Blebs / vesicles of borrelia - ?weapons or ?Flotsam Jetsam?

Topics with information and discussion about published studies related to Lyme disease and other tick-borne diseases.
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inmacdonald
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Blebs / vesicles of borrelia - ?weapons or ?Flotsam Jetsam?

Post by inmacdonald » Sun 22 Jan 2012 1:38

Hello to Members of the forum:

I submit this a a point of departure concerning Borrelia "Blebs / Vesicles"

The attachment displays the formation of "Blebs" / "vesicles" of borrelia
during the event of Cyst formation from a magnificent paper by
Drs Albna, Johnson, and Nelson:

See attachments below:


**********************************************************************************************************************************
Note: The diameter of the Cyst greatly exceeds the diameter of the Blebs.
In this image the Blebs show a configuration of a "string of Pearls" which is
a descriptive term which I suggested to scientists at the Rocky Mountain Lab
who were the very first to "see" the ultrastructure of "blebs" of borrelia burdorferi
under Electron Microscopy. (Note:" String of Pearls "is a Jazz Standard, hence my
choice of this term)
Attachments
alban diagran.pdf
Alban diagram Annoted "Blebs"
(48.43 KiB) Downloaded 325 times
Alban diagram A B C.pdf
Alban et al Figure 1
(114.33 KiB) Downloaded 317 times

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inmacdonald
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Re: Blebs / vesicles of borrelia - ?weapons or ?Flotsam Jets

Post by inmacdonald » Sun 22 Jan 2012 22:38

Blebs ( vesicles) of Borrelia burgdorferi , detached from spiral forms, are abundant on the
grid. Due to the very small size of the blebs (vesicles) they are virtually "invisible"
in ordinary laboratory ,microscopes. Scanning Electron Microscopy was used th visualize
the blebs ( see arrows in the image)
Image from the website of the New York State Department of Health, Wadsworth Laoratory.
Attachments
New York State Department of Health Borrelia annotated.pdf
Abundant detached borrelia blebs (vesicles)
(96.37 KiB) Downloaded 274 times

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inmacdonald
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Re: Blebs / vesicles of borrelia - ?weapons or ?Flotsam Jets

Post by inmacdonald » Sun 22 Jan 2012 23:23

MYRIAD BLEBS (VESICLES) ARE PRESENT IN THE GUT OF THE FEEDING TICK[/color


With this image in view it is sobering to note that Blebs (vesicles)
which are invisible under the ordinary laboratory microscope,
Vastly outnumber intact spiral forms of Borrelia burgdorferi
at time time of the tick bite.

These Blebs contain an ouiter surface membrane compoonent Osp A, Osp B, Osp D
and other epitopes
Additional "Cargo" inside the Blebs (vesicles) includes intact minichromosomes
(circular and linear palsmids).
A "biologic multiplier" effect is the consequence of a single infectious spiral
borrelia which is accompanied by .....MYRIAD Blebs (vesicles)
Attachments
Myriad blebs of Borrelia burgdorferi in the tick (blebs in green).pdf
Myriad borrelia Blebs (in green GFP) shown in gut of feeding tick
(81.69 KiB) Downloaded 258 times

X-member
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Re: Blebs / vesicles of borrelia - ?weapons or ?Flotsam Jets

Post by X-member » Mon 23 Jan 2012 21:25

Very interesting! Thank you!

Will Wiegman
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Re: Blebs / vesicles of borrelia - ?weapons or ?Flotsam Jets

Post by Will Wiegman » Sun 7 Jul 2013 6:59

The 'blebs' have in fact been proven to contain both DNA and a looped portion of m-RNA. It seems they end up in the Islets of Langerhans and cause Type I diabetes and pancreatic cancers.

http://cancerres.aacrjournals.org/conte ... 8.abstract

A reverse vaccine has been produced to counteract the effects of the m-RNA.

http://articles.latimes.com/2013/jun/28 ... e-20130627

In pancreatic cancer, the blebs produce an outburst of new spirochetes which swarm the newly divided cancer cells, collecting excess insulin from them.

http://www.medgadget.com/2008/08/chemop ... tment.html

Initially, newly divided pancreatic cells are 'clean' on their surface.

http://www.sciencephoto.com/media/254408/view

Antibodies attack the Islets of Langerhans in pancreatic tissues looking for the blebs.

http://news.sciencemag.org/scienceinsid ... -drug.html

The looped m-RNA could be fabricated creating a strain of Borrelia with detrimental qualities over and above it's normal capabilities.

