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I don't think this study shows what it tries to prove, that Zith passes the BBB well. It doesn't prove that because the subjects had brain tumors so there was a high probability that the BBB was already compromised. You do have a point that the BBB of (some of) these subjects may have been compromi...

J Ocul Pharmacol Ther. 1998 Dec;14(6):575-83. Ocular penetration of oral clarithromycin in humans. * Al-Sibai MB, * Al-Kaff AS, * Raines D, * El-Yazigi A. King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia. Clarithromycin has a wide spectrum of activity against many gram-positive and gram-neg...

Int J Antimicrob Agents. 2001;18 Suppl 1:S11-5. Advanced-generation macrolides: tissue-directed antibiotics. * Amsden GW. The Clinical Pharmacology Research Center, Bassett Healthcare, One Atwell Road, Cooperstown, NY 13326-1394, USA. guy.amsden@bassett.org The azalide antibiotic azithromycin and th...

Arch Ophthalmol. 1998 Dec;116(12):1625-8. Ocular levels of azithromycin. * Tabbara KF, * al-Kharashi SA, * al-Mansouri SM, * al-Omar OM, * Cooper H, * el-Asrar AM, * Foulds G. Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia. OBJECTIVE: To assess azithromy...

Free full text: http://aac.asm.org/cgi/reprint/40/3/825?view=long&pmid=8851625 Antimicrob Agents Chemother. 1996 Mar;40(3):825-6. Distribution of azithromycin into brain tissue, cerebrospinal fluid, and aqueous humor of the eye. * Jaruratanasirikul S, * Hortiwakul R, * Tantisarasart T, * Phuenpathom...