Surprising mechanism of acid reflux damage identified by researchers

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RitaA
Posts: 2768
Joined: Thu 1 Jul 2010 8:33

Surprising mechanism of acid reflux damage identified by researchers

Post by RitaA » Wed 18 May 2016 17:16

https://www.sciencedaily.com/releases/2 ... 191818.htm
Surprising mechanism of acid reflux damage identified by researchers

Date: May 17, 2016
Source: UT Southwestern Medical Center
Summary: The 'acid' in 'acid reflux' may not be the direct cause of damage to the esophagus as previously suspected, according to researchers following conclusion of their study.

The "acid" in "acid reflux" may not be the direct cause of damage to the esophagus as previously suspected, according to researchers at UT Southwestern Medical Center and Dallas VA Medical Center.

For more than 80 years, it has been assumed that stomach acid backing up through the esophagus damaged the lining of the esophagus by causing chemical burns, but their research suggests that the damage in patients with gastroesophageal reflux disease (GERD) actually occurs through an inflammatory response prompted by the secretion of proteins called cytokines.

"Although this radical change in the concept of how acid reflux damages the esophagus of GERD patients will not change our approach to its treatment with acid-suppressing medications in the near future, it could have substantial long-term implications," said senior author Dr. Stuart Spechler, Professor of Internal Medicine at UT Southwestern and Chief of the Department of Gastroenterology at the Dallas VA Medical Center.

"Someday we might treat GERD with medications that target the cytokines or inflammatory cells that really cause the damage to the esophagus," said co-senior author Dr. Rhonda Souza, Professor of Internal Medicine at UT Southwestern and staff physician with the Department of Gastroenterology at the Dallas VA Medical Center.

[snip]
Medications that target cytokines or inflammatory cells could potentially be very useful in a variety of disorders since chronic inflammation (that is no longer beneficial) seems to be one common denominator of many modern day medical conditions.

lou
Posts: 215
Joined: Fri 2 Nov 2007 0:41

Re: Surprising mechanism of acid reflux damage identified by researchers

Post by lou » Tue 24 Jan 2017 4:08

But of course we would not want to bother finding out what is causing the inflammation, and that will definitely have long term implications.

Guess they have not been told that it is lack of stomach acid that may produce GERD, and the fix is adding it. Or at least that is what some people think.

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