Immunomodulatory and antiinflammatory properties of ABX

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Yvonne
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Immunomodulatory and antiinflammatory properties of ABX

Post by Yvonne » Sun 7 Feb 2010 11:34

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Yvonne
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Re: Immunomodulatory and antiinflammatory properties of ABX

Post by Yvonne » Sat 14 Aug 2010 20:15

Tetracyclines inhibit activated B cell function :

http://intimm.oxfordjournals.org/cgi/re ... /7/921.pdf
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Yvonne
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Re: Immunomodulatory and antiinflammatory properties of ABX

Post by Yvonne » Sat 14 Aug 2010 20:16

Med Pregl. 2009 Jul-Aug;62(7-8):327-30.

Immunomodulatory actions of antibiotics

[Article in Serbian]

Minić S, Bojić M, Vukadinov J, Canak G, Fabri M, Bojić I.

Specijalisticka ordinacija "Dr Bojić", Beograd.

Abstract
INTRODUCTION: Antimicrob drugs and immune system interaction has been studied since the pioneer works of Metchnikoff. After the introduction of antibiotics in clinical practice this area has attracted little attention of investigators, because of the lack of standards. This is the reason that the studying of the influence of antibiotics on immune system is still at its beginning.

AIM: To point out the immunomodulatory action of some antibiotics on certain components of immune system.

METHODS AND RESULTS: The literature findings show that antibiotics express immunomodulatory action on some components of immune system such as fagocytes (polymorphonucleary, macrophages, monocytes), cytokines, immunoglobulines, and on cellular immunity. The principles of antibiotics action on phagocyte are the inhibition of chemotaxis and oxidants production. Macrolides applied for a short time enhance the phagocytic functions while their long use leads to immunosupression. Some cephalosporines and rifampicin in therapeutic doses inhibit the oxydative metabolism, of macrophages. Tetracyclines, clindamycines, chloramphenicol and tobramycin inhibit the synthesis of superoxyd anione. The action of some antibiotics on cytokine and specific antibodies is also important. Cellular immunity can be affected as well. After administration of certain antibiotics it takes 1-2 weeks to reestablish normal cellular immunity, and for other even more.

CONCLUSION: There is still no clear standing on real effects of antibiotics on the immune system. Clinicians should search for more information from this new-old field of investigation in order to give more adequate therapy to patients.

PMID: 19902783
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Yvonne
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Re: Immunomodulatory and antiinflammatory properties of ABX

Post by Yvonne » Sat 14 Aug 2010 20:17

Int J Antimicrob Agents. 2001;18 Suppl 1:S89-91.

Non-antimicrobial activities of macrolides.

Williams JD.

University of London, 31 St. Olav's Court, 25 Lower Road, London SE16 2XB, UK. jdw@ischemo.demon.co.uk

Abstract
While using macrolides for the treatment of infectious diseases, some non-microbiological effects have been observed. The stimulation of gastrointestinal motility, which is a common side-effect of macrolides, may be advantageous in patients with poor upper gut motility. Macrolides, as well as directly inhibiting bacterial growth, may exert immunomodulatory effects. Utilisation of these properties may be useful in the treatment of chronic inflammatory conditions, especially if bacterial infection is also implicated. Preliminary evidence also suggests that the currently available macrolide antibiotics possess antitumour activity. In the future, an increased understanding of the structure-activity relationships of macrolides may result in the development of new structurally related compounds that concentrate on these pharmacological properties in addition to, or instead of, antimicrobial activity.

PMID: 11574202
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Re: Immunomodulatory and antiinflammatory properties of ABX

Post by Yvonne » Sat 14 Aug 2010 20:19

J Infect Dis. 2009 May 1;199(9):1379-88.

The antibiotics doxycycline and minocycline inhibit the inflammatory responses to the Lyme disease spirochete Borrelia burgdorferi.

Bernardino AL, Kaushal D, Philipp MT.

Division of Bacteriology and Parasitology, Tulane National Primate Research Center, Tulane University, Covington, LA 70433, USA.

