On the Adversarials Against Chronicity in Lyme

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inmacdonald
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On the Adversarials Against Chronicity in Lyme

Post by inmacdonald » Thu 3 Sep 2015 17:59

" Sure, Swift, and WRONG" is a leitmotif to confront those who place Chronic Lyme Borreliosis patients
into the virtual Dustbin of Medical practice. Read on, gentle subscribers...

In Place of "Lyme" let us graduate to "Borrelia". Why? because Miyamotoi borrelia has emerged as a world wide public health problem. Miyamotoi borrelia illnesses are indistinguishable in their clinical presentations from burgdorferi borrelia infections.No current blood testing methods are available to confirm Miyamotoi borrelia infections. Nonetheless, Miyamotoi "Borreliosis" mimics all of the clinical illnesses of burgdorferi "Borreliosis". Additional confounding "inconvenient TRUTHS" are: multiple co-infections by infectomes other than spirochetal agents, co-exist in many chronically ill patients with tick borne illnesses. Multi-strain burgdorferi which simultaneously cause human infections, have been documented. In Vivo DNA fluxes of infecting spirochetes result in changes in structural proteins. These are "novel" proteins, and are not always represented on paper strips used in Lyme ELISA and LYME Western Blot laboratory testing. Failure to match the antibodies IN THE BODY and BLOODSTREAM with proteins from the B31 reference borrelia burgdorferi organism, sets the stage for FALSE NEGATIVE results in blood serology testing. Disbelief in the reality of Chronic forms of tick borne illnesses is promulgated by the members of the Infectious Disease Society of America [IDSA], and by the highest levels of the Centers for Disease Control and Prevention [CDC], has produced an attitude among some practicing physicians that Chronic is a "Crock". This is defacto ridicule, repudiation, and rejection of the legitimate medical needs of many persons in the now annually "minted" 300,000 per USA per annum new cases of Lyme Disease { Borreliosis}.
Disbelief in the mainstream medical community: decisions... -"sure", "Swift", and "WRONG" -ie.
the example which follows: -
For the 'Neurosis' (sic) which can cause suffocation deaths by uncontrolled swelling of the tongue and upper airway tissues.....]Medicine named a condition -"Hereditary Angioneurotic Edema"

{which is not a tick borne illness}.

After "AngioNEUROTIC" appeared in medical textbooks , it was discovered that patients with Angioedema actually ALL lacked the important regulatory protein, C1q esterase Inhibitor.


Modern textbooks now have been re-written.
The correct term for C1q esterase inhibitor deficiency patients is"Angioedema".
{ Expunged forever from medicine was the notion that "angioedema"patients had a Neurotic Illness.)


Let us chart a learning trajectory to comprehend chronic Borreliosis syndromes in humankind, as :
1. Real 2. Diagnosable with DNa Probe technologies, 3. Treatable with prolonged courses of appropriate Pulsed dose anti-infectomes [plural]therapies.

Respectfully,
Alan B. MacDonald, MD, Fellow, College of American Pathologists

hv808ct
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Re: On the Adversarials Against Chronicity in Lyme

Post by hv808ct » Fri 4 Sep 2015 2:06

Miyamotoi borrelia has emerged as a world wide public health problem.

Miyamotoi borrelia illnesses are indistinguishable in their clinical presentations from burgdorferi borrelia infections.

No current blood testing methods are available to confirm Miyamotoi borrelia infections.
Then how do we know it’s a worldwide public health problem if it can’t be diagnosed or differentiated?

What is a Florida-wide public health problem is sun stroke and dehydration.

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inmacdonald
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Re: On the Adversarials Against Chronicity in Lyme

Post by inmacdonald » Sat 5 Sep 2015 15:20

Miyamotoi borrelia manuscripts can easily be found in the PubMed or in Scholar Google:

Miyamotoi borrelia-Recent Literature Citations:

Krause, Peter J., Sukanya Narasimhan, Gary P. Wormser, Lindsay Rollend, Erol Fikrig, Timothy Lepore, Alan Barbour, and Durland Fish. "Human Borrelia miyamotoi infection in the United States." New England Journal of Medicine 368, no. 3 (2013): 291-293.

