Rhodaba Ebady, Alexandra F. Niddam, Anna E. Boczula, Yae Ram Kim, Nupur Gupta, Tian Tian Tang, Tanya Odisho, Hui Zhi, Craig A. Simmons, Jon T. Skare, Tara J. Moriarty5,
Full text available from:
http://www.cell.com/cell-reports/fullte ... 16)31059-2
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A less scientific but more easily understood article about this study can be found in Scientific American:Highlights
•Biomechanical characterization of bacterial-vascular interactions
•Identified catch bond-mediated bacterial vascular adhesion mechanism
•Conserved vascular interaction strategies in bacteria and host cells
Systemic dissemination of microbes is critical for progression of many infectious diseases and is associated with most mortality due to bacterial infection. The physical mechanisms mediating a key dissemination step, bacterial association with vascular endothelia in blood vessels, remain unknown. Here, we show that endothelial interactions of the Lyme disease spirochete Borrelia burgdorferi under physiological shear stress mechanistically resemble selectin-dependent leukocyte rolling. Specifically, these interactions are mediated by transfer of mechanical load along a series of adhesion complexes and are stabilized by tethers and catch bond properties of the bacterial adhesin BBK32. Furthermore, we found that the forces imposed on adhesive bonds under flow may be small enough to permit active migration driven by bacterial flagellar motors. These findings provide insight into the biomechanics of bacterial-vascular interactions and demonstrate that disseminating bacteria and circulating host immune cells share widely conserved mechanisms for interacting with endothelia under physiological shear stress.
Something to Grapple with: How Wily Lyme Disease Prowls the Body
The sneaky germ uses a mechanism like that of white blood cells to reach vulnerable tissues and hide from antibiotics
http://www.scientificamerican.com/artic ... tter-Share