Abstract
Tetracyclines moderate inflammatory responses of various etiologies. We hypothesized that tetracyclines, in addition to their antimicrobial function, could exert control over the inflammation elicited by Borrelia burgdorferi. To model systemic effects, we used the human monocytic cell line THP-1; to model effects in the central nervous system, we used rhesus monkey brain astrocytes and microglia. Cells were stimulated with live or sonicated B. burgdorferi or with the lipoprotein outer surface protein A in the presence of increasing concentrations of doxycycline or minocycline. Both antibiotics significantly reduced the production of tumor necrosis factor-alpha, interleukin (IL)-6, and IL-8 in a dose-dependent manner in all cell types. Microarray analyses of the effect of doxycycline on gene transcription in spirochete-stimulated monocytes revealed that the NFKB and CHUK (alias, IKKA) genes were down-regulated. Functionally, phosphorylation of IkappaBalpha and binding of NF-kappaB to target DNA were both reduced in these cells. Our results suggest that tetracyclines may have a dual therapeutic effect in Lyme disease.

PMID: 19301981
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Re: Immunomodulatory and antiinflammatory properties of ABX

Post by Yvonne » Sat 14 Aug 2010 20:21

Eur J Pharmacol. 2007 Dec 8;576(1-3):171-9. Epub 2007 Jul 31.

Characterization of the antinociceptive and anti-inflammatory activities of doxycycline and minocycline in different experimental models.

Bastos LF, Merlo LA, Rocha LT, Coelho MM.

Faculdade de Farmácia, Universidade Federal de Minas Gerais, Avenida Antônio Carlos 6627, 31270-901, Belo Horizonte, MG, Brasil.

Abstract
Tetracyclines induce anti-inflammatory effects unrelated to their antimicrobial activities. We investigated the effect induced by minocycline and doxycycline in models of nociceptive and inflammatory pain, edema, fever, cell migration and formation of fibrovascular tissue, as these effects have not been fully investigated. Tetracyclines were administered via intraperitoneal route 1 h before the tests. Minocycline and doxycycline (100 mg/kg) inhibited the second phase of the formalin-induced nociceptive response in mice. Doxycycline (100 mg/kg) also inhibited the first phase. The nociceptive response induced by phorbol 12,13-didecanoate (PDD) in mice was inhibited by doxycycline (100 mg/kg). Furthermore, carrageenan-induced mechanical allodynia in rats was inhibited by doxycycline and minocycline (50 or 100 mg/kg). However, they did not enhance the latency in the hot-plate test. It is unlikely that antinociception resulted from motor incoordination or muscle relaxing effect, as both tetracyclines (100 mg/kg) did not impair the motor activity of mice in the rota-rod test. Doxycycline (50 or 100 mg/kg) or minocycline (50 or 100 mg/kg) inhibited carrageenan-induced paw edema in rats. However, only minocycline (100 mg/kg) inhibited PDD-induced edema. Carrageenan-induced leukocyte migration into the peritoneal cavity of rats was inhibited by both tetracyclines (100 mg/kg). Endotoxin-induced fever in rats was also inhibited by doxycycline (50 or 100 mg/kg) or minocycline (100 mg/kg). Finally, formation of fibrovascular tissue induced by subcutaneous implant of a cotton pellet in mice was inhibited by a 6-day administration of both tetracyclines (50 or 100 mg/kg day). Concluding, this study clearly shows the antinociceptive and anti-inflammatory activities of these second-generation tetracyclines.

PMID: 17719028
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Yvonne
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Re: Immunomodulatory and antiinflammatory properties of ABX

Post by Yvonne » Sat 14 Aug 2010 20:22

Cutis. 2005 Apr;75(4 Suppl):6-11.

The anti-inflammatory effects of tetracyclines.

Weinberg JM.

Clinical Research Center, Department of Dermatology, St Luke's-Roosevelt Hospital Center, New York, New York, USA.

Abstract
Tetracyclines commonly are used in medicine and dentistry because of their efficacy and safety as bacteriostatic antimicrobial agents. As such, tetracyclines function by inhibiting bacterial multiplication and growth. In addition to these effects, tetracyclines have anti-inflammatory properties and have been shown to exhibit several intracellular and extracellular biologic effects that are not related to antibiotic activity. These activities correlate with anti-inflammatory and anticollagenolytic properties. This article will review the anti-inflammatory properties of the tetracyclines and the various clinical applications related to these actions. In addition, the use of subantimicrobial dose doxycycline 20 mg twice a day (SDD) will be discussed because of its anti-inflammatory effects.

PMID: 15916224
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