Gugliotta, Joseph L., Heidi K. Goethert, Victor P. Berardi, and Sam R. Telford III. "Meningoencephalitis from Borrelia miyamotoi in an immunocompromised patient." New England Journal of Medicine 368, no. 3 (2013): 240-245.

Platonov, Alexander E., Ludmila S. Karan, Nadezhda M. Kolyasnikova, Natalya A. Makhneva, Marina G. Toporkova, Victor V. Maleev, Durland Fish, and Peter J. Krause. "Humans infected with relapsing fever spirochete Borrelia miyamotoi, Russia." Emerging infectious diseases 17, no. 10 (2011): 1816.
Chowdri, Hanumara Ram, Joseph L. Gugliotta, Victor P. Berardi, Heidi K. Goethert, Philip J. Molloy, Sherri L. Sterling, and Sam R. Telford. "Borrelia miyamotoi infection presenting as human granulocytic anaplasmosis: a case report." Annals of internal medicine 159, no. 1 (2013): 21-27.

Sarksyan, D. S., A. E. Platonov, L. S. Karan, I. E. Malinin, L. I. Khalitova, V. I. Shakhov, M. V. Dudarev, O. V. Malinin, and V. V. Maleev. "[Clinical presentation of" new" tick-borne borreliosis caused by Borrelia miyamotoi]." Terapevticheskii arkhiv 84, no. 11 (2011): 34-41.

Fonville, Manoj, Ingrid HM Friesema, Paul D. Hengeveld, Arieke Docters van Leeuwen, Seta Jahfari, Margriet G. Harms, Arnold JH van Vliet et al. "Human exposure to tickborne relapsing fever spirochete Borrelia miyamotoi, the Netherlands." Emerging infectious diseases 20, no. 7 (2014): 1244.

Geller, Julia, Lidia Nazarova, Olga Katargina, Lilian Järvekülg, Natalya Fomenko, and Irina Golovljova. "Detection and genetic characterization of relapsing fever spirochete Borrelia miyamotoi in Estonian ticks." PLoS One 7, no. 12 (2012): e51914.

Richter, Dania, Daniela B. Schlee, and Franz-Rainer Matuschka. "Relapsing fever–like spirochetes infecting European vector tick of Lyme disease agent." Emerging infectious diseases 9, no. 6 (2003): 697.

Hovius, Joppe WR, Bob de Wever, Maaike Sohne, Matthijs C. Brouwer, Jeroen Coumou, Alex Wagemakers, Anneke Oei et al. "A case of meningoencephalitis by the relapsing fever spirochaete Borrelia miyamotoi in Europe." Lancet 382, no. 9892 (2013): 658.

Tokarz, Rafal, Komal Jain, Ashlee Bennett, Thomas Briese, and W. Ian Lipkin. "Assessment of polymicrobial infections in ticks in New York State." Vector-borne and zoonotic diseases 10, no. 3 (2010): 217-221.

Dibernardo, Antonia, Tyler Cote, Nicholas H. Ogden, and L. Robbin Lindsay. "The prevalence of Borrelia miyamotoi infection, and co-infections with other Borrelia spp. in Ixodes scapularis ticks collected in Canada." Parasites & vectors 7, no. 1 (2014): 1-8.

Hv808ct is either ....Reading impaired, OR,
Not up to date with English language peer reviewed literature, OR,
Hw is mean spirited with malice of forethought/ AND feigned ignorance of what has been a very timely topic in borrelia diseases in humankind.

Eddie, please assist hv808ct to live in the 21st Century


Respectfully,
Alan b. MacDonald ,MD , Fellow, College of American Pathologists
Sept5, 2015

hv808ct
Posts: 256
Joined: Wed 30 Jul 2008 4:11

Re: On the Adversarials Against Chronicity in Lyme

Post by hv808ct » Sat 5 Sep 2015 16:14

Thanks but I'm familiar with the literature. What bothers me is the hyperbole, the bad typing, and the overuse of capitalization.

amr
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Re: On the Adversarials Against Chronicity in Lyme

Post by amr » Sat 5 Sep 2015 18:32

Dear Dr. MacDonald, I've watched several of your presentations on Youtube and I have to say Thank you for dedicating your life to such a controversial disease. It takes an awful lot of sacrifice to go up against the main-stream in medicine and to devote one's whole education and experience to a disease that will cause one to be seen as an out-cast in many Medical 'professionals' view.
I admire your choice to become a Pathologist as well. That's truly the dirty work that takes someone that can see into every part of the biological make-up of a once living creature. Most just specialize in one branch of medicine and will send you to differing Specialists for common or even minor ailments. That becomes costly for most patients. But the cost that you're paying by choosing to focus on Borellia - I can only slightly imagine. I for one would be only too glad to donate my remains if I should pass-on while you are still practicing --- something that I had never thought of doing because I've lost an awful lot of trust in the over-all Medical community over the last 10 yrs.

