Infectious Agents and Neurodegenerative Diseases: Exploring the links

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RitaA
Posts: 2768
Joined: Thu 1 Jul 2010 8:33

Infectious Agents and Neurodegenerative Diseases: Exploring the links

Post by RitaA » Sun 8 Jan 2017 7:59

https://www.ncbi.nlm.nih.gov/m/pubmed/28049398/
Infectious Agents and Neurodegenerative Diseases: Exploring the links.

Alam MZ, et al. Curr Top Med Chem. 2017.

Authors
Alam MZ, Alam Q, Kamal MA, Jiman-Fatani AA, Azhar EI, Khan MA, Haque A1.

Author information
1King Fahd Medical Research Center, King Abdulaziz University, P. O. Box 80216, Jeddah 21589, Saudi Arabia. Saudi Arabia.

Citation
Curr Top Med Chem. 2017 Jan 3. [Epub ahead of print]

Abstract

Recent studies have shown that bacterial and viral infections are risk factors for various neurodegenerative diseases such as Amyotrophic lateral sclerosis (ALS), Multiple Sclerosis (MS), Alzheimer's disease (AD), and Lyme disease (LD). However, it is still controversial how the infections play a role in neurological diseases progression. Infections in central nervous system may lead multiple damages in infected and neighboring cells. The infection leads to the activation of inflammatory processes and host immune responses, which acts as defense mechanism and also causes damage to the host neuronal functions and viability. Several bacterial and viral pathogens have been reported for neurodegeneration, such as the production and deposit of misfolded protein aggregates, oxidative stress, deficient autophagic processes, synaptopathies and neuronal death. These effects may act in combination with other factors, like aging, metabolic diseases and the genetic makeup of the host. We will focus in this review on the possible link between neurodegeneration and infections particularly Chlamydophila pneumoniae, Borrelia burgdorferi, Mycoplasma etc.

lou
Posts: 215
Joined: Fri 2 Nov 2007 0:41

Re: Infectious Agents and Neurodegenerative Diseases: Exploring the links

Post by lou » Tue 24 Jan 2017 3:51

This looks very good. But I can't find it in any of the journal's table of contents for this year's issues so far.

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