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How can the word "persistent" be used?

Posted: Sun 29 Mar 2015 19:24
by X-member
I give you an example:

Borrelia burgdorferi Changes Its Surface Antigenic Expression in Response to Host Immune Responses

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC517580/

A quote:
The Lyme disease spirochete, Borrelia burgdorferi, causes persistent mammalian infection despite the development of vigorous immune responses against the pathogen.

Re: How can the word "persistent" be used?

Posted: Sun 29 Mar 2015 20:07
by X-member
Another example:

EFNS guidelines on the diagnosis and management of European Lyme neuroborreliosis

http://icnapedia.org/guidelines/open/EF ... liosis.pdf

A quote:
.....late LNB has a chronic* course that probably reflects persistent survival of bacteria in nervous tissue.
late LNB = late Lyme neuroborreliosis

* Information about how the word "chronic" can be used can be found in the thread below:

How can the word "chronic" be used?

http://www.lymeneteurope.org/forum/view ... =11&t=5733

Re: How can the word "persistent" be used?

Posted: Mon 30 Mar 2015 19:56
by X-member
More:

Prolonged antibiotic therapy in PCR confirmed persistent Lyme disease

http://www.grin.com/en/e-book/166179/pr ... me-disease

A quote:
We examined a sample of 90 individuals that had previously received a course of appropriate antibiotics for Lyme disease without experiencing full resolution of their symptoms and had evidence of persistent infection documented by PCR analysis.

Re: How can the word "persistent" be used?

Posted: Wed 1 Apr 2015 15:13
by X-member
It is our belief that the vast majority of chronic bacterial infections are biofilms.
Garth Ehrlich, PhD, has been examining how chronic* infections persist despite of antimicrobial treatment.

Watch his interesting interview:

Dr. Garth Ehrlich - Twenty Years of Biofilm Research

https://www.youtube.com/watch?v=OK-6B2J-si0

* Information about how the word "chronic" can be used can be found in the thread below:

How can the word "chronic" be used?

http://www.lymeneteurope.org/forum/view ... =11&t=5733

Re: How can the word "persistent" be used?

Posted: Sat 2 May 2015 23:34
by X-member
I wrote that persistent Lyme disease/persistent borreliosis also can stand for late Lyme disease in another thread, but I removed it again.

I give you one (more) example in this thread instead.

A (not perfect) google translated quote from the Swedish recommendations (background information):

Dr Johan Berglund:
For late/persistent Lyme infection count more unusual late prominent syndromes engaging joints (Lyme arthritis), skin (acrodermatitis chronica atrophicans) and nervous system.
https://lakemedelsverket.se/upload/hals ... A4rken.pdf

Re: How can the word "persistent" be used?

Posted: Sun 3 May 2015 0:00
by X-member
The word "persistent" is used in two ways (both stands for an active borrelia infection) as you can see in earlier posts in this thread.

But how many patients with any of those two definitions of persistent Lyme disease was included in the study in the thread below?:

Persistent Lyme Empiric Antibiotic Study Europe (PLEASE)

http://www.lymeneteurope.org/forum/view ... f=6&t=3280

A quote:
The purpose of the study is to establish whether prolonged antibiotic treatment of patients diagnosed with proven or presumed PLD* (as endorsed by the international ILADS guidelines) leads to better patient outcome than short-term treatment as endorsed by the Dutch CBO guidelines.
* PLD = persistent Lyme disease

Re: How can the word "persistent" be used?

Posted: Sat 18 Jul 2015 15:00
by X-member
I found this link in the thread below:

http://www.lymeneteurope.org/forum/view ... f=5&t=5863

Laboratory Diagnosis of Lyme Borreliosis
Ivar Tjernberg, Sweden

http://www.diva-portal.org/smash/get/di ... TEXT01.pdf

A quote:

Stage Localisation Time after tick bite Clinical manifestation

I Localised, early, Days to weeks: EM
II Disseminated, Weeks to months: Multiple EM, early BL, LC, LNB
III Persistent, late, Months to years: LA, ACA, Late LNB

Re: How can the word "persistent" be used?

Posted: Fri 11 Sep 2015 16:44
by X-member
The International Lyme and Associated Diseases Society

http://www.ilads.org/lyme/ILADS_Guidelines.pdf

A quote:
Symptoms may continue despite 30 days of treatment (persistent Lyme disease). The patient may relapse in the absence of another tickbite or erythema migrans rash (recurrent Lyme disease), or be poorly responsive to antibiotic treatment (refractory Lyme disease).

Re: How can the word "persistent" be used?

Posted: Fri 25 Mar 2016 15:07
by X-member
Evidence assessments and guideline recommendations in Lyme disease: the clinical management of known tick bites, erythema migrans rashes and persistent disease

ILADS

http://www.tandfonline.com/doi/full/10. ... 014.940900

Re: How can the word "persistent" be used?

Posted: Fri 2 Dec 2016 19:13
by X-member
From the post/thread below:

Ceftriaxone Pulse Dosing Fails to Eradicate Biofilm-Like Bb Persisters

http://www.lymeneteurope.org/forum/view ... =10#p44658

A quote:
But you fail to grasp the main point of all this research, namely, that the work is directed toward find an antibiotic to cure a persistent infection FOR WHICH THERE IS NO EVIDENCE in the first place.
Check the previous posts in this thread!