Bb & tick proteins re pathogen persistence in vector

Topics with information and discussion about published studies related to Lyme disease and other tick-borne diseases.
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RitaA
Posts: 2768
Joined: Thu 1 Jul 2010 8:33

Bb & tick proteins re pathogen persistence in vector

Post by RitaA » Fri 21 Dec 2012 21:58

Does anyone here have access to the full article? It requires either a subscription or a single article purchase.

http://www.futuremedicine.com/doi/abs/1 ... fmb.12.121
Summary

Future Microbiology

January 2013, Vol. 8, No. 1, Pages 41-56 , DOI 10.2217/fmb.12.121

(doi:10.2217/fmb.12.121)

Review

Borrelia burgdorferi and tick proteins supporting pathogen persistence in the vector

Faith Kung1, Juan Anguita2,3 & Utpal Pal*1

* Author for correspondence

Borrelia burgdorferi, a pathogen transmitted by Ixodes ticks, is responsible for a prevalent illness known as Lyme disease, and a vaccine for human use is unavailable. Recently, genome sequences of several B. burgdorferi strains and Ixodes scapularis ticks have been determined. In addition, remarkable progress has been made in developing molecular genetic tools to study the pathogen and vector, including their intricate relationship. These developments are helping unravel the mechanisms by which Lyme disease pathogens survive in a complex enzootic infection cycle. Notable discoveries have already contributed to understanding the spirochete gene regulation accounting for the temporal and spatial expression of B. burgdorferi genes during distinct phases of the lifecycle. A number of pathogen and vector gene products have also been identified that contribute to microbial virulence and/or persistence. These research directions will enrich our knowledge of vector-borne infections and contribute towards the development of preventative strategies against Lyme disease.

dorothy de kok
Posts: 64
Joined: Fri 2 Nov 2012 15:03

Re: Bb & tick proteins re pathogen persistence in vector

Post by dorothy de kok » Sat 22 Dec 2012 9:12

Future Microbiology

January 2013, Vol. 8, No. 1, Pages 41-56 , DOI 10.2217/fmb.12.121
Give it a couple of weeks and it will have 'leaked' out all over the web. :)

RitaA
Posts: 2768
Joined: Thu 1 Jul 2010 8:33

Re: Bb & tick proteins re pathogen persistence in vector

Post by RitaA » Sat 22 Dec 2012 10:01

Thanks, Dorothy. Good point. :)

Lorima
Posts: 914
Joined: Mon 29 Oct 2007 20:47

Re: Bb & tick proteins re pathogen persistence in vector

Post by Lorima » Sat 22 Dec 2012 16:30

Author info:

Kung F, Anguita J, Pal U.
Source
Department of Veterinary Medicine & Virginia-Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, MD 20742, USA.
"I have to understand the world, you see."
Richard Feynman

RitaA
Posts: 2768
Joined: Thu 1 Jul 2010 8:33

Re: Bb & tick proteins re pathogen persistence in vector

Post by RitaA » Wed 13 Mar 2013 22:42

The full article is now available here for anyone with a (free) Medscape membership:

http://www.medscape.com/viewarticle/776862
Future Microbiology

Borrelia burgdorferi and Tick Proteins Supporting Pathogen Persistence in the Vector

Faith Kung, Juan Anguita, Utpal Pal

Future Microbiol. 2013;8(1):41-56.
It looks like an interesting article so far, with 217 references, but it's important to keep this in mind:
B. burgdorferi Proteins Supporting Pathogen Persistence

In the following sections is a summary of studies that have examined the roles of specific B. burgdorferi plasmids or individual proteins in spirochete infection of the tick vector. All plasmid names are given in reference to B31. Other strains carry varied genomes of differing plasmid contents.

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