Eur J Paediatr Neurol. 2017 Nov 24. pii: S1090-3798(17)30179-4. doi: 10.1016/j.ejpn.2017.10.010. [Epub ahead of print]
Pediatric stroke related to Lyme neuroborreliosis: Data from the Swiss NeuroPaediatric Stroke Registry and literature review.
Monteventi O1, Steinlin M2, Regényi M2, Roulet-Perez E3, Weber P4, Fluss J5.
1 Pediatric Neurology Unit, Pediatrics Subspecialities Service, Geneva Children's Hospital, Switzerland.
2 Department of Neuropediatrics, Development and Rehabilitation, University Children's Hospital, Inselspital Bern, Switzerland.
3 Pediatric Neurology and Neurorehabilitation Unit, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
4 University Children's Hospital Basel, Division of Neuropediatrics and Developmental Medicine, Basel, Switzerland.
5 Pediatric Neurology Unit, Pediatrics Subspecialities Service, Geneva Children's Hospital, Switzerland.
BACKGROUND: Cerebrovascular complications of Lyme neuroborreliosis (LNB) are poorly documented in the paediatric population.
METHODS: We performed a retrospective analysis from prospectively registered cases of acute ischemic stroke (AIS) from the Swiss NeuroPaediatric Stroke Registry (SNPSR) from 2000 to 2015. Only cases with serologically confirmed LNB were included. In addition, a literature review on paediatric stroke cases secondary to Lyme neuroborreliosis in the same time frame was performed.
RESULTS: 4 children out of 229 children with arterial ischemic childhood stroke and serologically confirmed LNB were identified in the SNPSR giving a global incidence of 1.7%. Median age was 9.9 years. A prior history of tick bites or erythema migrans (EM) was reported in two cases. Clinical presenting signs were suggestive of acute cerebellar/brainstem dysfunction. On imaging, three children demonstrated a stroke in the distribution of the posterior inferior cerebellar artery. The remaining fourth child had a "stroke-like" picture with scattered white matter lesions and a multifocal vasculitis with prominent basilar artery involvement. Lymphocytic pleocytosis as well as intrathecal synthesis of Borrelia burgdorferi antibodies were typical biological features. Acute intravenous third generation cephalosporins proved to be effective with rapid improvement in all patients. No child had recurrent stroke. Data from the literature concerning eight patients gave similar results, with prominent posterior circulation stroke, multifocal vasculitis and abnormal CSF as distinctive features.
CONCLUSIONS: Lyme Neuroborreliosis accounts for a small proportion of paediatric stroke even in an endemic country. The strong predilection towards posterior cerebral circulation with clinical occurrence of brainstem signs associated with meningeal symptoms and CSF lymphocytosis are suggestive features that should rapidly point to the diagnosis. This can confirmed by appropriate serological testing in the serum and CSF. Clinicians must be aware of this rare neurological complication of Lyme disease that demands specific antibiotic treatment.
Copyright © 2017 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.
KEYWORDS: Cerebrovascular; Child; Lyme; Neuroborreliosis; Pediatric stroke; Vasculitis
PMID: 29208342 DOI: 10.1016/j.ejpn.2017.10.010
Topics with information and discussion about published studies related to Lyme disease and other tick-borne diseases.
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