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Re: The Neuropsychiatric Assessment of Lyme Disease

Posted: Thu 8 Apr 2010 19:03
by Yvonne
Pol Merkur Lekarski. 2010 Jan;28(163):53-5.

Coexisting of borreliosis, depression and psoriasis--case report

[Article in Polish]

Ogłodek E, Moś D, Araszkiewicz A.

Katedra Psychiatrii Collegium Medicum w Bydgoszczy. maxeve@interia.pl

Abstract

Lyme disease is a multisystem infectious disease with a wide variety of symptoms involving the skin as well as the nervous system. Lyme disease is caused by spirochaete Borrelia burgdorferi transmitted by Ixodes ticks in endemic regions. A case of 45 year old woman suffering from borreliosis, psoriasis and depression is presented in the paper. In the study a standardized screening list was applied to evaluate the psychiatric health state--Classification of Psychic Disorders (DSM-IV) and Hamilton Scale. Patient was diagnosed with a major depressive episode (MDE) according to DSM-IV Diagnosis Criteria. Patient obtained a score 21 on the 24-item in Hamilton Rating Scale of Depression. Primary manifestation of boreliosis in patient with psoriasis increase a risk of depression.

PMID: 20369726

Re: The Neuropsychiatric Assessment of Lyme Disease

Posted: Wed 11 Aug 2010 19:37
by Yvonne
Psychiatr Pol. 1999 Mar-Apr;33(2):241-50.

Neuroborreliosis: a psychiatric problem?

[Article in Polish]

Popławska R, Szulc A, Zajkowska J, Pancewicz S.

Kliniki Chorób Psychicznych AM w Białymstoku.

Abstract
The authors review the literature concerning clinical characteristics of neuroborreliosis with special focus on mental disorders. The patients develop mental disorders during the acute phase of the disease and even after several years. These disorders are often accompanied with various neurological syndromes. The authors discuss the most common mental disorders connected with neuroborreliosis: encephalopathy, cognitive disorders, dementia, depression, anxiety disorders. The paper describes the problem of neuroborreliosis in psychiatry, especially in the endemic regions.

PMID: 10786229

Re: The Neuropsychiatric Assessment of Lyme Disease

Posted: Fri 13 Aug 2010 10:15
by Yvonne
Psychiatr Pol. 2009 May-Jun;43(3):353-61.

Polymorphic mental disorders in the course of Lyme borreliosis--case study

[Article in Polish]

Helon B, Tłuczek TW, Buczyjan A, Adamczyk-Helon A, Wojnarowicz M, Mikuła R, Ciciński P, Bojarska J.

Wojewódzki Podkarpacki Szpital Psychiatryczny w Zurawicy, Rózana.

Abstract
In this article an inpatient case of The Mental Hospital in Zurawica was described, in which first qualitative disorders of consciousness, later a paranoid syndrome and a depressive syndrome preceded diagnosis of Lyme Borreliosis. After the therapy that was applied we observed residual organic mood disorders in the patient. Below, authors demonstrate one of the many clinical situations, where the appearance of polymorphic mental disorders preceded the appearance of a somatic disease.

PMID: 19725428

Re: The Neuropsychiatric Assessment of Lyme Disease

Posted: Sun 27 May 2012 3:46
by RitaA
A 2011 case report from Norway:

http://tidsskriftet.no/article/2228114/en_GB/
Case report

A woman in her 50s with manic psychosis

A R Pasareanu Å Mygland Ø Kristensen

A woman who was compulsorily hospitalised for manic psychosis proved to need quite different treatment from what was first assumed necessary.

A woman in her late 50s with no prior history of mental disorder was compulsorily hospitalised under the Mental Health Act to an acute psychiatric ward for psychiatric assessment because she was perceived as psychotic by the A&E doctor. She had been at the family cabin with her husband for a few weeks, and in the last two days had become increasingly agitated and restless, talking loudly and disjointedly and sleeping little.

On admission to the psychiatric ward she was oriented with respect to time, place and situation. She had pressured speech, a euphoric mood and motoric acceleration. There were no signs of hallucinosis or evident flawed logic in her thinking. The patient was previously healthy, apart from known, correctly treated hypertension. On admission she complained of vague pains in the shoulder and neck that were difficult to describe precisely. Her temperature and blood tests were normal. Since it was a case of a first-episode psychosis, CT of the brain was ordered, and this was negative.

