, Drouin EE, Li X, Steere AC Evidence is emerging for differential pathogenicity among Borrelia burgdorferi genotypes in the United States. By using two linked genotyping systems, ribosomal RNA intergenic spacer type (RST) and outer surface protein C (OspC), we studied the inflammatory potential of B. burgdorferi genotypes in cells and patients with erythema migrans or Lyme arthritis. When macrophages were stimulated with 10 isolates of each RST1, RST2, or RST3 strain, RST1 (OspC type A)-stimulated cells expressed significantly higher levels of IL-6, IL-8, chemokine ligand (CCL) 3, CCL4, tumor necrosis factor, and IL-1β, factors associated with innate immune responses. In peripheral blood mononuclear cells, RST1 strains again stimulated significantly higher l...


Wednesday 1 June 2011

Lyme borreliosis in south-eastern Poland: relationships with environmental factors and medical attention standards.

Authors: Bartosik K, Lachowska-Kotowska P, Szymanska J, Pabis A, Buczek A Yhe aim of the study was the investigation of the dynamics of LB prevalence in central Europe over a 12-year period and estimation of its dependence on the environmental factors and on the level of medical services. Epidemiological studies of LB were conducted in the years 1996-2007 in 9 regions of the Swietokrzyskie province in south-eastern Poland (Central Europe). On the basis of patient registry, the incidence, prevalence in various months of the year, the mean number of cases in various seasons and the seasonality factors (SF) of LB were calculated. Between 2000-2007, an increased borreliosis incidence was observed in the study area. During the entire study period, the highest incidence (25.93 and 30.66) was...


Monday 30 May 2011

Erythema migrans in Lyme disease.

Authors: Wetter DA, Ruff CA PMID: 21624904 [PubMed - as supplied by publisher] (Source: cmaj)


Monday 30 May 2011

Retrospective Study on Seroprevalence of Borrelia burgdorferi Antibodies in Horses in Minnesota

Abstract: To determine the seroprevalence of Borrelia burgdorferi antibodies in horses in Minnesota, the database of the Veterinary Diagnostic Laboratory, University of Minnesota, was searched over a 10-year period (May 2001 to May 2010). A total of 1,260 equine serum samples submitted by 112 veterinary clinics were tested using an indirect fluorescent antibody test. Samples with titers of ≥1:320 were considered positive. The average rate of seroprevalence was 58.7%, indicating high exposure of horses to B burgdorferi in Minnesota. Our results indicate that borreliosis should be considered as a differential in cases of horses with undiagnosed musculoskeletal or neurologic disease. (Source: Journal of Equine Veterinary Science)


Friday 27 May 2011

Uveitis: When a Vitrectomy Is More Than Just a Treatment

Uveitis is an ocular inflammatory disease that can present as anterior, intermediate, posterior, or panuveitic. Although the etiology in most cases is idiopathic, many infectious and inflammatory diseases such as Lyme disease, syphilis, tuberculosis, sarcoidosis, and spondyloarthritis can be associated with it. The outcome of untreated uveitis can be vision-threatening, therefore it is important to initiate early treatment and rule out any systemic associations when warranted. Determining the etiology can be difficult, especially in bilateral and non-resolving cases. Diagnostic tools include history, clinical presentation, infectious/inflammatory blood work, and in rare cases, a diagnostic vitrectomy. (Source: Optometry - Journal of the American Optometric Association)


Thursday 26 May 2011

Factors Affecting Duration of Chronic Fatigue Syndrome in Pediatric Patients

Conclusions  BMI is significantly associated with prolonged duration of CFS. Content Type Journal ArticlePages 1-4DOI 10.1007/s12098-011-0463-4Authors Dmitriy Petrov, UMDNJ/Robert Wood Johnson Medical School, New Brunswick, NJ, USADaniel Marchalik, UMDNJ/Robert Wood Johnson Medical School, New Brunswick, NJ, USAMichael Sosin, UMDNJ/Robert Wood Johnson Medical School, New Brunswick, NJ, USAAswine Bal, Department of Pediatrics, Jersey Shore University Medical Center, 1945 Corlies Avenue, Neptune, NJ 07754, USA Journal Indian Journal of PediatricsOnline ISSN 0973-7693Print ISSN 0019-5456 (Source: Indian Journal of Pediatrics)


Thursday 26 May 2011

Tick Saliva Represses Innate Immunity and Cutaneous Inflammation in a Murine Model of Lyme Disease

Vector-Borne and Zoonotic Diseases , Vol. 0, No. 0. (Source: Vector-Borne and Zoonotic Diseases)

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Thursday 26 May 2011

Serological Reactivity to Borrelia burgdorferi Sensu Lato in Dogs and Horses from Distinct Areas in Romania

