The latest publications of scientific medical research, articles and news on Lyme disease from many resources are automatically displayed here.
Tuesday 4 October 2022
Leptospirosis is an emerging zoonosis caused by pathogenic Leptospira spp. Because rodents are natural hosts of Leptospira, rodent models of pathogenesis have been limited, but are valuable to understand infection in reservoir animals even in the absence of disease. Mouse models of infection provide advantages due to genetic tractability, so developing murine models of Leptospira infection is crucial for further understanding the biology of this organism. Previously our laboratory developed a short-term murine model of Borrelia burgdorferi hematogenous dissemination to investigate the role of adhesion proteins on bacterial survival and dissemination within a host. Here we adapt this model to Leptospira. C3H/HeJ mice are anesthetized, inoculated intravenously, and then bacteria are allowed ...
Tuesday 4 October 2022
PHM Session: Dermatologic Disease Presentations, Skin Color, and Disparities in Medical Care Presenters: Deawodi Ladzekpo, MD, and Sonya Tang Girdwood, MD, PhD, Cincinnati Children’s Hospital, Ohio Drs. Ladzekpo and Tang Girdwood brought to light disparities in medical care that result from the underrepresentation of dermatologic conditions in patients of color (POC). The topic was introduced with a reference to Lyme disease, in particular the fact that many POC aren’t diagnosed until they have advanced disease compared to white patients. The question was then put forth: Do POC not have symptoms until they are in the later stages? Or rather, does the lack of awareness of the appearance of erythema migrans on the skin of color delay their diagnosis and treatment? The first half of the s...
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Tuesday 4 October 2022
J Integr Neurosci. 2022 Mar 28;21(2):73. doi: 10.31083/j.jin2102073.ABSTRACTAlzheimer's disease (AD) is the leading cause of dementia worldwide. Individuals affected by the disease gradually lose their capacity for abstract thinking, understanding, communication and memory. As populations age, declining cognitive abilities will represent an increasing global health concern. While AD was first described over a century ago, its pathogenesis remains to be fully elucidated. It is believed that cognitive decline in AD is caused by a progressive loss of neurons and synapses that lead to reduced neural plasticity. AD is a multifactorial disease affected by genetic and environmental factors. The molecular hallmarks of AD include formation of extracellular β amyloid (Aβ) aggregates, neurofibrilla...
Tuesday 4 October 2022
Australas J Dermatol. 2022 Jul 18. doi: 10.1111/ajd.13894. Online ahead of print.NO ABSTRACTPMID:35849704 | DOI:10.1111/ajd.13894 (Source: The Australasian Journal of Dermatology)
Tuesday 4 October 2022
CONCLUSIONS: There are many possible explanations for increased hsTnT values in different types of patients in the absence of acute cardiac damage. Nonetheless our results raise the possibility that subclinical cardiac involvement may be more common in ELD than previously recognized. Further studies will be necessary to elucidate the significance of this finding.PMID:35414496 (Source: Annals of Clinical and Laboratory Science)
Tuesday 4 October 2022
CMAJ. 2022 Jul 18;194(27):E939-E941. doi: 10.1503/cmaj.220112.NO ABSTRACTPMID:35851530 | PMC:PMC9299745 | DOI:10.1503/cmaj.220112 (Source: cmaj)
Tuesday 4 October 2022
CONCLUSIONS: There are many possible explanations for increased hsTnT values in different types of patients in the absence of acute cardiac damage. Nonetheless our results raise the possibility that subclinical cardiac involvement may be more common in ELD than previously recognized. Further studies will be necessary to elucidate the significance of this finding.PMID:35414496 (Source: Annals of Clinical and Laboratory Science)
Tuesday 4 October 2022
CMAJ. 2022 Jul 18;194(27):E950. doi: 10.1503/cmaj.220945.NO ABSTRACTPMID:35851535 | PMC:PMC9299737 | DOI:10.1503/cmaj.220945 (Source: Canadian Medical Association Journal)
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Tuesday 4 October 2022
Two girls from central Switzerland presented in spring with a history of localised skin colour change and swelling of their ears. The 4-year-old girl complained of painless erythematous swelling in the earlobe (figure 1A) for 4 weeks. The 6-year-old girl also complained of painless erythematous swelling with a similar appearance at the helix (figure 1B), but for 5 months. Initially the parents noticed swelling and mild redness which then changed to a red-violaceous appearance. Both children had been participating in outdoor activities the previous late summer and autumn with exposure to ticks. Borrelia burgdorferi serology (immunoblot with multiple positive IgG surface antigen responses) was positive in both girls. Lyme-associated lymphocytoma (lymphadenosis benigna cutis) was diagnosed. B...
Tuesday 4 October 2022
CMAJ. 2022 Jul 18;194(27):E939-E941. doi: 10.1503/cmaj.220112.NO ABSTRACTPMID:35851530 | PMC:PMC9299745 | DOI:10.1503/cmaj.220112 (Source: Canadian Medical Association Journal)
Tuesday 4 October 2022
In conclusion, although PTLDS may be exacerbated by past trauma, trauma plays a role in only a subgroup of PTLDS. Whether addressing prior trauma can improve outcomes in this subgroup requires study. (Source: The Journal of Nervous and Mental Disease)
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Tuesday 4 October 2022
CMAJ. 2022 Jul 18;194(27):E950. doi: 10.1503/cmaj.220945.NO ABSTRACTPMID:35851535 | PMC:PMC9299737 | DOI:10.1503/cmaj.220945 (Source: cmaj)
Tuesday 4 October 2022
Study of Lyme Immunology and Clinical Events (SLICE) (study page |release notes) (Source: dbGaP, the database of Genotypes and Phenotypes)
Tuesday 4 October 2022
CMAJ. 2022 Jul 18;194(27):E939-E941. doi: 10.1503/cmaj.220112.NO ABSTRACTPMID:35851530 | PMC:PMC9299745 | DOI:10.1503/cmaj.220112 (Source: cmaj)
Tuesday 4 October 2022
Contributors : Charles Chiu ; Venice Servellita ; Jerome Bouquet ; Alison Rebman ; Ting Yang ; Mark Soloski ; John AucottSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensLyme disease is a tickborne illness that causes an estimated 476,000 infections annually in the United States. New diagnostic tests are urgently needed, as existing antibody-based assays lack sufficient sensitivity and specificity. Using transcriptome profiling by RNA-Seq, targeted RNA sequencing, and machine learning (ML)-based classification of 218 subjects, we identified a 31-gene Lyme disease classifier (LDC) to discriminate early Lyme patients from “non-Lyme” controls infected with influenza, bacteremia, or tuberculosis or uninfected asymptomatic controls. Among the 31 classif...
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Tuesday 4 October 2022
CMAJ. 2022 Jul 18;194(27):E950. doi: 10.1503/cmaj.220945.NO ABSTRACTPMID:35851535 | PMC:PMC9299737 | DOI:10.1503/cmaj.220945 (Source: Canadian Medical Association Journal)
Tuesday 4 October 2022
In this study, a more detailed characterization of the putative regulatory factor encoded by the intergenic region was pursued. In cis complemented strains featuring mutations aimed at eliminating potential protein translation were capable of full tissue colonization, suggesting that the functional product encoded by the intergenic region is not a protein as previously predicted. In trans complementation of the intergenic region resulted in elevated transcription of the sequence compared to wild type and was found to completely abolish infectivity in both immunocompetent "and immunodeficient mice. Quantitative analysis of transcription of the intergenic region by wild-type B. burgdorferi showed it to be highly induced during murine infection relative to in vitro culture. Lastly, targeted d...
Tuesday 4 October 2022
CMAJ. 2022 Jul 18;194(27):E939-E941. doi: 10.1503/cmaj.220112.NO ABSTRACTPMID:35851530 | PMC:PMC9299745 | DOI:10.1503/cmaj.220112 (Source: Canadian Medical Association Journal)
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Tuesday 4 October 2022
This study suggests opportunities for improved LD prevention, including advising cat owners of their increased risk. Although patterns in adoption of LD prevention methods remain poorly understood, concern about LD risk does motivate their use. (Source: International Journal of Environmental Research and Public Health)
Tuesday 4 October 2022
CMAJ. 2022 Jul 18;194(27):E950. doi: 10.1503/cmaj.220945.NO ABSTRACTPMID:35851535 | PMC:PMC9299737 | DOI:10.1503/cmaj.220945 (Source: cmaj)
Tuesday 4 October 2022
International Journal of Environmental Research and Public Health doi: 10.3390/ijerph19105833 Authors: Nicholas Johnson Lawrence Paul Phipps Kayleigh M. Hansford Arran J. Folly Anthony R. Fooks Jolyon M. Medlock Karen L. Mansfield Where ticks are found, tick-borne diseases can present a threat to human and animal health. The aetiology of many of these important diseases, including Lyme disease, bovine babesiosis, tick-borne fever and louping ill, have been known for decades whilst others have only recently been documented in the United Kingdom (UK). Further threats such as the importation of exotic ticks through human activity or bird migration, combined with changes to either the habitat or climate could increase the risk of tick-borne disease persistence and transmis...
Tuesday 4 October 2022
CMAJ. 2022 Jul 18;194(27):E939-E941. doi: 10.1503/cmaj.220112.NO ABSTRACTPMID:35851530 | PMC:PMC9299745 | DOI:10.1503/cmaj.220112 (Source: Canadian Medical Association Journal)
Tuesday 4 October 2022
Z. O. Allehebi et al. (Source: Emerging Infectious Diseases Journal)
Tuesday 4 October 2022
CMAJ. 2022 Jul 18;194(27):E950. doi: 10.1503/cmaj.220945.NO ABSTRACTPMID:35851535 | PMC:PMC9299737 | DOI:10.1503/cmaj.220945 (Source: Canadian Medical Association Journal)
Tuesday 4 October 2022
In conclusion, CD56+ (NK + NK-T) cells produced IFN-γ shortly after exposure to B. burgdorferi and released soluble mediators that were able to activate keratinocytes. These observations underscore the important role of CD56+ (NK + NK-T) cells during early host defence when Borrelia burgdorferi enters the human skin during a tick bite.PMID:35569383 | DOI:10.1016/j.cyto.2022.155895 (Source: Cytokine)
Tuesday 4 October 2022
CMAJ. 2022 Jul 18;194(27):E939-E941. doi: 10.1503/cmaj.220112.NO ABSTRACTPMID:35851530 | DOI:10.1503/cmaj.220112 (Source: cmaj)
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Tuesday 4 October 2022
The Lyme disease spirochete Borrelia burgdorferi, encodes an elaborate antigenic variation system that promotes the ongoing variation of a major surface lipoprotein, VlsE. Changes in VlsE are continual and always one step ahead of the host acquired immune system, which requires 1–2 weeks to generate specific antibodies. By the time this happens, new VlsE variants have arisen that escape immunosurveillance, providing an avenue for persistent infection. This antigenic variation system is driven by segmental gene conversion events that transfer information from a series of silent cassettes (vls2-16) to the expression locus, vlsE. The molecular details of this process remain elusive. Recombinational switching at vlsE is RecA-independent and the only required factor identified to date is the ...
Tuesday 4 October 2022
CMAJ. 2022 Jul 18;194(27):E950. doi: 10.1503/cmaj.220945.NO ABSTRACTPMID:35851535 | DOI:10.1503/cmaj.220945 (Source: cmaj)
Tuesday 4 October 2022
CONCLUSION: Lyme's disease, a common disease of the west does exist in the Indian subcontinent as well. Because of increasing global travel and migration and change in vector habitat the disease seems to have percolated in the non endemic areas too. Proper history of travel or exposure to tick bite is important. We want to emphasize, Neuroborreliosis, a great mimicker may have diverse and varied neurological presentations and has a potential for reversibility with appropriate treatment even after a significant delay in diagnosis.PMID:35598127 (Source: Journal of the Association of Physicians of India)
Tuesday 4 October 2022
CMAJ. 2022 Jul 18;194(27):E939-E941. doi: 10.1503/cmaj.220112.NO ABSTRACTPMID:35851530 | DOI:10.1503/cmaj.220112 (Source: Canadian Medical Association Journal)
Tuesday 4 October 2022
Emerg Infect Dis. 2022 Jun;28(6):1170-1179. doi: 10.3201/eid2806.211335.ABSTRACTApproximately 476,000 cases of Lyme disease are diagnosed in the United States annually, yet comprehensive economic evaluations are lacking. In a prospective study among reported cases in Lyme disease-endemic states, we estimated the total patient cost and total societal cost of the disease. In addition, we evaluated disease and demographic factors associated with total societal cost. Participants had a mean patient cost of ≈$1,200 (median $240) and a mean societal cost of ≈$2,000 (median $700). Patients with confirmed disseminated disease or probable disease had approximately double the societal cost of those with confirmed localized disease. The annual, aggregate cost of diagnosed Lyme disease could be $3...
Tuesday 4 October 2022
CMAJ. 2022 Jul 18;194(27):E950. doi: 10.1503/cmaj.220945.NO ABSTRACTPMID:35851535 | DOI:10.1503/cmaj.220945 (Source: cmaj)
Tuesday 4 October 2022
Emerg Infect Dis. 2022 Jun;28(6):1170-1179. doi: 10.3201/eid2806.211335.ABSTRACTApproximately 476,000 cases of Lyme disease are diagnosed in the United States annually, yet comprehensive economic evaluations are lacking. In a prospective study among reported cases in Lyme disease-endemic states, we estimated the total patient cost and total societal cost of the disease. In addition, we evaluated disease and demographic factors associated with total societal cost. Participants had a mean patient cost of ≈$1,200 (median $240) and a mean societal cost of ≈$2,000 (median $700). Patients with confirmed disseminated disease or probable disease had approximately double the societal cost of those with confirmed localized disease. The annual, aggregate cost of diagnosed Lyme disease could be $3...
Tuesday 4 October 2022
CMAJ. 2022 Jul 18;194(27):E939-E941. doi: 10.1503/cmaj.220112.NO ABSTRACTPMID:35851530 | DOI:10.1503/cmaj.220112 (Source: Canadian Medical Association Journal)
Tuesday 4 October 2022
Emerg Infect Dis. 2022 Jun;28(6):1170-1179. doi: 10.3201/eid2806.211335.ABSTRACTApproximately 476,000 cases of Lyme disease are diagnosed in the United States annually, yet comprehensive economic evaluations are lacking. In a prospective study among reported cases in Lyme disease-endemic states, we estimated the total patient cost and total societal cost of the disease. In addition, we evaluated disease and demographic factors associated with total societal cost. Participants had a mean patient cost of ≈$1,200 (median $240) and a mean societal cost of ≈$2,000 (median $700). Patients with confirmed disseminated disease or probable disease had approximately double the societal cost of those with confirmed localized disease. The annual, aggregate cost of diagnosed Lyme disease could be $3...
Tuesday 4 October 2022
CMAJ. 2022 Jul 18;194(27):E950. doi: 10.1503/cmaj.220945.NO ABSTRACTPMID:35851535 | DOI:10.1503/cmaj.220945 (Source: Canadian Medical Association Journal)
Tuesday 4 October 2022
Emerg Infect Dis. 2022 Jun;28(6):1170-1179. doi: 10.3201/eid2806.211335.ABSTRACTApproximately 476,000 cases of Lyme disease are diagnosed in the United States annually, yet comprehensive economic evaluations are lacking. In a prospective study among reported cases in Lyme disease-endemic states, we estimated the total patient cost and total societal cost of the disease. In addition, we evaluated disease and demographic factors associated with total societal cost. Participants had a mean patient cost of ≈$1,200 (median $240) and a mean societal cost of ≈$2,000 (median $700). Patients with confirmed disseminated disease or probable disease had approximately double the societal cost of those with confirmed localized disease. The annual, aggregate cost of diagnosed Lyme disease could be $3...
Tuesday 4 October 2022
CMAJ. 2022 Jul 18;194(27):E939-E941. doi: 10.1503/cmaj.220112.NO ABSTRACTPMID:35851530 | DOI:10.1503/cmaj.220112 (Source: cmaj)
Tuesday 4 October 2022
Emerg Infect Dis. 2022 Jun;28(6):1170-1179. doi: 10.3201/eid2806.211335.ABSTRACTApproximately 476,000 cases of Lyme disease are diagnosed in the United States annually, yet comprehensive economic evaluations are lacking. In a prospective study among reported cases in Lyme disease-endemic states, we estimated the total patient cost and total societal cost of the disease. In addition, we evaluated disease and demographic factors associated with total societal cost. Participants had a mean patient cost of ≈$1,200 (median $240) and a mean societal cost of ≈$2,000 (median $700). Patients with confirmed disseminated disease or probable disease had approximately double the societal cost of those with confirmed localized disease. The annual, aggregate cost of diagnosed Lyme disease could be $3...
Tuesday 4 October 2022
CMAJ. 2022 Jul 18;194(27):E950. doi: 10.1503/cmaj.220945.NO ABSTRACTPMID:35851535 | DOI:10.1503/cmaj.220945 (Source: cmaj)
Tuesday 4 October 2022
Conclusions This is the largest UK review of neuroborreliosis. The presentation is usually typical, but atypical presentations vary and can be challenging. The majority of patients recover fully. amyrossrussell@gmail.com (Source: Journal of Neurology, Neurosurgery and Psychiatry)
Tuesday 4 October 2022
Viruses doi: 10.3390/v14071584 Authors: Charles E. Hart Frank A. Middleton Saravanan Thangamani Powassan virus (POWV) is a tick-borne neuroinvasive flavivirus endemic to North America. It is generally transmitted by the tick, Ixodes scapularis. This species also transmits Borrelia burgdorferi, the causative agent of Lyme disease. Infection with B. burgdorferi can result in arthritis, carditis, and neuroborreliosis. These pathogens experience sylvatic overlap. To determine the risk of human exposure to coinfected ticks, the interactions between POWV and B. burgdorferi are assessed in laboratory-infected I. scapularis. Adult male and female I. scapularis ticks are orally inoculated with either both pathogens, POWV only, B. burgdorferi only, or uninfected media. After twenty-one ...
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Tuesday 4 October 2022
A 44-year-old-female presented with 3 weeks history of sacral anaesthesia, painful left leg paraesthesia and urinary retention requiring intermittent self-catheterisation. A week prior, she had headache, flu-like symptoms and dysuria and received oral antibiotics for E-Coli urinary infection with a negative vaginal swab. She was systemically well. On examination, there was mild left ankle dorsiflexion and plantar flexion weakness, brisk lower limb reflexes and altered sensation in left L5 and bilateral S1 dermatomes. MRI of her whole spine showed subtle signal change in the conus medullaris. CSF revealed 113 white blood cells (80% lymphocytes) with normal protein and glucose and negative oligoclonal bands. Her CT chest,abdomen and pelvis was unremarkable as were: autoimmune and vasculitis ...
Tuesday 4 October 2022
ConclusionsTaken together, the studies examined in the present review emphasize that numerous acute and chronic infectious diseases share mechanisms that, when added to specific risk factors frequently found in older persons, contribute to considerably increase the risk of cognitive outcomes such as cognitive decline and dementia. This review may help to appreciate the role that infectious diseases play in cognitive trajectories and thus promote further investigation on the topic. (Source: Neurological Sciences)
Tuesday 4 October 2022
An 83-year-old woman was incidentally found to have hyponatremia (125 mmol/L) when undergoing inpatient colonoscopy because of unspecific gastrointestinal symptoms and weight loss; no pathology was found on endoscopy. Further biochemistry was in keeping with the syndrome of inappropriate antidiuretic hormone (SIADH) secretion (urinary sodium 66 mmol/L, urinary osmolality 321 mosmol/kg, low uric acid); adrenal and thyroid function as well as glucose were normal. The patient was remarkably fit for her age, she was a lifelong non-smoker and her only medication was candesartan for hypertension. (Source: The American Journal of Medicine)
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Tuesday 4 October 2022
One of the growing global health problems are vector-borne diseases, including tick-borne diseases. The most common tick-borne diseases include Lyme disease, tick-borne encephalitis, human granulocytic anaplasmosis, and babesiosis. Taking into account the metabolic effects in the patient’s body, tick-borne diseases are a significant problem from an epidemiological and clinical point of view. Inflammation and oxidative stress are key elements in the pathogenesis of infectious diseases, including tick-borne diseases. In consequence, this leads to oxidative modifications of the structure and function of phospholipids and proteins and results in qualitative and quantitative changes at the level of lipid mediators arising in both reactive oxygen species (ROS) and ROS enzyme–dependent reacti...
Tuesday 4 October 2022
Lyme Disease and the Expanded Spectrum of Blacklegged Tick-Borne Infections (Source: Infectious Diseases Clinics of North America)
Tuesday 4 October 2022
CONCLUSIONS: Taken together, the studies examined in the present review emphasize that numerous acute and chronic infectious diseases share mechanisms that, when added to specific risk factors frequently found in older persons, contribute to considerably increase the risk of cognitive outcomes such as cognitive decline and dementia. This review may help to appreciate the role that infectious diseases play in cognitive trajectories and thus promote further investigation on the topic.PMID:35867217 | DOI:10.1007/s10072-022-06280-9 (Source: Herpes)
Tuesday 4 October 2022
Healthcare providers frequently struggle to provide effective care to patients with chronic Lyme-associated symptoms (chronic Lyme disease, CLD), potentially causing these patients to feel misunderstood or neg... (Source: BMC Family Practice)
Tuesday 4 October 2022
Morgellons disease is a rare condition characterized by patient reporting multicolored fibers and other non-organic or organic particles embedded in and protruding from diffuse skin ulcerations. Although the scientific community is prone to believe that Morgellons disease is a psychiatric disorder, an infectious pathogenesis associated with Borrelia burgdorferi in the setting of Lyme disease has also been proposed. The histopathology is usually considered as non-specific. To illustrate this condition, we present the case of an adult woman with significant ulcerative skin lesions and cicatricial changes on the face, trunk, and arms. (Source: Clinics in Dermatology)
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Tuesday 4 October 2022
J Sch Nurs. 2022 Jun 1:10598405221099484. doi: 10.1177/10598405221099484. Online ahead of print.ABSTRACTHealthcare Professionals Working in Schools (HPWS) are responsible for providing health services to students and play a role in providing education to prevent illnesses, including tickborne diseases (TBD). Providing TBD education to children has been shown to increase prevention behaviors and knowledge of TBD symptoms, but little is known regarding the current state of TBD awareness among HPWS. In spring 2019 we conducted a cross-sectional knowledge, attitudes, and practices (KAP) survey of HPWS in two states with a high incidence of Lyme disease (LD) to inform design of TBD prevention programs. The survey queried general knowledge of TBDs, school practices regarding TBDs, and availabili...
