Spirochetal lipoproteins and the immune system

Topics with information and discussion about published studies related to Lyme disease and other tick-borne diseases.
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dlf
Posts: 294
Joined: Sun 7 Apr 2013 15:36

Spirochetal lipoproteins and the immune system

Post by dlf » Wed 30 Jul 2014 23:31

My thanks to Campother for posting this on his Twitter site!

http://journal.frontiersin.org/Journal/ ... 0/abstract

The full text PDF is available from the abstract link.
The cross-talk between spirochetal lipoproteins and immunity
imageTheodoros Kelesidis*
Division of Infectious Diseases, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA

Abstract
Spirochetal diseases such as syphilis, Lyme disease, and leptospirosis are major threats to public health. However, the immunopathogenesis of these diseases has not been fully elucidated. Spirochetes interact with the host through various structural components such as lipopolysaccharides (LPS), surface lipoproteins, and glycolipids. Although spirochetal antigens such as LPS and glycolipids may contribute to the inflammatory response during spirochetal infections, spirochetes such as Treponema pallidum and Borrelia burgdorferi lack LPS. Lipoproteins are most abundant proteins that are expressed in all spirochetes and often determine how spirochetes interact with their environment. Lipoproteins are pro-inflammatory, may regulate responses from both innate and adaptive immunity and enable the spirochetes to adhere to the host or the tick midgut or to evade the immune system. However, most of the spirochetal lipoproteins have unknown function. Herein, the immunomodulatory effects of spirochetal lipoproteins are reviewed and are grouped into two main categories: effects related to immune evasion and effects related to immune activation. Understanding lipoprotein-induced immunomodulation will aid in elucidating innate immunopathogenesis processes and subsequent adaptive mechanisms potentially relevant to spirochetal disease vaccine development and to inflammatory events associated with spirochetal diseases.

velvetmagnetta
Posts: 469
Joined: Sun 23 Feb 2014 22:47

Re: Spirochetal lipoproteins and the immune system

Post by velvetmagnetta » Thu 31 Jul 2014 0:08

Wow. Thank you for this, dif and Camp Other!

I am so grateful. As I know others are as well who cannot post.

I love Lymenet Europe!

Pandora
Posts: 252
Joined: Tue 20 Mar 2012 14:58

Re: Spirochetal lipoproteins and the immune system

Post by Pandora » Mon 4 Aug 2014 17:56

Well it won't come in any form of vaccine.....

http://www.ncbi.nlm.nih.gov/pubmed/25075784
Mem Inst Oswaldo Cruz. 2014 Jul;109(4):459-65.
Sympathetic glial cells and macrophages develop different responses to Trypanosoma cruzi infection or lipopolysaccharide stimulation.
Almeida-Leite CM1, Silva IC2, Galvão LM3, Arantes RM2.
Author information
Abstract
Nitric oxide (NO) participates in neuronal lesions in the digestive form of Chagas disease and the proximity of parasitised glial cells and neurons in damaged myenteric ganglia is a frequent finding.

Glial cells have crucial roles in many neuropathological situations and are potential sources of NO.

Here, we investigate peripheral glial cell response to Trypanosoma cruzi infection to clarify the role of these cells

in the neuronal lesion pathogenesis of Chagas disease. We used primary glial cell cultures from superior cervical ganglion to investigate cell activation and NO production
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after T. cruzi infection or lipopolysaccharide (LPS) exposure in comparison to peritoneal macrophages.

T. cruzi infection was greater in glial cells, despite similar levels of NO production in both cell types.

Glial cells responded similarly to T. cruzi and LPS,

but were less responsive to LPS than macrophages were.
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Our observations contribute to the understanding of Chagas disease pathogenesis, as based on the high susceptibility of autonomic glial cells to T. cruzi infection with subsequent NO production. Moreover, our findings will facilitate future research into the immune responses and activation mechanisms of peripheral glial cells, which are important for understanding the paradoxical responses of this cell type in neuronal lesions and neuroprotection.
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Brazil agree's!
MOLECULAR IDENTIFICATION OF Bartonella henselae IN A SERONEGATIVE CAT SCRATCH DISEASE PATIENT WITH AIDS IN RIO DE JANEIRO, BRAZIL.
http://www.ncbi.nlm.nih.gov/pubmed/25076441

Just so you know. T.cruzi behaves antigenically the exact same as Borrelia. They are immune suppressors. Stealth.
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Bottom Line: They turn off the TLR'S TO CAUSE IMMUNE SUPPRESSION TO CAUSE MULTIPLE CHRONIC INFECTIONS TO CAUSE DISABILITY AND DEATH.
http://www.actionlyme.org/101016.htm

IMMUNE SUPPRESSION IS THE NAME OF THE GAME. ALWAYS WAS--ALWAYS WILL BE.

velvetmagnetta
Posts: 469
Joined: Sun 23 Feb 2014 22:47

Re: Spirochetal lipoproteins and the immune system

Post by velvetmagnetta » Mon 4 Aug 2014 23:21

Pandora -

I've read a lot of people referring to Lyme as an immune-suppressive disease lately, and I had the opposite impression. I thought Lyme over-activated the immune system in a general sense - and the problem comes in when the immune system is trying to specify for Lyme antigens.

