http://www.lymeneteurope.org/forum/view ... f=5&t=5660
These are the items in which I am wondering what the relation is:X-member wrote:I also (together with late Lyme borreliosis) have immunodeficiency (CVID).hv808ctr wrote: hv808ct wrote:
That’s why we have an immune system. Absent a functioning one, all the antibiotics in the world aren’t going to save you from a cut finger.
Do you think that our immune system always can "take care of" bacteria that are not killed by a short course of Doxycycline?
1) Out of 9 people with persistent borreliosis that I have asked so far, 7 of them have some major form of IgG, IgA, and IgM deficiency and most have been formally diagnosed with CVID. (One person hasn't been tested and one did not want to comment on their medical history). Ok, big assumption here as the sample size is tiny, but let's hypothesize that this could hold true for a decent subset of the people with persistent borreliosis.
2) The follow up comments from this study here, talking about how adding a TNF inhibitor to a previously unculturable sample post antibiotic treatment, caused the sample to become culturable.
Thread: http://www.lymeneteurope.org/forum/view ... f=5&t=5476
Anti–Tumor Necrosis Factor–a Treatment Activates Borrelia burgdorferi Spirochetes 4 Weeks after Ceftriaxone Treatment in C3H/He Mice
Heta Yrja¨ na¨ inen,1 Jukka Hyto¨ nen,1 Xiao-yu R. Song,3 Jarmo Oksi,2 Kaija Hartiala,1 and Matti K. Viljanen1
Departments of 1 Medical Microbiology and 2 Medicine, University of Turku, Turku, Finland; 3 Centocor, Inc., Malvern, Pennsylvania
http://jid.oxfordjournals.org/content/1 ... 9.full.pdf
3) When looking up info on CVID, I stumbled upon this statement:
http://ghr.nlm.nih.gov/condition/common ... deficiency
http://ghr.nlm.nih.gov/gene/TNFRSF13BMutations in at least 10 genes have been associated with CVID. Approximately 10 percent of affected individuals have mutations in the TNFRSF13B gene. The protein produced from this gene plays a role in the survival and maturation of B cells and in the production of antibodies. TNFRSF13B gene mutations disrupt B cell function and antibody production, leading to immune dysfunction. Other genes associated with CVID are also involved in the function and maturation of immune system cells, particularly of B cells; mutations in these genes account for only a small percentage of cases.
What is the official name of the TNFRSF13B gene?
The official name of this gene is “tumor necrosis factor receptor superfamily, member 13B.
List of related gene changes that are associated with common variable immune deficiency:TNFRSF13B gene mutations cause CVID in some people but do not appear to cause immune problems in others.
http://ghr.nlm.nih.gov/condition/common ... ed+Gene(s)
Also included on that list is:
http://ghr.nlm.nih.gov/gene/TNFRSF13CWhat is the official name of the TNFRSF13C gene?
The official name of this gene is “tumor necrosis factor receptor superfamily, member 13C.
So I wonder, if those with CVID/immune deficiencies and persistent borreliosis, happen to have genetics that make them more susceptible to Lyme? It's already known that having CVID alone makes it harder to fight off infections in general, but I wonder if there is some added role of TNF/TNF genetics that makes it even worse?