Serum carnitine concentration is decreased in patients with Lyme borreliosis

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RitaA
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Serum carnitine concentration is decreased in patients with Lyme borreliosis

Post by RitaA » Tue 8 Mar 2016 23:44

http://www.ncbi.nlm.nih.gov/pubmed/26943315
Postepy Hig Med Dosw (Online). 2016 Mar 4;70(0):180-5. doi: 10.5604/17322693.1196388.

Serum carnitine concentration is decreased in patients with Lyme borreliosis.

Kępka A1, Pancewicz SA2, Janas RM1, Świerzbińska R2.

Author information

1 Department of Biochemistry, Radioimmunology and Experimental Medicine, The Children's Memorial Health Institute, Warsaw, Poland.
2 Department of Infectious Diseases and Neuroinfections, Medical University of Białystok, Białystok, Poland.

Abstract

BACKGROUND:

Lyme borreliosis (LB) is a serious infectious disease. Carnitine plays a crucial role in metabolism and inflammatory responses. Carnitine may be important in improving neuronal dysfunction and loss of neurons.

AIM:

To evaluate serum carnitine concentration in adult patients with various clinical types of LB.

MATERIAL/METHODS:

Groups: 1) patients with erythema migrans (EM, n=16), 2) neuroborreliosis (NB, n=10), 3) post-Lyme disease (PLD, n=22) and healthy controls (HC, n=32). Total (TC) and free (FC) carnitine were determined with the spectrophotometric method.

RESULTS:

TC levels (44.9±10.4, 28.0±8.4, 35.9±15.6 μmol/L) in the EM, NB and PLD patients were lower than in HC (54.0±11.4 μmol/L), p < 0.001. FC levels (32.7±7.7, 23.6±6.8, 26.3±11.2 μmol/L) in the EM, NB and PLD patients were lower than in HC (40.5±7.6 μmol/L), p < 0.001. AC levels (12.2±5.2, 4.4±2.6, 9.6±7.4 μmol/L) in the EM, NB and PLD patients were lower in the NB and PLD patients than in HC (13.5±8.40 μmol/L), p <0.001. AC/FC ratio was 0.31±0.14, 0.18±0.09, 0.39±0.33 in the EM, NB and PLD patients.

CONCLUSIONS:

LB patients exhibit a significant decrease of their serum carnitine concentrations. The largest changes were in the NB and PLD patients. To prevent late complications of the disease a possibility of early supplementation with carnitine should be considered. Further studies are required to explain the pathophysiological significance of our findings.

PMID: 26943315 [PubMed - in process]

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LHCTom
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Re: Serum carnitine concentration is decreased in patients with Lyme borreliosis

Post by LHCTom » Sun 13 Mar 2016 3:30

FYI: Metabolomics CFS/ME study also showed 90%+ had L-Carnitine @ 3 sigma below normal controls.
The greater the ignorance, the greater the dogmatism.

Attributed to William Osler, 1902

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