Vector-Borne and Zoonotic Diseases , Vol. 0, No. 0. (Source: Vector-Borne and Zoonotic Diseases)


Thursday 26 May 2011

The Importance of Ixodes arboricola in Transmission of Rickettsia spp., Anaplasma phagocytophilum, and Borrelia burgdorferi Sensu Lato in the Czech Republic, Central Europe

Vector-Borne and Zoonotic Diseases , Vol. 0, No. 0. (Source: Vector-Borne and Zoonotic Diseases)


Thursday 26 May 2011

Comparison of Erythema Migrans Caused by Borrelia burgdorferi and Borrelia garinii

Vector-Borne and Zoonotic Diseases , Vol. 0, No. 0. (Source: Vector-Borne and Zoonotic Diseases)


Wednesday 25 May 2011

Lyme disease lies - and truths

Lyme disease season is just around the corner. Do you know how to protect your family? (Source: Health News: CBSNews.com)


Wednesday 25 May 2011

Prevention of Vector Transmitted Diseases With Clove Oil Insect Repellent

This article will explore the safety and effectiveness of clove oil and its use as an insect repellent. (Source: Journal of Pediatric Nursing)

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Wednesday 25 May 2011

Interleukin-35 Enhances Lyme Arthritis in Borrelia-Vaccinated and -Infected Mice.

Authors: Kuo J, Nardelli DT, Warner TF, Callister SM, Schell RF Interleukin-35 (IL-35) has been reported to inhibit the production of interleukin-17 (IL-17) as a means of preventing arthritis and other inflammatory diseases. We previously showed that treatment of Borrelia-vaccinated and -infected mice with anti-IL-17 antibody at the time of infection prevented the development of arthritis. These anti-IL-17 antibody-treated mice lack extensive tissue damage, such as bone and cartilage erosion, that occurred in the tibiotarsal joints of untreated Borrelia-vaccinated and -infected control mice. We hypothesized that IL-35 would reduce the severity of arthritis by suppressing the production of IL-17 in Borrelia-vaccinated and -infected mice. Here, we show that administration of recombinant ...


Tuesday 24 May 2011

VIDEO: Top tips for avoiding ticks

Jolyon Medlock from the Health Protection Agency's tick surveillance project explains how we can catch Lyme disease from ticks and what we can do to protect ourselves. (Source: BBC News | Health | UK Edition)


Tuesday 24 May 2011

VIDEO: Tick attack

What is Lyme disease and how do you protect yourself? (Source: BBC News | Health | UK Edition)


Saturday 21 May 2011

Lyme disease tripled from 1992 to 2009

ATLANTA, May 21 (UPI) -- The reported annual number of U.S. Lyme disease cases tripled from 1992 to 2009, with children most at risk for the disease, federal health officials say. (Source: Health News - UPI.com)


Saturday 21 May 2011

Barnstable Lyme Disease Program Has New Tool To Fight Deer Ticks

Researchers on the Cape are hoping a plastic contraption called the Four Poster Deer Feeding Station is part of the solution to a growing threat of Lyme disease. (Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire)


Friday 20 May 2011

CDC Observes Lyme Disease Awareness Month

In recognition of Lyme Disease Awareness month, the Centers for Disease Control and Prevention reminds Americans to learn about this common tickborne disease and take steps to protect themselves if they live in or visit areas with Lyme disease activity. Lyme disease is the most commonly reported vectorborne illness (or disease transmitted to humans by ticks, mosquitoes or fleas) in the United States, with nearly 30,000 confirmed cases reported in 2009... (Source: Health News from Medical News Today)


Wednesday 18 May 2011

A host-restricted viral vector for antigen-specific immunization against Lyme disease pathogen.

Authors: Xiao S, Kumar M, Yang X, Akkoyunlu M, Collins PL, Samal SK, Pal U Newcastle disease virus (NDV) is an avian virus that is attenuated in primates and is a potential vaccine vector for human use. We evaluated NDV as a vector for expressing selected antigens of the Lyme disease pathogen Borrelia burgdorferi. A series of recombinant NDVs were generated that expressed intracellular or extracellular forms of two B. burgdorferi antigens: namely, the basic membrane protein A (BmpA) and the outer surface protein C (OspC). Expression of the intracellular and extracellular forms of these antigens was confirmed in cultured chicken cells. C3H or Balb/C mice that were immunized intranasally with the NDV vectors mounted vigorous serum antibody responses against the NDV vector, but failed to ...