Given her physical restlessness, reduced need for sleep, pressured speech and elated mood calling for hospitalisation, the patient fulfilled the diagnostic criteria for acute mania (Table 1) (1). Because of the acute onset, delirium (acute confusion) was a possible differential diagnosis, but it was regarded as improbable because she was oriented with respect to time, place and situation, and neither the content nor the level of her consciousness was altered. Nor were there any factors that might cause a disposition to delirium, such as fever, metabolic disorder, abuse of drugs/alcohol or dementia. No significance was attached to the pain in her neck and shoulder at this point.

[Table 1 Diagnostic criteria for mania (ICD-10). For a diagnosis to be made, A plus at least 3 B symptoms must be present.]

The patient was treated for two days with oxazepam25 mg × 3 and quetiapine 50 mg + 150 mg per day for mania, but this had only a moderate effect. She began to complain of severe pain in the neck and shoulder musculature, and her gait became more unsteady and staggering.

The moderate effect of medication, the patient’s age, pain and neurological symptoms in the form of unsteadiness and impaired walking function led to the suspicion that the patient’s mania was secondary to a neurological disease. Following neurological examination, she was therefore moved to the Neurology Department for further assessment, two days after her arrival.

The patient complained of neck pain on admission to the Neurology Department. A clinical examination revealed reduced strength in the right hand and tense neck musculature. There was no stiffness of the neck or fever. Blood tests, CT of the brain and X-rays of the shoulder and neck were normal. A spinal puncture was performed, and the cerebrospinal fluid was pathological with an elevated cell count of 351 leukocytes per mm (reference range ≤ 4), and protein 1.60 g/l (reference range 0.10 - 0.40 g/l). She could not recall having had either a tick bite or an erythema migrans-like rash.

Neck pain, reduced strength in the right hand and cerebral symptoms in the form of mania accompanied by an elevated cell count in the spinal fluid gave rise to suspicion of a combination of meningoradiculitis and encephalitis, probably caused by a virus or a borrelia infection (neuroborreliosis). Other possible causes, such as purulent bacteria infection or an autoimmune disease/vasculitis were regarded as less probable because of the lack of systemic signs of infection, the mononuclear appearance of the leukocytes and normal blood tests.

Treatment for meningoencephalitis was started, with intravenous aciclovir (750 mg × 3) and ceftriaxone (2 g × 1) because of suspicion of a virus or borrelia infection. The symptoms declined substantially in the course of a couple of days. After three days the polymerase chain reaction test (PCR) for herpes simplex in the spinal fluid was negative, and acyclovir was terminated. Borrelia antibody analysis revealed an elevated serum level (IgM was found, but not quantified, and IgG was 144 mg/l), but there was a normal ratio between the serum level and the cerebrospinal fluid (negative borrelia antibody index). Treatment with ceftriaxone continued. After six days, a cerebrospinal fluid test showed a decline in the number of leukocytes to 185 per mm3, but the borrelia antibody index was still negative. She was discharged in a satisfactory condition after 14 days of ceftriaxone treatment with the diagnosis probable neuroborreliosis. No appointment was made for follow-up.

After two months she was hospitalised again because of tiredness and suspected recurrence. Her neurological and psychiatric status was then normal. The cell count in her cerebrospinal fluid was normal, but the borrelia antibody index was now positive. These findings dismissed the suspicion of recurrence of encephalitis, but confirmed that she had suffered neuroborreliosis. Her tiredness was regarded as a natural consequence of suffering encephalitis in combination with a heavy work load. She was discharged without specific treatment and was told she could expect a gradual improvement of the tiredness. After her discharge she was followed up by the mental health service and has been hospitalised once in a regional psychiatric centre. The reason for her admission was suspected depression, which could not be confirmed. But the patient was tired because of a heavy work load, and she was given a short respite stay.

At her last check-up, just over four months after her first hospitalisation, the patient appeared to be mastering her life situation. She was still struggling with the after-effects of the borreliosis in the form of headache and fatigue, but was improving.

