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Simultaneous Borrelia Miyamotoi and burgdorferi in Leukemic

Posted: Mon 16 Feb 2015 19:23
by inmacdonald
Simultaneous infections of human patients with Borrelia Miyamotoi and Borrelia burgdorferi have been
rarely documented.
In the Russian outbreak of Borrelia Miyamotoi infections reported in Emerging Infectious Diseases,
not a single patient was found to simultaneously be infected with Borrelia Miyamotoi and Borrelia burgdorferi.

Herein we document with FISH method and Molecular Beacon DNA Probe pairs specific for
Borrelia burgdorferi [ Flab-burgdorferi -BBO 0147 and Inner cell membrane BBO 0740 : FITC labeled]
Borrelia Miyamotoi [FlaB-miyamotoi (red) and GlpQ-Miyamotoi : Cy5 and Cy3 labelled respectively]

There was a High Infectious Burden of borrelia from each species; approximately equal in spirochete density for each of the species of borrelia
per 1000x microscopic field of view using Epifluorescence microscopy ; in peripheral blood at the time of blood draw.

It is well known that Spirochetemic levels may vary considerably in the same patient over time, without
the effect of antibiotic or antispirochetal therapies

The patient is Leukemic [BCR/ABL positive}
It is interesting to recall that the first case of human Borrelia miyamotoi infection developed in a patient with
a hematologic malignancy. [ See Case Report in the New England Journal of Medicine]

Image Data; FISH method with Molecular Beacon DNA probes specific for B. Miyamotoi ( Red/yellow] and
B. burgdorferi ( FITC - Green)

Double infection Miyamotoi and burgdorferi.jpg
Miyamotoi and Burgdorferi borrelia Co-infections in Leukemic patient
Double infection Miyamotoi and burgdorferi.jpg (140.66 KiB) Viewed 1292 times


Respectfully submitted,

Alan B. MacDonald, MD, FCAP
February 16,2015

Re: Simultaneous Borrelia Miyamotoi and burgdorferi in Leuke

Posted: Mon 6 Apr 2015 14:38
by greyone
I saw a study once that i believe was done at harvard with mice who were given ALL leukemia and were given one of the tetracycline type of drugs and the researchers were able to turn the leukemia on and off by giving or withdrawing the antibiotic.
Raised many questions in my mind.