Meta-analysis of the diagnostic accuracy of serology tests for Lyme borreliosis
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Under laboratory circumstances, the serological tests for Lyme disease have a sensitivity of around 80% and a specificity of around 95%, or even up to 100%. For Lyme arthritis and acrodermatitis, the sensitivity was around 93%. However, in clinical studies in neuroborreliosis and unspecified Lyme borreliosis, the specificity of these tests decreased to 81% and 77% respectively. Overall, the results were very heterogeneous with sensitivity and specificity ranging from 0% to 100%. Ig-type was the most important source of heterogeneity, with tests using a combination of IgM and IgG being the most sensitive and least specific ones.