The diagnosis of definite neuroborreliosis is based on clinical neurological symptoms accompanied by the findings of an elevated number of leukocytes in the cerebrospinal fluid and a positive borrelia antibody index. The suspicion of neuroborreliosis in our patient was maintained in an early phase and treatment was completed even though the antibody index was negative in the first two cerebrospinal fluid tests. The diagnosis was confirmed after two months, when the antibody index was positive. The antibody response is often delayed in borrelia infections (2). In an early phase of neuroborreliosis (symptom duration less than six weeks) the antibody index is negative in about 26 %, and serum may also be antibody negative. Our patient was almost symptom-free after the antibiotics treatment, but after a while noticed reduced working capacity and tiredness. Recurrence of the infection was suspected, but a normal cell count in the cerebrospinal fluid disproved this. The presence of antibodies alone did not indicate an active infection. It has recently been shown that about 50 % of patients suffer from tiredness 30 months after being treated for neuroborreliosis.

Discussion

Mania is a pathological condition characterised by an elated mood and heightened physical and mental activity. The mood is not in keeping with the patient’s situation, and may vary from carefree joviality to uncontrollable exhilaration. The exhilaration is accompanied by increased energy which leads to overactivity, incessant talking and a reduced need for sleep. Attention cannot be retained, and the person is easily distracted. Self-esteem is often inflated, with grandiosity and excessive self-confidence. Loss of normal social inhibitions may lead to behaviour that is frivolous, reckless or inappropriate and atypical of the person. Mania can be confused with delirium - a state of confusion that is characterised by acute onset, disorientation, visual hallucinations and a fluctuating level of consciousness (4).

Mania is often part of bipolar disorder (primary mania), but there may also be many other causes (secondary mania). The lifetime prevalence of primary mania is 1 % (5). The prevalence of secondary mania is far more difficult to quantify because of great variation in the different sub-groups. Secondary mania may be due to medication, intoxicants, metabolic disturbances or neurological disease (Table 2) (6). It may be difficult to identify secondary mania. Advanced age and somatic symptoms point to increased suspicion. Elderly adults are in the danger zone because of a higher prevalence of medical and neurological diseases. Mania in the elderly is often incorrectly diagnosed as dementia with agitation (7).

[Table 2 Somatic causes of secondary mania (modified from (6))]

It is worth noting that mania and other psychiatric symptoms may be due to neurological disease even if the image representations of the brain (CT, SPECT and MRI), electroencephalography (EEG) and blood tests are normal. This increases the need for a thorough neurological examination, including spinal fluid analysis, in an early phase. Spinal fluid tests may be useful for identifying infection (neuroborreliosis, neurosyphilis, viruses and other infectious agents that may cause encephalitis), carcinomatosis, autoimmune diseases and some neurodegenerative diseases (dementia, Creutzfeldt-Jakob’s Disease) (8).

Lyme borreliosis is a tick-borne infection caused by the spiral bacterium Borrelia burgdoferi. The disease may be localised to the skin (erythema migrans) or disseminated to other organ systems, most commonly the nervous system. Most cases of disseminated disease that are reported to the Norwegian Surveillance System for Communicable Diseases (MSIS) come from the counties of Aust-Agder, Vest-Agder, Vestfold, Telemark, Sogn og Fjordane and Møre og Romsdal, but cases have also been reported further north in Norway (8).

Borrelia infection in the nervous system (neuroborreliosis) may give rise to a number of different symptoms that are all accompanied by an elevated number of mononuclear leukocytes in the cerebrospinal fluid (7). The most common symptoms are pain (located in the neck, back, chest, abdomen or limbs) due to meningoradiculitis, and facial paresis. In rare cases, the infection may attack the central nervous system and cause confusion, tremor and other involuntary movements, unsteadiness, single-side paralysis, aphasia and psychosis. The diagnosis neuroborreliosis is based on the presence of neurological symptoms combined with a concurrent elevated number of lymphocytes in the cerebrospinal fluid and borrelia antibody production revealed by a high ratio between the levels in spinal fluid and serum (also called positive antibody index). However, the antibody index in cerebrospinal fluid is negative in about 26 % of patients in the early phase (symptom duration less than six weeks), and serum may also be antibody negative (9). Fewer than half have a definite elicited history with a tick bite or erythema migrans. Antibiotic treatment results in rapid relief of symptoms and should be started as soon as there is clinical suspicion of neuroborreliosis and a high number of lymphocytes are found in the spinal fluid. The elapse of a long period from the onset of symptoms to treatment is associated with a higher frequency of long-term problems (3, 10). Doxycycline tablets 200 mg daily for 14 days is just as effective as intravenous ceftriaxone in cases of affection of the peripheral nervous system (facial paresis and meningoencephalitis), but for encephalitis many would recommend intravenous ceftriaxone twice daily for 14 days (11).