Tuesday 4 October 2022
A new study has shown that taking a single dose of a widely used, cheap antibiotic within 3 days after condomless sex can help prevent chlamydia, syphilis, and gonorrhea, three sexually transmitted infections (STIs, also referred to as sexually transmitted diseases or STDs ) that have soared in the United States, Europe, and elsewhere over the past 2 decades. The study, mainly in men who have sex with men (MSM) in San Francisco and Seattle, was halted in May after an independent data monitoring board found that the strategy, known as doxycycline postexposure prophylaxis (doxyPEP), reduced the risk of chlamydia and gonorrhea by more than 60%—a result so convincing there was no need to continue the study. DoxyPEP also appeared to protect against syphilis, but too few cases occur...
Tuesday 4 October 2022
J Sch Nurs. 2022 Jun 1:10598405221099484. doi: 10.1177/10598405221099484. Online ahead of print.ABSTRACTHealthcare Professionals Working in Schools (HPWS) are responsible for providing health services to students and play a role in providing education to prevent illnesses, including tickborne diseases (TBD). Providing TBD education to children has been shown to increase prevention behaviors and knowledge of TBD symptoms, but little is known regarding the current state of TBD awareness among HPWS. In spring 2019 we conducted a cross-sectional knowledge, attitudes, and practices (KAP) survey of HPWS in two states with a high incidence of Lyme disease (LD) to inform design of TBD prevention programs. The survey queried general knowledge of TBDs, school practices regarding TBDs, and availabili...
Tuesday 4 October 2022
AbstractClimate change is adversely affecting the burden of infectious disease throughout the world, which is a health security threat. Climate-sensitive infectious disease includes vector-borne diseases such as malaria, whose transmission potential is expected to increase because of enhanced climatic suitability for the mosquito vector in Asia, sub-Saharan Africa, and South America. Climatic suitability for the mosquitoes that can carry dengue, Zika, and chikungunya is also likely to increase, facilitating further increases in the geographic range and longer transmission seasons, and raising concern for expansion of these diseases into temperate zones, particularly under higher greenhouse gas emission scenarios. Early spring temperatures in 2018 seem to have contributed to the early onset...
Tuesday 4 October 2022
J Sch Nurs. 2022 Jun 1:10598405221099484. doi: 10.1177/10598405221099484. Online ahead of print.ABSTRACTHealthcare Professionals Working in Schools (HPWS) are responsible for providing health services to students and play a role in providing education to prevent illnesses, including tickborne diseases (TBD). Providing TBD education to children has been shown to increase prevention behaviors and knowledge of TBD symptoms, but little is known regarding the current state of TBD awareness among HPWS. In spring 2019 we conducted a cross-sectional knowledge, attitudes, and practices (KAP) survey of HPWS in two states with a high incidence of Lyme disease (LD) to inform design of TBD prevention programs. The survey queried general knowledge of TBDs, school practices regarding TBDs, and availabili...
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Tuesday 4 October 2022
Acta Trop. 2022 Jul 29:106627. doi: 10.1016/j.actatropica.2022.106627. Online ahead of print.ABSTRACTInsects, ticks, and mites represent a threat to animal health globally, mainly due to their role as vectors of pathogens. Among the most important diseases, those transmitted by mosquitoes (e.g., malaria and arboviral infections) and ticks (e.g., Lyme borreliosis, babesiosis, and viral haemorrhagic fever) have a huge impact on human health. The principal methods available for reducing the public health burden of most vector-borne diseases are vector-based intervention relying to insecticides and acaricides. However, the use of these products is challenged by the introduction of invasive species, the quick development of physiological insecticide and acaricide resistance, and their non-targe...
Tuesday 4 October 2022
J Sch Nurs. 2022 Jun 1:10598405221099484. doi: 10.1177/10598405221099484. Online ahead of print.ABSTRACTHealthcare Professionals Working in Schools (HPWS) are responsible for providing health services to students and play a role in providing education to prevent illnesses, including tickborne diseases (TBD). Providing TBD education to children has been shown to increase prevention behaviors and knowledge of TBD symptoms, but little is known regarding the current state of TBD awareness among HPWS. In spring 2019 we conducted a cross-sectional knowledge, attitudes, and practices (KAP) survey of HPWS in two states with a high incidence of Lyme disease (LD) to inform design of TBD prevention programs. The survey queried general knowledge of TBDs, school practices regarding TBDs, and availabili...
Tuesday 4 October 2022
International Journal of Environmental Research and Public Health doi: 10.3390/ijerph19159449 Authors: Sarah P. Maxwell Connie L. McNeely Chris Brooks Kevin Thomas Determining interventions to combat disease often requires complex analyses of spatial-temporal data to improve health outcomes. For some vulnerable populations, obtaining sufficient data for related analyses is especially difficult, thus exacerbating related healthcare, research, and public health efforts. In the United States (U.S.), migrant and seasonal workers are especially affected in this regard, with data on health interventions and outcomes largely absent from official sources. In response, this study offers a multi-modal approach that involves triangulating geographically specified health data that incor...
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Tuesday 4 October 2022
ConclusionPADI2 expression was observed in diverse regions and cells of the CNS, and anti-PAD2 autoantibodies were associated with less severe symptoms in subsets of patients with MS and PTLD. These data suggest that anti-PAD2 antibodies may attenuate inflammation in diseases of different etiologies, which are united by high PADI2 expression in the target tissue. (Source: Frontiers in Neurology)
Tuesday 4 October 2022
Acute and chronic musculoskeletal pain is a common reason for referral to the pediatric rheumatologist. (1,2,3) The differential diagnosis is extensive; patients may be diagnosed with inflammatory joint pain, includingjuvenile idiopathic arthritis (JIA), arthritis related to infection (e.g.: reactive arthritis – including rheumatic fever and post-strep, viral arthritis, Lyme disease) and other autoimmune and inflammatory disorders such as systemic lupus erythematosus; painful non-inflammatory MSK disorders include overuse injuries (e.g.: patellofemoral pain syndrome (PFPS)), osteochondroses (i.e.: Osgoo d-Schlatter disease), benign joint hypermobility syndromes, benign limb pain of childhood; orthopedic disorders (e.g.: Legg-Calvé-Perthes and osteochondritis dissecans) and chronic MSK p...
Tuesday 4 October 2022
Lyme neuroborreliosis (LNB) is a tick-borne infection caused by the spirochete Borrelia burgdorferi sensu lato complex with various neurological manifestations. The recommended treatment for LNB in Swedish childr... (Source: BMC Pediatrics)
Tuesday 4 October 2022
Wien Klin Wochenschr. 2022 Aug 9. doi: 10.1007/s00508-022-02064-5. Online ahead of print.ABSTRACTBorrelial lymphocytoma is a rare cutaneous manifestation of early localized European Lyme borreliosis. It manifests as a nodule or plaque with a diameter of up to a few centimeters. The lesion is, as a rule, solitary. It is more common in children than in adults and, in contrast to erythema migrans and acrodermatitis chronica atrophicans, has male predominance. A tick bite has been reported in approximately one half of patients; the tick bite is usually at the site or in the vicinity of the later borrelial lymphocytoma. The predilection site for the development of lesions is the breast in adults and the ear lobe in children. Borrelial lymphocytoma is frequently associated with erythema migrans,...
Tuesday 4 October 2022
Lyme disease is becoming increasingly common across the world, with warming temperatures one possible culprit for ticks spreading to new regions (Source: New Scientist - Health)
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Tuesday 4 October 2022
Am J Clin Pathol. 2022 Aug 10:aqac080. doi: 10.1093/ajcp/aqac080. Online ahead of print.NO ABSTRACTPMID:35946458 | DOI:10.1093/ajcp/aqac080 (Source: American Journal of Clinical Pathology)
Tuesday 4 October 2022
A 23-year-old man presented with new onset horizontal diplopia 5 months after a left orbital floor fracture. Examination revealed bilateral abduction deficits and disc swelling. Urgent MRI and MRI showed no significant abnormalities in the CNS. Lumbar puncture revealed a minimally elevated opening pressure and significant leukocytosis. Additional CSF testing revealed probable Lyme meningitis. The patient responded to a course of oral doxycycline, with rapid resolution of his diplopia, abduction deficits, and disc edema. (Source: Survey of Ophthalmology)
Tuesday 4 October 2022
ConclusionsThese findings serve as a solid basis for regionally tailored population-based intervention programmes and can support modelling studies assessing the development of LB epidemiology under various climate change scenarios. (Source: Eurosurveillance)
Tuesday 4 October 2022
Table of contents A version of this story appeared in Science, Vol 376, Issue 6599. Download PDF ASTRONOMY Star mapper provides Milky Way portrait he European Space Agency’s Gaia satellite has now mapped almost 2 billion of the Milky Way’s stars, logging their positions, speeds, temperatures, and other parameters—and allowing astronomers to chart the Galaxy’s structure and evolution. Last week, operators released the third major trove of data, including lists of 800,000 binary stars, 10 million variable stars, and, within the Solar System, 156,000 asteroids and rocky bodies. Launched in 2013, Gaia has already uncovered new nearby satellite galaxies, fast-moving stars escaping the Milky Way, and evidence of past ga...
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Tuesday 4 October 2022
A 36-year-old Spanish man, with a background of ketamine use, presented with a 10-day history of severe headache, photophobia, nausea, unsteadiness and slurring of speech. His CT head was normal. CSF white cell count was 151 (lymphocytes), protein 0.7, glucose 2.3 (serum 3.6). He was treated with IV acyclovir for two weeks with no clinical improvement. On examination he remained distressed by headache and photophobic with severe dysarthria, bidirec- tional nystagmus and ataxia. Blood tests were normal or negative including HIV, serology for syphilis, mycoplasma, lyme and brucella, ANA, ENA, dsDNA, ANCA, ACE, LGI1 and NMDA antibodies, anti-Hu, Ri and Yo. IGRA was positive. MRI brain scan was normal. Serial lumbar punctures showed a variable CSF white cell count, with a negative extended vir...
Tuesday 4 October 2022
Conclusions Bilateral facial nerve palsy is an extremely rare condition with a varied etiology. Electrodiagnostic studies are useful in detecting the underlying pathophysiologic processes, prognosis, and central or peripheral lesion localization in patients with facial diplegia.PMID:35719795 | PMC:PMC9200109 | DOI:10.7759/cureus.25047 (Source: Herpes)
Tuesday 4 October 2022
ConclusionsThese findings serve as a solid basis for regionally tailored population-based intervention programmes and can support modelling studies assessing the development of LB epidemiology under various climate change scenarios.PMID:35959689 | DOI:10.2807/1560-7917.ES.2022.27.32.2101193 (Source: Euro Surveill)
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Tuesday 4 October 2022
Conclusions Bilateral facial nerve palsy is an extremely rare condition with a varied etiology. Electrodiagnostic studies are useful in detecting the underlying pathophysiologic processes, prognosis, and central or peripheral lesion localization in patients with facial diplegia.PMID:35719795 | PMC:PMC9200109 | DOI:10.7759/cureus.25047 (Source: Herpes)
Tuesday 4 October 2022
CONCLUSION: Our study suggested that TLR6, ANGPT1, LDLR, SREBF1, TNC, and ITGA may be candidate mammal biomarkers for LNB, and the TLR6/PI3K-Akt signaling pathway may play an important role in LNB pathogenesis.PMID:35964914 | DOI:10.1016/j.meegid.2022.105349 (Source: Infection, Genetics and Evolution)
Tuesday 4 October 2022
AbstractA 34-year-old road builder was admitted to the authors’ emergency department due to progressive dyspnoea that had been present for 6 days. The patient had a history of excessive smoking (60 cigarettes/day). The medical history was otherwise unremarkable. A transient rash had occurred during wo rk 2 weeks previously. The patient could not remember a bite. The electrocardiogram showed 2:1 atrioventricular (AV) block with narrow QRS complexes. D‑dimer and C‑reactive protein were slightly elevated; all other laboratory findings were within normal range. Echocardiography revealed normal findings. ELISA and western blot analysis confirmed acute Lyme disease. Cardiac magnetic resonance imaging (MRI) disclosed myocardial edema in the interventricular septum. Antibiotic treatm...
Tuesday 4 October 2022
Purpose of review The first convincing evidence for a causal relationship between bacterial infection and lymphomagenesis came from the link between gastric lymphoma and chronic Helicobacter pylori gastritis. This review will summarize the current epidemiological, clinical, and biological evidence of a causative role of bacteria in the development of malignant lymphomas, particularly, the extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue type. Recent findings Other microorganisms have been associated with specific extranodal lymphoma sites with variable and not always definitive, evidence, including Chlamydia psittaci, Borrelia burgdorferi, Campylobacter jejuni and, most recently, Coxiella Burnetii. According to most plausible models, lymphoma growth is a co...
Tuesday 4 October 2022
CMAJ Open. 2022 Jun 28;10(2):E570-E576. doi: 10.9778/cmajo.20210063. Print 2022 Apr-Jun.ABSTRACTBACKGROUND: Despite increases in cases of Lyme disease, little is known about the management and clinical course of the disease in Canada. We aimed to describe the management and clinical course of Lyme disease in patients treated in acute care facilities in Quebec and to assess adherence to the 2006 Infectious Diseases Society of America (IDSA) guideline.METHODS: This retrospective multicentre cohort study included pediatric and adult patients with serologically confirmed Lyme disease treated in acute care facilities (12 community hospitals and 2 tertiary care centres) of 2 endemic regions of Quebec (Estrie and Montérégie), from 2004 to 2017. We considered drug choice, prescribed dose and tre...
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Tuesday 4 October 2022
We present the case of a 63-year-old female unvaccinated against COVID-19. She presented with fever, cough, shortness of breath, and rash. The symptoms were present for four days and appeared after contact with a confirmed symptomatic COVID-19-positive family member. The rash started first on the chest and then spread to the face and whole body including the palms and soles. It was erythematous and maculopapular and is associated with ulceration and swelling of the lips. In places, it was confluent and had a target-like appearance. On admission, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) polymerase chain reaction (PCR) was negative. As she was septic with initial suspicion of tick-borne infections, she was started on doxycycline. Given her symptoms on presentation, th...
Tuesday 4 October 2022
Infection and Immunity, Ahead of Print. (Source: Infection and Immunity)
Tuesday 4 October 2022
Florid lymphoid hyperplasias of the lower female genital tract, also known as pseudolymphoma or lymphoma-like lesions, are benign lesions displaying histologic features which mimic aggressive B-cell lymphomas. Initially described by Young and colleagues in 1985, fewer than 100 cases have been published, making this lesion rather uncommon and subject to misdiagnoses. However, given that this entity has now been included in the World Health Organization’s most recent classification, greater clarity would be beneficial for pathologists and physicians. Thus, our report aims to review these entities and provide all available data. We reviewed the available literature according to PRISMA guidelines. We found that lymphoma-like lesions, regardless of their localization, display numerous superfi...
Tuesday 4 October 2022
Acta Trop. 2022 Jul 1:106586. doi: 10.1016/j.actatropica.2022.106586. Online ahead of print.ABSTRACTEnvironmental changes, due to climatic emergency and to anthropogenic activities severely impact on the epidemiology of vector borne diseases, mostly when transmitted by ticks. The data about the distribution of microorganisms responsible for them in roe deer (Capreolus capreolus) population living in Italy are scanty and completely lacking in Tuscany, so a molecular survey was carried out to estimate the prevalence of some zoonotic tick-borne pathogens in roe deer, and ticks removed from them, living in areas of Central Italy with high risk of arthropod exposure. Spleen samples from 72 roe deer were tested by PCR for Anaplasma phagocytophilum, Borrelia burgdorferi s.l., Francisella tularens...
Tuesday 4 October 2022
Clin Exp Immunol. 2022 Aug 24:uxac073. doi: 10.1093/cei/uxac073. Online ahead of print.ABSTRACTPrevious studies have shown that monocytes can be 'trained' or tolerized by certain stimuli to respond stronger or weaker to a secondary stimulation. Rewiring of glucose metabolism was found to be important in inducing this phenotype. As we previously found that Borrelia burgdorferi (B. burgdorferi), the causative agent of Lyme borreliosis (LB), alters glucose metabolism in monocytes, we hypothesized that this may also induce long-term changes in innate immune responses. We found that exposure to B. burgdorferi decreased cytokine production in response to the TLR4-ligand lipopolysaccharide (LPS). In addition, B. burgdorferi exposure decreased baseline levels of glycolysis, as assessed by lactate ...
Tuesday 4 October 2022
Lyme disease is caused by Borrelia burgdorferi, and the pathogenesis of the disease is complex with both bacterial and host factors contributing to inflammatory responses. Lyme disease affects different organs including joints and results in arthritis. Immune responses stimulated by B. burgdorferi through toll-like receptors cause infiltration of leukocytes, which produce inflammatory cytokines and facilitate spirochete clearance. However, arthritic manifestations and chronic fatigue syndrome-like symptoms persist long after completion of antibiotic treatment regimens in a significant number of patients. To counter the effects of inflammation, treatment by non-steroidal anti-inflammatory drugs, hydroxychloroquine, or synovectomy to eradicate inflammatory arthritis in the involved joint cou...
Tuesday 4 October 2022
Parasites can alter host and vector phenotype and thereby affect ecological processes in natural populations. Laboratory studies have suggested that Borrelia burgdorferi sensu lato, the causative agent of human L... (Source: BMC Evolutionary Biology)
Tuesday 4 October 2022
Borrelia burgdorferi, the Lyme disease pathogen, is maintained in its enzootic life cycle through complex gene regulatory pathways encoded on its uniquely fragmented genome. This genome consists of over 20 plasmids, and the regulatory mechanisms of plasmid maintenance and replication are largely unknown. The bbd21 gene, encoded on lp17 and a member of the paralogous family 32 proteins, was originally proposed to be a putative parA orthologue involved with plasmid partitioning; however, this function has not been confirmed to date. To determine the role of bbd21 in B. burgdorferi, we utilized targeted gene deletion and discovered bbd21 and bbd22 are co-transcribed. The effects of bbd21 and bbd22 deletion on plasmid copy number and mammalian infectivity were assessed. By qPCR, lp17 copy numb...
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Tuesday 4 October 2022
Early disseminated Lyme disease can involve the peripheral or central nervous system, but with early diagnosis and treatment, prognosis for full recovery is excellent. The typical clinical presentations of neuroborreliosis are highlighted, and an approach to diagnosis and treatment is described. (Source: Infectious Diseases Clinics of North America)
Tuesday 4 October 2022
Small fiber neuropathy (SFN) has been associated with posttreatment Lyme disease syndrome (PTLDS), a chronic widespread pain condition with an enormous impact on quality of life. SFN has been associated with hyperalgesia and allodynia, as seen in fibromyalgia. In PTLDS, peripheral and central pain mechanisms involving SFN are likely present, with neuropeptide imbalance, leading to increased nociceptive signaling. Refractory SFN cases are challenging to manage, and Botulinum toxin type-A (BTX-A) could be a treatment option with long-lasting results and fewer side effects. (Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics)
Tuesday 4 October 2022
This article will review the reasons for these misunderstandings and the arguments against them. (Source: Infectious Diseases Clinics of North America)
Tuesday 4 October 2022
Abstract: Lyme borreliosis (LB) is the most common tick-borne infection in Europe and North America. Polymerase chain reaction (PCR) is an important tool to confirm the diagnosis, but not always successful, especially when organisms are sparse. We developed a novel, seminested real-time PCR assay [target: 5S-23S intergenic spacer region (IGS)] and compared it with 3 well-established conventional PCR assays (IGS/OspA/real-time IGS) on 596 formalin-fixed, paraffin-embedded routine skin biopsies. The seminested real-time assay identified 46 cases of borreliosis while 25, 27, and 38 were identified by the 3 other assays, respectively (P 0.01, P 0.02, and P 0.42; significance P (Source: The American Journal of Dermatopathology)
Tuesday 4 October 2022
Lyme carditis is an uncommon manifestation of Lyme disease. Most cases present with heart block of varying degrees, but the spectrum of disease includes other transient arrhythmias and structural manifestations, such as myopericarditis or cardiomyopathy. Antibiotics hasten the resolution of Lyme carditis, and cardiac pacing can be an adjunctive therapy. Outcomes are generally good, but there are rare fatalities associated with Lyme carditis. The latter underscores the continued need for improved modes of prevention of Lyme disease and the importance of its early recognition and treatment. (Source: Infectious Diseases Clinics of North America)
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Tuesday 4 October 2022
To estimate the incidence of scleritis in Lyme disease and report clinical features. (Source: American Journal of Ophthalmology)
Tuesday 4 October 2022
Lyme disease is now the most frequently reported vector-borne disease in the United States. The highest incidence is in children aged 5 to 9 years with a male predominance. The most common manifestation, erythema migrans, is sometimes not recognized, leading to risk of complications. Testing for Lyme disease should only be done if there is a consistent clinical syndrome with exposure in a Lyme-endemic area. Most forms of Lyme disease a re successfully treated with short courses of oral therapy. Prevention and management of tick bites is important. (Source: Infectious Diseases Clinics of North America)
Tuesday 4 October 2022
Acta Trop. 2022 May 3:106502. doi: 10.1016/j.actatropica.2022.106502. Online ahead of print.ABSTRACTDogs are commonly exposed to vector-borne pathogens (VBPs), yet few data are available on hunting dogs, which are often at high risk of infection due to their involvement in field activities. To investigate the occurrence of VBPs and evaluate the relative performance of different diagnostic tools, blood and serum samples were collected from hunting dogs (n = 1,433) in rural areas of southern Italy. All samples were tested by Knott's technique for filarioids, serologically (SNAP® 4Dx® Plus) for Anaplasma spp., Borrelia burgdorferi sensu lato, Dirofilaria immitis and Ehrlichia spp. and molecularly (qPCR) for all except B. burgdorferi of the above pathogens plus Babesia spp. and Leishmania in...