Tuesday 17 May 2011

PCR Not a Reliable Test for Active Lyme Arthritis

Patients who still have arthritis after 2 to 3 months of oral and intravenous antibiotics are unlikely to harbor live Borrelia burgdorferi in synovial fluid or tissue and should receive DMARDs. Medscape Medical News (Source: Medscape Today Headlines)


Tuesday 17 May 2011

Deer tick bacteria DNA in joint fluid not reliable marker of active lyme arthritis

(Wiley-Blackwell) New research shows that polymerase chain reaction testing for Borrelia burgdorferi DNA -- the spirochetal bacteria transmitted by deer ticks -- in joint fluid may confirm the diagnosis of Lyme arthritis, but is not a reliable indicator for active joint infection in patients whose arthritis persists after antibiotic therapy. Findings of this study are published in Arthritis & Rheumatism, a journal of the American College of Rheumatology. (Source: EurekAlert! - Medicine and Health)

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Tuesday 17 May 2011

Deer Tick Bacteria DNA In Joint Fluid Not Reliable Marker Of Active Lyme Arthritis

New research shows that polymerase chain reaction (PCR) testing for Borrelia burgdorferi DNA-the spirochetal bacteria transmitted by deer ticks-in joint fluid may confirm the diagnosis of Lyme arthritis, but is not a reliable indicator for active joint infection in patients whose arthritis persists after antibiotic therapy. Findings of this study are published in Arthritis & Rheumatism, a journal of the American College of Rheumatology (ACR). Lyme disease is caused by the B... (Source: Health News from Medical News Today)


Tuesday 17 May 2011

Burden and viability of Borrelia burgdorferi in skin or joints, of patients with erythema migrans or lyme arthritis

Conclusion.B. burgdorferi in EM lesions were active and viable, whereas those in SF were moribund or dead at any time point. Thus, detection of B. burgdorferi DNA in SF is not a reliable test of active joint infection in Lyme disease. (Source: Arthritis and Rheumatism)


Monday 16 May 2011

What Causes Vertigo in Children?

Discussion Dizziness is an abnormal sensation relative to position and space which is often vague. It includes imbalance, motion intolerance, light-headedness, unsteadiness, floating or tilting sensations. Dizziness can be caused by cardiovascular, CNS or systemic diseases. Vertigo is a subtype of dizziness that has a rotary or spinning sensation. Objects rotate around the patient or the patient rotates around the objects. Vertigo is usually categorized into peripheral or central causes. Central vertigo emanates from a CNS location, and may have other CNS symptoms such as headaches, aura, motor, sensory or visual symptoms such as tinnitis or hearing loss. Symptoms usually last longer and may increase in number, frequency or intensity. Peripheral vertigo emanates from a non-CNS location an...


Friday 13 May 2011

Deadly Lyme disease on increase as more of us spend time outdoors

Why a tick bite could ruin your summer if you develop Lyme Disease (Source: Telegraph Health)


Thursday 12 May 2011

Nitrosative Damage to Free and Zinc‐bound Cysteine Thiols Underlies Nitric Oxide Toxicity in Wild‐type Borrelia burgdorferi

In this study, diethylamine NONOate (DEA/NO) was used to characterize the lethal effects of RNS on B. burgdorferi. RNS produce a variety of DNA lesions in a broad spectrum of microbial pathogens, however, levels of the DNA deamination product, deoxyinosine, and the numbers of apurinic/apyrimidinic (AP) sites were identical in DNA isolated from untreated and DEA/NO‐treated B. burgdorferi cells. Strains with mutations in the nucleotide excision repair (NER) pathway genes uvrC or uvrB treated with DEA/NO had significantly higher spontaneous mutation frequencies, increased numbers of AP sites in DNA and reduced survival compared to wild‐type controls. Polyunsaturated fatty acids in B. burgdorferi cell membranes, which are susceptible to peroxidation by reactive oxygen species (ROS), were n...

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Monday 9 May 2011

The Tick: May Is Heads Up For Lyme Disease Month

Watch out for ticks! The Tick is a cartoon, a square-jawed, muscular, bright blue-costumed figure with antennae sticking up from his head, but we are actually talking about the bugs which happen to be the leading cause of lyme disease (LD). LD is a real thing and this month happens to be LD Awareness Month. LD manifests itself as a multisystem inflammatory disease that affects the skin in its early, localized stage, and spreads to the joints, nervous system and, to a lesser extent, other organ systems in its later, disseminated stages... (Source: Health News from Medical News Today)


Sunday 8 May 2011

Lyme Disease Cases Rose 21% In Minnesota, Human Anaplasmosis Rate Rose Rapidly

A record number of people in Minnesota were infected with tick-borne diseases in 2010. With the arrival of the 2011 tick season, authorities are urging people to be especially careful to protect themselves from the black-legged tick. The black-legged tick, also known as the deer tick, carries the three most common tick-born diseases, and some others. According to MDH (Minnesota Department of Health), the total number of reported cases in 2010 in the state were: Babesiosis - 31 cases in 2009... (Source: Health News from Medical News Today)