Our patient suffered from mania caused by borrelia encephalitis. Various psychiatric symptoms of neuroborreliosis have been described (12, 13), but the onset of a manic pathological picture has not previously been described in Europe. A case history from North America describes a patient who developed a bipolar-like syndrome with both depression and mania as the first symptoms of borrelia infection (14). The many manifestations of neuroborreliosis indicate that it should be regarded as a possible differential diagnosis and cerebrospinal fluid should be tested on the first manifestation of psychotic illness, particularly when it is accompanied by pain.

Conclusion

In the case of first-episode psychosis, including mania, a neurological cause should be considered even if the image representation of the brain and the blood tests are normal. Neuroborreliosis and other encephalitic diseases are diagnosed by means of spinal fluid tests, and rapidly applied treatment improves the prognosis.

The patient has consented to the publication of the article.

Litteratur

1. World Health Organization. The ICD-10 Classification of mental and behavioural disorders. Clinical descriptions and diagnostic guidelines. Genève: World Health Organization, 1992.

2. Ljøstad U, Skarpaas T, Mygland A. Clinical usefulness of intrathecal antibody testing in acute Lyme neuroborreliosis. Eur J Neurol 2007; 14: 873 - 6. [PubMed] [CrossRef]

3. Eikeland R, Mygland A, Herlofson K et al. European neuroborreliosis: quality of life 30 months after treatment. Acta Neurol Scand 2011; 124: 349 - 54. [PubMed] [CrossRef]

4. Malt UF, Retterstøl N, Dahl AA. Lærebok i psykiatri. Oslo: Gyldendal Akademisk, 2005.

5. Merikangas KR, Akiskal HS, Angst J et al. Lifetime and 12-month prevalence of bipolar spectrum disorder in the National Comorbidity Survey replication. Arch Gen Psychiatry 2007; 64: 543 - 52. [PubMed] [CrossRef]

6. McDonald WM. Epidemiology, etiology, and treatment of geriatric mania. J Clin Psychiatry 2000; 61 (Suppl 13): 3 - 11. [PubMed]

7. Brooks JO 3rd, Hoblyn JC. Secondary mania in older adults. Am J Psychiatry 2005; 162: 2033 - 8. [PubMed] [CrossRef]

8. Deisenhammer F, Egg R, Giovannoni G et al. EFNS guidelines on disease-specific CSF investigations. Eur J Neurol 2009; 16: 760 - 70. [PubMed] [CrossRef]

9. Folkehelseinstituttet. MSIS-statistikk. http://www.msis.no (1.6.2011).

10. Ljøstad U, Mygland A. Remaining complaints 1 year after treatment for acute Lyme neuroborreliosis; frequency, pattern and risk factors. Eur J Neurol 2010; 17: 118 - 23. [PubMed] [CrossRef]

11. Mygland Å, Ljøstad U, Fingerle V et al. EFNS guidelines on the diagnosis and management of European Lyme neuroborreliosis. Eur J Neurol 2010; 17: 8 - 16, e1 - 4. [PubMed] [CrossRef]

12. Fallon BA, Kochevar JM, Gaito A et al. The underdiagnosis of neuropsychiatric Lyme disease in children and adults. Psychiatr Clin North Am 1998; 21: 693 - 703, viii. [PubMed] [CrossRef]

13. Markeljevic J, Sarac H, Rados M. Tremor, seizures and psychosis as presenting symptoms in a patient with chronic lyme neuroborreliosis (LNB). Coll Antropol 2011; 35 (suppl 1): 313 - 8. [PubMed]

14. Fallon BA, Nields JA, Parsons B et al. Psychiatric manifestations of Lyme boreliosis. J Clin Psychiatry 1993; 54: 263 - 8.

Received 10 June 2011, first revision submitted 16 September 2011, approved 29 September 2011. Medical editor: Erlend Aasheim.