Tuesday 4 October 2022
Lyme disease is the most common vector-borne illness in North America and Europe. The etiologic agent, Borrelia burgdorferi sensu lato, is transmitted to humans by certain species of Ixodes ticks, which are found widely in temperate regions of the Northern hemisphere. Clinical features are diverse but death is rare. The risk of human infection is determined by the distribution and abundance of vector ticks, ecologic factors influencing tick infection rates, and human behaviors that promote tick bite. Rates of infection are highest among children aged 5 to 15 years and adults aged more than 50 years. In the northeastern United States where disease is most common, exposure occurs primarily in areas immediately around the home. Knowledge of disease epidemiology is important for patient mana...
Tuesday 4 October 2022
Curr Opin Immunol. 2022 May 9;77:102187. doi: 10.1016/j.coi.2022.102187. Online ahead of print.ABSTRACTInfection of mice with Borrelia burgdorferi (Bb), a tick-transmitted spirochete and the pathogen that causes Lyme disease in humans, triggers CD4 T cell activation in secondary lymphoid tissues, from which they disseminate into various infected tissues. Despite their activation and the appearance of CD4 T cell-dependent antibody responses, Bb establishes persistent infection in natural Bb reservoir hosts in the absence of overt disease, raising the question of the effectiveness of the anti-Bb T cell responses. Reviewing the existing literature, we propose that CD4 T cells might constitute a host cell target of Bb-mediated immune evasion, rendering these cells ineffective in orchestrating ...
Tuesday 4 October 2022
Erythema migrans, an expanding erythematous skin lesion that develops days to weeks following an Ixodes species tick bite, is the most common clinical manifestation of Lyme disease. Presentations in the United States differ somewhat from that in Europe, presumably because of the different etiologic agents. Diagnosis is based on the appearance of the skin lesion, rather than on laboratory testing. After treatment with an appropriate oral antibiotic for 10 to 14 days, the prognosis is excellent. Two conditions that cause a similar skin lesion following a tick bite, but are of unknown cause, are Southern tick-associated rash illness in the United States and tick-associated rash illness in Japan. (Source: Infectious Diseases Clinics of North America)
Tuesday 4 October 2022
AbstractA 35-year-old Caucasian woman presented an abrupt onset of bilateral impaired vision, and arrived to our attention two weeks later. She had a previous episode of mild dizziness. She underwent a fluorescein angiography showing branch retinal artery occlusions and a brain magnetic resonance imaging (MRI) revealing several supraand infratentorial FLAIR-hyperintense white matter lesions, two with contrast enhancement. Thrombophilic, autoimmune and infective (including Human Immunodeficiency Virus, Borrelia burgdorferi, Hepatitis B Virus, Hepatitis C Virus, Herpes Simplex Virus 1-2, Varicella Zoster Virus) screening was negative. Cerebrospinal fluid analysis showed intrathecal IgG synthesis. We suspected a Primary Central Nervous System Vasculitis, and intravenous steroids were started....
Tuesday 4 October 2022
Arthritis is the most common late manifestation of Borrelia burgdorferi infection in the United States, usually beginning months after the tick bite. In most patients with Lyme arthritis (LA) today, arthritis is the presenting manifestation of the disease. Patients have swelling and pain in one or a few large joints, especially the knee. Serologic testing is the mainstay of diagnosis. Responses to antibiotic treatment are generally excellent, although a small percentage of patients have persistent, postinfectious synovitis after 2 to 3 months of oral and IV antibiotics, which respond to anti-inflammatory therapies. Herein we review the clinical presentation, diagnosis, and management of LA. (Source: Infectious Diseases Clinics of North America)
Tuesday 4 October 2022
Emerg Infect Dis. 2022 Jun;28(6):1292-1294. doi: 10.3201/eid2806.220443.ABSTRACTIn July 2021, a PCR-confirmed case of locally acquired Babesia microti infection was reported in Atlantic Canada. Clinical features were consistent with babesiosis and resolved after treatment. In a region where Lyme disease and anaplasmosis are endemic, the occurrence of babesiosis emphasizes the need to enhance surveillance of tickborne infections.PMID:35608954 | DOI:10.3201/eid2806.220443 (Source: Emerging Infectious Diseases)
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Tuesday 4 October 2022
Standard 2-tier testing (STTT), incorporating a screening enzyme immunoassay (EIA) or an immunofluorescence assay (IFA) that reflexes to IgM and IgG immunoblots, has been the primary diagnostic test for Lyme disease since 1995. In 2019, the Food and Drug Administration approved a modified 2-tier test strategy using 2 EIAs: offering a faster, less expensive, and more sensitive assay compared with STTT. New technologies examine early immune responses to Borrelia burgdorferi have the potential to diagnose Lyme disease in the first weeks of infection when existing serologic testing is not recommended due to low sensitivity. (Source: Infectious Diseases Clinics of North America)
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Tuesday 4 October 2022
Emerg Infect Dis. 2022 Jun;28(6):1292-1294. doi: 10.3201/eid2806.220443.ABSTRACTIn July 2021, a PCR-confirmed case of locally acquired Babesia microti infection was reported in Atlantic Canada. Clinical features were consistent with babesiosis and resolved after treatment. In a region where Lyme disease and anaplasmosis are endemic, the occurrence of babesiosis emphasizes the need to enhance surveillance of tickborne infections.PMID:35608954 | DOI:10.3201/eid2806.220443 (Source: Emerging Infectious Diseases)
Tuesday 4 October 2022
In North America, several hard tick-transmitted Borrelia species other than Borrelia burgdorferi cause human disease, including Borrelia miyamotoi, Borrelia mayonii, and possibly Borrelia bissettii. Due to overlapping clinical syndromes, nonspecific tickborne disease (TBD) testing strategies, and shared treatment approaches, infections with these lesser known Borrelia are likely under-reported. In this article, we describe the epidemiology, clinical manifestations, diagnosis, and treatment of these less common Borrelia pathogens. (Source: Infectious Diseases Clinics of North America)
Tuesday 4 October 2022
Pathogens that traffic in the blood of their hosts must employ mechanisms to evade the host innate immune system, including the complement cascade. The Lyme disease spirochete, Borreliella burgdorferi, has evolved numerous outer membrane lipoproteins that interact directly with host proteins. Compared to Lyme disease-associated spirochetes, relatively little is known about how an emerging tick-borne spirochetal pathogen, Borrelia miyamotoi, utilizes surface lipoproteins to interact with a human host. B. burgdorferi expresses the multifunctional lipoprotein, BBK32, that inhibits the classical pathway of complement through interaction with the initiating protease C1r, and also interacts with fibronectin using a separate intrinsically disordered domain. B. miyamotoi encodes two separate bbk32...
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Tuesday 4 October 2022
A consultation regarding Lyme disease can be challenging for the infectious disease physician when the referral question centers on the use of prolonged or empirical antibiotic treatment of Lyme disease and associated tick-borne infections. Patients who have been infected with Borrelia burgdorferi, and many who have been misdiagnosed, are confronted with a seemingly endless array of misinformation that is not in keeping with the current understanding of the clinical spectrum of Lyme disease and its response to evidence-based treatment. Preparing for these conversations with a good grasp of the public beliefs regarding Lyme disease and its treatment can be beneficial. (Source: Infectious Diseases Clinics of North America)
Tuesday 4 October 2022
A man, currently aged 72, developed a spastic paraparesis without sensory abnormalities progressing to wheel-chair dependence and late urinary incontinence over 14 years. Apart from a history of type 2 diabetes mellitus, he was otherwise well. Extensive blood and CSF investigations including screening for HIV, HTLV1, syphilis, and Lyme disease were normal or negative. There was no evidence of neuropathy or denervation on EMG. MRI showed mild non-specific white matter signal change in both cerebral hemi- spheres. A provisional diagnosis of primary lateral sclerosis (PLS) was revised with the finding of elevated Very Long Chain Fatty Acids (VLCFAs). Genetic testing revealed a novel missense variant c.1771C>G p. (Arg591Gly) in exon 7 of the ABCD1 gene. Mutation in ABCD1 transporter leads t...
Tuesday 4 October 2022
Most patients with Lyme disease will fully recover with recommended antibiotic therapy. However, some patients report persisting nonspecific symptoms after treatment, referred to as posttreatment Lyme disease symptoms (PTLDs) or syndrome (PTLDS), depending on the degree to which the individual ’s symptoms impact their quality of life. PTLDs occur in a portion of patients diagnosed with chronic Lyme disease (CLD), a controversial term describing different patient populations, diagnosed based on unvalidated tests and criteria. Practitioners should review the evidence for the Lyme disease diagnosis and not overlook unrelated conditions. Current evidence shows that prolonged antibiotic therapy provides little benefit and carries significant risk. Further research to elucidate the mechanisms ...
Tuesday 4 October 2022
by Patrick Pearson, Olivia Skaltsis, Chu-Yuan Luo, Guang Xu, Zachary Oppler, Dustin Brisson, Stephen M. RichBorrelia burgdorferi is an important tickborne human pathogen comprising several strains based on nucleotide sequence of the outer surface protein C (ospC) gene. Detection and characterization of differentospC genotypes is vital for research onB.burgdorferi and the risk it poses to humans. Here we present a novel, multiplex assay based on Luminex xMAP technology for the detection ofB.burgdorferi ospC genotypes. The assay has five major steps: amplification of theospC gene, hydrolyzation of surplus primers and nucleotides, incorporation of biotinylated nucleotides into the template DNA, hybridization to Luminex microspheres, and detection of fluorescent signals corresponding to eachos...
Tuesday 4 October 2022
Tick-borne diseases are a growing public health concern across much of North America.1 Black-legged ticks, in particular, continue their range of expansion in the northeast and upper midwestern United States, bringing with them an impressive list of human pathogens. Dr Mead puts the consequences of this phenomenon into context in our first article, entitled, “Epidemiology of Lyme disease.” East of the Mississippi, the vector tick Ixodes scapularis, commonly called the deer tick, may transmit seven different pathogens. (Source: Infectious Diseases Clinics of North America)
Tuesday 4 October 2022
CONCLUSION: Central themes found in CLD patients' communication are 1. the experience of significant symptoms, 2. for which adequate relief is only rarely found from conventional medical practitioners, and 3. that are largely invisible to the outside world. Verbalizing these themes, patients use various repertoires for their shared experiences, such as a feeling of abandonment or not being heard by the medical system, feelings of loss with respect to their previous health, and the idea that they might have been better off had they been diagnosed sooner. Working with these repertoires will enable healthcare providers to establish a shared perspective with their CLD patients, thus engaging in more fruitful doctor-patient communication. We hypothesize that these findings are not unique to CLD...
Tuesday 4 October 2022
INFECTIOUS DISEASE CLINICS OF NORTH AMERICA (Source: Infectious Diseases Clinics of North America)
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Tuesday 4 October 2022
CONCLUSION: Central themes found in CLD patients' communication are 1. the experience of significant symptoms, 2. for which adequate relief is only rarely found from conventional medical practitioners, and 3. that are largely invisible to the outside world. Verbalizing these themes, patients use various repertoires for their shared experiences, such as a feeling of abandonment or not being heard by the medical system, feelings of loss with respect to their previous health, and the idea that they might have been better off had they been diagnosed sooner. Working with these repertoires will enable healthcare providers to establish a shared perspective with their CLD patients, thus engaging in more fruitful doctor-patient communication. We hypothesize that these findings are not unique to CLD...
Tuesday 4 October 2022
We describe a case of a 56-year-old man with recent tick exposure who presented in atrial flutter with variable atrioventricular block after 3 days of fever, chills, and arthralgias. The patient was successfully treated and stably returned to sinus rhythm after initiation of antibiotics without cardioversion and was found to be positive for A. phagocytophilum but negative for Lyme disease. To our knowledge, this represents the first reported case of anaplasmosis-associated atrial flutter. As infections increase in incidence, clinicians in endemic areas should be aware of the potential manifestations and treatment considerations of tick-borne carditis. (Source: Infectious Diseases in Clinical Practice)
Tuesday 4 October 2022
Ixodid ticks are important vectors for zoonotic pathogens, with Ixodes ricinus being the most important in Europe. Rodents are hosts of immature life stages of I. ricinus ticks and are considered main reservoirs ... (Source: Parasites and Vectors)
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Tuesday 4 October 2022
Trends Microbiol. 2022 Aug 30:S0966-842X(22)00214-1. doi: 10.1016/j.tim.2022.08.002. Online ahead of print.ABSTRACTTick-transmitted bacterial pathogens thrive in enzootic infection cycles, colonizing disparate vertebrate and arthropod tissues, often establishing persistent infections. Therefore, the evolution of robust immune evasion strategies is central to their successful persistence or transmission between hosts. To survive in nature, these pathogens must counteract a broad range of microbicidal host responses that can be localized, tissue-specific, or systemic, including a mix of these responses at the host-vector interface. Herein, we review microbial immune evasion strategies focusing on Lyme disease spirochetes and rickettsial or tularemia agents as models for extracellular and int...
Tuesday 4 October 2022
A 23-year-old man presented with new onset horizontal diplopia 5 months after a left orbital floor fracture. Examination revealed bilateral abduction deficits and disc swelling. Urgent MRI and MRI showed no significant abnormalities in the CNS. Lumbar puncture revealed a minimally elevated opening pressure and significant leukocytosis. Additional CSF testing revealed probable Lyme meningitis. The patient responded to a course of oral doxycycline, with rapid resolution of his diplopia, abduction deficits, and disc edema. (Source: Survey of Ophthalmology)
Tuesday 4 October 2022
CONCLUSION: Rickettsiosis is unlikely as a common cause of facial palsy in Southern Jutland, Denmark.FUNDING: The study was supported financially by the Knud and Edith Eriksen Mindefond and the Region of Southern Denmark.TRIAL REGISTRATION: The study population and the control group were approved by the Regional Committees on Health Research Ethics for Southern Denmark (S-20170136 and S-20170049) and by the Danish Data Protection Agency (17/31901 and 18/28928). All participants provided informed consent before their enrollment in the study.PMID:36065885 (Source: Danish Medical Journal)
Tuesday 4 October 2022
CONCLUSIONS: When used concurrently with serologic testing, WB-RTPCR testing increases diagnostic sensitivity in cases of ELD.PMID:35723600 | DOI:10.1093/ajcp/aqac068 (Source: American Journal of Clinical Pathology)
Tuesday 4 October 2022
Genes doi: 10.3390/genes13091604 Authors: Kayla M. Socarras Benjamin S. Haslund-Gourley Nicholas A. Cramer Mary Ann Comunale Richard T. Marconi Garth D. Ehrlich The acceleration of climate change has been associated with an alarming increase in the prevalence and geographic range of tick-borne diseases (TBD), many of which have severe and long-lasting effects—particularly when treatment is delayed principally due to inadequate diagnostics and lack of physician suspicion. Moreover, there is a paucity of treatment options for many TBDs that are complicated by diagnostic limitations for correctly identifying the offending pathogens. This review will focus on the biology, disease pathology, and detection methodologies used for the Borreliaceae family which incl...
Tuesday 4 October 2022
Vector-Borne and Zoonotic Diseases, Ahead of Print. (Source: Vector-Borne and Zoonotic Diseases)
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Tuesday 4 October 2022
(Source: Journal of AAPOS)
Tuesday 4 October 2022
Lyme borreliosis is the most prevalent vector-borne disease in Europe, and numbers might increase due to climate change. However, borreliosis is not notifiable in North Rhine-Westphalia (NRW), Germany. Hence, ... (Source: Parasites and Vectors)
Tuesday 4 October 2022
CMAJ. 2022 Sep 12;194(35):E1218-E1220. doi: 10.1503/cmaj.220112-f.NO ABSTRACTPMID:36096504 | PMC:PMC9477248 | DOI:10.1503/cmaj.220112-f (Source: Canadian Medical Association Journal)
Tuesday 4 October 2022
CONCLUSION: The study reveals that IgG-seropositivity for Borrelia burgdorferi in Eastern Slovakia is predominant in men and occurs mainly in rural areas. The findings also suggest that exposure to Borrelia burgdorferi (with subsequent antibody response in serum) does occur, mostly without giving rise to clinical Lyme borreliosis.PMID:35841220 | DOI:10.21101/cejph.a6808 (Source: Central European Journal of Public Health)
Tuesday 4 October 2022
CMAJ. 2022 Sep 12;194(35):E1232. doi: 10.1503/cmaj.220945-f.NO ABSTRACTPMID:36096507 | PMC:PMC9477254 | DOI:10.1503/cmaj.220945-f (Source: Canadian Medical Association Journal)
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Tuesday 4 October 2022
In this study, we used data-dependent acquisition to key pathogen protein signatures in black-legged ticks collected from the Southern Tier New York. Bottom-up proteomic analysis of extract from five combined ticks identified 2,052 tick proteins and 41 pathogen proteins with high confidence (≥ 99% C.I.). Results show high peptide spectral match counts for Rickettsia species and Borrelia species and lower counts for other rarer pathogens such as Anaplasma phagocytophilum. Parallel reaction monitoring performed on protein extracts from individual ticks (n = 10) revealed that 8 out of the 10 screened ticks carried Rickettsia species, 5 carried Borrelia species, 3 carried both pathogens, and only 1 tick carried no detectable bacteria. Mass spectrometry-based proteomics is a highly specific w...
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Tuesday 4 October 2022
CMAJ. 2022 Sep 12;194(35):E1218-E1220. doi: 10.1503/cmaj.220112-f.NO ABSTRACTPMID:36096504 | PMC:PMC9477248 | DOI:10.1503/cmaj.220112-f (Source: Canadian Medical Association Journal)
Tuesday 4 October 2022
Lyme disease is an infectious disease caused by bacteria of theBorrelia burgdorferisensu lato(Bbsl) complex and is characterized by predominant lesions of the skin, cardiovascular system, nervous system and musculoskeletal system. We have described a clinical case of first-degree atrioventricular block in a 14-year-old boy caused by Lyme borreliosis. The disease started with the manifestations of cardiovascular system involvement. The patient and his parents did not recall observing a tick bite or manifestation of erythema migrans (EM). The boy was prescribed doxycycline. Three weeks after antibiotic therapy a second ECG examination was performed and showed no abnormalities. (Source: The Journal of Infection in Developing Countries)
Tuesday 4 October 2022
CMAJ. 2022 Sep 12;194(35):E1232. doi: 10.1503/cmaj.220945-f.NO ABSTRACTPMID:36096507 | PMC:PMC9477254 | DOI:10.1503/cmaj.220945-f (Source: Canadian Medical Association Journal)
Tuesday 4 October 2022
S. A. Hook et al. (Source: Emerging Infectious Diseases Journal)
Tuesday 4 October 2022
CMAJ. 2022 Sep 12;194(35):E1218-E1220. doi: 10.1503/cmaj.220112-f.NO ABSTRACTPMID:36096504 | PMC:PMC9477248 | DOI:10.1503/cmaj.220112-f (Source: Canadian Medical Association Journal)
Tuesday 4 October 2022
Emerg Infect Dis. 2022 Jun;28(6):1292-1294. doi: 10.3201/eid2806.220443.ABSTRACTIn July 2021, a PCR-confirmed case of locally acquired Babesia microti infection was reported in Atlantic Canada. Clinical features were consistent with babesiosis and resolved after treatment. In a region where Lyme disease and anaplasmosis are endemic, the occurrence of babesiosis emphasizes the need to enhance surveillance of tickborne infections.PMID:35608954 | DOI:10.3201/eid2806.220443 (Source: Emerging Infectious Diseases)
Tuesday 4 October 2022
CMAJ. 2022 Sep 12;194(35):E1232. doi: 10.1503/cmaj.220945-f.NO ABSTRACTPMID:36096507 | DOI:10.1503/cmaj.220945-f (Source: Canadian Medical Association Journal)
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Tuesday 4 October 2022
Emerg Infect Dis. 2022 Jun;28(6):1292-1294. doi: 10.3201/eid2806.220443.ABSTRACTIn July 2021, a PCR-confirmed case of locally acquired Babesia microti infection was reported in Atlantic Canada. Clinical features were consistent with babesiosis and resolved after treatment. In a region where Lyme disease and anaplasmosis are endemic, the occurrence of babesiosis emphasizes the need to enhance surveillance of tickborne infections.PMID:35608954 | DOI:10.3201/eid2806.220443 (Source: Emerging Infectious Diseases)
Tuesday 4 October 2022
CMAJ. 2022 Sep 12;194(35):E1218-E1220. doi: 10.1503/cmaj.220112-f.NO ABSTRACTPMID:36096504 | DOI:10.1503/cmaj.220112-f (Source: Canadian Medical Association Journal)
Tuesday 4 October 2022
IJERPH, Vol. 19, Pages 6516: Climate Changes Exacerbate the Spread of Ixodes ricinus and the Occurrence of Lyme Borreliosis and Tick-Borne Encephalitis in Europe—How Climate Models Are Used as a Risk Assessment Approach for Tick-Borne Diseases International Journal of Environmental Research and Public Health doi: 10.3390/ijerph19116516 Authors: Chrysa Voyiatzaki Sevastiani I. Papailia Maria S. Venetikou John Pouris Maria E. Tsoumani Effie G. Papageorgiou Climate change has influenced the transmission of a wide range of vector-borne diseases in Europe, which is a pressing public health challenge for the coming decades. Numerous theories have been developed in order to explain how tick-borne diseases are associated with climate change. These theories include highe...
