Ocular levels of azithromycin

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Ocular levels of azithromycin

Post by Martian » Thu 26 Jul 2007 18:47

Arch Ophthalmol. 1998 Dec;116(12):1625-8.

Ocular levels of azithromycin.

* Tabbara KF,
* al-Kharashi SA,
* al-Mansouri SM,
* al-Omar OM,
* Cooper H,
* el-Asrar AM,
* Foulds G.

Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

OBJECTIVE: To assess azithromycin levels in human serum, aqueous humor, tear fluid, and conjunctival tissue specimens after administration of a single 1-g oral dose of azithromycin.

METHODS: Sixty patients undergoing cataract surgery were included in this analysis. Serum, aqueous, and tear specimens were collected 3, 6, and 12 hours and 1, 2, 3, and 4 days after azithromycin administration. Conjunctival tissue biopsy specimens were collected 1, 2, 3, 4, 6, 8, 10, 12, and 14 days after azithromycin administration. All specimens were subjected to analysis by high-performance liquid chromatography-mass spectrometry.

RESULTS: Azithromycin concentration ranges during the specified sampling times were as follows: serum, 21 to 974 ng/mL; tear, 82 to 2892 ng/mL; aqueous, 10 to 69 ng/mL; and conjunctival, 0.7 to 32 micrograms/g. Levels above the 90% minimal inhibitory concentration (MIC90) for Chlamydia trachomatis were detected after 4 days in all tear samples and after 14 days in all conjunctival tissue specimens following oral azithromycin administration.

CONCLUSION: We demonstrated prolonged high levels of azithromycin in drug-targeted ocular tissue. Prolonged high concentrations of azithromycin in conjunctival tissue make this drug suitable for treatment of conjunctivitis caused by chlamydiae and other susceptible organisms.

PMID: 9869792 [PubMed - indexed for MEDLINE]

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Re: Ocular levels of azithromycin

Post by cave76 » Wed 1 Apr 2009 15:22


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