Thursday 5 May 2011

State Activates Dead Bird Reporting Hotline to Track West Nile Virus

Lyme disease cases increased 35 percent in 2010, and state health officials are urging people to take precautions against tick bites as warm spring weather triggers more "blacklegged" or "deer" tick activity. Infected blacklegged ticks can carry Lyme disease and other tick-borne diseases including anaplasmosis, ehrlichiosis, and babesiosis. (Source: Wisconsin DHFS Press Releases)


Thursday 5 May 2011

Lyme Disease Remains a Health Threat in Wisconsin

Lyme disease cases increased 35 percent in 2010, and state health officials are urging people to take precautions against tick bites as warm spring weather triggers more "blacklegged" or "deer" tick activity. Infected blacklegged ticks can carry Lyme disease and other tick-borne diseases including anaplasmosis, ehrlichiosis, and babesiosis. (Source: Wisconsin DHFS Press Releases)


Wednesday 4 May 2011

The diguanylate cyclase, Rrp1, regulates critical steps in the enzootic cycle of the Lyme disease spirochetes

ABSTRACTRrp1 is the sole c‐di‐GMP producing protein (diguanylate cyclase) of Borrelia burgdorferi. To test the hypothesis that Rrp1 regulates critical processes involved in the transmission of spirochetes between ticks and mammals, an rrp1 deletion mutant (B31‐Δrrp1) and a strain that constitutively produces elevated levels of Rrp1 (B31‐OV) were constructed. The strains were assessed for progression through the enzootic cycle using an Ixodes tick/C3H‐HeJ mouse model and tick immersion feeding methods. B31‐Δrrp1 infected mice as efficiently as wild type but had altered motility, decreased chemotactic responses to N‐acetylglucosamine (NAG) and attenuated ability to disseminate or colonize distal organs. While this strain infected mice, it was not able to survive in ticks. In ...

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Wednesday 4 May 2011

[Children Lyme Borreliosis: Retrospective study of 16 cases.]

CONCLUSION: Lyme Borreliosis in children exists in Alsace. Its main demonstration is the erythema migrans, but there are also neurological and articular demonstrations. With an appropriate treatment, its evolution is excellent. PMID: 21549553 [PubMed - as supplied by publisher] (Source: Presse Medicale)


Sunday 1 May 2011

Seroprevalence of Borrelia burgdorferi, Anaplasma phagocytophilum, Ehrlichia canis, and Dirofilaria immitis among dogs in Canada.

Authors: Villeneuve A, Goring J, Marcotte L, Overvelde S Abstract The seropositivity of dogs to Borrelia burgdorferi, Anaplasma phagocytophilum, and Ehrlichia canis antibodies, and Dirofilaria immitis antigen was assessed in Canada. Borrelia burgdorferi had the highest seroprevalence, while that of Dirofilaria immitis has not changed significantly in the past 20 y. The risk for these vector-borne infectious agents in Canadian dogs is low but widespread with foci of higher prevalence. PMID: 22043075 [PubMed - in process] (Source: The Canadian Veterinary Journal)


Sunday 1 May 2011

Bell's Palsy Associated with Chronic HCV Infection Before and During Peginterferon Alfa and Ribavirin Therapy.

Authors: Jabbari H, Fakharzadeh E, Merat S, Zamini H, Sharifi AH Neuropsychiatric side effects of peg interferon-alpha (PEG-IFN-alpha) therapy consist of a large spectrum of symptoms. Organic personality syndrome, organic affective syndrome, psychotic manifestations and seizures are more common side effects of PEG-IFN-alpha whereas cranial neuropathy and movement disorders are less common. Bell's palsy is often idiopathic, but has been linked to some viral infections, particularly with herpes viruses. Other infections, such as human immunodeficiency virus infection and Lyme disease, may also lead to idiopathic facial paralysis. Neither acute nor chronic Hepatitis C infection has been implicated previously in Bell's palsy, but PEG-IFN-alpha  may play a role. Two patients with CHC who d...


Sunday 1 May 2011

Multitarget test for emerging lyme disease and anaplasmosis in a serosurvey of dogs, maine, USA.

Authors: Rand PW, Lacombe EH, Elias SP, Cahill BK, Lubelczyk CB, Smith RP To determine if the range of deer ticks in Maine had expanded, we conducted a multitarget serosurvey of domestic dogs (Canis lupus familiaris) in 2007. An extension of exposure to Borrelia burgdorferi to the northern border and local transmission of Anaplasma phagocytophilum throughout southern areas was found. PMID: 21529407 [PubMed - in process] (Source: Emerging Infectious Diseases)