Tuesday 4 October 2022
CMAJ. 2022 Sep 12;194(35):E1232. doi: 10.1503/cmaj.220945-f.NO ABSTRACTPMID:36096507 | DOI:10.1503/cmaj.220945-f (Source: Canadian Medical Association Journal)
Tuesday 4 October 2022
CONCLUSION: Central themes found in CLD patients' communication are 1. the experience of significant symptoms, 2. for which adequate relief is only rarely found from conventional medical practitioners, and 3. that are largely invisible to the outside world. Verbalizing these themes, patients use various repertoires for their shared experiences, such as a feeling of abandonment or not being heard by the medical system, feelings of loss with respect to their previous health, and the idea that they might have been better off had they been diagnosed sooner. Working with these repertoires will enable healthcare providers to establish a shared perspective with their CLD patients, thus engaging in more fruitful doctor-patient communication. We hypothesize that these findings are not unique to CLD...
Tuesday 4 October 2022
CMAJ. 2022 Sep 12;194(35):E1218-E1220. doi: 10.1503/cmaj.220112-f.NO ABSTRACTPMID:36096504 | DOI:10.1503/cmaj.220112-f (Source: Canadian Medical Association Journal)
Tuesday 4 October 2022
In this study we collected ticks in popular recreational areas in the city of Vienna in the years 2019 and 2020 and analyzed them for the presence of such putative pathogenic microorganisms. By using reverse line blot (RLB) hybridization we detected DNA of B. burgdorferi s. l., Rickettsia spp., Babesia spp., Candidatus Neoehrlichia mikurensis (CNM) and Anaplasma phagocytophilum. Moreover, we also screened them for the relapsing fever spirochete Borrelia miyamotoi employing real-time PCR. The most frequently detected pathogens were B. burgdorferi s. l. in 28.6% of the ticks in 2019 and 21.3% of the ticks in 2020. The genus Rickettsia was detected in 13.8% of the ticks from 2019 and only in 4.6% from 2020. Babesia spp. were detected in 5.7% in 2019 and 4.2% in 2020. Furthermore, we detected ...
Tuesday 4 October 2022
CMAJ. 2022 Sep 12;194(35):E1232. doi: 10.1503/cmaj.220945-f.NO ABSTRACTPMID:36096507 | DOI:10.1503/cmaj.220945-f (Source: cmaj)
Tuesday 4 October 2022
CONCLUSIONS: When used concurrently with serologic testing, WB-RTPCR testing increases diagnostic sensitivity in cases of ELD.PMID:35723600 | DOI:10.1093/ajcp/aqac068 (Source: American Journal of Clinical Pathology)
Tuesday 4 October 2022
CMAJ. 2022 Sep 12;194(35):E1218-E1220. doi: 10.1503/cmaj.220112-f.NO ABSTRACTPMID:36096504 | DOI:10.1503/cmaj.220112-f (Source: cmaj)
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Tuesday 4 October 2022
(Source: European Journal of Clinical Microbiology and Infectious Diseases)
Tuesday 4 October 2022
CMAJ. 2022 Sep 12;194(35):E1232. doi: 10.1503/cmaj.220945-f.NO ABSTRACTPMID:36096507 | DOI:10.1503/cmaj.220945-f (Source: Canadian Medical Association Journal)
Tuesday 4 October 2022
Emerg Infect Dis. 2022 May;28(5):957-966. doi: 10.3201/eid2805.211146.ABSTRACTTickborne diseases (TBDs) such as Lyme disease result in ≈500,000 diagnoses annually in the United States. Various methods can reduce the abundance of ticks at small spatial scales, but whether these methods lower incidence of TBDs is poorly understood. We conducted a randomized, replicated, fully crossed, placebo-controlled, masked experiment to test whether 2 environmentally safe interventions, the Tick Control System (TCS) and Met52 fungal spray, used separately or together, affected risk for and incidence of TBDs in humans and pets in 24 residential neighborhoods. All participating properties in a neighborhood received the same treatment. TCS was associated with fewer questing ticks and fewer ticks feeding ...
Tuesday 4 October 2022
CMAJ. 2022 Sep 12;194(35):E1218-E1220. doi: 10.1503/cmaj.220112-f.NO ABSTRACTPMID:36096504 | DOI:10.1503/cmaj.220112-f (Source: cmaj)
Tuesday 4 October 2022
AbstractClimate change is adversely affecting the burden of infectious disease throughout the world, which is a health security threat. Climate-sensitive infectious disease includes vector-borne diseases such as malaria, whose transmission potential is expected to increase because of enhanced climatic suitability for the mosquito vector in Asia, sub-Saharan Africa, and South America. Climatic suitability for the mosquitoes that can carry dengue, Zika, and chikungunya is also likely to increase, facilitating further increases in the geographic range and longer transmission seasons, and raising concern for expansion of these diseases into temperate zones, particularly under higher greenhouse gas emission scenarios. Early spring temperatures in 2018 seem to have contributed to the early onset...
Tuesday 4 October 2022
In this study, low-dose methylprednisolone (0.8 mg/kg/day, MP) was used to induce a steroid-resistant lupus nephritis (SR-LN) mouse model in weeks one to four, and a therapeutic steroid dosage (MP 12 mg/kg/day) or a combined PNS (PNS 100 mg/kg/day) treatment was administered from week five to eight. Lymphocyte-derived exosomes (Lyme-Exos) were isolated from the spleens of mice and injected into untreated homozygous LN mice for 14 days via the tail vein. At the end of the experiment, the efficacy and mechanism of action of different groups of Lyme-Exos on LN mice were observed. The results revealed that exogenously injected Lyme-Exos were effectively taken up by the kidney and affected the progression of kidney disease. Steroid-resistant lymphocyte-derived exosomes intervented with PNS ...
Tuesday 4 October 2022
Emerg Infect Dis. 2022 Jun;28(6):1292-1294. doi: 10.3201/eid2806.220443.ABSTRACTIn July 2021, a PCR-confirmed case of locally acquired Babesia microti infection was reported in Atlantic Canada. Clinical features were consistent with babesiosis and resolved after treatment. In a region where Lyme disease and anaplasmosis are endemic, the occurrence of babesiosis emphasizes the need to enhance surveillance of tickborne infections.PMID:35608954 | DOI:10.3201/eid2806.220443 (Source: Emerging Infectious Diseases)
Tuesday 4 October 2022
Lyme borreliosis is a vector-borne disease caused by spirochaetes of the Borrelia burgdorferi (Bb) sensu lato complex [1]. Lyme borreliosis has various distinct symptom manifestations, and 10 –15% of European patients develop Lyme neuroborreliosis (LNB) [2]. (Source: Journal of Infection)
Tuesday 4 October 2022
CONCLUSION: We successfully developed a Multiplex PCR assay for differential diagnosis of rickettsiosis, Lyme disease and scrub typhus that could be a rapid and easy option in clinical and epidemiological practice.PMID:36124484 | DOI:10.4103/0972-9062.337506 (Source: Journal of Vector Borne Diseases)
Tuesday 4 October 2022
Infection and Immunity, Ahead of Print. (Source: Infection and Immunity)
Tuesday 4 October 2022
ConclusionWe describe an unusual steroid-responsive, longitudinally extensive spinal cord lesion with radiological features of spinal cord infarct and a simultaneous finding of intrathecal Lyme antibodies and serum amphiphysin antibodies. (Source: Frontiers in Neurology)
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Tuesday 4 October 2022
CMAJ. 2022 Sep 12;194(35):E1232. doi: 10.1503/cmaj.220945-f.NO ABSTRACTPMID:36096507 | DOI:10.1503/cmaj.220945-f (Source: cmaj)
Tuesday 4 October 2022
Borrelia burgdorferi sensu lato (BBSL), the causative agent of Lyme disease, is commonly found in wild and domestic mammals and ticks worldwide. In China, human cases of Borrelia burgdorferi infections have been identified across a wide geographic range including Yunnan Province, but few studies have examined BBSL in reservoirs and vectors in southwestern China. Here we conducted a thorough and broad-range investigation of BBSL in small mammals, domestic mammals, and ticks collected from 159 sample sites across 42 counties in Yunnan Province. DNA was extracted from spleen tissue of small mammals, blood from domestic mammals, and homogenized ticks. Nested PCR targeting the 5S-23S rRNA intergenic spacer gene of BBSL was used for screening, with amplicons sequenced directly and analyzed using...
Tuesday 4 October 2022
In this study, we experimentally characterized specific domains of P66 with regard to structure and function. First, we aligned the amino acid sequences of P66 from Lyme disease-causing Borrelia and relapsing fever-causing Borrelia to identify conserved and unique domains between these disease-causing clades. Then, we examined whether specific domains of P66 are exposed on the surface of the bacteria by introducing c-Myc epitope tags into each domain of interest. The c-Myc epitope tag inserted C-terminally to E33 (highly conserved domain), to T187 (integrin binding region domain and a non-conserved domain), and to E334 (non-conserved domain) were all detected on the surface of Borrelia burgdorferi. The c-Myc epitope tag inserted C-terminally to E33 and D303 in conserved domains disrupted P...
Tuesday 4 October 2022
(Source: Chemical and Engineering News)
Tuesday 4 October 2022
CONCLUSION: The results of the study illustrate that the topic "climate change and health" has a high relevance for paediatricians and that information measures for parents are considered to be effective. Although paediatricians are concerned with the topic, there is an implementation deficit. Support is needed in the form of intensifying awareness raising projects and educational modules for paediatricians to move from knowledge to action.PMID:35710526 | DOI:10.1016/j.zefq.2022.03.007 (Source: Zeitschrift fur Evidenz, Fortbildung und Qualitat im Gesundheitswesen)
Tuesday 4 October 2022
AbstractLyme borreliosis (LB) is the most common tick-borne infection in Europe, with Lyme neuroborreliosis (LNB) its second most frequent clinical manifestation. Prognostic factors for clinical outcomes in LNB have not been identified. Elevated serum levels of the brain damage markers neuron-specific enolase (NSE) and S100 calcium-binding protein B (S100B) have been associated with poor clinical outcomes in other disorders of the central nervous system. The aim of this study is to assess NSE and S100B in serum as prognostic biomarkers for clinical outcomes in paediatric LNB patients. Children evaluated for LNB (n = 121) in Sweden were prospectively included during 2010–2014, serum samples were collected on admission, and all children underwent a 2-month follow-up. Patients with pleo...
Tuesday 4 October 2022
CONCLUSION: Central themes found in CLD patients' communication are 1. the experience of significant symptoms, 2. for which adequate relief is only rarely found from conventional medical practitioners, and 3. that are largely invisible to the outside world. Verbalizing these themes, patients use various repertoires for their shared experiences, such as a feeling of abandonment or not being heard by the medical system, feelings of loss with respect to their previous health, and the idea that they might have been better off had they been diagnosed sooner. Working with these repertoires will enable healthcare providers to establish a shared perspective with their CLD patients, thus engaging in more fruitful doctor-patient communication. We hypothesize that these findings are not unique to CLD...
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Tuesday 4 October 2022
A 28 year-old Caucasian woman was found to have reduced visual acuity during routine optician checks and was referred to ophthalmology and then neurology. Examination revealed acuities of 6/12 in both eyes, pale optic discs and reduced colour perception. MRI brain did not show any lesions. Routine bloods were normal as were serum ACE, B1, B12, folate, HIV, syphilis, Lyme serology, AQP4-IgG and MOG-IgG. Leber’s and AD optic atrophy screens were negative. CSF protein was 0.41, WBC 7 (100% lymphocytes), elevated IgG Index 1.4 (normal<0.8),OCBs in serum and CSF with a single additional band raising the possibility of inflammatory optic neuritis. There was apparent stabilisation on empiric steroids which was then converted to steroid sparing immunosuppressants. However, as vision decli...
Thursday 29 September 2022
New Hampshire has signed into law a bill that establishes a commission to study the limitations of current testing for Lyme disease and other tick-borne illnesses and available treatment.Associated Press (Source: Medscape Infectious Diseases Headlines)
Thursday 29 September 2022
Insects can pass along serious illnesses, such as Lyme disease and West Nile virus. Because of covid-19, health agencies are focusing less on these problems. (Source: Washington Post: To Your Health)
Thursday 29 September 2022
Lyme and Covid-19 are replacing syphilis as the great masquerader. They share many puzzling symptoms and are all easily missed. (Source: Forbes.com Healthcare News)
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Thursday 29 September 2022
(Rutgers University) A tick species associated with bats has been reported for the first time in New Jersey and could pose health risks to people, pets and livestock, according to a Rutgers-led study in the Journal of Medical Entomology. This species (Carios kelleyi) is a " soft " tick. Deer ticks, which carry Lyme disease, are an example of " hard " ticks. (Source: EurekAlert! - Infectious and Emerging Diseases)
Thursday 29 September 2022
A few years ago, Jaime Seltzer was helping coordinate research projects, grant applications and funding for a Stanford research group studying a condition called myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Up to 2.5 million Americans, including Seltzer, have ME/CFS, and yet it felt like almost no one paid attention to her group’s research. “What is it going to take for researchers to take ME seriously?” she and her colleagues often wondered aloud. The morbid answer, they hypothesized, was a pandemic. Since ME/CFS often follows viral infections, they feared it would take something as destructive as mass illness for the larger scientific community to take notice. Unfortunately, this year they were proven right. As the COVID-19 pandemic presses on, doctors ...
Thursday 29 September 2022
(Yale University) Yale researchers have discovered a protein that helps protect hosts from infection with the tick-borne spirochete that causes Lyme Disease, a finding that may help diagnose and treat this infection, they report Nov. 11 in the journalPLOS Pathogens. (Source: EurekAlert! - Medicine and Health)
Thursday 29 September 2022
The coronavirus testing debacle, much like early Lyme testing, is a reminder that diagnostics aren't perfect.Undark (Source: Medscape Medical News Headlines)
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Thursday 29 September 2022
This updated toolkit provides background information on ticks, Lyme disease risk, how to improve awareness of ticks and mitigate against tick-borne diseases through the promotion of Public Health England's key message which is to'be tick aware'. (Source: Current Awareness Service for Health (CASH))
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Thursday 29 September 2022
BOSTON (CBS) — As Massachusetts continues to fight the coronavirus pandemic, the public has plenty of questions. Dr. Mallika Marshall answered some of those sent to WBZ-TV’s Facebook, Instagram and Twitter accounts. With the upcoming season, we already have troubles with ticks and Lyme disease and mosquitoes and their diseases. How is the coronavirus going to affect this problem? – Ken from north of Boston Coronavirus is not spread by mosquitoes or ticks, but you’re right, we still have to protect ourselves from insect-borne diseases like Lyme Disease and West Nile Virus. So I would do what we normally do to avoid these insects: use protective clothing and insect repellant and avoid the times of day and locations where they thrive. If I self-isolate for more than two ...
Thursday 29 September 2022
(Virginia Tech) The awards are designed to support established and up-and-coming scientists who have identified new and defined approaches to improve diagnostics or therapeutics for Lyme disease. (Source: EurekAlert! - Medicine and Health)
Thursday 29 September 2022
(Virginia Tech) With a $661,216 grant from the Steven& Alexandra Cohen Foundation, Brandon Jutras, an assistant professor of biochemistry in the Virginia Tech College of Agriculture and Life Sciences, will study Lyme arthritis, including the cellular component that contributes to it. (Source: EurekAlert! - Infectious and Emerging Diseases)
Thursday 29 September 2022
One element of Upstate's work on Lyme disease and ticks is it's wildly successful tick identification program. Since April, more than 13,000 ticks have been sent to Upstate, with nearly one-third carrying some sort of infectious disease. (Source: SUNY Upstate Medical)
Thursday 29 September 2022
As warm weather sends people outdoors, some are encountering tenacious pests. Ticks go for blood in the hardest-to-reach places on the human body and put you at risk for Lyme disease. Here's what you need to know about staying tick-safe. (Source: CNN.com - Health)
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Thursday 29 September 2022
Pasos para ayudar a prevenir las picaduras y las enfermedades. ... por: Sarah Elizabeth Adler, AARP, 14 de julio de 2020 | ... In English | Garrapatas: Son las peque ñas plagas que interrumpen la di... (Source: AARP.org News)
Thursday 29 September 2022
(Harvard Medical School) A $5 million donation to Harvard Medical School will propel Lyme disease research, education (Source: EurekAlert! - Medicine and Health)
Thursday 29 September 2022
WASHINGTON — Blood tests for the coronavirus could play a key role in deciding whether millions of Americans can safely return to work and school. But public health officials warn that the current “Wild West” of unregulated tests is creating confusion that could ultimately slow the path to recovery. More than 70 companies have signed up to sell so-called antibody tests in recent weeks, according to U.S. regulators. Governments around the world hope that the rapid tests, which typically use a finger-prick of blood on a test strip, could soon ease public restrictions by identifying people who have previously had the virus and have developed some immunity to it. But key questions remain: How accurate are the tests, how much protection is needed and how long will that protec...
Thursday 29 September 2022
(Cornell University) New Cornell-led research shows that inadequate funding is the main barrier to better surveillance and control of ticks, including the blacklegged tick, which spreads Lyme disease, the No. 1 vector-borne illness in the country. (Source: EurekAlert! - Biology)
Thursday 29 September 2022
App Helps Screen for Autism Spectrum Disorder Step It Up! : Get Active for Your Health Disruptive Leg Movement? : Managing Restless Legs Syndrome Protect Yourself From Lyme Disease Noisy Planet (Source: NIH News in Health)
Thursday 29 September 2022
DiscussionMusculoskeletal problems are common problems in pediatric practice with up to 15% of acute care visits being for this problem. Joint pain is a common concern for families but the differential diagnosis is extensive and needs thoughtful consideration. History is a key to discerning the potential diagnosis but also in guiding the physical examination and laboratory examination. Family history especially for systemic diseases should be considered. On physical examination all joints should be examined include sacroiliac and temporomandibular joints. Is this arthritis or arthralgia? Distinction between inflammatory and non-inflammatory joints is important. Joints with inflammation are painful or stiff after rest and improve with activity. Joints without inflammation are better afte...
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Thursday 29 September 2022
(Bloomberg) — There are four critical facets of pandemic prevention, according to Lee Hannah, senior scientist at Conservation International. Three of them make immediate sense against the backdrop of our current emergency: stockpile masks and respirators; have testing infrastructure ready; and ban the global wildlife trade, including the open animal markets where COVID-19 may have first infected people. His fourth recommendation is more grandiose: “Take care of nature.” The assault on ecosystems that allowed COVID-19 to jump from animals to humans went far beyond merchants hunting and selling rare wildlife. Biodiversity—that is, the health of the entire ecosystem—can restrain pathogens before they ever leave the wild. “We need to tell people right now t...
Thursday 29 September 2022
(Virginia Tech) Renowned tick immunobiologist Utpal Pal wants to adapt the rabies vaccination platform to produce antibodies that can protect against Borrelia burgdorferi, the bacteria responsible for Lyme disease. The intention is to apply this work to other tick-borne diseases in the future. (Source: EurekAlert! - Medicine and Health)
Thursday 29 September 2022
La enfermedad de Lyme est á proliferando. ¿Cómo puede prevenirla? ¿Cuáles son los síntomas y qué debe hacer si cree haberla contraído? (Source: FDA Center for Drug Evaluation and Research - What's New)
Thursday 29 September 2022
It ’s not just Covid-19. Pathogens once confined to nature are making their way into humans on a more regular basis. And it’s our fault. (Source: NYT Health)
Thursday 29 September 2022
Credit: United Nations By Thalif DeenUNITED NATIONS, Mar 24 2020 (IPS) When US President Donald Trump repeatedly characterized the fast-spreading COVID-19 as a “Chinese virus” last week, it prompted some white supremacists to resurrect an age old ethnic slur against Chinese and East Asians: the “Yellow Peril” which, in a bygone era, was touted as a xenophobic threat to the Western world. But Tendayi Achiume, UN Special Rapporteur on Contemporary Forms of Racism, Racial Discrimination and Xenophobia, is highly critical of the racist interpretation to a disease which has claimed over 16,500 deaths worldwide and accounted for more than 378,000 infections, with the epicenter shifting from China to Europe. Singling out Trump, she said: it’s dismaying, however, “to witness State off...
