I have disabled the links to the publication as they are no longer valid.
Source: http://austinpublishinggroup.com/chronic-diseases/download.php?file=fulltext/chronicdiseases-v4-id1025.pdf [PDF-alert]
Appendix-A: Peer-Reviewed Evidence of Persistence of Lyme Disease Spirochete Borrelia Burgdorferi and Other Tickborne Diseases:Chronic Dis Int - Volume 4 Issue 1 - 2017
ISSN 2379-7983 | http://www.austinpublishinggroup.com
Chronic Lyme Disease: A Working Case Definition
Stricker RB* and Fesler MC
International Lyme & Associated Diseases Society, Bethesda, MD; Union Square Medical Associates, San Francisco, CA, USA
*Corresponding author: Raphael B. Stricker, Union Square Medical Associates, 450 Sutter Street, Suite 1504, San Francisco, CA 94108, USA
Received: April 07, 2017; Accepted: April 25, 2017; Published: May 03, 2017
Although Lyme disease is the most common tickborne illness in the USA and Eurasia, the pathophysiology and clinical course of chronic Lyme disease (CLD) have not been formally defined. The purpose of this paper is to present a working case definition of CLD based on analysis of more than 700 peerreviewed publications. According to this definition, CLD is a multisystem illness with diverse musculoskeletal, neuropsychiatric and/or cardiovascular manifestations that result from ongoing infection with pathogenic members of the Borrelia spirochete complex often associated with other tickborne disease (TBD) pathogens. To qualify for the diagnosis of CLD, patients must have Lymecompatible symptoms and signs that are either consistently or variably present for six or more months. Two subcategories of CLD include untreated chronic Lyme disease (CLD-U) and chronic Lyme disease following a limited course of antibiotic treatment (CLD-T). The symptom patterns and optimal therapy of CLD require further study.
Keywords: Lyme disease; Borrelia burgdorferi; Tickborne disease; Chronic infection
Appendix-B: Studies used for identification of symptoms and signs in CLD:
Also see LNE topic: Chronic Lyme Disease: a Case Definition at Last.
Edit 20170627-1433: added note at the top of this message.