Re: Evolution of Human B Cell Responses to Bb VlsE Protein from Early to Late Stages of Lyme Disease
Posted: Thu 3 Mar 2016 4:05
That could maybe help explain why my immunologist says half of his CVID patients have chronic Lyme infections. Lyme is very common, so it would just be a matter of time before those with CVID or other PIDs would run into it and get stuck.LHCTom wrote:The subclass deficiency would contribute to less effective spirochete ( or bacterial and viral in general) killing off. If both the innate/cellular immune system is blunted and infectious Ab production lowered, that may be an aquired form of immune suppresion that inhibits the killing off of the last viral or bacterial cell enabling persistence. Throw in a few spirochete persisters and we are off to the races - over and over and over.... Is correcting the Th1/Th2 balance part of the problem? Plus correcting the IgG1/3 deficiency? Just a crazy thought.
Now only if someone could prove whether or not Lyme also causes Ig deficiencies, so we'd know if it was the chicken or the egg that started it. Or perhaps one of the other tick borne infections triggers the deficiencies, which gives Lyme the foothold...
One of my biggest beefs with the IDSA guidelines is that they do not consult the immunology community. I wish the clinical immunologists would pair up with the infectious disease docs and put their heads together.