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Thursday 29 September 2022
The E.P.A. has approved nootkatone, which is found in cedars and grapefruit. It repels ticks, mosquitoes and other dangerous bugs for hours, but is safe enough to eat. (Source: NYT Health)
Thursday 29 September 2022
At my animal hospital in upstate New York, an epicenter of the U.S. tick epidemic, my dog Fawn lets out a whimper as the veterinarian injects her with her annual Lyme disease shot. I roll my eyes. She doesn’t know how good she has it. The injection means that if a tick bites her (and in rural New York, a tick always does), the creepy crawly will feast on dog blood that’s been supercharged with a Lyme bacteria-killing substance, and Lyme disease won’t be transmitted to Fawn. I wish I could be shot up with that superpower. Currently, there is no human vaccine for Lyme disease—even though more than two decades ago, people could get a safe and effective preventative shot similar to Fawn’s. Now, thanks to potent anti-vaccine pushback, all we can do is try to avoid ...
Thursday 29 September 2022
LYME disease is a debilitating bacterial infection and with lockdowns easing and more people venturing outside, knowing the potential risks and symptoms is extremely important. If you experience any of these six, lesser-known warning signs you may be at risk. (Source: Daily Express - Health)
Thursday 29 September 2022
Lyme disease experts are not surprised by CDC's failure to ensure quick diagnosis of COVID-19. It's failed for 25 years to fix a broken Lyme test. (Source: Forbes.com Healthcare News)
Thursday 29 September 2022
LYME disease is a bacterial infection which is transmitted by a tick bite. Feeling this sensation in your head could mean you're at risk. (Source: Daily Express - Health)
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Thursday 29 September 2022
Dr Paul Auwaerter highlights the major changes in this guideline, which was a collaboration of the IDSA, AAN, and ACR.Medscape Infectious Diseases (Source: Medscape Infectious Diseases Headlines)
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Thursday 29 September 2022
Her lethargy and joint pain suggested a tick-borne illness. Adding to the mystery, was a recent trip abroad a clue or a red herring? (Source: NYT Health)
Thursday 29 September 2022
(Columbia University) A new model based on 17 years of data can help predict the trajectory of where Lyme disease will spread. Identifying high-risk areas can lead to surveillance in counties and areas where infections are likely to emerge. It also allows authorities to alert physicians and the public, which can lead to early treatment, when it is most effective. (Source: EurekAlert! - Medicine and Health)
Thursday 29 September 2022
LYME disease is a bacterial infection that can be spread to humans by infected ticks, tiny spider-like creatures that dwell in woodland. Untreated Lyme disease can cause a host of debilitating health problems so it is vital to act on the early warning sign. (Source: Daily Express - Health)
Thursday 29 September 2022
Recent guidance from several specialty societies can answers many patients'questions and aid clinical decision-making regarding tick bites.Medscape Family Medicine (Source: Medscape Infectious Diseases Headlines)
Thursday 29 September 2022
Title: What Are the Symptoms of Lyme Disease by Stages?Category: Diseases and ConditionsCreated: 6/17/2020 12:00:00 AMLast Editorial Review: 6/17/2020 12:00:00 AM (Source: MedicineNet Arthritis General)
Thursday 29 September 2022
This cluster of Lyme disease cases in North Carolina indicates that the disease may be expanding further south.Morbidity & Mortality Weekly Report (Source: Medscape Today Headlines)
Thursday 29 September 2022
And if this was Bell ’s palsy, why wasn’t there improvement after a full year? (Source: NYT Health)
MedWorm Message: Have you tried our new medical search engine? More powerful than before. 100% free.
Thursday 29 September 2022
The blood-sucking critters are capable of thriving along the western coast, according to new research. Though experts don't exactly know how they're picking up the bacteria that causes the illness.(Image credit: James Gathany/AP) (Source: NPR Health and Science)
Thursday 29 September 2022
Lyme disease is a bacterial infection caused by the bite of an infected black-legged tick, commonly known as a deer tick. Preventing tick bites is the best defense against the disease. And now there is good news for those looking for an alternative insect repellant to fight off ticks, says Dr. Omar Abu Saleh, a Mayo Clinic [...] (Source: News from Mayo Clinic)
Thursday 29 September 2022
(Frontiers) A preclinical in vitro study shows that selected plant-based herbal medicines, especially Ghanaian quinine and Japanese knotweed, work better than antibiotics against the bacterium that causes Lyme disease. These findings represent an important step towards the development of treatments that might be better tolerated and more effective than the current standard of care. (Source: EurekAlert! - Infectious and Emerging Diseases)
Thursday 29 September 2022
Patients with Lyme neuroborreliosis, a late-stage manifestation of Lyme disease, may develop psychiatric illness, but new research suggests that when symptoms do develop, they tend to resolve within a year.Medscape Medical News (Source: Medscape Internal Medicine Headlines)
Thursday 29 September 2022
Lyme disease-carrying ticks usually found in woodlands and fields are spreading along California's beaches, carried by an unknown host. (Source: Los Angeles Times - Science)
Thursday 29 September 2022
(University of Arizona College of Engineering) In her Little Sensor Lab, University of Arizona professor Judith Su is working to sense single molecule amounts of 'anything worth sensing' -- including biomarkers for cancer, Alzheimer's disease, Lyme disease and even COVID-19. (Source: EurekAlert! - Medicine and Health)
Thursday 29 September 2022
LYME disease is a bacterial infection which could lead to severe physical and mental problems if not diagnosed at an early stage. Spotting the early warning signs will ensure prompt treatment and noticing this peculiar feeling in the head could mean you're at risk. (Source: Daily Express - Health)
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Thursday 29 September 2022
? (Source: eMedicineHealth.com)
MedWorm Message: Have you tried our new medical search engine? More powerful than before. 100% free.
Thursday 29 September 2022
From what to do when a patient presents with a tick, to which antibiotic to select for treatment.Medscape Family Medicine (Source: Medscape FamilyMedicine Headlines)
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Thursday 29 September 2022
Lyme disease is on the rise. How can you prevent it? What are the symptoms, and what should you do if you think you or your pet have it? (Source: FDA Center for Drug Evaluation and Research - What's New)
Thursday 29 September 2022
Engineers with the University of Cincinnati have created a tiny portable lab that plugs into your phone, connecting it automatically to a doctor's office through a custom app UC developed. The lab the size of a credit card can diagnose infectious diseases such as coronavirus, malaria, HIV or Lyme disease or countless other health conditions like depression and anxiety. (Source: eHealth News EU)
Thursday 29 September 2022
Credit: United Nations Office for Disaster Risk Reduction (UNDRR)By Lawrence SurendraBANGKOK, Thailand, Aug 24 2020 (IPS) The COVID 19 Pandemic continues relentlessly. Deaths approaching a million globally, 22 million infected and growing. Brazil, India, the US and Russia accounting for almost 50% of the total cases in the world. Medically the promise of a vaccine is given as signs of hope; what surprises awaits us when such a vaccine is available, would be another story. Economically, to address the uncertainty and the grim future ahead, the UN, some governments and even Joe Biden the US Presidential hopeful, are waving “Build Back better” as ways to achieve ‘a new normal’ out of the current pandemic. “Build Back Better” emerged out of the 3rd International Conference on Disa...
Thursday 29 September 2022
The disease is most often caused by the tiny parasites and transmitted to humans in warmer months by deer ticks — the same ones that spread Lyme disease. (Source: Washington Post: To Your Health)
Thursday 29 September 2022
LYME DISEASE is normally harmless, but if it is left untreated it can be deadly. How do you get Lyme disease? (Source: Daily Express - Health)
Thursday 29 September 2022
The recent discovery of Lyme-infected ticks at the location of an outdoor wilderness program in North Carolina highlights the importance of vectorborne disease prevention. (Source: CDC Morbidity and Mortality Weekly Report)
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Thursday 29 September 2022
Platinum Seal allows donors to focus on progress and results for top Lyme disease organization(PRWeb August 10, 2020)Read the full story at https://www.prweb.com/releases/global_lyme_alliance_reaches_guidestars_highest_seal_of_transparency/prweb17313403.htm (Source: PRWeb: Medical Pharmaceuticals)
Thursday 29 September 2022
Don Murry Grubbs, from White House, Tennessee was diagnosed with two tick-borne illnesses - Lyme disease and Rocky Mountain Spotted Fever - after being bitten by two different ticks. (Source: the Mail online | Health)
Thursday 29 September 2022
EXCLUSIVE: Kelly Brooks, 27, of Hampshire, suffers from chronic Lyme disease - a tick-borne condition that has severe symptoms including agonising joint pain, fatigue and headaches. (Source: the Mail online | Health)
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Thursday 29 September 2022
The pensioner, from Castelo Branco, Portugal, went to hospital with excruciating pains in his chest and extremely low blood pressure. Justin Bieber announced he had the illness last week. (Source: the Mail online | Health)
Thursday 29 September 2022
SATURDAY, Aug. 1, 2020 -- Summer means higher odds of getting Lyme disease, so know how to avoid it, health experts say. Lyme disease is caused by a bacterium carried by some ticks and, if left untreated, can cause severe health problems. Ticks can... (Source: Drugs.com - Daily MedNews)
Thursday 29 September 2022
The former “Bachelorette” winner has Lyme disease that was triggered by high levels of mold in his body, he shared on wife Trista... (Source: Reuters: Health)
Thursday 29 September 2022
With no vaccine against Lyme right now, the author and his colleagues are working to create seasonal protection. (Source: Washington Post: To Your Health)
Thursday 29 September 2022
For now, the only prevention lies in avoiding tick contact but one company, Valneva, is working fervently to develop what they believe will be the world ’s first vaccine against Lyme’s disease. (Source: Forbes.com Healthcare News)
Thursday 29 September 2022
by Sarah Elizabeth Adler, AARP, Updated July 14, 2020 | ... En espa ñol | Ticks: They're the tiny pests that stop outdoor fun in its tracks — and experts say they stay active well into fall, making ... (Source: AARP.org News)
Thursday 29 September 2022
(University of Maryland) The University of Maryland (UMD) received funding from the Steven& Alexandra Cohen Foundation to develop novel therapeutic strategies to stop infection from Lyme disease pathogens before it begins. Unlike traditional antibiotics that attack the pathogen directly and put it on the defensive, UMD is exploring antimicrobials that would interfere with the pathogen on a biomolecular level to inhibit it from causing an infection in the first place. (Source: EurekAlert! - Infectious and Emerging Diseases)
Thursday 29 September 2022
(NEW YORK) — WNBA MVP Elena Delle Donne was shocked and hurt when her request to be medically excused for the season was denied by an independent medical panel. Having battled Lyme disease for more than a decade and now taking 64 pills a day, she thought she was definitely going to be considered high-risk to get severe illness if she contracted the coronavirus. The panel of independent doctors the league and union agreed upon to make that decision thought otherwise, ruling Monday that she was not “high risk, and should be permitted to play in the bubble.” The disease is not included on the Centers for Disease Control and Prevention’s list of underlying conditions that could put someone at an increased risk for severe illness from COVID-19. The Washington Mystics st...
Thursday 29 September 2022
Singer Justin Bieber says he has Lyme disease, revealing his condition Wednesday in an Instagram post addressing comments people have made about his appearance in recent months. (Source: WebMD Health)
Thursday 29 September 2022
(CNN) — After more than three months of shutdowns, mandatory quarantines, self-imposed exile from society and working from home, nature-lovers looking for a well-earned breath of fresh air could face a possible collision course between coronavirus and tick-borne illnesses this summer. A “perfect storm,” warns Eva Sapi, a University of New Haven biology professor and group director for the Lyme Disease Research Group. Noting the mild winter on the East Coast, Sapi says, “We do have a bad year for the ticks.” Hikers, campers and anyone else eager for an escape could “just explode into the outdoors. And there may not be the same thoughtful approach” to preventing exposure, explains Dr. Sorana Segal-Maurer, director of the Dr. James J. Rahal, Jr. Divi...
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Thursday 29 September 2022
LYME DISEASE is an infection spread by ticks and is potentially life-threatening. How common is lyme disease in the UK? (Source: Daily Express - Health)
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Thursday 29 September 2022
Title: What Happens if You Go Untreated for Lyme Disease?Category: Diseases and ConditionsCreated: 6/17/2020 12:00:00 AMLast Editorial Review: 6/29/2020 12:00:00 AM (Source: MedicineNet Arthritis General)
Thursday 29 September 2022
(NEW YORK) — Justin Bieber says that he has been battling Lyme disease. In an Instagram post on Wednesday, the pop star wrote that “it’s been a rough couple years but (I’m) getting the right treatment that will help treat this so far incurable disease and I will be back and better than ever.” Lyme disease is transmitted by Ixodes ticks, also known as deer ticks. Lyme can cause flu-like conditions, neurological problems, joint paint and other symptoms. “While a lot of people kept saying justin Bieber looks like (expletive), on meth etc. they failed to realize I’ve been recently diagnosed with Lyme disease, not only that but had a serious case of chronic mono which affected my, skin, brain function, energy, and overall health,” Bieber wrote. Th...
Thursday 29 September 2022
Discussion Bradycardia is a heart rate below what the lowest value that is normal for age. Infants and children have higher heart rates that slowly decrease with age to adult levels. It is usually noted as an incidental finding because of increased vagal tone. Reasons for cardiology referral include associated heart murmur, syncope especially if associated with exercise or unusual triggers, other signs such as chest pain or palpitations, family history of sudden cardiac death, congenital heart disease or familial heart disease, bradycardic medication use, or unusual symptoms associated with the concern. Severe bradycardia that causes poor cardiac output is a medical emergency. Fortunately most children have mild bradycardia which may have no symptoms or can manifest as dizziness, syncope, ...
Thursday 29 September 2022
This winter was one of the warmest on record, and lingering summer heat could add weeks of outdoor activity to animals that carry ticks, which thrive in hot, humid conditions. (Source: WebMD Health)
Thursday 29 September 2022
WEDNESDAY, June 17, 2020 -- Tick monitoring and control is lacking in much of the United States despite a steady increase in tick-borne illnesses, such as Lyme disease, a new study finds. In the United States, tick-borne illnesses more than doubled... (Source: Drugs.com - Daily MedNews)
Thursday 29 September 2022
Lyme disease is the most common illness spread by ticks in North America and Europe. View Lyme disease symptoms, treatments and prevention tips. (Source: CNN.com - Health)
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Thursday 29 September 2022
(Entomological Society of America) While the prevalence of Lyme disease and other illnesses spread by ticks has steadily increased in the United States over the past 20 years, a new study of the state of American tick surveillance and control reveals an inconsistent and often under-supported patchwork of programs across the country. (Source: EurekAlert! - Infectious and Emerging Diseases)
Thursday 29 September 2022
For the first time, Lyme disease-carrying ticks -- typically associated with woodlands in New England and other forested regions of the US -- have been found in abundance near beaches in Northern California, new research shows.WebMD Health News (Source: Medscape Infectious Diseases Headlines)
Thursday 29 September 2022
CORONAVIRUS symptoms have been shown to range from a dry cough to conjunctivitis, but some of these symptoms are also linked to other conditions such as Lyme disease. How can you tell the difference between COVID-19 and Lyme disease? (Source: Daily Express - Health)
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Thursday 29 September 2022
Thursday 29 September 2022
SUNDAY, July 25, 2021 -- When you're heading outdoors this summer, keep an eye out for ticks during and after your outing, health experts say. These common parasites can transmit Lyme disease, a potentially serious illness. Lyme disease is... (Source: Drugs.com - Daily MedNews)
Thursday 29 September 2022
In Northern California, the proportion of ticks infected with the bacterium Borrelia burgdorferi was the same in shrubland along beaches as in woodland habitats. (Source: The Scientist)
Thursday 29 September 2022
LYME DISEASE is a tick-borne infectious disease. Initial symptoms are usually mild, but if left untreated, more serious symptoms may reveal themselves. Have you spotted these serious signs? (Source: Daily Express - Health)
Thursday 29 September 2022
Mother ’s fundraising campaign in Lyme Regis has been backed by likes of David AttenboroughEvie Swire was nine years old when she first heard the story of a woman who had lived near her home in Dorset and, in her own way, changed the world.Mary Anning was born into a humble family in Lyme Regis in 1799 and grew up hunting for fossils in the area ’s cliffs to supplement their meagre income. When she was 12, she and her brother discovered one of the first ichthyosaurus skeletons, and she would go on to make many other pioneering finds and become immensely knowledgeable in the emerging field of palaeontology.Continue reading... (Source: Guardian Unlimited Science)
Thursday 29 September 2022
An Ontario health advocacy group is calling for more action to protect children from the harmful impacts of climate change. The group says cases of asthma, heat stroke and Lyme disease could all be on the rise in the coming decades. (Source: CBC | Health)
Thursday 29 September 2022
"I don’t think we were expecting to find many ticks, but we did, and we found heaps of ticks in big numbers. And they’re infected with diseases," the study's lead author said. (Source: Washington Post: To Your Health)
Thursday 29 September 2022
Several groups have differing guidelines for diagnosing and treating Lyme. Too much is in dispute, since our knowledge is so limited. (Source: Forbes.com Healthcare News)
Thursday 29 September 2022
NEW YORK (CBS) – The United States has seen a big rise in the number of Lyme disease cases. A new study finds that the number of Americans diagnosed with the illness more than doubled over the past decade. Researchers at FAIR looked at private health insurance claims from 2007 to 2018. They found the biggest increase was in urban areas where claims for Lyme disease increased by more than 120%. Read The Report (PDF) “Lyme disease is the nation’s predominant tick-borne disease, and it is growing,” FAIR said in its report. Massachusetts was among the Top 10 states with the highest percentages of insurance claims for Lyme. The infection is spread through tick bites and can affect joints, the nervous system and heart if it goes untreated. (Source: WBZ-TV - Breaking News, Weather and Spo...
Thursday 29 September 2022
UK cohort study (n=8.4 million) found that the number of cases of Lyme disease has increased rapidly since 2001, resulting in an incidence of 12.1 per 100,000 per year in 2012. Authors state that this should lead to increased awareness and the need for preventative measures. (Source: Current Awareness Service for Health (CASH))
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Thursday 29 September 2022
Promising data show that a viral gene in the Lyme disease-causing bacteria can distinguish between early and late infection.Medscape Medical News (Source: Medscape Rheumatology Headlines)
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Thursday 29 September 2022
Cases of a nasty infection passed on through tick bites may be much higher in the UK than previously thought, according to new research. (Source: Nursing Times)
Thursday 29 September 2022
(CNN/CBS) — The climate crisis is making us more vulnerable to ticks in an unprecedented and growing threat to public health, according to a new report. Bacterial and protozoan tick-borne diseases doubled in the United States between 2004 and 2016, the report notes, and in 2017, more than 90% of the 60,000 vector-borne diseases in the United States were linked to these particular bloodsucking bugs. The warmer temperatures brought by the climate crisis, in addition to ecological changes and reforestation, have extended the bugs’ range into regions that had not seen certain types of ticks for many decades, if ever. And the report published in the New England Journal of Medicine Tuesday warns that we should be “bracing for the worst.” The lone star tick, a tick disting...
Thursday 29 September 2022
Researchers say tick-borne disease ‘is everywhere’ with 8,000 diagnoses likely in 2019Cases of Lyme disease in the UK may be three times higher than previous estimates, according to new research.After analysing the anonymous medical records of 8.4 million people from across the UK, scientists forecast that the total number of Lyme disease diagnoses in the UK could top 8,000 in 2019, compared withpreviousestimates of between 2,000 and 3,000 annual diagnoses.Continue reading... (Source: Guardian Unlimited Science)
Thursday 29 September 2022
(Columbia University Irving Medical Center) With a $16 million gift from the Steven& Alexandra Cohen Foundation, Columbia will open a center for Lyme and other tick-borne diseases this summer, offering patients specialized care and expanding research at a national level. (Source: EurekAlert! - Infectious and Emerging Diseases)
Thursday 29 September 2022
WEDNESDAY, July 31, 2019 -- The incidence of Lyme disease (LD) increased from 2001 to 2012 in the United Kingdom, with an estimated incidence rate of 12.1 per 100,000 individuals per year, according to a study published online July 30 in BMJ... (Source: Drugs.com - Pharma News)
Thursday 29 September 2022
I’m always so proud of what our union stands for and what we can achieve when we stand together. But sometimes there are days when that’s particularly true – and earlier this week I had one of those days. It started early on a picket line at Whiston Hospital. The strikers – employed by Compass – have a simple demand, to get the same pay and conditions as those they work alongside in our NHS. Their energy, their passion and their unwillingness to give in are truly inspiring. These are the people who keep our NHS – our nation’s greatest achievement – running each day. They clean, they cook and they make sure patients are where they’re meant to be. They embody the incredible values of the NHS and our union, and it’s time that Compass (a company whic...
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Thursday 29 September 2022
The modified approach for detecting exposure to Borrelia burgdorferi uses two enzyme immunoassays, with no need for Western blot.FDA Approvals (Source: Medscape Emergency Medicine Headlines)
Thursday 29 September 2022
(The Translational Genomics Research Institute) The findings of a recent analysis conducted by the Translational Genomics Research Institute (TGen), an affiliate of City of Hope, suggest that ecosystems suitable for harboring ticks that carry debilitating Lyme disease could be more widespread than previously thought in California, Oregon and Washington. Bolstering the research were the efforts of an army of " citizen scientists " who collected and submitted 18,881 ticks over nearly three years. (Source: EurekAlert! - Infectious and Emerging Diseases)
Thursday 29 September 2022
Research has found strains of Klebsiella pneumoniae resistant to the carbapenems spreading through hospitals Related items fromOnMedica GPs given help to spot Lyme disease Single-dose malaria drug eliminates parasite from liver Antibiotic research programme launched Measles cases triple in Europe but immunisation rates grow Chief medical officer launches push for flu jab drive (Source: OnMedica Latest News)
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Thursday 29 September 2022
Chronic Lyme disease occurs when a person who has already received treatment for Lyme disease continues to have symptoms in the long term. Learn more about this condition here. (Source: Health News from Medical News Today)
Thursday 29 September 2022
Discussion Dengue is an important arboviral infection that affects about 40% of the world population. It is found mainly in topical and subtropical areas of the world mainly in developing countries but it range is spreading including the United States. A review of common arboviruses can be found here. It is a flaviavirus with 4 distinct serotypes named DENV-1 through DENV-4 and is spread by A. aegypti a day biting mosquito. Infection with one serotype confers immunity to that serotype but not the others. It does offer some protection for cross-infection but this only lasts a few months. Incubation period is 3-14 days with an average of 7 after exposure. A primary infection is usually benign. A second infection with another serotype or multiple infections with different serotypes can caus...
