Search found 18 matches

by johnholland
Sun 7 Jun 2015 22:22
Forum: Published Studies
Topic: New compounds against stationary borrelia
Replies: 0
Views: 591

New compounds against stationary borrelia

Interesting new research from John Hopkins. http://www.nature.com/emi/journal/v4/n6/full/emi201531a.html Identification of new compounds with high activity against stationary phase Borrelia burgdorferi from the NCI compound collection Lyme disease is the leading tick-borne disease in the USA. Wherea...
by johnholland
Sat 30 May 2015 21:33
Forum: Published Studies
Topic: Borrelia burgdorferi persister cells
Replies: 19
Views: 5848

Re: Borrelia burgdorferi persister cells

This is in vitro research. Ceftriaxone doesn't have intracellular activity.
by johnholland
Mon 18 May 2015 18:31
Forum: Published Studies
Topic: LNB in patient treated with TNF-alpha inhibitor
Replies: 11
Views: 2467

Re: LNB in patient treated with TNF-alpha inhibitor

Question is often what the bioavailability is. Curcumin is absorbed quite poorly orally. This problem have a lot of herbals with good in vitro activity.
by johnholland
Mon 18 May 2015 16:22
Forum: Published Studies
Topic: LNB in patient treated with TNF-alpha inhibitor
Replies: 11
Views: 2467

Re: LNB in patient treated with TNF-alpha inhibitor

I wonder what would happen if you took a late stage NB patient and then added the TNF inhibiotor, similar to the culture the one study did on the entire mouse and then found it recultivable. http://en.wikipedia.org/wiki/TNF_inhibitor "In patients with latent Mycobacterium tuberculosis infection, ac...
by johnholland
Fri 24 Apr 2015 12:27
Forum: Lyme Café
Topic: Is Maple Syrup a Potential Biofilm Buster?
Replies: 11
Views: 5584

Re: Is Maple Syrup a Potential Biofilm Buster?

Hi Rita, In vivo evidence is indeed still lacking for borrelia biofilm. Prof Zhang also found in vitro biofilm for borrelia persisters. http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0117207 Chronic infections are often caused by biofilms. So the assumption that borrelia produces b...
by johnholland
Thu 23 Apr 2015 17:23
Forum: Lyme Café
Topic: Is Maple Syrup a Potential Biofilm Buster?
Replies: 11
Views: 5584

Re: Is Maple Syrup a Potential Biofilm Buster?

Hi Rita, with such news I'm always wondering: Does it work for borrelia biofilm? Can it have biofilm dispersal activity (not just inhibitory)? Is the concentration reachable in vivo? Does it cross the blood-brain-barrier? Does it have toxicity? There is a lot of diffuse information about anti-biofil...
by johnholland
Mon 13 Apr 2015 19:42
Forum: Lyme Café
Topic: A good lab to test for Lyme in Europe? And ALS/Lyme info?
Replies: 1
Views: 1084

Re: A good lab to test for Lyme in Europe? And ALS/Lyme info

This is one of the most reputable labs that test for lyme/borreliosis. Its in Berlin, Germany.

http://www.imd-berlin.de/spezielle-komp ... liose.html
by johnholland
Mon 2 Mar 2015 12:47
Forum: Unconventional
Topic: Low-frequency ultrasound
Replies: 0
Views: 3768

Low-frequency ultrasound

There is quite some literature on the use of low-frequency ultrasound for bacterial infections (also biofilm related). Anyone tried this? Synergistic bactericidal effects and mechanisms of low intensity ultrasound and antibiotics against bacteria: a review. http://www.ncbi.nlm.nih.gov/pubmed/2215322...
by johnholland
Mon 25 Aug 2014 20:06
Forum: Unconventional
Topic: Intramuscular Colloidal Silver (MRI scans included)
Replies: 3
Views: 10612

Re: Intramuscular Colloidal Silver (MRI scans included)

After using 3 years colloidal silver I have to conclude that it wont cure me. I did improve a lot on it (more than on AB)but its not the solution for me.