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Doxycycline and smell and taste disorders

Posted: Sun 4 Apr 2010 9:50
by Yvonne

Re: Doxycycline and smell and taste disorders

Posted: Tue 6 Apr 2010 3:39
by rlstanley
http://www.lareb.nl/documents/kwb_2009_4_doxyc.pdf
Discussion and Conclusion

Doxycycline is commonly used in the treatment of upper respiratory tract infection. The infection
itself could also cause reduction in smell and taste. In a spontaneous reporting system a
pharmacovigilance centre is dependent on reports made of ADRs. Even though there is a
possibility of confounding by indication, 36 reports of smell and taste disorders, significantly more
often reported in the Lareb and WHO database, except for dysgeusia/taste perversion, is
indicative for a signal, even though the causality of the individual cases themselves are not.
Besides, in three of the reports the indication was Lyme disease which is not associated with
smell and taste disorders.

Other possible confounding factors include the co-medication. A few
patients also used other drugs such as corticosteroids (oral or nasal spray) or metronidazole
which are also known to induce smell and taste disorders [7]. Levothryroxine and hypothyroidism
are also associated with smell and taste disorders.

The Netherlands Pharmacovigilance Centre Lareb has received 36 reports concerning smell
and/or taste disorders related to the use of doxycycline. The majority of the reports concern
female patients (n=29). This association is disproportionally present in both the Lareb as well as
the WHO database except for dysgeusia/taste perversion Information about this association in
literature is limited to one case report.

Possible mechanism for this ADR include interference with
binding of tastants and odorants to their specific receptor, alterations of the oral, gastric and
intestinal flora which can lead to superimposed infections (e.g. candidiasis, caries) and
periodontal disease and the fact some anti-bacterials taste bitter, metallic and/or sour at
concentrations that occur in salivary secretion.

Re: Doxycycline and smell and taste disorders

Posted: Tue 6 Apr 2010 7:00
by Fin24
I wonder how the other 'cyclines stack up--with this particular possible side effect??

Re: Doxycycline and smell and taste disorders

Posted: Tue 6 Apr 2010 9:30
by Yvonne
I don't know. I'll look of I can find something about it.

Re: Doxycycline and smell and taste disorders

Posted: Tue 6 Apr 2010 17:48
by Cobwebby
My smell and taste went wonko when I was given IV Levaquin.Took about three weeks to resolve back to my norm.

Re: Doxycycline and smell and taste disorders

Posted: Tue 6 Apr 2010 20:49
by Fin24
since this was about doxy, other 'cyclines would be chemically related
by Cobwebby ยป Tue 6 Apr 2010 16:48

My smell and taste went wonko when I was given IV Levaquin.Took about three weeks to resolve back to my norm
while its unfortunate that Cobs had taste perversions on levoquin thats not really pertinent since that drug is way different in action, effects and chemistry

thanks Yvonne--if you can find anything

I already know the 'cyclines can affect hearing and tinnitus and aural nerves both peripheral and central(brain) and they can raise CSF making Chiari pts more likely to be intolerant. Itd be interesting to see if the other cyclines share this taste perversion propensity. smell and/or taste usually means sensory nerves and that would be same or similar for aural/hearing nerves.

Yvonne--hope all is well at your home/family!!! and enjoying spring!!