Thursday 29 September 2022
(TellMed Strategies) Bay Area Lyme Foundation, a leading sponsor of Lyme disease research in the U.S., today announced the publication of new data finding that five herbal medicines had potent activity compared to commonly-used antibiotics in test tubes against Babesia duncani, a malaria-like parasite found on the West Coast of the U.S. that causes the disease babesiosis. (Source: EurekAlert! - Infectious and Emerging Diseases)
Thursday 29 September 2022
Carly Ellis, from Gloucester, was diagnosed with the infection in 2011, with doctors saying a two-week course of antibiotics would 'clear' her. (Source: the Mail online | Health)
Thursday 29 September 2022
A novel PET imaging technique has uncovered high levels of ischemia in patients...Read more on AuntMinnie.comRelated Reading: PET/MRI sheds light on cerebral vascular risk factors Flortaucipir-PET shows tau accumulation after one TBI PET, MRI show physical activity aids brain health Carbon-11 PET detects brain inflammation after Lyme disease SNMMI: Cerebrovascular risk tied to Alzheimer's disease (Source: AuntMinnie.com Headlines)
Thursday 29 September 2022
Health officials have confirmed that an individual in Maine is sick with Powassan virus disease, marking the first time since 2017 that a person in the state has come down with the rare and serious tick-borne illness. The Maine Center for Disease Control and Prevention announced Wednesday that a southern Maine resident was hospitalized for Powassan encephalitis—brain inflammation associated with the virus—after showing symptoms in late June. The announcement did not specify the individual’s current condition, but health officils doctors to stay vigilant about the potential spread of Powassan throughout the summer and early fall. Here’s what to know about the tick-borne Powassan virus disease. What is Powassan virus disease? Like Lyme disease, Powassan is spread by ...
Thursday 29 September 2022
Child abuse is one of the most common causes for child fatality in the United States. Inaccurate reporting of child abuse combined with scarcity of resources for child abuse evaluations can lead to unintended consequences for children and their families. T... (Source: SafetyLit)
Thursday 29 September 2022
The ideal test for Lyme disease needs to be direct and highly sensitive in specific areas of detection. A new review highlights the 5 key criteria. (Source: ConsultantLive)
Thursday 29 September 2022
First ever cases in Britain, says Public Health England Related items fromOnMedica Vaccine linked to earlier onset of seizures in Dravet syndrome Scans show severe brain damage in Zika-affected babies Lyme disease may be three times more common in UK than previously thought Single-dose malaria drug eliminates parasite from liver Common anti-parasitic could be new tool for malaria control (Source: OnMedica Latest News)
Thursday 29 September 2022
Ottawa Public Health has stopped collecting ticks after it found a high number of the arachnids within the city carry Lyme disease. (Source: CBC | Health)
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Thursday 29 September 2022
Special 50p coins will feature some of the Jurassic creatures discovered by 19th-century palaeontologistOne of the most terrifying Jurassic sea creatures is to appear on commemorative 50p coins to celebrate the work of thepioneering fossil hunter Mary Anning.The temnodontosaurus coins will shine a light on the 19th-century palaeontologist, who made a series of discoveries near her home in Lyme Regis, Dorset.Continue reading... (Source: Guardian Unlimited Science)
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Thursday 29 September 2022
Clare Haworth, from North Lanarkshire, first became ill six years ago but doesn't remember ever being bitten by a tick, which is how people catch Lyme disease. (Source: the Mail online | Health)
Thursday 29 September 2022
Two newly reported cases of fatal Lyme carditis serve as a reminder of the importance of prompt identification and treatment of this potentially life-threatening infection.Reuters Health Information (Source: Medscape Medical News Headlines)
Thursday 29 September 2022
This quality standard covers diagnosing and managing Lyme disease in people of all ages. It also includes raising public awareness about prevention. It describes high-quality care in priority areas for improvement. It was published in July 2019. (Source: Current Awareness Service for Health (CASH))
Thursday 29 September 2022
Title: What Is Lyme Disease in Humans?Category: Diseases and ConditionsCreated: 12/31/1997 12:00:00 AMLast Editorial Review: 2/12/2021 12:00:00 AM (Source: MedicineNet Arthritis General)
Thursday 29 September 2022
Lab tests not needed if rash is present, says NICE Related items fromOnMedica TB could be cured by four months ’ treatment in many patients Antibiotics courses often longer than guidelines Doctors call for StrepB screening in late pregnancy JCVI recommends universal HPV vaccination New ‘treadmill test’ can predict mortality (Source: OnMedica Latest News)
Thursday 29 September 2022
LYME disease is a bacterial infection spread to humans by infected ticks. Ticks are tiny spider-like creatures found in woodland and heath areas. They feed on the blood of birds, mammals and humans. Feeling this sensation in your head could mean you have Lyme disease. (Source: Daily Express - Health)
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Thursday 29 September 2022
Find out how park connectivity and landscape composition may contribute to Lyme disease risk in urban areas.Emerging Infectious Diseases (Source: Medscape Today Headlines)
Thursday 29 September 2022
(PLOS) A new analysis suggests that north-south differences in ticks' host choice, density, and host-seeking behaviors may explain why Lyme disease is more prevalent in the northeastern U.S. than in the southeast. Howard Ginsberg of the U.S. Geological Survey's Patuxent Wildlife Research Center and colleagues present these findings in an article publishing January 28th in the open-access journalPLOS Biology. (Source: EurekAlert! - Infectious and Emerging Diseases)
Thursday 29 September 2022
This week's NYTimes did a disservice to readers by minimizing the severity of Lyme disease. Here's why. (Source: Forbes.com Healthcare News)
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Thursday 29 September 2022
DR MARTIN SCURR: Pat Toovey from Norfolk found a tick on his wife's back two years ago and she is constantly in pain and struggles to get out of bed. He fears she has Lyme disease. (Source: the Mail online | Health)
Thursday 29 September 2022
Horror stories about lingering Lyme disease proliferate, but the illness is easily treated. (Source: NYT Health)
Thursday 29 September 2022
(Cary Institute of Ecosystem Studies) A new study published in the journalGlobal Ecology and Biogeography used machine learning to identify bird species with the potential to transmit the Lyme disease bacterium (Borrelia burgdorferi) to feeding ticks. The team developed a model that identified birds known to spread Lyme disease with 80% accuracy and flagged 21 new species that should be prioritized for surveillance. (Source: EurekAlert! - Medicine and Health)
Thursday 29 September 2022
New Yale research offers insight into why some Lyme disease patients continue to suffer from debilitating arthritis even after antibiotic treatment. (Source: Yale Science and Health News)
Thursday 29 September 2022
With an increase of nearly 10,000 cases of tickborne disease from 2016 to 2017 -- mostly lyme disease -- the National Institutes of Health announced a five-year plan to expand research and reduce infections. (Source: Health News - UPI.com)
Thursday 29 September 2022
Lyme disease can cause long-term joint inflammation that lasts long after the body has cleared the infection. A new study uncovers how this might happen. (Source: Health News from Medical News Today)
Thursday 29 September 2022
Crowdfunder led by schoolgirl raises £70,000 for sculpture of pioneering palaeontologist in Lyme Regis, DorsetA statue toMary Anning, a fossil hunter and palaeontologist once “lost to history” but now considered a significant female force in science, is finally to be erected after a crowdfunding campaign by a teenage girl.Evie Swire, 13, was nine years old when she first heard of Anning, who was born into a humble family in 1799 near Evie ’s Lyme Regis home in Dorset. The schoolgirl was outraged to discover there was no statue.Continue reading... (Source: Guardian Unlimited Science)
Thursday 29 September 2022
Morven-May MacCallum speaks out as GPs are urged to be vigilant about the infection spread by ticks. (Source: BBC News | Health | UK Edition)
Thursday 29 September 2022
LYME disease is a bacterial infection which is spread to humans via tick bites. The most notable symptom is the rash that develops, but not all symptoms associated with the condition necessarily point to Lyme disease. (Source: Daily Express - Health)
Thursday 29 September 2022
The tick that carries Lyme can also transmit the rare but serious powassan virus believed to have killed one man and sickened another in New Jersey (Source: Health News: CBSNews.com)
Thursday 29 September 2022
Roughly 500,000 people across the United States are diagnosed with Lyme disease each year, according to new estimates released Wednesday by the CDC, but researchers raise concern that some people may be misdiagnosed. (Source: Health News - UPI.com)
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Thursday 29 September 2022
There are new concerns about previously-rare types of tick-borne diseases being seen more frequently in the United States. The blacklegged tick not only spreads Lyme disease, it can also transmit a serious virus that may have killed one man and made another sick in New Jersey. In Kentucky, a two-year-old boy is reportedly recovering from another tick-borne disease, Rocky Mountain spotted fever. Dr. David Agus joins "CBS This Morning" from Los Angeles to discuss how to protect yourself from ticks, how to remove them and the consequences of some tick-borne diseases. (Source: Health News: CBSNews.com)
Thursday 29 September 2022
Three medical stories that we didn't cover, explained.Medscape (Source: Medscape Allergy Headlines)
Thursday 29 September 2022
-- Lyme disease is caused by a bacterium that may be acquired from the bite of an infected tick. Left untreated, the infection can spread throughout the body and cause serious complications, says the U.S. Centers for Disease Control and... (Source: Drugs.com - Daily MedNews)
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Thursday 29 September 2022
A new model helps identify areas with high populations of the ticks that carry Lyme disease, a study published Tuesday by the Proceedings of the Royal Society B found. (Source: Health News - UPI.com)
Thursday 29 September 2022
Discussion Facial nerve palsy has been known for centuries, but in 1821 unilateral facial nerve paralysis was described by Sir Charles Bell. Bell’s palsy (BP) is a unilateral, acute facial paralysis that is clinically diagnosed after other etiologies have been excluded by appropriate history, physical examination and/or laboratory testing or imaging. Symptoms include abnormal movement of facial nerve. It can be associated with changes in facial sensation, hearing, taste or excessive tearing. The right and left sides are equally affected but bilateral BP is rare (0.3%). Paralysis can be complete or incomplete at presentation. All ages can be affected but there are increased risks in the 15-45 year age group and those with diabetes, immunodeficiency or are pregnant. Etiology is specif...
Thursday 29 September 2022
Recently, the FDA cleared several Lyme disease serologic assays with new indications for use, allowing for an EIA rather than western immunoblot assay as a confirmatory test.Morbidity & Mortality Weekly Report (Source: Medscape Today Headlines)
MedWorm Message: Have you tried our new medical search engine? More powerful than before. 100% free.
Thursday 29 September 2022
UK researchers discover new compound which kills antibiotic-resistant superbugs Related items fromOnMedica GPs given help to spot Lyme disease Single-dose malaria drug eliminates parasite from liver TB could be cured by four months ’ treatment in many patients Antibiotics courses often longer than guidelines 'Keep Antibiotics Working' campaign resurfaces (Source: OnMedica Latest News)
Thursday 29 September 2022
The meeting will bring together researchers and scientists from across the SUNY system. (Source: SUNY Upstate Medical)
Thursday 29 September 2022
Tick bites: First aid Most tick bites are painless and cause only minor symptoms, such as redness, swelling or a sore on the skin. But some ticks transmit bacteria that cause illnesses, including Lyme disease and Rocky Mountain spotted fever. Learn the correct way to remove and handle a tick, and when you need to [...] (Source: News from Mayo Clinic)
Thursday 29 September 2022
John St Julien, now 34, moved to east Africa in 2014 to launch a charity helping local children be educated. He soon started to feel run down but dismissed it as the pressure of his job. (Source: the Mail online | Health)
Thursday 29 September 2022
Infected ticks were mostly found in forested parks with vegetation around the edges and connected to each other. (Source: WebMD Health)
Thursday 29 September 2022
(University of Illinois at Urbana-Champaign, News Bureau) By drawing from decades of studies, scientists created a timeline marking the arrival of black-legged ticks, also known as deer ticks, in hundreds of counties across 10 Midwestern states. They used these data - along with an analysis of county-level landscape features associated with the spread of ticks - to build a model that can predict where ticks are likely to appear in future years. (Source: EurekAlert! - Infectious and Emerging Diseases)
Thursday 29 September 2022
WEDNESDAY, May 15, 2019 -- As deer populations have exploded across America, moving from forests to suburbs to urban parks, they have brought the threat of Lyme disease to millions of city dwellers, a new study finds. In fact, the deer tick that... (Source: Drugs.com - Daily MedNews)
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Thursday 29 September 2022
LYME disease may have an innocent sounding name, but it ’s a nasty condition transmitted by ticks which, left untreated, can lead to severe health problems. Here are three parts of body you should always check after visiting grassy and woodland areas, as well as other symptoms you should look out for. (Source: Daily Express - Health)
Thursday 29 September 2022
Dr Tillmann Jacobi considers red flag symptoms in erythema and details three of the most common causes; Lyme disease, erythema infectiosum and erythema multiforme. (Source: GP Online Education)
Thursday 29 September 2022
FRIDAY, Dec. 11, 2020 -- In new evidence-based clinical practice guidelines, published online Nov. 30 in Clinical Infectious Diseases, recommendations are presented for the prevention, diagnosis, and treatment of Lyme disease. The guidelines were... (Source: Drugs.com - Pharma News)
Thursday 29 September 2022
Might some patients with early Lyme disease show evidence of co-infection with other tickborne pathogens?Emerging Infectious Diseases (Source: Medscape Today Headlines)
Thursday 29 September 2022
FRIDAY, Aug. 16, 2019 -- The Infectious Diseases Society of America, the American Academy of Neurology, and the American College of Rheumatology have released a draft of their joint clinical practice guidelines for the management of Lyme... (Source: Drugs.com - Pharma News)
Thursday 29 September 2022
TUESDAY, April 23, 2019 -- With growing concern about mosquito-borne viruses such as Zika, it's easy to let down your guard when it comes to ticks. But Lyme disease is still a danger, especially in the Northeast and upper Midwest. In fact, it has... (Source: Drugs.com - Daily MedNews)
Thursday 29 September 2022
(University of California - San Francisco) Ticks live dangerous lives, spending most of their time questing for a host across wildly different habitats and seasons. Once they encounter a reptile, bird, or a mammal like us, they become intimately connected with it -- and all of its bacteria and viruses -- for days on end. Though ticks are notorious for transmitting pathogens such as the Lyme disease bacterium, how does their immune system keep them safe from contracting pathogens themselves? (Source: EurekAlert! - Infectious and Emerging Diseases)
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Thursday 29 September 2022
Lyme disease is a tickborne zoonosis for which serologic testing is the principal means of laboratory diagnosis. (Source: CDC Morbidity and Mortality Weekly Report)
Thursday 29 September 2022
As I struggle with chronic pain, cozy for me is less hygge and more my ex-boyfriend ’ s mother, nurses with juice and weird, sandy doughnuts. (Source: NYT Health)
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Thursday 29 September 2022
New clinical practice guidelines on Lyme disease place a strong emphasis on antibody testing to assess for rheumatologic and neurologic syndromes.Medscape Medical News (Source: Medscape Infectious Diseases Headlines)
Thursday 29 September 2022
EAST HADDAM, Conn. (WTNH) - A meeting is set to take place on Saturday to discuss a growing concern in East Haddam where a number of EMS volunteers resigned from their positions, putting a bit of strain on neighboring communities. Ten people have left East Haddam Ambulance since the beginning of the year. It's a non-profit organization that gets about 800 calls a year. Since they're down so many people, about 20 percent of the emergency calls in East Haddam are being taken care of by other emergency crews in neighboring towns like Haddam, Lyme, East Hampton, and Colchester. (Source: JEMS: Journal of Emergency Medical Services News)
Thursday 29 September 2022
Scientists from the National Institute for Health Research in London analysed 2,361 patients who were admitted to hospital with the bacterial infection between 1998 and 2015. (Source: the Mail online | Health)
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Thursday 29 September 2022
Laura Macleod, 31, tested positive for Lyme disease in 2016 but the standard treatment did nothing to alleviate her symptoms. Now, wants to travel to Germany for dangerous full body heating. (Source: the Mail online | Health)
Thursday 29 September 2022
OBJECTIVE: Lyme borreliosis is a tick-borne infectious disease that may confer an increased risk of mental disorders, but previous studies have been hampered by methodological limitations, including small sample sizes. The authors used a nationwide retrosp... (Source: SafetyLit)
Thursday 29 September 2022
Eye on Innovation features exciting advances taking place at Mayo Clinic Laboratories. This monthly series shines a spotlight on recently developed tests and highlights how Mayo Clinic translates ideas and discoveries into testing resources that improve diagnosis and care for patients across the globe. ______________________________________________ It ’s long been known that Lyme disease is caused by bacteria transmitted through the bite of an infected black-legged tick (otherwise known as the deer tick). The understanding for many years was… (Source: News from Mayo Clinic)
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Thursday 29 September 2022
This case describes an unusual dermatologic presentation of Lyme disease, borrelial lymphocytoma, which is rare in the US but more common in Europe.Journal of Medical Case Reports (Source: Medscape Today Headlines)
Thursday 29 September 2022
The clinical manifestations of this tickborne disease can differ according to the species causing the infection.Emerging Infectious Diseases (Source: Medscape Today Headlines)
Thursday 29 September 2022
Headlines on COVID-19 and monkeypox underscore the importance of understanding infectious diseases and how they're transmitted. Scientists are studying these diseases, such as hand, foot and mouth disease and Lyme disease, to gain insights into how … (Source: NSF News)
Thursday 29 September 2022
TUESDAY, Aug. 17, 2021 -- Patients hospitalized with Lyme disease have a higher rate of mental disorders and attempted suicide after infection, according to a study published online July 28 in The American Journal of Psychiatry. Brian A. Fallon,... (Source: Drugs.com - Pharma News)
Thursday 29 September 2022
To what extent did the invasion of the blacklegged tick contribute to the spread of Lyme disease?Emerging Infectious Diseases (Source: Medscape Today Headlines)
Thursday 29 September 2022
(Source: The Doctors Lounge - Psychiatry)
Thursday 29 September 2022
(Johns Hopkins University Bloomberg School of Public Health) A new study from researchers at the Johns Hopkins Bloomberg School of Public Health found that a slow-growing variant form of Lyme bacteria caused severe symptoms in a mouse model. The slow-growing variant form of Lyme bacteria, according to the researchers, may account for the persistent symptoms seen in ten to twenty percent of Lyme patients that are not cured by the current Lyme antibiotic treatment. (Source: EurekAlert! - Medicine and Health)
Thursday 29 September 2022
Lyme Disease May Up Risk for Mental Illness, Suicidal Behavior (Source: eMedicineHealth.com)
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Thursday 29 September 2022
Researchers from across Europe, including the University of East London, mapped reports of the Lyme disease-causing Borrelia burgdorferi bacteria in ticks from 2010 to 2017. (Source: the Mail online | Health)
Thursday 29 September 2022
Increased inflammation, immune activation, and psychological factors may help explain the association of Lyme disease with higher rates of psychiatric disorders and suicidal behavior, researchers say.Medscape Medical News (Source: Medscape Medical News Headlines)
Thursday 29 September 2022
Clive Stafford Smithsays Sats are irrelevant to his son ’s life andMary Bousteddefends Labour ’s proposed assessment reforms, whileAnn MooreandRichard Wetherellhighlight the negative effects of testsAmanda Spielman may be warning the wrong people about exam anxiety, certainly as far as younger kids are concerned (Ofsted chief says teachers can cause ‘subliminal’ exam anxiety, May 14). My 10-year-old is not worried because I have told him Sats are irrelevant to his life. His secondary school will determine how best he will fit in, based on its own testing, when he gets there in September. I did ask him to do his best in sympathy with the people who are sweating it out this week: his excellent teachers, whose lives – and the rating of the school – depend on how he does at rote no...
Thursday 29 September 2022
DR ELLIE CANNON: There are between 2,000 and 3,000 cases of Lyme disease every year in England and Wales - with areas such as the New Forest and Scottish Highlands the highest risk. (Source: the Mail online | Health)
Thursday 29 September 2022
LYME disease is a relatively unknown condition with an estimated 2,000 to 3,000 new cases each year in England and Wales. For an unknown disease however, anyone can develop the condition as its caught by a tick. This major symptom could mean you might have Lyme disease. Do you have it? (Source: Daily Express - Health)
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Thursday 29 September 2022
When health experts talk about the remarkable efficacy of COVID-19 vaccines, they typically point to their ability to prevent severe disease and death. Fully vaccinated people can still get “breakthrough” infections from the virus that causes COVID-19—but compared to an unvaccinated person, they’re more than 10 times less likely to be hospitalized or die from their illness, according to U.S. Centers for Disease Control and Prevention (CDC) research. Officials often point to these impressive figures as evidence that we can tame COVID-19 into a mostly mild illness that behaves like a routine cold or flu, and thus with which we can coexist. After all, the vaccines were not designed to quash viral spread entirely; they were designed to defang the virus by preventing its...
