I've looked over that website, and the Rituximab post about CFS and chronic Lyme and post-sepsis, well I keep trying to wade through the entire piece, but I keep getting distracted..
I think she says that Bb still infecting them, but it isn't the problem; it's the immune suppression triggered by this post-sepsis condition that was caused by OspA. It's EBV and HHV-6 etc viruses that are coming to the fore because of this. The result is ME/CFS, i.e. post-sepsis, which also may be responsible for other conditions/diseases.
Can Lyme result in sepsis? I guess. I don't see why not.
But this is a little different. She is mixing ME/CFS theory with Lyme theory - and many of the inherent controversies in both. The thing is, she is using the Rituximab trials as the pivot point; I'm not sure that works unless she states Bb is gone in each of those patients in the trial. Or unless she knows that Bb is not exacerbated by the Rituximab.
Look. If someone had an acute case - early Lyme - what would happen if they took Rituximab? Might that not be disastrous?
I am still trying to work my way through that website. I read a little, then jump to another thing on it that catches my interest - which leads me to another post on it...It's a mammoth website.
But ME/CFS is a labyrinth. It's tough to navigate that landscape since so much of the theory is just theory. We KNOW the immune system is out of whack - but why? Is there an infection? Is it autoimmune triggered by EBV or Lyme? Is there mito damage involved - if so, how and why did this happen?
There are myriad of other issues.
It's great to say post-sepsis. Symptoms fit. It fits a viral/bacterial etiology. So it's a hypothesis that would be fun to explore.
But the Rituximab throws me if Lyme is still present. Her whole lynch pin may be the weakness to the theory.
Then again, I think some of these trial patients had EBV and HHV-6 titers that suggest re-activation and THOSE didn't worsen after Rituximab...
I think I need a flow chart.
OR maybe just a better appreciation of Rituximab.