DOI
10.4045/tidsskr.11.0683
Available via dx.doi.org

DOI (Digital Object Identifier) is a unique ID that guarantees permanent links to electronic documents.

Authors
Adrian Razvan Pasareanu

Solvang Regional Psychiatric Centre

Sørlandet Hospital

Adrian Razvan Pasareanu (born 1974) Registrar Specialist at Solvang Regional Psychiatric Centre, Sørlandet Hospital

The author has completed the ICMJE form and declares no conflicts of interest.

Åse Mygland

Neurology Department

and

Department for Adult Habilitation

Sørlandet Hospital Kristiansand

and

Institute of Clinical Medicine

University of Bergen

Åse Mygland (born 1958) Specialist in neurology and Senior Consultant at the Neurology Department and Department for Adult Habilitation, Sørlandet Hospital Kristiansand. Adjunct Professor at the Institute of Clinical Medicine, University of Bergen.

The author has completed the ICMJE form and declares no conflicts of interest.

Øistein Kristensen
Addiction Unit

Sørlandet Hospital Kristiansand

Øistein Kristensen (born 1945) Specialist in psychiatry and Senior Consultant at the Addiction Unit, Sørlandet Hospital, Kristiansand.

The author has completed the ICMJE form and declares no conflicts of interest.

Re: The Neuropsychiatric Assessment of Lyme Disease

Posted: Sun 27 May 2012 21:58
by RitaA
http://www.ncbi.nlm.nih.gov/pubmed/22422416
Tijdschr Psychiatr. 2012;54(3):235-43.

[Signs and significance of a tick-bite: psychiatric disorders associated with Lyme disease].

[Article in Dutch]
Sno HN.
Source
Zaans Medisch Centrum, Postbus 210, 1500 EE Zaandam. Sno.h@zaansmc.nl

Abstract

BACKGROUND:

In view of the increased prevalence of Lyme disease and the increased attention given to the disease in the media, psychiatrists are more likely to be confronted with patients with psychiatric disorders that may be linked to Lyme disease.

AIM:

To present an overview of some diagnostic problems and psychiatric disorders that can occur in the context of Lyme disease.

METHOD:

The literature was reviewed systematically with the help of Medline and Embase for the period 1990-October 2010 and relevant articles were studied that were mentioned in the reference lists of the articles selected.

RESULTS:

The most frequently discussed psychiatric disorders associated with Lyme disease are depressive and psychotic disorders and cognitive impairment with memory and concentration disorders. Medically unexplained symptoms can be attributed to hitherto unrecognised Lyme disease. The fear of contracting Lyme disease can in itself lead to psychiatric decompensation.

CONCLUSION:

Further investigations into borrelia-infection are indicated in case of atypical psychiatric disorders and/or an atypical response to treatment and when the anamnesis and/or physical examination are suggestive of Lyme disease.

PMID: 22422416
[PubMed - indexed for MEDLINE]

Free full text
http://www.ncbi.nlm.nih.gov/pubmed/15951656
Clin J Pain. 2005 Jul-Aug;21(4):362-3.

Painful hallucinations and somatic delusions in a patient with the possible diagnosis of neuroborreliosis.

Bär KJ, Jochum T, Häger F, Meissner W, Sauer H.

Source

Department of Psychiatry, Friedrich-Schiller-University of Jena, Jena, Germany

Abstract

Neuroborreliosis has become the most frequently recognized tick-borne infection of the nervous system in Europe and the United States. In addition to dermatological, cardiac, articular, and neurologic manifestations, psychiatric disorders such as depression, panic attacks, and schizophrenia-like psychosis can also arise. We report on a 61-year-old woman who developed a severe pain syndrome following several tick bites. She was diagnosed with neuroborreliosis; she received various courses of antibiotics over several years, but without any clinical improvement in her condition. Her eventual admission to a psychiatric ward due to mental symptoms and neuroleptic treatment led to a dramatic improvement of her pain symptoms. However, increasing delusions disclosed a psychotic episode, which ceased over time. We discuss therapeutic difficulties and psychiatric complications in the absence of a clear-cut diagnosis of neuroborreliosis. Although this patient might have suffered from late-onset schizophrenia with painful hallucinations right from the start of her disease, the case highlights psychiatric complications that might be associated with neuroborreliosis.

PMID: 15951656 [PubMed - indexed for MEDLINE]