Thursday 29 September 2022
Christine Jennings, 57, of Leicester, was bitten by an infected tick 25 years ago and her life has never been the same. The disease affected every part of her health leaving her barely holding on to life. (Source: the Mail online | Health)
Thursday 29 September 2022
FINDINGSA UCLA study suggests that many physicians may not have the knowledge or training to properly recognize how Lyme disease appears on the skin of Black patients. The disease, caused by the tick-borne Borrelia bacterium, generally begins with a bull ’s-eye–shaped rash on the skin, along with fever, headache, chills and muscle pain; if not diagnosed promptly and treated with antibiotics, it can lead to more severe and long-lasting symptoms.UCLA ’s Dr. Dan Ly found that approximately 1 in 3 Black patients who were newly diagnosed with Lyme disease already had related neurological complications such as meningitis, neuropathy and cranial neuritis — an indication that the disease may not have been properly diagnosed in its earlier stages. Less than 1 in 10 newly diagnosed white pat...
Thursday 29 September 2022
Being outdoors during the warm weather season carries with it the risk of bites of all kinds – insects, animals, ticks and others. Here is some helpful advice for treating bites and itching. Check the symptoms. Most insect bites and stings are mild, causing minor symptoms like itching, redness, stinging or a small degree of swelling around the bite. In some rare cases, stings from hornets, bees, wasps, scorpions or fire ants may lead to more serious reactions, including mosquito-borne West Nile virus. The Mayo Clinic advises moving away from the area where you were stung or bitten to prevent further injury. Then, try to remove the stinger if needed, and wash the wound with soap and water. For tick bites, remove the tick immediately. The Cleveland Clinic says the longer a tick...
Thursday 29 September 2022
An exciting new finding by. Dr. Kim Lewis of Northeastern University gives hope that Lyme disease can be potentially treated without harming the microbiome.(PRWeb October 07, 2021)Read the full story at https://www.prweb.com/releases/global_lyme_alliance_congratulates_dr_kim_lewis_on_groundbreaking_publication_a_selective_antibiotic_for_lyme_disease/prweb18247374.htm (Source: PRWeb: Medical Pharmaceuticals)
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Thursday 29 September 2022
(Virginia Tech) Virginia Tech biochemist Brandon Jutras has discovered the cellular component that contributes to Lyme arthritis, a debilitating and extremely painful condition that is the most common late stage symptom of Lyme disease. (Source: EurekAlert! - Infectious and Emerging Diseases)
Thursday 29 September 2022
The Infectious Diseases Society of America (IDSA) could have chosen to settle the lawsuit instead of fighting it, but the principles at stake were too high, they decided.Medscape Medical News (Source: Medscape Rheumatology Headlines)
Thursday 29 September 2022
Joseph Leone seemed to have a mild cold in the summer of 2013. A month later, he collapsed on the front lawn of his home in Poughkeepsie, New York. He died of Lyme disease that attacked his heart. (Source: the Mail online | Health)
Thursday 29 September 2022
WebMD sat down with New York Times columnist Ross Douthat to find out a little bit more about his journey and what he recommends to anyone with Lyme Disease. (Source: WebMD Health)
Thursday 29 September 2022
With the start of peak tick season, check here to spot some of the latest developments in diagnosis and treatment of Lyme disease. (Source: ConsultantLive)
Thursday 29 September 2022
Researchers found that a neglected antibiotic called hygromycin A selectively kills the bacteria that cause Lyme disease. (Source: NIH Research Matters from the National Institutes of Health (NIH))
Thursday 29 September 2022
People presenting erythema migrans, the characteristic skin rash associated with Lyme disease, can be diagnosed and treated without the need for blood tests, NICE has said in a final quality standard published this week. (Source: NHS Networks)
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Thursday 29 September 2022
Did spending more time indoors during the COVID-19 pandemic result in fewer reported cases of Lyme disease?Emerging Infectious Diseases (Source: Medscape Today Headlines)
Thursday 29 September 2022
After my tick bite I realised that the climate crisis was a more likely culprit than any conspiracy theory about weaponisationThe first indication I ’d picked up a tick-borne disease three years ago was the excruciating arthritic pain in my feet as I hobbled to a dinner party at a neighbour’s house in Jerusalem.Later that night I experienced flu-like symptoms, including a raging fever that, even with antibiotics, would last for more than a week.Continue reading... (Source: Guardian Unlimited Science)
Thursday 29 September 2022
A Yale-developed vaccine that helps more quickly identify tick bites on guinea pigs could offer humans protection against Lyme Disease and other pathogens. (Source: Yale Science and Health News)
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Thursday 29 September 2022
(University of California - Irvine) As Lyme disease increases, researchers have taken a significant step toward finding new ways to prevent its transmission. The experts, who include a pioneer in Lyme disease discovery, have sequenced the genome of the animal carrying the bacteria that causes the illness. The advance by researchers at the University of California, Irvine and colleagues provides a launching pad for fresh approaches to stopping Lyme disease from infecting people. (Source: EurekAlert! - Infectious and Emerging Diseases)
Thursday 29 September 2022
NIH researcher Andaleeb Sajid discusses her study ’s finding that ticks were unable to feed on vaccinated guinea pigs, preventing transmission of the pathogen that causes Lyme disease. (Source: The Scientist)
Thursday 29 September 2022
LYME DISEASE is known as a form of arthritis caused by bacteria that is transmitted by ticks. If detected early it can often be treated effectively. What are the three signs you may have Lyme disease? (Source: Daily Express - Health)
Thursday 29 September 2022
Kate Allen, 28, from Leicester, spotted raised bumps on her skin after walking her dog through long grass in the park in 30°C. Lyme disease is spread by tick bites. (Source: the Mail online | Health)
Thursday 29 September 2022
Steven Williams, 36, said his fit, active life was "totally devastated" by the struggle for answers. (Source: BBC News | Health | UK Edition)
Thursday 29 September 2022
Lexington sepsis and lyme disease diagnostics maker T2 Biosystems will need a new CEO to lead it through its ongoing financial struggles. T2 Biosystems (Nasdaq: TTOO) reported after markets closed Tuesday that CEO John McDonough will be stepping down from his role to become executive chairman of the company's board of directors. He will stay in the CEO role until the company hires his successor, according to a press release. McDon ough has been in the top job at T2 since 2007, leading T2 Biosystems… (Source: bizjournals.com Health Care:Biotechnology headlines)
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Thursday 29 September 2022
Steven Williams was left bedridden and shaking for 18 hours a day after contracting the illness. (Source: BBC News | Health | UK Edition)
Thursday 29 September 2022
LYME DISEASE is on the rise according to Doctor Hilary on Lorraine with new cases of the disease everyday. What is it and how to know if you might have it? (Source: Daily Express - Health)
Thursday 29 September 2022
In March 2020, Laura Fitton, a 50-year-old entrepreneur in Massachusetts, had a high fever, sore throat, gastrointestinal issues, and loss of taste. But at the time, few of those symptoms were linked to COVID-19, so Fitton wasn’t eligible for a test. It took seven more months of persistent symptoms—including brain fog, swollen joints, fast heart rate, chills, and fatigue—for a doctor to order an antibody test. Although the test came back negative—perhaps because of how much time had passed since she had gotten sick—Fitton was relieved that a doctor was finally exploring the possibility of Long COVID, a little-understood condition in which people suffer symptoms long after their acute infection passes. [time-brightcove not-tgx=”true”] Two years afte...
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Thursday 29 September 2022
We know far too little about Lyme and how to diagnose it, let alone have agreement between major advisory groups as to how to treat the disease. (Source: Forbes.com Healthcare News)
Thursday 29 September 2022
Valneva SE (Nasdaq: VALN; Euronext Paris: VLA), a specialty vaccine company, and Pfizer Inc. (NYSE: PFE) today reported further positive Phase 2 data for their Lyme disease vaccine candidate, VLA15. Based on these new results, Valneva and Pfizer plan to proceed with a three-dose primary series vaccination schedule in a planned Phase 3 clinical trial. (Source: World Pharma News)
Thursday 29 September 2022
Some tick-spread bacteria could be weaponized — but this would be a pretty useless choice. (Source: Washington Post: To Your Health)
Thursday 29 September 2022
Newcastle-under-Lyme MP Aaron Bell says a "breach of trust" has made the PM's position "untenable". #tory #newcastleunderlyme #confidenceletter #aaronbell (Source: Reuters: Health)
Thursday 29 September 2022
White older women in south-west England appear most likely to contract the disease, a study suggests. (Source: BBC News | Health | UK Edition)
Thursday 29 September 2022
The complex interplay of ticks, their habitats and hosts — along with changes in land use and climate — may be enabling the spread of the pathogens they carry.Knowable Magazine (Source: Medscape Infectious Diseases Headlines)
Thursday 29 September 2022
Public comments are still being accepted, but antibiotic treatment options for children are likely to be expanded to include the use of doxycycline. (Source: NYT Health)
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Thursday 29 September 2022
US researchers, who identified the gene editing method, said it could enable them to alter parts of a tick's DNA used to carry and transmit bacteria that causes diseases. (Source: the Mail online | Health)
Thursday 29 September 2022
Analysis (n=2361) noted significant increase (p (Source: Current Awareness Service for Health (CASH))
Thursday 29 September 2022
DR ELLIE CANNON: It is true Lyme disease can cause neurological problems, including dizziness and feeling off-balance, but it's rare for such symptoms to be the only complaint. (Source: the Mail online | Health)
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Thursday 29 September 2022
The first human Lyme vaccine was pulled off the market nearly 20 years ago. A new effort faces lingering suspicions.Undark (Source: Medscape Allergy Headlines)
Thursday 29 September 2022
Ticks have evaded gene editing attempts for years, but scientists have finally figured out how to effectively modify their genome as they work to reduce disease transmission. (Source: WebMD Health)
Thursday 29 September 2022
Discussion Lyme disease (LD) is caused by several genospecies of Borrelia burgdorferi senu lato that are transmitted by ticks of the Ixodes ricinus complex. In the U.S. and Europe it is the most common vector-borne disease. It is named for Lyme, Connecticut in the 1970s when it was “discovered,” but there are reports of LD-type disease in Europe since 1883. There are 18 distinct genospecies with B. afzelii, B. garinii and B. burgdorferi sensu stricto being the 3 most common ones causing human infection. There are many species of Ixodes ticks but only 4 commonly bite humans. Ixodes ricinus mainly in Europe, I, persultcatus in Asia, I. scapularis in the eastern and central US, and I. pacificus in the western US and Canada. However I. pacificus is rarely infected and accounts for ...
Thursday 29 September 2022
Ticks have evaded gene editing attempts for years, but scientists have finally figured out how to effectively modify their genome as they work to reduce disease transmission.WebMD Health News (Source: Medscape Infectious Diseases Headlines)
Thursday 29 September 2022
Waiting for test results before initiating therapy for patients suspected of having Lyme carditis may result in death, data from two recent cases show.Medscape Medical News (Source: Medscape Internal Medicine Headlines)
Thursday 29 September 2022
Two years into the COVID-19 pandemic, questions about Long COVID still outnumber answers. Why do some people develop long-lasting symptoms—often after a mild case of COVID-19, sometimes even after being vaccinated—while others fully recover from their brushes with the SARS-CoV-2 virus? Why does Long COVID seem to disproportionately appear in women? How can one condition affect numerous bodily systems, causing symptoms ranging from brain fog to joint pain to total exhaustion? Is Long COVID a single diagnosis, or is it better understood as an umbrella term for a spectrum of disease, caused by a range of biologically diverse effects of the virus? Or, could it actually be a new manifestation of post-viral illnesses that have been around for decades? [time-brightcove not-tgx=”...
Thursday 29 September 2022
LYME disease is an infectious disease caused by a bacterium named Borrelia, spread by ticks found in the woods. It can easily be caught and if a person experiences this one particular sign it could be a major warning that you may be at risk of having the disease. What is it? (Source: Daily Express - Health)
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Thursday 29 September 2022
The number of ticks sent to the Upstate lab as part of its citizen science program has skyrocketed with more than 30 percent found to be carrying Lyme disease. (Source: SUNY Upstate Medical)
Thursday 29 September 2022
Fundamental misunderstandings exist among both patients and practitioners about the nature of tick-borne infections. This review aims to address these issues from the neurologist's perspective.Seminars in Neurology (Source: Medscape Today Headlines)
Thursday 29 September 2022
The number of ticks sent to the Upstate lab as part of its citizen science program has skyrocketed with more than 30 percent found to be carrying Lyme disease. (Source: SUNY Upstate Medical)
MedWorm Message: Have you tried our new medical search engine? More powerful than before. 100% free.
Thursday 29 September 2022
(FAIR Health) From 2007 to 2018, claim lines with diagnoses of Lyme disease increased nationally 117%. The new FAIR Health Study Uncovers Geographic, Age and Gender Variation, among Other Notable Statistics. Comparing Lyme disease to other tick-borne diseases, the study draws on data from FAIR Health's comprehensive repository of over 29 billion private healthcare claim records -- the largest in the country. (Source: EurekAlert! - Infectious and Emerging Diseases)
Thursday 29 September 2022
ACTOR Ben Stiller, who starred in classics like Night at the Museum and Meet the Fockers was diagnosed with Lyme disease. The star underwent lots of tests before he finally discovered the reality of his situation. (Source: Daily Express - Health)
Thursday 29 September 2022
Thursday 29 September 2022
ALEC BALDWIN, 64, said his family "live in fear" of Lyme disease after the star was "attacked" by the condition for two decades. (Source: Daily Express - Health)
Thursday 29 September 2022
Here are some of the latest health and medical news developments, compiled by the editors of HealthDay: Justin Bieber Reveals He Has Lyme Disease Singer Justin Bieber says he has Lyme disease. He revealed his condition Wednesday in an Instagram... (Source: Drugs.com - Daily MedNews)
Thursday 29 September 2022
A test that detects antiphospholipid antibodies in the blood of Lyme disease patients shows potential for identifying the disease sooner than current methods and possibly tracking response to therapy and recurrence, researchers say.Reuters Health Information (Source: Medscape Pathology Headlines)
Thursday 29 September 2022
Here is why Lyme Disease is tough to diagnose, tough to understand, and tough to have. (Source: Forbes.com Healthcare News)
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Thursday 29 September 2022
Title: What Is Chronic Lyme Disease (Stage 3)?Category: Diseases and ConditionsCreated: 6/17/2020 12:00:00 AMLast Editorial Review: 4/8/2022 12:00:00 AM (Source: MedicineNet Arthritis General)
Thursday 29 September 2022
AUGUSTA, Maine (AP) — Maine reported a record number of Lyme disease cases last year, and the number could rise as data continues to trickle in, officials said Thursday. There were at least 2,079 cases in 2019, the Maine Center for Disease Control and Prevention reported. It’s too early to say why the numbers grew last year. But the numbers underscore the importance of taking precautions to avoid tick bites, said Dr. Nirav Shah, director of the Maine CDC. Winter is a time of low ticket activity. But ticks can be active when the temperature climbs above 40, as it did last weekend in Maine. The state also experienced increases in two other tickborne diseases, with 685 cases of anaplasmosis and 138 cases of babesiosis. Lyme disease is caused by bacteria carried by infected deer ticks....
Thursday 29 September 2022
Common measures to kill the harmful pests appear to protect pets more than people, researchers say. (Source: WebMD Health)
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Thursday 29 September 2022
ORONO, Maine (AP) — More than a third of the deer ticks submitted to a Maine lab last year tested positive for Lyme disease, a surveillance report from the lab said. The report is from the University of Maine Tick Lab. The lab found that a smaller percentage of ticks tested positive for anaplasmosis and babesiosis, which are other tick-borne diseases. The tick lab’s manager, Griffin Dill, said the information will help authorities learn how fast the ticks are spreading in the state. The study is the first of its kind in Maine, the Bangor Daily news reported. The report found that just shy of 39% of deer ticks tested positive for Lyme. The data also show ticks were more frequently found higher on the bodies of children than adults. Lyme disease can cause symptoms such as neck stiffn...
Thursday 29 September 2022
Discussion Vocal cord function involves balancing muscular and neuronal functions. The superior laryngeal nerves (SLN) and recurrent laryngeal nerves (RLN) are the main nerves responsible for sensation and motor innervation. There are two sides to the larynx and they operate ipsilaterally, therefore one side can be affected while the other is not. Vocal cord paresis or paralysis are “an impairment of the vocal fold motor function that is caused by nerve or neuromuscular abnormalit[ies].” Paresis involves some maintenance of vocal cord movement while paralysis does not. Paresis is also more of a continuum than an absolute movement or not. “Paresis is often considered idiopathic, but potentially any pathology present from skull base to mediastinum that compresses, tethers, ...
Thursday 29 September 2022
LYME disease is a bacterial infection that is passed on to humans by infected ticks. High-risk areas include grassy and wooded areas, making that leisurely stroll not seem so idyllic any more. Look for a sign on your knee that you may be needing a visit to your doctors pronto. (Source: Daily Express - Health)
Thursday 29 September 2022
When Virginia Sen. Tim Kaine came down with a “blizzard” of allergy-like symptoms in March 2020, he blamed the layer of pollen coating his car. “It was Washington, D.C., in late March,” he says. I thought, “‘Okay, well, this is hay fever gone wild.’” Only when his wife, Anne Holton, developed “textbook” COVID-19 symptoms did Kaine start to wonder if he might have the new virus, the subject of the massive economic assistance bill—the CARES Act—that he and other lawmakers were then working to pass. Testing at that time was hard to come by, even for Hillary Clinton’s 2016 running mate, but antibody tests later revealed that Kaine and Holton had been infected by the virus that causes COVID-19. [time-brightcove not-t...
Thursday 29 September 2022
Supporting entrepreneurs can take many forms from grants to providing access to capital and from expanding their networks of mentors and peers to providing training that addresses both hard and soft skills. (Source: Forbes.com Healthcare News)
Thursday 29 September 2022
GPs are failing to spot the early signs of Lyme disease, an infection spread through tick bites that is on the rise in the UK, experts warn. Early diagnosis allows treatment with anti-biotics. (Source: the Mail online | Health)
Thursday 29 September 2022
Prepare for tick season by reviewing these five things to know about Lyme disease testing.CDC Expert Commentary (Source: Medscape Infectious Diseases Headlines)
Thursday 29 September 2022
Patients with localized disease had the lowest attributed costs, highlighting the importance of early diagnosis and intervention.Medscape Medical News (Source: Medscape Medical News Headlines)
Thursday 29 September 2022
(Washington State University) The next time a tick feeds on you, Washington State University researchers hope to make sure persistent arthritis caused by Lyme disease doesn't linger for a lifetime. (Source: EurekAlert! - Medicine and Health)
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Thursday 29 September 2022
The lone star tick can trigger an allergic reaction to red meat in those bitten. Now this arachnid ’s territory is expanding. (Source: NYT Health)
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Thursday 29 September 2022
(Canadian Medical Association Journal) Physicians and the public should be aware of the different presentations of Lyme disease, as people spend more time outside in the warmer weather and as areas in Canada where the black legged tick is found expand. Three articles in CMAJ (Canadian Medical Association Journal), which describe a fatal case in a 37-year-old man, atypical skin lesions in a 56-year-old woman and severe neurological symptoms in a 4-year-old boy, illustrate the diversity in presentations. (Source: EurekAlert! - Medicine and Health)
Thursday 29 September 2022
LYME disease is a type of bacterial infection spread to humans from infected ticks. While not much of a problem during the winter, Lyme disease can be a danger during the summer. As a result, it's important to be wary of the symptoms to look out for. (Source: Daily Express - Health)
Thursday 29 September 2022
With America on lockdown the past two months, many people turned to the woods for safe isolation and social distancing. And now as sections of the country reopen and summer approaches, the outdoors...(PRWeb June 02, 2020)Read the full story at https://www.prweb.com/releases/knowing_signs_and_symptoms_of_lyme_disease_is_critical_for_early_detection_and_treatment_says_industry_leading_quidel/prweb17162063.htm (Source: PRWeb: Medical Pharmaceuticals)
Thursday 29 September 2022
Americans can avoid contracting Lyme disease, if they take a few simple steps. The steps include regular tick checks, wearing long sleeves in areas of high exposure and using bug spray. (Source: the Mail online | Health)
Thursday 29 September 2022
Kate Winslet picture about renowned fossil hunter had been criticised by relatives for ‘unconfirmed’ portrait of her sexualityThe director of a new biopic about the celebrated fossil hunter Mary Anning has defended his film after criticism of its lesbian romance storyline.Ammonite, which stars Kate Winslet and Saoirse Ronan, recently began filming in Lyme Regis, the coastal town in Dorset where Anning lived in the early 19th century. Anning never married and is not known to have had any direct descendants, but a report in the Telegraph suggested her distant relatives were at odds over the film ’s central relationship, a romance between Anning and Frances Bell, with whom Anning is known to have corresponded.Continue reading... (Source: Guardian Unlimited Science)
Thursday 29 September 2022
A nine-year-old pointed out what was missing in Lyme Regis. Her long campaign has now borne fruitIt all began with a curious nine-year-old and a question that she asked her mother. Where in their hometown of Lyme Regis was the statue ofMary Anning, the pioneering Victorian fossil hunter who, she had recently discovered, had lived and worked there?There wasn ’t one, Anya Pearson was forced to tell her indignant daughter. Anning’s lifetime of discoveries – including finding the first ichthyosaur skeleton at the age of just 12 – may have profoundly shaped the emerging science of palaeontology, but in her own Dorset town and farther afield, she had been largely forgotten.Continue reading... (Source: Guardian Unlimited Science)
Thursday 29 September 2022
LYME disease is still a relatively unknown disease with a myriad of symptoms which makes it difficult to detect. One such unusual symptom is that of losing your voice which left untreated could lead to vocal chord paralysis. (Source: Daily Express - Health)
Thursday 29 September 2022
Russell Bell, 65, from Raleigh in North Carolina, was only diagnosed with the tick-borne disease after he went for tests nine months after developing symptoms. He died earlier this year. (Source: the Mail online | Health)
Thursday 29 September 2022
With climate change, we are seeing more tick-borne diseases. Where is the funding to address this urgent crisis? (Source: Forbes.com Healthcare News)
Thursday 29 September 2022
Russell Bell, 65, from Raleigh in North Carolina, was only diagnosed with the tick-borne disease after he went for tests nine months after developing symptoms. He died earlier this year. (Source: the Mail online | Health)
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Thursday 29 September 2022
It got its start in developing a urine test for human growth hormones. But it hopes to go well beyond that now. (Source: bizjournals.com Health Care:Physician Practices headlines)
Thursday 29 September 2022
TUESDAY, June 7, 2022 -- American farmers are at increased risk for tick bites, but new research shows they are doing little to defend themselves against the insects and the illnesses they cause. Tick-borne diseases include Lyme disease, Rocky... (Source: Drugs.com - Daily MedNews)
Thursday 29 September 2022
BOSTON (CBS) – After more than a decade, experts are issuing new guidelines for the prevention and treatment of Lyme disease. Even though many of the recommendations are geared toward medical professionals, there are some key takeaways for the general public. Namely, the best way to protect yourself is to wear protective clothing and insect repellent with DEET and do frequent tick checks if you’ve been outdoors. Bathing within two hours of an outdoor activity can reduce the risk of Lyme disease. And if you have pets, you should check them regularly for ticks to prevent the ticks from falling off and reattaching to humans. If you are bitten by a deer tick, it’s engorged, and it has been attached for 36 hours or more, you should call your doctor or get to an urgent care fac...