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inmacdonald
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Re: Blebs / vesicles of borrelia - ?weapons or ?Flotsam Jets

Post by inmacdonald » Sun 7 Jul 2013 14:42

LIPOSOMES -- THE CORRECT SCIENTIFIC NAME FOR "BLEbs

Liposome is the scientific name for the "blebs" which emanate from theouter surface
membrane of Borrelia species as the spiral microbes move through tissues and body fluids.

It is , at first glance, astonishing, that any DNA or MRna at all would be found
in the space between the outer surface membrane region and the cylindrical cell wall.
One would predict that DNA
"Belongs" INSIDE of the CELL Wall Cylindrical region of the spirochete.

After all, the Cell Wall Cylinder region of the spirochete is Rigid, protective, and persists even after
the Outer Surface Membrane "Outer cylinder" has been stripped away by washing the spirochetes
in phosphate buffered saline. The Outer surface membrane is "slime" , moveable, and relatively
fragile, when Compared with the Cell wall invested Inner cylinder compartment.
The Cell Wall is the Protective Wrapper for all of the Guts of the spirochete.

Be that as it may, Nature has its own set of rules.
The Outer surface membrane "cylinder region" contains its own DNA and RNA.

Bleb like bodies [Liposomes] regularly "pinch off" from the outer surface membrane cylinder and
these Liposomes contain DNA and Rna as demonstrated by Dr Claude Garon by Transmission
Electronmicroscopy study. Individual moleclues of actual Circular DNA and Linear DNA were photographed
in his classcial article in Scanning Electron Microscopy journal ( supplement 0 in 1988.

There appears to be NO LIMIT to the number of blebs which can be shed by a living borrelia
during its lifetime, and no decrement in the the total DNA composition of the bleb shedding
Borrelia as they "shed their blebs" as they move through tissues.

This Bleb shedding during lifetime of the spirochete is a Biological Multiplier.

The Free blebs have been photographed in high density at the tick bite site
{Beerman et al} and have been tracked as the Bleb/liposomes fuse with the cell membranes of living
human lymphocytes, neurons, and other non-phagocytic cells. After fusion of the Bleb/ liposomes
with the mammalian cell membrane, the Bleb/liposomes enter the mammalian cytoplasm.
The Internalized cytoplasmic bleb/liposomes then move across the cytoplasm to
fuse with the Nuclear membrane. Penetration of the mammalian cell nucleoplasm by 'borrelia
bleb/liposomes enables the release of Borrelia DNA and Rna contained within the blebs
with the Nucleoplasm and direct access to Mammalian DNa.
Liposomes are a tool for the TRANSFECTION of Mammalian DNA.
[Commercially available kits available for purchase to induce laboratory TRANSFECTION
of mammalian cells.
Internalized Bleb DNa is free within the nucleoplasm to TRANSFECT Human DNA.
Transfection is a Permanent Chemical incorporation of DNA of one species {ie Borrelia}
with the DNA of another species { ie Human}. Borrelia DNA contains Covalently linked ends.
Human DNA has Covalently linked ends .
After TRANSFECTION, the Borrelia DNA has a permanent place in the TRANSFECTED cell
DNA content. Consequences of such a transfection are enormous. Mutation of human DNA,
Borrelia DNA transcription of its DNA, now resident inside a human cell, and movement of
borrelia directed proteins to the cell surface of the Transfected human cells.
Borrelia proteins which are chemically incorporated into the cell membranes of human cells
would provoke an immune response against the Transfected human cells.
Auto-immunity is thereby explained. Autoimmunity in Borrelia infections has long been noted
by Dr. Allen Steere. But Dr. Allen Steere has no scientific explanation for the reason that
Autoimmunity would actually develop as a result of borrelia infection.

Bleb [liposome] mediated Transfection provides the answer to Autoimmune events in
borreliosis.

Alan B.MacDonald MD
July 7, 2013

Pandora
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Re: Blebs / vesicles of borrelia - ?weapons or ?Flotsam Jets

Post by Pandora » Sun 7 Jul 2013 19:50

GREAT POST!!! Thank You!!!

Visual detection of prion protein based on color complementarity principle.
http://www.ncbi.nlm.nih.gov/pubmed/23827372
Biosens Bioelectron. 2013 Jun 18;50C:14-18. doi: 10.1016/j.bios.2013.06.014. [Epub ahead of print]

New concept of spectrum. Another new concept. Produce an exit of spirochetal disease out of the skin to say pos except in the most severe immune compromised. Which may require an antibiotic challenge. A tube of animal wormer paste or even Stevia plant based antibiotics, or any form of mild acid such as lemon will produce an exit.
http://www.morgellons-research.org/morg ... oscop3.htm

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inmacdonald
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Re: Blebs / vesicles of borrelia - ?weapons or ?Flotsam Jets

Post by inmacdonald » Sun 7 Jul 2013 20:20

In the continuation of discussion of methods to RELEASE pathogens...

