Clocking the lyme spirochete.

Topics with information and discussion about published studies related to Lyme disease and other tick-borne diseases.
Post Reply
User avatar
Yvonne
Posts: 2421
Joined: Fri 27 Jul 2007 16:02

Clocking the lyme spirochete.

Post by Yvonne » Sun 24 Feb 2008 11:14

PLoS ONE. 2008 Feb 20;3(2):e1633.Links

Clocking the lyme spirochete.Malawista SE, de Boisfleury Chevance A.

Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America.

In order to clear the body of infecting spirochetes, phagocytic cells must be able to get hold of them. In real-time phase-contrast videomicroscopy we were able to measure the speed of Borrelia burgdorferi (Bb), the Lyme spirochete, moving back and forth across a platelet to which it was tethered. Its mean crossing speed was 1,636 microm/min (N = 28), maximum, 2800 microm/min (N = 3). This is the fastest speed recorded for a spirochete, and upward of two orders of magnitude above the speed of a human neutrophil, the fastest cell in the body. This alacrity and its interpretation, in an organism with bidirectional motor capacity, may well contribute to difficulties in spirochete clearance by the host.

PMID: 18286190 [PubMed - in process]
Listen to all,
plucking a feather from every passing goose,
but follow no one absolutely

Nick
Posts: 299
Joined: Wed 19 Sep 2007 19:10
Location: Zeeland, Netherlands

Re: Clocking the lyme spirochete.

Post by Nick » Sun 24 Feb 2008 22:01

now we want to see actual videos from this research, with human immune cells chasing Borrelia :mrgreen:

minitails2
Posts: 1001
Joined: Sat 3 Nov 2007 10:27

Re: Clocking the lyme spirochete.

Post by minitails2 » Mon 25 Feb 2008 12:44

I love this reseach. Very visual. I guess if you can't catch the bad guys, you can't stop 'em. :woohoo:

Just like the woowoo guy. :woohoo:

I would love to see that chase, too. :mrgreen:

User avatar
Yvonne
Posts: 2421
Joined: Fri 27 Jul 2007 16:02

Re: Clocking the lyme spirochete.

Post by Yvonne » Wed 5 Mar 2008 9:53

Bb moving back and forth along a platelet. Time-lapse (16x normal) phase-contrast videomicrocopy :

http://www.pubmedcentral.nih.gov/articl ... d=18286190
Listen to all,
plucking a feather from every passing goose,
but follow no one absolutely

Joe Ham
Posts: 489
Joined: Fri 27 Jul 2007 6:15
Location: New Mexico, USA

Re: Clocking the lyme spirochete.

Post by Joe Ham » Fri 7 Mar 2008 4:47

It looks like Malawista, one of Steere's buddies, thinks he has discovered something important about the fact of spirochete motility; that Bb can evade phagocytes by outrunning them.

However, Gasser made that point about 13 years ago.
Gasser talking about the combination of roxithromycin and co-trimoxazole (Bactrim):

"Most interestingly, however, the motility of B. burgdorferi was markedly reduced even when the two drugs were combined at very low concentrations. ... It appears that the reduced motility of B. burgdorferi makes the pathogen more accessible to the immune system."

http://www.ncbi.nlm.nih.gov/pubmed/7782 ... d_RVDocSum

Who knows, maybe in another 13 years Malawista will discover that Bb can also evade immune system by morphing to the L-forms.

User avatar
LymeEnigma
Posts: 1512
Joined: Sun 28 Oct 2007 18:26
Location: The Nevada Desert, USA
Contact:

Re: Clocking the lyme spirochete.

Post by LymeEnigma » Fri 7 Mar 2008 17:44

Isn't it funny how there exists so much forgotten knowledge among the IDSA camp? It must be a short-term memory problem....

Post Reply