Search found 20 matches

by Psilociraptor
Mon 27 Aug 2018 7:48
Forum: Published Studies
Topic: Identifying vancomycin as an effective antibiotic for killing Borrelia burgdorferi.
Replies: 4
Views: 2730

Re: Identifying vancomycin as an effective antibiotic for killing Borrelia burgdorferi.

The word "eradication" or "cleared" is frequently used in this paper but the results show continued PCR positivity for ALL antibiotics that were used despite culture negativity. The precedence for a viable but noncultivable state following treatment is established https://www.ncbi.nlm.nih.gov/pubmed...
by Psilociraptor
Sun 26 Aug 2018 1:45
Forum: Published Studies
Topic: Identifying vancomycin as an effective antibiotic for killing Borrelia burgdorferi.
Replies: 4
Views: 2730

Re: Identifying vancomycin as an effective antibiotic for killing Borrelia burgdorferi.

I've only skimmed this, but I have a question. And it's genuinely a question, not a criticism. Why is culture negativity/PCR positivity being interpreted as "eradication" when the mice were sacrificed after two days. If I recall spirochetes have been shown to be cleared within a matter of hours and ...
by Psilociraptor
Wed 11 Jul 2018 2:41
Forum: Published Studies
Topic: Persistent Borrelia Infection in Patients with Ongoing Symptoms of Lyme Disease
Replies: 4
Views: 2882

Re: Persistent Borrelia Infection in Patients with Ongoing Symptoms of Lyme Disease

duncan wrote:I suspect part of the answer lies in testing tissue.
Maybe I missed something, but wasn't it mostly blood and genital secretions? Either way it seems worthy of a discussion since it will obviously be a point of contention for critics.
by Psilociraptor
Fri 6 Jul 2018 15:47
Forum: Published Studies
Topic: Persistent Borrelia Infection in Patients with Ongoing Symptoms of Lyme Disease
Replies: 4
Views: 2882

Re: Persistent Borrelia Infection in Patients with Ongoing Symptoms of Lyme Disease

So... given that post treatment culture failure is half the reason this debate spawned... what exactly did they do differently to make it work here? Seems like they didn't talk much about what they attributed their success to.
by Psilociraptor
Thu 15 Mar 2018 21:29
Forum: Published Studies
Topic: Late Disseminated Lyme Disease: Associated Pathology and Spirochete Persistence Post-Treatment in Rhesus Macaques
Replies: 4
Views: 3012

Re: Late Disseminated Lyme Disease: Associated Pathology and Spirochete Persistence Post-Treatment in Rhesus Macaques

The autoimmune theory is ridiculous. "Proof of cure" is often based on informal fallacy. Ie conflating absence of evidence with evidence of absence. As detection techniques improve more and more of the scientific field is moving away from conventional theories of autoimmunity and towards an interest...
by Psilociraptor
Sat 6 Jan 2018 16:03
Forum: Published Studies
Topic: Isolation of Borrelia s.s/s.l. From Seronegative Antibiotic Treated Patients in the Southern US
Replies: 0
Views: 3215

Isolation of Borrelia s.s/s.l. From Seronegative Antibiotic Treated Patients in the Southern US

Talk about bending the rules lol http://www.sciencedirect.com/science/article/pii/S1198743X1500991X#! Lyme borreliosis is a multisystem disorder with a diverse spectrum of clinical manifestations, caused by spirochaetes of the Borrelia burgdorferi sensu lato complex. It is an infectious disease that...
by Psilociraptor
Sun 17 Dec 2017 0:21
Forum: Published Studies
Topic: Sleeper cells: Stringent response & persistence in BB enzootic cycle
Replies: 2
Views: 2763

Re: Sleeper cells: Stringent response & persistence in BB enzootic cycle

Got around to reading this one finally. Overall pretty interesting, but confusing in sections. There are several statements the authors made that I would love clarified if anyone is capable. For example: " Similarly, since null mutants of Rel and RpoS increase the frequency of round form morphotypes...
by Psilociraptor
Fri 15 Dec 2017 6:32
Forum: Published Studies
Topic: Variable manifestations, diverse seroreactivity and post-treatment persistence in non-human primates exposed to Borrelia
Replies: 2
Views: 2547

Variable manifestations, diverse seroreactivity and post-treatment persistence in non-human primates exposed to Borrelia

M. Embers 2017 Abstract The efficacy and accepted regimen of antibiotic treatment for Lyme disease has been a point of significant contention among physicians and patients. While experimental studies in animals have offered evidence of post-treatment persistence of Borrelia burgdorferi, variations i...
by Psilociraptor
Fri 15 Dec 2017 6:30
Forum: Published Studies
Topic: Late Disseminated Lyme Disease: Associated Pathology and Spirochete Persistence Post-Treatment in Rhesus Macaques
Replies: 4
Views: 3012

Late Disseminated Lyme Disease: Associated Pathology and Spirochete Persistence Post-Treatment in Rhesus Macaques

M. Embers 2017 Abstract Non-human primates currently serve as the best experimental model for Lyme disease due to their close genetic homology with humans and demonstration of all three phases of disease following infection with Borreliella (Borrelia) burgdorferi (Bb). We investigated the pathology ...
by Psilociraptor
Sat 2 Dec 2017 15:56
Forum: Published Studies
Topic: Selective Essential Oils from Spice or Culinary Herbs Have High Activity against Stationary Phase and Biofilm Borrelia b
Replies: 0
Views: 2600

Selective Essential Oils from Spice or Culinary Herbs Have High Activity against Stationary Phase and Biofilm Borrelia b

Selective Essential Oils from Spice or Culinary Herbs Have High Activity against Stationary Phase and Biofilm Borrelia burgdorferi. Although the majority of patients with acute Lyme disease can be cured with the standard 2-4 week antibiotic treatment, about 10-20% of patients continue suffering fro...