I was under the impression this was one of our biggest problems - that the immune system is over-reacting and causing us a lot of misery by making us feel like we have a constant flu - fevers, fatigue, muscle aches, etc.

Pandora
Posts: 252
Joined: Tue 20 Mar 2012 14:58

Re: Spirochetal lipoproteins and the immune system

Post by Pandora » Sun 10 Aug 2014 4:03

Lyme is Epstein Barr. Any kind of immune response will activate it. Those tests are criminal too.

Whether it be changes in temp., PH, stress, electromechanically or from blast injury.

Over 95% of the pops are known to be infected. So once activated if you use a Antibody test to determine pos. for chronic infections you most likely will not make the mark.

And a machine says your fat infected cells look great so the public is left with syndromes in failures to find and treat the infections.

How can so many have heart symptoms from Borrelia and T.cruzi and not get treated sooner for the cause? Immune suppression.

How can Downs syndrome sufferers have so much facial deformity from the infections and still not kill them? Immune suppression.

How can MS and CFS pts.survive so long without real treatment for the cause? Immune Suppression.

We are all immune suppressed because we all have Epstein Borreliosis. There is NO MORE NORMAL except in those few people who never had a vaccine for generations of any kind. THOSE are the people who could one day save us all if they were smart enough to save any...

velvetmagnetta
Posts: 469
Joined: Sun 23 Feb 2014 22:47

Re: Spirochetal lipoproteins and the immune system

Post by velvetmagnetta » Mon 11 Aug 2014 13:52

From the article abstract:
Lipoproteins are pro-inflammatory, may regulate responses from both innate and adaptive immunity and enable the spirochetes to adhere to the host or the tick midgut or to evade the immune system. However, most of the spirochetal lipoproteins have unknown function. Herein, the immunomodulatory effects of spirochetal lipoproteins are reviewed and are grouped into two main categories: effects related to immune evasion and effects related to immune activation.
Pandora - What is the difference between "immuno-modulatory" and "immuno-suppressant"?

To me, it sounds like this article is saying that Bb can both evade the immune system as well as activate it. If the immune system was suppressed, then this wouldn't happen.

It looks like 90% of the population is infected with EBV and that may very well act to suppress the immune system - I don't know much about EBV - but Bb is proving to be much more intricate. Bb seems to actually be communicating with the immune system and possibly directing its action.

I think this is what this big computer program the article talks about is trying to find out. I swear, we have the most interesting disease on the planet!

Pandora
Posts: 252
Joined: Tue 20 Mar 2012 14:58

Re: Spirochetal lipoproteins and the immune system

Post by Pandora » Tue 12 Aug 2014 20:04

We have immune systems they didn't even know about until a few yr.s ago. TLR's can actually regulate gene expression!

Discovery and Development of Toll-Like Receptor 4 (TLR4) Antagonists: A New Paradigm for Treating Sepsis and Other Diseases
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2469272/

Systematic Discovery of TLR Signaling Components Delineates Viral-Sensing Circuits
http://www.sciencedirect.com/science/ar ... 7411012700

http://en.wikipedia.org/wiki/TLR_5
TLR5 recognizes flagellin.[3] Flagellin is the protein monomer that makes up the filament of bacterial flagella, found on nearly all motile bacteria. There are highly conserved regions in the flagellin protein among all bacteria, facilitating the recognition of flagellin by a germ-line encoded receptor such as TLR5.[4]
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Yes when latent infections are activated you get a immune response such as that seen in vaccine antigen induced immune responses that are quickly inactivated in depressed immune systems.

Vaccines are actually giving us the very infections they are pretending to prevent in stealth bacterial prion proteins recombinations to evade the immune systems.

And we now have Pertussis strains bearing no vaccine pertactin.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2922045/
In this review we discuss approaches that enhance the activity of APC such dendritic cells (DC). DC are the most potent APC and function to activate innate (e.g. natural killer cells (NK)), and adaptive immune responses which are mediated by B cells and T cells (Figure 1). Both innate and adaptive arms of the immune system are key for recognizing and eliminating tumor cells.
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Which is kinda hard to do since we already have chronically infected B cells of Epstein Borreliosis....
http://www.lymeneteurope.org/forum/view ... 7&start=20

IMO the only way we will stop our age of syndromes is with treatment to kill all the infections in immune suppression and then our own stem cells to activate depressed immune systems and hopefully prevent fetal transmissions.

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