Can someone direct me to a paper which examines the insignificance of the fact that B. burgdorferi is able to internalize into different eukaryotic cells, including endothelial cells, fibroblasts, neuronal, and neuroglial cells as reported by the following papers.Most patients were treated with courses of intracellular-penetrating antibiotics, either tetracycline itself, 1500 mg/d, or the combination of clarithromycin (1000 mg/d) and hydroxychloroquine (400 mg/d) over at least a 3-month period, usually 6 monthsVa regimen that seems to result in resolution of sustainable improvement in patient symptoms.
[2 Donta refs and still ignoring the fact that B. burgdorferi is not an intracellular pathogen].
Dorward, D. W., E. R. Fischer, and D. M. Brooks. 1997. Invasion and cytopathic killing of human lymphocytes by spirochetes causing Lyme disease. Clin. Infect. Dis. 25(Suppl.1):S2-S8.
Invasion of human skin fibroblasts by the Lyme disease spirochete, Borrelia burgdorferi.
Klempner MS, Noring R, Rogers RA.
Invasion of human neuronal and glial cells by an infectious strain of Borrelia burgdorferi.
Livengood JA, Gilmore RD Jr.
Intracellular localization of Borrelia burgdorferi within human endothelial cells.
Ma Y, Sturrock A, Weis JJ.
Invasion of Eukaryotic Cells by Borrelia burgdorferi Requires β1 Integrins and Src Kinase Activity ‡
Jing Wu,1 Eric H. Weening,1,† Jennifer B. Faske,1,§ Magnus Höök,2 and Jon T. Skare1,*
P. Brouqui, S. Badiaga, D. Raoult: Eucaryotic Cells Protect Borrelia burgdorferi from the Action of Penicillin and Ceftriaxone but Not from the Action of Doxycycline and Erythromycin