Maintaining IgM Antibodies for Years, Poor Prognosis in LD

Medical topics with questions, information and discussion related to Lyme disease and other tick-borne diseases.
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Re: Maintaining IgM Antibodies for Years, Poor Prognosis in

Post by ChronicLyme19 » Mon 2 Feb 2015 17:46

Thanks for bumping this up, Spanky's diversions aside, this was a good thread. It seems that IgM and IgG interpretation is a huge mess.

I would say if you have IgM or IgG antibodies you can at least conclude you were exposed to Lyme, but whether or not they are indicative of an active infection, how long each last after symptom cession, and what patterns may be seen in acute or chronic borreliosis seems to be yet to be well understood. It would make sense like many have suggested that changes in IgM bands or amounts would be significant evidence towards an active infection.

I'm not quite sure a good enough study has been done on this yet. I'd like to see a long term 10-20 year study of everyone who has suspected or confirmed Lyme, not just those with strong EMs, testing at regular intervals for all IgM and IgG bands, documenting all symptoms changes and severity (not just arthritis type), and response or lack thereof to abx and any effects of co-infection or other underlying diseases. I'll also like to add in, something that doesn't seem to have been studied in any of these, is overall immune function. If you have patients with IgM or IgG bands fluctuating, what were their overall IgM, IgG, or globulin levels doing throughout this period? If new IgM bands are popping up, is that happening with an overall increase of total IgM. Or how about examining other immune system changes that may be happening with the Lyme band changes.

I'll add my own case history here as an anecdote.

June 2011 bitten by tick, 3-4 weeks later severe flu-like symptoms. (Also had tick bites as a child but no symptoms from those).

June 2011 (~1 month) - Quest
IgG 41 pos
IgG 58 pos
Total globulin level normal

November 2011 (~5 months) - Quest
IgG 41 pos
IgG 45 pos
Total globulin level normal

Sometime in the first 9 months of 2012 developed severe hypogammaglobulinemia (total IgG in 200s, IgM and IgA also well below normal)

Started abx treatment October 2012

November 2012 (~1 year 5 months) - Quest
IgG 41
Immunodeficient IgM, IgG, IgA

April 2013 (1 year 10 months) - IGeneX
IgG 41 - IND
IgM 23-25 positive
IgM 31 positive
Immunodeficient IgM, IgG, IgA

November 2014
No longer immunodeficient IgM, IgA
Still suspected immunodeficient IgG, but able to reduce sub-Q IgG therapy

I'm going to be asked to be retested this month since my IgA and IgM levels are back to normal and symptoms under control if on abx. I'm curious to see what bands, if any will show up.
Half of what you are taught is incorrect, but which half? What if there's another half missing?

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Re: Maintaining IgM Antibodies for Years, Poor Prognosis in

Post by Martian » Fri 8 May 2015 14:35

Claudia wrote:Bumping old topic, looking for new information.
Hi Claudia,

Your son's western blot test results are striking, with several IgM bands maintaining for years, while only band 41 kDa or nothing showing at the IgG. But with even Igenex stating that "It is known that Western blots, especially IgM, can give false positive results with some viral and bacterial infections.", I would also consider cross-reactions.

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