I hesitate to ask any questions of you Sir, because I'm not sure if it would be appropriate to do so - so please feel free to not give an answer but I'll put this one question out there for whomever may be familiar with the research on this topic and the answer to it.

I've wondered in your work or the research of yourself or others, what has been found in the bones of persistent Bb infected creatures - animal or human and if found in bones - what was the effect?

Thank you again for your work!
Respectfully, amr

amr
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Joined: Mon 17 Aug 2015 5:41

Re: On the Adversarials Against Chronicity in Lyme

Post by amr » Sun 6 Sep 2015 5:36

I meant to add in my question -- effects on bones, other than Lyme arthritis -- though I've wondered if Lyme arthritis is more like osteo or rheumatoid?

Thanks to all again!

fastuno
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Joined: Tue 4 Nov 2014 18:01

Re: On the Adversarials Against Chronicity in Lyme

Post by fastuno » Sun 6 Sep 2015 14:58

hv808ct...
"Then how do we know it’s a worldwide public health problem if it can’t be diagnosed or differentiated?"
By the same way we know that two-tier testing for Borrelia b. B31 is grossly unreliable & from the concurrent admittance of the CDC of the growing number of LD cases (300,000+/yr) you OBTUSE MORON (since the overuse of capital letters distresses you as it does)!

What type of blundering idiot does not see the discovery of B. miyamotoi (or re-discovery) as a potential global concern, especially if it closely follows the footprints of B. burgdorferi & Syphilis & is not being tested for? At MINIMUM you should be more considerate & respectful of such studies and not blurt out such nonsensical requests from such a small & elegant study, which obviously serves as a prologue to bigger questions (including the question of spread). Your undermining tendencies strikes me as the kind of persona that would have gone against Christopher Colombus or Charles Darwin, because the outcome may not conform to your parti pris dockets.

What is the issue that you have? Do you not believe in DNA Probes/Hybridization? Do you not believe that there may be pathogens for some of the various labeled diseases? Or are you worried that truths will hurt your job security? Is that it, you only follow & promote science that will perpetuate further science and not meet any dead ends?

We can extrapolate your turbid mentality and ask then how do we know that science & medicine are really beneficial to humanity? For every one person we try and help, a dozen more issues arise. Science & medicine then become a pointless venture that only drains society and once again you become jobless.


"What is a Florida-wide public health problem is sun stroke and dehydration."

What is more of a Florida-wide & GLOBAL-WIDE problem are your pejorative conclusions & ill-will toward a healthy view on science and what has now become a significant public health hazard. You are the least bit considerate & your attempt to obfuscate only unveils you for what you truly are.

It is ironic how these simple single celled organisms work together harmoniously to cause infection, yet imbeciles like hv808ct have gone against their own race!!!

paulieinct
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Re: On the Adversarials Against Chronicity in Lyme

Post by paulieinct » Tue 22 Sep 2015 21:16

I just read yesterday that the ILADS guidelines for diagnosis and treatment have been accepted and posted by the National Guidelines Clearing House.

This is HUGE. ILADS guidelines are now the ONLY guidelines for Lyme diagnosis and treatment that are validated in accordance with IOM criteria.

This follows on the heels of Alan MacDonald's ground-breaking research showing Bb and Bm persistence in the brain as the cause of Alzheimers.

AND........British billionaire's announcement that his entire family has Lyme after years of misdiagnosis :

http://www.telegraph.co.uk/news/celebri ... sease.html


IDSA/CDC/ALDF cabal is folding like a house of cards. Wormser, Steere, Auerwater, et al have been seen retreating to their bunkers as the angry mobs descend.

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