A gift from Dr Bill Costerton:

[full interview with Dr Bill Costerton is posted and freely available on You tube]

Dr. Costerton, in one of his last recorded interviews before his death in 2012
describes Exciting new observations on the In Vitro
experiments which demonstrated that ULTRASOUND Energy
Delivered to Biofilm communities grown in Test tubes
DISRUPTED the Biofilm communities
by the mechanism of Ultrasound induced formation of
gas bubbles which disrupted the Extracellular matrix which
normally invests and protects the members of the biofilm community
from assault by antibiotics and other hostile elements.
Ultrasound in effect creates an electromagnetic "saponification-like"
condition which releases the individual specialized microbes
from the protective niche of the biofilm and which then enables
antibiotics to kill the microbes.

Ultrasound energy of specific power might enable IN VIVO biofilm
communities to be disrupted and pave the way for their elimination.

Another piece in the Puzzle of How to penetrate the impenetrable
and Release the microbes from their protective wrapper.
A PubMed search will retrieve many articles on Ultrasound disruption of
biofilms of Staphylocccus and Pseudomonas and other microbial species.

Electromagnetic energy in service to humanity,
with no toxicity!



Alan B.MacDonald. MD
July 7, 2013

Pandora
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Re: Blebs / vesicles of borrelia - ?weapons or ?Flotsam Jets

Post by Pandora » Tue 9 Jul 2013 20:42

http://en.wikipedia.org/wiki/Tick-borne ... itis_virus

Together with his colleagues he discovered the etiology of a new transmissible neurological disease called tick-borne encephalitis (TBE)

and isolated the virus that causes it.

He was accidentally infected with the virus and developed encephalitis that led to a permanent loss of hearing and paralysis of the right arm.

For this discovery he was awarded Stalin Prize of First Degree in Science and Technology in 1941. In 1948 Chumakov became a corresponding member, and in 1960 a full member of Academy of Medical Sciences of the USSR. Beginning in the 1940s Chumakov organized multiple medical expeditions to Siberia and other regions of the Soviet Union to investigate outbreaks caused by new viruses.

Among viruses discovered and studied by Chumakov are Omsk hemorrhagic fever and Kemerovo fever viruses,hantavirus causing renal syndrome, Crimean-Congo Hemorrhagic Fever virus, and many others. From 1950 he was the Director of the Ivanovsky Institute of Virology in Moscow. In 1955 he organized a new research institute near Moscow to work on vaccines against poliomyelitis. His work on vaccines against poliomyelitis was done in close collaboration with American scientists including Jonas Salk and Albert Sabin. In 1958-1959 he organized the first mass production and clinical trials of Oral Poliovirus Vaccine (OPV) made from live attenuated strains developed by Albert Sabin.,.
--
Wonder if they knew back then spirochetal prion proteins could not be killed or decontaminated? I know its highly contradictory---But....would feeding spirochetes something to get them into more spirochetal forms have much more killing effects than trying to hit the cyst forms? I guess what I'm asking is---can you give them all the sugars/cholesterol they want and kill them easier than starving them into latency, and then trying to kill them ?

Margherita
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Re: Blebs / vesicles of borrelia - ?weapons or ?Flotsam Jets

Post by Margherita » Fri 12 Jul 2013 17:25

Dear Dr. McDonald,

Thank you very much for this interesting subject and clear explanation.
After TRANSFECTION, the Borrelia DNA has a permanent place in the TRANSFECTED cell
DNA content. Consequences of such a transfection are enormous. Mutation of human DNA,
Borrelia DNA transcription of its DNA, now resident inside a human cell, and movement of
borrelia directed proteins to the cell surface of the Transfected human cells.
Borrelia proteins which are chemically incorporated into the cell membranes of human cells
would provoke an immune response against the Transfected human cells.
Auto-immunity is thereby explained
So the more spirochetes are present in a human body or the longer one is dealing with borrelia, the higher is the immune response. Could this be one of the reasons why many patients are not recovering although they were prescribed long term antibiotics and/or are erroneously told they are suffering from post lyme syndrome?

Furthermore, could there be a connection between specific antibodies such as for instance P-Anca's and the immune response caused by borrelia lipofection? (it seems p-Anca antibodies are associated among others with Rheumatoid arthritis and vasculitis)

http://en.wikipedia.org/wiki/P-ANCA
Last edited by Margherita on Fri 12 Jul 2013 17:55, edited 1 time in total.

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