Thursday 29 September 2022
Last year, Diana Berrent—the founder of Survivor Corps, a Long COVID support group—asked the group’s members if they’d ever had thoughts of suicide since developing Long COVID. About 18% of people who responded said they had, a number much higher than the 4% of the general U.S. adult population that has experienced recent suicidal thoughts. A few weeks ago, Berrent posed the same question to current members of her group. This time, of the nearly 200 people who responded, 45% said they’d contemplated suicide. While her poll was small and informal, the results point to a serious problem. “People are suffering in a way that I don’t think the general public understands,” Berrent says. “Not only are people mourning the life that they thought...
Thursday 29 September 2022
Politicians in the US have ordered the military to reveal details of a programme believed to have tried to 'weaponise' ticks, which may have led to them escaping and spreading Lyme disease. (Source: the Mail online | Health)
Thursday 29 September 2022
Researchers from China, who examined blood sample data from studies involving more than 150,000 people, found 14.5 per cent had Lyme disease. (Source: the Mail online | Health)
Thursday 29 September 2022
(CNN) — Health officials in Maine are warning about the potential for more cases of Powassan virus disease after one person was confirmed to be sick with the rare tick-borne illness, the first reported case in the state since 2017. The Maine Center for Disease Control and Prevention said Wednesday that a person in the southern part of the state had Powassan encephalitis, a severe disease that causes inflammation in the brain. The agency said the patient showed symptoms in late June and was hospitalized. The Maine CDC issued an advisory to physicians that more cases could be possible and suggested that doctors consider testing for the disease in patients with unexplained encephalitis, meningitis or high fever during the summer and early fall. Powassan virus disease is spread by three ...
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Thursday 29 September 2022
Lyme disease has infected more than 14% of the world's population, according to a new study. "It's significant," says Dr. Bobbi Pritt, director of the Clinical Parasitology Laboratory at Mayo Clinic. "If you look at the numbers and how it breaks down in regions across the United States, in some areas, that exceeds 50% seropositivity. That means people are walking around with antibodies in their blood that are detectable. That shows they've been exposed to Lyme disease at some… (Source: News from Mayo Clinic)
Thursday 29 September 2022
New cases of tick-borne Lyme disease might top 8000 in 2019, researchers estimate Related items fromOnMedica Well over half of people have never had an STI test HPV programme linked to dramatic fall in cervical disease Should we have compulsory measles vaccination at school entry? Promise to end new HIV transmissions in England by 2030 Decision to give boys HPV jab will save thousands of lives (Source: OnMedica Latest News)
Thursday 29 September 2022
TUESDAY, June 14, 2022 -- The reported estimated global seroprevalence of Borrelia burgdorferi sensu lato (Bb) is 14.5 percent, according to a systematic review and meta-analysis published online June 13 in BMJ Global Health. Yan Dong, from the... (Source: Drugs.com - Pharma News)
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Thursday 29 September 2022
As tick populations take hold permanently in large swaths of Canada, more people will be exposed and contract Lyme disease. (Source: CBC | Health)
Thursday 29 September 2022
Lyme disease was first named nearly 50 years ago in Lyme, Connecticut, but the tick-borne disease is now found around the world. A new study published in BMJ Global Health estimates that 14.5% of the world’s population has, at some point, been infected with Lyme disease, which can cause short-term symptoms including a skin rash, fever, headache, and fatigue—as well as long-term ones, including damage to the joints, heart, and nervous system. The scourge also appears to be getting worse. Lyme prevalence has doubled from 2010 to 2021, compared to 2001 to 2010. [time-brightcove not-tgx=”true”] The study, led by a team of researchers from the Institute for Tropical Medicine at Kunming Medical University in China, was a meta-analysis of 89 studies dating as far back as ...
Thursday 29 September 2022
LYME disease is a bacterial infection spread to humans by infected ticks. The condition can be treated effectively if detected early, but a delay in recognising it can increase the risk of developing long-lasting symptoms. (Source: Daily Express - Health)
Thursday 29 September 2022
Lyme prevalence is increasing. Are we paying attention?Medscape (Source: Medscape Today Headlines)
Thursday 29 September 2022
Finding an effective way to prevent the spread of tick-borne illness such as Lyme disease has been quite challenging over the past several decades. Researchers have now developed a new approach that goes right to the place where a tick transmits disease: its salivary glands. (Source: Forbes.com Healthcare News)
Thursday 29 September 2022
Scientists in southern China estimated as many as 32million Americans may have had the disease at some point in their lives. Globally, up to 14 percent of people are thought to have been infected. (Source: the Mail online | Health)
Thursday 29 September 2022
Most people who think they have chronic Lyme disease are more likely to have chronic fatigue syndrome, say experts. (Source: BBC News | Health | UK Edition)
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Thursday 29 September 2022
DEAR MAYO CLINIC: A close friend was diagnosed recently with Lyme disease due to a tick bite. However, I recently read about some new type of tick-borne illness. My family loves to hike and be outdoors, but I'm nervous now about continuing our activities. How can I reduce our risk of illness from insect bites and protect my family? ANSWER: Enjoying the outdoors is a wonderful way to spend quality family time together, but there are certainly… (Source: News from Mayo Clinic)
Thursday 29 September 2022
As vectors for Lyme disease, black-legged ticks present a public health crisis in North America. Are current prevention recommendations appropriate? Where should prevention efforts be focused?American Journal of Epidemiology (Source: Medscape Today Headlines)
Thursday 29 September 2022
US pharma group to pay €90.5mn for 8% in deal that will boost joint Lyme disease programme (Source: FT.com - Drugs and Healthcare)
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Thursday 29 September 2022
Scientists at Columbia University, New York, are developing test that uses microchips to detect antibodies against Lyme disease. The condition, spread by ticks, can be fatal to humans. (Source: the Mail online | Health)
Thursday 29 September 2022
An economic evaluation of the costs associated with Lyme disease underscores the importance of effective prevention measures.Emerging Infectious Diseases (Source: Medscape Today Headlines)
Thursday 29 September 2022
In Lyme disease-endemic areas, a C6 peptide enzyme immunoassay (EIA) test may help guide initial management of children with acute arthritis, an observational study suggests.Reuters Health Information (Source: Medscape Orthopaedics Headlines)
Thursday 29 September 2022
Scientists are studying why tick-borne infections, including Lyme disease, are on the rise and why ticks are expanding into new geographic areas. Lyme disease, the most common tick-borne infection, is caused by the bacteria Borrelia burgdorferi and Borrelia mayonii. It's transmitted by the bite of an infected blacklegged tick, previously known as a deer tick. The Northeast and Upper Midwest are hot spots for Lyme disease, though there are other parts of the U.S. and the world… (Source: News from Mayo Clinic)
Thursday 29 September 2022
A engineer forced to quit work hopes pop star Justin Bieber will raise awareness of the condition. (Source: BBC News | Health | UK Edition)
Thursday 29 September 2022
The trends show that tick-borne illnesses are becoming a more common concern nationally, not just in the areas where Lyme disease has been found historically.WebMD Health News (Source: Medscape Infectious Diseases Headlines)
Thursday 29 September 2022
LYME disease is a bacterial infection which could lead to severe physical and mental problems if not diagnosed at an early stage. Spotting the early warning signs will ensure prompt treatment and noticing this peculiar feeling in the head could mean you're at risk. (Source: Daily Express - Health)
Thursday 29 September 2022
Insurance Data Shows Big Rise in Lyme Disease in US (Source: eMedicineHealth.com)
Thursday 29 September 2022
SUNDAY, March 22, 2020 -- Where you put leaves raked from your yard last fall could affect your family's risk of bites from ticks that transmit Lyme disease-causing bacteria, a new study suggests. In areas where Lyme-causing ticks are prevalent,... (Source: Drugs.com - Daily MedNews)
Thursday 29 September 2022
US drugmaker and French partner begin late-stage trial with 14% of global population showing evidence of infection (Source: FT.com - Drugs and Healthcare)
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Thursday 29 September 2022
Researchers are seeking thousands of volunteers in the U.S. and Europe. (Source: ABC News: Health)
Thursday 29 September 2022
(DOE/Oak Ridge National Laboratory) A team of researchers from the Department of Energy's Oak Ridge National Laboratory (ORNL) Health Data Sciences Institute (HDSI) have harnessed the power of artificial intelligence (AI) to better match cancer patients with clinical trials. The researchers were one of ten teams to develop a digital tool to address complex challenges relevant to medical conditions such as cancer and Lyme disease as part of The Opportunity Project (TOP) Health Sprint. (Source: EurekAlert! - Cancer)
Thursday 29 September 2022
Pfizer and French biotech company Valneva are seeking volunteers to test their new vaccine against Lyme disease, which could protect both adults and kids as young as five from the tick-borne illness. (Source: CBC | Health)
Thursday 29 September 2022
Lyme disease and rheumatoid arthritis are both conditions that can affect the nervous system and cause joint pain and swelling. Learn about their similarities and differences here. (Source: Health News from Medical News Today)
Thursday 29 September 2022
PET scans have demonstrated for the first time that only women appear to experienc...Read more on AuntMinnie.comRelated Reading: PET brain scans find links to PTSD severity in 9/11 responders PET tracers reveal long-term consequences of brain injuries Preclinical PET study offers better Alzheimer's detection Carbon-11 PET detects brain inflammation after Lyme disease C-11-based PET tracer could benefit arthritis patients (Source: AuntMinnie.com Headlines)
Thursday 29 September 2022
Katherine Wood, 37, of Stow, Massachusetts, was bitten on a tick while on a nature walk in November 2016. Doctors dismissed her symptoms, until she was diagnosed with Lyme disease in July 2017. (Source: the Mail online | Health)
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Thursday 29 September 2022
If successful, the vaccine would be the first against Lyme disease in the United States since Lymerix, which was discontinued in 2002 because of poor sales. (Source: Washington Post: To Your Health)
Thursday 29 September 2022
The tick-borne illness, which is on the rise, can have chronic side-effects. So why hasn ’t more effort been put into a cure?As a former martial arts world champion, who trained daily and enjoyed camping and hiking at weekends, Stephen Bullough had always prided himself on leading a healthy life.Like most people, he thought very little when he was bitten by a tick on a camping holiday close to home in Wigan in 2014, never suspecting that this tiny bite would unleash an infection in his body that would one day leave him permanently incapacitated.Continue reading... (Source: Guardian Unlimited Science)
Thursday 29 September 2022
(MedPage Today) -- Note that some links may require registration or subscription. A group of 23 state attorneys general led by Florida told a federal court Monday that the CDC does not have the legal authority to impose a nationwide transportation... (Source: MedPage Today Public Health)
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Thursday 29 September 2022
LYME DISEASE is currently on the rise, as scientists have found there could be far more cases of the disease than previously estimated. What are the symptoms of Lyme disease? (Source: Daily Express - Health)
Thursday 29 September 2022
A new Lyme disease could be available in the U.S. as early as 2025, as Pfizer has launched final clinical trials for its jab, VLA15. The company is aiming to apply for FDA approval in 2025. (Source: the Mail online | Health)
Thursday 29 September 2022
Disease most common in women aged 61 to 65 Related items fromOnMedica Not tackling infections in homeless could spark epidemics Concerns over UK young adults ’ readiness for first sex Malaria cases rise sharply Texting can improve flu jab uptake HPV programme linked to dramatic fall in cervical disease (Source: OnMedica Latest News)
Thursday 29 September 2022
If the trial succeeds, the vaccine could be the first human vaccine for the tick-borne illness in the US in two decades.WebMD Health News (Source: Medscape PublicHealth Headlines)
Thursday 29 September 2022
Rapid assay for Lyme disease could lead to a practical test for use by healthcare providers. (Source: National Institutes of Health (NIH) News Releases)
Thursday 29 September 2022
Vaccine maker Pfizer says it has begun Phase 3 clinical trial of its vaccine candidate against Lyme disease with French vaccine company Valneva SE. (Source: CNN.com - Health)
Thursday 29 September 2022
Insurance claim lines related to Lyme disease, a bacterial infection transmitted through the bite of black-legged ticks, increased by 117 percent across the country between 2007 and 2018, according to new research. (Source: Health News - UPI.com)
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Thursday 29 September 2022
As global temperatures have risen in recent decades, so have the number of outbreaks of infectious diseases. SARS, MERS, Zika, West Nile, COVID-19, and now clusters of monkeypox and polio have all recently threatened public health. That’s no coincidence. In a study published in August in Nature Climate Change, researchers tried to understand the relationship between major environmental changes related to higher greenhouse gas emissions—including global warming, rising sea levels, storms, floods, drought, and heat waves—and the outbreaks of 375 human infectious diseases caused by viruses, bacteria, and other pathogens. They found that 58% of these public-health threats were fueled by climate change. [time-brightcove not-tgx=”true”] “The health impacts of ...
Thursday 29 September 2022
Engineers with the University of Cincinnati have created a tiny portable lab that plugs into your phone, connecting it automatically to a doctor's office through a custom app UC developed. The lab the size of a credit card can diagnose infectious diseases such as coronavirus, malaria, HIV or Lyme disease or countless other health conditions like depression and anxiety. (Source: World Pharma News)
Thursday 29 September 2022
A vaccine designed to protect against Lyme disease is being trialled and, if successful, could be available for use in 2025. Lyme disease is an infection spread by ticks. (Source: the Mail online | Health)
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Thursday 29 September 2022
With Lyme disease on the rise, people need to take special care to avoid tick encounters amid the COVID-19 crisis. (Source: Science - The Huffington Post)
Thursday 29 September 2022
Experts warn high seasonal temperatures are opening up new habitats for northern ticks in mountainous areas of southern states. But increasesd awareness may also fuel the rise. (Source: the Mail online | Health)
Thursday 29 September 2022
LYME DISEASE is a bacterial infection that affects up to 3,000 people in the UK every year. ITV This Morning ’s Dr Ranj has revealed the lyme disease signs and symptoms to watch out for, including a characteristic rash. Watch out for these symptoms are a tick bite. (Source: Daily Express - Health)
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Thursday 29 September 2022
This review provides an approach to patients with neurological disorders in whom a diagnosis of Lyme neuroborreliosis is being considered. What does and does not constitute nervous system disease?Brain (Source: Medscape Today Headlines)
Thursday 29 September 2022
LYME DISEASE is an infectious disease caused by a bacterium named Borrelia, spread by ticks. It can easily be caught and having a feeling in your head could mean you have the disease. (Source: Daily Express - Health)
Thursday 29 September 2022
A new study suggests the overpopulation of white-tailed deer across the Northeastern U.S. could help spread Lyme disease, especially in suburban areas. (Source: WebMD Health)
Thursday 29 September 2022
The biggest problem is that there is no way to test, unequivocally, for the presence of the bacteria that cause the disease. (Source: NYT Health)
Thursday 29 September 2022
Meghan Bradshaw, now 29 and from Charlotte in North Carolina, was described by doctors as the 'worst case' of Lyme disease they had seen. She now says she is a 'bionic woman'. (Source: the Mail online | Health)
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Thursday 29 September 2022
Is whole blood-RT-PCR useful as a diagnostic aid for early Lyme disease when done in conjunction with serology testing?American Journal of Clinical Pathology (Source: Medscape Today Headlines)
Thursday 29 September 2022
According to a recent study, more than 14% of the world ’s population probably has, or has had, tick-borne Lyme disease – an infection that can cause long and debilitating symptoms. That number is set to rise too, as climate and environment changes continue to increase tick populations and distribution.To help prevent some of these cases, pharmaceutical company Pfizer and biotech company Valneva will soon be testing a new vaccine against Lyme disease with 6,000 volunteers across Europe and in the US.Madeleine Finlay speaks to Dr Eoin Healy about what Lyme disease is and how the vaccine works, and hears from a special guest about their own experience of getting ill with the disease.Archive: BBC News, TODAYContinue reading... (Source: Guardian Unlimited Science)
Thursday 29 September 2022
TUESDAY, Sept. 20, 2022 -- They look so cute, grazing quietly in your backyard. But the overpopulation of white-tailed deer across the Northeastern United States could help spread Lyme disease and another tick-borne illness, anaplasmosis, especially... (Source: Drugs.com - Daily MedNews)
Thursday 29 September 2022
BOSTON (CBS) — Looking back at baby pictures reminds Brandi Dean of a terrifying scare during her second pregnancy. It turns out the Wellesley mom had Lyme disease. “All of a sudden, the right side of my body was completely numb. My heart was racing. I was disoriented and I said, ‘I think you need to take me to the hospital,’” she remembered. After the standard antibiotic treatment, Dean still didn’t feel right. “I’d gone to 12 different specialists and they all had diagnosed me with anxiety.” She had what the Centers for Disease Control calls Post-Treatment Lyme Syndrome. She eventually found a doctor who understood her condition and recovered. Brandi Dean (WBZ-TV) Doctors don’t always know what causes the lingering symptoms, making the diagnosis controversial ...
Thursday 29 September 2022
(MedPage Today) -- Netflix's new documentary, Shania Twain: Not Just a Girl, follows the country singer from Nashville newcomer to international icon. Twain is the best-selling female country artist of all time, with three diamond-certified albums... (Source: MedPage Today Infectious Disease)
Thursday 29 September 2022
Mainstream medicine has failed many Lyme disease patients. It's fast becoming irrelevant. (Source: Forbes.com Healthcare News)
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Thursday 29 September 2022
In 2019, the tick testing program, headed by Upstate Professor Saravanan Thangamani, PhD, received 1,921 tick samples from July through late October. About 25 percent of the ticks were found to carry Lyme disease. (Source: SUNY Upstate Medical)
Thursday 29 September 2022
Fewer than 40% of those bitten by a tick transmitting Lyme disease will have a bullseye rash, and ticks are incredibly small (about the size of a sesame seed), so are easily missed. (Source: Forbes.com Healthcare News)
Thursday 29 September 2022
More details about his affliction will be unveiled in an upcoming documentary series, Bieber said. (Source: Washington Post: To Your Health)
Thursday 29 September 2022
The newly identified protein acts like an early warning signal to the immune system when exposed to the bacteria at causes Lyme disease. (Source: Yale Science and Health News)
Thursday 29 September 2022
Dr Paul Auwaerter comments on the newly approved, modified two-tier approach for diagnosing Lyme disease.Medscape Infectious Diseases (Source: Medscape Infectious Diseases Headlines)
Thursday 29 September 2022
Listen: Mayo Clinic Radio 8/10/19 On the Mayo Clinic Radio podcast, Dr. Gregory Poland, a Mayo Clinic infectious diseases and vaccine expert, gives an update on infectious disease hot topics, including Lyme disease, the ongoing concern about measles, the hope for a universal flu vaccine and new age guidelines for the HPV vaccine. Also on the podcast, Dr. John Lieske explains how kidney stones form and how [...] (Source: News from Mayo Clinic)
Thursday 29 September 2022
Steph Todd, from Thornbury in Gloucestershire, said people say her seizures make it look like she is 'possessed' and that she desperately wants treatment in the US. (Source: the Mail online | Health)
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The list on this page is powered by Medworm, a search engine based on data collected from the RSS feeds of medical sources like science journals and recent medical news articles.
PubMed for moreNote: this automated list may not catch all relevant publications; also it is limited to the past few years. Therefore you may also want to check PubMed, where you can search in a database for thousands of publications from the past decades (highly recommended).
Some additional resources:• Yahoo news - Lyme disease
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• ScienceDaily - lyme disease research